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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:P4HB-MYO6 (FusionGDB2 ID:62142) |
Fusion Gene Summary for P4HB-MYO6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: P4HB-MYO6 | Fusion gene ID: 62142 | Hgene | Tgene | Gene symbol | P4HB | MYO6 | Gene ID | 5034 | 4646 |
| Gene name | prolyl 4-hydroxylase subunit beta | myosin VI | |
| Synonyms | CLCRP1|DSI|ERBA2L|GIT|P4Hbeta|PDI|PDIA1|PHDB|PO4DB|PO4HB|PROHB | DFNA22|DFNB37 | |
| Cytomap | 17q25.3 | 6q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein disulfide-isomerasecellular thyroid hormone-binding proteincollagen prolyl 4-hydroxylase betaglutathione-insulin transhydrogenasep55procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptideprolyl 4-hydroxyla | unconventional myosin-VIunconventional myosin-6 | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | . | Q9UM54 | |
| Ensembl transtripts involved in fusion gene | ENST00000331483, ENST00000439918, ENST00000472244, ENST00000576390, | ENST00000462633, ENST00000369975, ENST00000369977, ENST00000369981, ENST00000369985, | |
| Fusion gene scores | * DoF score | 34 X 19 X 17=10982 | 10 X 12 X 9=1080 |
| # samples | 37 | 13 | |
| ** MAII score | log2(37/10982*10)=-4.89147173542795 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/1080*10)=-3.05444778402238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: P4HB [Title/Abstract] AND MYO6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | P4HB(79801037)-MYO6(76595721), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | P4HB | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 7753822 |
| Tgene | MYO6 | GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 16507995 |
| Fusion gene breakpoints across P4HB (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MYO6 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-EJ-7784-01A | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
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Fusion Gene ORF analysis for P4HB-MYO6 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000331483 | ENST00000462633 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| In-frame | ENST00000331483 | ENST00000369975 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| In-frame | ENST00000331483 | ENST00000369977 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| In-frame | ENST00000331483 | ENST00000369981 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| In-frame | ENST00000331483 | ENST00000369985 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-3CDS | ENST00000439918 | ENST00000369975 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-3CDS | ENST00000439918 | ENST00000369977 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-3CDS | ENST00000439918 | ENST00000369981 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-3CDS | ENST00000439918 | ENST00000369985 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-3CDS | ENST00000472244 | ENST00000369975 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-3CDS | ENST00000472244 | ENST00000369977 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-3CDS | ENST00000472244 | ENST00000369981 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-3CDS | ENST00000472244 | ENST00000369985 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-3CDS | ENST00000576390 | ENST00000369975 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-3CDS | ENST00000576390 | ENST00000369977 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-3CDS | ENST00000576390 | ENST00000369981 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-3CDS | ENST00000576390 | ENST00000369985 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-intron | ENST00000439918 | ENST00000462633 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-intron | ENST00000472244 | ENST00000462633 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| intron-intron | ENST00000576390 | ENST00000462633 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000331483 | P4HB | chr17 | 79801037 | - | ENST00000369981 | MYO6 | chr6 | 76595721 | + | 8573 | 2603 | 1809 | 130 | 559 |
| ENST00000331483 | P4HB | chr17 | 79801037 | - | ENST00000369985 | MYO6 | chr6 | 76595721 | + | 8500 | 2603 | 1809 | 130 | 559 |
| ENST00000331483 | P4HB | chr17 | 79801037 | - | ENST00000369977 | MYO6 | chr6 | 76595721 | + | 5645 | 2603 | 1809 | 130 | 559 |
| ENST00000331483 | P4HB | chr17 | 79801037 | - | ENST00000369975 | MYO6 | chr6 | 76595721 | + | 5549 | 2603 | 1809 | 130 | 559 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000331483 | ENST00000369981 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + | 0.000198906 | 0.9998011 |
| ENST00000331483 | ENST00000369985 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + | 0.000200412 | 0.99979955 |
| ENST00000331483 | ENST00000369977 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + | 0.000525412 | 0.9994746 |
| ENST00000331483 | ENST00000369975 | P4HB | chr17 | 79801037 | - | MYO6 | chr6 | 76595721 | + | 0.00051909 | 0.9994809 |
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Fusion Genomic Features for P4HB-MYO6 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| P4HB | chr17 | 79801034 | - | MYO6 | chr6 | 76595720 | + | 2.70E-05 | 0.99997294 |
| P4HB | chr17 | 79801034 | - | MYO6 | chr6 | 76595720 | + | 2.70E-05 | 0.99997294 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for P4HB-MYO6 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:79801037/chr6:76595721) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | MYO6 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370). {ECO:0000250|UniProtKB:Q29122, ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370, ECO:0000269|PubMed:29467281}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | P4HB | chr17:79801037 | chr6:76595721 | ENST00000331483 | - | 11 | 11 | 18_134 | 793 | 509.0 | Domain | Thioredoxin 1 |
| Hgene | P4HB | chr17:79801037 | chr6:76595721 | ENST00000331483 | - | 11 | 11 | 349_475 | 793 | 509.0 | Domain | Thioredoxin 2 |
| Hgene | P4HB | chr17:79801037 | chr6:76595721 | ENST00000331483 | - | 11 | 11 | 505_508 | 793 | 509.0 | Motif | Note=Prevents secretion from ER |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369977 | 22 | 35 | 920_1027 | 805 | 1286.0 | Compositional bias | Note=Glu-rich | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369985 | 22 | 33 | 920_1027 | 805 | 1263.0 | Compositional bias | Note=Glu-rich | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369977 | 22 | 35 | 814_834 | 805 | 1286.0 | Domain | IQ | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369985 | 22 | 33 | 814_834 | 805 | 1263.0 | Domain | IQ | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369977 | 22 | 35 | 835_916 | 805 | 1286.0 | Region | Three-helix bundle | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369977 | 22 | 35 | 917_984 | 805 | 1286.0 | Region | SAH | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369985 | 22 | 33 | 835_916 | 805 | 1263.0 | Region | Three-helix bundle | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369985 | 22 | 33 | 917_984 | 805 | 1263.0 | Region | SAH |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369977 | 22 | 35 | 2_53 | 805 | 1286.0 | Domain | Myosin N-terminal SH3-like | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369977 | 22 | 35 | 57_771 | 805 | 1286.0 | Domain | Myosin motor | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369985 | 22 | 33 | 2_53 | 805 | 1263.0 | Domain | Myosin N-terminal SH3-like | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369985 | 22 | 33 | 57_771 | 805 | 1263.0 | Domain | Myosin motor | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369977 | 22 | 35 | 151_158 | 805 | 1286.0 | Nucleotide binding | ATP | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369985 | 22 | 33 | 151_158 | 805 | 1263.0 | Nucleotide binding | ATP | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369977 | 22 | 35 | 273_317 | 805 | 1286.0 | Region | Responsible for slow ATPase activity | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369977 | 22 | 35 | 665_672 | 805 | 1286.0 | Region | Actin-binding | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369977 | 22 | 35 | 782_810 | 805 | 1286.0 | Region | Required for binding calmodulin | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369985 | 22 | 33 | 273_317 | 805 | 1263.0 | Region | Responsible for slow ATPase activity | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369985 | 22 | 33 | 665_672 | 805 | 1263.0 | Region | Actin-binding | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369985 | 22 | 33 | 782_810 | 805 | 1263.0 | Region | Required for binding calmodulin |
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Fusion Gene Sequence for P4HB-MYO6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >62142_62142_1_P4HB-MYO6_P4HB_chr17_79801037_ENST00000331483_MYO6_chr6_76595721_ENST00000369975_length(transcript)=5549nt_BP=2603nt GTGTCCAATCCGAGAGCGGCAAAGACGAGCCTCGAAGTCCGCCGGCCAATCGAAGGCGGGCCCCAGCGGCGCGTGCGCGCCGCGGCCAGC GCGCGCGGGCGGGGGGGCAGGCGCGCCCCGGACCCAGGATTTATAAAGGCGAGGCCGGGACCGGCGCGCGCTCTCGTCGCCCCCGCTGTC CCGGCGGCGCCAACCGAAGCGCCCCGCCTGATCCGTGTCCGACATGCTGCGCCGCGCTCTGCTGTGCCTGGCCGTGGCCGCCCTGGTGCG CGCCGACGCCCCCGAGGAGGAGGACCACGTCCTGGTGCTGCGGAAAAGCAACTTCGCGGAGGCGCTGGCGGCCCACAAGTACCTGCTGGT GGAGTTCTATGCCCCTTGGTGTGGCCACTGCAAGGCTCTGGCCCCTGAGTATGCCAAAGCCGCTGGGAAGCTGAAGGCAGAAGGTTCCGA GATCAGGTTGGCCAAGGTGGACGCCACGGAGGAGTCTGACCTGGCCCAGCAGTACGGCGTGCGCGGCTATCCCACCATCAAGTTCTTCAG GAATGGAGACACGGCTTCCCCCAAGGAATATACAGCTGGCAGAGAGGCTGATGACATCGTGAACTGGCTGAAGAAGCGCACGGGCCCGGC TGCCACCACCCTGCCTGACGGCGCAGCTGCAGAGTCCTTGGTGGAGTCCAGCGAGGTGGCTGTCATCGGCTTCTTCAAGGACGTGGAGTC GGACTCTGCCAAGCAGTTTTTGCAGGCAGCAGAGGCCATCGATGACATACCATTTGGGATCACTTCCAACAGTGACGTGTTCTCCAAATA CCAGCTCGACAAAGATGGGGTTGTCCTCTTTAAGAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGAGAACCTGCT GGACTTTATCAAACACAACCAGCTGCCCCTTGTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAATCAAGACTCA CATCCTGCTGTTCTTGCCCAAGAGTGTGTCTGACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAAGGGCAAGAT CCTGTTCATCTTCATCGACAGCGACCACACCGACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCCGGCCGTGCG CCTCATCACCCTGGAGGAGGAGATGACCAAGTACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTGCCACCGCTT CCTGGAGGGCAAAATCAAGCCCCACCTGATGAGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGTTGGGAAGAA CTTTGAAGACGTGGCTTTTGATGAGAAAAAAAACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAGTTGGCTCCCAT TTGGGATAAACTGGGAGAGACGTACAAGGACCATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGAGGCCGTCAA AGTGCACAGCTTCCCCACACTCAAGTTCTTTCCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACGCTGGATGGTTT TAAGAAATTCCTGGAGAGCGGTGGCCAGGATGGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAGCCAGACATGGA GGAAGACGATGATCAGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGCTGCCGAGACCCCTCGGGGGCTGCACAC CCAGCAGCAGCGCACGCCTCCGAAGCCTGCGGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTCTCTGAAGTGACACCTC ACCCCTACACACCGTCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAGGCAGCCCACCCTGGTG GGGCTTGTTTCCTGAAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGAGTCTCGCTGCCTCCCT CCCGCGGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATTTGTTCCACCTTGGCCA GGCCTCCTCGGAGAAGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCTGCAGTGTCGCCATGAC TGATCATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCATGCCTGGAAGAGGAGCTGGTGGCTGCC AGCCCTGGGGCCCGGCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCATTGTGACCACTGGCCT CTCTACAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGGATGCTGGAGCTGAATC AGACGCTGACAGTTCTTCAGGCATTTCTATTTCACAATCGAATTGAACACATTGGCCAAATAAAGTTGAAATTTTACCACCTGTGAAAAA CAAAATAAAATATCGAGCTGAAGCCTGCATTAAAATGCAAAAAACTATTCGAATGTGGCTTTGCAAGAGGAGACACAAACCTCGCATTGA TGGTCTGGTTAAGGTGGGCACACTGAAAAAACGACTTGATAAATTTAATGAGGTAGTCAGTGTGTTGAAAGATGGAAAACCCGAGATGAA TAAACAGATCAAGAATCTGGAAATTTCTATTGATACTTTGATGGCCAAAATTAAGTCCACTATGATGACGCAGGAACAAATCCAGAAAGA ATATGATGCACTGGTTAAAAGCTCAGAGGAACTCCTCAGTGCATTACAGAAAAAAAAACAGCAGGAAGAGGAAGCAGAAAGGCTGAGGCG TATTCAAGAAGAAATGGAAAAGGAAAGAAAAAGACGTGAAGAAGACGAAAAACGTCGAAGAAAGGAAGAGGAGGAAAGGCGGATGAAACT TGAGATGGAAGCAAAGAGAAAACAAGAAGAAGAAGAGAGAAAGAAAAGGGAAGATGATGAAAAACGCATTCAAGCTGAAGTGGAGGCACA GCTGGCCCGACAGAAGGAGGAGGAATCCCAACAGCAAGCAGTTCTGGAGCAGGAGCGCAGGGACCGGGAGCTGGCCCTGAGGATTGCCCA GAGTGAAGCCGAGCTCATCAGTGATGAGGCCCAGGCCGACCTGGCGCTGCGGAGAGGTCCTGCTGTACTAGCCACCAAAGCAGCTGCTGG TACTAAGAAATATGATCTTAGTAAATGGAAATATGCAGAACTACGTGATACCATCAATACTTCTTGTGATATTGAGCTCCTGGCAGCTTG CAGAGAAGAATTTCATAGGAGACTAAAAGTGTATCATGCTTGGAAATCTAAGAACAAGAAGAGAAATACTGAAACAGAGCAACGTGCTCC AAAGTCTGTTACTGATTATGCTCAGCAAAACCCAGCAGCTCAGATTCCTGCCAGGCAGCGGGAGATTGAAATGAACCGACAGCAACGCTT CTTCCGCATCCCATTCATCCGCCCTGCCGACCAGTACAAAGACCCTCAGAGTAAGAAAAAAGGCTGGTGGTATGCCCATTTTGATGGACC ATGGATTGCCCGGCAAATGGAACTCCATCCTGACAAGCCACCCATCCTACTTGTGGCTGGTAAGGACGACATGGAGATGTGTGAGCTGAA TCTTGAGGAGACTGGCCTGACTCGGAAGCGTGGTGCTGAGATCTTGCCAAGACAGTTTGAAGAAATCTGGGAACGCTGTGGAGGCATCCA GTACCTTCAGAATGCGATTGAGAGCAGACAGGCTCGGCCCACCTATGCAACAGCCATGCTGCAGAGTCTGTTAAAGTAGATGTTGCACAC CAGCCTTACAGCTGGGAGCCTTTGCCATGGTACTTAGGTAGGGTGTGTGCCCCCAGATTTAACCATTCCATAATCATGTTAGAGTTACTT CTATAAAGTGAACAGATTTTATTAATCACGGCTTTTGGTGAATTTGTTTAAGGTTAATTATGGTAGCAAATTTTGGACCTAAACATTATT TTTCTGTATCCCGCTGTAATTCCCAAAACTCTCATTATTCTCTAACTATTACACATGGGCATATTCTGATGTTTCTCATCCTTTGCCAGA AGACTACCTTACATCCATCGTAATTGTTCTCTAGGAAAAGAGAACTTTTTTCAAAATTCAAAATACTTTTTAAGGATGGCACAGTACCAT ATAACTGGAGTAATAAAACATGAGCTTACATTCTTACAATAACTAAACCACTTAAAATGATCAAGGCACTAATGTTTTGGTCTGAAAAGC TGTGTACTTTATAGACATTTTCAGACATTTTTGGAAATTTCCATTAAAGGTGGAAAATCTATTTTTTTCCTCCTTTGCAGTGTCTTAGTT TGAATGAAACACTTCGAAGTTCTAGAATTCTAGAAAGAGCCTTAATGTATTTGATGTATTCTGTGATAAGAGGTACTAATAGTATCCAGC ACAGATTTGCTTTTCTTTGCTAGCACAATGTGTGTTGCTGTCAGAATATTCTTTTTATATTCTGTGGAAAAATAAAGGAAATTCAGATTG TTTAAATGCCTAAAAGTTTTGAGATAAGTTTTGTTTCAATTAGAAAAGGAAATAGGTTTTAGGTGGCATAGTGGCTTAACTGGACTGAAT TCAAATATTCTTTCAACTTCATCTCAATAGTGATTTTTGTATCAGAATCTTGTCCAAGTTGTTTCATTGATTTAGTAAGTGTTCTGCTTC CAACATCTTTCTTTTTAAGAAATTCCTAGTGTCTTTTTTGGCCTTTGAGGTTTTGGTAATTGTAGACCTGTTTCATAAGCTTTGTAATTC AGAAATCCTTGTATTTAGTAAGTGCTTGTTTTACATAACTGATAATTTTAAAATGTTTTCTTTGTGTGCTGTTAGTATTGATTCAAATGT CAGCAGCTTTAAGCCTAATATTTATGACTTTCACATTTGGAATTTAAAGACAAAAATACATCAAGGAGTTATGCTGACATAATTCTAAGG AGTTTTGTTGTATTTTAGAATAAAATTATAAAGTAAAATGATTCTCTGTACTGCTTTTTCCCCCAGTTTTTAGAGACCCTAACCTTTGAA ATGAAATTCCAGTGATTTCTTTTTTCCCTAGAAAGATTACCTCAGTTAGGGAAGTATTTCCCAGCTGACTAGTGTTTGTGAGCCACAGAC ACTGTCTTCAGAATTGCTTCTCTCATGTCTTAGTAGAGAAATATTTATTTATTATGATACATTCAAATGATTGTCAAGTTAAATTAAATG GTTGTGTCTGTGCTATTGAGAATGCAAATGTGATTATCTTTTGAAGGCTGTATTACTGCATAGCTTCACCCACCCTCGGGTCATTTCGTC >62142_62142_1_P4HB-MYO6_P4HB_chr17_79801037_ENST00000331483_MYO6_chr6_76595721_ENST00000369975_length(amino acids)=559AA_BP= MLLGVQPPRGLGSARVWLCVLQFIFHSFLIIVFLHVWLLCFFQVLEIVIIPCPILATALQEFLKTIQRAFPVVINDRPVGTGRKELECGE AVHFDGLHLVGSRVHLGDDDVLMVLVRLSQFIPNGSQLFAVTTPWGIELHKDVFFLIKSHVFKVLPNKHLDRLLVPVLRQLLAHQVGLDF ALQEAVAELCDPLCRQLLRFGLVLGHLLLQGDEAHGRALFLLQAKELEDALVVGVVAVDEDEQDLALEALGCCFEVAQFAVIVRHTLGQE QQDVSLDFTSKNLRGCLLGELDDKGQLVVFDKVQQVLLGDLPFKVVPAFIKLLKEDNPIFVELVFGEHVTVGSDPKWYVIDGLCCLQKLL GRVRLHVLEEADDSHLAGLHQGLCSCAVRQGGGSRARALLQPVHDVISLSASCIFLGGSRVSIPEELDGGIAAHAVLLGQVRLLRGVHLG QPDLGTFCLQLPSGFGILRGQSLAVATPRGIELHQQVLVGRQRLREVAFPQHQDVVLLLGGVGAHQGGHGQAQQSAAQHVGHGSGGALRL -------------------------------------------------------------- >62142_62142_2_P4HB-MYO6_P4HB_chr17_79801037_ENST00000331483_MYO6_chr6_76595721_ENST00000369977_length(transcript)=5645nt_BP=2603nt GTGTCCAATCCGAGAGCGGCAAAGACGAGCCTCGAAGTCCGCCGGCCAATCGAAGGCGGGCCCCAGCGGCGCGTGCGCGCCGCGGCCAGC GCGCGCGGGCGGGGGGGCAGGCGCGCCCCGGACCCAGGATTTATAAAGGCGAGGCCGGGACCGGCGCGCGCTCTCGTCGCCCCCGCTGTC CCGGCGGCGCCAACCGAAGCGCCCCGCCTGATCCGTGTCCGACATGCTGCGCCGCGCTCTGCTGTGCCTGGCCGTGGCCGCCCTGGTGCG CGCCGACGCCCCCGAGGAGGAGGACCACGTCCTGGTGCTGCGGAAAAGCAACTTCGCGGAGGCGCTGGCGGCCCACAAGTACCTGCTGGT GGAGTTCTATGCCCCTTGGTGTGGCCACTGCAAGGCTCTGGCCCCTGAGTATGCCAAAGCCGCTGGGAAGCTGAAGGCAGAAGGTTCCGA GATCAGGTTGGCCAAGGTGGACGCCACGGAGGAGTCTGACCTGGCCCAGCAGTACGGCGTGCGCGGCTATCCCACCATCAAGTTCTTCAG GAATGGAGACACGGCTTCCCCCAAGGAATATACAGCTGGCAGAGAGGCTGATGACATCGTGAACTGGCTGAAGAAGCGCACGGGCCCGGC TGCCACCACCCTGCCTGACGGCGCAGCTGCAGAGTCCTTGGTGGAGTCCAGCGAGGTGGCTGTCATCGGCTTCTTCAAGGACGTGGAGTC GGACTCTGCCAAGCAGTTTTTGCAGGCAGCAGAGGCCATCGATGACATACCATTTGGGATCACTTCCAACAGTGACGTGTTCTCCAAATA CCAGCTCGACAAAGATGGGGTTGTCCTCTTTAAGAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGAGAACCTGCT GGACTTTATCAAACACAACCAGCTGCCCCTTGTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAATCAAGACTCA CATCCTGCTGTTCTTGCCCAAGAGTGTGTCTGACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAAGGGCAAGAT CCTGTTCATCTTCATCGACAGCGACCACACCGACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCCGGCCGTGCG CCTCATCACCCTGGAGGAGGAGATGACCAAGTACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTGCCACCGCTT CCTGGAGGGCAAAATCAAGCCCCACCTGATGAGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGTTGGGAAGAA CTTTGAAGACGTGGCTTTTGATGAGAAAAAAAACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAGTTGGCTCCCAT TTGGGATAAACTGGGAGAGACGTACAAGGACCATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGAGGCCGTCAA AGTGCACAGCTTCCCCACACTCAAGTTCTTTCCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACGCTGGATGGTTT TAAGAAATTCCTGGAGAGCGGTGGCCAGGATGGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAGCCAGACATGGA GGAAGACGATGATCAGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGCTGCCGAGACCCCTCGGGGGCTGCACAC CCAGCAGCAGCGCACGCCTCCGAAGCCTGCGGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTCTCTGAAGTGACACCTC ACCCCTACACACCGTCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAGGCAGCCCACCCTGGTG GGGCTTGTTTCCTGAAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGAGTCTCGCTGCCTCCCT CCCGCGGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATTTGTTCCACCTTGGCCA GGCCTCCTCGGAGAAGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCTGCAGTGTCGCCATGAC TGATCATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCATGCCTGGAAGAGGAGCTGGTGGCTGCC AGCCCTGGGGCCCGGCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCATTGTGACCACTGGCCT CTCTACAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGGATGCTGGAGCTGAATC AGACGCTGACAGTTCTTCAGGCATTTCTATTTCACAATCGAATTGAACACATTGGCCAAATAAAGTTGAAATTTTACCACCTGTGAAAAA CAAAATAAAATATCGAGCTGAAGCCTGCATTAAAATGCAAAAAACTATTCGAATGTGGCTTTGCAAGAGGAGACACAAACCTCGCATTGA TGGTCTGGTTAAGGTGGGCACACTGAAAAAACGACTTGATAAATTTAATGAGGTAGTCAGTGTGTTGAAAGATGGAAAACCCGAGATGAA TAAACAGATCAAGAATCTGGAAATTTCTATTGATACTTTGATGGCCAAAATTAAGTCCACTATGATGACGCAGGAACAAATCCAGAAAGA ATATGATGCACTGGTTAAAAGCTCAGAGGAACTCCTCAGTGCATTACAGAAAAAAAAACAGCAGGAAGAGGAAGCAGAAAGGCTGAGGCG TATTCAAGAAGAAATGGAAAAGGAAAGAAAAAGACGTGAAGAAGACGAAAAACGTCGAAGAAAGGAAGAGGAGGAAAGGCGGATGAAACT TGAGATGGAAGCAAAGAGAAAACAAGAAGAAGAAGAGAGAAAGAAAAGGGAAGATGATGAAAAACGCATTCAAGCTGAAGTGGAGGCACA GCTGGCCCGACAGAAGGAGGAGGAATCCCAACAGCAAGCAGTTCTGGAGCAGGAGCGCAGGGACCGGGAGCTGGCCCTGAGGATTGCCCA GAGTGAAGCCGAGCTCATCAGTGATGAGGCCCAGGCCGACCTGGCGCTGCGGAGAAATGATGGAACAAGACCCAAAATGACACCGGAACA AATGGCCAAAGAAATGTCAGAATTTTTGAGTAGAGGTCCTGCTGTACTAGCCACCAAAGCAGCTGCTGGTACTAAGAAATATGATCTTAG TAAATGGAAATATGCAGAACTACGTGATACCATCAATACTTCTTGTGATATTGAGCTCCTGGCAGCTTGCAGAGAAGAATTTCATAGGAG ACTAAAAGTGTATCATGCTTGGAAATCTAAGAACAAGAAGAGAAATACTGAAACAGAGCAACGTGCTCCAAAGTCTGTTACTGATTATGA TTTTGCACCATTTTTGAACAATTCACCTCAGCAAAACCCAGCAGCTCAGATTCCTGCCAGGCAGCGGGAGATTGAAATGAACCGACAGCA ACGCTTCTTCCGCATCCCATTCATCCGCCCTGCCGACCAGTACAAAGACCCTCAGAGTAAGAAAAAAGGCTGGTGGTATGCCCATTTTGA TGGACCATGGATTGCCCGGCAAATGGAACTCCATCCTGACAAGCCACCCATCCTACTTGTGGCTGGTAAGGACGACATGGAGATGTGTGA GCTGAATCTTGAGGAGACTGGCCTGACTCGGAAGCGTGGTGCTGAGATCTTGCCAAGACAGTTTGAAGAAATCTGGGAACGCTGTGGAGG CATCCAGTACCTTCAGAATGCGATTGAGAGCAGACAGGCTCGGCCCACCTATGCAACAGCCATGCTGCAGAGTCTGTTAAAGTAGATGTT GCACACCAGCCTTACAGCTGGGAGCCTTTGCCATGGTACTTAGGTAGGGTGTGTGCCCCCAGATTTAACCATTCCATAATCATGTTAGAG TTACTTCTATAAAGTGAACAGATTTTATTAATCACGGCTTTTGGTGAATTTGTTTAAGGTTAATTATGGTAGCAAATTTTGGACCTAAAC ATTATTTTTCTGTATCCCGCTGTAATTCCCAAAACTCTCATTATTCTCTAACTATTACACATGGGCATATTCTGATGTTTCTCATCCTTT GCCAGAAGACTACCTTACATCCATCGTAATTGTTCTCTAGGAAAAGAGAACTTTTTTCAAAATTCAAAATACTTTTTAAGGATGGCACAG TACCATATAACTGGAGTAATAAAACATGAGCTTACATTCTTACAATAACTAAACCACTTAAAATGATCAAGGCACTAATGTTTTGGTCTG AAAAGCTGTGTACTTTATAGACATTTTCAGACATTTTTGGAAATTTCCATTAAAGGTGGAAAATCTATTTTTTTCCTCCTTTGCAGTGTC TTAGTTTGAATGAAACACTTCGAAGTTCTAGAATTCTAGAAAGAGCCTTAATGTATTTGATGTATTCTGTGATAAGAGGTACTAATAGTA TCCAGCACAGATTTGCTTTTCTTTGCTAGCACAATGTGTGTTGCTGTCAGAATATTCTTTTTATATTCTGTGGAAAAATAAAGGAAATTC AGATTGTTTAAATGCCTAAAAGTTTTGAGATAAGTTTTGTTTCAATTAGAAAAGGAAATAGGTTTTAGGTGGCATAGTGGCTTAACTGGA CTGAATTCAAATATTCTTTCAACTTCATCTCAATAGTGATTTTTGTATCAGAATCTTGTCCAAGTTGTTTCATTGATTTAGTAAGTGTTC TGCTTCCAACATCTTTCTTTTTAAGAAATTCCTAGTGTCTTTTTTGGCCTTTGAGGTTTTGGTAATTGTAGACCTGTTTCATAAGCTTTG TAATTCAGAAATCCTTGTATTTAGTAAGTGCTTGTTTTACATAACTGATAATTTTAAAATGTTTTCTTTGTGTGCTGTTAGTATTGATTC AAATGTCAGCAGCTTTAAGCCTAATATTTATGACTTTCACATTTGGAATTTAAAGACAAAAATACATCAAGGAGTTATGCTGACATAATT CTAAGGAGTTTTGTTGTATTTTAGAATAAAATTATAAAGTAAAATGATTCTCTGTACTGCTTTTTCCCCCAGTTTTTAGAGACCCTAACC TTTGAAATGAAATTCCAGTGATTTCTTTTTTCCCTAGAAAGATTACCTCAGTTAGGGAAGTATTTCCCAGCTGACTAGTGTTTGTGAGCC ACAGACACTGTCTTCAGAATTGCTTCTCTCATGTCTTAGTAGAGAAATATTTATTTATTATGATACATTCAAATGATTGTCAAGTTAAAT TAAATGGTTGTGTCTGTGCTATTGAGAATGCAAATGTGATTATCTTTTGAAGGCTGTATTACTGCATAGCTTCACCCACCCTCGGGTCAT >62142_62142_2_P4HB-MYO6_P4HB_chr17_79801037_ENST00000331483_MYO6_chr6_76595721_ENST00000369977_length(amino acids)=559AA_BP= MLLGVQPPRGLGSARVWLCVLQFIFHSFLIIVFLHVWLLCFFQVLEIVIIPCPILATALQEFLKTIQRAFPVVINDRPVGTGRKELECGE AVHFDGLHLVGSRVHLGDDDVLMVLVRLSQFIPNGSQLFAVTTPWGIELHKDVFFLIKSHVFKVLPNKHLDRLLVPVLRQLLAHQVGLDF ALQEAVAELCDPLCRQLLRFGLVLGHLLLQGDEAHGRALFLLQAKELEDALVVGVVAVDEDEQDLALEALGCCFEVAQFAVIVRHTLGQE QQDVSLDFTSKNLRGCLLGELDDKGQLVVFDKVQQVLLGDLPFKVVPAFIKLLKEDNPIFVELVFGEHVTVGSDPKWYVIDGLCCLQKLL GRVRLHVLEEADDSHLAGLHQGLCSCAVRQGGGSRARALLQPVHDVISLSASCIFLGGSRVSIPEELDGGIAAHAVLLGQVRLLRGVHLG QPDLGTFCLQLPSGFGILRGQSLAVATPRGIELHQQVLVGRQRLREVAFPQHQDVVLLLGGVGAHQGGHGQAQQSAAQHVGHGSGGALRL -------------------------------------------------------------- >62142_62142_3_P4HB-MYO6_P4HB_chr17_79801037_ENST00000331483_MYO6_chr6_76595721_ENST00000369981_length(transcript)=8573nt_BP=2603nt GTGTCCAATCCGAGAGCGGCAAAGACGAGCCTCGAAGTCCGCCGGCCAATCGAAGGCGGGCCCCAGCGGCGCGTGCGCGCCGCGGCCAGC GCGCGCGGGCGGGGGGGCAGGCGCGCCCCGGACCCAGGATTTATAAAGGCGAGGCCGGGACCGGCGCGCGCTCTCGTCGCCCCCGCTGTC CCGGCGGCGCCAACCGAAGCGCCCCGCCTGATCCGTGTCCGACATGCTGCGCCGCGCTCTGCTGTGCCTGGCCGTGGCCGCCCTGGTGCG CGCCGACGCCCCCGAGGAGGAGGACCACGTCCTGGTGCTGCGGAAAAGCAACTTCGCGGAGGCGCTGGCGGCCCACAAGTACCTGCTGGT GGAGTTCTATGCCCCTTGGTGTGGCCACTGCAAGGCTCTGGCCCCTGAGTATGCCAAAGCCGCTGGGAAGCTGAAGGCAGAAGGTTCCGA GATCAGGTTGGCCAAGGTGGACGCCACGGAGGAGTCTGACCTGGCCCAGCAGTACGGCGTGCGCGGCTATCCCACCATCAAGTTCTTCAG GAATGGAGACACGGCTTCCCCCAAGGAATATACAGCTGGCAGAGAGGCTGATGACATCGTGAACTGGCTGAAGAAGCGCACGGGCCCGGC TGCCACCACCCTGCCTGACGGCGCAGCTGCAGAGTCCTTGGTGGAGTCCAGCGAGGTGGCTGTCATCGGCTTCTTCAAGGACGTGGAGTC GGACTCTGCCAAGCAGTTTTTGCAGGCAGCAGAGGCCATCGATGACATACCATTTGGGATCACTTCCAACAGTGACGTGTTCTCCAAATA CCAGCTCGACAAAGATGGGGTTGTCCTCTTTAAGAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGAGAACCTGCT GGACTTTATCAAACACAACCAGCTGCCCCTTGTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAATCAAGACTCA CATCCTGCTGTTCTTGCCCAAGAGTGTGTCTGACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAAGGGCAAGAT CCTGTTCATCTTCATCGACAGCGACCACACCGACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCCGGCCGTGCG CCTCATCACCCTGGAGGAGGAGATGACCAAGTACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTGCCACCGCTT CCTGGAGGGCAAAATCAAGCCCCACCTGATGAGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGTTGGGAAGAA CTTTGAAGACGTGGCTTTTGATGAGAAAAAAAACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAGTTGGCTCCCAT TTGGGATAAACTGGGAGAGACGTACAAGGACCATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGAGGCCGTCAA AGTGCACAGCTTCCCCACACTCAAGTTCTTTCCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACGCTGGATGGTTT TAAGAAATTCCTGGAGAGCGGTGGCCAGGATGGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAGCCAGACATGGA GGAAGACGATGATCAGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGCTGCCGAGACCCCTCGGGGGCTGCACAC CCAGCAGCAGCGCACGCCTCCGAAGCCTGCGGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTCTCTGAAGTGACACCTC ACCCCTACACACCGTCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAGGCAGCCCACCCTGGTG GGGCTTGTTTCCTGAAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGAGTCTCGCTGCCTCCCT CCCGCGGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATTTGTTCCACCTTGGCCA GGCCTCCTCGGAGAAGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCTGCAGTGTCGCCATGAC TGATCATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCATGCCTGGAAGAGGAGCTGGTGGCTGCC AGCCCTGGGGCCCGGCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCATTGTGACCACTGGCCT CTCTACAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGGATGCTGGAGCTGAATC AGACGCTGACAGTTCTTCAGGCATTTCTATTTCACAATCGAATTGAACACATTGGCCAAATAAAGTTGAAATTTTACCACCTGTGAAAAA CAAAATAAAATATCGAGCTGAAGCCTGCATTAAAATGCAAAAAACTATTCGAATGTGGCTTTGCAAGAGGAGACACAAACCTCGCATTGA TGGTCTGGTTAAGGTGGGCACACTGAAAAAACGACTTGATAAATTTAATGAGGTAGTCAGTGTGTTGAAAGATGGAAAACCCGAGATGAA TAAACAGATCAAGAATCTGGAAATTTCTATTGATACTTTGATGGCCAAAATTAAGTCCACTATGATGACGCAGGAACAAATCCAGAAAGA ATATGATGCACTGGTTAAAAGCTCAGAGGAACTCCTCAGTGCATTACAGAAAAAAAAACAGCAGGAAGAGGAAGCAGAAAGGCTGAGGCG TATTCAAGAAGAAATGGAAAAGGAAAGAAAAAGACGTGAAGAAGACGAAAAACGTCGAAGAAAGGAAGAGGAGGAAAGGCGGATGAAACT TGAGATGGAAGCAAAGAGAAAACAAGAAGAAGAAGAGAGAAAGAAAAGGGAAGATGATGAAAAACGCATTCAAGCTGAAGTGGAGGCACA GCTGGCCCGACAGAAGGAGGAGGAATCCCAACAGCAAGCAGTTCTGGAGCAGGAGCGCAGGGACCGGGAGCTGGCCCTGAGGATTGCCCA GAGTGAAGCCGAGCTCATCAGTGATGAGGCCCAGGCCGACCTGGCGCTGCGGAGGTACTTGGATTCCTATCCGGTAACTTCTAAAAATGA TGGAACAAGACCCAAAATGACACCGGAACAAATGGCCAAAGAAATGTCAGAATTTTTGAGTAGAGGTCCTGCTGTACTAGCCACCAAAGC AGCTGCTGGTACTAAGAAATATGATCTTAGTAAATGGAAATATGCAGAACTACGTGATACCATCAATACTTCTTGTGATATTGAGCTCCT GGCAGCTTGCAGAGAAGAATTTCATAGGAGACTAAAAGTGTATCATGCTTGGAAATCTAAGAACAAGAAGAGAAATACTGAAACAGAGCA ACGTGCTCCAAAGTCTGTTACTGATTATGCTCAGCAAAACCCAGCAGCTCAGATTCCTGCCAGGCAGCGGGAGATTGAAATGAACCGACA GCAACGCTTCTTCCGCATCCCATTCATCCGCCCTGCCGACCAGTACAAAGACCCTCAGAGTAAGAAAAAAGGCTGGTGGTATGCCCATTT TGATGGACCATGGATTGCCCGGCAAATGGAACTCCATCCTGACAAGCCACCCATCCTACTTGTGGCTGGTAAGGACGACATGGAGATGTG TGAGCTGAATCTTGAGGAGACTGGCCTGACTCGGAAGCGTGGTGCTGAGATCTTGCCAAGACAGTTTGAAGAAATCTGGGAACGCTGTGG AGGCATCCAGTACCTTCAGAATGCGATTGAGAGCAGACAGGCTCGGCCCACCTATGCAACAGCCATGCTGCAGAGTCTGTTAAAGTAGAT GTTGCACACCAGCCTTACAGCTGGGAGCCTTTGCCATGGTACTTAGGTAGGGTGTGTGCCCCCAGATTTAACCATTCCATAATCATGTTA GAGTTACTTCTATAAAGTGAACAGATTTTATTAATCACGGCTTTTGGTGAATTTGTTTAAGGTTAATTATGGTAGCAAATTTTGGACCTA AACATTATTTTTCTGTATCCCGCTGTAATTCCCAAAACTCTCATTATTCTCTAACTATTACACATGGGCATATTCTGATGTTTCTCATCC TTTGCCAGAAGACTACCTTACATCCATCGTAATTGTTCTCTAGGAAAAGAGAACTTTTTTCAAAATTCAAAATACTTTTTAAGGATGGCA CAGTACCATATAACTGGAGTAATAAAACATGAGCTTACATTCTTACAATAACTAAACCACTTAAAATGATCAAGGCACTAATGTTTTGGT CTGAAAAGCTGTGTACTTTATAGACATTTTCAGACATTTTTGGAAATTTCCATTAAAGGTGGAAAATCTATTTTTTTCCTCCTTTGCAGT GTCTTAGTTTGAATGAAACACTTCGAAGTTCTAGAATTCTAGAAAGAGCCTTAATGTATTTGATGTATTCTGTGATAAGAGGTACTAATA GTATCCAGCACAGATTTGCTTTTCTTTGCTAGCACAATGTGTGTTGCTGTCAGAATATTCTTTTTATATTCTGTGGAAAAATAAAGGAAA TTCAGATTGTTTAAATGCCTAAAAGTTTTGAGATAAGTTTTGTTTCAATTAGAAAAGGAAATAGGTTTTAGGTGGCATAGTGGCTTAACT GGACTGAATTCAAATATTCTTTCAACTTCATCTCAATAGTGATTTTTGTATCAGAATCTTGTCCAAGTTGTTTCATTGATTTAGTAAGTG TTCTGCTTCCAACATCTTTCTTTTTAAGAAATTCCTAGTGTCTTTTTTGGCCTTTGAGGTTTTGGTAATTGTAGACCTGTTTCATAAGCT TTGTAATTCAGAAATCCTTGTATTTAGTAAGTGCTTGTTTTACATAACTGATAATTTTAAAATGTTTTCTTTGTGTGCTGTTAGTATTGA TTCAAATGTCAGCAGCTTTAAGCCTAATATTTATGACTTTCACATTTGGAATTTAAAGACAAAAATACATCAAGGAGTTATGCTGACATA ATTCTAAGGAGTTTTGTTGTATTTTAGAATAAAATTATAAAGTAAAATGATTCTCTGTACTGCTTTTTCCCCCAGTTTTTAGAGACCCTA ACCTTTGAAATGAAATTCCAGTGATTTCTTTTTTCCCTAGAAAGATTACCTCAGTTAGGGAAGTATTTCCCAGCTGACTAGTGTTTGTGA GCCACAGACACTGTCTTCAGAATTGCTTCTCTCATGTCTTAGTAGAGAAATATTTATTTATTATGATACATTCAAATGATTGTCAAGTTA AATTAAATGGTTGTGTCTGTGCTATTGAGAATGCAAATGTGATTATCTTTTGAAGGCTGTATTACTGCATAGCTTCACCCACCCTCGGGT CATTTCGTCCCTGTGATTGGGGACAGAAGGTGTAGCTACTGAAGTAAATGACCTATTCTCTCTCTTCCATCTCTCGCCTTTAACTGGTGT TTTTATTTGTGTAGGATAGTGAATGATAAGCTTTTTTCCTAACCAGTAGTGAGTAAAGTTCTTGAACAAAATTTAGTAGCCAAATTGTTT TTTAATGACATGTCTCTTTAGTACAATAGTTTTGTGTATCTTTTAGATACATTAATAGGCACTAGATGGAAAATTAAAGAGTTAAACATA TTTAAATGAGAGAATCTAATGTTTCAGAAATTTGTAAGAAATGTATCACAGCAAAGGGTTGTTATAAGTCCTTAGTTTTTGACTCTAATA GTTAATACAATTATAGTTAATCTTAAGCCATAATGTTTCTAATCATGTCACACAGCTGTCCTAGAACTTATCTATTTAAAATAGTTTCCT GAGTTAATTTTGGCCAGCAGGGCAACTGCCCTAATTCAGATAGATTTACAGTAACCTACGTACAGTAGATGCACATACACACAGACACCC CTTTGCTGGAGAAACTTAGGACCCTGTCAGCCTTTTAAAGGAAACAGCAGGAGTGGTGTCCTAAATGATGTTCATGCAGCTGCTTTACCA TGTTCACAGTCAAGCCCATGCATGCCAGGTTAAAACTGTGGAAATCAAAAGTAAATTCACTCATATTTTAATCATTTTAACTGAGATTTA AAATTAGAAGTTTAAACCACTATATATAAAGAACTAATCTTTTCTTAATACCAGTTCTTTCCATAGCATATGCTTTGCAAAGGCAGCATG CATAAAATATTTAAAATGAGAGGACAGAATGTTTTCACATTTGATTCAATTTTAATATAATTCCTAATTGTGGTAACACAGTTGAGATAT GTATTATGAGTTATGGGAACTAATTGAGAAAAGGAAGTTACTCTAATCCACGTATGTTAAGAGAATATTGAGTTTTCTTAGTTGTAAAGT TGGGGAGATGGCACCTTCTCAGAGGATTGTGAAAATATGAGGAAGAAACAAAACAGTGCATGTAGGAGCACAGGGCCACACAAAGGCATT CTATTGTTATGCTCATTCTGCTTCTGTAATGACTTTTCATAGGTCATTCTTGTGAACCATTTTGTTTTGCAAGCAACCAAGGAAAGAACA TCTTAAGTGGAAAATCAGTGGTGGTTGTGAACACTTAGAGAATAGCAATCCACAGGCAAGAATAATGGTATTGTTTGTAGAGCTTTATTA ATTGGATATTTTTTAAAAGACATTTTCATTCACAGGTCATTACTATGGTTCTCAGCGATCCAAATATGTAGATCATTGGTTTTTTTTTTT ACCTGAAGTAGCTTAAGAGTACTTGGATCAGTAGAATAAATATTTATTGAATCAATCAGTCAGCCAATTAATATGATGTTAGTGATAGAC CTGCCTCCTTTTATGGAAGAGGTAACAGATCCAGAGAGGTCAAGTAATTTAGTTGTAGACTGAAAAATATATCAAAGCCTTTGCTGCAAT CATATGTAACAAAAAGAACCAAAACAAACACTTTTTAGTGGCACCTGTGGATTTACAAAGGGTTGCCTCTCTGTCATTCCACAACTTCAG AAGGTGTGACAGGTTTTCCCTATTTATCATTACCAATAATAACAAGTATTGAGAGTTTTAAAATTTCTCCCAGAAGATAAACTAACAAGG ATGGAAGGGGAGGGCAAAGGATATCTAAACATGAGAATAAGGACATGTTAGAGGGGGGGAAACAGTTGTAACAATAAGGAAAGAGAAGAG CAACAGTGGAAGAGACAGGTTGTGTGCCCCTAAAGATTCTGCACCCCCAGTTTGGAAACACTGATACATTTTAGGACACAGAGCACTCCT AGATCTCTACGAAATTTTAGAATGAATAATGTGTAATTTATAGGATCAGAACGTATGGTTATTAAAACTTGGATCAAGATATGCCCGGTG TATACATTCTTAGCACATAGGAATGGCACTGCCATACTGGAGAAGGTCAGCAGTAAATAGGCATTCTGTACATAAGCCTCATGGAAGGGT AAGATGGAGAGACTGGCAGAAGTAGCACCTACTCTGCTGGGAGCACTTCTCTGAGTACGCTTTAGTTCAATTCAAATCACTGTATTCTTT CCCCATTGCTAACCTAATATATGAAACAAGCTTAGCTGTCTCAGAAGTTTTTCAAGAGATGATCAGGAAAAATTAATGCACATTCAAAAG GAGAATCTTCAGTACAAATTTGTTTTTTTAAAAATAGATTTAGGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGC CGAGGCGGGTGGATCACGAGGTCAAGACTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAACATTAGC CAGGCGTGGTAGTGGGTGCCTGTAATCCCTGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACGCGGGAGGCAGAGGTTGCAGGGA GCCGAGATGGCGCCATTGCACTCCATCCTGGGCAACAAGAGCGAAATTCCATCTCAAAAAATAAAATAGATTTAGGGGGTACAAGTGCAG TTTTGTTACATGGGTATATTGCATAGTGGTAAAATGTGGGCTTTTAGTGTACCTAACACCCAGAGAAGCATACATTGTGCCCAGTAGGTA ATTTTTCATCCCTAAACCTTTTCTCAGCCTCCCACTTTCTGGAGTCTCCAATGTCGGTTATTCCACTCTTTATGTCCATATCTACACATT CAATCCTAATTTGTACCAAGTAGCATCTCACCTTTAAATCACAGGCTTATTAGTTGGGTGTTTTCTTTTTACTTATGAAAATTCATCTAG TCAAACTGTCAATTAATTTTTCCTCATTTCATTAAAAGTGTATATCTAATGCTTTCTCTAAAAATTGATGTACTGGAAATACAAATAAAT >62142_62142_3_P4HB-MYO6_P4HB_chr17_79801037_ENST00000331483_MYO6_chr6_76595721_ENST00000369981_length(amino acids)=559AA_BP= MLLGVQPPRGLGSARVWLCVLQFIFHSFLIIVFLHVWLLCFFQVLEIVIIPCPILATALQEFLKTIQRAFPVVINDRPVGTGRKELECGE AVHFDGLHLVGSRVHLGDDDVLMVLVRLSQFIPNGSQLFAVTTPWGIELHKDVFFLIKSHVFKVLPNKHLDRLLVPVLRQLLAHQVGLDF ALQEAVAELCDPLCRQLLRFGLVLGHLLLQGDEAHGRALFLLQAKELEDALVVGVVAVDEDEQDLALEALGCCFEVAQFAVIVRHTLGQE QQDVSLDFTSKNLRGCLLGELDDKGQLVVFDKVQQVLLGDLPFKVVPAFIKLLKEDNPIFVELVFGEHVTVGSDPKWYVIDGLCCLQKLL GRVRLHVLEEADDSHLAGLHQGLCSCAVRQGGGSRARALLQPVHDVISLSASCIFLGGSRVSIPEELDGGIAAHAVLLGQVRLLRGVHLG QPDLGTFCLQLPSGFGILRGQSLAVATPRGIELHQQVLVGRQRLREVAFPQHQDVVLLLGGVGAHQGGHGQAQQSAAQHVGHGSGGALRL -------------------------------------------------------------- >62142_62142_4_P4HB-MYO6_P4HB_chr17_79801037_ENST00000331483_MYO6_chr6_76595721_ENST00000369985_length(transcript)=8500nt_BP=2603nt GTGTCCAATCCGAGAGCGGCAAAGACGAGCCTCGAAGTCCGCCGGCCAATCGAAGGCGGGCCCCAGCGGCGCGTGCGCGCCGCGGCCAGC GCGCGCGGGCGGGGGGGCAGGCGCGCCCCGGACCCAGGATTTATAAAGGCGAGGCCGGGACCGGCGCGCGCTCTCGTCGCCCCCGCTGTC CCGGCGGCGCCAACCGAAGCGCCCCGCCTGATCCGTGTCCGACATGCTGCGCCGCGCTCTGCTGTGCCTGGCCGTGGCCGCCCTGGTGCG CGCCGACGCCCCCGAGGAGGAGGACCACGTCCTGGTGCTGCGGAAAAGCAACTTCGCGGAGGCGCTGGCGGCCCACAAGTACCTGCTGGT GGAGTTCTATGCCCCTTGGTGTGGCCACTGCAAGGCTCTGGCCCCTGAGTATGCCAAAGCCGCTGGGAAGCTGAAGGCAGAAGGTTCCGA GATCAGGTTGGCCAAGGTGGACGCCACGGAGGAGTCTGACCTGGCCCAGCAGTACGGCGTGCGCGGCTATCCCACCATCAAGTTCTTCAG GAATGGAGACACGGCTTCCCCCAAGGAATATACAGCTGGCAGAGAGGCTGATGACATCGTGAACTGGCTGAAGAAGCGCACGGGCCCGGC TGCCACCACCCTGCCTGACGGCGCAGCTGCAGAGTCCTTGGTGGAGTCCAGCGAGGTGGCTGTCATCGGCTTCTTCAAGGACGTGGAGTC GGACTCTGCCAAGCAGTTTTTGCAGGCAGCAGAGGCCATCGATGACATACCATTTGGGATCACTTCCAACAGTGACGTGTTCTCCAAATA CCAGCTCGACAAAGATGGGGTTGTCCTCTTTAAGAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGAGAACCTGCT GGACTTTATCAAACACAACCAGCTGCCCCTTGTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAATCAAGACTCA CATCCTGCTGTTCTTGCCCAAGAGTGTGTCTGACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAAGGGCAAGAT CCTGTTCATCTTCATCGACAGCGACCACACCGACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCCGGCCGTGCG CCTCATCACCCTGGAGGAGGAGATGACCAAGTACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTGCCACCGCTT CCTGGAGGGCAAAATCAAGCCCCACCTGATGAGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGTTGGGAAGAA CTTTGAAGACGTGGCTTTTGATGAGAAAAAAAACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAGTTGGCTCCCAT TTGGGATAAACTGGGAGAGACGTACAAGGACCATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGAGGCCGTCAA AGTGCACAGCTTCCCCACACTCAAGTTCTTTCCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACGCTGGATGGTTT TAAGAAATTCCTGGAGAGCGGTGGCCAGGATGGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAGCCAGACATGGA GGAAGACGATGATCAGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGCTGCCGAGACCCCTCGGGGGCTGCACAC CCAGCAGCAGCGCACGCCTCCGAAGCCTGCGGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTCTCTGAAGTGACACCTC ACCCCTACACACCGTCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAGGCAGCCCACCCTGGTG GGGCTTGTTTCCTGAAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGAGTCTCGCTGCCTCCCT CCCGCGGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATTTGTTCCACCTTGGCCA GGCCTCCTCGGAGAAGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCTGCAGTGTCGCCATGAC TGATCATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCATGCCTGGAAGAGGAGCTGGTGGCTGCC AGCCCTGGGGCCCGGCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCATTGTGACCACTGGCCT CTCTACAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGGATGCTGGAGCTGAATC AGACGCTGACAGTTCTTCAGGCATTTCTATTTCACAATCGAATTGAACACATTGGCCAAATAAAGTTGAAATTTTACCACCTGTGAAAAA CAAAATAAAATATCGAGCTGAAGCCTGCATTAAAATGCAAAAAACTATTCGAATGTGGCTTTGCAAGAGGAGACACAAACCTCGCATTGA TGGTCTGGTTAAGGTGGGCACACTGAAAAAACGACTTGATAAATTTAATGAGGTAGTCAGTGTGTTGAAAGATGGAAAACCCGAGATGAA TAAACAGATCAAGAATCTGGAAATTTCTATTGATACTTTGATGGCCAAAATTAAGTCCACTATGATGACGCAGGAACAAATCCAGAAAGA ATATGATGCACTGGTTAAAAGCTCAGAGGAACTCCTCAGTGCATTACAGAAAAAAAAACAGCAGGAAGAGGAAGCAGAAAGGCTGAGGCG TATTCAAGAAGAAATGGAAAAGGAAAGAAAAAGACGTGAAGAAGACGAAAAACGTCGAAGAAAGGAAGAGGAGGAAAGGCGGATGAAACT TGAGATGGAAGCAAAGAGAAAACAAGAAGAAGAAGAGAGAAAGAAAAGGGAAGATGATGAAAAACGCATTCAAGCTGAAGTGGAGGCACA GCTGGCCCGACAGAAGGAGGAGGAATCCCAACAGCAAGCAGTTCTGGAGCAGGAGCGCAGGGACCGGGAGCTGGCCCTGAGGATTGCCCA GAGTGAAGCCGAGCTCATCAGTGATGAGGCCCAGGCCGACCTGGCGCTGCGGAGAGGTCCTGCTGTACTAGCCACCAAAGCAGCTGCTGG TACTAAGAAATATGATCTTAGTAAATGGAAATATGCAGAACTACGTGATACCATCAATACTTCTTGTGATATTGAGCTCCTGGCAGCTTG CAGAGAAGAATTTCATAGGAGACTAAAAGTGTATCATGCTTGGAAATCTAAGAACAAGAAGAGAAATACTGAAACAGAGCAACGTGCTCC AAAGTCTGTTACTGATTATGATTTTGCACCATTTTTGAACAATTCACCTCAGCAAAACCCAGCAGCTCAGATTCCTGCCAGGCAGCGGGA GATTGAAATGAACCGACAGCAACGCTTCTTCCGCATCCCATTCATCCGCCCTGCCGACCAGTACAAAGACCCTCAGAGTAAGAAAAAAGG CTGGTGGTATGCCCATTTTGATGGACCATGGATTGCCCGGCAAATGGAACTCCATCCTGACAAGCCACCCATCCTACTTGTGGCTGGTAA GGACGACATGGAGATGTGTGAGCTGAATCTTGAGGAGACTGGCCTGACTCGGAAGCGTGGTGCTGAGATCTTGCCAAGACAGTTTGAAGA AATCTGGGAACGCTGTGGAGGCATCCAGTACCTTCAGAATGCGATTGAGAGCAGACAGGCTCGGCCCACCTATGCAACAGCCATGCTGCA GAGTCTGTTAAAGTAGATGTTGCACACCAGCCTTACAGCTGGGAGCCTTTGCCATGGTACTTAGGTAGGGTGTGTGCCCCCAGATTTAAC CATTCCATAATCATGTTAGAGTTACTTCTATAAAGTGAACAGATTTTATTAATCACGGCTTTTGGTGAATTTGTTTAAGGTTAATTATGG TAGCAAATTTTGGACCTAAACATTATTTTTCTGTATCCCGCTGTAATTCCCAAAACTCTCATTATTCTCTAACTATTACACATGGGCATA TTCTGATGTTTCTCATCCTTTGCCAGAAGACTACCTTACATCCATCGTAATTGTTCTCTAGGAAAAGAGAACTTTTTTCAAAATTCAAAA TACTTTTTAAGGATGGCACAGTACCATATAACTGGAGTAATAAAACATGAGCTTACATTCTTACAATAACTAAACCACTTAAAATGATCA AGGCACTAATGTTTTGGTCTGAAAAGCTGTGTACTTTATAGACATTTTCAGACATTTTTGGAAATTTCCATTAAAGGTGGAAAATCTATT TTTTTCCTCCTTTGCAGTGTCTTAGTTTGAATGAAACACTTCGAAGTTCTAGAATTCTAGAAAGAGCCTTAATGTATTTGATGTATTCTG TGATAAGAGGTACTAATAGTATCCAGCACAGATTTGCTTTTCTTTGCTAGCACAATGTGTGTTGCTGTCAGAATATTCTTTTTATATTCT GTGGAAAAATAAAGGAAATTCAGATTGTTTAAATGCCTAAAAGTTTTGAGATAAGTTTTGTTTCAATTAGAAAAGGAAATAGGTTTTAGG TGGCATAGTGGCTTAACTGGACTGAATTCAAATATTCTTTCAACTTCATCTCAATAGTGATTTTTGTATCAGAATCTTGTCCAAGTTGTT TCATTGATTTAGTAAGTGTTCTGCTTCCAACATCTTTCTTTTTAAGAAATTCCTAGTGTCTTTTTTGGCCTTTGAGGTTTTGGTAATTGT AGACCTGTTTCATAAGCTTTGTAATTCAGAAATCCTTGTATTTAGTAAGTGCTTGTTTTACATAACTGATAATTTTAAAATGTTTTCTTT GTGTGCTGTTAGTATTGATTCAAATGTCAGCAGCTTTAAGCCTAATATTTATGACTTTCACATTTGGAATTTAAAGACAAAAATACATCA AGGAGTTATGCTGACATAATTCTAAGGAGTTTTGTTGTATTTTAGAATAAAATTATAAAGTAAAATGATTCTCTGTACTGCTTTTTCCCC CAGTTTTTAGAGACCCTAACCTTTGAAATGAAATTCCAGTGATTTCTTTTTTCCCTAGAAAGATTACCTCAGTTAGGGAAGTATTTCCCA GCTGACTAGTGTTTGTGAGCCACAGACACTGTCTTCAGAATTGCTTCTCTCATGTCTTAGTAGAGAAATATTTATTTATTATGATACATT CAAATGATTGTCAAGTTAAATTAAATGGTTGTGTCTGTGCTATTGAGAATGCAAATGTGATTATCTTTTGAAGGCTGTATTACTGCATAG CTTCACCCACCCTCGGGTCATTTCGTCCCTGTGATTGGGGACAGAAGGTGTAGCTACTGAAGTAAATGACCTATTCTCTCTCTTCCATCT CTCGCCTTTAACTGGTGTTTTTATTTGTGTAGGATAGTGAATGATAAGCTTTTTTCCTAACCAGTAGTGAGTAAAGTTCTTGAACAAAAT TTAGTAGCCAAATTGTTTTTTAATGACATGTCTCTTTAGTACAATAGTTTTGTGTATCTTTTAGATACATTAATAGGCACTAGATGGAAA ATTAAAGAGTTAAACATATTTAAATGAGAGAATCTAATGTTTCAGAAATTTGTAAGAAATGTATCACAGCAAAGGGTTGTTATAAGTCCT TAGTTTTTGACTCTAATAGTTAATACAATTATAGTTAATCTTAAGCCATAATGTTTCTAATCATGTCACACAGCTGTCCTAGAACTTATC TATTTAAAATAGTTTCCTGAGTTAATTTTGGCCAGCAGGGCAACTGCCCTAATTCAGATAGATTTACAGTAACCTACGTACAGTAGATGC ACATACACACAGACACCCCTTTGCTGGAGAAACTTAGGACCCTGTCAGCCTTTTAAAGGAAACAGCAGGAGTGGTGTCCTAAATGATGTT CATGCAGCTGCTTTACCATGTTCACAGTCAAGCCCATGCATGCCAGGTTAAAACTGTGGAAATCAAAAGTAAATTCACTCATATTTTAAT CATTTTAACTGAGATTTAAAATTAGAAGTTTAAACCACTATATATAAAGAACTAATCTTTTCTTAATACCAGTTCTTTCCATAGCATATG CTTTGCAAAGGCAGCATGCATAAAATATTTAAAATGAGAGGACAGAATGTTTTCACATTTGATTCAATTTTAATATAATTCCTAATTGTG GTAACACAGTTGAGATATGTATTATGAGTTATGGGAACTAATTGAGAAAAGGAAGTTACTCTAATCCACGTATGTTAAGAGAATATTGAG TTTTCTTAGTTGTAAAGTTGGGGAGATGGCACCTTCTCAGAGGATTGTGAAAATATGAGGAAGAAACAAAACAGTGCATGTAGGAGCACA GGGCCACACAAAGGCATTCTATTGTTATGCTCATTCTGCTTCTGTAATGACTTTTCATAGGTCATTCTTGTGAACCATTTTGTTTTGCAA GCAACCAAGGAAAGAACATCTTAAGTGGAAAATCAGTGGTGGTTGTGAACACTTAGAGAATAGCAATCCACAGGCAAGAATAATGGTATT GTTTGTAGAGCTTTATTAATTGGATATTTTTTAAAAGACATTTTCATTCACAGGTCATTACTATGGTTCTCAGCGATCCAAATATGTAGA TCATTGGTTTTTTTTTTTACCTGAAGTAGCTTAAGAGTACTTGGATCAGTAGAATAAATATTTATTGAATCAATCAGTCAGCCAATTAAT ATGATGTTAGTGATAGACCTGCCTCCTTTTATGGAAGAGGTAACAGATCCAGAGAGGTCAAGTAATTTAGTTGTAGACTGAAAAATATAT CAAAGCCTTTGCTGCAATCATATGTAACAAAAAGAACCAAAACAAACACTTTTTAGTGGCACCTGTGGATTTACAAAGGGTTGCCTCTCT GTCATTCCACAACTTCAGAAGGTGTGACAGGTTTTCCCTATTTATCATTACCAATAATAACAAGTATTGAGAGTTTTAAAATTTCTCCCA GAAGATAAACTAACAAGGATGGAAGGGGAGGGCAAAGGATATCTAAACATGAGAATAAGGACATGTTAGAGGGGGGGAAACAGTTGTAAC AATAAGGAAAGAGAAGAGCAACAGTGGAAGAGACAGGTTGTGTGCCCCTAAAGATTCTGCACCCCCAGTTTGGAAACACTGATACATTTT AGGACACAGAGCACTCCTAGATCTCTACGAAATTTTAGAATGAATAATGTGTAATTTATAGGATCAGAACGTATGGTTATTAAAACTTGG ATCAAGATATGCCCGGTGTATACATTCTTAGCACATAGGAATGGCACTGCCATACTGGAGAAGGTCAGCAGTAAATAGGCATTCTGTACA TAAGCCTCATGGAAGGGTAAGATGGAGAGACTGGCAGAAGTAGCACCTACTCTGCTGGGAGCACTTCTCTGAGTACGCTTTAGTTCAATT CAAATCACTGTATTCTTTCCCCATTGCTAACCTAATATATGAAACAAGCTTAGCTGTCTCAGAAGTTTTTCAAGAGATGATCAGGAAAAA TTAATGCACATTCAAAAGGAGAATCTTCAGTACAAATTTGTTTTTTTAAAAATAGATTTAGGGCTGGGCGCGGTGGCTCACGCCTGTAAT CCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTCAAGACTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTA AAAATACAAAACATTAGCCAGGCGTGGTAGTGGGTGCCTGTAATCCCTGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACGCGGG AGGCAGAGGTTGCAGGGAGCCGAGATGGCGCCATTGCACTCCATCCTGGGCAACAAGAGCGAAATTCCATCTCAAAAAATAAAATAGATT TAGGGGGTACAAGTGCAGTTTTGTTACATGGGTATATTGCATAGTGGTAAAATGTGGGCTTTTAGTGTACCTAACACCCAGAGAAGCATA CATTGTGCCCAGTAGGTAATTTTTCATCCCTAAACCTTTTCTCAGCCTCCCACTTTCTGGAGTCTCCAATGTCGGTTATTCCACTCTTTA TGTCCATATCTACACATTCAATCCTAATTTGTACCAAGTAGCATCTCACCTTTAAATCACAGGCTTATTAGTTGGGTGTTTTCTTTTTAC TTATGAAAATTCATCTAGTCAAACTGTCAATTAATTTTTCCTCATTTCATTAAAAGTGTATATCTAATGCTTTCTCTAAAAATTGATGTA >62142_62142_4_P4HB-MYO6_P4HB_chr17_79801037_ENST00000331483_MYO6_chr6_76595721_ENST00000369985_length(amino acids)=559AA_BP= MLLGVQPPRGLGSARVWLCVLQFIFHSFLIIVFLHVWLLCFFQVLEIVIIPCPILATALQEFLKTIQRAFPVVINDRPVGTGRKELECGE AVHFDGLHLVGSRVHLGDDDVLMVLVRLSQFIPNGSQLFAVTTPWGIELHKDVFFLIKSHVFKVLPNKHLDRLLVPVLRQLLAHQVGLDF ALQEAVAELCDPLCRQLLRFGLVLGHLLLQGDEAHGRALFLLQAKELEDALVVGVVAVDEDEQDLALEALGCCFEVAQFAVIVRHTLGQE QQDVSLDFTSKNLRGCLLGELDDKGQLVVFDKVQQVLLGDLPFKVVPAFIKLLKEDNPIFVELVFGEHVTVGSDPKWYVIDGLCCLQKLL GRVRLHVLEEADDSHLAGLHQGLCSCAVRQGGGSRARALLQPVHDVISLSASCIFLGGSRVSIPEELDGGIAAHAVLLGQVRLLRGVHLG QPDLGTFCLQLPSGFGILRGQSLAVATPRGIELHQQVLVGRQRLREVAFPQHQDVVLLLGGVGAHQGGHGQAQQSAAQHVGHGSGGALRL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for P4HB-MYO6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369977 | 22 | 35 | 1116_1118 | 805.3333333333334 | 1286.0 | OPTN | |
| Tgene | MYO6 | chr17:79801037 | chr6:76595721 | ENST00000369985 | 22 | 33 | 1116_1118 | 805.3333333333334 | 1263.0 | OPTN |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for P4HB-MYO6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for P4HB-MYO6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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