FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:OS9-YEATS4 (FusionGDB2 ID:61740)

Fusion Gene Summary for OS9-YEATS4

check button Fusion gene summary
Fusion gene informationFusion gene name: OS9-YEATS4
Fusion gene ID: 61740
HgeneTgene
Gene symbol

OS9

YEATS4

Gene ID

10956

8089

Gene nameOS9 endoplasmic reticulum lectinYEATS domain containing 4
SynonymsERLEC2|OS-94930573H17Rik|B230215M10Rik|GAS41|NUBI-1|YAF9
Cytomap

12q13.3-q14.1

12q15

Type of geneprotein-codingprotein-coding
Descriptionprotein OS-9amplified in osteosarcoma 9endoplasmic reticulum lectin 2erlectin 2osteosarcoma amplified 9, endoplasmic reticulum associated proteinosteosarcoma amplified 9, endoplasmic reticulum lectinYEATS domain-containing protein 4NuMA binding protein 1glioma-amplified sequence 41nuBI1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000257966, ENST00000315970, 
ENST00000389142, ENST00000389146, 
ENST00000439210, ENST00000552285, 
ENST00000413095, ENST00000435406, 
ENST00000551035, 		ENST00000247843, 
ENST00000548020, 
Fusion gene scores* DoF score23 X 16 X 8=294410 X 4 X 4=160
# samples 2510
** MAII scorelog2(25/2944*10)=-3.55777767139493
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/160*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OS9 [Title/Abstract] AND YEATS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOS9(58090156)-YEATS4(69764486), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOS9

GO:0006621

protein retention in ER lumen

18417469

HgeneOS9

GO:0034976

response to endoplasmic reticulum stress

19084021

TgeneYEATS4

GO:0043967

histone H4 acetylation

14966270

TgeneYEATS4

GO:0043968

histone H2A acetylation

14966270


check buttonFusion gene breakpoints across OS9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across YEATS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB2G-01AOS9chr12

58090156

+YEATS4chr12

69764486

+


Top

Fusion Gene ORF analysis for OS9-YEATS4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000257966ENST00000247843OS9chr12

58090156

+YEATS4chr12

69764486

+
In-frameENST00000257966ENST00000548020OS9chr12

58090156

+YEATS4chr12

69764486

+
In-frameENST00000315970ENST00000247843OS9chr12

58090156

+YEATS4chr12

69764486

+
In-frameENST00000315970ENST00000548020OS9chr12

58090156

+YEATS4chr12

69764486

+
In-frameENST00000389142ENST00000247843OS9chr12

58090156

+YEATS4chr12

69764486

+
In-frameENST00000389142ENST00000548020OS9chr12

58090156

+YEATS4chr12

69764486

+
In-frameENST00000389146ENST00000247843OS9chr12

58090156

+YEATS4chr12

69764486

+
In-frameENST00000389146ENST00000548020OS9chr12

58090156

+YEATS4chr12

69764486

+
In-frameENST00000439210ENST00000247843OS9chr12

58090156

+YEATS4chr12

69764486

+
In-frameENST00000439210ENST00000548020OS9chr12

58090156

+YEATS4chr12

69764486

+
In-frameENST00000552285ENST00000247843OS9chr12

58090156

+YEATS4chr12

69764486

+
In-frameENST00000552285ENST00000548020OS9chr12

58090156

+YEATS4chr12

69764486

+
intron-3CDSENST00000413095ENST00000247843OS9chr12

58090156

+YEATS4chr12

69764486

+
intron-3CDSENST00000413095ENST00000548020OS9chr12

58090156

+YEATS4chr12

69764486

+
intron-3CDSENST00000435406ENST00000247843OS9chr12

58090156

+YEATS4chr12

69764486

+
intron-3CDSENST00000435406ENST00000548020OS9chr12

58090156

+YEATS4chr12

69764486

+
intron-3CDSENST00000551035ENST00000247843OS9chr12

58090156

+YEATS4chr12

69764486

+
intron-3CDSENST00000551035ENST00000548020OS9chr12

58090156

+YEATS4chr12

69764486

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000552285OS9chr1258090156+ENST00000247843YEATS4chr1269764486+16177862071136309
ENST00000552285OS9chr1258090156+ENST00000548020YEATS4chr1269764486+14527862071136309
ENST00000315970OS9chr1258090156+ENST00000247843YEATS4chr1269764486+145162041970309
ENST00000315970OS9chr1258090156+ENST00000548020YEATS4chr1269764486+128662041970309
ENST00000439210OS9chr1258090156+ENST00000247843YEATS4chr1269764486+125242119771250
ENST00000439210OS9chr1258090156+ENST00000548020YEATS4chr1269764486+108742119771250
ENST00000389146OS9chr1258090156+ENST00000247843YEATS4chr1269764486+142759617946309
ENST00000389146OS9chr1258090156+ENST00000548020YEATS4chr1269764486+126259617946309
ENST00000257966OS9chr1258090156+ENST00000247843YEATS4chr1269764486+142759617946309
ENST00000257966OS9chr1258090156+ENST00000548020YEATS4chr1269764486+126259617946309
ENST00000389142OS9chr1258090156+ENST00000247843YEATS4chr1269764486+142559415944309
ENST00000389142OS9chr1258090156+ENST00000548020YEATS4chr1269764486+126059415944309

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000552285ENST00000247843OS9chr1258090156+YEATS4chr1269764486+0.0006056160.9993944
ENST00000552285ENST00000548020OS9chr1258090156+YEATS4chr1269764486+0.0009602180.9990397
ENST00000315970ENST00000247843OS9chr1258090156+YEATS4chr1269764486+0.0006310470.99936897
ENST00000315970ENST00000548020OS9chr1258090156+YEATS4chr1269764486+0.0010455370.9989544
ENST00000439210ENST00000247843OS9chr1258090156+YEATS4chr1269764486+0.0004090840.99959093
ENST00000439210ENST00000548020OS9chr1258090156+YEATS4chr1269764486+0.0006597480.99934024
ENST00000389146ENST00000247843OS9chr1258090156+YEATS4chr1269764486+0.0006482570.9993517
ENST00000389146ENST00000548020OS9chr1258090156+YEATS4chr1269764486+0.0010726050.9989274
ENST00000257966ENST00000247843OS9chr1258090156+YEATS4chr1269764486+0.0006482570.9993517
ENST00000257966ENST00000548020OS9chr1258090156+YEATS4chr1269764486+0.0010726050.9989274
ENST00000389142ENST00000247843OS9chr1258090156+YEATS4chr1269764486+0.0006335790.99936646
ENST00000389142ENST00000548020OS9chr1258090156+YEATS4chr1269764486+0.0010413010.9989587

Top

Fusion Genomic Features for OS9-YEATS4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
OS9chr1258090156+YEATS4chr1269764485+2.34E-081
OS9chr1258090156+YEATS4chr1269764485+2.34E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for OS9-YEATS4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:58090156/chr12:69764486)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneYEATS4chr12:58090156chr12:69764486ENST0000024784337178_226111228.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOS9chr12:58090156chr12:69764486ENST00000257966+514414_429193614.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneOS9chr12:58090156chr12:69764486ENST00000315970+515414_429193668.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneOS9chr12:58090156chr12:69764486ENST00000389142+514414_429193598.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneOS9chr12:58090156chr12:69764486ENST00000389146+515414_429193653.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneOS9chr12:58090156chr12:69764486ENST00000435406+113414_4290561.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneOS9chr12:58090156chr12:69764486ENST00000439210+413414_429134539.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneOS9chr12:58090156chr12:69764486ENST00000551035+113414_4290581.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneOS9chr12:58090156chr12:69764486ENST00000552285+514414_429193613.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneOS9chr12:58090156chr12:69764486ENST00000257966+514108_230193614.0DomainMRH
HgeneOS9chr12:58090156chr12:69764486ENST00000315970+515108_230193668.0DomainMRH
HgeneOS9chr12:58090156chr12:69764486ENST00000389142+514108_230193598.0DomainMRH
HgeneOS9chr12:58090156chr12:69764486ENST00000389146+515108_230193653.0DomainMRH
HgeneOS9chr12:58090156chr12:69764486ENST00000435406+113108_2300561.0DomainMRH
HgeneOS9chr12:58090156chr12:69764486ENST00000439210+413108_230134539.0DomainMRH
HgeneOS9chr12:58090156chr12:69764486ENST00000551035+113108_2300581.0DomainMRH
HgeneOS9chr12:58090156chr12:69764486ENST00000552285+514108_230193613.0DomainMRH
TgeneYEATS4chr12:58090156chr12:69764486ENST000002478433715_158111228.0DomainYEATS
TgeneYEATS4chr12:58090156chr12:69764486ENST000002478433793_97111228.0RegionDiacetylated histone H3 binding


Top

Fusion Gene Sequence for OS9-YEATS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61740_61740_1_OS9-YEATS4_OS9_chr12_58090156_ENST00000257966_YEATS4_chr12_69764486_ENST00000247843_length(transcript)=1427nt_BP=596nt
AAGAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGACTCCTGTTACCCGCAAGTCTGA
CCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCAGA
GCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTG
AAAGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGACAA
AGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAGAGATCAAAGGTGAAGTCCTCTATC
TCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCT
ATGGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGGTAACCCTGTATCATTTGCTAAAGCTGTTTCAAT
CAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATGATGCAAC
AATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAAT
TAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAA
ATGAAATCAGAAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAA
GGTGGGCTTCACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTT
AGCAATAGGAATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTT
TAAGAAAATTCTATGATATTAAGCACAGTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATCAAAAT
TTCATTATAAAGTATTACTTGTACAAATTTTGTACTTCTTTAGTGGCTAGAATTAGTGAAGAAACTTAATGTGTATATTTAATTTCTTCA

>61740_61740_1_OS9-YEATS4_OS9_chr12_58090156_ENST00000257966_YEATS4_chr12_69764486_ENST00000247843_length(amino acids)=309AA_BP=193
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEET
PAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK
CDLNGRPREAEVRVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKK

--------------------------------------------------------------
>61740_61740_2_OS9-YEATS4_OS9_chr12_58090156_ENST00000257966_YEATS4_chr12_69764486_ENST00000548020_length(transcript)=1262nt_BP=596nt
AAGAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGACTCCTGTTACCCGCAAGTCTGA
CCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCAGA
GCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTG
AAAGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGACAA
AGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAGAGATCAAAGGTGAAGTCCTCTATC
TCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCT
ATGGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGGTAACCCTGTATCATTTGCTAAAGCTGTTTCAAT
CAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATGATGCAAC
AATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAAT
TAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAA
ATGAAATCAGAAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAA
GGTGGGCTTCACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTT
AGCAATAGGAATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTT
TAAGAAAATTCTATGATATTAAGCACAGTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATCAAAAT

>61740_61740_2_OS9-YEATS4_OS9_chr12_58090156_ENST00000257966_YEATS4_chr12_69764486_ENST00000548020_length(amino acids)=309AA_BP=193
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEET
PAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK
CDLNGRPREAEVRVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKK

--------------------------------------------------------------
>61740_61740_3_OS9-YEATS4_OS9_chr12_58090156_ENST00000315970_YEATS4_chr12_69764486_ENST00000247843_length(transcript)=1451nt_BP=620nt
AGGGCGGAAACAGATTCTCTGCATAAGAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGG
GACTCCTGTTACCCGCAAGTCTGACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGC
CGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAG
CTGGAGCTATTCACTTCCAGCGTGAAAGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAG
ATGCTCCCTGCTTGCTGAAGACAAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAG
AGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTC
TTAAACGCTACCACAGCCAGACCTATGGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGGTAACCCTGT
ATCATTTGCTAAAGCTGTTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTC
AAGACCCAACAGCAATGATGCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGC
TTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTC
GTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTT
GGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATAT
ACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTA
TATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCACAGTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTAT
TACCCTTTTGACAGGCATCAAAATTTCATTATAAAGTATTACTTGTACAAATTTTGTACTTCTTTAGTGGCTAGAATTAGTGAAGAAACT
TAATGTGTATATTTAATTTCTTCAAGTTCTTACCTGCCCCCATCCTTTTTTGTATATGATGTGTCCAGTAAGTATTCAATAAATGTAGTT

>61740_61740_3_OS9-YEATS4_OS9_chr12_58090156_ENST00000315970_YEATS4_chr12_69764486_ENST00000247843_length(amino acids)=309AA_BP=193
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEET
PAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK
CDLNGRPREAEVRVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKK

--------------------------------------------------------------
>61740_61740_4_OS9-YEATS4_OS9_chr12_58090156_ENST00000315970_YEATS4_chr12_69764486_ENST00000548020_length(transcript)=1286nt_BP=620nt
AGGGCGGAAACAGATTCTCTGCATAAGAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGG
GACTCCTGTTACCCGCAAGTCTGACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGC
CGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAG
CTGGAGCTATTCACTTCCAGCGTGAAAGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAG
ATGCTCCCTGCTTGCTGAAGACAAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAG
AGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTC
TTAAACGCTACCACAGCCAGACCTATGGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGGTAACCCTGT
ATCATTTGCTAAAGCTGTTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTC
AAGACCCAACAGCAATGATGCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGC
TTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTC
GTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTT
GGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATAT
ACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTA
TATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCACAGTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTAT

>61740_61740_4_OS9-YEATS4_OS9_chr12_58090156_ENST00000315970_YEATS4_chr12_69764486_ENST00000548020_length(amino acids)=309AA_BP=193
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEET
PAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK
CDLNGRPREAEVRVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKK

--------------------------------------------------------------
>61740_61740_5_OS9-YEATS4_OS9_chr12_58090156_ENST00000389142_YEATS4_chr12_69764486_ENST00000247843_length(transcript)=1425nt_BP=594nt
GAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGACTCCTGTTACCCGCAAGTCTGACC
GGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCAGAGC
CAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAA
AGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGACAAAG
GACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAGAGATCAAAGGTGAAGTCCTCTATCTC
GGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTAT
GGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGGTAACCCTGTATCATTTGCTAAAGCTGTTTCAATCA
GACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATGATGCAACAA
TTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTA
GAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAAT
GAAATCAGAAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGG
TGGGCTTCACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAG
CAATAGGAATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTA
AGAAAATTCTATGATATTAAGCACAGTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATCAAAATTT
CATTATAAAGTATTACTTGTACAAATTTTGTACTTCTTTAGTGGCTAGAATTAGTGAAGAAACTTAATGTGTATATTTAATTTCTTCAAG

>61740_61740_5_OS9-YEATS4_OS9_chr12_58090156_ENST00000389142_YEATS4_chr12_69764486_ENST00000247843_length(amino acids)=309AA_BP=193
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEET
PAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK
CDLNGRPREAEVRVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKK

--------------------------------------------------------------
>61740_61740_6_OS9-YEATS4_OS9_chr12_58090156_ENST00000389142_YEATS4_chr12_69764486_ENST00000548020_length(transcript)=1260nt_BP=594nt
GAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGACTCCTGTTACCCGCAAGTCTGACC
GGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCAGAGC
CAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAA
AGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGACAAAG
GACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAGAGATCAAAGGTGAAGTCCTCTATCTC
GGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTAT
GGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGGTAACCCTGTATCATTTGCTAAAGCTGTTTCAATCA
GACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATGATGCAACAA
TTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTA
GAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAAT
GAAATCAGAAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGG
TGGGCTTCACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAG
CAATAGGAATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTA
AGAAAATTCTATGATATTAAGCACAGTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATCAAAATTT

>61740_61740_6_OS9-YEATS4_OS9_chr12_58090156_ENST00000389142_YEATS4_chr12_69764486_ENST00000548020_length(amino acids)=309AA_BP=193
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEET
PAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK
CDLNGRPREAEVRVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKK

--------------------------------------------------------------
>61740_61740_7_OS9-YEATS4_OS9_chr12_58090156_ENST00000389146_YEATS4_chr12_69764486_ENST00000247843_length(transcript)=1427nt_BP=596nt
AAGAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGACTCCTGTTACCCGCAAGTCTGA
CCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCAGA
GCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTG
AAAGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGACAA
AGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAGAGATCAAAGGTGAAGTCCTCTATC
TCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCT
ATGGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGGTAACCCTGTATCATTTGCTAAAGCTGTTTCAAT
CAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATGATGCAAC
AATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAAT
TAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAA
ATGAAATCAGAAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAA
GGTGGGCTTCACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTT
AGCAATAGGAATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTT
TAAGAAAATTCTATGATATTAAGCACAGTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATCAAAAT
TTCATTATAAAGTATTACTTGTACAAATTTTGTACTTCTTTAGTGGCTAGAATTAGTGAAGAAACTTAATGTGTATATTTAATTTCTTCA

>61740_61740_7_OS9-YEATS4_OS9_chr12_58090156_ENST00000389146_YEATS4_chr12_69764486_ENST00000247843_length(amino acids)=309AA_BP=193
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEET
PAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK
CDLNGRPREAEVRVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKK

--------------------------------------------------------------
>61740_61740_8_OS9-YEATS4_OS9_chr12_58090156_ENST00000389146_YEATS4_chr12_69764486_ENST00000548020_length(transcript)=1262nt_BP=596nt
AAGAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGACTCCTGTTACCCGCAAGTCTGA
CCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCAGA
GCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTG
AAAGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGACAA
AGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAGAGATCAAAGGTGAAGTCCTCTATC
TCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCT
ATGGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGGTAACCCTGTATCATTTGCTAAAGCTGTTTCAAT
CAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATGATGCAAC
AATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAAT
TAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAA
ATGAAATCAGAAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAA
GGTGGGCTTCACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTT
AGCAATAGGAATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTT
TAAGAAAATTCTATGATATTAAGCACAGTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATCAAAAT

>61740_61740_8_OS9-YEATS4_OS9_chr12_58090156_ENST00000389146_YEATS4_chr12_69764486_ENST00000548020_length(amino acids)=309AA_BP=193
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEET
PAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK
CDLNGRPREAEVRVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKK

--------------------------------------------------------------
>61740_61740_9_OS9-YEATS4_OS9_chr12_58090156_ENST00000439210_YEATS4_chr12_69764486_ENST00000247843_length(transcript)=1252nt_BP=421nt
ATAAGAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGACTCCTGTTACCCGCAAGTCT
GACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCA
GACAAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAGAGATCAAAGGTGAAGTCCT
CTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCA
GACCTATGGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGGTAACCCTGTATCATTTGCTAAAGCTGTT
TCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATGAT
GCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTGAAAACCAGAGA
AAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTT
AAAAAATGAAATCAGAAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAA
AATAAGGTGGGCTTCACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAAT
TTCTTAGCAATAGGAATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACC
CATTTTAAGAAAATTCTATGATATTAAGCACAGTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATC
AAAATTTCATTATAAAGTATTACTTGTACAAATTTTGTACTTCTTTAGTGGCTAGAATTAGTGAAGAAACTTAATGTGTATATTTAATTT

>61740_61740_9_OS9-YEATS4_OS9_chr12_58090156_ENST00000439210_YEATS4_chr12_69764486_ENST00000247843_length(amino acids)=250AA_BP=134
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQ
SAFDWDDETAKASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTT

--------------------------------------------------------------
>61740_61740_10_OS9-YEATS4_OS9_chr12_58090156_ENST00000439210_YEATS4_chr12_69764486_ENST00000548020_length(transcript)=1087nt_BP=421nt
ATAAGAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGACTCCTGTTACCCGCAAGTCT
GACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCA
GACAAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAGAGATCAAAGGTGAAGTCCT
CTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCA
GACCTATGGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGGTAACCCTGTATCATTTGCTAAAGCTGTT
TCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATGAT
GCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTGAAAACCAGAGA
AAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTT
AAAAAATGAAATCAGAAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAA
AATAAGGTGGGCTTCACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAAT
TTCTTAGCAATAGGAATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACC
CATTTTAAGAAAATTCTATGATATTAAGCACAGTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATC

>61740_61740_10_OS9-YEATS4_OS9_chr12_58090156_ENST00000439210_YEATS4_chr12_69764486_ENST00000548020_length(amino acids)=250AA_BP=134
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQ
SAFDWDDETAKASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTT

--------------------------------------------------------------
>61740_61740_11_OS9-YEATS4_OS9_chr12_58090156_ENST00000552285_YEATS4_chr12_69764486_ENST00000247843_length(transcript)=1617nt_BP=786nt
CTGACCAATCACGGACAGCGATTGATATTTCTAATCGTCGTGATCCACCTCCCCAGGACCTTGGAGCCACGTTTACAAATAGGAATAGGG
TACGTGGGAGGGATAGAACGTACAGCCAATAAAATCATGTGGCGCCGATGGGCGTGTTGAGGCCGCTGCCTGGCTTAGGGCGGAAACAGA
TTCTCTGCATAAGAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGACTCCTGTTACCC
GCAAGTCTGACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGCCGTTGCCTGTCATG
GGAGGGCAGAGCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCAC
TTCCAGCGTGAAAGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTG
CTGAAGACAAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAGAGATCAAAGGTGAA
GTCCTCTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCAC
AGCCAGACCTATGGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGGTAACCCTGTATCATTTGCTAAAG
CTGTTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCA
ATGATGCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTGAAAACC
AGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAAT
TGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAA
CTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCA
TGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTAC
CAACCCATTTTAAGAAAATTCTATGATATTAAGCACAGTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAG
GCATCAAAATTTCATTATAAAGTATTACTTGTACAAATTTTGTACTTCTTTAGTGGCTAGAATTAGTGAAGAAACTTAATGTGTATATTT

>61740_61740_11_OS9-YEATS4_OS9_chr12_58090156_ENST00000552285_YEATS4_chr12_69764486_ENST00000247843_length(amino acids)=309AA_BP=193
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEET
PAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK
CDLNGRPREAEVRVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKK

--------------------------------------------------------------
>61740_61740_12_OS9-YEATS4_OS9_chr12_58090156_ENST00000552285_YEATS4_chr12_69764486_ENST00000548020_length(transcript)=1452nt_BP=786nt
CTGACCAATCACGGACAGCGATTGATATTTCTAATCGTCGTGATCCACCTCCCCAGGACCTTGGAGCCACGTTTACAAATAGGAATAGGG
TACGTGGGAGGGATAGAACGTACAGCCAATAAAATCATGTGGCGCCGATGGGCGTGTTGAGGCCGCTGCCTGGCTTAGGGCGGAAACAGA
TTCTCTGCATAAGAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGACTCCTGTTACCC
GCAAGTCTGACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGCCGTTGCCTGTCATG
GGAGGGCAGAGCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCAC
TTCCAGCGTGAAAGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTG
CTGAAGACAAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAGAGATCAAAGGTGAA
GTCCTCTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCAC
AGCCAGACCTATGGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGGTAACCCTGTATCATTTGCTAAAG
CTGTTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCA
ATGATGCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTGAAAACC
AGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAAT
TGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAA
CTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCA
TGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTAC
CAACCCATTTTAAGAAAATTCTATGATATTAAGCACAGTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAG

>61740_61740_12_OS9-YEATS4_OS9_chr12_58090156_ENST00000552285_YEATS4_chr12_69764486_ENST00000548020_length(amino acids)=309AA_BP=193
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEET
PAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK
CDLNGRPREAEVRVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for OS9-YEATS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneYEATS4chr12:58090156chr12:69764486ENST0000024784337163_227111.0228.0MLLT10
TgeneYEATS4chr12:58090156chr12:69764486ENST0000024784337168_227111.0228.0TACC1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for OS9-YEATS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for OS9-YEATS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource