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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OTUB1-RPS6KA4 (FusionGDB2 ID:61954)

Fusion Gene Summary for OTUB1-RPS6KA4

check button Fusion gene summary
Fusion gene informationFusion gene name: OTUB1-RPS6KA4
Fusion gene ID: 61954
HgeneTgene
Gene symbol

OTUB1

RPS6KA4

Gene ID

55611

8986

Gene nameOTU deubiquitinase, ubiquitin aldehyde binding 1ribosomal protein S6 kinase A4
SynonymsHSPC263|OTB1|OTU1MSK2|RSK-B|S6K-alpha-4
Cytomap

11q13.1

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionubiquitin thioesterase OTUB1OTU domain, ubiquitin aldehyde binding 1OTU domain-containing ubiquitin aldehyde-binding protein 1OTU-domain Ubal-binding 1deubiquitinating enzyme OTUB1otubain-1ubiquitin-specific protease otubain 1ubiquitin-specific-proribosomal protein S6 kinase alpha-490 kDa ribosomal protein S6 kinase 4mitogen- and stress-activated protein kinase 2nuclear mitogen- and stress-activated protein kinase 2ribosomal protein S6 kinase, 90kDa, polypeptide 4ribosomal protein kinase B
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000536443, ENST00000422031, 
ENST00000428192, ENST00000535715, 
ENST00000538426, ENST00000543004, 
ENST00000543988, ENST00000541478, 
ENST00000294261, ENST00000334205, 
ENST00000528057, 
Fusion gene scores* DoF score10 X 8 X 7=5602 X 2 X 2=8
# samples 103
** MAII scorelog2(10/560*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: OTUB1 [Title/Abstract] AND RPS6KA4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOTUB1(63756224)-RPS6KA4(64132773), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOTUB1

GO:0006974

cellular response to DNA damage stimulus

20725033

HgeneOTUB1

GO:0071108

protein K48-linked deubiquitination

18954305|19211026|23827681

HgeneOTUB1

GO:1901315

negative regulation of histone H2A K63-linked ubiquitination

20725033

TgeneRPS6KA4

GO:0006355

regulation of transcription, DNA-templated

9792677

TgeneRPS6KA4

GO:0006468

protein phosphorylation

9792677

TgeneRPS6KA4

GO:0035556

intracellular signal transduction

9792677


check buttonFusion gene breakpoints across OTUB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPS6KA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-5973-01AOTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
ChimerDB4HNSCTCGA-CV-5973OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+


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Fusion Gene ORF analysis for OTUB1-RPS6KA4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000536443ENST00000294261OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
3UTR-3CDSENST00000536443ENST00000334205OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
3UTR-3CDSENST00000536443ENST00000528057OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000422031ENST00000294261OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000422031ENST00000334205OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000422031ENST00000528057OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000428192ENST00000294261OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000428192ENST00000334205OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000428192ENST00000528057OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000535715ENST00000294261OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000535715ENST00000334205OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000535715ENST00000528057OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000538426ENST00000294261OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000538426ENST00000334205OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000538426ENST00000528057OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000543004ENST00000294261OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000543004ENST00000334205OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000543004ENST00000528057OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000543988ENST00000294261OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000543988ENST00000334205OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
In-frameENST00000543988ENST00000528057OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
intron-3CDSENST00000541478ENST00000294261OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
intron-3CDSENST00000541478ENST00000334205OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+
intron-3CDSENST00000541478ENST00000528057OTUB1chr11

63756224

+RPS6KA4chr11

64132773

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535715OTUB1chr1163756224+ENST00000528057RPS6KA4chr1164132773+27986714102062550
ENST00000535715OTUB1chr1163756224+ENST00000334205RPS6KA4chr1164132773+28196714102083557
ENST00000535715OTUB1chr1163756224+ENST00000294261RPS6KA4chr1164132773+20746714101339309
ENST00000422031OTUB1chr1163756224+ENST00000528057RPS6KA4chr1164132773+2669542111933640
ENST00000422031OTUB1chr1163756224+ENST00000334205RPS6KA4chr1164132773+2690542111954647
ENST00000422031OTUB1chr1163756224+ENST00000294261RPS6KA4chr1164132773+1945542111210399
ENST00000428192OTUB1chr1163756224+ENST00000528057RPS6KA4chr1164132773+2669542111933640
ENST00000428192OTUB1chr1163756224+ENST00000334205RPS6KA4chr1164132773+2690542111954647
ENST00000428192OTUB1chr1163756224+ENST00000294261RPS6KA4chr1164132773+1945542111210399
ENST00000538426OTUB1chr1163756224+ENST00000528057RPS6KA4chr1164132773+239026321654550
ENST00000538426OTUB1chr1163756224+ENST00000334205RPS6KA4chr1164132773+241126321675557
ENST00000538426OTUB1chr1163756224+ENST00000294261RPS6KA4chr1164132773+16662632931309
ENST00000543004OTUB1chr1163756224+ENST00000528057RPS6KA4chr1164132773+2384257111648545
ENST00000543004OTUB1chr1163756224+ENST00000334205RPS6KA4chr1164132773+2405257111669552
ENST00000543004OTUB1chr1163756224+ENST00000294261RPS6KA4chr1164132773+166025711925304
ENST00000543988OTUB1chr1163756224+ENST00000528057RPS6KA4chr1164132773+24853581601749529
ENST00000543988OTUB1chr1163756224+ENST00000334205RPS6KA4chr1164132773+25063581601770536
ENST00000543988OTUB1chr1163756224+ENST00000294261RPS6KA4chr1164132773+17613581601026288

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535715ENST00000528057OTUB1chr1163756224+RPS6KA4chr1164132773+0.0170126630.9829874
ENST00000535715ENST00000334205OTUB1chr1163756224+RPS6KA4chr1164132773+0.0169114880.98308855
ENST00000535715ENST00000294261OTUB1chr1163756224+RPS6KA4chr1164132773+0.0197677440.98023224
ENST00000422031ENST00000528057OTUB1chr1163756224+RPS6KA4chr1164132773+0.0404529940.95954704
ENST00000422031ENST00000334205OTUB1chr1163756224+RPS6KA4chr1164132773+0.038248920.96175104
ENST00000422031ENST00000294261OTUB1chr1163756224+RPS6KA4chr1164132773+0.0417621060.9582379
ENST00000428192ENST00000528057OTUB1chr1163756224+RPS6KA4chr1164132773+0.0404529940.95954704
ENST00000428192ENST00000334205OTUB1chr1163756224+RPS6KA4chr1164132773+0.038248920.96175104
ENST00000428192ENST00000294261OTUB1chr1163756224+RPS6KA4chr1164132773+0.0417621060.9582379
ENST00000538426ENST00000528057OTUB1chr1163756224+RPS6KA4chr1164132773+0.0155627770.9844372
ENST00000538426ENST00000334205OTUB1chr1163756224+RPS6KA4chr1164132773+0.0155747670.9844252
ENST00000538426ENST00000294261OTUB1chr1163756224+RPS6KA4chr1164132773+0.0200180620.9799819
ENST00000543004ENST00000528057OTUB1chr1163756224+RPS6KA4chr1164132773+0.0139477860.98605216
ENST00000543004ENST00000334205OTUB1chr1163756224+RPS6KA4chr1164132773+0.0151372240.98486274
ENST00000543004ENST00000294261OTUB1chr1163756224+RPS6KA4chr1164132773+0.0088936380.99110633
ENST00000543988ENST00000528057OTUB1chr1163756224+RPS6KA4chr1164132773+0.0143192260.9856808
ENST00000543988ENST00000334205OTUB1chr1163756224+RPS6KA4chr1164132773+0.0153068150.98469317
ENST00000543988ENST00000294261OTUB1chr1163756224+RPS6KA4chr1164132773+0.033466050.96653396

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Fusion Genomic Features for OTUB1-RPS6KA4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
OTUB1chr1163756224+RPS6KA4chr1164132772+2.00E-101
OTUB1chr1163756224+RPS6KA4chr1164132772+2.00E-101
OTUB1chr1163756224+RPS6KA4chr1164132772+2.00E-101
OTUB1chr1163756224+RPS6KA4chr1164132772+2.00E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for OTUB1-RPS6KA4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:63756224/chr11:64132773)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRPS6KA4chr11:63756224chr11:64132773ENST00000334205717302_371302773.0DomainAGC-kinase C-terminal
TgeneRPS6KA4chr11:63756224chr11:64132773ENST00000334205717411_674302773.0DomainProtein kinase 2
TgeneRPS6KA4chr11:63756224chr11:64132773ENST00000334205717417_425302773.0Nucleotide bindingATP
TgeneRPS6KA4chr11:63756224chr11:64132773ENST00000334205717725_772302773.0RegionNote=Required for nuclear targeting and association with MAPK14

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOTUB1chr11:63756224chr11:64132773ENST00000428192+4880_27173272.0DomainOTU
HgeneOTUB1chr11:63756224chr11:64132773ENST00000538426+3780_27173272.0DomainOTU
HgeneOTUB1chr11:63756224chr11:64132773ENST00000428192+48130_13873272.0RegionUbiquitin-conjugating enzyme E2 binding
HgeneOTUB1chr11:63756224chr11:64132773ENST00000428192+48169_17773272.0RegionUbiquitin-conjugating enzyme E2 binding
HgeneOTUB1chr11:63756224chr11:64132773ENST00000428192+48189_19573272.0RegionFree ubiquitin binding
HgeneOTUB1chr11:63756224chr11:64132773ENST00000428192+48206_21373272.0RegionUbiquitin-conjugating enzyme E2 binding
HgeneOTUB1chr11:63756224chr11:64132773ENST00000428192+48214_22173272.0RegionFree ubiquitin binding
HgeneOTUB1chr11:63756224chr11:64132773ENST00000428192+48245_25173272.0RegionFree ubiquitin binding
HgeneOTUB1chr11:63756224chr11:64132773ENST00000538426+37130_13873272.0RegionUbiquitin-conjugating enzyme E2 binding
HgeneOTUB1chr11:63756224chr11:64132773ENST00000538426+37169_17773272.0RegionUbiquitin-conjugating enzyme E2 binding
HgeneOTUB1chr11:63756224chr11:64132773ENST00000538426+37189_19573272.0RegionFree ubiquitin binding
HgeneOTUB1chr11:63756224chr11:64132773ENST00000538426+37206_21373272.0RegionUbiquitin-conjugating enzyme E2 binding
HgeneOTUB1chr11:63756224chr11:64132773ENST00000538426+37214_22173272.0RegionFree ubiquitin binding
HgeneOTUB1chr11:63756224chr11:64132773ENST00000538426+37245_25173272.0RegionFree ubiquitin binding
TgeneRPS6KA4chr11:63756224chr11:64132773ENST0000033420571733_301302773.0DomainProtein kinase 1
TgeneRPS6KA4chr11:63756224chr11:64132773ENST0000033420571739_47302773.0Nucleotide bindingATP


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Fusion Gene Sequence for OTUB1-RPS6KA4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61954_61954_1_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000422031_RPS6KA4_chr11_64132773_ENST00000294261_length(transcript)=1945nt_BP=542nt
GCTGCTCCGCACTGCAGCTATGGTCGCATGCAGTGCCTGCCGAAGCCCGCAGCAGGAATGCTGCCTTCGGTGATTTTAATTTCACTTTTC
TACTTCTCTCAATAACAAAATCCGCGTTTCAAACTCCAGGGAAAAGAAAACGGAATTGGCTCCAGGAGGATCTGCAATCACCACCGGGAA
CTTTGGGAGGCTGGGAAGATGGAGCCAAACCAATGTGTGGGGTGGAGGGCTGTTGCCAAGGCGGGGCAACGAGGAGGGGCTCGCTTCCGG
GAGGACGGCAATTGGCAACCCGGAAGCGGTCGGTAGTGCGGCGCTGTTTAAAGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGC
CGCTGGGCAGCGACTCCGAAGGTGTTAACTGTCTGGCCTATGATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTG
TGCAGAACCCTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCA
AGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTG
CGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTG
TGGCACCCTCCATTCTCTTTGACCACAACAACGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCT
GGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGG
GCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCT
CGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGC
GGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAG
GGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGC
CCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAG
AGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGG
GGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTA
AGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAAC
TGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGC
ATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCA
CCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCC

>61954_61954_1_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000422031_RPS6KA4_chr11_64132773_ENST00000294261_length(amino acids)=399AA_BP=1
MQLWSHAVPAEARSRNAAFGDFNFTFLLLSITKSAFQTPGKRKRNWLQEDLQSPPGTLGGWEDGAKPMCGVEGCCQGGATRRGSLPGGRQ
LATRKRSVVRRCLKMAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLD
WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAAEIMCKIREGRFSLDGEAWQGV
SEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQ

--------------------------------------------------------------
>61954_61954_2_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000422031_RPS6KA4_chr11_64132773_ENST00000334205_length(transcript)=2690nt_BP=542nt
GCTGCTCCGCACTGCAGCTATGGTCGCATGCAGTGCCTGCCGAAGCCCGCAGCAGGAATGCTGCCTTCGGTGATTTTAATTTCACTTTTC
TACTTCTCTCAATAACAAAATCCGCGTTTCAAACTCCAGGGAAAAGAAAACGGAATTGGCTCCAGGAGGATCTGCAATCACCACCGGGAA
CTTTGGGAGGCTGGGAAGATGGAGCCAAACCAATGTGTGGGGTGGAGGGCTGTTGCCAAGGCGGGGCAACGAGGAGGGGCTCGCTTCCGG
GAGGACGGCAATTGGCAACCCGGAAGCGGTCGGTAGTGCGGCGCTGTTTAAAGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGC
CGCTGGGCAGCGACTCCGAAGGTGTTAACTGTCTGGCCTATGATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTG
TGCAGAACCCTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCA
AGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTG
CGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTG
TGGCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACCGATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAG
CGGTGGCCAGGAGCGCTATGATGCAGGACTCGCCCTTCTTCCAGCAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCT
TTTCTGTGTGTCGCCGCTGCCGCCAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGC
GCGAAGTGGCTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTGGTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGG
TCCTGGAGCTGCTGCGGGGCGGGGAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCA
GCCTCGTGTCGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACA
CGCCCGGGGCCCCGGTGAAAATCATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCA
CGCTGCAGTACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGA
TGCTGTCGGGGCAGGTCCCCTTCCAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGC
GCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGC
GGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCG
AGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCG
TGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGG
GCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCC
TCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTC
CTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGG
GGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAG
GAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCG
TTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAG
AGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTC
CTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGG

>61954_61954_2_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000422031_RPS6KA4_chr11_64132773_ENST00000334205_length(amino acids)=647AA_BP=1
MQLWSHAVPAEARSRNAAFGDFNFTFLLLSITKSAFQTPGKRKRNWLQEDLQSPPGTLGGWEDGAKPMCGVEGCCQGGATRRGSLPGGRQ
LATRKRSVVRRCLKMAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLD
WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVAR
SAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLEL
LRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQY
AAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKL
EGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAP

--------------------------------------------------------------
>61954_61954_3_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000422031_RPS6KA4_chr11_64132773_ENST00000528057_length(transcript)=2669nt_BP=542nt
GCTGCTCCGCACTGCAGCTATGGTCGCATGCAGTGCCTGCCGAAGCCCGCAGCAGGAATGCTGCCTTCGGTGATTTTAATTTCACTTTTC
TACTTCTCTCAATAACAAAATCCGCGTTTCAAACTCCAGGGAAAAGAAAACGGAATTGGCTCCAGGAGGATCTGCAATCACCACCGGGAA
CTTTGGGAGGCTGGGAAGATGGAGCCAAACCAATGTGTGGGGTGGAGGGCTGTTGCCAAGGCGGGGCAACGAGGAGGGGCTCGCTTCCGG
GAGGACGGCAATTGGCAACCCGGAAGCGGTCGGTAGTGCGGCGCTGTTTAAAGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGC
CGCTGGGCAGCGACTCCGAAGGTGTTAACTGTCTGGCCTATGATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTG
TGCAGAACCCTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCA
AGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTG
CGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTG
TGGCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACCGATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAG
CGGTGGCCAGGAGCGCTATGATGCAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCCGCTGCC
GCCAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCC
TGTGCCAGTCACACCCCAACGTGGTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTGCGGGGCG
GGGAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCT
TCATGCACGAGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCGGTGAAAA
TCATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCG
AGCTGCTGGCGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAGGTCCCCT
TCCAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGG
CCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGC
GGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGC
GCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCA
AGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCA
AAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGG
AGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGA
CAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTT
TGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTT
CTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTC
AACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGA
AGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTC
TCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAG

>61954_61954_3_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000422031_RPS6KA4_chr11_64132773_ENST00000528057_length(amino acids)=640AA_BP=1
MQLWSHAVPAEARSRNAAFGDFNFTFLLLSITKSAFQTPGKRKRNWLQEDLQSPPGTLGGWEDGAKPMCGVEGCCQGGATRRGSLPGGRQ
LATRKRSVVRRCLKMAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLD
WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVAR
SAMMQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELL
EHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLA
QQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSS
WLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAP

--------------------------------------------------------------
>61954_61954_4_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000428192_RPS6KA4_chr11_64132773_ENST00000294261_length(transcript)=1945nt_BP=542nt
GCTGCTCCGCACTGCAGCTATGGTCGCATGCAGTGCCTGCCGAAGCCCGCAGCAGGAATGCTGCCTTCGGTGATTTTAATTTCACTTTTC
TACTTCTCTCAATAACAAAATCCGCGTTTCAAACTCCAGGGAAAAGAAAACGGAATTGGCTCCAGGAGGATCTGCAATCACCACCGGGAA
CTTTGGGAGGCTGGGAAGATGGAGCCAAACCAATGTGTGGGGTGGAGGGCTGTTGCCAAGGCGGGGCAACGAGGAGGGGCTCGCTTCCGG
GAGGACGGCAATTGGCAACCCGGAAGCGGTCGGTAGTGCGGCGCTGTTTAAAGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGC
CGCTGGGCAGCGACTCCGAAGGTGTTAACTGTCTGGCCTATGATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTG
TGCAGAACCCTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCA
AGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTG
CGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTG
TGGCACCCTCCATTCTCTTTGACCACAACAACGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCT
GGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGG
GCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCT
CGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGC
GGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAG
GGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGC
CCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAG
AGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGG
GGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTA
AGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAAC
TGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGC
ATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCA
CCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCC

>61954_61954_4_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000428192_RPS6KA4_chr11_64132773_ENST00000294261_length(amino acids)=399AA_BP=1
MQLWSHAVPAEARSRNAAFGDFNFTFLLLSITKSAFQTPGKRKRNWLQEDLQSPPGTLGGWEDGAKPMCGVEGCCQGGATRRGSLPGGRQ
LATRKRSVVRRCLKMAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLD
WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAAEIMCKIREGRFSLDGEAWQGV
SEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQ

--------------------------------------------------------------
>61954_61954_5_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000428192_RPS6KA4_chr11_64132773_ENST00000334205_length(transcript)=2690nt_BP=542nt
GCTGCTCCGCACTGCAGCTATGGTCGCATGCAGTGCCTGCCGAAGCCCGCAGCAGGAATGCTGCCTTCGGTGATTTTAATTTCACTTTTC
TACTTCTCTCAATAACAAAATCCGCGTTTCAAACTCCAGGGAAAAGAAAACGGAATTGGCTCCAGGAGGATCTGCAATCACCACCGGGAA
CTTTGGGAGGCTGGGAAGATGGAGCCAAACCAATGTGTGGGGTGGAGGGCTGTTGCCAAGGCGGGGCAACGAGGAGGGGCTCGCTTCCGG
GAGGACGGCAATTGGCAACCCGGAAGCGGTCGGTAGTGCGGCGCTGTTTAAAGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGC
CGCTGGGCAGCGACTCCGAAGGTGTTAACTGTCTGGCCTATGATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTG
TGCAGAACCCTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCA
AGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTG
CGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTG
TGGCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACCGATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAG
CGGTGGCCAGGAGCGCTATGATGCAGGACTCGCCCTTCTTCCAGCAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCT
TTTCTGTGTGTCGCCGCTGCCGCCAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGC
GCGAAGTGGCTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTGGTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGG
TCCTGGAGCTGCTGCGGGGCGGGGAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCA
GCCTCGTGTCGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACA
CGCCCGGGGCCCCGGTGAAAATCATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCA
CGCTGCAGTACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGA
TGCTGTCGGGGCAGGTCCCCTTCCAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGC
GCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGC
GGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCG
AGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCG
TGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGG
GCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCC
TCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTC
CTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGG
GGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAG
GAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCG
TTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAG
AGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTC
CTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGG

>61954_61954_5_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000428192_RPS6KA4_chr11_64132773_ENST00000334205_length(amino acids)=647AA_BP=1
MQLWSHAVPAEARSRNAAFGDFNFTFLLLSITKSAFQTPGKRKRNWLQEDLQSPPGTLGGWEDGAKPMCGVEGCCQGGATRRGSLPGGRQ
LATRKRSVVRRCLKMAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLD
WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVAR
SAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLEL
LRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQY
AAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKL
EGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAP

--------------------------------------------------------------
>61954_61954_6_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000428192_RPS6KA4_chr11_64132773_ENST00000528057_length(transcript)=2669nt_BP=542nt
GCTGCTCCGCACTGCAGCTATGGTCGCATGCAGTGCCTGCCGAAGCCCGCAGCAGGAATGCTGCCTTCGGTGATTTTAATTTCACTTTTC
TACTTCTCTCAATAACAAAATCCGCGTTTCAAACTCCAGGGAAAAGAAAACGGAATTGGCTCCAGGAGGATCTGCAATCACCACCGGGAA
CTTTGGGAGGCTGGGAAGATGGAGCCAAACCAATGTGTGGGGTGGAGGGCTGTTGCCAAGGCGGGGCAACGAGGAGGGGCTCGCTTCCGG
GAGGACGGCAATTGGCAACCCGGAAGCGGTCGGTAGTGCGGCGCTGTTTAAAGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGC
CGCTGGGCAGCGACTCCGAAGGTGTTAACTGTCTGGCCTATGATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTG
TGCAGAACCCTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCA
AGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTG
CGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTG
TGGCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACCGATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAG
CGGTGGCCAGGAGCGCTATGATGCAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCCGCTGCC
GCCAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCC
TGTGCCAGTCACACCCCAACGTGGTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTGCGGGGCG
GGGAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCT
TCATGCACGAGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCGGTGAAAA
TCATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCG
AGCTGCTGGCGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAGGTCCCCT
TCCAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGG
CCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGC
GGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGC
GCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCA
AGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCA
AAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGG
AGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGA
CAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTT
TGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTT
CTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTC
AACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGA
AGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTC
TCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAG

>61954_61954_6_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000428192_RPS6KA4_chr11_64132773_ENST00000528057_length(amino acids)=640AA_BP=1
MQLWSHAVPAEARSRNAAFGDFNFTFLLLSITKSAFQTPGKRKRNWLQEDLQSPPGTLGGWEDGAKPMCGVEGCCQGGATRRGSLPGGRQ
LATRKRSVVRRCLKMAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLD
WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVAR
SAMMQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELL
EHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLA
QQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSS
WLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAP

--------------------------------------------------------------
>61954_61954_7_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000535715_RPS6KA4_chr11_64132773_ENST00000294261_length(transcript)=2074nt_BP=671nt
GTCAGATGCTGCTCCGCACTGCAGCTATGGTCGCATGCAGTGCCTGCCGAAGCCCGCAGCAGGAATGCTGCCTTCGGTGATTTTAATTTC
ACTTTTCTACTTCTCTCAATAACAAAATCCGCGTTTCAAACTCCAGGGAAAAGAAAACGGAATTGGCTCCAGGAGGATCTGCAATCACCA
CCGGGAACTTTGGGAGGCTGGGAAGATGGAGCCAAACCAATGTGTGGGGTGGAGGTGCGGATCTGGGGCGGCCGGCCTCTCCTACAGGTC
TCAGGTCCGCAGGCCTGGCGTGCCAGCACCTGCCACGGGACTGGAAGCCCATTCCTTGACAACGCCTAAGGGGATCCCGTTGCTAGGGCT
GTTGCCAAGGCGGGGCAACGAGGAGGGGCTCGCTTCCGGGAGGACGGCAATTGGCAACCCGGAAGCGGTCGGTAGTGCGGCGCTGTTTAA
AGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGCCGCTGGGCAGCGACTCCGAAGGTGTTAACTGTCTGGCCTATGATGAAGCCA
TCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTGTGCAGAACCCTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGG
AGTATGCTGAAGATGACAACATCTATCAACAGAAGATCAAGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCC
GGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCC
CACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTCTCTTTGACCACAACAACGCGGCCGAGATCATGTGCA
AAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCG
TGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGA
CGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCT
TCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTG
CACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCAC
TGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGA
CTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAG
TTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGG
GGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTC
TCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTG
GGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAA
GGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTG
GGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCTGTGCCTTTGACTTTAAAATAAAAGTCCACCCAGTGCTGTGTG

>61954_61954_7_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000535715_RPS6KA4_chr11_64132773_ENST00000294261_length(amino acids)=309AA_BP=1
MATRKRSVVRRCLKMAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLD
WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAAEIMCKIREGRFSLDGEAWQGV
SEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQ

--------------------------------------------------------------
>61954_61954_8_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000535715_RPS6KA4_chr11_64132773_ENST00000334205_length(transcript)=2819nt_BP=671nt
GTCAGATGCTGCTCCGCACTGCAGCTATGGTCGCATGCAGTGCCTGCCGAAGCCCGCAGCAGGAATGCTGCCTTCGGTGATTTTAATTTC
ACTTTTCTACTTCTCTCAATAACAAAATCCGCGTTTCAAACTCCAGGGAAAAGAAAACGGAATTGGCTCCAGGAGGATCTGCAATCACCA
CCGGGAACTTTGGGAGGCTGGGAAGATGGAGCCAAACCAATGTGTGGGGTGGAGGTGCGGATCTGGGGCGGCCGGCCTCTCCTACAGGTC
TCAGGTCCGCAGGCCTGGCGTGCCAGCACCTGCCACGGGACTGGAAGCCCATTCCTTGACAACGCCTAAGGGGATCCCGTTGCTAGGGCT
GTTGCCAAGGCGGGGCAACGAGGAGGGGCTCGCTTCCGGGAGGACGGCAATTGGCAACCCGGAAGCGGTCGGTAGTGCGGCGCTGTTTAA
AGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGCCGCTGGGCAGCGACTCCGAAGGTGTTAACTGTCTGGCCTATGATGAAGCCA
TCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTGTGCAGAACCCTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGG
AGTATGCTGAAGATGACAACATCTATCAACAGAAGATCAAGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCC
GGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCC
CACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACCGATGGGC
TGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGTGGCCAGGAGCGCTATGATGCAGGACTCGCCCTTCTTCCAGCAGTACG
AGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCCGCTGCCGCCAGCGCCAGAGCGGCCAGGAGTTCGCAG
TCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTGGTGAATC
TGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTGCGGGGCGGGGAGCTGCTGGAGCACATCCGCAAGAAGC
GGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTGGTGCACC
GCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCGGTGAAAATCATCGACTTCGGGTTCGCGCGGTTGCGGC
CGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTACGACGAGT
CCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAGGTCCCCTTCCAGGGGGCCTCTGGCCAGGGCGGGCAGA
GCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGG
AGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCG
CGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCAT
TCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCA
CCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAACGGCCCCC
TGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCCTCTGCCT
GCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAGCAGAGAA
TTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACACTGCCTCT
TCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCTAACTCCT
AAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCTGTGCAAT
TACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGTCATCTGC
TTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGCACAGCTA
CTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCTGTGCCTTTGACTTTAAAA

>61954_61954_8_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000535715_RPS6KA4_chr11_64132773_ENST00000334205_length(amino acids)=557AA_BP=1
MATRKRSVVRRCLKMAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLD
WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVAR
SAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLEL
LRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQY
AAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKL
EGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAP

--------------------------------------------------------------
>61954_61954_9_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000535715_RPS6KA4_chr11_64132773_ENST00000528057_length(transcript)=2798nt_BP=671nt
GTCAGATGCTGCTCCGCACTGCAGCTATGGTCGCATGCAGTGCCTGCCGAAGCCCGCAGCAGGAATGCTGCCTTCGGTGATTTTAATTTC
ACTTTTCTACTTCTCTCAATAACAAAATCCGCGTTTCAAACTCCAGGGAAAAGAAAACGGAATTGGCTCCAGGAGGATCTGCAATCACCA
CCGGGAACTTTGGGAGGCTGGGAAGATGGAGCCAAACCAATGTGTGGGGTGGAGGTGCGGATCTGGGGCGGCCGGCCTCTCCTACAGGTC
TCAGGTCCGCAGGCCTGGCGTGCCAGCACCTGCCACGGGACTGGAAGCCCATTCCTTGACAACGCCTAAGGGGATCCCGTTGCTAGGGCT
GTTGCCAAGGCGGGGCAACGAGGAGGGGCTCGCTTCCGGGAGGACGGCAATTGGCAACCCGGAAGCGGTCGGTAGTGCGGCGCTGTTTAA
AGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGCCGCTGGGCAGCGACTCCGAAGGTGTTAACTGTCTGGCCTATGATGAAGCCA
TCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTGTGCAGAACCCTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGG
AGTATGCTGAAGATGACAACATCTATCAACAGAAGATCAAGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCC
GGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCC
CACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACCGATGGGC
TGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGTGGCCAGGAGCGCTATGATGCAGTACGAGCTGGACCTGCGGGAGCCTG
CGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCCGCTGCCGCCAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGC
TGGAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTGGTGAATCTGCACGAGGTGCATCACGACC
AGCTGCACACGTACCTGGTCCTGGAGCTGCTGCGGGGCGGGGAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAG
CAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCGGAGAACA
TCCTGTACGCCGACGACACGCCCGGGGCCCCGGTGAAAATCATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCA
TGCAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGGAGCCTGG
GCGTCATTCTGTACATGATGCTGTCGGGGCAGGTCCCCTTCCAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGT
GCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGA
CCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCC
GGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGG
GCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCC
CTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCAC
CACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAG
GGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATA
GAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCA
GGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTG
TTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTG
TTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAG
GAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCC
TTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCTGTGCCTTTGACTTTAAAATAAAAGTCCACCCAGTGCTGT

>61954_61954_9_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000535715_RPS6KA4_chr11_64132773_ENST00000528057_length(amino acids)=550AA_BP=1
MATRKRSVVRRCLKMAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLD
WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVAR
SAMMQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELL
EHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLA
QQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSS
WLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAP

--------------------------------------------------------------
>61954_61954_10_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000538426_RPS6KA4_chr11_64132773_ENST00000294261_length(transcript)=1666nt_BP=263nt
AATTGGCAACCCGGAAGCGGTCGGTAGTGCGGCGCTGTTTAAAGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGCCGCTGGGCA
GCGACTCCGAAGGTGTTAACTGTCTGGCCTATGATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTGTGCAGAACC
CTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCAAGGGCCTCG
ATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAAT
TCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCT
CCATTCTCTTTGACCACAACAACGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTG
TATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGT
GGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCA
ACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGC
AGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCC
GCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCAC
TCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGT
ATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTC
TCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAG
TTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTT
ATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCC
TCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCT
TCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCT

>61954_61954_10_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000538426_RPS6KA4_chr11_64132773_ENST00000294261_length(amino acids)=309AA_BP=0
LATRKRSVVRRCLKMAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLD
WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAAEIMCKIREGRFSLDGEAWQGV
SEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQ

--------------------------------------------------------------
>61954_61954_11_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000538426_RPS6KA4_chr11_64132773_ENST00000334205_length(transcript)=2411nt_BP=263nt
AATTGGCAACCCGGAAGCGGTCGGTAGTGCGGCGCTGTTTAAAGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGCCGCTGGGCA
GCGACTCCGAAGGTGTTAACTGTCTGGCCTATGATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTGTGCAGAACC
CTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCAAGGGCCTCG
ATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAAT
TCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCT
CCATTCTCTTTGACCACAACAACGCGGTGATGACCGATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGTGGCCA
GGAGCGCTATGATGCAGGACTCGCCCTTCTTCCAGCAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGT
GTCGCCGCTGCCGCCAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGG
CTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTGGTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCTGGAGC
TGCTGCGGGGCGGGGAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGT
CGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCCCGGGG
CCCCGGTGAAAATCATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCACGCTGCAGT
ACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCTGTCGG
GGCAGGTCCCCTTCCAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCC
TTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGC
TCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTG
GGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATG
CACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCC
CCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGG
CTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCAC
CCCACTCCCAGACAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTG
GGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCC
CCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGA
GGGGCACCCCTCAACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGG
GGGACCCTCTGAAGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAG
GAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGG

>61954_61954_11_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000538426_RPS6KA4_chr11_64132773_ENST00000334205_length(amino acids)=557AA_BP=0
LATRKRSVVRRCLKMAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLD
WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVAR
SAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLEL
LRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQY
AAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKL
EGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAP

--------------------------------------------------------------
>61954_61954_12_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000538426_RPS6KA4_chr11_64132773_ENST00000528057_length(transcript)=2390nt_BP=263nt
AATTGGCAACCCGGAAGCGGTCGGTAGTGCGGCGCTGTTTAAAGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGCCGCTGGGCA
GCGACTCCGAAGGTGTTAACTGTCTGGCCTATGATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTGTGCAGAACC
CTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCAAGGGCCTCG
ATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAAT
TCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCT
CCATTCTCTTTGACCACAACAACGCGGTGATGACCGATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGTGGCCA
GGAGCGCTATGATGCAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCCGCTGCCGCCAGCGCC
AGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCCTGTGCCAGT
CACACCCCAACGTGGTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTGCGGGGCGGGGAGCTGC
TGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCTTCATGCACG
AGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCGGTGAAAATCATCGACT
TCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCGAGCTGCTGG
CGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAGGTCCCCTTCCAGGGGG
CCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGG
GTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCT
CGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTC
TCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGA
AGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCC
CCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCT
CACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGA
AGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCC
CTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACT
GAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCAC
TTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCT
GCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACC
CCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAG

>61954_61954_12_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000538426_RPS6KA4_chr11_64132773_ENST00000528057_length(amino acids)=550AA_BP=0
LATRKRSVVRRCLKMAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLD
WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVAR
SAMMQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELL
EHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLA
QQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSS
WLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAP

--------------------------------------------------------------
>61954_61954_13_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000543004_RPS6KA4_chr11_64132773_ENST00000294261_length(transcript)=1660nt_BP=257nt
GCTGTTTAAAGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGCCGCTGGGCAGCGACTCCGAAGGTGTTAACTGTCTGGCCTATG
ATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGGACATGACAGATCCCTGCCTCCTCCAGATTGCTGTGCAGAACCCTCTGG
TGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCAAGGGCCTCGATTGGG
TGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTC
GGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTC
TCTTTGACCACAACAACGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCG
AGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGC
AGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCA
CCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGC
TGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAG
CCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGG
AGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTT
ATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAG
GACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGA
GTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGAC
TGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTT
TATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCT
TTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCTGTGCCT

>61954_61954_13_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000543004_RPS6KA4_chr11_64132773_ENST00000294261_length(amino acids)=304AA_BP=0
MAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEDMTDPCLLQIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLDWVALA
ARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAAEIMCKIREGRFSLDGEAWQGVSEEAK
ELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSA

--------------------------------------------------------------
>61954_61954_14_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000543004_RPS6KA4_chr11_64132773_ENST00000334205_length(transcript)=2405nt_BP=257nt
GCTGTTTAAAGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGCCGCTGGGCAGCGACTCCGAAGGTGTTAACTGTCTGGCCTATG
ATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGGACATGACAGATCCCTGCCTCCTCCAGATTGCTGTGCAGAACCCTCTGG
TGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCAAGGGCCTCGATTGGG
TGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTC
GGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTC
TCTTTGACCACAACAACGCGGTGATGACCGATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGTGGCCAGGAGCG
CTATGATGCAGGACTCGCCCTTCTTCCAGCAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCC
GCTGCCGCCAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGGCTGCCC
TGCGCCTGTGCCAGTCACACCCCAACGTGGTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTGC
GGGGCGGGGAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCG
TGAGCTTCATGCACGAGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCGG
TGAAAATCATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCACGCTGCAGTACGCTG
CCCCCGAGCTGCTGGCGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAGG
TCCCCTTCCAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACG
GGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGG
GACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCG
CAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCC
TGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCG
CCTCCAAAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGA
CCTGGGAGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACT
CCCAGACAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGT
GGGGTTTGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCC
CCACTTCTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCA
CCCCTCAACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACC
CTCTGAAGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCC
ATCTTCTCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTG

>61954_61954_14_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000543004_RPS6KA4_chr11_64132773_ENST00000334205_length(amino acids)=552AA_BP=0
MAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEDMTDPCLLQIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLDWVALA
ARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQ
DSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGE
LLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPEL
LAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRG
SSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKG

--------------------------------------------------------------
>61954_61954_15_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000543004_RPS6KA4_chr11_64132773_ENST00000528057_length(transcript)=2384nt_BP=257nt
GCTGTTTAAAGATGGCGGCGGAGGAACCTCAGCAGCAGAAGCAGGAGCCGCTGGGCAGCGACTCCGAAGGTGTTAACTGTCTGGCCTATG
ATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGGACATGACAGATCCCTGCCTCCTCCAGATTGCTGTGCAGAACCCTCTGG
TGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCAAGGGCCTCGATTGGG
TGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTC
GGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTC
TCTTTGACCACAACAACGCGGTGATGACCGATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGTGGCCAGGAGCG
CTATGATGCAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCCGCTGCCGCCAGCGCCAGAGCG
GCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCCTGTGCCAGTCACACC
CCAACGTGGTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTGCGGGGCGGGGAGCTGCTGGAGC
ACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCTTCATGCACGAGGAGG
CGGGCGTGGTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCGGTGAAAATCATCGACTTCGGGT
TCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCGAGCTGCTGGCGCAGC
AGGGCTACGACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAGGTCCCCTTCCAGGGGGCCTCTG
GCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTAT
CCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGC
TGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACG
CCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGA
AGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCC
GAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCC
CGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGTATT
TTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCC
CAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTA
GGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATG
GACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCA
CTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCC
TCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCTGTG

>61954_61954_15_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000543004_RPS6KA4_chr11_64132773_ENST00000528057_length(amino acids)=545AA_BP=0
MAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEDMTDPCLLQIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLDWVALA
ARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQ
YELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRK
KRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYD
ESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDG
SARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANG

--------------------------------------------------------------
>61954_61954_16_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000543988_RPS6KA4_chr11_64132773_ENST00000294261_length(transcript)=1761nt_BP=358nt
CCTTGCAGTCAGGCAGAGAGGCCTACGCCAGGGCCGAGCCCCCCGGCCTGCTCCAGCGGCGGCCCGCGCCGTGAGGGCCTCGAGTTTCGC
TGGGCTACGGAGCACAAAGGTCCGGGCGGGCCATTCGGGATGTCGTAGGCGGCCCTGGGATGTGAGGGGCCTGCGGGATCTGTCCCTGAG
GCCTGCGACTTTTTCTGGTGTTAACTGTCTGGCCTATGATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTGTGCA
GAACCCTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCAAGGG
CCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGA
GGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGC
ACCCTCCATTCTCTTTGACCACAACAACGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCA
GGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAG
CTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGG
TCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCG
GAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGC
CCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGG
CTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCA
GAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGG
CCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCA
CTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTC
ACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTT
CTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCA
CCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCC

>61954_61954_16_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000543988_RPS6KA4_chr11_64132773_ENST00000294261_length(amino acids)=288AA_BP=5
MRDLSLRPATFSGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLDWVALAARKIPAPFRPQIRSEL
DVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLK
LEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRA

--------------------------------------------------------------
>61954_61954_17_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000543988_RPS6KA4_chr11_64132773_ENST00000334205_length(transcript)=2506nt_BP=358nt
CCTTGCAGTCAGGCAGAGAGGCCTACGCCAGGGCCGAGCCCCCCGGCCTGCTCCAGCGGCGGCCCGCGCCGTGAGGGCCTCGAGTTTCGC
TGGGCTACGGAGCACAAAGGTCCGGGCGGGCCATTCGGGATGTCGTAGGCGGCCCTGGGATGTGAGGGGCCTGCGGGATCTGTCCCTGAG
GCCTGCGACTTTTTCTGGTGTTAACTGTCTGGCCTATGATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTGTGCA
GAACCCTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCAAGGG
CCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGA
GGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGC
ACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACCGATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGT
GGCCAGGAGCGCTATGATGCAGGACTCGCCCTTCTTCCAGCAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTC
TGTGTGTCGCCGCTGCCGCCAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGCGCGA
AGTGGCTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTGGTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCT
GGAGCTGCTGCGGGGCGGGGAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCAGCCT
CGTGTCGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCC
CGGGGCCCCGGTGAAAATCATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCACGCT
GCAGTACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCT
GTCGGGGCAGGTCCCCTTCCAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTT
CTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCT
GAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTC
CTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGA
GAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCG
AGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCAT
AGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTAC
CCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCC
TGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAA
GAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCC
TGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGC
CCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAA
AAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATC

>61954_61954_17_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000543988_RPS6KA4_chr11_64132773_ENST00000334205_length(amino acids)=536AA_BP=5
MRDLSLRPATFSGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLDWVALAARKIPAPFRPQIRSEL
DVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPA
LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEA
SQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLG
VILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLR

--------------------------------------------------------------
>61954_61954_18_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000543988_RPS6KA4_chr11_64132773_ENST00000528057_length(transcript)=2485nt_BP=358nt
CCTTGCAGTCAGGCAGAGAGGCCTACGCCAGGGCCGAGCCCCCCGGCCTGCTCCAGCGGCGGCCCGCGCCGTGAGGGCCTCGAGTTTCGC
TGGGCTACGGAGCACAAAGGTCCGGGCGGGCCATTCGGGATGTCGTAGGCGGCCCTGGGATGTGAGGGGCCTGCGGGATCTGTCCCTGAG
GCCTGCGACTTTTTCTGGTGTTAACTGTCTGGCCTATGATGAAGCCATCATGGCTCAGCAGGACCGAATTCAGCAAGAGATTGCTGTGCA
GAACCCTCTGGTGTCAGAGCGGCTGGAGCTCTCGGTCCTATACAAGGAGTATGCTGAAGATGACAACATCTATCAACAGAAGATCAAGGG
CCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGA
GGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGC
ACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACCGATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGT
GGCCAGGAGCGCTATGATGCAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCCGCTGCCGCCA
GCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCCTGTG
CCAGTCACACCCCAACGTGGTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTGCGGGGCGGGGA
GCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCTTCAT
GCACGAGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCGGTGAAAATCAT
CGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCGAGCT
GCTGGCGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAGGTCCCCTTCCA
GGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTG
GCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGG
CAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTC
GGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCG
GCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGG
GGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCC
CGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGA
GCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGG
GGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAA
GCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACT
GTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCA
TTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCAC
CCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCA

>61954_61954_18_OTUB1-RPS6KA4_OTUB1_chr11_63756224_ENST00000543988_RPS6KA4_chr11_64132773_ENST00000528057_length(amino acids)=529AA_BP=5
MRDLSLRPATFSGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKGLDWVALAARKIPAPFRPQIRSEL
DVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQYELDLREPALGQGSFS
VCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSL
VSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMML
SGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLES

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Fusion Gene PPI Analysis for OTUB1-RPS6KA4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OTUB1-RPS6KA4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OTUB1-RPS6KA4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource