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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OXNAD1-LRRTM4 (FusionGDB2 ID:62023)

Fusion Gene Summary for OXNAD1-LRRTM4

check button Fusion gene summary
Fusion gene informationFusion gene name: OXNAD1-LRRTM4
Fusion gene ID: 62023
HgeneTgene
Gene symbol

OXNAD1

LRRTM4

Gene ID

92106

80059

Gene nameoxidoreductase NAD binding domain containing 1leucine rich repeat transmembrane neuronal 4
Synonyms--
Cytomap

3p25.1-p24.3

2p12

Type of geneprotein-codingprotein-coding
Descriptionoxidoreductase NAD-binding domain-containing protein 1leucine-rich repeat transmembrane neuronal protein 4
Modification date2020031320200313
UniProtAcc.

Q86VH4

Ensembl transtripts involved in fusion geneENST00000285083, ENST00000435829, 
ENST00000544043, ENST00000605932, 
ENST00000606098, ENST00000607329, 
ENST00000409088, ENST00000409282, 
ENST00000491242, ENST00000409884, 
ENST00000409911, ENST00000409093, 
Fusion gene scores* DoF score3 X 4 X 2=247 X 7 X 2=98
# samples 47
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OXNAD1 [Title/Abstract] AND LRRTM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOXNAD1(16327955)-LRRTM4(76976042), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across OXNAD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRRTM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TZ-01AOXNAD1chr3

16327955

-LRRTM4chr2

76976042

-
ChimerDB4BRCATCGA-AR-A0TZ-01AOXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
ChimerDB4BRCATCGA-AR-A0TZOXNAD1chr3

16327955

+LRRTM4chr2

76976042

-


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Fusion Gene ORF analysis for OXNAD1-LRRTM4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000285083ENST00000409088OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
5CDS-intronENST00000285083ENST00000409282OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
5CDS-intronENST00000285083ENST00000491242OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
5CDS-intronENST00000435829ENST00000409088OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
5CDS-intronENST00000435829ENST00000409282OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
5CDS-intronENST00000435829ENST00000491242OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
5CDS-intronENST00000544043ENST00000409088OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
5CDS-intronENST00000544043ENST00000409282OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
5CDS-intronENST00000544043ENST00000491242OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
5CDS-intronENST00000605932ENST00000409088OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
5CDS-intronENST00000605932ENST00000409282OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
5CDS-intronENST00000605932ENST00000491242OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
5CDS-intronENST00000606098ENST00000409088OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
5CDS-intronENST00000606098ENST00000409282OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
5CDS-intronENST00000606098ENST00000491242OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
Frame-shiftENST00000285083ENST00000409884OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
Frame-shiftENST00000285083ENST00000409911OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
Frame-shiftENST00000435829ENST00000409884OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
Frame-shiftENST00000435829ENST00000409911OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
Frame-shiftENST00000544043ENST00000409884OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
Frame-shiftENST00000544043ENST00000409911OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
Frame-shiftENST00000605932ENST00000409884OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
Frame-shiftENST00000605932ENST00000409911OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
Frame-shiftENST00000606098ENST00000409884OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
Frame-shiftENST00000606098ENST00000409911OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
In-frameENST00000285083ENST00000409093OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
In-frameENST00000435829ENST00000409093OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
In-frameENST00000544043ENST00000409093OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
In-frameENST00000605932ENST00000409093OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
In-frameENST00000606098ENST00000409093OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
intron-3CDSENST00000607329ENST00000409093OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
intron-3CDSENST00000607329ENST00000409884OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
intron-3CDSENST00000607329ENST00000409911OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
intron-intronENST00000607329ENST00000409088OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
intron-intronENST00000607329ENST00000409282OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-
intron-intronENST00000607329ENST00000491242OXNAD1chr3

16327955

+LRRTM4chr2

76976042

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000606098OXNAD1chr316327955+ENST00000409093LRRTM4chr276976042-84748819848896
ENST00000285083OXNAD1chr316327955+ENST00000409093LRRTM4chr276976042-111475546575596
ENST00000605932OXNAD1chr316327955+ENST00000409093LRRTM4chr276976042-111175246275296
ENST00000435829OXNAD1chr316327955+ENST00000409093LRRTM4chr276976042-1119760290760156
ENST00000544043OXNAD1chr316327955+ENST00000409093LRRTM4chr276976042-7083495349114

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000606098ENST00000409093OXNAD1chr316327955+LRRTM4chr276976042-0.207656620.79234344
ENST00000285083ENST00000409093OXNAD1chr316327955+LRRTM4chr276976042-0.128423410.87157655
ENST00000605932ENST00000409093OXNAD1chr316327955+LRRTM4chr276976042-0.165241610.8347584
ENST00000435829ENST00000409093OXNAD1chr316327955+LRRTM4chr276976042-0.180546340.81945366
ENST00000544043ENST00000409093OXNAD1chr316327955+LRRTM4chr276976042-0.165387690.8346123

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Fusion Genomic Features for OXNAD1-LRRTM4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for OXNAD1-LRRTM4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:16327955/chr2:76976042)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LRRTM4

Q86VH4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040908803311_3620519.0DomainNote=LRRCT
TgeneLRRTM4chr3:16327955chr2:76976042ENST000004090880331_610519.0DomainNote=LRRNT
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040908803110_1310519.0RepeatNote=LRR 3
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040908803134_1550519.0RepeatNote=LRR 4
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040908803158_1790519.0RepeatNote=LRR 5
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040908803182_2030519.0RepeatNote=LRR 6
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040908803206_2260519.0RepeatNote=LRR 7
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040908803230_2510519.0RepeatNote=LRR 8
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040908803254_2750519.0RepeatNote=LRR 9
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040908803278_2990519.0RepeatNote=LRR 10
TgeneLRRTM4chr3:16327955chr2:76976042ENST000004090880362_830519.0RepeatNote=LRR 1
TgeneLRRTM4chr3:16327955chr2:76976042ENST000004090880386_1070519.0RepeatNote=LRR 2
TgeneLRRTM4chr3:16327955chr2:76976042ENST000004090880331_4240519.0Topological domainExtracellular
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040908803446_5900519.0Topological domainCytoplasmic
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040908803425_4450519.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOXNAD1chr3:16327955chr2:76976042ENST00000285083+5950_18696313.0DomainFAD-binding FR-type
HgeneOXNAD1chr3:16327955chr2:76976042ENST00000605932+51050_18696295.0DomainFAD-binding FR-type
HgeneOXNAD1chr3:16327955chr2:76976042ENST00000285083+59178_18396313.0Nucleotide bindingNAD
HgeneOXNAD1chr3:16327955chr2:76976042ENST00000605932+510178_18396295.0Nucleotide bindingNAD
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040909324311_362517591.0DomainNote=LRRCT
TgeneLRRTM4chr3:16327955chr2:76976042ENST000004090932431_61517591.0DomainNote=LRRNT
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040988424311_362517591.0DomainNote=LRRCT
TgeneLRRTM4chr3:16327955chr2:76976042ENST000004098842431_61517591.0DomainNote=LRRNT
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040909324110_131517591.0RepeatNote=LRR 3
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040909324134_155517591.0RepeatNote=LRR 4
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040909324158_179517591.0RepeatNote=LRR 5
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040909324182_203517591.0RepeatNote=LRR 6
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040909324206_226517591.0RepeatNote=LRR 7
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040909324230_251517591.0RepeatNote=LRR 8
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040909324254_275517591.0RepeatNote=LRR 9
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040909324278_299517591.0RepeatNote=LRR 10
TgeneLRRTM4chr3:16327955chr2:76976042ENST000004090932462_83517591.0RepeatNote=LRR 1
TgeneLRRTM4chr3:16327955chr2:76976042ENST000004090932486_107517591.0RepeatNote=LRR 2
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040988424110_131517591.0RepeatNote=LRR 3
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040988424134_155517591.0RepeatNote=LRR 4
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040988424158_179517591.0RepeatNote=LRR 5
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040988424182_203517591.0RepeatNote=LRR 6
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040988424206_226517591.0RepeatNote=LRR 7
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040988424230_251517591.0RepeatNote=LRR 8
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040988424254_275517591.0RepeatNote=LRR 9
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040988424278_299517591.0RepeatNote=LRR 10
TgeneLRRTM4chr3:16327955chr2:76976042ENST000004098842462_83517591.0RepeatNote=LRR 1
TgeneLRRTM4chr3:16327955chr2:76976042ENST000004098842486_107517591.0RepeatNote=LRR 2
TgeneLRRTM4chr3:16327955chr2:76976042ENST000004090932431_424517591.0Topological domainExtracellular
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040909324446_590517591.0Topological domainCytoplasmic
TgeneLRRTM4chr3:16327955chr2:76976042ENST000004098842431_424517591.0Topological domainExtracellular
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040988424446_590517591.0Topological domainCytoplasmic
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040909324425_445517591.0TransmembraneHelical
TgeneLRRTM4chr3:16327955chr2:76976042ENST0000040988424425_445517591.0TransmembraneHelical


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Fusion Gene Sequence for OXNAD1-LRRTM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>62023_62023_1_OXNAD1-LRRTM4_OXNAD1_chr3_16327955_ENST00000285083_LRRTM4_chr2_76976042_ENST00000409093_length(transcript)=1114nt_BP=755nt
CTGGGACCGCGGAGTATTCCAGGCGCCTGCAACTAAACGTGGCCGGGTCTGCAAGCTAGGTGCCAGCGGGGAAAGTTTCCCTGCTTCTTA
TCGTCTGCTTTAACGCCTTAAATAGCCCGCTGAAGGCTGCAGCAGGTGCTAGGTAGCAGCCTCCCGGCCCTCGGGAAAGGCGGGGTGGGG
AGGCGAGAGCAGCTTAGCCTCCTCGACCTCCCTTCCTGGTGACGGACGAACAGTTCCCGTAGAATTTCGCTTCACCGAGTGACCTTGAGC
CCAGGGCGACGGTCAGCTTGTTAATTCCTGGCTGCAGGAACTTTGTGAGAATTTTAATGCATGGAAAAGCTGTCCATGTTCCAACTGCTG
TACATCCAAAAGTCTCAGTGTAATAGCAGGACCAAAATATTCTGTCAATCAGCTGACCATATACTTAATGACTCCTAAAATCTCGTGGAC
TTCTAAGAAAGCGCCATGGCCTGTGCTGCTGTTATGATTCCTGGGTTGTTGCGGTGCTCTGTTGGAGCCATCCGTATTGAGGCTGCGTCA
CTGAGATTGACACTCAGCACTTTGCGCCACCTTACTCTAACCAGCATAATGAAATCCAAAAGGAAAACTGATCACATGGAGAGAACTGCA
AGTGTCCTTCGACGGGAGATTGTGTCAGCAGCTAAGGTGTGTGGAGCTGCCAGTGAGTCACCGTCAGTGAAGAGCCTCCGCTTGCTTGTT
GCTGATCAAGACTTTTCCTTTAAAGCTGGCCAGTGATGCCACACCACATGAAGCCCTTGCCATATTACAGCTATGACCAGCCTGTGATCG
GGTACTGCCAGGCCCACCAGCCACTCCATGTCACCAAGGGCTATGAGACAGTGTCTCCAGAGCAGGACGAAAGCCCCGGCCTGGAGCTGG
GCCGAGACCACAGCTTCATCGCCACCATCGCCAGGTCGGCAGCACCGGCCATCTACCTAGAGAGAATTGCAAACTAACGCTGAAGCCAAC
TCCTCACTGGGGAGCTCCATGGGGGGGAGGGAGGGCCTTCATCTTAAAGGAGAATGGGTGTCCACAATCGCGCAATCGAGCAAGCTCATC

>62023_62023_1_OXNAD1-LRRTM4_OXNAD1_chr3_16327955_ENST00000285083_LRRTM4_chr2_76976042_ENST00000409093_length(amino acids)=96AA_BP=
MACAAVMIPGLLRCSVGAIRIEAASLRLTLSTLRHLTLTSIMKSKRKTDHMERTASVLRREIVSAAKVCGAASESPSVKSLRLLVADQDF

--------------------------------------------------------------
>62023_62023_2_OXNAD1-LRRTM4_OXNAD1_chr3_16327955_ENST00000435829_LRRTM4_chr2_76976042_ENST00000409093_length(transcript)=1119nt_BP=760nt
GAGTATTCCAGGCGCCTGCAACTAAACGTGGCCGGGTCTGCAAGCTAGGTGCCAGCGGGGAAAGTTTCCCTGCTTCTTATCGTCTGCTTT
AACGCCTTAAATAGCCCGCTGAAGGCTGCAGCAGGTGCTAGGTAGCAGCCTCCCGGCCCTCGGGAAAGGCGGGGTGGGGAGGCGAGAGCA
GCTTAGCCTCCTCGACCTCCCTTCCTGGTGACGGACGAACAGTTCCCGTAGAATTTCGCTTCACCGAGTGACCTTGAGCCCAGGGCGACG
GTCAGCTTGTTAATTCCTGGCTGCAGGAACTTTGTGAGAATTTTAATGCATGGAAAAGCTGTCCATGTTCCAACTGCTGTACATCCAAAA
GTCTCAGTGTAATAGCAGGACCAAAATATTCTGTCAATCAGCTGACCATATACTTAATGACTCCTAAAATCTCGTGGACTTCTAAGTTTT
CTGTTTGCCCAGAAAGCGCCATGGCCTGTGCTGCTGTTATGATTCCTGGGTTGTTGCGGTGCTCTGTTGGAGCCATCCGTATTGAGGCTG
CGTCACTGAGATTGACACTCAGCACTTTGCGCCACCTTACTCTAACCAGCATAATGAAATCCAAAAGGAAAACTGATCACATGGAGAGAA
CTGCAAGTGTCCTTCGACGGGAGATTGTGTCAGCAGCTAAGGTGTGTGGAGCTGCCAGTGAGTCACCGTCAGTGAAGAGCCTCCGCTTGC
TTGTTGCTGATCAAGACTTTTCCTTTAAAGCTGGCCAGTGATGCCACACCACATGAAGCCCTTGCCATATTACAGCTATGACCAGCCTGT
GATCGGGTACTGCCAGGCCCACCAGCCACTCCATGTCACCAAGGGCTATGAGACAGTGTCTCCAGAGCAGGACGAAAGCCCCGGCCTGGA
GCTGGGCCGAGACCACAGCTTCATCGCCACCATCGCCAGGTCGGCAGCACCGGCCATCTACCTAGAGAGAATTGCAAACTAACGCTGAAG
CCAACTCCTCACTGGGGAGCTCCATGGGGGGGAGGGAGGGCCTTCATCTTAAAGGAGAATGGGTGTCCACAATCGCGCAATCGAGCAAGC

>62023_62023_2_OXNAD1-LRRTM4_OXNAD1_chr3_16327955_ENST00000435829_LRRTM4_chr2_76976042_ENST00000409093_length(amino acids)=156AA_BP=
MQELCENFNAWKSCPCSNCCTSKSLSVIAGPKYSVNQLTIYLMTPKISWTSKFSVCPESAMACAAVMIPGLLRCSVGAIRIEAASLRLTL

--------------------------------------------------------------
>62023_62023_3_OXNAD1-LRRTM4_OXNAD1_chr3_16327955_ENST00000544043_LRRTM4_chr2_76976042_ENST00000409093_length(transcript)=708nt_BP=349nt
ACTTAATGACTCCTAAAATCTCGTGGACTTCTAAGTTTTCTGTTTGCCCAGAAAGCGCCATGGCCTGTGCTGCTGTTATGATTCCTGGGT
TGTTGCGGTGCTCTGTTGGAGCCATCCGTATTGAGGCTGCGTCACTGAGATTGACACTCAGCACTTTGCGCCACCTTACTCTAACCAGCA
TAATGAAATCCAAAAGGAAAACTGATCACATGGAGAGAACTGCAAGTGTCCTTCGACGGGAGATTGTGTCAGCAGCTAAGGTGTGTGGAG
CTGCCAGTGAGTCACCGTCAGTGAAGAGCCTCCGCTTGCTTGTTGCTGATCAAGACTTTTCCTTTAAAGCTGGCCAGTGATGCCACACCA
CATGAAGCCCTTGCCATATTACAGCTATGACCAGCCTGTGATCGGGTACTGCCAGGCCCACCAGCCACTCCATGTCACCAAGGGCTATGA
GACAGTGTCTCCAGAGCAGGACGAAAGCCCCGGCCTGGAGCTGGGCCGAGACCACAGCTTCATCGCCACCATCGCCAGGTCGGCAGCACC
GGCCATCTACCTAGAGAGAATTGCAAACTAACGCTGAAGCCAACTCCTCACTGGGGAGCTCCATGGGGGGGAGGGAGGGCCTTCATCTTA

>62023_62023_3_OXNAD1-LRRTM4_OXNAD1_chr3_16327955_ENST00000544043_LRRTM4_chr2_76976042_ENST00000409093_length(amino acids)=114AA_BP=
MTPKISWTSKFSVCPESAMACAAVMIPGLLRCSVGAIRIEAASLRLTLSTLRHLTLTSIMKSKRKTDHMERTASVLRREIVSAAKVCGAA

--------------------------------------------------------------
>62023_62023_4_OXNAD1-LRRTM4_OXNAD1_chr3_16327955_ENST00000605932_LRRTM4_chr2_76976042_ENST00000409093_length(transcript)=1111nt_BP=752nt
GGACCGCGGAGTATTCCAGGCGCCTGCAACTAAACGTGGCCGGGTCTGCAAGCTAGGTGCCAGCGGGGAAAGTTTCCCTGCTTCTTATCG
TCTGCTTTAACGCCTTAAATAGCCCGCTGAAGGCTGCAGCAGGTGCTAGGTAGCAGCCTCCCGGCCCTCGGGAAAGGCGGGGTGGGGAGG
CGAGAGCAGCTTAGCCTCCTCGACCTCCCTTCCTGGTGACGGACGAACAGTTCCCGTAGAATTTCGCTTCACCGAGTGACCTTGAGCCCA
GGGCGACGGTCAGCTTGTTAATTCCTGGCTGCAGGAACTTTGTGAGAATTTTAATGCATGGAAAAGCTGTCCATGTTCCAACTGCTGTAC
ATCCAAAAGTCTCAGTGTAATAGCAGGACCAAAATATTCTGTCAATCAGCTGACCATATACTTAATGACTCCTAAAATCTCGTGGACTTC
TAAGAAAGCGCCATGGCCTGTGCTGCTGTTATGATTCCTGGGTTGTTGCGGTGCTCTGTTGGAGCCATCCGTATTGAGGCTGCGTCACTG
AGATTGACACTCAGCACTTTGCGCCACCTTACTCTAACCAGCATAATGAAATCCAAAAGGAAAACTGATCACATGGAGAGAACTGCAAGT
GTCCTTCGACGGGAGATTGTGTCAGCAGCTAAGGTGTGTGGAGCTGCCAGTGAGTCACCGTCAGTGAAGAGCCTCCGCTTGCTTGTTGCT
GATCAAGACTTTTCCTTTAAAGCTGGCCAGTGATGCCACACCACATGAAGCCCTTGCCATATTACAGCTATGACCAGCCTGTGATCGGGT
ACTGCCAGGCCCACCAGCCACTCCATGTCACCAAGGGCTATGAGACAGTGTCTCCAGAGCAGGACGAAAGCCCCGGCCTGGAGCTGGGCC
GAGACCACAGCTTCATCGCCACCATCGCCAGGTCGGCAGCACCGGCCATCTACCTAGAGAGAATTGCAAACTAACGCTGAAGCCAACTCC
TCACTGGGGAGCTCCATGGGGGGGAGGGAGGGCCTTCATCTTAAAGGAGAATGGGTGTCCACAATCGCGCAATCGAGCAAGCTCATCGTT

>62023_62023_4_OXNAD1-LRRTM4_OXNAD1_chr3_16327955_ENST00000605932_LRRTM4_chr2_76976042_ENST00000409093_length(amino acids)=96AA_BP=
MACAAVMIPGLLRCSVGAIRIEAASLRLTLSTLRHLTLTSIMKSKRKTDHMERTASVLRREIVSAAKVCGAASESPSVKSLRLLVADQDF

--------------------------------------------------------------
>62023_62023_5_OXNAD1-LRRTM4_OXNAD1_chr3_16327955_ENST00000606098_LRRTM4_chr2_76976042_ENST00000409093_length(transcript)=847nt_BP=488nt
AGCCCAGGGCGACGGTCAGCTTGTTAATTCCTGGCTGCAGGAACTTTGTGAGAATTTTAATGCATGGAAAAGCTGTCCATGTTCCAACTG
CTGTACATCCAAAAGTCTCAGTGTAATAGCAGGACCAAAATATTCTGTCAATCAGCTGACCATATACTTAATGACTCCTAAAATCTCGTG
GACTTCTAAGAAAGCGCCATGGCCTGTGCTGCTGTTATGATTCCTGGGTTGTTGCGGTGCTCTGTTGGAGCCATCCGTATTGAGGCTGCG
TCACTGAGATTGACACTCAGCACTTTGCGCCACCTTACTCTAACCAGCATAATGAAATCCAAAAGGAAAACTGATCACATGGAGAGAACT
GCAAGTGTCCTTCGACGGGAGATTGTGTCAGCAGCTAAGGTGTGTGGAGCTGCCAGTGAGTCACCGTCAGTGAAGAGCCTCCGCTTGCTT
GTTGCTGATCAAGACTTTTCCTTTAAAGCTGGCCAGTGATGCCACACCACATGAAGCCCTTGCCATATTACAGCTATGACCAGCCTGTGA
TCGGGTACTGCCAGGCCCACCAGCCACTCCATGTCACCAAGGGCTATGAGACAGTGTCTCCAGAGCAGGACGAAAGCCCCGGCCTGGAGC
TGGGCCGAGACCACAGCTTCATCGCCACCATCGCCAGGTCGGCAGCACCGGCCATCTACCTAGAGAGAATTGCAAACTAACGCTGAAGCC
AACTCCTCACTGGGGAGCTCCATGGGGGGGAGGGAGGGCCTTCATCTTAAAGGAGAATGGGTGTCCACAATCGCGCAATCGAGCAAGCTC

>62023_62023_5_OXNAD1-LRRTM4_OXNAD1_chr3_16327955_ENST00000606098_LRRTM4_chr2_76976042_ENST00000409093_length(amino acids)=96AA_BP=
MACAAVMIPGLLRCSVGAIRIEAASLRLTLSTLRHLTLTSIMKSKRKTDHMERTASVLRREIVSAAKVCGAASESPSVKSLRLLVADQDF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for OXNAD1-LRRTM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OXNAD1-LRRTM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OXNAD1-LRRTM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource