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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OSBPL1A-ZNF521 (FusionGDB2 ID:61796)

Fusion Gene Summary for OSBPL1A-ZNF521

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL1A-ZNF521
Fusion gene ID: 61796
HgeneTgene
Gene symbol

OSBPL1A

ZNF521

Gene ID

114876

25925

Gene nameoxysterol binding protein like 1Azinc finger protein 521
SynonymsORP-1|ORP1|OSBPL1BEHZF|Evi3
Cytomap

18q11.2

18q11.2

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 1OSBP-related protein 1oxysterol binding protein-like 1Boxysterol-binding protein-related protein 1 variant 1oxysterol-binding protein-related protein 1 variant 2zinc finger protein 521LYST-interacting protein 3early hematopoietic zinc finger protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000319481, ENST00000357041, 
ENST00000399443, ENST00000399441, 
ENST00000582618, 		ENST00000579111, 
ENST00000361524, ENST00000538137, 
ENST00000584787, 
Fusion gene scores* DoF score16 X 16 X 7=179213 X 10 X 9=1170
# samples 1715
** MAII scorelog2(17/1792*10)=-3.3979639859199
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1170*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OSBPL1A [Title/Abstract] AND ZNF521 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOSBPL1A(21805006)-ZNF521(22642705), # samples:3
Anticipated loss of major functional domain due to fusion event.OSBPL1A-ZNF521 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
OSBPL1A-ZNF521 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
OSBPL1A-ZNF521 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across OSBPL1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF521 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-HV-AA8X-01AOSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
ChimerDB4PAADTCGA-HV-AA8XOSBPL1Achr18

21805006

-ZNF521chr18

22642705

-


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Fusion Gene ORF analysis for OSBPL1A-ZNF521

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000319481ENST00000579111OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
5CDS-intronENST00000357041ENST00000579111OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
5CDS-intronENST00000399443ENST00000579111OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
Frame-shiftENST00000319481ENST00000361524OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
Frame-shiftENST00000319481ENST00000538137OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
Frame-shiftENST00000319481ENST00000584787OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
Frame-shiftENST00000357041ENST00000361524OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
Frame-shiftENST00000357041ENST00000538137OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
Frame-shiftENST00000357041ENST00000584787OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
Frame-shiftENST00000399443ENST00000584787OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
In-frameENST00000399443ENST00000361524OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
In-frameENST00000399443ENST00000538137OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
intron-3CDSENST00000399441ENST00000361524OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
intron-3CDSENST00000399441ENST00000538137OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
intron-3CDSENST00000399441ENST00000584787OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
intron-3CDSENST00000582618ENST00000361524OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
intron-3CDSENST00000582618ENST00000538137OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
intron-3CDSENST00000582618ENST00000584787OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
intron-intronENST00000399441ENST00000579111OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-
intron-intronENST00000582618ENST00000579111OSBPL1Achr18

21805006

-ZNF521chr18

22642705

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000399443OSBPL1Achr1821805006-ENST00000361524ZNF521chr1822642705-1747931651142169
ENST00000399443OSBPL1Achr1821805006-ENST00000538137ZNF521chr1822642705-108093164074188

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000399443ENST00000361524OSBPL1Achr1821805006-ZNF521chr1822642705-0.415464520.5845355
ENST00000399443ENST00000538137OSBPL1Achr1821805006-ZNF521chr1822642705-0.497543840.5024561

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Fusion Genomic Features for OSBPL1A-ZNF521


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for OSBPL1A-ZNF521


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:21805006/chr18:22642705)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000319481-1728430_463533951.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000319481-1728235_334533951.0DomainPH
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000319481-1728469_483533951.0MotifFFAT
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000319481-1728175_204533951.0RepeatNote=ANK 3
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000319481-172847_76533951.0RepeatNote=ANK 1
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000319481-172880_109533951.0RepeatNote=ANK 2
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000357041-51647_76151569.0RepeatNote=ANK 1
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000357041-51680_109151569.0RepeatNote=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000319481-1728877_913533951.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000357041-516430_463151569.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000357041-516877_913151569.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000399443-314430_46320438.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000399443-314877_91320438.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000357041-516235_334151569.0DomainPH
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000399443-314235_33420438.0DomainPH
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000357041-516469_483151569.0MotifFFAT
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000399443-314469_48320438.0MotifFFAT
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000357041-516175_204151569.0RepeatNote=ANK 3
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000399443-314175_20420438.0RepeatNote=ANK 3
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000399443-31447_7620438.0RepeatNote=ANK 1
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000399443-31480_10920438.0RepeatNote=ANK 2
TgeneZNF521chr18:21805006chr18:22642705ENST00000361524681020_104213021312.0Zinc fingerC2H2-type 24
TgeneZNF521chr18:21805006chr18:22642705ENST00000361524681065_108313021312.0Zinc fingerC2H2-type 25%3B degenerate
TgeneZNF521chr18:21805006chr18:22642705ENST00000361524681138_116113021312.0Zinc fingerC2H2-type 26
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468118_14013021312.0Zinc fingerC2H2-type 2
TgeneZNF521chr18:21805006chr18:22642705ENST00000361524681195_121713021312.0Zinc fingerC2H2-type 27
TgeneZNF521chr18:21805006chr18:22642705ENST00000361524681225_124713021312.0Zinc fingerC2H2-type 28
TgeneZNF521chr18:21805006chr18:22642705ENST00000361524681256_127913021312.0Zinc fingerC2H2-type 29
TgeneZNF521chr18:21805006chr18:22642705ENST00000361524681286_130913021312.0Zinc fingerC2H2-type 30
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468146_16813021312.0Zinc fingerC2H2-type 3
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468174_19613021312.0Zinc fingerC2H2-type 4
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468202_22413021312.0Zinc fingerC2H2-type 5
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468246_26913021312.0Zinc fingerC2H2-type 6
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468281_30413021312.0Zinc fingerC2H2-type 7
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468310_33213021312.0Zinc fingerC2H2-type 8
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468405_42913021312.0Zinc fingerC2H2-type 9%3B degenerate
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468437_46013021312.0Zinc fingerC2H2-type 10
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468477_50013021312.0Zinc fingerC2H2-type 11
TgeneZNF521chr18:21805006chr18:22642705ENST000003615246847_6713021312.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468513_53613021312.0Zinc fingerC2H2-type 12
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468560_58513021312.0Zinc fingerC2H2-type 13%3B atypical
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468634_65613021312.0Zinc fingerC2H2-type 14
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468664_68613021312.0Zinc fingerC2H2-type 15
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468694_71713021312.0Zinc fingerC2H2-type 16
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468722_74513021312.0Zinc fingerC2H2-type 17
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468752_77513021312.0Zinc fingerC2H2-type 18
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468783_80513021312.0Zinc fingerC2H2-type 19
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468809_83213021312.0Zinc fingerC2H2-type 20
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468886_90813021312.0Zinc fingerC2H2-type 21%3B degenerate
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468930_95213021312.0Zinc fingerC2H2-type 22
TgeneZNF521chr18:21805006chr18:22642705ENST0000036152468959_98113021312.0Zinc fingerC2H2-type 23
TgeneZNF521chr18:21805006chr18:22642705ENST00000538137681020_104213021312.0Zinc fingerC2H2-type 24
TgeneZNF521chr18:21805006chr18:22642705ENST00000538137681065_108313021312.0Zinc fingerC2H2-type 25%3B degenerate
TgeneZNF521chr18:21805006chr18:22642705ENST00000538137681138_116113021312.0Zinc fingerC2H2-type 26
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768118_14013021312.0Zinc fingerC2H2-type 2
TgeneZNF521chr18:21805006chr18:22642705ENST00000538137681195_121713021312.0Zinc fingerC2H2-type 27
TgeneZNF521chr18:21805006chr18:22642705ENST00000538137681225_124713021312.0Zinc fingerC2H2-type 28
TgeneZNF521chr18:21805006chr18:22642705ENST00000538137681256_127913021312.0Zinc fingerC2H2-type 29
TgeneZNF521chr18:21805006chr18:22642705ENST00000538137681286_130913021312.0Zinc fingerC2H2-type 30
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768146_16813021312.0Zinc fingerC2H2-type 3
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768174_19613021312.0Zinc fingerC2H2-type 4
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768202_22413021312.0Zinc fingerC2H2-type 5
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768246_26913021312.0Zinc fingerC2H2-type 6
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768281_30413021312.0Zinc fingerC2H2-type 7
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768310_33213021312.0Zinc fingerC2H2-type 8
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768405_42913021312.0Zinc fingerC2H2-type 9%3B degenerate
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768437_46013021312.0Zinc fingerC2H2-type 10
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768477_50013021312.0Zinc fingerC2H2-type 11
TgeneZNF521chr18:21805006chr18:22642705ENST000005381376847_6713021312.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768513_53613021312.0Zinc fingerC2H2-type 12
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768560_58513021312.0Zinc fingerC2H2-type 13%3B atypical
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768634_65613021312.0Zinc fingerC2H2-type 14
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768664_68613021312.0Zinc fingerC2H2-type 15
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768694_71713021312.0Zinc fingerC2H2-type 16
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768722_74513021312.0Zinc fingerC2H2-type 17
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768752_77513021312.0Zinc fingerC2H2-type 18
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768783_80513021312.0Zinc fingerC2H2-type 19
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768809_83213021312.0Zinc fingerC2H2-type 20
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768886_90813021312.0Zinc fingerC2H2-type 21%3B degenerate
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768930_95213021312.0Zinc fingerC2H2-type 22
TgeneZNF521chr18:21805006chr18:22642705ENST0000053813768959_98113021312.0Zinc fingerC2H2-type 23


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Fusion Gene Sequence for OSBPL1A-ZNF521


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61796_61796_1_OSBPL1A-ZNF521_OSBPL1A_chr18_21805006_ENST00000399443_ZNF521_chr18_22642705_ENST00000361524_length(transcript)=1747nt_BP=931nt
CCAGGGCCGGTGTCTCCAGGAGAGGGCCGAGCGCACAGCAGCTCTAGGACCTCGCAGGCGCCTCGGCGCGGCACTCACGTAGAGCCCAAG
GAGCAGTCCCCGACCTCTCCTCGGAGGGCCGTGCAGGCTTCCCCGGCGGTCCCTACCTGCGCCTCCGCCCGCCAGCGGCGCTGGGGAAGG
GGAGGAGCGGCCCGGACGCTGCCCGCCGCGCGCAGGGAGCCGCCCGCCGCAGGCCTTGCCGCCGCCCGCCCGCGCTCTCCCCGCGAGCCC
CGGAGGGCGGGTCTGCGGCCGAGCCAGCGGCGGCGGAGGGGCAGCGCAGACCTCTGCGGCCCGGGCGGGCGCGGCGCGGGAGTCCTGGGC
CGCTGGCGGGCAACGCCTCTGCCCGACCTCGCTGGGGAAGGCTGGCGCTGCTGCCCGGCCGGAGCCAGGGGCAGGCTGCGCAAAGGTGAC
TTAGGGAGACCTTGCGGGCCGCCCTGGGTCGCGCCTCCCGGATCGGCTCGCCTCGGCTCGACTGGAGGGGAGGAGGAGGAGCAGGCCGAG
CGCATTCGCGCTGGAGCTTGCGAGGAGCGCAGGGTGGAGCGCGCCAGCCGGGGTCCTCGGATCTGGCCCAGGTGAGGAATTTTAAATTGG
AACAAGAGCAAGAAAAAAACAAAATCTTGTCAGAAGCACTGGAGACGCTGGCCACTGAACATCATGAATTAGAGCAGTCTCTGGTGAAAG
GCTCTCCACCCGCCAGCATCCTTAGCGAGGACGAGTTCTATGATGCGCTGTCAGATTCCGAGTCCGAAAGGTCCCTGAGTAGATTGGAAG
CAGTGACAGCACGCTCCTTTGAAGAGGAAGGAGAGCATTTGGGCAGTAGAAAACACAGAATGTCCGAAGAAAAAGACTGTGGTGGCGGAG
ATGCTCTCTCCAATGGCATCAAGAAACACAGAATCATACAATGACCCAACACAGCAGTTAGTGCAAGTACAGTCTCTCAAGGAGAATTGA
TTTTGTGGCACAAAAAGGGAACATGTTTTACTCTTTGCACGAAACTTTCATTGTTAATGTATATTATTCAGAAACATTGTATTGTACCAT
AAAACTTGTATTATCAAACTGTTGGATGTTCATGTGTTTGAACTTTTGCGCACCGGATAGACCCCTTGTATATAAAGTGTTGCACATGTA
TTATGTCGTCTGATACTAAAATGGTCTTATAAAGACAAGTGGACTTGGGCCCTATTCAGGCAAGATTAAAAAAAAAAAAAGACTATGACC
AAAATGGCTTAAGATAAAGTATTTTTAAGGAAGAAAGATTAAAAACAACTGTTATACATGAGACTATGGTTGGACTTCCTTTTCTTTACA
CTTAAGCCTAGAATTTCTCTTTAGGTATATCAGCGCTTAAATCCAAGACTATTTTTTATTGCTGAAGATTCTTGCAAACCATGAAGAGAT
GTTCTCACAGAACAGAACCCCACAGCTGGATAAGGCCCGTATATATATATTTGTAAGCCTTGCAATGTGACAGGTAGCATCACTATATAT
GCAATAGTTGTTATGTAGACTGTCAAAGAATTTTTTTTTCCCTGGATACATTTGAAGCTTTGAGTGTTCAAGGTTTTCCTTAATGATTTC
ACGCAGCCAAATTCTTGAATCAGTTGAACTAACCTGTATGTTACTGTTATTAATGTTTACTCTGCAGTCTGAACCTGGAGATTACTGGAA

>61796_61796_1_OSBPL1A-ZNF521_OSBPL1A_chr18_21805006_ENST00000399443_ZNF521_chr18_22642705_ENST00000361524_length(amino acids)=169AA_BP=
MFFSCSCSNLKFLTWARSEDPGWRAPPCAPRKLQRECARPAPPPPLQSSRGEPIREARPRAARKVSLSHLCAACPWLRPGSSASLPQRGR

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>61796_61796_2_OSBPL1A-ZNF521_OSBPL1A_chr18_21805006_ENST00000399443_ZNF521_chr18_22642705_ENST00000538137_length(transcript)=1080nt_BP=931nt
CCAGGGCCGGTGTCTCCAGGAGAGGGCCGAGCGCACAGCAGCTCTAGGACCTCGCAGGCGCCTCGGCGCGGCACTCACGTAGAGCCCAAG
GAGCAGTCCCCGACCTCTCCTCGGAGGGCCGTGCAGGCTTCCCCGGCGGTCCCTACCTGCGCCTCCGCCCGCCAGCGGCGCTGGGGAAGG
GGAGGAGCGGCCCGGACGCTGCCCGCCGCGCGCAGGGAGCCGCCCGCCGCAGGCCTTGCCGCCGCCCGCCCGCGCTCTCCCCGCGAGCCC
CGGAGGGCGGGTCTGCGGCCGAGCCAGCGGCGGCGGAGGGGCAGCGCAGACCTCTGCGGCCCGGGCGGGCGCGGCGCGGGAGTCCTGGGC
CGCTGGCGGGCAACGCCTCTGCCCGACCTCGCTGGGGAAGGCTGGCGCTGCTGCCCGGCCGGAGCCAGGGGCAGGCTGCGCAAAGGTGAC
TTAGGGAGACCTTGCGGGCCGCCCTGGGTCGCGCCTCCCGGATCGGCTCGCCTCGGCTCGACTGGAGGGGAGGAGGAGGAGCAGGCCGAG
CGCATTCGCGCTGGAGCTTGCGAGGAGCGCAGGGTGGAGCGCGCCAGCCGGGGTCCTCGGATCTGGCCCAGGTGAGGAATTTTAAATTGG
AACAAGAGCAAGAAAAAAACAAAATCTTGTCAGAAGCACTGGAGACGCTGGCCACTGAACATCATGAATTAGAGCAGTCTCTGGTGAAAG
GCTCTCCACCCGCCAGCATCCTTAGCGAGGACGAGTTCTATGATGCGCTGTCAGATTCCGAGTCCGAAAGGTCCCTGAGTAGATTGGAAG
CAGTGACAGCACGCTCCTTTGAAGAGGAAGGAGAGCATTTGGGCAGTAGAAAACACAGAATGTCCGAAGAAAAAGACTGTGGTGGCGGAG
ATGCTCTCTCCAATGGCATCAAGAAACACAGAATCATACAATGACCCAACACAGCAGTTAGTGCAAGTACAGTCTCTCAAGGAGAATTGA
TTTTGTGGCACAAAAAGGGAACATGTTTTACTCTTTGCACGAAACTTTCATTGTTAATGTATATTATTCAGAAACATTGTATTGTACCAT

>61796_61796_2_OSBPL1A-ZNF521_OSBPL1A_chr18_21805006_ENST00000399443_ZNF521_chr18_22642705_ENST00000538137_length(amino acids)=188AA_BP=
MLLFQFKIPHLGQIRGPRLARSTLRSSQAPARMRSACSSSSPPVEPRRADPGGATQGGPQGLPKSPLRSLPLAPAGQQRQPSPARSGRGV
ARQRPRTPAPRPPGPQRSALPLRRRWLGRRPALRGSRGERGRAAARPAAGGSLRAAGSVRAAPPLPQRRWRAEAQVGTAGEACTALRGEV

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Fusion Gene PPI Analysis for OSBPL1A-ZNF521


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000319481-17281_237533.6666666666666951.0RAB7A


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000357041-5161_237151.66666666666666569.0RAB7A
HgeneOSBPL1Achr18:21805006chr18:22642705ENST00000399443-3141_23720.666666666666668438.0RAB7A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OSBPL1A-ZNF521


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OSBPL1A-ZNF521


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource