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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ARHGEF12-KPNA1 (FusionGDB2 ID:6211) |
Fusion Gene Summary for ARHGEF12-KPNA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGEF12-KPNA1 | Fusion gene ID: 6211 | Hgene | Tgene | Gene symbol | ARHGEF12 | KPNA1 | Gene ID | 23365 | 3836 |
| Gene name | Rho guanine nucleotide exchange factor 12 | karyopherin subunit alpha 1 | |
| Synonyms | LARG|PRO2792 | IPOA5|NPI-1|RCH2|SRP1 | |
| Cytomap | 11q23.3 | 3q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho guanine nucleotide exchange factor 12Rho guanine nucleotide exchange factor (GEF) 12leukemia-associated RhoGEFleukemia-associated rho guanine nucleotide exchange factor | importin subunit alpha-5RAG cohort protein 2SRP1-betaimportin alpha 5importin subunit alpha-1importin-alpha-S1karyopherin alpha 1 (importin alpha 5)nucleoprotein interactor 1recombination activating gene cohort 2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9NZN5 | P52294 | |
| Ensembl transtripts involved in fusion gene | ENST00000356641, ENST00000397843, ENST00000532993, | ENST00000466923, ENST00000344337, | |
| Fusion gene scores | * DoF score | 16 X 13 X 9=1872 | 3 X 3 X 2=18 |
| # samples | 21 | 3 | |
| ** MAII score | log2(21/1872*10)=-3.15611920191728 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ARHGEF12 [Title/Abstract] AND KPNA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ARHGEF12(120308091)-KPNA1(122156142), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARHGEF12 | GO:0007186 | G protein-coupled receptor signaling pathway | 15755723 |
| Fusion gene breakpoints across ARHGEF12 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across KPNA1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-CD-8525-01A | ARHGEF12 | chr11 | 120308091 | + | KPNA1 | chr3 | 122156142 | - |
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Fusion Gene ORF analysis for ARHGEF12-KPNA1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000356641 | ENST00000466923 | ARHGEF12 | chr11 | 120308091 | + | KPNA1 | chr3 | 122156142 | - |
| 5CDS-5UTR | ENST00000397843 | ENST00000466923 | ARHGEF12 | chr11 | 120308091 | + | KPNA1 | chr3 | 122156142 | - |
| 5CDS-5UTR | ENST00000532993 | ENST00000466923 | ARHGEF12 | chr11 | 120308091 | + | KPNA1 | chr3 | 122156142 | - |
| In-frame | ENST00000356641 | ENST00000344337 | ARHGEF12 | chr11 | 120308091 | + | KPNA1 | chr3 | 122156142 | - |
| In-frame | ENST00000397843 | ENST00000344337 | ARHGEF12 | chr11 | 120308091 | + | KPNA1 | chr3 | 122156142 | - |
| In-frame | ENST00000532993 | ENST00000344337 | ARHGEF12 | chr11 | 120308091 | + | KPNA1 | chr3 | 122156142 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000397843 | ARHGEF12 | chr11 | 120308091 | + | ENST00000344337 | KPNA1 | chr3 | 122156142 | - | 6822 | 1165 | 166 | 1785 | 539 |
| ENST00000356641 | ARHGEF12 | chr11 | 120308091 | + | ENST00000344337 | KPNA1 | chr3 | 122156142 | - | 6606 | 949 | 7 | 1569 | 520 |
| ENST00000532993 | ARHGEF12 | chr11 | 120308091 | + | ENST00000344337 | KPNA1 | chr3 | 122156142 | - | 6817 | 1160 | 230 | 1780 | 516 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000397843 | ENST00000344337 | ARHGEF12 | chr11 | 120308091 | + | KPNA1 | chr3 | 122156142 | - | 0.000206906 | 0.9997931 |
| ENST00000356641 | ENST00000344337 | ARHGEF12 | chr11 | 120308091 | + | KPNA1 | chr3 | 122156142 | - | 0.000211704 | 0.99978834 |
| ENST00000532993 | ENST00000344337 | ARHGEF12 | chr11 | 120308091 | + | KPNA1 | chr3 | 122156142 | - | 0.000211599 | 0.99978846 |
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Fusion Genomic Features for ARHGEF12-KPNA1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ARHGEF12-KPNA1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:120308091/chr3:122156142) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGEF12 | KPNA1 |
| FUNCTION: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. | FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ARHGEF12 | chr11:120308091 | chr3:122156142 | ENST00000356641 | + | 11 | 40 | 194_262 | 314 | 1526.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ARHGEF12 | chr11:120308091 | chr3:122156142 | ENST00000397843 | + | 12 | 41 | 194_262 | 333 | 1545.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ARHGEF12 | chr11:120308091 | chr3:122156142 | ENST00000356641 | + | 11 | 40 | 72_151 | 314 | 1526.0 | Domain | PDZ |
| Hgene | ARHGEF12 | chr11:120308091 | chr3:122156142 | ENST00000397843 | + | 12 | 41 | 72_151 | 333 | 1545.0 | Domain | PDZ |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 331_372 | 332 | 539.0 | Repeat | Note=ARM 7 | |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 373_412 | 332 | 539.0 | Repeat | Note=ARM 8 | |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 413_457 | 332 | 539.0 | Repeat | Note=ARM 9 | |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 460_504 | 332 | 539.0 | Repeat | Note=ARM 10%3B atypical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ARHGEF12 | chr11:120308091 | chr3:122156142 | ENST00000356641 | + | 11 | 40 | 1019_1132 | 314 | 1526.0 | Domain | PH |
| Hgene | ARHGEF12 | chr11:120308091 | chr3:122156142 | ENST00000356641 | + | 11 | 40 | 367_558 | 314 | 1526.0 | Domain | Note=RGSL |
| Hgene | ARHGEF12 | chr11:120308091 | chr3:122156142 | ENST00000356641 | + | 11 | 40 | 787_977 | 314 | 1526.0 | Domain | DH |
| Hgene | ARHGEF12 | chr11:120308091 | chr3:122156142 | ENST00000397843 | + | 12 | 41 | 1019_1132 | 333 | 1545.0 | Domain | PH |
| Hgene | ARHGEF12 | chr11:120308091 | chr3:122156142 | ENST00000397843 | + | 12 | 41 | 367_558 | 333 | 1545.0 | Domain | Note=RGSL |
| Hgene | ARHGEF12 | chr11:120308091 | chr3:122156142 | ENST00000397843 | + | 12 | 41 | 787_977 | 333 | 1545.0 | Domain | DH |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 25_28 | 332 | 539.0 | Compositional bias | Note=Poly-Arg | |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 1_57 | 332 | 539.0 | Domain | IBB | |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 42_51 | 332 | 539.0 | Motif | Nuclear localization signal | |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 149_241 | 332 | 539.0 | Region | NLS binding site (major) | |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 245_437 | 332 | 539.0 | Region | Note=Binding to RAG1 | |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 318_406 | 332 | 539.0 | Region | NLS binding site (minor) | |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 118_161 | 332 | 539.0 | Repeat | Note=ARM 2 | |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 162_206 | 332 | 539.0 | Repeat | Note=ARM 3 | |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 207_245 | 332 | 539.0 | Repeat | Note=ARM 4 | |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 246_290 | 332 | 539.0 | Repeat | Note=ARM 5 | |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 291_330 | 332 | 539.0 | Repeat | Note=ARM 6 | |
| Tgene | KPNA1 | chr11:120308091 | chr3:122156142 | ENST00000344337 | 9 | 14 | 77_117 | 332 | 539.0 | Repeat | Note=ARM 1%3B truncated |
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Fusion Gene Sequence for ARHGEF12-KPNA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >6211_6211_1_ARHGEF12-KPNA1_ARHGEF12_chr11_120308091_ENST00000356641_KPNA1_chr3_122156142_ENST00000344337_length(transcript)=6606nt_BP=949nt GGCCCCAATGAGTGGCACACAGTCTACTATCACCGACAGGTTTCCCCTCAAAAAACCTATAAGGCATGGAAGTATTTTGAACCGAGAGTC ACCAACAGATAAGAAGCAGAAAGTTGAGCGCATTGCATCACATGATTTTGACCCCACAGGTCTTGTTCAGCGTTGCGTAATCATCCAGAA AGATGACAATGGATTTGGGCTGACGGTCAGTGGAGACAATCCAGTCTTCGTACAGTCTGTCAAAGAAGATGGAGCAGCCATGCGGGCTGG AGTACAGACAGGTGATCGAATCATCAAGGTGAATGGAACTCTGGTGACTCATTCAAATCATCTGGAGGTGGTGAAGCTAATCAAATCTGG TTCCTATGTAGCTCTCACTGTTCAGGGACGCCCACCTGGGTCGCCCCAGATTCCACTTGCCGACTCTGAAGTAGAGCCGTCAGTCATTGG ACATATGTCTCCCATCATGACATCTCCTCATTCACCTGGAGCATCTGGGAATATGGAGAGAATCACTAGTCCTGTGCTCATGGGGGAGGA AAACAATGTGGTTCATAACCAGAAAGTAGAAATTCTGAGAAAAATGTTACAGAAAGAACAGGAACGGCTACAGTTATTGCAGGAAGATTA CAACCGAACACCTGCCCAAAGATTGCTAAAAGAGATCCAAGAGGCCAAGAAACACATTCCTCAGCTGCAAGAGCAGTTATCCAAAGCCAC AGGCTCTGCTCAGGATGGAGCTGTAGTTACACCCTCCAGACCTTTAGGGGACACCCTAACAGTCAGTGAGGCAGAAACAGATCCTGGAGA TGTACTGGGCAGGACTGACTGTAGCAGTGGAGATGCTTCTCGGCCCAGTAGTGACAATGCAGATAGTCCCAAGAGTGGCCCAAAAGAGAG AATTTATCTAGAGGAAAACCCAGAGAAAAGTGAAACAATTCAGGACACTGTAATTCTGAATTGCTCAGCTCTGCAGAGTTTATTGCATTT GCTGAGTAGCCCAAAGGAATCTATCAAAAAGGAAGCATGTTGGACGATATCTAATATTACAGCTGGAAATAGGGCACAGATCCAGACTGT GATAGATGCCAACATTTTCCCAGCCCTCATTAGTATTTTACAAACTGCTGAATTTCGGACAAGAAAAGAAGCAGCTTGGGCCATCACAAA TGCAACTTCTGGAGGATCAGCTGAACAGATCAAGTACCTAGTAGAACTGGGTTGTATCAAGCCGCTCTGTGATCTCCTCACGGTCATGGA CTCTAAGATTGTACAGGTTGCCCTAAATGGCTTGGAAAATATCCTGAGGCTTGGAGAACAGGAAGCCAAAAGGAATGGCACTGGCATTAA CCCTTACTGTGCTTTGATTGAAGAAGCTTATGGTCTGGATAAAATTGAGTTCTTACAGAGTCATGAAAACCAGGAGATCTACCAAAAGGC CTTTGATCTTATTGAGCATTACTTCGGGACCGAAGATGAAGACAGCAGCATTGCACCCCAGGTTGACCTTAACCAGCAGCAGTACATCTT CCAACAGTGTGAGGCTCCTATGGAAGGTTTCCAGCTTTGAAGCAATACTCTGCTTTCACGTACCTGTGTCAGACCAGGCTACCCAGTCGA GTCCTCTTGTGGAGCCCACAGTCCTCATGGAGCTAACTTCTCAAATGTTTTCCATAATACTGTTTGCGCTCATTTGCTTGCCTTGCGCAC CTGCTCTCTTACACACATCTGGAAAACCTCCGGCTCTCTGTGGTGGAATACCCTTCTAATAAAAGGGTAACCAGAACGGCCCACTCTCTT TTACGGAAAAATCCCTAGGCTTTGGAGATCCGCACTTACATTAGAGTTATGGGAATATACACATATTAATGTGGCTCCCTTTTTCTTGTG GGGGAATAAAAGAGGACTCCTCCTCATTCCCTTTAACATGGGGGAAAAAACTGACATTAAAAGATGAGACTAAATCTTTATCTTGAATTT TACACAACTACTTACGACAAGGGAGATGTTTAGACCTGTTGTGTATACTTCAGAGTACTTTTCATGAGTTCTTCCACAGTGAACCCTTGG ATTACCTGGTGGCTTTTTCTAGCCAGATTTGCATTAATCCTTACTGAGATTGGATGGTTTTCTTTCCTCTATTGGCGCCATTCTTCAGAT ATTAAAGTTAAACCATCCACTCCCTCACCTTCAGCCTTCAGTGAATGTGCTTTCTAGTTGTCAGGAATGCTGAAGAATTAACACTTTGAC TCCTAAATGTGATACTGGTTTGTAGATTCCCTTAGAGCAGAAAGGAGAGGGGCACATATTAATTTGTATCGCTTTTGCTTCTCTTTGGTC TTTTGTGTCTTAGAATTTGGAAGTGGTTCATTTCTGTTGCTGGTATGAGGATTTCGAATACTTAGTAATCGAAAACCATATCCTGTAATT TAATAAAAAAAACTAAGGACGAAAAAACCCTCCAATTTTCCCAAATGCAATCAGTGTAACTAGGGGCTGTGTTTCTGCATTAAAATAAAT GTTTCAGGCTTTGTGGTCCTGATCAAGGTCCTCATTAAAAAATTGGAGTTCACCCTAGGTGCTTTTCCCCTCTGTGACTGGCAGATAACA CATACTTTTGAAAGTAACTTTGGGATTTTTTTCTTAGGTGCAGCTCGATTCTAATCTTTTCATGCTGCACACGATTCCTTTAATGTAGCA TCCTTATCTGAAAGAAATAACCATCTTCTCAACATGACCTGCTTAACCCAAATAAGAACAGTGATCTTATAACCTCATTGTTTCCTAATC ATTTTATTTCATCTCCTGCTAGTACTGTGCCGCTTCCCCCTCCCCCCACACAAAATAAAAACAGTATCTGCCTTCTGGCTCATTTAATGA TGACTGCAATCTGTACCTGCAAATGGCGCTTCCAGTACTGTGTTCAGTGATCCACATTTGTGCTTGGACTGGAATGAAAAAATACGCTTA ATTGCCAAGACAACTGCAAATGAGTTCAATACGACTTCTCGGTGCTAGTTGGCCATCTTGACTCAATGTTGGGATACACTACCAGAGAAG ATTTTTTTGTTGATGTGCTGTTCAAAGTGAATTCTGAAGGAAAAGGTTGCTCACCTCTGTTTCAGAGCATACCCTTTTAAACCTTTTTAG ACTTGTCCTCTTCTAGAATTCATTATAACCCCAAAGTGTAAAAACTATTTGGAAGTTGCCCCTGACAAGCTATTATACATCTCTGGTAAA TCCTGCTGAATGTAAGGGATATTCAGAGCTTTTCATACCTCATCATGATGTTATTTAAGCAGCCAACTTATGTGACCTGATTTAAACTTT TAAAAAATCCACTTCATTCAAACTAGAAAGAGTCAAAGACAAAGGACATTTATCAGCCAAGAGTGTGACGCATTCTTCGCATCTAGTCTG TAGTAGTGTCTGTGCTCTGGGATGGATACCGTCTGATGTCTGTTTGTTATTGATGGCGCAGCCACTGCAAAACTAGTCAACTCCCATCTA TAACTGTTACTTTTTCTAGTGCTGCTTTGTGCTGAGAGAACATTTTAGTTTACTGCACTTGACCTGTAAAAGACTGATTCTTTGTAATTT TAGGGATAAATTAGGTGGTTAATTTAAAGAAGAAATTTCAATGTTGCCTTTACATCACATTAAAATATAACTTCTTTCAGAAGGATAATA GAAGCACTGATTCATAGTAAAAATCTTGTTTTTAGCTTTGACTTTTTTGTGGCTGTTTTTTAAAATTGTAAATTACTAGTAACATGTCAT TTCTATAGGATGTTTTAAATTATGTACCTTCCATTGGATAGTTAAAATAATTTCATTTTATAAGCCAATTTGAGTGGGAAAGATACAAAG CACACAGTTGTCTCCCCACATTAGGAAGAGTAGTGTGCATTCAGACATTCGGAATTTTTGCTAGTAGTTGGAGATGTTTCAGTGAGTGAA TTAAAACAAAGTCTATTTAACTGACGTGATCTATTTTGTGTCTAAAACAGAGGAATTTATCTTGTCCTAGAAGTTCATGAACTATAAGAT CTAAGTTTTTTTTTCTTTTTTAACAATAAAATGATTTTTTCTTAAAGTATCAAAGTTGGAATTGGCTAAAAGTGAAGTAGCATAACTCAG ATATGTTGGAACTTGGTACTGAAGCAGGCTTTTTGGTAACAGAAATGACATTTTAAGGGGTAACTGTATATCCTGTTTTTAGTTCTTTGC CTCTCAGATTCTGTTAACTTAGTTTAAATTCACTGAATACCCTACCACTAAGGCGTTGCTCATTACAAAAGCATGTTAATTTCAATACAG GAAAACTCTTTTGTAGTTTTATATATGGATTGGGGAAAGTGACTTTGTTTTACTTTTCCTTTTTATTCCCCTCCATCCTCCAAACTTCCA ATCTATATTATTTGTAATGAGAACTTTGGTGGGGGAAAAAAAGCATTAAGAGAATTTTGGATGTAAAGGCATCTGGTATCTGATGGACCA GCAGGTAGATGTGGTTGGATTGAGAAATTTTGGGTAAGGTAGATGATAGAAGAAAGAGATTTTAGGAGACACAGTTCTCTGTGGAACACT TTCTTTCATGTTCCTGTAACTAATTGATCAAGACCCTTTTAAACGCTTATCTTTGTCAGTTCCGCTTTTGAAAAAACTATTGCCCTAGGA TTGTTTCTTCCATATGACAGATGAAGGTTATTGGCTCTGAGTCATTTTTGGCATTATCGTCACAGATAAAAAGATTGGCAATTAATCTCA TAAAAAATCTGAATTATTCCAGATTGCTGCCGATTTTTGCCTAAGAAACAATATGTAAGTATATTTTATAAACCAAACTTTGTCAACCAA TTCTATTGTACGTCTACCCACAGGCAACTTTGAATTTACTTCTCTAGTGCTAAATAAACATTTCAGCGATTTAATCCCCCAACTTGGGGG ATGCATTATGAAAAGGTTTTCCTGGAGTCAAGGGGTTTTTCTTTCTCGCTAGTTTTGTGAAAATTTTTATATCAATAGGCAAATCATTAT AACTTTTTAGGGGTTGATGGTTTTTAAGTATATTGGAAATTGTGGTGTCTAAGGATGATGTTCAGTGAAGAAAAGGGATCCACTTTTAGA AACCAGCATTGTTTGCTTTCAACTTTCATACTGTATGCTAACTCCTACGTTCCAAAATGTGCTCATTTGCAGACACAGGTATGCCTATAT ACATGGAAGTCTCAAATCTGAATTTTTATCCATCTCAATATGACCATTTCTCTCTGTTGTGAGCTGAACAGATTAAGTATATATCTGCCA GGTTGGGAAATATTTTGGTCTATCTTTTCCTGTCATCAGAACTTAATTTAAAAAAATTATCAAAGGTCAGATGTGACTACTACAGTAAGT TGGCTATCATAAAGAATATTCCATAAAATGTTTTATCTGCCATACAAAATTACTGGGTTTATGGCCGGATGTGGTGGCTCATGCCTGTAA TCCCAGCAGTTCAGGATTACAGGTTATATACAGGTTATAACAATGGATACCAGGACATCAGAATATCTGATAAAGCAAATATTTATATGC TAATTTAAAATATCAAATTGCTACTGGACATAAAATACATCTGGAAGCTTGGGGTAAGAAGAAAGAAAAGAAGTGTTCCGTTCTGTTTTC AACTAAGGGTAAACGAAGTCCCAGAGTGTTTTCCCTGTAGGTCAAATTAAGGTAACATGTCTTTATTTGATCATCTATTGTACACCAGAT ACCTGGCTAAGGGCTTTCCTTTTTTCTCATGTAGTCTTCCAAATGTTCTTTGATAATTGTCACTATATTATAGATGACAAAGTGAAGACT TACGAGAAATTACTTTGCCCCAAGGTTACAACACTTAGATGGCTGTCCAAGGGCGGGGAAGAGCCCTGCAAATTCTGTGTCTTGAAGAAA GCAGTGGCCACGCAGTAGTTCCGTGCCCAGGATCTCCCAGAACTAGACTTGGCAACCACAGCTGGGCCAGCCTTTTTTGTTAGACCATTC TTCCTGACTCCTGCTTACCATCAGCACCCTTAAAATGACGAAATCAGGCTTAAGTTGCTTTTAGGTTACACAGACTGGAGTGTAGGCCCT CTCAGGCCAAACATCTTTCCTCTTCTGTGGTGCTAAAATTCTGTATGACCAGACAAGTATGGTAATAGGTTTTTTTTTTTTTTTTTTTTG TGCAAATGATTTTGTGTTTAGTAAAATAATGGCTAAACACATGGATCCATTCAAACGCACAAATGTGGAAAGTATTGACACGGAAGGAAA GGCTTTGAAGAATTACTGCCTCAGGAAGCAGTGCCATGGATGCGAATTTAACACAGTCTACTTCTTCCTAAAGGAATATCATCCCAAGGA ATGTCAAAAATTAAAATCACCTTTTAATGTACTGGTTGTTGAGTGTTTCTGCTTTACCTCAAGTCATTCTGACCACTCTACATCCTGCTT CAAAGTGTTCTGACACTTAGATTTGGAATGGCTCTAATGATTCTTTGTACTTGAATGTGGTCTGTCAGGCCATGGGTGAGTGCCTTGCAC >6211_6211_1_ARHGEF12-KPNA1_ARHGEF12_chr11_120308091_ENST00000356641_KPNA1_chr3_122156142_ENST00000344337_length(amino acids)=520AA_BP=314 MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQ TGDRIIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPGASGNMERITSPVLMGEENN VVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVL GRTDCSSGDASRPSSDNADSPKSGPKERIYLEENPEKSETIQDTVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVID ANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPY -------------------------------------------------------------- >6211_6211_2_ARHGEF12-KPNA1_ARHGEF12_chr11_120308091_ENST00000397843_KPNA1_chr3_122156142_ENST00000344337_length(transcript)=6822nt_BP=1165nt GTTGACCCCTTACAGTCGGATGGTCTAGATGACTGAATGGAGTTTTGAGTTGGACTTTTGTGTCCCTGACGGAGTTGGGCCTGATCCCAG AGCACTGGGGGTGGGGAGGAGGTGTTACTGTAAAATGCAAGTTGGATAAAAGGAGGACCTCTCGCCAAGGGCCCCAATGAGTGGCACACA GTCTACTATCACCGACAGGTTTCCCCTCAAAAAACCTATAAGGCATGGAAGTATTTTGAACCGAGAGTCACCAACAGATAAGAAGCAGAA AGTTGAGCGCATTGCATCACATGATTTTGACCCCACAGATAGCTCCTCCAAGAAGACAAAGTCTAGTTCAGAGGAGAGTAGATCCGAGAT ATATGGTCTTGTTCAGCGTTGCGTAATCATCCAGAAAGATGACAATGGATTTGGGCTGACGGTCAGTGGAGACAATCCAGTCTTCGTACA GTCTGTCAAAGAAGATGGAGCAGCCATGCGGGCTGGAGTACAGACAGGTGATCGAATCATCAAGGTGAATGGAACTCTGGTGACTCATTC AAATCATCTGGAGGTGGTGAAGCTAATCAAATCTGGTTCCTATGTAGCTCTCACTGTTCAGGGACGCCCACCTGGGTCGCCCCAGATTCC ACTTGCCGACTCTGAAGTAGAGCCGTCAGTCATTGGACATATGTCTCCCATCATGACATCTCCTCATTCACCTGGAGCATCTGGGAATAT GGAGAGAATCACTAGTCCTGTGCTCATGGGGGAGGAAAACAATGTGGTTCATAACCAGAAAGTAGAAATTCTGAGAAAAATGTTACAGAA AGAACAGGAACGGCTACAGTTATTGCAGGAAGATTACAACCGAACACCTGCCCAAAGATTGCTAAAAGAGATCCAAGAGGCCAAGAAACA CATTCCTCAGCTGCAAGAGCAGTTATCCAAAGCCACAGGCTCTGCTCAGGATGGAGCTGTAGTTACACCCTCCAGACCTTTAGGGGACAC CCTAACAGTCAGTGAGGCAGAAACAGATCCTGGAGATGTACTGGGCAGGACTGACTGTAGCAGTGGAGATGCTTCTCGGCCCAGTAGTGA CAATGCAGATAGTCCCAAGAGTGGCCCAAAAGAGAGAATTTATCTAGAGGAAAACCCAGAGAAAAGTGAAACAATTCAGGACACTGTAAT TCTGAATTGCTCAGCTCTGCAGAGTTTATTGCATTTGCTGAGTAGCCCAAAGGAATCTATCAAAAAGGAAGCATGTTGGACGATATCTAA TATTACAGCTGGAAATAGGGCACAGATCCAGACTGTGATAGATGCCAACATTTTCCCAGCCCTCATTAGTATTTTACAAACTGCTGAATT TCGGACAAGAAAAGAAGCAGCTTGGGCCATCACAAATGCAACTTCTGGAGGATCAGCTGAACAGATCAAGTACCTAGTAGAACTGGGTTG TATCAAGCCGCTCTGTGATCTCCTCACGGTCATGGACTCTAAGATTGTACAGGTTGCCCTAAATGGCTTGGAAAATATCCTGAGGCTTGG AGAACAGGAAGCCAAAAGGAATGGCACTGGCATTAACCCTTACTGTGCTTTGATTGAAGAAGCTTATGGTCTGGATAAAATTGAGTTCTT ACAGAGTCATGAAAACCAGGAGATCTACCAAAAGGCCTTTGATCTTATTGAGCATTACTTCGGGACCGAAGATGAAGACAGCAGCATTGC ACCCCAGGTTGACCTTAACCAGCAGCAGTACATCTTCCAACAGTGTGAGGCTCCTATGGAAGGTTTCCAGCTTTGAAGCAATACTCTGCT TTCACGTACCTGTGTCAGACCAGGCTACCCAGTCGAGTCCTCTTGTGGAGCCCACAGTCCTCATGGAGCTAACTTCTCAAATGTTTTCCA TAATACTGTTTGCGCTCATTTGCTTGCCTTGCGCACCTGCTCTCTTACACACATCTGGAAAACCTCCGGCTCTCTGTGGTGGAATACCCT TCTAATAAAAGGGTAACCAGAACGGCCCACTCTCTTTTACGGAAAAATCCCTAGGCTTTGGAGATCCGCACTTACATTAGAGTTATGGGA ATATACACATATTAATGTGGCTCCCTTTTTCTTGTGGGGGAATAAAAGAGGACTCCTCCTCATTCCCTTTAACATGGGGGAAAAAACTGA CATTAAAAGATGAGACTAAATCTTTATCTTGAATTTTACACAACTACTTACGACAAGGGAGATGTTTAGACCTGTTGTGTATACTTCAGA GTACTTTTCATGAGTTCTTCCACAGTGAACCCTTGGATTACCTGGTGGCTTTTTCTAGCCAGATTTGCATTAATCCTTACTGAGATTGGA TGGTTTTCTTTCCTCTATTGGCGCCATTCTTCAGATATTAAAGTTAAACCATCCACTCCCTCACCTTCAGCCTTCAGTGAATGTGCTTTC TAGTTGTCAGGAATGCTGAAGAATTAACACTTTGACTCCTAAATGTGATACTGGTTTGTAGATTCCCTTAGAGCAGAAAGGAGAGGGGCA CATATTAATTTGTATCGCTTTTGCTTCTCTTTGGTCTTTTGTGTCTTAGAATTTGGAAGTGGTTCATTTCTGTTGCTGGTATGAGGATTT CGAATACTTAGTAATCGAAAACCATATCCTGTAATTTAATAAAAAAAACTAAGGACGAAAAAACCCTCCAATTTTCCCAAATGCAATCAG TGTAACTAGGGGCTGTGTTTCTGCATTAAAATAAATGTTTCAGGCTTTGTGGTCCTGATCAAGGTCCTCATTAAAAAATTGGAGTTCACC CTAGGTGCTTTTCCCCTCTGTGACTGGCAGATAACACATACTTTTGAAAGTAACTTTGGGATTTTTTTCTTAGGTGCAGCTCGATTCTAA TCTTTTCATGCTGCACACGATTCCTTTAATGTAGCATCCTTATCTGAAAGAAATAACCATCTTCTCAACATGACCTGCTTAACCCAAATA AGAACAGTGATCTTATAACCTCATTGTTTCCTAATCATTTTATTTCATCTCCTGCTAGTACTGTGCCGCTTCCCCCTCCCCCCACACAAA ATAAAAACAGTATCTGCCTTCTGGCTCATTTAATGATGACTGCAATCTGTACCTGCAAATGGCGCTTCCAGTACTGTGTTCAGTGATCCA CATTTGTGCTTGGACTGGAATGAAAAAATACGCTTAATTGCCAAGACAACTGCAAATGAGTTCAATACGACTTCTCGGTGCTAGTTGGCC ATCTTGACTCAATGTTGGGATACACTACCAGAGAAGATTTTTTTGTTGATGTGCTGTTCAAAGTGAATTCTGAAGGAAAAGGTTGCTCAC CTCTGTTTCAGAGCATACCCTTTTAAACCTTTTTAGACTTGTCCTCTTCTAGAATTCATTATAACCCCAAAGTGTAAAAACTATTTGGAA GTTGCCCCTGACAAGCTATTATACATCTCTGGTAAATCCTGCTGAATGTAAGGGATATTCAGAGCTTTTCATACCTCATCATGATGTTAT TTAAGCAGCCAACTTATGTGACCTGATTTAAACTTTTAAAAAATCCACTTCATTCAAACTAGAAAGAGTCAAAGACAAAGGACATTTATC AGCCAAGAGTGTGACGCATTCTTCGCATCTAGTCTGTAGTAGTGTCTGTGCTCTGGGATGGATACCGTCTGATGTCTGTTTGTTATTGAT GGCGCAGCCACTGCAAAACTAGTCAACTCCCATCTATAACTGTTACTTTTTCTAGTGCTGCTTTGTGCTGAGAGAACATTTTAGTTTACT GCACTTGACCTGTAAAAGACTGATTCTTTGTAATTTTAGGGATAAATTAGGTGGTTAATTTAAAGAAGAAATTTCAATGTTGCCTTTACA TCACATTAAAATATAACTTCTTTCAGAAGGATAATAGAAGCACTGATTCATAGTAAAAATCTTGTTTTTAGCTTTGACTTTTTTGTGGCT GTTTTTTAAAATTGTAAATTACTAGTAACATGTCATTTCTATAGGATGTTTTAAATTATGTACCTTCCATTGGATAGTTAAAATAATTTC ATTTTATAAGCCAATTTGAGTGGGAAAGATACAAAGCACACAGTTGTCTCCCCACATTAGGAAGAGTAGTGTGCATTCAGACATTCGGAA TTTTTGCTAGTAGTTGGAGATGTTTCAGTGAGTGAATTAAAACAAAGTCTATTTAACTGACGTGATCTATTTTGTGTCTAAAACAGAGGA ATTTATCTTGTCCTAGAAGTTCATGAACTATAAGATCTAAGTTTTTTTTTCTTTTTTAACAATAAAATGATTTTTTCTTAAAGTATCAAA GTTGGAATTGGCTAAAAGTGAAGTAGCATAACTCAGATATGTTGGAACTTGGTACTGAAGCAGGCTTTTTGGTAACAGAAATGACATTTT AAGGGGTAACTGTATATCCTGTTTTTAGTTCTTTGCCTCTCAGATTCTGTTAACTTAGTTTAAATTCACTGAATACCCTACCACTAAGGC GTTGCTCATTACAAAAGCATGTTAATTTCAATACAGGAAAACTCTTTTGTAGTTTTATATATGGATTGGGGAAAGTGACTTTGTTTTACT TTTCCTTTTTATTCCCCTCCATCCTCCAAACTTCCAATCTATATTATTTGTAATGAGAACTTTGGTGGGGGAAAAAAAGCATTAAGAGAA TTTTGGATGTAAAGGCATCTGGTATCTGATGGACCAGCAGGTAGATGTGGTTGGATTGAGAAATTTTGGGTAAGGTAGATGATAGAAGAA AGAGATTTTAGGAGACACAGTTCTCTGTGGAACACTTTCTTTCATGTTCCTGTAACTAATTGATCAAGACCCTTTTAAACGCTTATCTTT GTCAGTTCCGCTTTTGAAAAAACTATTGCCCTAGGATTGTTTCTTCCATATGACAGATGAAGGTTATTGGCTCTGAGTCATTTTTGGCAT TATCGTCACAGATAAAAAGATTGGCAATTAATCTCATAAAAAATCTGAATTATTCCAGATTGCTGCCGATTTTTGCCTAAGAAACAATAT GTAAGTATATTTTATAAACCAAACTTTGTCAACCAATTCTATTGTACGTCTACCCACAGGCAACTTTGAATTTACTTCTCTAGTGCTAAA TAAACATTTCAGCGATTTAATCCCCCAACTTGGGGGATGCATTATGAAAAGGTTTTCCTGGAGTCAAGGGGTTTTTCTTTCTCGCTAGTT TTGTGAAAATTTTTATATCAATAGGCAAATCATTATAACTTTTTAGGGGTTGATGGTTTTTAAGTATATTGGAAATTGTGGTGTCTAAGG ATGATGTTCAGTGAAGAAAAGGGATCCACTTTTAGAAACCAGCATTGTTTGCTTTCAACTTTCATACTGTATGCTAACTCCTACGTTCCA AAATGTGCTCATTTGCAGACACAGGTATGCCTATATACATGGAAGTCTCAAATCTGAATTTTTATCCATCTCAATATGACCATTTCTCTC TGTTGTGAGCTGAACAGATTAAGTATATATCTGCCAGGTTGGGAAATATTTTGGTCTATCTTTTCCTGTCATCAGAACTTAATTTAAAAA AATTATCAAAGGTCAGATGTGACTACTACAGTAAGTTGGCTATCATAAAGAATATTCCATAAAATGTTTTATCTGCCATACAAAATTACT GGGTTTATGGCCGGATGTGGTGGCTCATGCCTGTAATCCCAGCAGTTCAGGATTACAGGTTATATACAGGTTATAACAATGGATACCAGG ACATCAGAATATCTGATAAAGCAAATATTTATATGCTAATTTAAAATATCAAATTGCTACTGGACATAAAATACATCTGGAAGCTTGGGG TAAGAAGAAAGAAAAGAAGTGTTCCGTTCTGTTTTCAACTAAGGGTAAACGAAGTCCCAGAGTGTTTTCCCTGTAGGTCAAATTAAGGTA ACATGTCTTTATTTGATCATCTATTGTACACCAGATACCTGGCTAAGGGCTTTCCTTTTTTCTCATGTAGTCTTCCAAATGTTCTTTGAT AATTGTCACTATATTATAGATGACAAAGTGAAGACTTACGAGAAATTACTTTGCCCCAAGGTTACAACACTTAGATGGCTGTCCAAGGGC GGGGAAGAGCCCTGCAAATTCTGTGTCTTGAAGAAAGCAGTGGCCACGCAGTAGTTCCGTGCCCAGGATCTCCCAGAACTAGACTTGGCA ACCACAGCTGGGCCAGCCTTTTTTGTTAGACCATTCTTCCTGACTCCTGCTTACCATCAGCACCCTTAAAATGACGAAATCAGGCTTAAG TTGCTTTTAGGTTACACAGACTGGAGTGTAGGCCCTCTCAGGCCAAACATCTTTCCTCTTCTGTGGTGCTAAAATTCTGTATGACCAGAC AAGTATGGTAATAGGTTTTTTTTTTTTTTTTTTTTGTGCAAATGATTTTGTGTTTAGTAAAATAATGGCTAAACACATGGATCCATTCAA ACGCACAAATGTGGAAAGTATTGACACGGAAGGAAAGGCTTTGAAGAATTACTGCCTCAGGAAGCAGTGCCATGGATGCGAATTTAACAC AGTCTACTTCTTCCTAAAGGAATATCATCCCAAGGAATGTCAAAAATTAAAATCACCTTTTAATGTACTGGTTGTTGAGTGTTTCTGCTT TACCTCAAGTCATTCTGACCACTCTACATCCTGCTTCAAAGTGTTCTGACACTTAGATTTGGAATGGCTCTAATGATTCTTTGTACTTGA >6211_6211_2_ARHGEF12-KPNA1_ARHGEF12_chr11_120308091_ENST00000397843_KPNA1_chr3_122156142_ENST00000344337_length(amino acids)=539AA_BP=333 MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEESRSEIYGLVQRCVIIQKDDNGFGLTVSGDN PVFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPG ASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVVTPSR PLGDTLTVSEAETDPGDVLGRTDCSSGDASRPSSDNADSPKSGPKERIYLEENPEKSETIQDTVILNCSALQSLLHLLSSPKESIKKEAC WTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLEN -------------------------------------------------------------- >6211_6211_3_ARHGEF12-KPNA1_ARHGEF12_chr11_120308091_ENST00000532993_KPNA1_chr3_122156142_ENST00000344337_length(transcript)=6817nt_BP=1160nt CTTCTTATCATCCCTCTTGTGGTCAGTAAAATCATCTGACAAATGCCTTTCCAAGGATGTCGAATGTATATATAAAGAAAAAGCTTAGGA TTGCTAAGGGAGTGGTATTTTGGTGAGGATTTCATTTTCTTCTACTCCATGGAAACGAGCCTTTTGAGCTTTTGCTTGTCTGCTGATTTG TCCGGTGATCCAGGTTTCCCCTCAAAAAACCTATAAGGCATGGAAGTATTTTGAACCGAGAGTCACCAACAGATAAGAAGCAGAAAGTTG AGCGCATTGCATCACATGATTTTGACCCCACAGATAGCTCCTCCAAGAAGACAAAGTCTAGTTCAGAGGAGAGTAGATCCGAGATATATG GTCTTGTTCAGCGTTGCGTAATCATCCAGAAAGATGACAATGGATTTGGGCTGACGGTCAGTGGAGACAATCCAGTCTTCGTACAGTCTG TCAAAGAAGATGGAGCAGCCATGCGGGCTGGAGTACAGACAGGTGATCGAATCATCAAGGTGAATGGAACTCTGGTGACTCATTCAAATC ATCTGGAGGTGGTGAAGCTAATCAAATCTGGTTCCTATGTAGCTCTCACTGTTCAGGGACGCCCACCTGGGTCGCCCCAGATTCCACTTG CCGACTCTGAAGTAGAGCCGTCAGTCATTGGACATATGTCTCCCATCATGACATCTCCTCATTCACCTGGAGCATCTGGGAATATGGAGA GAATCACTAGTCCTGTGCTCATGGGGGAGGAAAACAATGTGGTTCATAACCAGAAAGTAGAAATTCTGAGAAAAATGTTACAGAAAGAAC AGGAACGGCTACAGTTATTGCAGGAAGATTACAACCGAACACCTGCCCAAAGATTGCTAAAAGAGATCCAAGAGGCCAAGAAACACATTC CTCAGCTGCAAGAGCAGTTATCCAAAGCCACAGGCTCTGCTCAGGATGGAGCTGTAGTTACACCCTCCAGACCTTTAGGGGACACCCTAA CAGTCAGTGAGGCAGAAACAGATCCTGGAGATGTACTGGGCAGGACTGACTGTAGCAGTGGAGATGCTTCTCGGCCCAGTAGTGACAATG CAGATAGTCCCAAGAGTGGCCCAAAAGAGAGAATTTATCTAGAGGAAAACCCAGAGAAAAGTGAAACAATTCAGGACACTGTAATTCTGA ATTGCTCAGCTCTGCAGAGTTTATTGCATTTGCTGAGTAGCCCAAAGGAATCTATCAAAAAGGAAGCATGTTGGACGATATCTAATATTA CAGCTGGAAATAGGGCACAGATCCAGACTGTGATAGATGCCAACATTTTCCCAGCCCTCATTAGTATTTTACAAACTGCTGAATTTCGGA CAAGAAAAGAAGCAGCTTGGGCCATCACAAATGCAACTTCTGGAGGATCAGCTGAACAGATCAAGTACCTAGTAGAACTGGGTTGTATCA AGCCGCTCTGTGATCTCCTCACGGTCATGGACTCTAAGATTGTACAGGTTGCCCTAAATGGCTTGGAAAATATCCTGAGGCTTGGAGAAC AGGAAGCCAAAAGGAATGGCACTGGCATTAACCCTTACTGTGCTTTGATTGAAGAAGCTTATGGTCTGGATAAAATTGAGTTCTTACAGA GTCATGAAAACCAGGAGATCTACCAAAAGGCCTTTGATCTTATTGAGCATTACTTCGGGACCGAAGATGAAGACAGCAGCATTGCACCCC AGGTTGACCTTAACCAGCAGCAGTACATCTTCCAACAGTGTGAGGCTCCTATGGAAGGTTTCCAGCTTTGAAGCAATACTCTGCTTTCAC GTACCTGTGTCAGACCAGGCTACCCAGTCGAGTCCTCTTGTGGAGCCCACAGTCCTCATGGAGCTAACTTCTCAAATGTTTTCCATAATA CTGTTTGCGCTCATTTGCTTGCCTTGCGCACCTGCTCTCTTACACACATCTGGAAAACCTCCGGCTCTCTGTGGTGGAATACCCTTCTAA TAAAAGGGTAACCAGAACGGCCCACTCTCTTTTACGGAAAAATCCCTAGGCTTTGGAGATCCGCACTTACATTAGAGTTATGGGAATATA CACATATTAATGTGGCTCCCTTTTTCTTGTGGGGGAATAAAAGAGGACTCCTCCTCATTCCCTTTAACATGGGGGAAAAAACTGACATTA AAAGATGAGACTAAATCTTTATCTTGAATTTTACACAACTACTTACGACAAGGGAGATGTTTAGACCTGTTGTGTATACTTCAGAGTACT TTTCATGAGTTCTTCCACAGTGAACCCTTGGATTACCTGGTGGCTTTTTCTAGCCAGATTTGCATTAATCCTTACTGAGATTGGATGGTT TTCTTTCCTCTATTGGCGCCATTCTTCAGATATTAAAGTTAAACCATCCACTCCCTCACCTTCAGCCTTCAGTGAATGTGCTTTCTAGTT GTCAGGAATGCTGAAGAATTAACACTTTGACTCCTAAATGTGATACTGGTTTGTAGATTCCCTTAGAGCAGAAAGGAGAGGGGCACATAT TAATTTGTATCGCTTTTGCTTCTCTTTGGTCTTTTGTGTCTTAGAATTTGGAAGTGGTTCATTTCTGTTGCTGGTATGAGGATTTCGAAT ACTTAGTAATCGAAAACCATATCCTGTAATTTAATAAAAAAAACTAAGGACGAAAAAACCCTCCAATTTTCCCAAATGCAATCAGTGTAA CTAGGGGCTGTGTTTCTGCATTAAAATAAATGTTTCAGGCTTTGTGGTCCTGATCAAGGTCCTCATTAAAAAATTGGAGTTCACCCTAGG TGCTTTTCCCCTCTGTGACTGGCAGATAACACATACTTTTGAAAGTAACTTTGGGATTTTTTTCTTAGGTGCAGCTCGATTCTAATCTTT TCATGCTGCACACGATTCCTTTAATGTAGCATCCTTATCTGAAAGAAATAACCATCTTCTCAACATGACCTGCTTAACCCAAATAAGAAC AGTGATCTTATAACCTCATTGTTTCCTAATCATTTTATTTCATCTCCTGCTAGTACTGTGCCGCTTCCCCCTCCCCCCACACAAAATAAA AACAGTATCTGCCTTCTGGCTCATTTAATGATGACTGCAATCTGTACCTGCAAATGGCGCTTCCAGTACTGTGTTCAGTGATCCACATTT GTGCTTGGACTGGAATGAAAAAATACGCTTAATTGCCAAGACAACTGCAAATGAGTTCAATACGACTTCTCGGTGCTAGTTGGCCATCTT GACTCAATGTTGGGATACACTACCAGAGAAGATTTTTTTGTTGATGTGCTGTTCAAAGTGAATTCTGAAGGAAAAGGTTGCTCACCTCTG TTTCAGAGCATACCCTTTTAAACCTTTTTAGACTTGTCCTCTTCTAGAATTCATTATAACCCCAAAGTGTAAAAACTATTTGGAAGTTGC CCCTGACAAGCTATTATACATCTCTGGTAAATCCTGCTGAATGTAAGGGATATTCAGAGCTTTTCATACCTCATCATGATGTTATTTAAG CAGCCAACTTATGTGACCTGATTTAAACTTTTAAAAAATCCACTTCATTCAAACTAGAAAGAGTCAAAGACAAAGGACATTTATCAGCCA AGAGTGTGACGCATTCTTCGCATCTAGTCTGTAGTAGTGTCTGTGCTCTGGGATGGATACCGTCTGATGTCTGTTTGTTATTGATGGCGC AGCCACTGCAAAACTAGTCAACTCCCATCTATAACTGTTACTTTTTCTAGTGCTGCTTTGTGCTGAGAGAACATTTTAGTTTACTGCACT TGACCTGTAAAAGACTGATTCTTTGTAATTTTAGGGATAAATTAGGTGGTTAATTTAAAGAAGAAATTTCAATGTTGCCTTTACATCACA TTAAAATATAACTTCTTTCAGAAGGATAATAGAAGCACTGATTCATAGTAAAAATCTTGTTTTTAGCTTTGACTTTTTTGTGGCTGTTTT TTAAAATTGTAAATTACTAGTAACATGTCATTTCTATAGGATGTTTTAAATTATGTACCTTCCATTGGATAGTTAAAATAATTTCATTTT ATAAGCCAATTTGAGTGGGAAAGATACAAAGCACACAGTTGTCTCCCCACATTAGGAAGAGTAGTGTGCATTCAGACATTCGGAATTTTT GCTAGTAGTTGGAGATGTTTCAGTGAGTGAATTAAAACAAAGTCTATTTAACTGACGTGATCTATTTTGTGTCTAAAACAGAGGAATTTA TCTTGTCCTAGAAGTTCATGAACTATAAGATCTAAGTTTTTTTTTCTTTTTTAACAATAAAATGATTTTTTCTTAAAGTATCAAAGTTGG AATTGGCTAAAAGTGAAGTAGCATAACTCAGATATGTTGGAACTTGGTACTGAAGCAGGCTTTTTGGTAACAGAAATGACATTTTAAGGG GTAACTGTATATCCTGTTTTTAGTTCTTTGCCTCTCAGATTCTGTTAACTTAGTTTAAATTCACTGAATACCCTACCACTAAGGCGTTGC TCATTACAAAAGCATGTTAATTTCAATACAGGAAAACTCTTTTGTAGTTTTATATATGGATTGGGGAAAGTGACTTTGTTTTACTTTTCC TTTTTATTCCCCTCCATCCTCCAAACTTCCAATCTATATTATTTGTAATGAGAACTTTGGTGGGGGAAAAAAAGCATTAAGAGAATTTTG GATGTAAAGGCATCTGGTATCTGATGGACCAGCAGGTAGATGTGGTTGGATTGAGAAATTTTGGGTAAGGTAGATGATAGAAGAAAGAGA TTTTAGGAGACACAGTTCTCTGTGGAACACTTTCTTTCATGTTCCTGTAACTAATTGATCAAGACCCTTTTAAACGCTTATCTTTGTCAG TTCCGCTTTTGAAAAAACTATTGCCCTAGGATTGTTTCTTCCATATGACAGATGAAGGTTATTGGCTCTGAGTCATTTTTGGCATTATCG TCACAGATAAAAAGATTGGCAATTAATCTCATAAAAAATCTGAATTATTCCAGATTGCTGCCGATTTTTGCCTAAGAAACAATATGTAAG TATATTTTATAAACCAAACTTTGTCAACCAATTCTATTGTACGTCTACCCACAGGCAACTTTGAATTTACTTCTCTAGTGCTAAATAAAC ATTTCAGCGATTTAATCCCCCAACTTGGGGGATGCATTATGAAAAGGTTTTCCTGGAGTCAAGGGGTTTTTCTTTCTCGCTAGTTTTGTG AAAATTTTTATATCAATAGGCAAATCATTATAACTTTTTAGGGGTTGATGGTTTTTAAGTATATTGGAAATTGTGGTGTCTAAGGATGAT GTTCAGTGAAGAAAAGGGATCCACTTTTAGAAACCAGCATTGTTTGCTTTCAACTTTCATACTGTATGCTAACTCCTACGTTCCAAAATG TGCTCATTTGCAGACACAGGTATGCCTATATACATGGAAGTCTCAAATCTGAATTTTTATCCATCTCAATATGACCATTTCTCTCTGTTG TGAGCTGAACAGATTAAGTATATATCTGCCAGGTTGGGAAATATTTTGGTCTATCTTTTCCTGTCATCAGAACTTAATTTAAAAAAATTA TCAAAGGTCAGATGTGACTACTACAGTAAGTTGGCTATCATAAAGAATATTCCATAAAATGTTTTATCTGCCATACAAAATTACTGGGTT TATGGCCGGATGTGGTGGCTCATGCCTGTAATCCCAGCAGTTCAGGATTACAGGTTATATACAGGTTATAACAATGGATACCAGGACATC AGAATATCTGATAAAGCAAATATTTATATGCTAATTTAAAATATCAAATTGCTACTGGACATAAAATACATCTGGAAGCTTGGGGTAAGA AGAAAGAAAAGAAGTGTTCCGTTCTGTTTTCAACTAAGGGTAAACGAAGTCCCAGAGTGTTTTCCCTGTAGGTCAAATTAAGGTAACATG TCTTTATTTGATCATCTATTGTACACCAGATACCTGGCTAAGGGCTTTCCTTTTTTCTCATGTAGTCTTCCAAATGTTCTTTGATAATTG TCACTATATTATAGATGACAAAGTGAAGACTTACGAGAAATTACTTTGCCCCAAGGTTACAACACTTAGATGGCTGTCCAAGGGCGGGGA AGAGCCCTGCAAATTCTGTGTCTTGAAGAAAGCAGTGGCCACGCAGTAGTTCCGTGCCCAGGATCTCCCAGAACTAGACTTGGCAACCAC AGCTGGGCCAGCCTTTTTTGTTAGACCATTCTTCCTGACTCCTGCTTACCATCAGCACCCTTAAAATGACGAAATCAGGCTTAAGTTGCT TTTAGGTTACACAGACTGGAGTGTAGGCCCTCTCAGGCCAAACATCTTTCCTCTTCTGTGGTGCTAAAATTCTGTATGACCAGACAAGTA TGGTAATAGGTTTTTTTTTTTTTTTTTTTTGTGCAAATGATTTTGTGTTTAGTAAAATAATGGCTAAACACATGGATCCATTCAAACGCA CAAATGTGGAAAGTATTGACACGGAAGGAAAGGCTTTGAAGAATTACTGCCTCAGGAAGCAGTGCCATGGATGCGAATTTAACACAGTCT ACTTCTTCCTAAAGGAATATCATCCCAAGGAATGTCAAAAATTAAAATCACCTTTTAATGTACTGGTTGTTGAGTGTTTCTGCTTTACCT CAAGTCATTCTGACCACTCTACATCCTGCTTCAAAGTGTTCTGACACTTAGATTTGGAATGGCTCTAATGATTCTTTGTACTTGAATGTG >6211_6211_3_ARHGEF12-KPNA1_ARHGEF12_chr11_120308091_ENST00000532993_KPNA1_chr3_122156142_ENST00000344337_length(amino acids)=516AA_BP=310 MNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEESRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDR IIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPGASGNMERITSPVLMGEENNVVHN QKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTD CSSGDASRPSSDNADSPKSGPKERIYLEENPEKSETIQDTVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIF PALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ARHGEF12-KPNA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARHGEF12-KPNA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARHGEF12-KPNA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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