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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OSMR-NCKAP5 (FusionGDB2 ID:61909)

Fusion Gene Summary for OSMR-NCKAP5

check button Fusion gene summary
Fusion gene informationFusion gene name: OSMR-NCKAP5
Fusion gene ID: 61909
HgeneTgene
Gene symbol

OSMR

NCKAP5

Gene ID

9180

344148

Gene nameoncostatin M receptorNCK associated protein 5
SynonymsIL-31R-beta|IL-31RB|OSMRB|OSMRbeta|PLCA1ERIH1|ERIH2|NAP5
Cytomap

5p13.1

2q21.2

Type of geneprotein-codingprotein-coding
Descriptiononcostatin-M-specific receptor subunit betaIL-31 receptor subunit betaIL-31R subunit betainterleukin-31 receptor subunit betaoncostatin-M specific receptor beta subunitnck-associated protein 5NAP-5peripheral clock protein 2
Modification date2020031320200313
UniProtAcc.

Q9HCH0

Ensembl transtripts involved in fusion geneENST00000274276, ENST00000502536, 
ENST00000473859, ENST00000317721, 
ENST00000405974, ENST00000409213, 
ENST00000409261, 
Fusion gene scores* DoF score4 X 3 X 3=3614 X 14 X 5=980
# samples 415
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/980*10)=-2.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OSMR [Title/Abstract] AND NCKAP5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOSMR(38886292)-NCKAP5(133554302), # samples:1
Anticipated loss of major functional domain due to fusion event.OSMR-NCKAP5 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOSMR

GO:0034097

response to cytokine

8999038


check buttonFusion gene breakpoints across OSMR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NCKAP5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-3918-01BOSMRchr5

38886292

-NCKAP5chr2

133554302

-


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Fusion Gene ORF analysis for OSMR-NCKAP5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000274276ENST00000473859OSMRchr5

38886292

-NCKAP5chr2

133554302

-
5CDS-intronENST00000502536ENST00000473859OSMRchr5

38886292

-NCKAP5chr2

133554302

-
Frame-shiftENST00000274276ENST00000317721OSMRchr5

38886292

-NCKAP5chr2

133554302

-
Frame-shiftENST00000274276ENST00000405974OSMRchr5

38886292

-NCKAP5chr2

133554302

-
Frame-shiftENST00000274276ENST00000409213OSMRchr5

38886292

-NCKAP5chr2

133554302

-
Frame-shiftENST00000274276ENST00000409261OSMRchr5

38886292

-NCKAP5chr2

133554302

-
In-frameENST00000502536ENST00000317721OSMRchr5

38886292

-NCKAP5chr2

133554302

-
In-frameENST00000502536ENST00000405974OSMRchr5

38886292

-NCKAP5chr2

133554302

-
In-frameENST00000502536ENST00000409213OSMRchr5

38886292

-NCKAP5chr2

133554302

-
In-frameENST00000502536ENST00000409261OSMRchr5

38886292

-NCKAP5chr2

133554302

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000502536OSMRchr538886292-ENST00000409261NCKAP5chr2133554302-79991588157965101643
ENST00000502536OSMRchr538886292-ENST00000409213NCKAP5chr2133554302-27941588811124347
ENST00000502536OSMRchr538886292-ENST00000405974NCKAP5chr2133554302-25541588811124347
ENST00000502536OSMRchr538886292-ENST00000317721NCKAP5chr2133554302-65111588157965101644

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000502536ENST00000409261OSMRchr538886292-NCKAP5chr2133554302-0.0067053840.99329454
ENST00000502536ENST00000409213OSMRchr538886292-NCKAP5chr2133554302-0.0026882280.99731183
ENST00000502536ENST00000405974OSMRchr538886292-NCKAP5chr2133554302-0.0030301090.9969699
ENST00000502536ENST00000317721OSMRchr538886292-NCKAP5chr2133554302-0.0125424170.9874576

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Fusion Genomic Features for OSMR-NCKAP5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for OSMR-NCKAP5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:38886292/chr2:133554302)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NCKAP5

Q9HCH0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573). {ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNCKAP5chr5:38886292chr2:133554302ENST000003177218181080_11302691910.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr5:38886292chr2:133554302ENST00000317721818331_3862691910.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr5:38886292chr2:133554302ENST00000317721818927_9332691910.0Compositional biasNote=Poly-Pro
TgeneNCKAP5chr5:38886292chr2:133554302ENST000004059748161080_1130269591.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr5:38886292chr2:133554302ENST00000405974816331_386269591.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr5:38886292chr2:133554302ENST00000405974816927_933269591.0Compositional biasNote=Poly-Pro
TgeneNCKAP5chr5:38886292chr2:133554302ENST0000040921310181080_1130269591.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr5:38886292chr2:133554302ENST000004092131018331_386269591.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr5:38886292chr2:133554302ENST000004092131018927_933269591.0Compositional biasNote=Poly-Pro
TgeneNCKAP5chr5:38886292chr2:133554302ENST0000040926110201080_11302691910.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr5:38886292chr2:133554302ENST000004092611020331_3862691910.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr5:38886292chr2:133554302ENST000004092611020927_9332691910.0Compositional biasNote=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOSMRchr5:38886292chr2:133554302ENST00000274276-718335_428330980.0DomainFibronectin type-III 1
HgeneOSMRchr5:38886292chr2:133554302ENST00000274276-718433_528330980.0DomainFibronectin type-III 2
HgeneOSMRchr5:38886292chr2:133554302ENST00000274276-718529_623330980.0DomainFibronectin type-III 3
HgeneOSMRchr5:38886292chr2:133554302ENST00000274276-718625_736330980.0DomainFibronectin type-III 4
HgeneOSMRchr5:38886292chr2:133554302ENST00000502536-17335_4280343.0DomainFibronectin type-III 1
HgeneOSMRchr5:38886292chr2:133554302ENST00000502536-17433_5280343.0DomainFibronectin type-III 2
HgeneOSMRchr5:38886292chr2:133554302ENST00000502536-17529_6230343.0DomainFibronectin type-III 3
HgeneOSMRchr5:38886292chr2:133554302ENST00000502536-17625_7360343.0DomainFibronectin type-III 4
HgeneOSMRchr5:38886292chr2:133554302ENST00000274276-718415_419330980.0MotifNote=WSXWS motif
HgeneOSMRchr5:38886292chr2:133554302ENST00000274276-718770_778330980.0MotifNote=Box 1 motif
HgeneOSMRchr5:38886292chr2:133554302ENST00000502536-17415_4190343.0MotifNote=WSXWS motif
HgeneOSMRchr5:38886292chr2:133554302ENST00000502536-17770_7780343.0MotifNote=Box 1 motif
HgeneOSMRchr5:38886292chr2:133554302ENST00000274276-71828_740330980.0Topological domainExtracellular
HgeneOSMRchr5:38886292chr2:133554302ENST00000274276-718762_979330980.0Topological domainCytoplasmic
HgeneOSMRchr5:38886292chr2:133554302ENST00000502536-1728_7400343.0Topological domainExtracellular
HgeneOSMRchr5:38886292chr2:133554302ENST00000502536-17762_9790343.0Topological domainCytoplasmic
HgeneOSMRchr5:38886292chr2:133554302ENST00000274276-718741_761330980.0TransmembraneHelical
HgeneOSMRchr5:38886292chr2:133554302ENST00000502536-17741_7610343.0TransmembraneHelical
TgeneNCKAP5chr5:38886292chr2:133554302ENST0000031772181871_2532691910.0Coiled coilOntology_term=ECO:0000255
TgeneNCKAP5chr5:38886292chr2:133554302ENST0000040597481671_253269591.0Coiled coilOntology_term=ECO:0000255
TgeneNCKAP5chr5:38886292chr2:133554302ENST00000409213101871_253269591.0Coiled coilOntology_term=ECO:0000255
TgeneNCKAP5chr5:38886292chr2:133554302ENST00000409261102071_2532691910.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for OSMR-NCKAP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61909_61909_1_OSMR-NCKAP5_OSMR_chr5_38886292_ENST00000502536_NCKAP5_chr2_133554302_ENST00000317721_length(transcript)=6511nt_BP=1588nt
GCGGCCGCCTCCCCCCGGGACTGAAGGGAGGGAATTCCTGTGGGTCCCAGGAGTGCCAAGAGTGCGCAGCAAGACGGGAAATTGCAAAAG
ACCTCACCCCTCTGCCCTCCCCCGCGGTTTTCCAGTAACTCCCGCCCCTCCGCGCTTGCCCCGCAGCTGATTCATAGCCCCGGCCCGGGC
CGCCTCTGCACGTCCGCCCCGGAGCCCGCACCCGCGCCCCACGCGCCGCCGAGGACTCGGCCCGGCTCGTGGAGCCCTTCGCCCGCGGCA
AAACCAGAACTGATGGCTCTATTTGCAGTCTTTCAGACAACATTCTTCTTAACATTGCTGTCCTTGAGGACTTACCAGAGTGAAGTCTTG
GCTGAACGTTTACCATTGACTCCTGTATCACTTAAAGTTTCCACCAATTCTACGCGTCAGAGTTTGCACTTACAATGGACTGTCCACAAC
CTTCCTTATCATCAGGAATTGAAAATGGTATTTCAGATCCAGATCAGTAGGATTGAAACATCCAATGTCATCTGGGTGGGGAATTACAGC
ACCACTGTGAAGTGGAACCAGGTTCTGCATTGGAGCTGGGAATCTGAGCTCCCTTTGGAATGTGCCACACACTTTGTAAGAATAAAGAGT
TTGGTGGACGATGCCAAGTTCCCTGAGCCAAATTTCTGGAGCAACTGGAGTTCCTGGGAGGAAGTCAGTGTACAAGATTCTACTGGACAG
GATATATTGTTCGTTTTCCCTAAAGATAAGCTGGTGGAAGAAGGCACCAATGTTACCATTTGTTACGTTTCTAGGAACATTCAAAATAAT
GTATCCTGTTATTTGGAAGGGAAACAGATTCATGGAGAACAACTTGATCCACATGTAACTGCATTCAACTTGAATAGTGTGCCTTTCATT
AGGAATAAAGGGACAAATATCTATTGTGAGGCAAGTCAAGGAAATGTCAGTGAAGGCATGAAAGGCATCGTTCTTTTTGTCTCAAAAGTA
CTTGAGGAGCCCAAGGACTTTTCTTGTGAAACCGAGGACTTCAAGACTTTGCACTGTACTTGGGATCCTGGGACGGACACTGCCTTGGGG
TGGTCTAAACAACCTTCCCAAAGCTACACTTTATTTGAATCGTGAGACTAGAGTTGTCACAGCCCACCGTGGCCACTAACGTGTCTTTGT
TTCACAGACTGTGTGATCAAGTAAATGTGCTGTAGATCTTTGCCTCATTCACAGCGGAGGTGAGAGTTAGAATTTATACCTATTGTTCAT
GCCACGTTTCTCCTCATGGATGCACGCATCCCCTATTATTTGTTTCTTTTAATAATGTCACGAGCACCAATGAGCTTACTACCCAACTTC
AAAACTAGGACTCTAACAATAACTTCTGTCATATCTCATCCTGTAACGCCCCCACCTTCGCTCCTTCCGCCAAGATAATTATCACTTTAA
ATTGTGTGCGTGTGTATTCTCATTTCTTATGTGATGGTAAAAATGCCTTTATTTTGTTTGGTTTTAATGCATAGAAAGGACATCAAGCTG
TATGTAATAATTCAGTAATTATGTTTATATAATATTAAATTGCTAATATTTGCCCATAAAACTTCACTCACGTCTCTTGGATCTTTCATC
TGGAGATTTGCTTTCAGAGGTGGAAAGAAACCGAAGTCTGACACAGTCACGAACTGATGCTGAGGTGCACGAACACCAACTAAATACAAA
ATCGGCCTTGAAATGCCCTGGCTTGGGGGCTGTCATCCCTGGTCATCTCTGTCCTCGAAACAGCTACAGTAGCAGCAGTGAACTGTCTCT
TTCAAGCACCTGCAGCGAGTACTCCAGTGGCTCCTCCTACACGTGGCACGATGGGAAGAACCTCAGGAAAAGGCAATCATCACAAAACTG
GGATAAAAGGCTAAGTATTGATTCTTCGCTCCCAAGTGGCTTTGCTAGTCCTACAAATGAACTACCTCCAACTCGTATCAAGGAAAGCCA
CATTTTGGAAGGGCTAAGAAAGCTACAGAAGCGAAAAGTGTTACTTGAACCCCCATCAGTGATAACCAAATGGGGTTATAAAGATTGCAT
GAACTCGAATGAAGGAATATATTCTCCTGGAATTAAAAGTAGCAGCCTCAAGGAGTATCCCCCCTGCAAAACAGCTGACCTGGGGAGCCC
CTGCAAGGAACCCCACAAGACATTTGTTTATGATCTAGATTCCCACGTTGATGCGGACGATGACCCTTCCACCTTAGCATTGCTCCAAGC
AGTTCCAAACCAGAGCTGCAGGCCACATGGCAGTAAATTAACCCACAGTGTTTCCGACAGTCTGTTTGGCTGGGAGACAAACAGAAAACA
CTTTCTGGAAGGCACATCCTCAGTTTATCCCAAGGAAAGGCCTGAAAAGCTGACAAGTTGCGCCAGCAGCTGTCCCTTAGAGATGAAGCT
GTGCCCAAGTGTGCAGACGCCTCAGGTACAGAGGGAGAGGGGCCCACAGGGCCAAGGCCATGGCCGCATGGCTCTCAACCTCCAGCTTTC
AGACACTGATGACAATGAAACGTTTGATGAGCTGCACATAGAGAGCAGTGATGAGAAAAGTCCTTCAGACGTGTCATTGGCTGCCGACAC
CGATAAGTCCGTGGAGAACCTGGATGTCCTTGTGGGGTTTGGAAAATCTCTATGTGGGTCTCCTGAAGAGGAGGAAAAACAAGTGCCCAT
CCCTTCAGAGACTAGGCCAAAGACTTTTAGTTTCATTAAGCAGCAAAGAGTTGTAAAAAGGACTTCTTCAGAAGAATGTGTGACTGTGAT
ATTTGATGCGGAAGACGGTGAGCCCATTGAATTCAGCTCTCACCAGACTGGGGTTGTCACTGTTACCAGAAATGAGATTTCCATCAATTC
AACTCCTGCTGGACCCAAGGCAGAACATACTGAGCTTTTACCTCAGGGAATTGCTTGTTTACAGCCAAGAGCTGCTGCAAGAGACTATAC
TTTCTTTAAAAGGTCTGAAGAGGACACTGAGAAAAACATTCCAAAAGATAATGTAGATAATGTTCCCAGGGTGTCCACTGAATCTTTCAG
CTCCAGGACAGTGACACAAAATCCTCAGCAGCAAAAGCTGGTCAAACCAACACACAATATATCATGCCAGAGTAATTCCAGGTCTTCGGC
ACCCATGGGCATCTATCAAAAGCAAAATCTGACAAAAATACCTCCCAGGGGCAAGTCTTCACCTCAGAAATCAAAACTAATGGAGCCCGA
AGCCACCACACTACTCCCTTCATCTGGCCTGGTGACTCTTGAAAAATCACCAGCCTTAGCTCCTGGGAAACTCTCACGATTCATGAAGAC
TGAGAGCTCAGGGCCCCTCTTTGAATTACGATCAGATCCACACATTCCAAAACATTCCGCCCAACTTCCGCACAGCTCCAGGATGCCCAG
CAGGAGGGACTGGGTCCAGTGCCCCAAGAGTCAGACTCCAGGGTCACGGTCAAGGCCTGCCATTGAGTCTAGTGACAGTGGAGAGCCCCC
CACGAGGGATGAACACTGTGGCTCTGGGCCGGAGGCAGGGGTGAAATCCCCTTCCCCTCCGCCCCCTCCAGGCAGGTCCGTCTCCCTGCT
GGCCAGGCCCAGCTATGACTATTCACCAGCACCTTCATCCACCAAGTCCGAAACCAGGGTCCCCAGTGAAACAGCAAGGACCCCATTCAA
ATCCCCGCTGCTGAAAGGAATTTCTGCTCCAGTTATTTCTTCTAATCCGGCCACGACAGAAGTGCAGAGGAAGAAACCTTCTGTGGCCTT
CAAAAAGCCTATCTTCACTCACCCTATGCCCTCCCCAGAAGCAGTCATTCAAACCCGATGCCCTGCTCATGCCCCCTCCAGCTCCTTCAC
CGTAATGGCTCTGGGGCCTCCAAAGGTCTCTCCGAAGAGAGGTGTCCCCAAAACCTCTCCTCGCCAAACACTTGGGACCCCACAAAGGGA
CATAGGATTACAGACTCCCAGGATCTCTCCTTCAACCCATGAGCCACTGGAAATGACGTCCTCCAAAAGTGTATCTCCAGGGAGAAAAGG
ACAATTGAATGATAGCGCCTCCACACCCCCCAAGCCTTCCTTCTTAGGGGTAAATGAGTCACCATCATCTCAGGTCAGCAGTTCCTCATC
ATCCTCATCACCCGCCAAAAGCCATAACAGCCCTCATGGTTGTCAAAGTGCTCATGAGAAAGGACTGAAAACTCGCCTTCCAGTGGGACT
CAAAGTGCTCATGAAGTCTCCCCAGCTGCTCAGGAAAAGTTCCACCGTGCCAGGGAAACATGAAAAAGACAGTTTAAATGAAGCCTCCAA
AAGTTCCGTGGCTGTGAACAAGTCTAAGCCAGAGGACTCCAAGAATCCAGCAAGCATGGAGATCACAGCGGGTGAAAGAAATGTGACCCT
ACCGGATTCACAAGCACAGGGCAGTTTAGCTGATGGGCTTCCCCTGGAAACAGCACTACAAGAGCCATTGGAAAGTAGCATCCCTGGGAG
TGATGGAAGGGATGGGGTAGATAATAGATCCATGAGAAGATCCCTTTCCTCCAGCAAACCACACCTAAAACCAGCTCTGGGTATGAATGG
CGCCAAAGCCCGCAGCCACAGCTTCAGTACACACTCAGGAGACAAGCCTTCTACGCCCCCCATCGAAGGGTCAGGCAAAGTCCGCACTCA
GATCATTACCAATACCGCCGAGAGAGGCAATTCTCTTACCCGGCAGAACTCTTCCACGGAAAGCTCTCCCAACAAGGCCCCTTCTGCTCC
CATGTTGGAGAGTCTCCCCAGTGTTGGGAGGCCCTCGGGGCACCCCTCCTCCGGGAAGGGCTCCCTGGGGAGCTCAGGCAGCTTCAGCAG
TCAGCATGGGAGCCCAAGTAAGTTGCCTTTGAGGATCCCTCCAAAGTCTGAGGGACTCCTCATCCCACCTGGAAAGGAAGACCAGCAGGC
CTTCACCCAGGGAGAGTGCCCCAGTGCCAATGTGGCTGTACTTGGGGAACCAGGCAGTGACCGCCGCAGTTGCCCACCCACCCCAACAGA
CTGCCCTGAAGCCCTGCAGAGCCCAGGGAGGACTCAGCATCCAAGCACTTTTGAAACAAGCAGTACATCCAAGCTAGAAACTTCTGGAAG
GCATCCAGATGCCTCTGCAACCGCGACTGATGCTGTGAGTTCAGAAGCCCCCCTCTCACCCACAATCGAAGAAAAGGTCATGTTGTGCAT
TCAGGAAAATGTGGAAAAGGGCCAAGTGCAAACAAAGCCCACCTCTGTGGAAGCAAAGCAGAAGCCTGGGCCTTCTTTTGCCAGCTGGTT
TGGTTTTCGGAAGAGTAGACTTCCAGCTCTGAGTAGCAGGAAAATGGACATCTCCAAAACCAAAGTAGAAAAGAAAGATGCAAAAGTCTT
GGGGTTTGGAAACAGACAACTAAAATCAGAAAGAAAAAAAGAGAAAAAGAAGCCTGAACTACAGTGTGAGACAGAAAATGAGCTTATCAA
GGACACCAAGTCAGCAGATAATCCAGATGGCGGTTTACAAAGCAAAAATAATCGGAGAACACCACAAGACATTTACAACCAACTGAAGAT
TGAACCAAGGAATAGACACAGCCCTGTTGCATGTTCAACGAAAGACACCTTCATGACGGAACTCTTGAACAGAGTTGATAAGAAAGCAGC
TCCACAGACAGAAAGTGGATCAAGTAATGCTTCCTGCAGGAATGTGTTAAAGGGCAGTTCTCAGGGCTCCTGTCTCATCGGCAGCTCTAT
CAGTACTCAAGGAAACCACAAGAAAAACATGAAAATCAAAGCCGATATGGAAGTACCAAAAGACTCCCTGGTAAAAGAGGCAAATGAAAA
CTTGCAAGAGGATGAAGACGATGCAGTTGCAGATTCTGTATTTCAGAGCCACATCATAGAATCCAACTGCCAGATGAGAACATTGGACAG
TGGGATCGGAACCTTTCCACTCCCAGACTCGGGAAATCGCTCGACAGGACGCTACCTATGCCAGCCAGACTCCCCAGAGGACGCTGAGCC
TCTCCTGCCTCTCCAGTCAGCCCTTTCTGCAGTTTCTTCCATGAGAGCCCAAACCCTTGAACGTGAAGTGCCTTCCTCCACAGACGGCCA
GCGCCCTGCAGATAGCGCCATTGTTCATTCCACATCCGACCCCATCATGACCGCCAGAGGGATGAGGCCTCTTCAGAGCCGCCTCCCCAA
ACCAGCTTCCTCAGGAAAAGTCAGTTCCCAAAAGCAGAATGAAGCAGAGCCAAGGCCTCAGACATGCTCATCATTCGGATATGCTGAAGA
CCCAATGGCAAGCCAGCCGCTTCCAGACTGGGGGAGTGAAGTTGCTGCCACCGGGACCCAGGACAAGGCACCCAGAATGTGTACGTACTC
TGCCAGCGGTGGCAGTAATAGTGACAGTGACCTGGACTATGGAGATAATGGTTTTGGAGCTGGAAGGGGACAGTTAGTGAAAGCACTGAA

>61909_61909_1_OSMR-NCKAP5_OSMR_chr5_38886292_ENST00000502536_NCKAP5_chr2_133554302_ENST00000317721_length(amino acids)=1644AA_BP=3
MPIKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWH
DGKNLRKRQSSQNWDKRLSIDSSLPSGFASPTNELPPTRIKESHILEGLRKLQKRKVLLEPPSVITKWGYKDCMNSNEGIYSPGIKSSSL
KEYPPCKTADLGSPCKEPHKTFVYDLDSHVDADDDPSTLALLQAVPNQSCRPHGSKLTHSVSDSLFGWETNRKHFLEGTSSVYPKERPEK
LTSCASSCPLEMKLCPSVQTPQVQRERGPQGQGHGRMALNLQLSDTDDNETFDELHIESSDEKSPSDVSLAADTDKSVENLDVLVGFGKS
LCGSPEEEEKQVPIPSETRPKTFSFIKQQRVVKRTSSEECVTVIFDAEDGEPIEFSSHQTGVVTVTRNEISINSTPAGPKAEHTELLPQG
IACLQPRAAARDYTFFKRSEEDTEKNIPKDNVDNVPRVSTESFSSRTVTQNPQQQKLVKPTHNISCQSNSRSSAPMGIYQKQNLTKIPPR
GKSSPQKSKLMEPEATTLLPSSGLVTLEKSPALAPGKLSRFMKTESSGPLFELRSDPHIPKHSAQLPHSSRMPSRRDWVQCPKSQTPGSR
SRPAIESSDSGEPPTRDEHCGSGPEAGVKSPSPPPPPGRSVSLLARPSYDYSPAPSSTKSETRVPSETARTPFKSPLLKGISAPVISSNP
ATTEVQRKKPSVAFKKPIFTHPMPSPEAVIQTRCPAHAPSSSFTVMALGPPKVSPKRGVPKTSPRQTLGTPQRDIGLQTPRISPSTHEPL
EMTSSKSVSPGRKGQLNDSASTPPKPSFLGVNESPSSQVSSSSSSSSPAKSHNSPHGCQSAHEKGLKTRLPVGLKVLMKSPQLLRKSSTV
PGKHEKDSLNEASKSSVAVNKSKPEDSKNPASMEITAGERNVTLPDSQAQGSLADGLPLETALQEPLESSIPGSDGRDGVDNRSMRRSLS
SSKPHLKPALGMNGAKARSHSFSTHSGDKPSTPPIEGSGKVRTQIITNTAERGNSLTRQNSSTESSPNKAPSAPMLESLPSVGRPSGHPS
SGKGSLGSSGSFSSQHGSPSKLPLRIPPKSEGLLIPPGKEDQQAFTQGECPSANVAVLGEPGSDRRSCPPTPTDCPEALQSPGRTQHPST
FETSSTSKLETSGRHPDASATATDAVSSEAPLSPTIEEKVMLCIQENVEKGQVQTKPTSVEAKQKPGPSFASWFGFRKSRLPALSSRKMD
ISKTKVEKKDAKVLGFGNRQLKSERKKEKKKPELQCETENELIKDTKSADNPDGGLQSKNNRRTPQDIYNQLKIEPRNRHSPVACSTKDT
FMTELLNRVDKKAAPQTESGSSNASCRNVLKGSSQGSCLIGSSISTQGNHKKNMKIKADMEVPKDSLVKEANENLQEDEDDAVADSVFQS
HIIESNCQMRTLDSGIGTFPLPDSGNRSTGRYLCQPDSPEDAEPLLPLQSALSAVSSMRAQTLEREVPSSTDGQRPADSAIVHSTSDPIM
TARGMRPLQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPMASQPLPDWGSEVAATGTQDKAPRMCTYSASGGSNSDSDLDYGDN

--------------------------------------------------------------
>61909_61909_2_OSMR-NCKAP5_OSMR_chr5_38886292_ENST00000502536_NCKAP5_chr2_133554302_ENST00000405974_length(transcript)=2554nt_BP=1588nt
GCGGCCGCCTCCCCCCGGGACTGAAGGGAGGGAATTCCTGTGGGTCCCAGGAGTGCCAAGAGTGCGCAGCAAGACGGGAAATTGCAAAAG
ACCTCACCCCTCTGCCCTCCCCCGCGGTTTTCCAGTAACTCCCGCCCCTCCGCGCTTGCCCCGCAGCTGATTCATAGCCCCGGCCCGGGC
CGCCTCTGCACGTCCGCCCCGGAGCCCGCACCCGCGCCCCACGCGCCGCCGAGGACTCGGCCCGGCTCGTGGAGCCCTTCGCCCGCGGCA
AAACCAGAACTGATGGCTCTATTTGCAGTCTTTCAGACAACATTCTTCTTAACATTGCTGTCCTTGAGGACTTACCAGAGTGAAGTCTTG
GCTGAACGTTTACCATTGACTCCTGTATCACTTAAAGTTTCCACCAATTCTACGCGTCAGAGTTTGCACTTACAATGGACTGTCCACAAC
CTTCCTTATCATCAGGAATTGAAAATGGTATTTCAGATCCAGATCAGTAGGATTGAAACATCCAATGTCATCTGGGTGGGGAATTACAGC
ACCACTGTGAAGTGGAACCAGGTTCTGCATTGGAGCTGGGAATCTGAGCTCCCTTTGGAATGTGCCACACACTTTGTAAGAATAAAGAGT
TTGGTGGACGATGCCAAGTTCCCTGAGCCAAATTTCTGGAGCAACTGGAGTTCCTGGGAGGAAGTCAGTGTACAAGATTCTACTGGACAG
GATATATTGTTCGTTTTCCCTAAAGATAAGCTGGTGGAAGAAGGCACCAATGTTACCATTTGTTACGTTTCTAGGAACATTCAAAATAAT
GTATCCTGTTATTTGGAAGGGAAACAGATTCATGGAGAACAACTTGATCCACATGTAACTGCATTCAACTTGAATAGTGTGCCTTTCATT
AGGAATAAAGGGACAAATATCTATTGTGAGGCAAGTCAAGGAAATGTCAGTGAAGGCATGAAAGGCATCGTTCTTTTTGTCTCAAAAGTA
CTTGAGGAGCCCAAGGACTTTTCTTGTGAAACCGAGGACTTCAAGACTTTGCACTGTACTTGGGATCCTGGGACGGACACTGCCTTGGGG
TGGTCTAAACAACCTTCCCAAAGCTACACTTTATTTGAATCGTGAGACTAGAGTTGTCACAGCCCACCGTGGCCACTAACGTGTCTTTGT
TTCACAGACTGTGTGATCAAGTAAATGTGCTGTAGATCTTTGCCTCATTCACAGCGGAGGTGAGAGTTAGAATTTATACCTATTGTTCAT
GCCACGTTTCTCCTCATGGATGCACGCATCCCCTATTATTTGTTTCTTTTAATAATGTCACGAGCACCAATGAGCTTACTACCCAACTTC
AAAACTAGGACTCTAACAATAACTTCTGTCATATCTCATCCTGTAACGCCCCCACCTTCGCTCCTTCCGCCAAGATAATTATCACTTTAA
ATTGTGTGCGTGTGTATTCTCATTTCTTATGTGATGGTAAAAATGCCTTTATTTTGTTTGGTTTTAATGCATAGAAAGGACATCAAGCTG
TATGTAATAATTCAGTAATTATGTTTATATAATATTAAATTGCTAATATTTGCCCATAAAACTTCACTCACGTCTCTTGGATCTTTCATC
TGGAGATTTGCTTTCAGAGGTGGAAAGAAACCGAAGTCTGACACAGTCACGAACTGATGCTGAGGTGCACGAACACCAACTAAATACAAA
ATCGGCCTTGAAATGCCCTGGCTTGGGGGCTGTCATCCCTGGTCATCTCTGTCCTCGAAACAGCTACAGTAGCAGCAGTGAACTGTCTCT
TTCAAGCACCTGCAGCGAGTACTCCAGTGGCTCCTCCTACACGTGGCACGATGGGAAGAACCTCAGGAAAAGGGTAAAAGAGGCAAATGA
AAACTTGCAAGAGGATGAAGACGATGCAGTTGCAGATTCTGTATTTCAGAGCCACATCATAGAATCCAACTGCCAGATGAGAACATTGGA
CAGTGGGATCGGAACCTTTCCACTCCCAGACTCGGGAAATCGCTCGACAGGACGCTACCTATGCCAGCCAGACTCCCCAGAGGACGCTGA
GCCTCTCCTGCCTCTCCAGTCAGCCCTTTCTGCAGTTTCTTCCATGAGAGCCCAAACCCTTGAACGTGAAGTGCCTTCCTCCACAGACGG
CCAGCGCCCTGCAGATAGCGCCATTGTTCATTCCACATCCGACCCCATCATGACCGCCAGAGGGATGAGGCCTCTTCAGAGCCGCCTCCC
CAAACCAGCTTCCTCAGGAAAAGTCAGTTCCCAAAAGCAGAATGAAGCAGAGCCAAGGCCTCAGACATGCTCATCATTCGGATATGCTGA
AGACCCAATGGCAAGCCAGCCGCTTCCAGACTGGGGGAGTGAAGTTGCTGCCACCGGGACCCAGGACAAGGCACCCAGAATGTGTACGTA
CTCTGCCAGCGGTGGCAGTAATAGTGACAGTGACCTGGACTATGGAGATAATGGTTTTGGAGCTGGAAGGGGACAGTTAGTGAAAGCACT

>61909_61909_2_OSMR-NCKAP5_OSMR_chr5_38886292_ENST00000502536_NCKAP5_chr2_133554302_ENST00000405974_length(amino acids)=347AA_BP=
MQKTSPLCPPPRFSSNSRPSALAPQLIHSPGPGRLCTSAPEPAPAPHAPPRTRPGSWSPSPAAKPELMALFAVFQTTFFLTLLSLRTYQS
EVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVR
IKSLVDDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSV

--------------------------------------------------------------
>61909_61909_3_OSMR-NCKAP5_OSMR_chr5_38886292_ENST00000502536_NCKAP5_chr2_133554302_ENST00000409213_length(transcript)=2794nt_BP=1588nt
GCGGCCGCCTCCCCCCGGGACTGAAGGGAGGGAATTCCTGTGGGTCCCAGGAGTGCCAAGAGTGCGCAGCAAGACGGGAAATTGCAAAAG
ACCTCACCCCTCTGCCCTCCCCCGCGGTTTTCCAGTAACTCCCGCCCCTCCGCGCTTGCCCCGCAGCTGATTCATAGCCCCGGCCCGGGC
CGCCTCTGCACGTCCGCCCCGGAGCCCGCACCCGCGCCCCACGCGCCGCCGAGGACTCGGCCCGGCTCGTGGAGCCCTTCGCCCGCGGCA
AAACCAGAACTGATGGCTCTATTTGCAGTCTTTCAGACAACATTCTTCTTAACATTGCTGTCCTTGAGGACTTACCAGAGTGAAGTCTTG
GCTGAACGTTTACCATTGACTCCTGTATCACTTAAAGTTTCCACCAATTCTACGCGTCAGAGTTTGCACTTACAATGGACTGTCCACAAC
CTTCCTTATCATCAGGAATTGAAAATGGTATTTCAGATCCAGATCAGTAGGATTGAAACATCCAATGTCATCTGGGTGGGGAATTACAGC
ACCACTGTGAAGTGGAACCAGGTTCTGCATTGGAGCTGGGAATCTGAGCTCCCTTTGGAATGTGCCACACACTTTGTAAGAATAAAGAGT
TTGGTGGACGATGCCAAGTTCCCTGAGCCAAATTTCTGGAGCAACTGGAGTTCCTGGGAGGAAGTCAGTGTACAAGATTCTACTGGACAG
GATATATTGTTCGTTTTCCCTAAAGATAAGCTGGTGGAAGAAGGCACCAATGTTACCATTTGTTACGTTTCTAGGAACATTCAAAATAAT
GTATCCTGTTATTTGGAAGGGAAACAGATTCATGGAGAACAACTTGATCCACATGTAACTGCATTCAACTTGAATAGTGTGCCTTTCATT
AGGAATAAAGGGACAAATATCTATTGTGAGGCAAGTCAAGGAAATGTCAGTGAAGGCATGAAAGGCATCGTTCTTTTTGTCTCAAAAGTA
CTTGAGGAGCCCAAGGACTTTTCTTGTGAAACCGAGGACTTCAAGACTTTGCACTGTACTTGGGATCCTGGGACGGACACTGCCTTGGGG
TGGTCTAAACAACCTTCCCAAAGCTACACTTTATTTGAATCGTGAGACTAGAGTTGTCACAGCCCACCGTGGCCACTAACGTGTCTTTGT
TTCACAGACTGTGTGATCAAGTAAATGTGCTGTAGATCTTTGCCTCATTCACAGCGGAGGTGAGAGTTAGAATTTATACCTATTGTTCAT
GCCACGTTTCTCCTCATGGATGCACGCATCCCCTATTATTTGTTTCTTTTAATAATGTCACGAGCACCAATGAGCTTACTACCCAACTTC
AAAACTAGGACTCTAACAATAACTTCTGTCATATCTCATCCTGTAACGCCCCCACCTTCGCTCCTTCCGCCAAGATAATTATCACTTTAA
ATTGTGTGCGTGTGTATTCTCATTTCTTATGTGATGGTAAAAATGCCTTTATTTTGTTTGGTTTTAATGCATAGAAAGGACATCAAGCTG
TATGTAATAATTCAGTAATTATGTTTATATAATATTAAATTGCTAATATTTGCCCATAAAACTTCACTCACGTCTCTTGGATCTTTCATC
TGGAGATTTGCTTTCAGAGGTGGAAAGAAACCGAAGTCTGACACAGTCACGAACTGATGCTGAGGTGCACGAACACCAACTAAATACAAA
ATCGGCCTTGAAATGCCCTGGCTTGGGGGCTGTCATCCCTGGTCATCTCTGTCCTCGAAACAGCTACAGTAGCAGCAGTGAACTGTCTCT
TTCAAGCACCTGCAGCGAGTACTCCAGTGGCTCCTCCTACACGTGGCACGATGGGAAGAACCTCAGGAAAAGGGTAAAAGAGGCAAATGA
AAACTTGCAAGAGGATGAAGACGATGCAGTTGCAGATTCTGTATTTCAGAGCCACATCATAGAATCCAACTGCCAGATGAGAACATTGGA
CAGTGGGATCGGAACCTTTCCACTCCCAGACTCGGGAAATCGCTCGACAGGACGCTACCTATGCCAGCCAGACTCCCCAGAGGACGCTGA
GCCTCTCCTGCCTCTCCAGTCAGCCCTTTCTGCAGTTTCTTCCATGAGAGCCCAAACCCTTGAACGTGAAGTGCCTTCCTCCACAGACGG
CCAGCGCCCTGCAGATAGCGCCATTGTTCATTCCACATCCGACCCCATCATGACCGCCAGAGGGATGAGGCCTCTTCAGAGCCGCCTCCC
CAAACCAGCTTCCTCAGGAAAAGTCAGTTCCCAAAAGCAGAATGAAGCAGAGCCAAGGCCTCAGACATGCTCATCATTCGGATATGCTGA
AGACCCAATGGCAAGCCAGCCGCTTCCAGACTGGGGGAGTGAAGTTGCTGCCACCGGGACCCAGGACAAGGCACCCAGAATGTGTACGTA
CTCTGCCAGCGGTGGCAGTAATAGTGACAGTGACCTGGACTATGGAGATAATGGTTTTGGAGCTGGAAGGGGACAGTTAGTGAAAGCACT
GAAGAGCGCTGCCCCAGAAATTGAGACAACTTGAAGAAACAAAAGACGATCCCGAGAATAGATTATCGAAAATTTCCCTAGAGTCATTCA
ATAAATTTAACAGCAATACTGTGATTTTATTAGAAAAAGAGAAGAACTCTCTGAACAAGGTTGAAGGACAGAAGGAAGAAAAAGAAAAAA
ATGAAGAGACATCTTTGAGTAGTTCAGATAGGCCTGGGGTAGACAACTTGGAATCTTTGAGTGATTCTTTATATGATAGCTTCTCTTCCT

>61909_61909_3_OSMR-NCKAP5_OSMR_chr5_38886292_ENST00000502536_NCKAP5_chr2_133554302_ENST00000409213_length(amino acids)=347AA_BP=
MQKTSPLCPPPRFSSNSRPSALAPQLIHSPGPGRLCTSAPEPAPAPHAPPRTRPGSWSPSPAAKPELMALFAVFQTTFFLTLLSLRTYQS
EVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVR
IKSLVDDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSV

--------------------------------------------------------------
>61909_61909_4_OSMR-NCKAP5_OSMR_chr5_38886292_ENST00000502536_NCKAP5_chr2_133554302_ENST00000409261_length(transcript)=7999nt_BP=1588nt
GCGGCCGCCTCCCCCCGGGACTGAAGGGAGGGAATTCCTGTGGGTCCCAGGAGTGCCAAGAGTGCGCAGCAAGACGGGAAATTGCAAAAG
ACCTCACCCCTCTGCCCTCCCCCGCGGTTTTCCAGTAACTCCCGCCCCTCCGCGCTTGCCCCGCAGCTGATTCATAGCCCCGGCCCGGGC
CGCCTCTGCACGTCCGCCCCGGAGCCCGCACCCGCGCCCCACGCGCCGCCGAGGACTCGGCCCGGCTCGTGGAGCCCTTCGCCCGCGGCA
AAACCAGAACTGATGGCTCTATTTGCAGTCTTTCAGACAACATTCTTCTTAACATTGCTGTCCTTGAGGACTTACCAGAGTGAAGTCTTG
GCTGAACGTTTACCATTGACTCCTGTATCACTTAAAGTTTCCACCAATTCTACGCGTCAGAGTTTGCACTTACAATGGACTGTCCACAAC
CTTCCTTATCATCAGGAATTGAAAATGGTATTTCAGATCCAGATCAGTAGGATTGAAACATCCAATGTCATCTGGGTGGGGAATTACAGC
ACCACTGTGAAGTGGAACCAGGTTCTGCATTGGAGCTGGGAATCTGAGCTCCCTTTGGAATGTGCCACACACTTTGTAAGAATAAAGAGT
TTGGTGGACGATGCCAAGTTCCCTGAGCCAAATTTCTGGAGCAACTGGAGTTCCTGGGAGGAAGTCAGTGTACAAGATTCTACTGGACAG
GATATATTGTTCGTTTTCCCTAAAGATAAGCTGGTGGAAGAAGGCACCAATGTTACCATTTGTTACGTTTCTAGGAACATTCAAAATAAT
GTATCCTGTTATTTGGAAGGGAAACAGATTCATGGAGAACAACTTGATCCACATGTAACTGCATTCAACTTGAATAGTGTGCCTTTCATT
AGGAATAAAGGGACAAATATCTATTGTGAGGCAAGTCAAGGAAATGTCAGTGAAGGCATGAAAGGCATCGTTCTTTTTGTCTCAAAAGTA
CTTGAGGAGCCCAAGGACTTTTCTTGTGAAACCGAGGACTTCAAGACTTTGCACTGTACTTGGGATCCTGGGACGGACACTGCCTTGGGG
TGGTCTAAACAACCTTCCCAAAGCTACACTTTATTTGAATCGTGAGACTAGAGTTGTCACAGCCCACCGTGGCCACTAACGTGTCTTTGT
TTCACAGACTGTGTGATCAAGTAAATGTGCTGTAGATCTTTGCCTCATTCACAGCGGAGGTGAGAGTTAGAATTTATACCTATTGTTCAT
GCCACGTTTCTCCTCATGGATGCACGCATCCCCTATTATTTGTTTCTTTTAATAATGTCACGAGCACCAATGAGCTTACTACCCAACTTC
AAAACTAGGACTCTAACAATAACTTCTGTCATATCTCATCCTGTAACGCCCCCACCTTCGCTCCTTCCGCCAAGATAATTATCACTTTAA
ATTGTGTGCGTGTGTATTCTCATTTCTTATGTGATGGTAAAAATGCCTTTATTTTGTTTGGTTTTAATGCATAGAAAGGACATCAAGCTG
TATGTAATAATTCAGTAATTATGTTTATATAATATTAAATTGCTAATATTTGCCCATAAAACTTCACTCACGTCTCTTGGATCTTTCATC
TGGAGATTTGCTTTCAGAGGTGGAAAGAAACCGAAGTCTGACACAGTCACGAACTGATGCTGAGGTGCACGAACACCAACTAAATACAAA
ATCGGCCTTGAAATGCCCTGGCTTGGGGGCTGTCATCCCTGGTCATCTCTGTCCTCGAAACAGCTACAGTAGCAGCAGTGAACTGTCTCT
TTCAAGCACCTGCAGCGAGTACTCCAGTGGCTCCTCCTACACGTGGCACGATGGGAAGAACCTCAGGAAAAGGCAATCATCACAAAACTG
GGATAAAAGGCTAAGTATTGATTCTTCGCTCCCAAGTGGCTTTGCTAGTCCTACAAATGAACTACCTCCAACTCGTATCAAGGAAAGCCA
CATTTTGGAAGGGCTAAGAAAGCTACAGAAGCGAAAAGTGTTACTTGAACCCCCATCAGTGATAACCAAATGGGGTTATAAAGATTGCAT
GAACTCGAATGAAGGAATATATTCTCCTGGAATTAAAAGTAGCAGCCTCAAGGAGTATCCCCCCTGCAAAACAGCTGACCTGGGGAGCCC
CTGCAAGGAACCCCACAAGACATTTGTTTATGATCTAGATTCCCACGTTGATGCGGACGATGACCCTTCCACCTTAGCATTGCTCCAAGC
AGTTCCAAACCAGAGCTGCAGGCCACATGGCAGTAAATTAACCCACAGTGTTTCCGACAGTCTGTTTGGCTGGGAGACAAACAGAAAACA
CTTTCTGGAAGGCACATCCTCAGTTTATCCCAAGGAAAGGCCTGAAAAGCTGACAAGTTGCGCCAGCAGCTGTCCCTTAGAGATGAAGCT
GTGCCCAAGTGTGCAGACGCCTCAGGTACAGAGGGAGAGGGGCCCACAGGGCCAAGGCCATGGCCGCATGGCTCTCAACCTCCAGCTTTC
AGACACTGATGACAATGAAACGTTTGATGAGCTGCACATAGAGAGCAGTGATGAGAAAAGTCCTTCAGACGTGTCATTGGCTGCCGACAC
CGATAAGTCCGTGGAGAACCTGGATGTCCTTGTGGGGTTTGGAAAATCTCTATGTGGGTCTCCTGAAGAGGAGGAAAAACAAGTGCCCAT
CCCTTCAGAGACTAGGCCAAAGACTTTTAGTTTCATTAAGCAGCAAAGAGTTGTAAAAAGGACTTCTTCAGAAGAATGTGTGACTGTGAT
ATTTGATGCGGAAGACGGTGAGCCCATTGAATTCAGCTCTCACCAGACTGGGGTTGTCACTGTTACCAGAAATGAGATTTCCATCAATTC
AACTCCTGCTGGACCCAAGGCAGAACATACTGAGCTTTTACCTCAGGGAATTGCTTGTTTACAGCCAAGAGCTGCTGCAAGAGACTATAC
TTTCTTTAAAAGGTCTGAAGAGGACACTGAGAAAAACATTCCAAAAGATAATGTAGATAATGTTCCCAGGGTGTCCACTGAATCTTTCAG
CTCCAGGACAGTGACACAAAATCCTCAGCAGCAAAAGCTGGTCAAACCAACACACAATATATCATGCCAGAGTAATTCCAGGTCTTCGGC
ACCCATGGGCATCTATCAAAAGCAAAATCTGACAAAAATACCTCCCAGGGGCAAGTCTTCACCTCAGAAATCAAAACTAATGGAGCCCGA
AGCCACCACACTACTCCCTTCATCTGGCCTGGTGACTCTTGAAAAATCACCAGCCTTAGCTCCTGGGAAACTCTCACGATTCATGAAGAC
TGAGAGCTCAGGGCCCCTCTTTGAATTACGATCAGATCCACACATTCCAAAACATTCCGCCCAACTTCCGCACAGCTCCAGGATGCCCAG
CAGGAGGGACTGGGTCCAGTGCCCCAAGAGTCAGACTCCAGGGTCACGGTCAAGGCCTGCCATTGAGTCTAGTGACAGTGGAGAGCCCCC
CACGAGGGATGAACACTGTGGCTCTGGGCCGGAGGCAGGGGTGAAATCCCCTTCCCCTCCGCCCCCTCCAGGCAGGTCCGTCTCCCTGCT
GGCCAGGCCCAGCTATGACTATTCACCAGCACCTTCATCCACCAAGTCCGAAACCAGGGTCCCCAGTGAAACAGCAAGGACCCCATTCAA
ATCCCCGCTGCTGAAAGGAATTTCTGCTCCAGTTATTTCTTCTAATCCGGCCACGACAGAAGTGCAGAGGAAGAAACCTTCTGTGGCCTT
CAAAAAGCCTATCTTCACTCACCCTATGCCCTCCCCAGAAGCAGTCATTCAAACCCGATGCCCTGCTCATGCCCCCTCCAGCTCCTTCAC
CGTAATGGCTCTGGGGCCTCCAAAGGTCTCTCCGAAGAGAGGTGTCCCCAAAACCTCTCCTCGCCAAACACTTGGGACCCCACAAAGGGA
CATAGGATTACAGACTCCCAGGATCTCTCCTTCAACCCATGAGCCACTGGAAATGACGTCCTCCAAAAGTGTATCTCCAGGGAGAAAAGG
ACAATTGAATGATAGCGCCTCCACACCCCCCAAGCCTTCCTTCTTAGGGGTAAATGAGTCACCATCATCTCAGGTCAGCAGTTCCTCATC
ATCCTCATCACCCGCCAAAAGCCATAACAGCCCTCATGGTTGTCAAAGTGCTCATGAGAAAGGACTGAAAACTCGCCTTCCAGTGGGACT
CAAAGTGCTCATGAAGTCTCCCCAGCTGCTCAGGAAAAGTTCCACCGTGCCAGGGAAACATGAAAAAGACAGTTTAAATGAAGCCTCCAA
AAGTTCCGTGGCTGTGAACAAGTCTAAGCCAGAGGACTCCAAGAATCCAGCAAGCATGGAGATCACAGCGGGTGAAAGAAATGTGACCCT
ACCGGATTCACAAGCACAGGGCAGTTTAGCTGATGGGCTTCCCCTGGAAACAGCACTACAAGAGCCATTGGAAAGTAGCATCCCTGGGAG
TGATGGAAGGGATGGGGTAGATAATAGATCCATGAGAAGATCCCTTTCCTCCAGCAAACCACACCTAAAACCAGCTCTGGGTATGAATGG
CGCCAAAGCCCGCAGCCACAGCTTCAGTACACACTCAGGAGACAAGCCTTCTACGCCCCCCATCGAAGGGTCAGGCAAAGTCCGCACTCA
GATCATTACCAATACCGCCGAGAGAGGCAATTCTCTTACCCGGCAGAACTCTTCCACGGAAAGCTCTCCCAACAAGGCCCCTTCTGCTCC
CATGTTGGAGAGTCTCCCCAGTGTTGGGAGGCCCTCGGGGCACCCCTCCTCCGGGAAGGGCTCCCTGGGGAGCTCAGGCAGCTTCAGCAG
TCAGCATGGGAGCCCAAGTAAGTTGCCTTTGAGGATCCCTCCAAAGTCTGAGGGACTCCTCATCCCACCTGGAAAGGAAGACCAGCAGGC
CTTCACCCAGGGAGAGTGCCCCAGTGCCAATGTGGCTGTACTTGGGGAACCAGGCAGTGACCGCCGCAGTTGCCCACCCACCCCAACAGA
CTGCCCTGAAGCCCTGCAGAGCCCAGGGAGGACTCAGCATCCAAGCACTTTTGAAACAAGCAGTACATCCAAGCTAGAAACTTCTGGAAG
GCATCCAGATGCCTCTGCAACCGCGACTGATGCTGTGAGTTCAGAAGCCCCCCTCTCACCCACAATCGAAGAAAAGGTCATGTTGTGCAT
TCAGGAAAATGTGGAAAAGGGCCAAGTGCAAACAAAGCCCACCTCTGTGGAAGCAAAGCAGAAGCCTGGGCCTTCTTTTGCCAGCTGGTT
TGGTTTTCGGAAGAGTAGACTTCCAGCTCTGAGTAGCAGGAAAATGGACATCTCCAAAACCAAAGTAGAAAAGAAAGATGCAAAAGTCTT
GGGGTTTGGAAACAGACAACTAAAATCAGAAAGAAAAAAAGAGAAAAAGAAGCCTGAACTACAGTGTGAGACAGAAAATGAGCTTATCAA
GGACACCAAGTCAGCAGATAATCCAGATGGCGGTTTACAAAGCAAAAATAATCGGAGAACACCACAAGACATTTACAACCAACTGAAGAT
TGAACCAAGGAATAGACACAGCCCTGTTGCATGTTCAACGAAAGACACCTTCATGACGGAACTCTTGAACAGAGTTGATAAGAAAGCAGC
TCCACAGACAGAAAGTGGATCAAGTAATGCTTCCTGCAGGAATGTGTTAAAGGGCAGTTCTCAGGGCTCCTGTCTCATCGGCAGCTCTAT
CAGTACTCAAGGAAACCACAAGAAAAACATGAAAATCAAAGCCGATATGGAAGTACCAAAAGACTCCCTGGTAAAAGAGGCAAATGAAAA
CTTGCAAGAGGATGAAGACGATGCAGTTGCAGATTCTGTATTTCAGAGCCACATCATAGAATCCAACTGCCAGATGAGAACATTGGACAG
TGGGATCGGAACCTTTCCACTCCCAGACTCGGGAAATCGCTCGACAGGACGCTACCTATGCCAGCCAGACTCCCCAGAGGACGCTGAGCC
TCTCCTGCCTCTCCAGTCAGCCCTTTCTGCAGTTTCTTCCATGAGAGCCCAAACCCTTGAACGTGAAGTGCCTTCCTCCACAGACGGCCA
GCGCCCTGCAGATAGCGCCATTGTTCATTCCACATCCGACCCCATCATGACCGCCAGAGGGATGAGGCCTCTTCAGAGCCGCCTCCCCAA
ACCAGCTTCCTCAGGAAAAGTCAGTTCCCAAAAGCAGAATGAAGCAGAGCCAAGGCCTCAGACATGCTCATCATTCGGATATGCTGAAGA
CCCAATGGCAAGCCAGCCGCTTCCAGACTGGGGGAGTGAAGTTGCTGCCACCGGGACCCAGGACAAGGCACCCAGAATGTGTACGTACTC
TGCCAGCGGTGGCAGTAATAGTGACAGTGACCTGGACTATGGAGATAATGGTTTTGGAGCTGGAAGGGGACAGTTAGTGAAAGCACTGAA
GAGCGCTGCCCCAGAAATTGAGACAACTTGAAGAAACAAAAGACGATCCCGAGAATAGATTATCGAAAATTTCCCTAGAGTCATTCAATA
AATTTAACAGCAATACTGTGATTTTATTAGAAAAAGAGAAGAACTCTCTGAACAAGGTTGAAGGACAGAAGGAAGAAAAAGAAAAAAATG
AAGAGACATCTTTGAGTAGTTCAGATAGGCCTGGGGTAGACAACTTGGAATCTTTGAGTGATTCTTTATATGATAGCTTCTCTTCCTGTG
CCAGTCAAGGTTCAAATGATGTATAAAGGACATCTCTTCCCTTAGTGAGCTGGGACTGGAGCGCTTAAGAAATGATGGGTGGGGGGTGGG
GGGTGCACCGCTTGATAGAGATAACAATAAACTATTGCAGTACCAGAGCCTTCCTTGTCAAATTCACAGCAGGCAACCCACCAGAGCTTA
TTTCTCTGACAGGGCAATAAAGATAGACTCCATTTATTGTGTTTCAAGAGGATTAAGCGTAAACACATCTATGATACAGAATCCTTAATT
TTGCACTTTTTTTGAATATTTGTACAGAAGTTGTAAATTTTTTGGAAGAGAAATTATATTTGTAGCAAAAAAAGACAGCAATAAATGGAA
TCAGTGCCATGCTCTTGAAATAATGTACTAAGTCTTAGAAGTTGATGATAATATATATTTTTTAAAATCCCAACTGAAGTTTTTGTGAAG
TTCGTTGTCCTGGTCCTCAAATTGTTTGTGGGTACACTCTGTAAACCTACAACAGGGCCTGCCAAAAAATCGGAGGGTTCCTCCTCATCT
CCATCTCACAAATCTCAATTTGATGGAAATGTTCATTTTAGTGTAATTTCAGATTCGTTGCCAGAGATTCAGGTGATAGTAATAAGTGTC
ATTCTGCTTCTGCTGAAAAATGAAAAGGGTCCTGAAGTGTGGACACTGATTGGGAGTGTGACATTGTATCAGAAATGACCGAATTCTATT
CCCAATACCAGTTTTTCCTTCCAGACATTTCTTTAGATTGTCTTTTACTTAGTGCTTCTCTATGATCCTGAATATTATTTGATTTTTATC
TTCTTGCTCTTTTTATTAAAATCTGGGCACTCTAAAAATGAAAACAAATTTCTATTTGCAATGTTCACTTTTAAAAATAAAATTAATGGT
GCTACGAAGAATTCTTTTTAATATCCTTTTTTTTCTACAAAGACTGTTTATATGTAAGGATAAATTCTATTTTAAAGGTTATGTGTATTT
TTTCTAGATGTGAACTATTTATAATTACTTATGTACAGGAGCTTGTAAACTAGGCCCAATAGAAATATTTTTAGGATCTATATGGCTACT
TTAGCACATAATTGTTTCTTTAAAGAGTATTGTATGATCAGTGTTATTTGGTTAATTTGTGCAATTTGTTTTATTTTATCTTAAATGAAA

>61909_61909_4_OSMR-NCKAP5_OSMR_chr5_38886292_ENST00000502536_NCKAP5_chr2_133554302_ENST00000409261_length(amino acids)=1643AA_BP=3
MPIKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWH
DGKNLRKRQSSQNWDKRLSIDSSLPSGFASPTNELPPTRIKESHILEGLRKLQKRKVLLEPPSVITKWGYKDCMNSNEGIYSPGIKSSSL
KEYPPCKTADLGSPCKEPHKTFVYDLDSHVDADDDPSTLALLQAVPNQSCRPHGSKLTHSVSDSLFGWETNRKHFLEGTSSVYPKERPEK
LTSCASSCPLEMKLCPSVQTPQVQRERGPQGQGHGRMALNLQLSDTDDNETFDELHIESSDEKSPSDVSLAADTDKSVENLDVLVGFGKS
LCGSPEEEEKQVPIPSETRPKTFSFIKQQRVVKRTSSEECVTVIFDAEDGEPIEFSSHQTGVVTVTRNEISINSTPAGPKAEHTELLPQG
IACLQPRAAARDYTFFKRSEEDTEKNIPKDNVDNVPRVSTESFSSRTVTQNPQQQKLVKPTHNISCQSNSRSSAPMGIYQKQNLTKIPPR
GKSSPQKSKLMEPEATTLLPSSGLVTLEKSPALAPGKLSRFMKTESSGPLFELRSDPHIPKHSAQLPHSSRMPSRRDWVQCPKSQTPGSR
SRPAIESSDSGEPPTRDEHCGSGPEAGVKSPSPPPPPGRSVSLLARPSYDYSPAPSSTKSETRVPSETARTPFKSPLLKGISAPVISSNP
ATTEVQRKKPSVAFKKPIFTHPMPSPEAVIQTRCPAHAPSSSFTVMALGPPKVSPKRGVPKTSPRQTLGTPQRDIGLQTPRISPSTHEPL
EMTSSKSVSPGRKGQLNDSASTPPKPSFLGVNESPSSQVSSSSSSSSPAKSHNSPHGCQSAHEKGLKTRLPVGLKVLMKSPQLLRKSSTV
PGKHEKDSLNEASKSSVAVNKSKPEDSKNPASMEITAGERNVTLPDSQAQGSLADGLPLETALQEPLESSIPGSDGRDGVDNRSMRRSLS
SSKPHLKPALGMNGAKARSHSFSTHSGDKPSTPPIEGSGKVRTQIITNTAERGNSLTRQNSSTESSPNKAPSAPMLESLPSVGRPSGHPS
SGKGSLGSSGSFSSQHGSPSKLPLRIPPKSEGLLIPPGKEDQQAFTQGECPSANVAVLGEPGSDRRSCPPTPTDCPEALQSPGRTQHPST
FETSSTSKLETSGRHPDASATATDAVSSEAPLSPTIEEKVMLCIQENVEKGQVQTKPTSVEAKQKPGPSFASWFGFRKSRLPALSSRKMD
ISKTKVEKKDAKVLGFGNRQLKSERKKEKKKPELQCETENELIKDTKSADNPDGGLQSKNNRRTPQDIYNQLKIEPRNRHSPVACSTKDT
FMTELLNRVDKKAAPQTESGSSNASCRNVLKGSSQGSCLIGSSISTQGNHKKNMKIKADMEVPKDSLVKEANENLQEDEDDAVADSVFQS
HIIESNCQMRTLDSGIGTFPLPDSGNRSTGRYLCQPDSPEDAEPLLPLQSALSAVSSMRAQTLEREVPSSTDGQRPADSAIVHSTSDPIM
TARGMRPLQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPMASQPLPDWGSEVAATGTQDKAPRMCTYSASGGSNSDSDLDYGDN

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Fusion Gene PPI Analysis for OSMR-NCKAP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OSMR-NCKAP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OSMR-NCKAP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource