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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OSBPL1A-MYO16 (FusionGDB2 ID:61786)

Fusion Gene Summary for OSBPL1A-MYO16

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL1A-MYO16
Fusion gene ID: 61786
HgeneTgene
Gene symbol

OSBPL1A

MYO16

Gene ID

114876

23026

Gene nameoxysterol binding protein like 1Amyosin XVI
SynonymsORP-1|ORP1|OSBPL1BMYAP3|MYR8|Myo16b|NYAP3|PPP1R107
Cytomap

18q11.2

13q33.3

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 1OSBP-related protein 1oxysterol binding protein-like 1Boxysterol-binding protein-related protein 1 variant 1oxysterol-binding protein-related protein 1 variant 2unconventional myosin-XVIMYO16 variant proteinmyosin heavy chain Myr 8neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 3protein phosphatase 1, regulatory subunit 10
Modification date2020031320200313
UniProtAcc.

Q9Y6X6

Ensembl transtripts involved in fusion geneENST00000319481, ENST00000357041, 
ENST00000399443, ENST00000399441, 
ENST00000582618, 		ENST00000251041, 
ENST00000357550, ENST00000457511, 
ENST00000467639, ENST00000356711, 
Fusion gene scores* DoF score16 X 16 X 7=179218 X 19 X 10=3420
# samples 1721
** MAII scorelog2(17/1792*10)=-3.3979639859199
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/3420*10)=-4.02553509210714
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OSBPL1A [Title/Abstract] AND MYO16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOSBPL1A(21819184)-MYO16(109772718), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across OSBPL1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYO16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-T3-A92M-01AOSBPL1Achr18

21819184

-MYO16chr13

109772718

+


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Fusion Gene ORF analysis for OSBPL1A-MYO16

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000319481ENST00000251041OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
5CDS-intronENST00000319481ENST00000357550OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
5CDS-intronENST00000319481ENST00000457511OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
5CDS-intronENST00000319481ENST00000467639OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
5CDS-intronENST00000357041ENST00000251041OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
5CDS-intronENST00000357041ENST00000357550OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
5CDS-intronENST00000357041ENST00000457511OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
5CDS-intronENST00000357041ENST00000467639OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
5UTR-3CDSENST00000399443ENST00000356711OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
5UTR-intronENST00000399443ENST00000251041OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
5UTR-intronENST00000399443ENST00000357550OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
5UTR-intronENST00000399443ENST00000457511OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
5UTR-intronENST00000399443ENST00000467639OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
In-frameENST00000319481ENST00000356711OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
In-frameENST00000357041ENST00000356711OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
intron-3CDSENST00000399441ENST00000356711OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
intron-3CDSENST00000582618ENST00000356711OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
intron-intronENST00000399441ENST00000251041OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
intron-intronENST00000399441ENST00000357550OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
intron-intronENST00000399441ENST00000457511OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
intron-intronENST00000399441ENST00000467639OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
intron-intronENST00000582618ENST00000251041OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
intron-intronENST00000582618ENST00000357550OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
intron-intronENST00000582618ENST00000457511OSBPL1Achr18

21819184

-MYO16chr13

109772718

+
intron-intronENST00000582618ENST00000467639OSBPL1Achr18

21819184

-MYO16chr13

109772718

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000319481OSBPL1Achr1821819184-ENST00000356711MYO16chr13109772718+5027165116363855739
ENST00000357041OSBPL1Achr1821819184-ENST00000356711MYO16chr13109772718+37914154002619739

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000319481ENST00000356711OSBPL1Achr1821819184-MYO16chr13109772718+0.0103750290.98962504
ENST00000357041ENST00000356711OSBPL1Achr1821819184-MYO16chr13109772718+0.0093437050.9906563

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Fusion Genomic Features for OSBPL1A-MYO16


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
OSBPL1Achr1821819183-MYO16chr13109772717+0.0005118070.9994881
OSBPL1Achr1821819183-MYO16chr13109772717+0.0005118070.9994881

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for OSBPL1A-MYO16


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:21819184/chr13:109772718)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MYO16

Q9Y6X6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000319481-1628430_463481951.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000319481-1628235_334481951.0DomainPH
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000319481-1628469_483481951.0MotifFFAT
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000319481-1628175_204481951.0RepeatNote=ANK 3
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000319481-162847_76481951.0RepeatNote=ANK 1
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000319481-162880_109481951.0RepeatNote=ANK 2
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000357041-41647_7699569.0RepeatNote=ANK 1
TgeneMYO16chr18:21819184chr13:109772718ENST000002510410241389_16710941.0Compositional biasPro-rich
TgeneMYO16chr18:21819184chr13:109772718ENST0000035671127351389_167111241859.0Compositional biasPro-rich
TgeneMYO16chr18:21819184chr13:109772718ENST0000035755026341389_167111241859.0Compositional biasPro-rich
TgeneMYO16chr18:21819184chr13:109772718ENST000002510410241147_11760941.0DomainIQ
TgeneMYO16chr18:21819184chr13:109772718ENST00000251041024401_11450941.0DomainMyosin motor
TgeneMYO16chr18:21819184chr13:109772718ENST0000035671127351147_117611241859.0DomainIQ
TgeneMYO16chr18:21819184chr13:109772718ENST0000035755026341147_117611241859.0DomainIQ
TgeneMYO16chr18:21819184chr13:109772718ENST00000251041024497_5040941.0Nucleotide bindingATP
TgeneMYO16chr18:21819184chr13:109772718ENST000002510410241111_13770941.0RegionInvolved in CYFIP1- and NCKAP1-binding
TgeneMYO16chr18:21819184chr13:109772718ENST00000251041024125_1540941.0RepeatANK 3
TgeneMYO16chr18:21819184chr13:109772718ENST00000251041024158_1890941.0RepeatANK 4
TgeneMYO16chr18:21819184chr13:109772718ENST00000251041024191_2170941.0RepeatANK 5
TgeneMYO16chr18:21819184chr13:109772718ENST00000251041024221_2500941.0RepeatANK 6
TgeneMYO16chr18:21819184chr13:109772718ENST00000251041024254_2830941.0RepeatANK 7
TgeneMYO16chr18:21819184chr13:109772718ENST0000025104102459_880941.0RepeatANK 1
TgeneMYO16chr18:21819184chr13:109772718ENST0000025104102492_1210941.0RepeatANK 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000319481-1628877_913481951.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000357041-416430_46399569.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000357041-416877_91399569.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000399443-214430_4630438.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000399443-214877_9130438.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000357041-416235_33499569.0DomainPH
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000399443-214235_3340438.0DomainPH
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000357041-416469_48399569.0MotifFFAT
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000399443-214469_4830438.0MotifFFAT
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000357041-416175_20499569.0RepeatNote=ANK 3
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000357041-41680_10999569.0RepeatNote=ANK 2
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000399443-214175_2040438.0RepeatNote=ANK 3
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000399443-21447_760438.0RepeatNote=ANK 1
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000399443-21480_1090438.0RepeatNote=ANK 2
TgeneMYO16chr18:21819184chr13:109772718ENST000003567112735401_114511241859.0DomainMyosin motor
TgeneMYO16chr18:21819184chr13:109772718ENST000003575502634401_114511241859.0DomainMyosin motor
TgeneMYO16chr18:21819184chr13:109772718ENST000003567112735497_50411241859.0Nucleotide bindingATP
TgeneMYO16chr18:21819184chr13:109772718ENST000003575502634497_50411241859.0Nucleotide bindingATP
TgeneMYO16chr18:21819184chr13:109772718ENST0000035671127351111_137711241859.0RegionInvolved in CYFIP1- and NCKAP1-binding
TgeneMYO16chr18:21819184chr13:109772718ENST0000035755026341111_137711241859.0RegionInvolved in CYFIP1- and NCKAP1-binding
TgeneMYO16chr18:21819184chr13:109772718ENST000003567112735125_15411241859.0RepeatANK 3
TgeneMYO16chr18:21819184chr13:109772718ENST000003567112735158_18911241859.0RepeatANK 4
TgeneMYO16chr18:21819184chr13:109772718ENST000003567112735191_21711241859.0RepeatANK 5
TgeneMYO16chr18:21819184chr13:109772718ENST000003567112735221_25011241859.0RepeatANK 6
TgeneMYO16chr18:21819184chr13:109772718ENST000003567112735254_28311241859.0RepeatANK 7
TgeneMYO16chr18:21819184chr13:109772718ENST00000356711273559_8811241859.0RepeatANK 1
TgeneMYO16chr18:21819184chr13:109772718ENST00000356711273592_12111241859.0RepeatANK 2
TgeneMYO16chr18:21819184chr13:109772718ENST000003575502634125_15411241859.0RepeatANK 3
TgeneMYO16chr18:21819184chr13:109772718ENST000003575502634158_18911241859.0RepeatANK 4
TgeneMYO16chr18:21819184chr13:109772718ENST000003575502634191_21711241859.0RepeatANK 5
TgeneMYO16chr18:21819184chr13:109772718ENST000003575502634221_25011241859.0RepeatANK 6
TgeneMYO16chr18:21819184chr13:109772718ENST000003575502634254_28311241859.0RepeatANK 7
TgeneMYO16chr18:21819184chr13:109772718ENST00000357550263459_8811241859.0RepeatANK 1
TgeneMYO16chr18:21819184chr13:109772718ENST00000357550263492_12111241859.0RepeatANK 2


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Fusion Gene Sequence for OSBPL1A-MYO16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61786_61786_1_OSBPL1A-MYO16_OSBPL1A_chr18_21819184_ENST00000319481_MYO16_chr13_109772718_ENST00000356711_length(transcript)=5027nt_BP=1651nt
CTGCGGGGAGGGGCGGCGCCACCTCGCGCTCCGCCGTGGTCCCGGCGCCGGGTCCCGGAGACAGACGTTACGCGGGCTCGAGCGTCCTCG
GGGAGTGCCAGCCAGAGTTGGTGACGACCACTTCCTCGACGTGGGGCGGGCGGACGGGAAGCCTGGGGTCGTGGCCACCGCCTCGGGAGC
TCTGGGAGCCCGGGTGACCGCGTAGAAATGAACACAGAAGCGGAGCAACAGCTTCTCCATCACGCCAGAAATGGCAATGCTGAAGAAGTA
AGACAACTATTAGAGACCATGGCGAGGAATGAAGTGATTGCTGACATTAATTGCAAAGGAAGAAGTAAGTCTAACTTGGGCTGGACACCT
CTACATCTGGCATGCTATTTTGGACACAGACAAGTGGTCCAGGATCTGTTGAAGGCTGGTGCAGAAGTGAATGTGTTGAATGACATGGGA
GACACGCCGCTTCATCGAGCTGCCTTTACAGGACGAAAGGAGTTGGTAATGCTTCTCTTAGAATATAATGCTGATACTACTATTGTTAAT
GGGAGTGGACAGACAGCAAAAGAAGTTACTCATGCTGAAGAAATCAGAAGCATGCTTGAAGCTGTAGAAAGGACTCAACAAAGAAAGCTT
GAAGAATTACTTTTAGCAGCAGCAAGAGAAGGCAAAACAACAGAACTCACAGCTCTGCTCAACAGGCCCAATCCTCCTGATGTTAACTGT
TCGGATCAGTTAGGAAATACACCCTTGCATTGTGCAGCTTACCGGGCCCATAAACAATGTGCCTTAAAGCTTCTAAGAAGTGGAGCAGAC
CCTAATCTGAAGAACAAAAATGATCAGAAACCTCTTGACCTTGCCCAGGGTGCTGAAATGAAACACATTCTTGTTGGTAATAAGGTCATC
TACAAAGCATTGAAACGATATGAGGGCCCTCTCTGGAAGAGTTCAAGATTTTTTGGCTGGAGATTATTCTGGGTAGTGTTAGAGCATGGA
GTCCTTTCATGGTATAGGAAACAGCCTGATGCAGTTCATAATATTTATCGCCAGGGATGCAAACACCTGACTCAAGCAGTATGCACGGTA
AAATCCACTGATAGCTGCCTCTTCTTTATTAAATGCTTTGATGACACCATTCATGGCTTCCGGGTTCCTAAGAATAGCCTTCAGCAGTCA
AGAGAGGACTGGCTGGAAGCAATAGAAGAACATTCTGCTTACAGCACTCACTACTGTTCCCAGGACCAGCTGACTGATGAGGAGGAGGAA
GATACGGTTTCTGCTGCAGACCTGAAGAAATCATTAGAGAAAGCACAGTCATGCCAACAGCGACTAGATAGGGAAATTTCCAACTTTCTC
AAAATGATTAAGGAGTGTGACATGGCTAAAGAAATGCTTCCATCATTTCTTCAGAAAGTTGAAGTTGTCTCAGAAGCTTCTAGAGAAACT
TGTGTAGCTTTGACTGATTGCCTTAATCTCTTCACCAAACAAGAAGGGGTGAGGAATTTTAAATTGGAACAAGAGCAAGAAAAAAACAAA
ATCTTGTCAGAAGCACTGGAGACGCTGGCCACTGAACATCATGAATTAGAGCAGTCTCTGGTGAAAGGCTCTCCACCCGCCAGCATCCTT
AGCGAGGACGAGTTCTATGATGCGCTGTCAGATGGGAGTCCGAAAAGTGTTTCTAAAATACTGGCATGCTGACCAACTCAATGATTTGTG
CCTACAGTTGCAGAGAAAAATTATAACCTGCCAAAAAGTTATCAGAGGATTTTTAGCACGCCAGCACCTGCTTCAGAGAATAAGCATCAG
ACAACAAGAGGTGACTTCTATCAATAGCTTTCTGCAGAACACAGAGGACATGGGGCTGAAAACCTACGATGCCCTGGTCATTCAGAATGC
TTCAGACATTGCCCGGGAAAATGACCGGCTCCGTAGTGAAATGAACGCTCCCTACCATAAAGAGAAGTTAGAGGTCAGGAACATGCAAGA
GGAAGGAAGCAAAAGAACCGATGACAAGAGTGGACCCAGGCATTTCCACCCCAGCTCCATGTCAGTCTGCGCGGCCGTGGATGGCCTGGG
CCAGTGCCTCGTTGGCCCGTCCATCTGGTCTCCTTCGCTGCACTCGGTGTTCAGCATGGATGACAGCAGCAGCCTCCCGTCTCCACGGAA
ACAGCCCCCGCCCAAGCCAAAGAGGGACCCCAACACCCGGCTGAGTGCTTCCTATGAGGCTGTGAGCGCCTGCCTCTCCGCGGCCAGGGA
AGCGGCCAACGAAGCTCTGGCCCGGCCCAGACCGCACAGCGACGACTACAGCACCATGAAGAAGATTCCTCCTCGAAAGCCCAAGCGCAG
CCCCAACACCAAGCTCAGCGGCTCCTACGAGGAGATATCGGGGTCCCGGCCCGGGGACGCGAGGCCCGCGGGCGCCCCGGGGGCAGCAGC
GCGCGTTCTGACCCCCGGGACTCCGCAGTGCGCGCTGCCCCCGGCGGCGCCTCCGGGTGACGAGGACGACAGCGAGCCTGTGTACATCGA
GATGCTGGGGCACGCGGCCAGGCCCGATAGCCCGGACCCCGGGGAGTCCGTGTACGAGGAGATGAAGTGTTGCCTGCCCGACGACGGCGG
CCCGGGCGCGGGCTCCTTCCTGCTCCACGGCGCATCGCCGCCCCTGCTCCACCGCGCGCCGGAGGACGAGGCGGCGGGGCCCCCAGGGGA
CGCGTGCGACATCCCGCCGCCCTTCCCCAACCTGCTGCCGCACCGGCCGCCCCTGCTGGTGTTCCCCCCGACCCCCGTCACCTGCTCCCC
CGCCTCCGACGAGTCGCCCCTGACACCCCTGGAGGTGAAGAAGCTGCCAGTCCTGGAGACCAACCTCAAGTACCCCGTGCAGCCGGAGGG
GTCGAGCCCGCTGTCCCCGCAGTACTCCAAGAGCCAGAAGGGCGACGGCGACAGGCCCGCGTCCCCCGGCCTGGCGCTGTTCAACGGGTC
CGGCCGAGCCTCCCCGCCGTCCACGCCGCCCCCGCCCCCGCCCCCGCCCGGGCCGCCCCCCGCGCCCTACAGGCCCTGCGCGCACTTGGC
CTTCCCGCCGGAGCCCGCCCCGGTGAACGCGGGGAAAGCGGGGCCGAGCGCAGAGGCGCCCAAGGTTCACCCAAAGCCAAACTCTGCCCC
CGTGGCCGGGCCCTGCAGCTCCTTCCCCAAGATCCCATATTCCCCCGTGAAGGCCACCAGGGCGGACGCCAGGAAGGCCGGCTCCAGTGC
CTCGCCCCCCGCGCCCTACAGCCCTCCCAGCTCCAGGCCTCTCAGCAGCCCCCTGGACGAGCTCGCCAGCCTCTTCAACTCGGGGAGGAG
TGTGCTTCGGAAATCCGCGGCGGGAAGAAAAATCAGGGAAGCAGAAGGTTTTGAAACTAACATGAACATAAGTAGCCGAGATGACCCTAG
TACGTCAGAAATTACTTCCGAGACTCAAGACAGAAATGCAAATAACCATGGAATTCAGTTATCTAATTCACTATCTAGTGCTATAACTGC
TGAAAATGGAAATTCCATCTCAAATGGTTTACCTGAAGAAGATGGATACTCACGGTTGTCTATAAGTGGCACAGGGACTTCGACATTTCA
AAGACACAGGGACAGTCACACCACTCAGGTAATCCATCAGCTGAGGCTCTCAGAGAATGAAAGTGTGGCCCTGCAGGAACTCTTGGACTG
GAGGAGAAAGCTCTGTGAGGAAGGACAAGACTGGCAGCAGATCCTGCACCACGCTGAGCCCAGGGTGCCTCCCCCACCACCTTGCAAGAA
GCCCAGCCTTCTGAAGAAGCCGGAAGGGGCCTCCTGCAACAGGCTGCCGTCTGAGCTCTGGGACACCACCATTTGATGTGGCCTGAACTG
CAGACTTACAAAATAGAACTGCCTACTGATTCCGGGCTGCAACAACAGAAGGCTGCCTTCTGACATGCGCTGGGGCTTCTCTCCACGCAT
TTAGACAAAAAAAGCACAGGACACAGACACTAAATATATGAGATCCCGTGTGTGTGTGTGTGTGTTTGTGTGTGTGTGTGTGGGTTCTTT
CTTATCCATCTCGTGGTGATACACTCTGATTTTCAAGCTCCTCATTTACGGCTCTGTGCTACCCCTAGGTAGCAAGAGAGAGGCTGGGAA
AAGTGTGGACGTGGCCAGAGCGAGAGAGTAGCGGAGGAAAGGAGCAATCCATGCACACTCTGTACAGTTGTTTTTCTACGGTTCAACAGT
CTGTTTATTGTACTTCCAATGGTTTTATTATAATACAGTATACGGGACATATATTTTATTTCTTTGTAGCTACTTGTGTTTTATTGGTAT
TATAAACCTGATAATTATTTACATGTTTATTACTGTAATTTTATAAATTTATGCAATTGGTGGTGCTTCCTTTCTTCAAAATACAGATTT
TAAAAAATCATTTCTAGATTATTTTTTTCCTCCACAGTCCTTTTTTTTCACCTAACGCACCTAAATCTTGAAACTACATTGTTGTTTTAG
CTTCGCCAGTGTCACCCCTTGCAAAACTATGAATTGAGCCCCATGTTTTAGGTGTTACTCATGGATGAGGAGGCTGTTCTTTCCTATGCC
CTGTATTTCTGGATAAGTGGATTGTGTACCCTTTAGTTAAATTTCACCTCCCGACTTCAGCATAGATCACAGGAAATCACATGGCACACG
GTTAAACACGTATGGCTTCAAATCCATAGCCGGTGGTGTAAAATGATCATATTCATTCAAAGGCCTACACAGTACAAATGAGCACGCTGC
CATGTACTGGTTTGAGCAGTAGGGGCTGCATCGCACAGCGCTCGTCCCCCGGGACTTACACTGCATGATTCCCTCACTGTATATCCTCAA
CCCTCCCATAATGCAAGGCCTTGTTCATTGATGTGCTTTCGTCGGCTGTCGGAAAGTTCTGAGCAGTGGCTCCAGACCACCTTGTCTTGC

>61786_61786_1_OSBPL1A-MYO16_OSBPL1A_chr18_21819184_ENST00000319481_MYO16_chr13_109772718_ENST00000356711_length(amino acids)=739AA_BP=5
MMRCQMGVRKVFLKYWHADQLNDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQNTEDMGLKTYDALVIQNASDIAR
ENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSLHSVFSMDDSSSLPSPRKQPPPK
PKRDPNTRLSASYEAVSACLSAAREAANEALARPRPHSDDYSTMKKIPPRKPKRSPNTKLSGSYEEISGSRPGDARPAGAPGAAARVLTP
GTPQCALPPAAPPGDEDDSEPVYIEMLGHAARPDSPDPGESVYEEMKCCLPDDGGPGAGSFLLHGASPPLLHRAPEDEAAGPPGDACDIP
PPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLEVKKLPVLETNLKYPVQPEGSSPLSPQYSKSQKGDGDRPASPGLALFNGSGRASP
PSTPPPPPPPPGPPPAPYRPCAHLAFPPEPAPVNAGKAGPSAEAPKVHPKPNSAPVAGPCSSFPKIPYSPVKATRADARKAGSSASPPAP
YSPPSSRPLSSPLDELASLFNSGRSVLRKSAAGRKIREAEGFETNMNISSRDDPSTSEITSETQDRNANNHGIQLSNSLSSAITAENGNS
ISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQVIHQLRLSENESVALQELLDWRRKLCEEGQDWQQILHHAEPRVPPPPPCKKPSLLK

--------------------------------------------------------------
>61786_61786_2_OSBPL1A-MYO16_OSBPL1A_chr18_21819184_ENST00000357041_MYO16_chr13_109772718_ENST00000356711_length(transcript)=3791nt_BP=415nt
AATGAATGGAGAAGTCTTCTGAAGTGACACCAGTGCCTTATCCCTAGAGGAATATCAGCATAGAAAGCACAGTCATGCCAACAGCGACTA
GATAGGGAAATTTCCAACTTTCTCAAAATGATTAAGGAGTGTGACATGGCTAAAGAAATGCTTCCATCATTTCTTCAGAAAGTTGAAGTT
GTCTCAGAAGCTTCTAGAGAAACTTGTGTAGCTTTGACTGATTGCCTTAATCTCTTCACCAAACAAGAAGGGGTGAGGAATTTTAAATTG
GAACAAGAGCAAGAAAAAAACAAAATCTTGTCAGAAGCACTGGAGACGCTGGCCACTGAACATCATGAATTAGAGCAGTCTCTGGTGAAA
GGCTCTCCACCCGCCAGCATCCTTAGCGAGGACGAGTTCTATGATGCGCTGTCAGATGGGAGTCCGAAAAGTGTTTCTAAAATACTGGCA
TGCTGACCAACTCAATGATTTGTGCCTACAGTTGCAGAGAAAAATTATAACCTGCCAAAAAGTTATCAGAGGATTTTTAGCACGCCAGCA
CCTGCTTCAGAGAATAAGCATCAGACAACAAGAGGTGACTTCTATCAATAGCTTTCTGCAGAACACAGAGGACATGGGGCTGAAAACCTA
CGATGCCCTGGTCATTCAGAATGCTTCAGACATTGCCCGGGAAAATGACCGGCTCCGTAGTGAAATGAACGCTCCCTACCATAAAGAGAA
GTTAGAGGTCAGGAACATGCAAGAGGAAGGAAGCAAAAGAACCGATGACAAGAGTGGACCCAGGCATTTCCACCCCAGCTCCATGTCAGT
CTGCGCGGCCGTGGATGGCCTGGGCCAGTGCCTCGTTGGCCCGTCCATCTGGTCTCCTTCGCTGCACTCGGTGTTCAGCATGGATGACAG
CAGCAGCCTCCCGTCTCCACGGAAACAGCCCCCGCCCAAGCCAAAGAGGGACCCCAACACCCGGCTGAGTGCTTCCTATGAGGCTGTGAG
CGCCTGCCTCTCCGCGGCCAGGGAAGCGGCCAACGAAGCTCTGGCCCGGCCCAGACCGCACAGCGACGACTACAGCACCATGAAGAAGAT
TCCTCCTCGAAAGCCCAAGCGCAGCCCCAACACCAAGCTCAGCGGCTCCTACGAGGAGATATCGGGGTCCCGGCCCGGGGACGCGAGGCC
CGCGGGCGCCCCGGGGGCAGCAGCGCGCGTTCTGACCCCCGGGACTCCGCAGTGCGCGCTGCCCCCGGCGGCGCCTCCGGGTGACGAGGA
CGACAGCGAGCCTGTGTACATCGAGATGCTGGGGCACGCGGCCAGGCCCGATAGCCCGGACCCCGGGGAGTCCGTGTACGAGGAGATGAA
GTGTTGCCTGCCCGACGACGGCGGCCCGGGCGCGGGCTCCTTCCTGCTCCACGGCGCATCGCCGCCCCTGCTCCACCGCGCGCCGGAGGA
CGAGGCGGCGGGGCCCCCAGGGGACGCGTGCGACATCCCGCCGCCCTTCCCCAACCTGCTGCCGCACCGGCCGCCCCTGCTGGTGTTCCC
CCCGACCCCCGTCACCTGCTCCCCCGCCTCCGACGAGTCGCCCCTGACACCCCTGGAGGTGAAGAAGCTGCCAGTCCTGGAGACCAACCT
CAAGTACCCCGTGCAGCCGGAGGGGTCGAGCCCGCTGTCCCCGCAGTACTCCAAGAGCCAGAAGGGCGACGGCGACAGGCCCGCGTCCCC
CGGCCTGGCGCTGTTCAACGGGTCCGGCCGAGCCTCCCCGCCGTCCACGCCGCCCCCGCCCCCGCCCCCGCCCGGGCCGCCCCCCGCGCC
CTACAGGCCCTGCGCGCACTTGGCCTTCCCGCCGGAGCCCGCCCCGGTGAACGCGGGGAAAGCGGGGCCGAGCGCAGAGGCGCCCAAGGT
TCACCCAAAGCCAAACTCTGCCCCCGTGGCCGGGCCCTGCAGCTCCTTCCCCAAGATCCCATATTCCCCCGTGAAGGCCACCAGGGCGGA
CGCCAGGAAGGCCGGCTCCAGTGCCTCGCCCCCCGCGCCCTACAGCCCTCCCAGCTCCAGGCCTCTCAGCAGCCCCCTGGACGAGCTCGC
CAGCCTCTTCAACTCGGGGAGGAGTGTGCTTCGGAAATCCGCGGCGGGAAGAAAAATCAGGGAAGCAGAAGGTTTTGAAACTAACATGAA
CATAAGTAGCCGAGATGACCCTAGTACGTCAGAAATTACTTCCGAGACTCAAGACAGAAATGCAAATAACCATGGAATTCAGTTATCTAA
TTCACTATCTAGTGCTATAACTGCTGAAAATGGAAATTCCATCTCAAATGGTTTACCTGAAGAAGATGGATACTCACGGTTGTCTATAAG
TGGCACAGGGACTTCGACATTTCAAAGACACAGGGACAGTCACACCACTCAGGTAATCCATCAGCTGAGGCTCTCAGAGAATGAAAGTGT
GGCCCTGCAGGAACTCTTGGACTGGAGGAGAAAGCTCTGTGAGGAAGGACAAGACTGGCAGCAGATCCTGCACCACGCTGAGCCCAGGGT
GCCTCCCCCACCACCTTGCAAGAAGCCCAGCCTTCTGAAGAAGCCGGAAGGGGCCTCCTGCAACAGGCTGCCGTCTGAGCTCTGGGACAC
CACCATTTGATGTGGCCTGAACTGCAGACTTACAAAATAGAACTGCCTACTGATTCCGGGCTGCAACAACAGAAGGCTGCCTTCTGACAT
GCGCTGGGGCTTCTCTCCACGCATTTAGACAAAAAAAGCACAGGACACAGACACTAAATATATGAGATCCCGTGTGTGTGTGTGTGTGTT
TGTGTGTGTGTGTGTGGGTTCTTTCTTATCCATCTCGTGGTGATACACTCTGATTTTCAAGCTCCTCATTTACGGCTCTGTGCTACCCCT
AGGTAGCAAGAGAGAGGCTGGGAAAAGTGTGGACGTGGCCAGAGCGAGAGAGTAGCGGAGGAAAGGAGCAATCCATGCACACTCTGTACA
GTTGTTTTTCTACGGTTCAACAGTCTGTTTATTGTACTTCCAATGGTTTTATTATAATACAGTATACGGGACATATATTTTATTTCTTTG
TAGCTACTTGTGTTTTATTGGTATTATAAACCTGATAATTATTTACATGTTTATTACTGTAATTTTATAAATTTATGCAATTGGTGGTGC
TTCCTTTCTTCAAAATACAGATTTTAAAAAATCATTTCTAGATTATTTTTTTCCTCCACAGTCCTTTTTTTTCACCTAACGCACCTAAAT
CTTGAAACTACATTGTTGTTTTAGCTTCGCCAGTGTCACCCCTTGCAAAACTATGAATTGAGCCCCATGTTTTAGGTGTTACTCATGGAT
GAGGAGGCTGTTCTTTCCTATGCCCTGTATTTCTGGATAAGTGGATTGTGTACCCTTTAGTTAAATTTCACCTCCCGACTTCAGCATAGA
TCACAGGAAATCACATGGCACACGGTTAAACACGTATGGCTTCAAATCCATAGCCGGTGGTGTAAAATGATCATATTCATTCAAAGGCCT
ACACAGTACAAATGAGCACGCTGCCATGTACTGGTTTGAGCAGTAGGGGCTGCATCGCACAGCGCTCGTCCCCCGGGACTTACACTGCAT
GATTCCCTCACTGTATATCCTCAACCCTCCCATAATGCAAGGCCTTGTTCATTGATGTGCTTTCGTCGGCTGTCGGAAAGTTCTGAGCAG
TGGCTCCAGACCACCTTGTCTTGCTACTTGGAACTTTTTATTCATACCAGCCTTTGAAAAGTTACTGTGCCAATAAAGAGGTACAACTGT

>61786_61786_2_OSBPL1A-MYO16_OSBPL1A_chr18_21819184_ENST00000357041_MYO16_chr13_109772718_ENST00000356711_length(amino acids)=739AA_BP=5
MMRCQMGVRKVFLKYWHADQLNDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQNTEDMGLKTYDALVIQNASDIAR
ENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSLHSVFSMDDSSSLPSPRKQPPPK
PKRDPNTRLSASYEAVSACLSAAREAANEALARPRPHSDDYSTMKKIPPRKPKRSPNTKLSGSYEEISGSRPGDARPAGAPGAAARVLTP
GTPQCALPPAAPPGDEDDSEPVYIEMLGHAARPDSPDPGESVYEEMKCCLPDDGGPGAGSFLLHGASPPLLHRAPEDEAAGPPGDACDIP
PPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLEVKKLPVLETNLKYPVQPEGSSPLSPQYSKSQKGDGDRPASPGLALFNGSGRASP
PSTPPPPPPPPGPPPAPYRPCAHLAFPPEPAPVNAGKAGPSAEAPKVHPKPNSAPVAGPCSSFPKIPYSPVKATRADARKAGSSASPPAP
YSPPSSRPLSSPLDELASLFNSGRSVLRKSAAGRKIREAEGFETNMNISSRDDPSTSEITSETQDRNANNHGIQLSNSLSSAITAENGNS
ISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQVIHQLRLSENESVALQELLDWRRKLCEEGQDWQQILHHAEPRVPPPPPCKKPSLLK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for OSBPL1A-MYO16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000319481-16281_237481.3333333333333951.0RAB7A


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000357041-4161_23799.33333333333333569.0RAB7A
HgeneOSBPL1Achr18:21819184chr13:109772718ENST00000399443-2141_2370438.0RAB7A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OSBPL1A-MYO16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OSBPL1A-MYO16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource