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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PABPC1-RPS23 (FusionGDB2 ID:62220)

Fusion Gene Summary for PABPC1-RPS23

check button Fusion gene summary
Fusion gene informationFusion gene name: PABPC1-RPS23
Fusion gene ID: 62220
HgeneTgene
Gene symbol

PABPC1

RPS23

Gene ID

26986

6228

Gene namepoly(A) binding protein cytoplasmic 1ribosomal protein S23
SynonymsPAB1|PABP|PABP1|PABPC2|PABPL1BTDD|MABAS|MCINS|PAMAS|S23|uS12
Cytomap

8q22.3

5q14.2

Type of geneprotein-codingprotein-coding
Descriptionpolyadenylate-binding protein 1poly(A) binding protein, cytoplasmic 240S ribosomal protein S23homolog of yeast ribosomal protein S28small ribosomal subunit protein uS12
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000522387, ENST00000318607, 
ENST00000519004, ENST00000519596, 
ENST00000503605, ENST00000511844, 
ENST00000510210, ENST00000296674, 
ENST00000507980, ENST00000510019, 
ENST00000512493, 
Fusion gene scores* DoF score31 X 28 X 11=95489 X 8 X 3=216
# samples 379
** MAII scorelog2(37/9548*10)=-4.68960139056546
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PABPC1 [Title/Abstract] AND RPS23 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPABPC1(101730411)-RPS23(81573671), # samples:1
Anticipated loss of major functional domain due to fusion event.PABPC1-RPS23 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PABPC1-RPS23 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PABPC1-RPS23 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PABPC1-RPS23 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PABPC1-RPS23 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePABPC1

GO:2000623

negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

18447585

TgeneRPS23

GO:0002181

cytoplasmic translation

25957688


check buttonFusion gene breakpoints across PABPC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPS23 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315465PABPC1chr8

101730411

-RPS23chr5

81573671

-


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Fusion Gene ORF analysis for PABPC1-RPS23

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000522387ENST00000503605PABPC1chr8

101730411

-RPS23chr5

81573671

-
5CDS-5UTRENST00000522387ENST00000511844PABPC1chr8

101730411

-RPS23chr5

81573671

-
Frame-shiftENST00000522387ENST00000510210PABPC1chr8

101730411

-RPS23chr5

81573671

-
In-frameENST00000522387ENST00000296674PABPC1chr8

101730411

-RPS23chr5

81573671

-
In-frameENST00000522387ENST00000507980PABPC1chr8

101730411

-RPS23chr5

81573671

-
In-frameENST00000522387ENST00000510019PABPC1chr8

101730411

-RPS23chr5

81573671

-
In-frameENST00000522387ENST00000512493PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000318607ENST00000296674PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000318607ENST00000507980PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000318607ENST00000510019PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000318607ENST00000510210PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000318607ENST00000512493PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000519004ENST00000296674PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000519004ENST00000507980PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000519004ENST00000510019PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000519004ENST00000510210PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000519004ENST00000512493PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000519596ENST00000296674PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000519596ENST00000507980PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000519596ENST00000510019PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000519596ENST00000510210PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-3CDSENST00000519596ENST00000512493PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-5UTRENST00000318607ENST00000503605PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-5UTRENST00000318607ENST00000511844PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-5UTRENST00000519004ENST00000503605PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-5UTRENST00000519004ENST00000511844PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-5UTRENST00000519596ENST00000503605PABPC1chr8

101730411

-RPS23chr5

81573671

-
intron-5UTRENST00000519596ENST00000511844PABPC1chr8

101730411

-RPS23chr5

81573671

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000522387PABPC1chr8101730411-ENST00000296674RPS23chr581573671-3786607316711131
ENST00000522387PABPC1chr8101730411-ENST00000512493RPS23chr581573671-1018607316711131
ENST00000522387PABPC1chr8101730411-ENST00000510019RPS23chr581573671-1549607316711131
ENST00000522387PABPC1chr8101730411-ENST00000507980RPS23chr581573671-1408607316711131

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000522387ENST00000296674PABPC1chr8101730411-RPS23chr581573671-0.0113080120.98869205
ENST00000522387ENST00000512493PABPC1chr8101730411-RPS23chr581573671-0.0246880110.975312
ENST00000522387ENST00000510019PABPC1chr8101730411-RPS23chr581573671-0.0116679640.9883321
ENST00000522387ENST00000507980PABPC1chr8101730411-RPS23chr581573671-0.0222020370.977798

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Fusion Genomic Features for PABPC1-RPS23


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PABPC1-RPS23


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:101730411/chr5:81573671)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePABPC1chr8:101730411chr5:81573671ENST00000318607-115495_5010311.0Compositional biasNote=Poly-Ala
HgenePABPC1chr8:101730411chr5:81573671ENST00000318607-11511_890311.0DomainRRM 1
HgenePABPC1chr8:101730411chr5:81573671ENST00000318607-115191_2680311.0DomainRRM 3
HgenePABPC1chr8:101730411chr5:81573671ENST00000318607-115294_3700311.0DomainRRM 4
HgenePABPC1chr8:101730411chr5:81573671ENST00000318607-115542_6190311.0DomainPABC
HgenePABPC1chr8:101730411chr5:81573671ENST00000318607-11599_1750311.0DomainRRM 2
HgenePABPC1chr8:101730411chr5:81573671ENST00000318607-115166_2890311.0RegionNote=CSDE1-binding
HgenePABPC1chr8:101730411chr5:81573671ENST00000318607-115541_6360311.0Region(Microbial infection) Binding to HRSV M2-1 protein


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Fusion Gene Sequence for PABPC1-RPS23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>62220_62220_1_PABPC1-RPS23_PABPC1_chr8_101730411_ENST00000522387_RPS23_chr5_81573671_ENST00000296674_length(transcript)=3786nt_BP=607nt
AAATCTTTTAAAAAACCCCAAAAAAATTTACAAAAAATCCGCGTCTCCCCCGCCGGAGACTTTTATTTTTTTTCTTCCTCTTTTATAAAA
TAACCCGGTGAAGCAGCCGAGACCGACCCGCCCGCCCGCGGCCCCGCAGCAGCTCCAAGAAGGAACCAAGAGACCGAGGCCTTCCCGCTG
CCCGGACCCGACACCGCCACCCTCGCTCCCCGCCGGCAGCCGGCAGCCAGCGGCAGTGGATCGACCCCGTTCTGCGGCCGTTGAGTAGTT
TTCAATTCCGGTCGCGGCCTGTGGCCCTGCGGGCAGCCGTGCCGAGATGAACCCCAGTGCCCCCAGCTACCCCATGGCCTCGCTCTACGT
GGGGGACCTCCACCCCGACGTGACCGAGGCGATGCTCTACGAGAAGTTCAGCCCGGCCGGGCCCATCCTCTCCATCCGGGTCTGCAGGGA
CATGATCACCCGCCGCTCCTTGGGCTACGCGTATGTGAACTTCCAGCAGCCGGCGGACGCGGAGCGTGCTTTGGACACCATGAATTTTGA
TGTTATAAAGGGCAAGCCAGTACGCATCATGTGGTCTCAGCGTGATCCATCACTTCGCAAAAGTGGAGCAAGTGTCGTGGACTTCGTACT
GCTAGGAAGCTCCGTAGTCACCGACGAGACCAGAAGTGGCATGATAAACAGTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGGCCAAC
CCTTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAAGTAGGAGTTGAAGCCAAACAGCCAAATTCTGCCATTAGGAAGTGT
GTAAGGGTCCAGCTGATCAAGAATGGCAAGAAAATCACAGCCTTTGTACCCAATGACGGTTGCTTGAACTTTATTGAGGAAAATGATGAA
GTTCTGGTTGCTGGATTTGGTCGCAAAGGTCATGCTGTTGGTGATATTCCTGGAGTCCGCTTTAAGGTTGTCAAAGTAGCCAATGTTTCT
CTTTTGGCCCTATACAAAGGCAAGAAGGAAAGACCAAGATCATAAATATTAATGGTGAAAACACTGTAGTAATAAATTTTCATATGCCAA
AAAATGTTTGTATCTTACTGTCCCCTGTTCTCACCACGAAGATCATGTTCATTACCACCACCACCCCCCCTTATTTTTTTTATCCTAAAC
CAGCAAACGCAGGACCTGTACCAATTTTAGGAGACAATAAGACAGGGTTGTTTCAGGATTCTCTAGAGTTAATAACATTTGTAACCTGGC
ACAGTTTCCCTCATCCTGTGGAATAAGAAAATGGGATAGATCTGGAATAAATGTGCAGTATTGTAGTATTACTTTAAGAACTTTAAGGGA
ACTTCAAAAACTCACTGAAATTCTAGTGAGATACTTTCTTTTTTATTCTTGGTATTTTCCATATCGGGTGCAACACTTCAGTTACCAAAT
TTCATTGCACATAGATTATCTTAGGTACCCTTGGAAATGCACATTCTTGTATCCATCTTACAGGGGCCCAAGATGATAAATAGTAAACTC
AAAATTGCTCCCCACTCTGTTTATTATTTAAAGGTGTCAGGATCTGTGTTGTAATGTGTCTACATTAATGTGTTTAGGAGAATACAGGCA
TTGGATCATTTAGTTGATGGAAGTATATGCCAGGCAAGGGAGATAAGGTATACGACAAGACTGATGTTTTCAGTATCTTCTCATGAGGTT
GTCAGAGACCTTCATGTCTTCAAAGACTAGTCAGCAAATGAAGTGGTTTAGTGTAGAGACAAGATTGGTTGTGTTTTGATAATTTAAGCT
AGGTATTGAGTACATGTGGATTTTGCTGTCCACAAATACTTGTTTCAGAGTTTTCATGGATACAGTGGCATGGTTGAAATGAAGCTGTGA
GCCTTCTGCTTTAAATCTGATGTAAGAAACTCCTGTTAACAAATAGTAAGTATGGGTTAATTAGCCCTTTGATCAAAGCCTAGCTTTACA
TTGTTTAGGATCTTTGGAAAACAATTGGTTTGGTTGCCCACTTTCCGTAGGATCAAGAGCAGAACCTTTCACATGGCACAGAAGAACCCA
GGTTGCGCTTCATACCTGCATATTCCAGCCTTAGCCTGCCATTTCTCTCCTTGGCACTTTGTGCTCCAGCAACACTGGTCTCAGTTGGTC
ATCCTCAAACTTGGGTTCCATATCCAGCCTCAGGACCTCTGTTCCTGTTACTATGGTTCCTTGCATGTCGCCTGCTCTTACTAAAGAGCT
CGTGTGTTTTCCAGCACACTTCGGTTTATCTCTTGATGATGATGCTAGTCTCTCCCTCCGCAAGGGCGGAAAGGCTGCCTGTTGGTTTGT
ACCAGTGTTTCCTAACGTGTAGCTGCAGTCAGTATTTGGCTAAGCTGTTCCCAGGGGCTCAACAGATGCTTTCGGATGAGCCTTAACTGA
CCCAATCCTTTGTGATGCGGGAGAGATTGCTAGGCCTCGCTCACCTGGCCAGAACCAGGGAAAGAGGCCGCGGTTGCAGCGCGATTCCAG
GCCCTGGGCGTCAGGCGCGGGGTGGGCAGCTCTCCCCGGGCGGTGGGGCCCTTGTGACCGCGAGGCGGGGCGCACCAGGAAGGGAGTGGG
ACAGCGCGGGCGCCCAGGGATGTGGCCTGGTTACCTGCCTTCTCTGATACGTCAAGACACCTTCAACAATGGCTTGCAGCTGTACCCTGT
TGGCTGCACCCAGGACGCCCTTTTCACTGCTAAGCAGTCCTACCTGAGGCCCAGGGGCTGCCAGATTGACCCATAAATAATCTCCGGCGC
CTCAGATCCAGAAGCTGCTGAGCCTGATCTTAGTGCCTTCTCCTTTCTCTGTGTGGCCCCCCAGCCCCTTTCCCCACTGCCTTGTGTCCA
AGGCCCTTTCCTTCATGTATCCATGGAGGAGAGACAAAAATACACATCAATAAAATAAGATAGGGAATCCATAAATAGACATTCAGAAGT
ATGGCCAACGGATTTATCTTAAAACCAATGGAGGAAGAAGAGTTTCAATAAATGTTGTGGACTTCCATTTGTCAAAGACCAAAACAAAGG
AACCCCAACCTTACATGTAATACAAACTTAACTCAAAATGGATCATATATCTAAATGTAAAATGGAAAGCTATAAAACTGAAAACAGACT
ATCTTTACAACCTAGGCGTAGGTATAGTTTTTAGACATTACACCAAAAGCACATGCCGTAAAAGAAAAAATAGATAAATTGGTGGATTTC
ATTAAAATTAAAAAACTTTTTCTCTCTGAAAAATCCTGTTAAGCTGGGCGCTGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGCTG
AGTTGGGAAGAAATTAATAGCTTGAGGCCAGGAGTTCAAGATCATCCTGGGCAGCAAAGTCATACACTCTTGAGGGAAGAGAGAGACCTT
CTCATATTGTTTTATATTGTTTTATACTCAGTACCTGTTTTAAGAAAAAAACAAGGAAGTGAAATCAAAGACAGGCAGCCCGGCACCAGG
CCTGAAACCAGCCCTGGGCCTGCCTGGCCTAAACCTAGTAGTTAAAAATCAACTTACGACTTAGAACCTGATGTTATCCGTAGATTCCAA
GCATTGTATAAAAAAATTGTGAAACTCCCTGTTGTGTTCTGTACCAGTGCATGAAACCCCTGTCACATATCCCCTAGATTGCTCAATCAA
TCACGACCCTTTCATGTGAAATCTTTAGTGTTGTGAGCCCTTAAAAGGGACAGAAATTGTGCACTTGAGGAGCTCAGATTTTAAGGCTGT

>62220_62220_1_PABPC1-RPS23_PABPC1_chr8_101730411_ENST00000522387_RPS23_chr5_81573671_ENST00000296674_length(amino acids)=131AA_BP=97
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRD

--------------------------------------------------------------
>62220_62220_2_PABPC1-RPS23_PABPC1_chr8_101730411_ENST00000522387_RPS23_chr5_81573671_ENST00000507980_length(transcript)=1408nt_BP=607nt
AAATCTTTTAAAAAACCCCAAAAAAATTTACAAAAAATCCGCGTCTCCCCCGCCGGAGACTTTTATTTTTTTTCTTCCTCTTTTATAAAA
TAACCCGGTGAAGCAGCCGAGACCGACCCGCCCGCCCGCGGCCCCGCAGCAGCTCCAAGAAGGAACCAAGAGACCGAGGCCTTCCCGCTG
CCCGGACCCGACACCGCCACCCTCGCTCCCCGCCGGCAGCCGGCAGCCAGCGGCAGTGGATCGACCCCGTTCTGCGGCCGTTGAGTAGTT
TTCAATTCCGGTCGCGGCCTGTGGCCCTGCGGGCAGCCGTGCCGAGATGAACCCCAGTGCCCCCAGCTACCCCATGGCCTCGCTCTACGT
GGGGGACCTCCACCCCGACGTGACCGAGGCGATGCTCTACGAGAAGTTCAGCCCGGCCGGGCCCATCCTCTCCATCCGGGTCTGCAGGGA
CATGATCACCCGCCGCTCCTTGGGCTACGCGTATGTGAACTTCCAGCAGCCGGCGGACGCGGAGCGTGCTTTGGACACCATGAATTTTGA
TGTTATAAAGGGCAAGCCAGTACGCATCATGTGGTCTCAGCGTGATCCATCACTTCGCAAAAGTGGAGCAAGTGTCGTGGACTTCGTACT
GCTAGGAAGCTCCGTAGTCACCGACGAGACCAGAAGTGGCATGATAAACAGTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGGCCAAC
CCTTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAAGTAGGAGTTGAAGCCAAACAGCCAAATTCTGCCATTAGGAAGTGT
GTAAGGGTCCAGCTGATCAAGAATGGCAAGAAAATCACAGCCTTTGTACCCAATGACGGTTGCTTGAACTTTATTGAGGTGAGTATTTCA
ACTCTATCGTACCTTCTGTTCTTGGGGTGGCCTCCCTCACATTTTTATCTGATGCAAGGGAGTTTCCTCACATGAAAGTATTTTTGTGAT
CGCCACCAACACCAGAAATAAACTTCTTATTTTATTCCAGGAAAATGATGAAGTTCTGGTTGCTGGATTTGGTCGCAAAGGTCATGCTGT
TGGTGATATTCCTGGAGTCCGCTTTAAGGTTGTCAAAGTAGCCAATGTTTCTCTTTTGGCCCTATACAAAGGCAAGAAGGAAAGACCAAG
ATCATAAATATTAATGGTGAAAACACTGTAGTAATAAATTTTCATATGCCAAAAAATGTTTGTATCTTACTGTCCCCTGTTCTCACCACG
AAGATCATGTTCATTACCACCACCACCCCCCCTTATTTTTTTTATCCTAAACCAGCAAACGCAGGACCTGTACCAATTTTAGGAGACAAT

>62220_62220_2_PABPC1-RPS23_PABPC1_chr8_101730411_ENST00000522387_RPS23_chr5_81573671_ENST00000507980_length(amino acids)=131AA_BP=97
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRD

--------------------------------------------------------------
>62220_62220_3_PABPC1-RPS23_PABPC1_chr8_101730411_ENST00000522387_RPS23_chr5_81573671_ENST00000510019_length(transcript)=1549nt_BP=607nt
AAATCTTTTAAAAAACCCCAAAAAAATTTACAAAAAATCCGCGTCTCCCCCGCCGGAGACTTTTATTTTTTTTCTTCCTCTTTTATAAAA
TAACCCGGTGAAGCAGCCGAGACCGACCCGCCCGCCCGCGGCCCCGCAGCAGCTCCAAGAAGGAACCAAGAGACCGAGGCCTTCCCGCTG
CCCGGACCCGACACCGCCACCCTCGCTCCCCGCCGGCAGCCGGCAGCCAGCGGCAGTGGATCGACCCCGTTCTGCGGCCGTTGAGTAGTT
TTCAATTCCGGTCGCGGCCTGTGGCCCTGCGGGCAGCCGTGCCGAGATGAACCCCAGTGCCCCCAGCTACCCCATGGCCTCGCTCTACGT
GGGGGACCTCCACCCCGACGTGACCGAGGCGATGCTCTACGAGAAGTTCAGCCCGGCCGGGCCCATCCTCTCCATCCGGGTCTGCAGGGA
CATGATCACCCGCCGCTCCTTGGGCTACGCGTATGTGAACTTCCAGCAGCCGGCGGACGCGGAGCGTGCTTTGGACACCATGAATTTTGA
TGTTATAAAGGGCAAGCCAGTACGCATCATGTGGTCTCAGCGTGATCCATCACTTCGCAAAAGTGGAGCAAGTGTCGTGGACTTCGTACT
GCTAGGAAGCTCCGTAGTCACCGACGAGACCAGAAGTGGCATGATAAACAGTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGGCCAAC
CCTTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAAGTAGGAGTTGAAGCCAAACAGCCAAATTCTGCCATTAGGAAGTGT
GTAAGGGTCCAGCTGATCAAGAATGGCAAGAAGGAAAGACCAAGATCATAAATATTAATGGTGAAAACACTGTAGTAATAAATTTTCATA
TGCCAAAAAATGTTTGTATCTTACTGTCCCCTGTTCTCACCACGAAGATCATGTTCATTACCACCACCACCCCCCCTTATTTTTTTTATC
CTAAACCAGCAAACGCAGGACCTGTACCAATTTTAGGAGACAATAAGACAGGGTTGTTTCAGGATTCTCTAGAGTTAATAACATTTGTAA
CCTGGCACAGTTTCCCTCATCCTGTGGAATAAGAAAATGGGATAGATCTGGAATAAATGTGCAGTATTGTAGTATTACTTTAAGAACTTT
AAGGGAACTTCAAAAACTCACTGAAATTCTAGTGAGATACTTTCTTTTTTATTCTTGGTATTTTCCATATCGGGTGCAACACTTCAGTTA
CCAAATTTCATTGCACATAGATTATCTTAGGTACCCTTGGAAATGCACATTCTTGTATCCATCTTACAGGGGCCCAAGATGATAAATAGT
AAACTCAAAATTGCTCCCCACTCTGTTTATTATTTAAAGGTGTCAGGATCTGTGTTGTAATGTGTCTACATTAATGTGTTTAGGAGAATA
CAGGCATTGGATCATTTAGTTGATGGAAGTATATGCCAGGCAAGGGAGATAAGGTATACGACAAGACTGATGTTTTCAGTATCTTCTCAT

>62220_62220_3_PABPC1-RPS23_PABPC1_chr8_101730411_ENST00000522387_RPS23_chr5_81573671_ENST00000510019_length(amino acids)=131AA_BP=97
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRD

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>62220_62220_4_PABPC1-RPS23_PABPC1_chr8_101730411_ENST00000522387_RPS23_chr5_81573671_ENST00000512493_length(transcript)=1018nt_BP=607nt
AAATCTTTTAAAAAACCCCAAAAAAATTTACAAAAAATCCGCGTCTCCCCCGCCGGAGACTTTTATTTTTTTTCTTCCTCTTTTATAAAA
TAACCCGGTGAAGCAGCCGAGACCGACCCGCCCGCCCGCGGCCCCGCAGCAGCTCCAAGAAGGAACCAAGAGACCGAGGCCTTCCCGCTG
CCCGGACCCGACACCGCCACCCTCGCTCCCCGCCGGCAGCCGGCAGCCAGCGGCAGTGGATCGACCCCGTTCTGCGGCCGTTGAGTAGTT
TTCAATTCCGGTCGCGGCCTGTGGCCCTGCGGGCAGCCGTGCCGAGATGAACCCCAGTGCCCCCAGCTACCCCATGGCCTCGCTCTACGT
GGGGGACCTCCACCCCGACGTGACCGAGGCGATGCTCTACGAGAAGTTCAGCCCGGCCGGGCCCATCCTCTCCATCCGGGTCTGCAGGGA
CATGATCACCCGCCGCTCCTTGGGCTACGCGTATGTGAACTTCCAGCAGCCGGCGGACGCGGAGCGTGCTTTGGACACCATGAATTTTGA
TGTTATAAAGGGCAAGCCAGTACGCATCATGTGGTCTCAGCGTGATCCATCACTTCGCAAAAGTGGAGCAAGTGTCGTGGACTTCGTACT
GCTAGGAAGCTCCGTAGTCACCGACGAGACCAGAAGTGGCATGATAAACAGTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGGCCAAC
CCTTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAAGTAGGAGTTGAAGCCAAACAGCCAAATTCTGCCATTAGGAAGTGT
GTAAGGGTCCAGCTGATCAAGAATGGCAAGAAAATCACAGCCTTTGTACCCAATGACGGTTGCTTGAACTTTATTGAGGAAAATGATGAA
GTTCTGGTTGCTGGATTTGGTCGCAAAGGTCATGCTGTTGGTGATATTCCTGGAGTCCGCTTTAAGAGTTTTCATGGATACAGTGGCATG

>62220_62220_4_PABPC1-RPS23_PABPC1_chr8_101730411_ENST00000522387_RPS23_chr5_81573671_ENST00000512493_length(amino acids)=131AA_BP=97
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRD

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Fusion Gene PPI Analysis for PABPC1-RPS23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PABPC1-RPS23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PABPC1-RPS23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource