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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OSGIN2-RIPK2 (FusionGDB2 ID:61903)

Fusion Gene Summary for OSGIN2-RIPK2

check button Fusion gene summary
Fusion gene informationFusion gene name: OSGIN2-RIPK2
Fusion gene ID: 61903
HgeneTgene
Gene symbol

OSGIN2

RIPK2

Gene ID

734

8767

Gene nameoxidative stress induced growth inhibitor family member 2receptor interacting serine/threonine kinase 2
SynonymsC8orf1|hT41CARD3|CARDIAK|CCK|GIG30|RICK|RIP2
Cytomap

8q21.3

8q21.3

Type of geneprotein-codingprotein-coding
Descriptionoxidative stress-induced growth inhibitor 2receptor-interacting serine/threonine-protein kinase 2CARD-carrying kinaseCARD-containing IL-1 beta ICE-kinaseCARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinaseRIP-2growth-inhibiting gene 30receptor-interacting protein (RIP
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000297438, ENST00000451899, 
ENST00000520659, 		ENST00000540020, 
ENST00000220751, 
Fusion gene scores* DoF score2 X 3 X 5=304 X 6 X 5=120
# samples 66
** MAII scorelog2(6/30*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OSGIN2 [Title/Abstract] AND RIPK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOSGIN2(90926974)-RIPK2(90775057), # samples:3
OSGIN2(90926974)-RIPK2(90798821), # samples:3
Anticipated loss of major functional domain due to fusion event.OSGIN2-RIPK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
OSGIN2-RIPK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
OSGIN2-RIPK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRIPK2

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

21887730

TgeneRIPK2

GO:0010942

positive regulation of cell death

16920334

TgeneRIPK2

GO:0033138

positive regulation of peptidyl-serine phosphorylation

21887730

TgeneRIPK2

GO:0034134

toll-like receptor 2 signaling pathway

11894098

TgeneRIPK2

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

10329646

TgeneRIPK2

GO:0045087

innate immune response

23806334

TgeneRIPK2

GO:0050718

positive regulation of interleukin-1 beta secretion

11432859

TgeneRIPK2

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

21887730

TgeneRIPK2

GO:0051092

positive regulation of NF-kappaB transcription factor activity

11821383

TgeneRIPK2

GO:0070431

nucleotide-binding oligomerization domain containing 2 signaling pathway

23806334

TgeneRIPK2

GO:0071225

cellular response to muramyl dipeptide

21887730

TgeneRIPK2

GO:0097202

activation of cysteine-type endopeptidase activity

11821383


check buttonFusion gene breakpoints across OSGIN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RIPK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OL-A6VO-01AOSGIN2chr8

90926974

-RIPK2chr8

90775057

+
ChimerDB4BRCATCGA-OL-A6VO-01AOSGIN2chr8

90926974

+RIPK2chr8

90775057

+
ChimerDB4HNSCTCGA-CV-5430-01AOSGIN2chr8

90926974

-RIPK2chr8

90798821

+
ChimerDB4HNSCTCGA-CV-5430-01AOSGIN2chr8

90926974

+RIPK2chr8

90798821

+
ChimerDB4HNSCTCGA-CV-5430OSGIN2chr8

90926974

+RIPK2chr8

90798821

+
ChimerDB4LUADTCGA-86-7711-01AOSGIN2chr8

90921949

+RIPK2chr8

90801549

+


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Fusion Gene ORF analysis for OSGIN2-RIPK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000297438ENST00000540020OSGIN2chr8

90926974

+RIPK2chr8

90775057

+
5CDS-intronENST00000451899ENST00000540020OSGIN2chr8

90926974

+RIPK2chr8

90775057

+
5CDS-intronENST00000520659ENST00000540020OSGIN2chr8

90926974

+RIPK2chr8

90775057

+
Frame-shiftENST00000297438ENST00000220751OSGIN2chr8

90926974

+RIPK2chr8

90775057

+
Frame-shiftENST00000451899ENST00000220751OSGIN2chr8

90926974

+RIPK2chr8

90775057

+
Frame-shiftENST00000520659ENST00000220751OSGIN2chr8

90926974

+RIPK2chr8

90775057

+
In-frameENST00000297438ENST00000220751OSGIN2chr8

90926974

+RIPK2chr8

90798821

+
In-frameENST00000297438ENST00000220751OSGIN2chr8

90921949

+RIPK2chr8

90801549

+
In-frameENST00000297438ENST00000540020OSGIN2chr8

90926974

+RIPK2chr8

90798821

+
In-frameENST00000297438ENST00000540020OSGIN2chr8

90921949

+RIPK2chr8

90801549

+
In-frameENST00000451899ENST00000220751OSGIN2chr8

90926974

+RIPK2chr8

90798821

+
In-frameENST00000451899ENST00000220751OSGIN2chr8

90921949

+RIPK2chr8

90801549

+
In-frameENST00000451899ENST00000540020OSGIN2chr8

90926974

+RIPK2chr8

90798821

+
In-frameENST00000451899ENST00000540020OSGIN2chr8

90921949

+RIPK2chr8

90801549

+
In-frameENST00000520659ENST00000220751OSGIN2chr8

90926974

+RIPK2chr8

90798821

+
In-frameENST00000520659ENST00000220751OSGIN2chr8

90921949

+RIPK2chr8

90801549

+
In-frameENST00000520659ENST00000540020OSGIN2chr8

90926974

+RIPK2chr8

90798821

+
In-frameENST00000520659ENST00000540020OSGIN2chr8

90921949

+RIPK2chr8

90801549

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000297438OSGIN2chr890926974+ENST00000220751RIPK2chr890798821+19927513341344336
ENST00000297438OSGIN2chr890926974+ENST00000540020RIPK2chr890798821+13897513341344336
ENST00000451899OSGIN2chr890926974+ENST00000220751RIPK2chr890798821+2029788531381442
ENST00000451899OSGIN2chr890926974+ENST00000540020RIPK2chr890798821+1426788531381442
ENST00000520659OSGIN2chr890926974+ENST00000220751RIPK2chr890798821+1802561331154373
ENST00000520659OSGIN2chr890926974+ENST00000540020RIPK2chr890798821+1199561331154373
ENST00000297438OSGIN2chr890921949+ENST00000220751RIPK2chr890801549+1569422334921195
ENST00000297438OSGIN2chr890921949+ENST00000540020RIPK2chr890801549+966422334921195
ENST00000451899OSGIN2chr890921949+ENST00000220751RIPK2chr890801549+160645953958301
ENST00000451899OSGIN2chr890921949+ENST00000540020RIPK2chr890801549+100345953958301
ENST00000520659OSGIN2chr890921949+ENST00000220751RIPK2chr890801549+137923233731232
ENST00000520659OSGIN2chr890921949+ENST00000540020RIPK2chr890801549+77623233731232

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000297438ENST00000220751OSGIN2chr890926974+RIPK2chr890798821+0.0003516740.99964833
ENST00000297438ENST00000540020OSGIN2chr890926974+RIPK2chr890798821+0.0008486730.99915135
ENST00000451899ENST00000220751OSGIN2chr890926974+RIPK2chr890798821+0.0007557160.99924433
ENST00000451899ENST00000540020OSGIN2chr890926974+RIPK2chr890798821+0.002379430.9976205
ENST00000520659ENST00000220751OSGIN2chr890926974+RIPK2chr890798821+0.0004586580.9995414
ENST00000520659ENST00000540020OSGIN2chr890926974+RIPK2chr890798821+0.0012515840.9987484
ENST00000297438ENST00000220751OSGIN2chr890921949+RIPK2chr890801549+0.0020572330.99794275
ENST00000297438ENST00000540020OSGIN2chr890921949+RIPK2chr890801549+0.004152630.9958474
ENST00000451899ENST00000220751OSGIN2chr890921949+RIPK2chr890801549+0.0007383840.99926156
ENST00000451899ENST00000540020OSGIN2chr890921949+RIPK2chr890801549+0.0037607270.9962393
ENST00000520659ENST00000220751OSGIN2chr890921949+RIPK2chr890801549+0.0004286340.9995714
ENST00000520659ENST00000540020OSGIN2chr890921949+RIPK2chr890801549+0.001644420.99835557

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Fusion Genomic Features for OSGIN2-RIPK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
OSGIN2chr890926974+RIPK2chr890798820+0.0081664390.99183357
OSGIN2chr890926974+RIPK2chr890798820+0.0081664390.99183357
OSGIN2chr890921949+RIPK2chr890801548+0.002597510.9974025
OSGIN2chr890926974+RIPK2chr890775056+0.0003456550.9996543
OSGIN2chr890926974+RIPK2chr890798820+0.0081664390.99183357
OSGIN2chr890926974+RIPK2chr890798820+0.0081664390.99183357
OSGIN2chr890921949+RIPK2chr890801548+0.002597510.9974025
OSGIN2chr890926974+RIPK2chr890775056+0.0003456550.9996543

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for OSGIN2-RIPK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:90926974/chr8:90775057)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRIPK2chr8:90921949chr8:90801549ENST00000220751811432_524374541.0DomainCARD
TgeneRIPK2chr8:90921949chr8:90801549ENST00000540020710432_524237404.0DomainCARD
TgeneRIPK2chr8:90926974chr8:90798821ENST00000220751711432_524343541.0DomainCARD
TgeneRIPK2chr8:90926974chr8:90798821ENST00000540020610432_524206404.0DomainCARD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRIPK2chr8:90921949chr8:90801549ENST0000022075181118_294374541.0DomainProtein kinase
TgeneRIPK2chr8:90921949chr8:90801549ENST0000054002071018_294237404.0DomainProtein kinase
TgeneRIPK2chr8:90926974chr8:90798821ENST0000022075171118_294343541.0DomainProtein kinase
TgeneRIPK2chr8:90926974chr8:90798821ENST0000054002061018_294206404.0DomainProtein kinase
TgeneRIPK2chr8:90921949chr8:90801549ENST0000022075181124_32374541.0Nucleotide bindingATP
TgeneRIPK2chr8:90921949chr8:90801549ENST0000054002071024_32237404.0Nucleotide bindingATP
TgeneRIPK2chr8:90926974chr8:90798821ENST0000022075171124_32343541.0Nucleotide bindingATP
TgeneRIPK2chr8:90926974chr8:90798821ENST0000054002061024_32206404.0Nucleotide bindingATP


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Fusion Gene Sequence for OSGIN2-RIPK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61903_61903_1_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000297438_RIPK2_chr8_90801549_ENST00000220751_length(transcript)=1569nt_BP=422nt
GGTGTGGTCTGGGGCGGGCCTGATGAGCACCTGGATTTTCACCCGGCGTGCTGGTAATTCCTACACTTGTGGGTGTTTGAGAGACATGAA
GAGGGGAGGATGACCTCTTCCCGGAAGCGGGACTTCCATAAAAGAAGCGTGGTGGGCGGGTCCCGGGCACCTGTGGTTTGGTGAGTCCTC
CAGGTAACTGTGATGCGGGGGTCAGCGGGAGAGGCACCCGGAAGCTCCCGGCGTCTGCACCCCGGCAGCGCGAGGAAATGCCCAAAGAAA
CTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACTTTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCC
ATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGGTAATAATAGGAAAAGCTCAAGACTGTTATTTTATGAA
GCTGCATCACTGTCCTGGAAATCACAGTTGGGATAGCACCATTTCTGGATCTCAAAGGGCTGCATTCTGTGATCACAAGACCACTCCATG
CTCTTCAGCAATAATAAATCCACTCTCAACTGCAGGAAACTCAGAACGTCTGCAGCCTGGTATAGCCCAGCAGTGGATCCAGAGCAAAAG
GGAAGACATTGTGAACCAAATGACAGAAGCCTGCCTTAACCAGTCGCTAGATGCCCTTCTGTCCAGGGACTTGATCATGAAAGAGGACTA
TGAACTTGTTAGTACCAAGCCTACAAGGACCTCAAAAGTCAGACAATTACTAGACACTACTGACATCCAAGGAGAAGAATTTGCCAAAGT
TATAGTACAAAAATTGAAAGATAACAAACAAATGGGTCTTCAGCCTTACCCGGAAATACTTGTGGTTTCTAGATCACCATCTTTAAATTT
ACTTCAAAATAAAAGCATGTAAGTGACTGTTTTTCAAGAAGAAATGTGTTTCATAAAAGGATATTTATATCTCTGTTGCTTTGACTTTTT
TTATATAAAATCCGTGAGTATTAAAGCTTTATTGAAGGTTCTTTGGGTAAATATTAGTCTCCCTCCATGACACTGCAGTATTTTTTTTAA
TTAATACAAGTAAAAAGTTTGAATTTTGCTACATAGTTCAATTTTTATGTCTCTTTTGTTAACAGAAACCACTTTTAAAGGATAGTAATT
ATTCTTGTTTATAACAGTGCCTTAAGGTATGATGTATTTCTGATGGAAGCCATTTTCACATTCATGTTCTTCATGGATTATTTGTTACTT
GTCTAAGATGCAATTTGATTTTATGAAGTATATACCCTTTACCCACCAGAGACAGTACAGAATCCCTGCCCTAAAATCCCAGGCTTAATT
GCCCTACAAAGGGTTATTAATTTAAAACTCCATTATTAGGATTACATTTTAAAGTTTTATTTATGAATTCCCTTTAAAAATGATATTTCA
AAGGTAAAACAATACAATATAAAGAAAAAAATAAATATATTAATACCGGCTTCCTGTCCCCATTTTTAACCTCAGCCTTCCCTACTGTCA

>61903_61903_1_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000297438_RIPK2_chr8_90801549_ENST00000220751_length(amino acids)=195AA_BP=29
MGRKVKAMPLVEETSLLEDSSVTFPVVIIGKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGI
AQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILV

--------------------------------------------------------------
>61903_61903_2_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000297438_RIPK2_chr8_90801549_ENST00000540020_length(transcript)=966nt_BP=422nt
GGTGTGGTCTGGGGCGGGCCTGATGAGCACCTGGATTTTCACCCGGCGTGCTGGTAATTCCTACACTTGTGGGTGTTTGAGAGACATGAA
GAGGGGAGGATGACCTCTTCCCGGAAGCGGGACTTCCATAAAAGAAGCGTGGTGGGCGGGTCCCGGGCACCTGTGGTTTGGTGAGTCCTC
CAGGTAACTGTGATGCGGGGGTCAGCGGGAGAGGCACCCGGAAGCTCCCGGCGTCTGCACCCCGGCAGCGCGAGGAAATGCCCAAAGAAA
CTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACTTTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCC
ATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGGTAATAATAGGAAAAGCTCAAGACTGTTATTTTATGAA
GCTGCATCACTGTCCTGGAAATCACAGTTGGGATAGCACCATTTCTGGATCTCAAAGGGCTGCATTCTGTGATCACAAGACCACTCCATG
CTCTTCAGCAATAATAAATCCACTCTCAACTGCAGGAAACTCAGAACGTCTGCAGCCTGGTATAGCCCAGCAGTGGATCCAGAGCAAAAG
GGAAGACATTGTGAACCAAATGACAGAAGCCTGCCTTAACCAGTCGCTAGATGCCCTTCTGTCCAGGGACTTGATCATGAAAGAGGACTA
TGAACTTGTTAGTACCAAGCCTACAAGGACCTCAAAAGTCAGACAATTACTAGACACTACTGACATCCAAGGAGAAGAATTTGCCAAAGT
TATAGTACAAAAATTGAAAGATAACAAACAAATGGGTCTTCAGCCTTACCCGGAAATACTTGTGGTTTCTAGATCACCATCTTTAAATTT

>61903_61903_2_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000297438_RIPK2_chr8_90801549_ENST00000540020_length(amino acids)=195AA_BP=29
MGRKVKAMPLVEETSLLEDSSVTFPVVIIGKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGI
AQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILV

--------------------------------------------------------------
>61903_61903_3_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000451899_RIPK2_chr8_90801549_ENST00000220751_length(transcript)=1606nt_BP=459nt
GCTCCGCCCCTATCGCGGCGCCCCGAGATCACCCGCCTCCGGCGCCTGGCTCCCTGCAGGCGAGGAGCGGAAGCCGCTATCTGGAGGCGG
ACTCCGGCGCCACAGAGCCGGGGCAGCCGCGGCAACGGCGAGGCGCGAGGCAGGGGCGCCCGGCAGACCCCGCGACCCCGAGCCAGCGGG
CGCCCCGAGCGGGCAGCCTCGCCGGGGGAGGCGGAGGCGGCCACGGCGGCCGCGCTCGGGCGCCCCTCGCGCAGCGCTCCATGCCCGTGT
GGTGCTGCCGCTGCTCCCTGGCCGGTCATTTCAGAAACTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACT
TTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCCATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGG
TAATAATAGGAAAAGCTCAAGACTGTTATTTTATGAAGCTGCATCACTGTCCTGGAAATCACAGTTGGGATAGCACCATTTCTGGATCTC
AAAGGGCTGCATTCTGTGATCACAAGACCACTCCATGCTCTTCAGCAATAATAAATCCACTCTCAACTGCAGGAAACTCAGAACGTCTGC
AGCCTGGTATAGCCCAGCAGTGGATCCAGAGCAAAAGGGAAGACATTGTGAACCAAATGACAGAAGCCTGCCTTAACCAGTCGCTAGATG
CCCTTCTGTCCAGGGACTTGATCATGAAAGAGGACTATGAACTTGTTAGTACCAAGCCTACAAGGACCTCAAAAGTCAGACAATTACTAG
ACACTACTGACATCCAAGGAGAAGAATTTGCCAAAGTTATAGTACAAAAATTGAAAGATAACAAACAAATGGGTCTTCAGCCTTACCCGG
AAATACTTGTGGTTTCTAGATCACCATCTTTAAATTTACTTCAAAATAAAAGCATGTAAGTGACTGTTTTTCAAGAAGAAATGTGTTTCA
TAAAAGGATATTTATATCTCTGTTGCTTTGACTTTTTTTATATAAAATCCGTGAGTATTAAAGCTTTATTGAAGGTTCTTTGGGTAAATA
TTAGTCTCCCTCCATGACACTGCAGTATTTTTTTTAATTAATACAAGTAAAAAGTTTGAATTTTGCTACATAGTTCAATTTTTATGTCTC
TTTTGTTAACAGAAACCACTTTTAAAGGATAGTAATTATTCTTGTTTATAACAGTGCCTTAAGGTATGATGTATTTCTGATGGAAGCCAT
TTTCACATTCATGTTCTTCATGGATTATTTGTTACTTGTCTAAGATGCAATTTGATTTTATGAAGTATATACCCTTTACCCACCAGAGAC
AGTACAGAATCCCTGCCCTAAAATCCCAGGCTTAATTGCCCTACAAAGGGTTATTAATTTAAAACTCCATTATTAGGATTACATTTTAAA
GTTTTATTTATGAATTCCCTTTAAAAATGATATTTCAAAGGTAAAACAATACAATATAAAGAAAAAAATAAATATATTAATACCGGCTTC

>61903_61903_3_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000451899_RIPK2_chr8_90801549_ENST00000220751_length(amino acids)=301AA_BP=135
MQARSGSRYLEADSGATEPGQPRQRRGARQGRPADPATPSQRAPRAGSLAGGGGGGHGGRARAPLAQRSMPVWCCRCSLAGHFRNYSDTE
TEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAII
NPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKL

--------------------------------------------------------------
>61903_61903_4_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000451899_RIPK2_chr8_90801549_ENST00000540020_length(transcript)=1003nt_BP=459nt
GCTCCGCCCCTATCGCGGCGCCCCGAGATCACCCGCCTCCGGCGCCTGGCTCCCTGCAGGCGAGGAGCGGAAGCCGCTATCTGGAGGCGG
ACTCCGGCGCCACAGAGCCGGGGCAGCCGCGGCAACGGCGAGGCGCGAGGCAGGGGCGCCCGGCAGACCCCGCGACCCCGAGCCAGCGGG
CGCCCCGAGCGGGCAGCCTCGCCGGGGGAGGCGGAGGCGGCCACGGCGGCCGCGCTCGGGCGCCCCTCGCGCAGCGCTCCATGCCCGTGT
GGTGCTGCCGCTGCTCCCTGGCCGGTCATTTCAGAAACTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACT
TTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCCATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGG
TAATAATAGGAAAAGCTCAAGACTGTTATTTTATGAAGCTGCATCACTGTCCTGGAAATCACAGTTGGGATAGCACCATTTCTGGATCTC
AAAGGGCTGCATTCTGTGATCACAAGACCACTCCATGCTCTTCAGCAATAATAAATCCACTCTCAACTGCAGGAAACTCAGAACGTCTGC
AGCCTGGTATAGCCCAGCAGTGGATCCAGAGCAAAAGGGAAGACATTGTGAACCAAATGACAGAAGCCTGCCTTAACCAGTCGCTAGATG
CCCTTCTGTCCAGGGACTTGATCATGAAAGAGGACTATGAACTTGTTAGTACCAAGCCTACAAGGACCTCAAAAGTCAGACAATTACTAG
ACACTACTGACATCCAAGGAGAAGAATTTGCCAAAGTTATAGTACAAAAATTGAAAGATAACAAACAAATGGGTCTTCAGCCTTACCCGG
AAATACTTGTGGTTTCTAGATCACCATCTTTAAATTTACTTCAAAATAAAAGCATGTAAGTGACTGTTTTTCAAGAAGAAATGTGTTTCA

>61903_61903_4_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000451899_RIPK2_chr8_90801549_ENST00000540020_length(amino acids)=301AA_BP=135
MQARSGSRYLEADSGATEPGQPRQRRGARQGRPADPATPSQRAPRAGSLAGGGGGGHGGRARAPLAQRSMPVWCCRCSLAGHFRNYSDTE
TEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAII
NPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKL

--------------------------------------------------------------
>61903_61903_5_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000520659_RIPK2_chr8_90801549_ENST00000220751_length(transcript)=1379nt_BP=232nt
GGCCGCGCTCGGGCGCCCCTCGCGCAGCGCTCCATGCCCGTGTGGTGCTGCCGCTGCTCCCTGGCCGGTCATTTCAGAAACTATAGTGAC
ACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACTTTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCCATTAGTTGAA
GAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGGTAATAATAGGAAAAGCTCAAGACTGTTATTTTATGAAGCTGCATCAC
TGTCCTGGAAATCACAGTTGGGATAGCACCATTTCTGGATCTCAAAGGGCTGCATTCTGTGATCACAAGACCACTCCATGCTCTTCAGCA
ATAATAAATCCACTCTCAACTGCAGGAAACTCAGAACGTCTGCAGCCTGGTATAGCCCAGCAGTGGATCCAGAGCAAAAGGGAAGACATT
GTGAACCAAATGACAGAAGCCTGCCTTAACCAGTCGCTAGATGCCCTTCTGTCCAGGGACTTGATCATGAAAGAGGACTATGAACTTGTT
AGTACCAAGCCTACAAGGACCTCAAAAGTCAGACAATTACTAGACACTACTGACATCCAAGGAGAAGAATTTGCCAAAGTTATAGTACAA
AAATTGAAAGATAACAAACAAATGGGTCTTCAGCCTTACCCGGAAATACTTGTGGTTTCTAGATCACCATCTTTAAATTTACTTCAAAAT
AAAAGCATGTAAGTGACTGTTTTTCAAGAAGAAATGTGTTTCATAAAAGGATATTTATATCTCTGTTGCTTTGACTTTTTTTATATAAAA
TCCGTGAGTATTAAAGCTTTATTGAAGGTTCTTTGGGTAAATATTAGTCTCCCTCCATGACACTGCAGTATTTTTTTTAATTAATACAAG
TAAAAAGTTTGAATTTTGCTACATAGTTCAATTTTTATGTCTCTTTTGTTAACAGAAACCACTTTTAAAGGATAGTAATTATTCTTGTTT
ATAACAGTGCCTTAAGGTATGATGTATTTCTGATGGAAGCCATTTTCACATTCATGTTCTTCATGGATTATTTGTTACTTGTCTAAGATG
CAATTTGATTTTATGAAGTATATACCCTTTACCCACCAGAGACAGTACAGAATCCCTGCCCTAAAATCCCAGGCTTAATTGCCCTACAAA
GGGTTATTAATTTAAAACTCCATTATTAGGATTACATTTTAAAGTTTTATTTATGAATTCCCTTTAAAAATGATATTTCAAAGGTAAAAC
AATACAATATAAAGAAAAAAATAAATATATTAATACCGGCTTCCTGTCCCCATTTTTAACCTCAGCCTTCCCTACTGTCACCAACAACCA

>61903_61903_5_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000520659_RIPK2_chr8_90801549_ENST00000220751_length(amino acids)=232AA_BP=66
MPVWCCRCSLAGHFRNYSDTETEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGKAQDCYFMKLHHCPGNHSWDSTI
SGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVR

--------------------------------------------------------------
>61903_61903_6_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000520659_RIPK2_chr8_90801549_ENST00000540020_length(transcript)=776nt_BP=232nt
GGCCGCGCTCGGGCGCCCCTCGCGCAGCGCTCCATGCCCGTGTGGTGCTGCCGCTGCTCCCTGGCCGGTCATTTCAGAAACTATAGTGAC
ACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACTTTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCCATTAGTTGAA
GAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGGTAATAATAGGAAAAGCTCAAGACTGTTATTTTATGAAGCTGCATCAC
TGTCCTGGAAATCACAGTTGGGATAGCACCATTTCTGGATCTCAAAGGGCTGCATTCTGTGATCACAAGACCACTCCATGCTCTTCAGCA
ATAATAAATCCACTCTCAACTGCAGGAAACTCAGAACGTCTGCAGCCTGGTATAGCCCAGCAGTGGATCCAGAGCAAAAGGGAAGACATT
GTGAACCAAATGACAGAAGCCTGCCTTAACCAGTCGCTAGATGCCCTTCTGTCCAGGGACTTGATCATGAAAGAGGACTATGAACTTGTT
AGTACCAAGCCTACAAGGACCTCAAAAGTCAGACAATTACTAGACACTACTGACATCCAAGGAGAAGAATTTGCCAAAGTTATAGTACAA
AAATTGAAAGATAACAAACAAATGGGTCTTCAGCCTTACCCGGAAATACTTGTGGTTTCTAGATCACCATCTTTAAATTTACTTCAAAAT

>61903_61903_6_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000520659_RIPK2_chr8_90801549_ENST00000540020_length(amino acids)=232AA_BP=66
MPVWCCRCSLAGHFRNYSDTETEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGKAQDCYFMKLHHCPGNHSWDSTI
SGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVR

--------------------------------------------------------------
>61903_61903_7_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000297438_RIPK2_chr8_90798821_ENST00000220751_length(transcript)=1992nt_BP=751nt
GGTGTGGTCTGGGGCGGGCCTGATGAGCACCTGGATTTTCACCCGGCGTGCTGGTAATTCCTACACTTGTGGGTGTTTGAGAGACATGAA
GAGGGGAGGATGACCTCTTCCCGGAAGCGGGACTTCCATAAAAGAAGCGTGGTGGGCGGGTCCCGGGCACCTGTGGTTTGGTGAGTCCTC
CAGGTAACTGTGATGCGGGGGTCAGCGGGAGAGGCACCCGGAAGCTCCCGGCGTCTGCACCCCGGCAGCGCGAGGAAATGCCCAAAGAAA
CTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACTTTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCC
ATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGGTAATAATAGGAAATGGACCCTCAGGAATATGCCTTTC
TTATATGTTATCAGGCTACAGACCGTATTTATCATCAGAAGCAATACACCCAAATACAATCTTAAATAGTAAATTAGAAGAAGCAAGACA
TCTTTCCATTGTTGATCAGGACTTAGAATACTTGTCTGAGGGCCTTGAGGGCCGATCATCCAATCCAGTTGCAGTACTTTTCGATACACT
TCTTCATCCAGATGCTGACTTTGGGTATGATTATCCATCCGTTTTGCATTGGAAATTAGAGCAACATCATTATATCCCTCACGTAGTTCT
TGGTAAAGGTCCACCTGGTGGGGCTTGGCATGAATCATGTGGATCCTCTCAGCTCCATGAAAATAGTGGTTCTCCTGAAACTTCAAGGTC
CCTGCCAGCTCCTCAAGACAATGATTTTTTATCTAGAAAAGCTCAAGACTGTTATTTTATGAAGCTGCATCACTGTCCTGGAAATCACAG
TTGGGATAGCACCATTTCTGGATCTCAAAGGGCTGCATTCTGTGATCACAAGACCACTCCATGCTCTTCAGCAATAATAAATCCACTCTC
AACTGCAGGAAACTCAGAACGTCTGCAGCCTGGTATAGCCCAGCAGTGGATCCAGAGCAAAAGGGAAGACATTGTGAACCAAATGACAGA
AGCCTGCCTTAACCAGTCGCTAGATGCCCTTCTGTCCAGGGACTTGATCATGAAAGAGGACTATGAACTTGTTAGTACCAAGCCTACAAG
GACCTCAAAAGTCAGACAATTACTAGACACTACTGACATCCAAGGAGAAGAATTTGCCAAAGTTATAGTACAAAAATTGAAAGATAACAA
ACAAATGGGTCTTCAGCCTTACCCGGAAATACTTGTGGTTTCTAGATCACCATCTTTAAATTTACTTCAAAATAAAAGCATGTAAGTGAC
TGTTTTTCAAGAAGAAATGTGTTTCATAAAAGGATATTTATATCTCTGTTGCTTTGACTTTTTTTATATAAAATCCGTGAGTATTAAAGC
TTTATTGAAGGTTCTTTGGGTAAATATTAGTCTCCCTCCATGACACTGCAGTATTTTTTTTAATTAATACAAGTAAAAAGTTTGAATTTT
GCTACATAGTTCAATTTTTATGTCTCTTTTGTTAACAGAAACCACTTTTAAAGGATAGTAATTATTCTTGTTTATAACAGTGCCTTAAGG
TATGATGTATTTCTGATGGAAGCCATTTTCACATTCATGTTCTTCATGGATTATTTGTTACTTGTCTAAGATGCAATTTGATTTTATGAA
GTATATACCCTTTACCCACCAGAGACAGTACAGAATCCCTGCCCTAAAATCCCAGGCTTAATTGCCCTACAAAGGGTTATTAATTTAAAA
CTCCATTATTAGGATTACATTTTAAAGTTTTATTTATGAATTCCCTTTAAAAATGATATTTCAAAGGTAAAACAATACAATATAAAGAAA
AAAATAAATATATTAATACCGGCTTCCTGTCCCCATTTTTAACCTCAGCCTTCCCTACTGTCACCAACAACCAAGCTAAATAAAGTCAAC

>61903_61903_7_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000297438_RIPK2_chr8_90798821_ENST00000220751_length(amino acids)=336AA_BP=139
MGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEAIHPNTILNSKLEEARHLSIVDQDLEYLSEGLEGRSSN
PVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMK
LHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDY

--------------------------------------------------------------
>61903_61903_8_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000297438_RIPK2_chr8_90798821_ENST00000540020_length(transcript)=1389nt_BP=751nt
GGTGTGGTCTGGGGCGGGCCTGATGAGCACCTGGATTTTCACCCGGCGTGCTGGTAATTCCTACACTTGTGGGTGTTTGAGAGACATGAA
GAGGGGAGGATGACCTCTTCCCGGAAGCGGGACTTCCATAAAAGAAGCGTGGTGGGCGGGTCCCGGGCACCTGTGGTTTGGTGAGTCCTC
CAGGTAACTGTGATGCGGGGGTCAGCGGGAGAGGCACCCGGAAGCTCCCGGCGTCTGCACCCCGGCAGCGCGAGGAAATGCCCAAAGAAA
CTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACTTTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCC
ATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGGTAATAATAGGAAATGGACCCTCAGGAATATGCCTTTC
TTATATGTTATCAGGCTACAGACCGTATTTATCATCAGAAGCAATACACCCAAATACAATCTTAAATAGTAAATTAGAAGAAGCAAGACA
TCTTTCCATTGTTGATCAGGACTTAGAATACTTGTCTGAGGGCCTTGAGGGCCGATCATCCAATCCAGTTGCAGTACTTTTCGATACACT
TCTTCATCCAGATGCTGACTTTGGGTATGATTATCCATCCGTTTTGCATTGGAAATTAGAGCAACATCATTATATCCCTCACGTAGTTCT
TGGTAAAGGTCCACCTGGTGGGGCTTGGCATGAATCATGTGGATCCTCTCAGCTCCATGAAAATAGTGGTTCTCCTGAAACTTCAAGGTC
CCTGCCAGCTCCTCAAGACAATGATTTTTTATCTAGAAAAGCTCAAGACTGTTATTTTATGAAGCTGCATCACTGTCCTGGAAATCACAG
TTGGGATAGCACCATTTCTGGATCTCAAAGGGCTGCATTCTGTGATCACAAGACCACTCCATGCTCTTCAGCAATAATAAATCCACTCTC
AACTGCAGGAAACTCAGAACGTCTGCAGCCTGGTATAGCCCAGCAGTGGATCCAGAGCAAAAGGGAAGACATTGTGAACCAAATGACAGA
AGCCTGCCTTAACCAGTCGCTAGATGCCCTTCTGTCCAGGGACTTGATCATGAAAGAGGACTATGAACTTGTTAGTACCAAGCCTACAAG
GACCTCAAAAGTCAGACAATTACTAGACACTACTGACATCCAAGGAGAAGAATTTGCCAAAGTTATAGTACAAAAATTGAAAGATAACAA
ACAAATGGGTCTTCAGCCTTACCCGGAAATACTTGTGGTTTCTAGATCACCATCTTTAAATTTACTTCAAAATAAAAGCATGTAAGTGAC

>61903_61903_8_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000297438_RIPK2_chr8_90798821_ENST00000540020_length(amino acids)=336AA_BP=139
MGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEAIHPNTILNSKLEEARHLSIVDQDLEYLSEGLEGRSSN
PVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMK
LHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDY

--------------------------------------------------------------
>61903_61903_9_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000451899_RIPK2_chr8_90798821_ENST00000220751_length(transcript)=2029nt_BP=788nt
GCTCCGCCCCTATCGCGGCGCCCCGAGATCACCCGCCTCCGGCGCCTGGCTCCCTGCAGGCGAGGAGCGGAAGCCGCTATCTGGAGGCGG
ACTCCGGCGCCACAGAGCCGGGGCAGCCGCGGCAACGGCGAGGCGCGAGGCAGGGGCGCCCGGCAGACCCCGCGACCCCGAGCCAGCGGG
CGCCCCGAGCGGGCAGCCTCGCCGGGGGAGGCGGAGGCGGCCACGGCGGCCGCGCTCGGGCGCCCCTCGCGCAGCGCTCCATGCCCGTGT
GGTGCTGCCGCTGCTCCCTGGCCGGTCATTTCAGAAACTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACT
TTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCCATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGG
TAATAATAGGAAATGGACCCTCAGGAATATGCCTTTCTTATATGTTATCAGGCTACAGACCGTATTTATCATCAGAAGCAATACACCCAA
ATACAATCTTAAATAGTAAATTAGAAGAAGCAAGACATCTTTCCATTGTTGATCAGGACTTAGAATACTTGTCTGAGGGCCTTGAGGGCC
GATCATCCAATCCAGTTGCAGTACTTTTCGATACACTTCTTCATCCAGATGCTGACTTTGGGTATGATTATCCATCCGTTTTGCATTGGA
AATTAGAGCAACATCATTATATCCCTCACGTAGTTCTTGGTAAAGGTCCACCTGGTGGGGCTTGGCATGAATCATGTGGATCCTCTCAGC
TCCATGAAAATAGTGGTTCTCCTGAAACTTCAAGGTCCCTGCCAGCTCCTCAAGACAATGATTTTTTATCTAGAAAAGCTCAAGACTGTT
ATTTTATGAAGCTGCATCACTGTCCTGGAAATCACAGTTGGGATAGCACCATTTCTGGATCTCAAAGGGCTGCATTCTGTGATCACAAGA
CCACTCCATGCTCTTCAGCAATAATAAATCCACTCTCAACTGCAGGAAACTCAGAACGTCTGCAGCCTGGTATAGCCCAGCAGTGGATCC
AGAGCAAAAGGGAAGACATTGTGAACCAAATGACAGAAGCCTGCCTTAACCAGTCGCTAGATGCCCTTCTGTCCAGGGACTTGATCATGA
AAGAGGACTATGAACTTGTTAGTACCAAGCCTACAAGGACCTCAAAAGTCAGACAATTACTAGACACTACTGACATCCAAGGAGAAGAAT
TTGCCAAAGTTATAGTACAAAAATTGAAAGATAACAAACAAATGGGTCTTCAGCCTTACCCGGAAATACTTGTGGTTTCTAGATCACCAT
CTTTAAATTTACTTCAAAATAAAAGCATGTAAGTGACTGTTTTTCAAGAAGAAATGTGTTTCATAAAAGGATATTTATATCTCTGTTGCT
TTGACTTTTTTTATATAAAATCCGTGAGTATTAAAGCTTTATTGAAGGTTCTTTGGGTAAATATTAGTCTCCCTCCATGACACTGCAGTA
TTTTTTTTAATTAATACAAGTAAAAAGTTTGAATTTTGCTACATAGTTCAATTTTTATGTCTCTTTTGTTAACAGAAACCACTTTTAAAG
GATAGTAATTATTCTTGTTTATAACAGTGCCTTAAGGTATGATGTATTTCTGATGGAAGCCATTTTCACATTCATGTTCTTCATGGATTA
TTTGTTACTTGTCTAAGATGCAATTTGATTTTATGAAGTATATACCCTTTACCCACCAGAGACAGTACAGAATCCCTGCCCTAAAATCCC
AGGCTTAATTGCCCTACAAAGGGTTATTAATTTAAAACTCCATTATTAGGATTACATTTTAAAGTTTTATTTATGAATTCCCTTTAAAAA
TGATATTTCAAAGGTAAAACAATACAATATAAAGAAAAAAATAAATATATTAATACCGGCTTCCTGTCCCCATTTTTAACCTCAGCCTTC

>61903_61903_9_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000451899_RIPK2_chr8_90798821_ENST00000220751_length(amino acids)=442AA_BP=245
MQARSGSRYLEADSGATEPGQPRQRRGARQGRPADPATPSQRAPRAGSLAGGGGGGHGGRARAPLAQRSMPVWCCRCSLAGHFRNYSDTE
TEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEAIHPNTILNSKLEEARHLSIVD
QDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHESCGSSQLHENSGSPETSRSLPAPQ
DNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQ

--------------------------------------------------------------
>61903_61903_10_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000451899_RIPK2_chr8_90798821_ENST00000540020_length(transcript)=1426nt_BP=788nt
GCTCCGCCCCTATCGCGGCGCCCCGAGATCACCCGCCTCCGGCGCCTGGCTCCCTGCAGGCGAGGAGCGGAAGCCGCTATCTGGAGGCGG
ACTCCGGCGCCACAGAGCCGGGGCAGCCGCGGCAACGGCGAGGCGCGAGGCAGGGGCGCCCGGCAGACCCCGCGACCCCGAGCCAGCGGG
CGCCCCGAGCGGGCAGCCTCGCCGGGGGAGGCGGAGGCGGCCACGGCGGCCGCGCTCGGGCGCCCCTCGCGCAGCGCTCCATGCCCGTGT
GGTGCTGCCGCTGCTCCCTGGCCGGTCATTTCAGAAACTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACT
TTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCCATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGG
TAATAATAGGAAATGGACCCTCAGGAATATGCCTTTCTTATATGTTATCAGGCTACAGACCGTATTTATCATCAGAAGCAATACACCCAA
ATACAATCTTAAATAGTAAATTAGAAGAAGCAAGACATCTTTCCATTGTTGATCAGGACTTAGAATACTTGTCTGAGGGCCTTGAGGGCC
GATCATCCAATCCAGTTGCAGTACTTTTCGATACACTTCTTCATCCAGATGCTGACTTTGGGTATGATTATCCATCCGTTTTGCATTGGA
AATTAGAGCAACATCATTATATCCCTCACGTAGTTCTTGGTAAAGGTCCACCTGGTGGGGCTTGGCATGAATCATGTGGATCCTCTCAGC
TCCATGAAAATAGTGGTTCTCCTGAAACTTCAAGGTCCCTGCCAGCTCCTCAAGACAATGATTTTTTATCTAGAAAAGCTCAAGACTGTT
ATTTTATGAAGCTGCATCACTGTCCTGGAAATCACAGTTGGGATAGCACCATTTCTGGATCTCAAAGGGCTGCATTCTGTGATCACAAGA
CCACTCCATGCTCTTCAGCAATAATAAATCCACTCTCAACTGCAGGAAACTCAGAACGTCTGCAGCCTGGTATAGCCCAGCAGTGGATCC
AGAGCAAAAGGGAAGACATTGTGAACCAAATGACAGAAGCCTGCCTTAACCAGTCGCTAGATGCCCTTCTGTCCAGGGACTTGATCATGA
AAGAGGACTATGAACTTGTTAGTACCAAGCCTACAAGGACCTCAAAAGTCAGACAATTACTAGACACTACTGACATCCAAGGAGAAGAAT
TTGCCAAAGTTATAGTACAAAAATTGAAAGATAACAAACAAATGGGTCTTCAGCCTTACCCGGAAATACTTGTGGTTTCTAGATCACCAT

>61903_61903_10_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000451899_RIPK2_chr8_90798821_ENST00000540020_length(amino acids)=442AA_BP=245
MQARSGSRYLEADSGATEPGQPRQRRGARQGRPADPATPSQRAPRAGSLAGGGGGGHGGRARAPLAQRSMPVWCCRCSLAGHFRNYSDTE
TEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEAIHPNTILNSKLEEARHLSIVD
QDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHESCGSSQLHENSGSPETSRSLPAPQ
DNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQ

--------------------------------------------------------------
>61903_61903_11_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000520659_RIPK2_chr8_90798821_ENST00000220751_length(transcript)=1802nt_BP=561nt
GGCCGCGCTCGGGCGCCCCTCGCGCAGCGCTCCATGCCCGTGTGGTGCTGCCGCTGCTCCCTGGCCGGTCATTTCAGAAACTATAGTGAC
ACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACTTTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCCATTAGTTGAA
GAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGGTAATAATAGGAAATGGACCCTCAGGAATATGCCTTTCTTATATGTTA
TCAGGCTACAGACCGTATTTATCATCAGAAGCAATACACCCAAATACAATCTTAAATAGTAAATTAGAAGAAGCAAGACATCTTTCCATT
GTTGATCAGGACTTAGAATACTTGTCTGAGGGCCTTGAGGGCCGATCATCCAATCCAGTTGCAGTACTTTTCGATACACTTCTTCATCCA
GATGCTGACTTTGGGTATGATTATCCATCCGTTTTGCATTGGAAATTAGAGCAACATCATTATATCCCTCACGTAGTTCTTGGTAAAGGT
CCACCTGGTGGGGCTTGGCATGAATCATGTGGATCCTCTCAGCTCCATGAAAATAGTGGTTCTCCTGAAACTTCAAGGTCCCTGCCAGCT
CCTCAAGACAATGATTTTTTATCTAGAAAAGCTCAAGACTGTTATTTTATGAAGCTGCATCACTGTCCTGGAAATCACAGTTGGGATAGC
ACCATTTCTGGATCTCAAAGGGCTGCATTCTGTGATCACAAGACCACTCCATGCTCTTCAGCAATAATAAATCCACTCTCAACTGCAGGA
AACTCAGAACGTCTGCAGCCTGGTATAGCCCAGCAGTGGATCCAGAGCAAAAGGGAAGACATTGTGAACCAAATGACAGAAGCCTGCCTT
AACCAGTCGCTAGATGCCCTTCTGTCCAGGGACTTGATCATGAAAGAGGACTATGAACTTGTTAGTACCAAGCCTACAAGGACCTCAAAA
GTCAGACAATTACTAGACACTACTGACATCCAAGGAGAAGAATTTGCCAAAGTTATAGTACAAAAATTGAAAGATAACAAACAAATGGGT
CTTCAGCCTTACCCGGAAATACTTGTGGTTTCTAGATCACCATCTTTAAATTTACTTCAAAATAAAAGCATGTAAGTGACTGTTTTTCAA
GAAGAAATGTGTTTCATAAAAGGATATTTATATCTCTGTTGCTTTGACTTTTTTTATATAAAATCCGTGAGTATTAAAGCTTTATTGAAG
GTTCTTTGGGTAAATATTAGTCTCCCTCCATGACACTGCAGTATTTTTTTTAATTAATACAAGTAAAAAGTTTGAATTTTGCTACATAGT
TCAATTTTTATGTCTCTTTTGTTAACAGAAACCACTTTTAAAGGATAGTAATTATTCTTGTTTATAACAGTGCCTTAAGGTATGATGTAT
TTCTGATGGAAGCCATTTTCACATTCATGTTCTTCATGGATTATTTGTTACTTGTCTAAGATGCAATTTGATTTTATGAAGTATATACCC
TTTACCCACCAGAGACAGTACAGAATCCCTGCCCTAAAATCCCAGGCTTAATTGCCCTACAAAGGGTTATTAATTTAAAACTCCATTATT
AGGATTACATTTTAAAGTTTTATTTATGAATTCCCTTTAAAAATGATATTTCAAAGGTAAAACAATACAATATAAAGAAAAAAATAAATA
TATTAATACCGGCTTCCTGTCCCCATTTTTAACCTCAGCCTTCCCTACTGTCACCAACAACCAAGCTAAATAAAGTCAACAGCCTGATGT

>61903_61903_11_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000520659_RIPK2_chr8_90798821_ENST00000220751_length(amino acids)=373AA_BP=176
MPVWCCRCSLAGHFRNYSDTETEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEA
IHPNTILNSKLEEARHLSIVDQDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHESCG
SSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQ
QWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVS

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>61903_61903_12_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000520659_RIPK2_chr8_90798821_ENST00000540020_length(transcript)=1199nt_BP=561nt
GGCCGCGCTCGGGCGCCCCTCGCGCAGCGCTCCATGCCCGTGTGGTGCTGCCGCTGCTCCCTGGCCGGTCATTTCAGAAACTATAGTGAC
ACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACTTTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCCATTAGTTGAA
GAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGGTAATAATAGGAAATGGACCCTCAGGAATATGCCTTTCTTATATGTTA
TCAGGCTACAGACCGTATTTATCATCAGAAGCAATACACCCAAATACAATCTTAAATAGTAAATTAGAAGAAGCAAGACATCTTTCCATT
GTTGATCAGGACTTAGAATACTTGTCTGAGGGCCTTGAGGGCCGATCATCCAATCCAGTTGCAGTACTTTTCGATACACTTCTTCATCCA
GATGCTGACTTTGGGTATGATTATCCATCCGTTTTGCATTGGAAATTAGAGCAACATCATTATATCCCTCACGTAGTTCTTGGTAAAGGT
CCACCTGGTGGGGCTTGGCATGAATCATGTGGATCCTCTCAGCTCCATGAAAATAGTGGTTCTCCTGAAACTTCAAGGTCCCTGCCAGCT
CCTCAAGACAATGATTTTTTATCTAGAAAAGCTCAAGACTGTTATTTTATGAAGCTGCATCACTGTCCTGGAAATCACAGTTGGGATAGC
ACCATTTCTGGATCTCAAAGGGCTGCATTCTGTGATCACAAGACCACTCCATGCTCTTCAGCAATAATAAATCCACTCTCAACTGCAGGA
AACTCAGAACGTCTGCAGCCTGGTATAGCCCAGCAGTGGATCCAGAGCAAAAGGGAAGACATTGTGAACCAAATGACAGAAGCCTGCCTT
AACCAGTCGCTAGATGCCCTTCTGTCCAGGGACTTGATCATGAAAGAGGACTATGAACTTGTTAGTACCAAGCCTACAAGGACCTCAAAA
GTCAGACAATTACTAGACACTACTGACATCCAAGGAGAAGAATTTGCCAAAGTTATAGTACAAAAATTGAAAGATAACAAACAAATGGGT
CTTCAGCCTTACCCGGAAATACTTGTGGTTTCTAGATCACCATCTTTAAATTTACTTCAAAATAAAAGCATGTAAGTGACTGTTTTTCAA

>61903_61903_12_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000520659_RIPK2_chr8_90798821_ENST00000540020_length(amino acids)=373AA_BP=176
MPVWCCRCSLAGHFRNYSDTETEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEA
IHPNTILNSKLEEARHLSIVDQDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHESCG
SSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQ
QWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVS

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Fusion Gene PPI Analysis for OSGIN2-RIPK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OSGIN2-RIPK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OSGIN2-RIPK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource