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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OSBPL9-PICALM (FusionGDB2 ID:61878)

Fusion Gene Summary for OSBPL9-PICALM

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL9-PICALM
Fusion gene ID: 61878
HgeneTgene
Gene symbol

OSBPL9

PICALM

Gene ID

114883

8301

Gene nameoxysterol binding protein like 9phosphatidylinositol binding clathrin assembly protein
SynonymsORP-9|ORP9CALM|CLTH|LAP
Cytomap

1p32.3

11q14.2

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 9OSBP-related protein 9phosphatidylinositol-binding clathrin assembly proteinclathrin assembly lymphoid myeloid leukemia protein
Modification date2020031320200322
UniProtAcc.

Q13492

Ensembl transtripts involved in fusion geneENST00000337809, ENST00000371710, 
ENST00000371714, ENST00000428468, 
ENST00000447887, ENST00000453295, 
ENST00000435686, ENST00000361556, 
ENST00000462759, ENST00000473207, 
ENST00000486942, ENST00000530544, 
ENST00000531828, 		ENST00000356360, 
ENST00000528398, ENST00000528411, 
ENST00000393346, ENST00000526033, 
ENST00000532317, 
Fusion gene scores* DoF score15 X 11 X 8=132035 X 26 X 12=10920
# samples 1544
** MAII scorelog2(15/1320*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(44/10920*10)=-4.63332552228256
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OSBPL9 [Title/Abstract] AND PICALM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOSBPL9(52082893)-PICALM(85742653), # samples:1
Anticipated loss of major functional domain due to fusion event.OSBPL9-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
OSBPL9-PICALM seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
OSBPL9-PICALM seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePICALM

GO:0006897

endocytosis

22118466

TgenePICALM

GO:0006898

receptor-mediated endocytosis

10436022

TgenePICALM

GO:0032880

regulation of protein localization

10436022

TgenePICALM

GO:0045893

positive regulation of transcription, DNA-templated

11425879

TgenePICALM

GO:0048261

negative regulation of receptor-mediated endocytosis

10436022

TgenePICALM

GO:1905224

clathrin-coated pit assembly

16262731


check buttonFusion gene breakpoints across OSBPL9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PICALM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-76-4926-01BOSBPL9chr1

52082893

+PICALMchr11

85742653

-


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Fusion Gene ORF analysis for OSBPL9-PICALM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000337809ENST00000356360OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000337809ENST00000528398OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000337809ENST00000528411OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000371710ENST00000356360OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000371710ENST00000528398OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000371710ENST00000528411OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000371714ENST00000356360OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000371714ENST00000528398OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000371714ENST00000528411OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000428468ENST00000356360OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000428468ENST00000528398OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000428468ENST00000528411OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000447887ENST00000356360OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000447887ENST00000528398OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000447887ENST00000528411OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000453295ENST00000356360OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000453295ENST00000528398OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5CDS-5UTRENST00000453295ENST00000528411OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5UTR-3CDSENST00000435686ENST00000393346OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5UTR-3CDSENST00000435686ENST00000526033OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5UTR-3CDSENST00000435686ENST00000532317OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5UTR-5UTRENST00000435686ENST00000356360OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5UTR-5UTRENST00000435686ENST00000528398OSBPL9chr1

52082893

+PICALMchr11

85742653

-
5UTR-5UTRENST00000435686ENST00000528411OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000337809ENST00000393346OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000337809ENST00000526033OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000337809ENST00000532317OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000371710ENST00000393346OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000371710ENST00000526033OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000371710ENST00000532317OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000371714ENST00000393346OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000371714ENST00000526033OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000371714ENST00000532317OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000428468ENST00000393346OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000428468ENST00000526033OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000428468ENST00000532317OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000447887ENST00000393346OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000447887ENST00000526033OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000447887ENST00000532317OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000453295ENST00000393346OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000453295ENST00000526033OSBPL9chr1

52082893

+PICALMchr11

85742653

-
Frame-shiftENST00000453295ENST00000532317OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000361556ENST00000393346OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000361556ENST00000526033OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000361556ENST00000532317OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000462759ENST00000393346OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000462759ENST00000526033OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000462759ENST00000532317OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000473207ENST00000393346OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000473207ENST00000526033OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000473207ENST00000532317OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000486942ENST00000393346OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000486942ENST00000526033OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000486942ENST00000532317OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000530544ENST00000393346OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000530544ENST00000526033OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000530544ENST00000532317OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000531828ENST00000393346OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000531828ENST00000526033OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-3CDSENST00000531828ENST00000532317OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000361556ENST00000356360OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000361556ENST00000528398OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000361556ENST00000528411OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000462759ENST00000356360OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000462759ENST00000528398OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000462759ENST00000528411OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000473207ENST00000356360OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000473207ENST00000528398OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000473207ENST00000528411OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000486942ENST00000356360OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000486942ENST00000528398OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000486942ENST00000528411OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000530544ENST00000356360OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000530544ENST00000528398OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000530544ENST00000528411OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000531828ENST00000356360OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000531828ENST00000528398OSBPL9chr1

52082893

+PICALMchr11

85742653

-
intron-5UTRENST00000531828ENST00000528411OSBPL9chr1

52082893

+PICALMchr11

85742653

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for OSBPL9-PICALM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for OSBPL9-PICALM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:52082893/:85742653)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PICALM

Q13492

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for OSBPL9-PICALM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for OSBPL9-PICALM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OSBPL9-PICALM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OSBPL9-PICALM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource