FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:OSBPL1A-FBRS (FusionGDB2 ID:61783)

Fusion Gene Summary for OSBPL1A-FBRS

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL1A-FBRS
Fusion gene ID: 61783
HgeneTgene
Gene symbol

OSBPL1A

FBRS

Gene ID

114876

64319

Gene nameoxysterol binding protein like 1Afibrosin
SynonymsORP-1|ORP1|OSBPL1BFBS|FBS1
Cytomap

18q11.2

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 1OSBP-related protein 1oxysterol binding protein-like 1Boxysterol-binding protein-related protein 1 variant 1oxysterol-binding protein-related protein 1 variant 2probable fibrosin-1fibrogenic lymphokinefibrosin 1probable fibrosin-1 long transcript protein
Modification date2020031320200313
UniProtAcc.

Q9HCM7

Ensembl transtripts involved in fusion geneENST00000319481, ENST00000399441, 
ENST00000582618, ENST00000357041, 
ENST00000399443, 		ENST00000287468, 
ENST00000395073, ENST00000482749, 
ENST00000568722, ENST00000356166, 
Fusion gene scores* DoF score16 X 16 X 7=17924 X 5 X 3=60
# samples 175
** MAII scorelog2(17/1792*10)=-3.3979639859199
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OSBPL1A [Title/Abstract] AND FBRS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOSBPL1A(21957377)-FBRS(30676036), # samples:1
OSBPL1A(21957376)-FBRS(30676035), # samples:1
Anticipated loss of major functional domain due to fusion event.OSBPL1A-FBRS seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
OSBPL1A-FBRS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across OSBPL1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBRS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5725-01AOSBPL1Achr18

21957377

-FBRSchr16

30676036

+
ChimerDB4STADTCGA-CG-5725OSBPL1Achr18

21957376

-FBRSchr16

30676035

+


Top

Fusion Gene ORF analysis for OSBPL1A-FBRS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000319481ENST00000287468OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
5CDS-5UTRENST00000319481ENST00000287468OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
5CDS-5UTRENST00000319481ENST00000395073OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
5CDS-5UTRENST00000319481ENST00000395073OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
5CDS-5UTRENST00000399441ENST00000287468OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
5CDS-5UTRENST00000399441ENST00000287468OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
5CDS-5UTRENST00000399441ENST00000395073OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
5CDS-5UTRENST00000399441ENST00000395073OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
5CDS-intronENST00000319481ENST00000482749OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
5CDS-intronENST00000319481ENST00000482749OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
5CDS-intronENST00000319481ENST00000568722OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
5CDS-intronENST00000319481ENST00000568722OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
5CDS-intronENST00000399441ENST00000482749OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
5CDS-intronENST00000399441ENST00000482749OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
5CDS-intronENST00000399441ENST00000568722OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
5CDS-intronENST00000399441ENST00000568722OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
5UTR-3CDSENST00000582618ENST00000356166OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
5UTR-3CDSENST00000582618ENST00000356166OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
5UTR-5UTRENST00000582618ENST00000287468OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
5UTR-5UTRENST00000582618ENST00000287468OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
5UTR-5UTRENST00000582618ENST00000395073OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
5UTR-5UTRENST00000582618ENST00000395073OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
5UTR-intronENST00000582618ENST00000482749OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
5UTR-intronENST00000582618ENST00000482749OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
5UTR-intronENST00000582618ENST00000568722OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
5UTR-intronENST00000582618ENST00000568722OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
Frame-shiftENST00000319481ENST00000356166OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
Frame-shiftENST00000319481ENST00000356166OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
In-frameENST00000399441ENST00000356166OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
In-frameENST00000399441ENST00000356166OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
intron-3CDSENST00000357041ENST00000356166OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
intron-3CDSENST00000357041ENST00000356166OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
intron-3CDSENST00000399443ENST00000356166OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
intron-3CDSENST00000399443ENST00000356166OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
intron-5UTRENST00000357041ENST00000287468OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
intron-5UTRENST00000357041ENST00000287468OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
intron-5UTRENST00000357041ENST00000395073OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
intron-5UTRENST00000357041ENST00000395073OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
intron-5UTRENST00000399443ENST00000287468OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
intron-5UTRENST00000399443ENST00000287468OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
intron-5UTRENST00000399443ENST00000395073OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
intron-5UTRENST00000399443ENST00000395073OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
intron-intronENST00000357041ENST00000482749OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
intron-intronENST00000357041ENST00000482749OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
intron-intronENST00000357041ENST00000568722OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
intron-intronENST00000357041ENST00000568722OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
intron-intronENST00000399443ENST00000482749OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
intron-intronENST00000399443ENST00000482749OSBPL1Achr18

21957376

-FBRSchr16

30676035

+
intron-intronENST00000399443ENST00000568722OSBPL1Achr18

21957377

-FBRSchr16

30676036

+
intron-intronENST00000399443ENST00000568722OSBPL1Achr18

21957376

-FBRSchr16

30676035

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000399441OSBPL1Achr1821957377-ENST00000356166FBRSchr1630676036+30943392031924573
ENST00000399441OSBPL1Achr1821957376-ENST00000356166FBRSchr1630676035+30943392031924573

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000399441ENST00000356166OSBPL1Achr1821957377-FBRSchr1630676036+0.093674980.906325
ENST00000399441ENST00000356166OSBPL1Achr1821957376-FBRSchr1630676035+0.093674980.906325

Top

Fusion Genomic Features for OSBPL1A-FBRS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
OSBPL1Achr1821957376-FBRSchr1630676035+0.000775440.99922454
OSBPL1Achr1821957376-FBRSchr1630676035+0.000775440.99922454
OSBPL1Achr1821957376-FBRSchr1630676035+0.000775440.99922454
OSBPL1Achr1821957376-FBRSchr1630676035+0.000775440.99922454

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for OSBPL1A-FBRS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:21957377/chr16:30676036)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FBRS

Q9HCM7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFBRSchr18:21957376chr16:30676035ENST00000287468012311_3290461.0Compositional biasNote=Ala-rich
TgeneFBRSchr18:21957376chr16:30676035ENST00000287468012342_4220461.0Compositional biasNote=Pro-rich
TgeneFBRSchr18:21957376chr16:30676035ENST00000568722010311_3290373.0Compositional biasNote=Ala-rich
TgeneFBRSchr18:21957376chr16:30676035ENST00000568722010342_4220373.0Compositional biasNote=Pro-rich
TgeneFBRSchr18:21957377chr16:30676036ENST00000287468012311_3290461.0Compositional biasNote=Ala-rich
TgeneFBRSchr18:21957377chr16:30676036ENST00000287468012342_4220461.0Compositional biasNote=Pro-rich
TgeneFBRSchr18:21957377chr16:30676036ENST00000568722010311_3290373.0Compositional biasNote=Ala-rich
TgeneFBRSchr18:21957377chr16:30676036ENST00000568722010342_4220373.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000319481-228430_46340951.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000319481-228877_91340951.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000357041-116430_4630569.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000357041-116877_9130569.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000399443-114430_4630438.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000399443-114877_9130438.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000319481-228430_46340951.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000319481-228877_91340951.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000357041-116430_4630569.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000357041-116877_9130569.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000399443-114430_4630438.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000399443-114877_9130438.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000319481-228235_33440951.0DomainPH
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000357041-116235_3340569.0DomainPH
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000399443-114235_3340438.0DomainPH
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000319481-228235_33440951.0DomainPH
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000357041-116235_3340569.0DomainPH
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000399443-114235_3340438.0DomainPH
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000319481-228469_48340951.0MotifFFAT
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000357041-116469_4830569.0MotifFFAT
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000399443-114469_4830438.0MotifFFAT
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000319481-228469_48340951.0MotifFFAT
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000357041-116469_4830569.0MotifFFAT
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000399443-114469_4830438.0MotifFFAT
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000319481-228175_20440951.0RepeatNote=ANK 3
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000319481-22847_7640951.0RepeatNote=ANK 1
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000319481-22880_10940951.0RepeatNote=ANK 2
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000357041-116175_2040569.0RepeatNote=ANK 3
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000357041-11647_760569.0RepeatNote=ANK 1
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000357041-11680_1090569.0RepeatNote=ANK 2
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000399443-114175_2040438.0RepeatNote=ANK 3
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000399443-11447_760438.0RepeatNote=ANK 1
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000399443-11480_1090438.0RepeatNote=ANK 2
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000319481-228175_20440951.0RepeatNote=ANK 3
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000319481-22847_7640951.0RepeatNote=ANK 1
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000319481-22880_10940951.0RepeatNote=ANK 2
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000357041-116175_2040569.0RepeatNote=ANK 3
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000357041-11647_760569.0RepeatNote=ANK 1
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000357041-11680_1090569.0RepeatNote=ANK 2
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000399443-114175_2040438.0RepeatNote=ANK 3
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000399443-11447_760438.0RepeatNote=ANK 1
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000399443-11480_1090438.0RepeatNote=ANK 2


Top

Fusion Gene Sequence for OSBPL1A-FBRS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61783_61783_1_OSBPL1A-FBRS_OSBPL1A_chr18_21957376_ENST00000399441_FBRS_chr16_30676035_ENST00000356166_length(transcript)=3094nt_BP=339nt
GCGGGCTCGAGCGTCCTCGGGGAGTGCCAGCCAGAGTTGGTGACGACCACTTCCTCGACGTGGGGCGGGCGGACGGGAAGCCTGGGGTCG
TGGCCACCGCCTCGGGAGCTCTGGGAGCCCGGGTGACCGCGTAGGTCAGTTTCTCGCGGCTGTCCACGCCTGGAGTTCGAGGCCGGTTCC
CGCGCTGACGGGTTCCCGCCGGGCTGCGCTCGGGAGAAATGAACACAGAAGCGGAGCAACAGCTTCTCCATCACGCCAGAAATGGCAATG
CTGAAGAAGTAAGACAACTATTAGAGACCATGGCGAGGAATGAAGTGATTGCTGACATTAATTGCAAAGAGCAGGACCTGATCGGCCAGG
ACCTGAACTCTCGCTACCTGAATGCCCAGGGTGGCCCTGAGGTGGTGGGGGCAGGGGGCTCGGCCCGGCCCCTGGCCTTCCAGTTCCACC
AGCACAACCACCAGCACCAGCACACCCACCAGCACACCCACCAGCACTTCACCCCTTATCCCCCGGGCCTGCTGCCACCCCACGGCCCCC
ACATGTTTGAGAAATATCCAGGAAAGATGGAAGGCCTTTTCCGACATAATCCGTACACGGCCTTCCCTCCCGCAGTGCCCGGGCTGCCTC
CGGGCCTCCCGCCGGCCGTCTCCTTTGGCTCCCTGCAGGGGGCCTTCCAGCCCAAGAGCACGAACCCTGAGCTGCCACCACGACTGGGGC
CGGTGCCGAGCGGGCTCTCCCAGAAGGGGACACAGATCCCCGACCATTTCCGGCCACCTTTGAGGAAACCAGGGAAGTGGTGTGCCATGC
ACGTGCGTGTGGCTTACATGATCCTGAGACACCAGGAGAAAATGAAGGGTGACTCCCACAAGCTTGACTTTCGGAATGACCTCCTGCCCT
GCCTTCCGGGGCCCTATGGGGCCCTGCCCCCTGGGCAGGAGCTCTCCCACCCGGCCTCCCTCTTCACTGCGACTGGTGCCGTCCACGCTG
CAGCCAACCCTTTCACGGCAGCTCCCGGGGCCCACGGACCCTTCCTGAGCCCCAGCACCCACATTGATCCCTTTGGGCGTCCCACAAGCT
TCGCCTCTTTGGCTGCCCTCTCCAACGGGGCCTTTGGAGGCCTGGGCAGCCCCACATTCAACTCCGGCGCCGTCTTTGCCCAGAAAGAAA
GCCCAGGGGCCCCACCAGCCTTCGCCTCCCCACCGGACCCATGGGGCCGCCTGCACCGCAGTCCTCTGACCTTTCCTGCCTGGGTCCGGC
CCCCTGAGGCCGCCCGGACTCCAGGCTCAGACAAGGAGCGGCCTGTGGAGCGGAGGGAGCCCTCCATCACCAAGGAGGAGAAGGACAGGG
ACCTCCCCTTCTCACGGCCCCAGCTCCGAGTTTCTCCTGCTACTCCCAAGGCCCGGGCTGGTGAGGAGGGGCCTCGGCCAACCAAGGAAT
CTGTGCGGGTAAAGGAAGAGCGGAAGGAGGAGGCTGCCGCCGCCGCTGCCGCTGCTGCTGCCGCCGCCGCTGCCGCCGCCGCAGCAGCCA
CTGGGCCCCAGGGCCTTCACCTGCTGTTTGAGAGGCCCCGGCCGCCCCCGTTTCTGGGCCCTAGCCCACCAGATCGCTGTGCTGGCTTCC
TGGAGCCAACCTGGTTGGCAGCACCCCCACGCCTGGCAAGGCCACCCCGCTTCTATGAGGCGGGTGAGGAGCTAACTGGACCCGGGGCCG
TGGCCGCTGCCCGCCTCTACGGTCTGGAACCTGCTCACCCCTTGCTCTACAGCCGCTTGGCTCCTCCACCACCACCTGCTGCGGCCCCGG
GAACCCCTCACCTTCTCAGCAAGACCCCACCGGGAGCCCTTTTGGGGGCACCACCTCCGCTTGTGCCCGCCCCCCGGCCCAGTTCCCCAC
CTAGGGGCCCTGGCCCAGCTCGGGCTGACAGGTGAGGGGAACGGGGGGGGGTCGGGGCAAAGCTCCATCTCCCCTTCCTTTAACCAGGTC
CTAGGGCTGAGGTTTTAAGCCAGGGCTGGAGGGCAAAGGTCATAACCTCACCAGCCACCTCTGAGGTCATGGAACCTGGGAACAGAAGCC
TCAACCCCCACAAGACCAAGCATCACATGGAGTGTAGGGTCACTGGGAGAGCAGAGGTCACAGCCTCTAGAGAAGGGAGAGGGGCGTGTG
CATGGGAGTGTGGCTCATCTCGGGGGCCATGGGGCCTCCTGAGGTACACCTTTGCCCCTGTAAGGGCCTCTAGGCCCTGGGCCTGCCTCC
CCAAGGGCTCACTAAGCCAGAGGCCAAAGTGCCCCCTCCCGTTCACCTACCACCCAAGTCCTCATGCCCTCCGAGGGCTGGGGGAGGAGG
GGCTCAAGGAAGGGGGGTTCCATGTACATATTTATCACCCCTTTCACATAGCCCCAAGACCTTTTGTACATTTTTACAGGGGTGCCCCTC
CCAACAGTTCCCTTCCTGGTTAATTAAACCCTCAGACTGGTGCTGTGTTCCTAGCCTCTGGCCTCTCTGTGGGGAAAGGGGACTGCAGGG
GGAAGAGCCGGGAAGGGACAGTCAGGCTTCTCCCTGGGAAGGTGGGGCCAGCAGGAGATGACCAACAGGGGGCAGGACCTGGGGACCTGG
GCTGGAGGGAAGGGCAGAAGCTTCCTACTTGGCTGACAGCCCCGGTTCCCCCAACATGTTCCCGTTCACTCTGCCCCCACCCCCAAAGGC
TCAGCCTCTAAATCTCAGACTCCACCACCTCTTAATGGCTCAGTCCCCTTCACCCCATTTCCAAGTGCCCCCAGGACTCCTGGGCCCTGC
TTCCCTGAACCCTGTTCTCCAAAACCCTGCCCCAGGCTAAGGGTGGCCAGAGAAGGTCACCATGTACCACACACCAAAGAAGGGGGTCGG
CCCAGGGGTGGGCGACACAGGCAGCTTCTTCGGCAGCCTCACGGCAGCAACCCCAGCCTTCCCAAAGCAGCAGGCGCCTCCAGGCTGGGG
CCCAACCTAGAAGGCAGGGGTCAATCTAACAAAACCCTAACGTTGACTTTTTTCCCTGGTGGGGCTTCTTCTGTAACATGACTTGCGAAT

>61783_61783_1_OSBPL1A-FBRS_OSBPL1A_chr18_21957376_ENST00000399441_FBRS_chr16_30676035_ENST00000356166_length(amino acids)=573AA_BP=45
MRSGEMNTEAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKEQDLIGQDLNSRYLNAQGGPEVVGAGGSARPLAFQFHQHNHQHQH
THQHTHQHFTPYPPGLLPPHGPHMFEKYPGKMEGLFRHNPYTAFPPAVPGLPPGLPPAVSFGSLQGAFQPKSTNPELPPRLGPVPSGLSQ
KGTQIPDHFRPPLRKPGKWCAMHVRVAYMILRHQEKMKGDSHKLDFRNDLLPCLPGPYGALPPGQELSHPASLFTATGAVHAAANPFTAA
PGAHGPFLSPSTHIDPFGRPTSFASLAALSNGAFGGLGSPTFNSGAVFAQKESPGAPPAFASPPDPWGRLHRSPLTFPAWVRPPEAARTP
GSDKERPVERREPSITKEEKDRDLPFSRPQLRVSPATPKARAGEEGPRPTKESVRVKEERKEEAAAAAAAAAAAAAAAAAAATGPQGLHL
LFERPRPPPFLGPSPPDRCAGFLEPTWLAAPPRLARPPRFYEAGEELTGPGAVAAARLYGLEPAHPLLYSRLAPPPPPAAAPGTPHLLSK

--------------------------------------------------------------
>61783_61783_2_OSBPL1A-FBRS_OSBPL1A_chr18_21957377_ENST00000399441_FBRS_chr16_30676036_ENST00000356166_length(transcript)=3094nt_BP=339nt
GCGGGCTCGAGCGTCCTCGGGGAGTGCCAGCCAGAGTTGGTGACGACCACTTCCTCGACGTGGGGCGGGCGGACGGGAAGCCTGGGGTCG
TGGCCACCGCCTCGGGAGCTCTGGGAGCCCGGGTGACCGCGTAGGTCAGTTTCTCGCGGCTGTCCACGCCTGGAGTTCGAGGCCGGTTCC
CGCGCTGACGGGTTCCCGCCGGGCTGCGCTCGGGAGAAATGAACACAGAAGCGGAGCAACAGCTTCTCCATCACGCCAGAAATGGCAATG
CTGAAGAAGTAAGACAACTATTAGAGACCATGGCGAGGAATGAAGTGATTGCTGACATTAATTGCAAAGAGCAGGACCTGATCGGCCAGG
ACCTGAACTCTCGCTACCTGAATGCCCAGGGTGGCCCTGAGGTGGTGGGGGCAGGGGGCTCGGCCCGGCCCCTGGCCTTCCAGTTCCACC
AGCACAACCACCAGCACCAGCACACCCACCAGCACACCCACCAGCACTTCACCCCTTATCCCCCGGGCCTGCTGCCACCCCACGGCCCCC
ACATGTTTGAGAAATATCCAGGAAAGATGGAAGGCCTTTTCCGACATAATCCGTACACGGCCTTCCCTCCCGCAGTGCCCGGGCTGCCTC
CGGGCCTCCCGCCGGCCGTCTCCTTTGGCTCCCTGCAGGGGGCCTTCCAGCCCAAGAGCACGAACCCTGAGCTGCCACCACGACTGGGGC
CGGTGCCGAGCGGGCTCTCCCAGAAGGGGACACAGATCCCCGACCATTTCCGGCCACCTTTGAGGAAACCAGGGAAGTGGTGTGCCATGC
ACGTGCGTGTGGCTTACATGATCCTGAGACACCAGGAGAAAATGAAGGGTGACTCCCACAAGCTTGACTTTCGGAATGACCTCCTGCCCT
GCCTTCCGGGGCCCTATGGGGCCCTGCCCCCTGGGCAGGAGCTCTCCCACCCGGCCTCCCTCTTCACTGCGACTGGTGCCGTCCACGCTG
CAGCCAACCCTTTCACGGCAGCTCCCGGGGCCCACGGACCCTTCCTGAGCCCCAGCACCCACATTGATCCCTTTGGGCGTCCCACAAGCT
TCGCCTCTTTGGCTGCCCTCTCCAACGGGGCCTTTGGAGGCCTGGGCAGCCCCACATTCAACTCCGGCGCCGTCTTTGCCCAGAAAGAAA
GCCCAGGGGCCCCACCAGCCTTCGCCTCCCCACCGGACCCATGGGGCCGCCTGCACCGCAGTCCTCTGACCTTTCCTGCCTGGGTCCGGC
CCCCTGAGGCCGCCCGGACTCCAGGCTCAGACAAGGAGCGGCCTGTGGAGCGGAGGGAGCCCTCCATCACCAAGGAGGAGAAGGACAGGG
ACCTCCCCTTCTCACGGCCCCAGCTCCGAGTTTCTCCTGCTACTCCCAAGGCCCGGGCTGGTGAGGAGGGGCCTCGGCCAACCAAGGAAT
CTGTGCGGGTAAAGGAAGAGCGGAAGGAGGAGGCTGCCGCCGCCGCTGCCGCTGCTGCTGCCGCCGCCGCTGCCGCCGCCGCAGCAGCCA
CTGGGCCCCAGGGCCTTCACCTGCTGTTTGAGAGGCCCCGGCCGCCCCCGTTTCTGGGCCCTAGCCCACCAGATCGCTGTGCTGGCTTCC
TGGAGCCAACCTGGTTGGCAGCACCCCCACGCCTGGCAAGGCCACCCCGCTTCTATGAGGCGGGTGAGGAGCTAACTGGACCCGGGGCCG
TGGCCGCTGCCCGCCTCTACGGTCTGGAACCTGCTCACCCCTTGCTCTACAGCCGCTTGGCTCCTCCACCACCACCTGCTGCGGCCCCGG
GAACCCCTCACCTTCTCAGCAAGACCCCACCGGGAGCCCTTTTGGGGGCACCACCTCCGCTTGTGCCCGCCCCCCGGCCCAGTTCCCCAC
CTAGGGGCCCTGGCCCAGCTCGGGCTGACAGGTGAGGGGAACGGGGGGGGGTCGGGGCAAAGCTCCATCTCCCCTTCCTTTAACCAGGTC
CTAGGGCTGAGGTTTTAAGCCAGGGCTGGAGGGCAAAGGTCATAACCTCACCAGCCACCTCTGAGGTCATGGAACCTGGGAACAGAAGCC
TCAACCCCCACAAGACCAAGCATCACATGGAGTGTAGGGTCACTGGGAGAGCAGAGGTCACAGCCTCTAGAGAAGGGAGAGGGGCGTGTG
CATGGGAGTGTGGCTCATCTCGGGGGCCATGGGGCCTCCTGAGGTACACCTTTGCCCCTGTAAGGGCCTCTAGGCCCTGGGCCTGCCTCC
CCAAGGGCTCACTAAGCCAGAGGCCAAAGTGCCCCCTCCCGTTCACCTACCACCCAAGTCCTCATGCCCTCCGAGGGCTGGGGGAGGAGG
GGCTCAAGGAAGGGGGGTTCCATGTACATATTTATCACCCCTTTCACATAGCCCCAAGACCTTTTGTACATTTTTACAGGGGTGCCCCTC
CCAACAGTTCCCTTCCTGGTTAATTAAACCCTCAGACTGGTGCTGTGTTCCTAGCCTCTGGCCTCTCTGTGGGGAAAGGGGACTGCAGGG
GGAAGAGCCGGGAAGGGACAGTCAGGCTTCTCCCTGGGAAGGTGGGGCCAGCAGGAGATGACCAACAGGGGGCAGGACCTGGGGACCTGG
GCTGGAGGGAAGGGCAGAAGCTTCCTACTTGGCTGACAGCCCCGGTTCCCCCAACATGTTCCCGTTCACTCTGCCCCCACCCCCAAAGGC
TCAGCCTCTAAATCTCAGACTCCACCACCTCTTAATGGCTCAGTCCCCTTCACCCCATTTCCAAGTGCCCCCAGGACTCCTGGGCCCTGC
TTCCCTGAACCCTGTTCTCCAAAACCCTGCCCCAGGCTAAGGGTGGCCAGAGAAGGTCACCATGTACCACACACCAAAGAAGGGGGTCGG
CCCAGGGGTGGGCGACACAGGCAGCTTCTTCGGCAGCCTCACGGCAGCAACCCCAGCCTTCCCAAAGCAGCAGGCGCCTCCAGGCTGGGG
CCCAACCTAGAAGGCAGGGGTCAATCTAACAAAACCCTAACGTTGACTTTTTTCCCTGGTGGGGCTTCTTCTGTAACATGACTTGCGAAT

>61783_61783_2_OSBPL1A-FBRS_OSBPL1A_chr18_21957377_ENST00000399441_FBRS_chr16_30676036_ENST00000356166_length(amino acids)=573AA_BP=45
MRSGEMNTEAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKEQDLIGQDLNSRYLNAQGGPEVVGAGGSARPLAFQFHQHNHQHQH
THQHTHQHFTPYPPGLLPPHGPHMFEKYPGKMEGLFRHNPYTAFPPAVPGLPPGLPPAVSFGSLQGAFQPKSTNPELPPRLGPVPSGLSQ
KGTQIPDHFRPPLRKPGKWCAMHVRVAYMILRHQEKMKGDSHKLDFRNDLLPCLPGPYGALPPGQELSHPASLFTATGAVHAAANPFTAA
PGAHGPFLSPSTHIDPFGRPTSFASLAALSNGAFGGLGSPTFNSGAVFAQKESPGAPPAFASPPDPWGRLHRSPLTFPAWVRPPEAARTP
GSDKERPVERREPSITKEEKDRDLPFSRPQLRVSPATPKARAGEEGPRPTKESVRVKEERKEEAAAAAAAAAAAAAAAAAAATGPQGLHL
LFERPRPPPFLGPSPPDRCAGFLEPTWLAAPPRLARPPRFYEAGEELTGPGAVAAARLYGLEPAHPLLYSRLAPPPPPAAAPGTPHLLSK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for OSBPL1A-FBRS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000319481-2281_23740.333333333333336951.0RAB7A
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000357041-1161_2370569.0RAB7A
HgeneOSBPL1Achr18:21957376chr16:30676035ENST00000399443-1141_2370438.0RAB7A
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000319481-2281_23740.333333333333336951.0RAB7A
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000357041-1161_2370569.0RAB7A
HgeneOSBPL1Achr18:21957377chr16:30676036ENST00000399443-1141_2370438.0RAB7A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for OSBPL1A-FBRS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for OSBPL1A-FBRS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource