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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PACS2-DSG2 (FusionGDB2 ID:62267)

Fusion Gene Summary for PACS2-DSG2

Fusion gene summary

Fusion gene information	Fusion gene name: PACS2-DSG2
	Fusion gene ID: 62267
		Hgene	Tgene
	Gene symbol	PACS2	DSG2
	Gene ID	23241	1829
	Gene name	phosphofurin acidic cluster sorting protein 2	desmoglein 2
	Synonyms	EIEE66\|PACS-2\|PACS1L	CDHF5\|HDGC
	Cytomap	14q32.33	18q12.1
	Type of gene	protein-coding	protein-coding
	Description	phosphofurin acidic cluster sorting protein 2PACS1-like protein	desmoglein-2cadherin family member 5
	Modification date	20200313	20200313
	UniProtAcc	.	Q14126
	Ensembl transtripts involved in fusion gene	ENST00000325438, ENST00000430725, ENST00000447393, ENST00000458164, ENST00000547217, ENST00000551743, ENST00000551801,	ENST00000585206, ENST00000261590,
Fusion gene scores	* DoF score	13 X 12 X 6=936	5 X 4 X 2=40
	# samples	14	5
	** MAII score	log2(14/936*10)=-2.74108170263844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: PACS2 [Title/Abstract] AND DSG2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PACS2(105818804)-DSG2(29104666), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PACS2	GO:0000045	autophagosome assembly	23455425
Hgene	PACS2	GO:0034497	protein localization to phagophore assembly site	23455425
Tgene	DSG2	GO:0007155	cell adhesion	17559062
Tgene	DSG2	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	17559062

Fusion gene breakpoints across PACS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DSG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-N5-A4RD-01A	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+
ChimerDB4	UCS	TCGA-N5-A4RD	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+

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Fusion Gene ORF analysis for PACS2-DSG2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000325438	ENST00000585206	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+
5CDS-intron	ENST00000430725	ENST00000585206	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+
5CDS-intron	ENST00000447393	ENST00000585206	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+
5CDS-intron	ENST00000458164	ENST00000585206	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+
In-frame	ENST00000325438	ENST00000261590	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+
In-frame	ENST00000430725	ENST00000261590	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+
In-frame	ENST00000447393	ENST00000261590	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+
In-frame	ENST00000458164	ENST00000261590	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+
intron-3CDS	ENST00000547217	ENST00000261590	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+
intron-3CDS	ENST00000551743	ENST00000261590	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+
intron-3CDS	ENST00000551801	ENST00000261590	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+
intron-intron	ENST00000547217	ENST00000585206	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+
intron-intron	ENST00000551743	ENST00000585206	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+
intron-intron	ENST00000551801	ENST00000585206	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000430725

PACS2

chr14

105818804

ENST00000261590

DSG2

chr18

29104666

5389

595

304

3123

939

ENST00000325438

PACS2

chr14

105818804

ENST00000261590

DSG2

chr18

29104666

5595

801

177

3329

1050

ENST00000458164

PACS2

chr14

105818804

ENST00000261590

DSG2

chr18

29104666

5266

472

175

3000

941

ENST00000447393

PACS2

chr14

105818804

ENST00000261590

DSG2

chr18

29104666

5266

472

175

3000

941

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000430725	ENST00000261590	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+	0.000224686	0.99977535
ENST00000325438	ENST00000261590	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+	0.000263799	0.99973625
ENST00000458164	ENST00000261590	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+	0.000287464	0.9997125
ENST00000447393	ENST00000261590	PACS2	chr14	105818804	+	DSG2	chr18	29104666	+	0.000287464	0.9997125

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Fusion Genomic Features for PACS2-DSG2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PACS2	chr14	105818804	+	DSG2	chr18	29104665	+	0.3828065	0.6171935
PACS2	chr14	105818804	+	DSG2	chr18	29104665	+	0.3828065	0.6171935
PACS2	chr14	105818804	+	DSG2	chr18	29104665	+	0.3828065	0.6171935
PACS2	chr14	105818804	+	DSG2	chr18	29104665	+	0.3828065	0.6171935

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PACS2-DSG2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:105818804/chr18:29104666)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DSG2 Q14126
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DSG2

chr14:105818804

chr18:29104666

ENST00000261590

274_388

276

1119.0

Domain

Cadherin 3

Tgene

DSG2

chr14:105818804

chr18:29104666

ENST00000261590

389_503

276

1119.0

Domain

Cadherin 4

Tgene

DSG2

chr14:105818804

chr18:29104666

ENST00000261590

1022_1051

276

1119.0

Repeat

Note=Desmoglein repeat 6

Tgene

DSG2

chr14:105818804

chr18:29104666

ENST00000261590

881_912

276

1119.0

Repeat

Note=Desmoglein repeat 1

Tgene

DSG2

chr14:105818804

chr18:29104666

ENST00000261590

913_942

276

1119.0

Repeat

Note=Desmoglein repeat 2

Tgene

DSG2

chr14:105818804

chr18:29104666

ENST00000261590

943_968

276

1119.0

Repeat

Note=Desmoglein repeat 3

Tgene

DSG2

chr14:105818804

chr18:29104666

ENST00000261590

969_992

276

1119.0

Repeat

Note=Desmoglein repeat 4

Tgene

DSG2

chr14:105818804

chr18:29104666

ENST00000261590

993_1021

276

1119.0

Repeat

Note=Desmoglein repeat 5

Tgene

DSG2

chr14:105818804

chr18:29104666

ENST00000261590

635_1118

276

1119.0

Topological domain

Cytoplasmic

Tgene

DSG2

chr14:105818804

chr18:29104666

ENST00000261590

610_634

276

1119.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DSG2

chr14:105818804

chr18:29104666

ENST00000261590

161_273

276

1119.0

Domain

Cadherin 2

Tgene

DSG2

chr14:105818804

chr18:29104666

ENST00000261590

50_160

276

1119.0

Domain

Cadherin 1

Tgene

DSG2

chr14:105818804

chr18:29104666

ENST00000261590

50_609

276

1119.0

Topological domain

Extracellular

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Fusion Gene Sequence for PACS2-DSG2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>62267_62267_1_PACS2-DSG2_PACS2_chr14_105818804_ENST00000325438_DSG2_chr18_29104666_ENST00000261590_length(transcript)=5595nt_BP=801nt
GGTGGACCCCCACGACTCTCCCGGCCCTTGCCCGCGGCTCCCGGGGGGCGGGGCGGGGCGCCCCGGGCGGGGTCTGTGCGCAGGCGCGTG
AGTGCGCGCTCTCGCGCACCGGCGGGCGGGGACGCCCCGTGAGGCGCCGCCGGAGGAAGCGCGCGCGCACCTCACTTCCGGCGCGCGCTG
CGCCGGCGGCGATTGGACCCGAGGCGGCGAGCTGGCGCCCCGCCCAGCCAATCGGCGGCGCCGGCGCGGGTCGGAGGGCGCCGGGCGCGC
GCGGGGCGGCCGGGGGCGCGCGGGGCGCGGGCGGGGCGCCGGGCGGGGCGGGGCGGAGCGGCCGCAGCTCGTCGCCGCCCGCGGGCCTGT
CCGACGCCGGGGCCCGGCCCGTCCCCTCCGCCGCCCGGCAGCCATGTGACCGCGCCGCCGCCCTCCGCGCGCCCGGCCCGCCCGCCGCGC
GTCCGCGGCCCGGCCGCAGCCCCAGGCCGCCGAGGGAGCGGCGGGGCCGGCGCCATGGCCGAGCGAGGCCGCCTCGGCCTCCCCGGCGCG
CCCGGCGCGCTCAACACGCCCGTGCCCATGAACCTGTTCGCCACCTGGGAGGTGGACGGCTCCAGCCCCAGCTGCGTGCCCAGGTTGTGC
AGCCTGACTCTGAAGAAGCTGGTGGTCTTCAAGGAGCTGGAGAAGGAGCTGATCTCCGTGGTGATCGCTGTCAAGATGCAGGGCTCCAAA
CGAATCCTGCGGTCCCATGAGATTGTGCTGCCCCCCAGTGGACAAGTGGAGACAGACCTGGCCCTGACCTTCTCCTTGCAGCTTGAAGGG
ATGGTTGAAGAAAATCAAGTCAACGTAGAAGTTACGCGCATAAAAGTGTTCGATGCAGATGAAATAGGTTCTGATAATTGGCTGGCAAAT
TTTACATTTGCATCAGGAAATGAAGGAGGTTATTTCCACATAGAAACAGATGCTCAAACTAACGAAGGAATTGTGACCCTTATTAAGGAA
GTAGATTATGAAGAAATGAAGAATCTTGACTTCAGTGTTATTGTCGCTAATAAAGCAGCTTTTCACAAGTCGATTAGGAGTAAATACAAG
CCTACACCCATTCCCATCAAGGTCAAAGTGAAAAATGTGAAAGAAGGCATTCATTTTAAAAGCAGCGTCATCTCAATTTATGTTAGCGAG
AGCATGGATAGATCAAGCAAAGGCCAAATAATTGGAAATTTTCAAGCTTTTGATGAGGACACTGGACTACCAGCCCATGCAAGATATGTA
AAATTAGAAGATAGAGATAATTGGATCTCTGTGGATTCTGTCACATCTGAAATTAAACTTGCAAAACTTCCTGATTTTGAATCTAGATAT
GTTCAAAATGGCACATACACTGTAAAGATTGTGGCCATATCAGAAGATTATCCTAGAAAAACCATCACTGGCACAGTCCTTATCAATGTT
GAAGACATCAACGACAACTGTCCCACACTGATAGAGCCTGTGCAGACAATCTGTCACGATGCAGAGTATGTGAATGTTACTGCAGAGGAC
CTGGATGGACACCCAAACAGTGGCCCTTTCAGTTTCTCCGTCATTGACAAACCACCTGGCATGGCAGAAAAATGGAAAATAGCACGCCAA
GAAAGTACCAGTGTGCTGCTGCAACAAAGTGAGAAAAAGCTTGGGAGAAGTGAAATTCAGTTCCTGATTTCAGACAATCAGGGTTTTAGT
TGTCCTGAAAAGCAGGTCCTTACACTCACAGTTTGTGAGTGTCTGCATGGCAGCGGCTGCAGGGAAGCACAGCATGACTCCTATGTGGGC
CTGGGACCCGCAGCAATTGCGCTCATGATTTTGGCCTTTCTGCTCCTGCTATTGGTACCACTTTTACTGCTGATGTGCCATTGCGGAAAG
GGCGCCAAAGGCTTTACCCCCATACCTGGCACCATAGAGATGCTGCATCCTTGGAATAATGAAGGAGCACCACCTGAAGACAAGGTGGTG
CCATCATTTCTGCCAGTGGATCAAGGGGGCAGTCTAGTAGGAAGAAATGGAGTAGGAGGTATGGCCAAGGAAGCCACGATGAAAGGAAGT
AGCTCTGCTTCCATTGTCAAAGGGCAACATGAGATGTCCGAGATGGATGGAAGGTGGGAAGAACACAGAAGCCTGCTTTCTGGTAGAGCT
ACCCAGTTTACAGGGGCCACAGGCGCTATCATGACCACTGAAACCACGAAGACCGCAAGGGCCACAGGGGCTTCCAGAGACATGGCCGGA
GCTCAGGCAGCTGCTGTTGCACTGAACGAAGAATTCTTAAGAAATTATTTCACTGATAAAGCGGCCTCTTACACTGAGGAAGATGAAAAT
CACACAGCCAAAGATTGCCTTCTGGTTTATTCTCAGGAAGAAACTGAATCGCTGAATGCTTCTATTGGTTGTTGCAGTTTTATTGAAGGA
GAGCTAGATGACCGCTTCTTAGATGATTTGGGACTTAAATTCAAGACACTAGCTGAAGTTTGCCTGGGTCAAAAAATAGATATAAATAAG
GAAATTGAGCAGAGACAAAAACCTGCCACAGAAACAAGTATGAACACAGCTTCACATTCACTCTGTGAGCAAACTATGGTTAATTCAGAG
AATACCTACTCCTCTGGCAGTAGCTTCCCAGTTCCAAAATCTTTGCAAGAAGCCAATGCAGAGAAAGTAACTCAGGAAATAGTCACTGAA
AGATCTGTGTCTTCTAGGCAGGCGCAAAAGGTAGCTACACCTCTTCCTGACCCAATGGCTTCTAGAAATGTGATAGCAACAGAAACTTCC
TATGTCACAGGGTCCACTATGCCACCAACCACTGTGATCCTGGGTCCTAGCCAGCCACAGAGCCTTATTGTGACAGAGAGGGTGTATGCT
CCAGCTTCTACCTTGGTAGATCAGCCTTATGCTAATGAAGGTACAGTTGTGGTCACTGAAAGAGTAATACAGCCTCATGGGGGTGGATCG
AATCCTCTGGAAGGCACTCAGCATCTTCAAGATGTACCTTACGTCATGGTGAGGGAAAGAGAGAGCTTCCTTGCCCCCAGCTCAGGTGTG
CAGCCTACTCTGGCCATGCCTAATATAGCAGTAGGACAGAATGTGACAGTGACAGAAAGAGTTCTAGCACCTGCTTCCACTCTGCAATCC
AGTTACCAGATTCCCACTGAAAATTCTATGACGGCTAGGAACACCACGGTGTCTGGAGCTGGAGTCCCTGGCCCTCTGCCAGATTTTGGT
TTAGAGGAATCTGGTCATTCTAATTCTACCATAACCACATCTTCCACCAGAGTTACCAAGCATAGCACTGTACAGCATTCTTACTCCTAA
ACAGCAGTCAGCCACAAACTGACCCAGAGTTTAATTAGCAGTGACTAATTTCATGTTTCCAATGTACCTGATTTTTCATGAGCCTTACAG
ACACACAGAGACACATACACATTGATCTTAAAATTTTTCTCAGTCACTGATATGCAAAGGACCACACTGTCTCTGCTTCCAGGAGTATTT
TAGAAATGTTCCACAATTTACTGAAGACATAGAGATGATGCTGCTGCTTAGGTGCCTTTTAGCAAGCTATGCAAACAATCCTGATAAAAC
AAGATACATAGAGAGTCAATCTGGCTTCTGAGAATTTACCAAGTGAACAGAGTACCTAGTTCATCAGCCGTCCAGTAAAGCAACCCAGGA
AACTGACTGGGTCTCTTTGCCTACCGTATTAACATTAAACATTGATGTTCTGTATTCTGTACTTTACTGCACCCAGCAGACTTTCAACAA
CTCATTGATCCAAAGATACATGCACAGTCTGAGCACCAGCTATGGTGCTCATAACTTCTTTAAGACTTGAACCCTTTCAATCTGTGTGAT
TCATTAAATTGGACCATTGATGATAAGAATACACATTGTATGTTTCTGTGCACATGACAGTGTGTGTGTGTGCACGTACATACTGTATAG
TCTTAAAAATAGCATTATACTGGCCAGGGGTGGTGGCTAACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCAACTGTG
GTCAGGAGTTTGAGATCAGCCAGGCCAACCTGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGATGGTGGGCGCCT
GTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCACCATTGCAC
TCCAGTCTGGGCAACAGAGTGAGATTCCGTCTCAAAAAAAAAAAGAAAAGGAAAAAAAAATAGCATTATACCTCTTCCTTGTCTCAACCG
CCATGAAAATTCTGAACACTCCAAATTCAGTTGAATAATCCAAAACAAAATTTATAAGTATAAAATAATTTTACTTCTTATAGTAATAGT
ATACTTTAAAAAGCCTCAGGGTATATTATCTTCTAAACAGCTACAATTCAGTGCAGCTACATTAACCAACTATGTTCTCTAGTTGAGAAC
AACTAGGCCTATTTCACTGCTGTGTAGCCTCAGTGCCTAACATGGGTGCCAAATAAATATTCGTAGAATTACACTGAATTGTAAAAACCA
TTCGTTTTTGTTTACAATTGCCAAAAATCTCAAAAGGCCCTGTATTTATGTAATTCTTTGAAATTATTATTTTATTTTGATTTCTCAGTT
ATTGACTGGCTGGGTGTGACTTAGTACATAAGTACTCAATATTATAAAAACCTCAAATAATTGACTTGATTTTACACAACATCCTTCCCT
TTTCTACAAGTTAATTTTTTTACAAATCATTTGGGTTATCTCCTAAATAGGTTATATTTTATTGCTTCTAGAAACAATGTTTCAAAATAT
ATGTGCATTATCAGTAATAATTTGTATAAATATTTCCCACAACAATTTTCATAATTTTCAAAGACTAATTTCTTGACTGAAGATATTTTG
CTAGGGAAGTGAAACTTTAAAATTTTGTAGATTTTAAAAAATATTGTTGAATGGTGTCATGCAAAGGATTTATATAGTGTGCTCCCACTA
ACTGTACAGATCAGGACACATATTTTTAGACATCTAAGTCTGTAGCTTAAATGGAGGTTACTCTTCCATCATCTAGAATTGTTTACTTAG
TAATTGTTGTTTCTTTTATTATTATAGACTTACTATCAGTTTTATTTTGCCAAGTATGCAACAGGTATATCACTAGTATATGAAAATGTA
AATATCACTTGTGTACTCAAACAAAAGTTGGTCTTAAGCTTCCACCTTGAGCAGCCTTGGAAACCTAACCTGCCTCTTTTAGCATAATCA
CATTTTCTAAATGATTTTCTTTGTTCCTGAAAAAGTGATTTGTATTAGTTTTACATTTGTTTTTTGGAAGATTATATTTGTATATGTATC
ATCATAAAATATTTAAATAAAAAGTATCTTTAGAGTGACCCTTTCCCCATAGATTTTTATTTCTCTATTATATTTTACAAGGAATATAAC
TCAGTTTGTTAGGGAGAGTGCCTTAAAGGCAGGTGTTTCTTGGACTTTGTTATTTAATTAGATCTGCTTGCAATAAAAAAAGTTGTCGGT

>62267_62267_1_PACS2-DSG2_PACS2_chr14_105818804_ENST00000325438_DSG2_chr18_29104666_ENST00000261590_length(amino acids)=1050AA_BP=224
MRRRRLDPRRRAGAPPSQSAAPARVGGRRARAGRPGARGARAGRRAGRGGAAAARRRPRACPTPGPGPSPPPPGSHVTAPPPSARPARPP
RVRGPAAAPGRRGSGGAGAMAERGRLGLPGAPGALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVKMQGS
KRILRSHEIVLPPSGQVETDLALTFSLQLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIK
EVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARY
VKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAE
DLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYV
GLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKG
SSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDE
NHTAKDCLLVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNS
ENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVY
APASTLVDQPYANEGTVVVTERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQ

--------------------------------------------------------------
>62267_62267_2_PACS2-DSG2_PACS2_chr14_105818804_ENST00000430725_DSG2_chr18_29104666_ENST00000261590_length(transcript)=5389nt_BP=595nt
CGTCCCCGCGCGCCGCGTCCAGCTCGATGTCCGTGCCGCCGCAACCGCGGCACACGCGGCCCGTCATGCCGGCGACCGCGCGGGCAGCGC
CCGGAGCCTCCCAAGACTCTCAAGCCACCCGAGCCTCCGGAGCAGCCCGCGCCGCCCGCCCAGGCCCAGCCGCCCAGGCCTCGCCGCTCT
CGCGAGGCCCCGCTCCAGCCGATTCGCAGCCGCAGATTCGCCGCGCGCGCCCGGGCCGCGCCGCCCGCAACGGCCGCGCCCGCGGGATGG
GACAGGCACCGGGACCACGGCGGGGACGCGAGGACTGGAGCCGCGACCTCCCCACTGCGAGCGAGCTGGCCTCCCTTGCGGCGCGCCGGC
GTCGGAGGGGCGACCTGCGGGGGCTGGGCTTCGGCGGAACCCGAGCGGGGCCTACCGGTTGTGCAGCCTGACTCTGAAGAAGCTGGTGGT
CTTCAAGGAGCTGGAGAAGGAGCTGATCTCCGTGGTGATCGCTGTCAAGATGCAGGGCTCCAAACGAATCCTGCGGTCCCATGAGATTGT
GCTGCCCCCCAGTGGACAAGTGGAGACAGACCTGGCCCTGACCTTCTCCTTGCAGCTTGAAGGGATGGTTGAAGAAAATCAAGTCAACGT
AGAAGTTACGCGCATAAAAGTGTTCGATGCAGATGAAATAGGTTCTGATAATTGGCTGGCAAATTTTACATTTGCATCAGGAAATGAAGG
AGGTTATTTCCACATAGAAACAGATGCTCAAACTAACGAAGGAATTGTGACCCTTATTAAGGAAGTAGATTATGAAGAAATGAAGAATCT
TGACTTCAGTGTTATTGTCGCTAATAAAGCAGCTTTTCACAAGTCGATTAGGAGTAAATACAAGCCTACACCCATTCCCATCAAGGTCAA
AGTGAAAAATGTGAAAGAAGGCATTCATTTTAAAAGCAGCGTCATCTCAATTTATGTTAGCGAGAGCATGGATAGATCAAGCAAAGGCCA
AATAATTGGAAATTTTCAAGCTTTTGATGAGGACACTGGACTACCAGCCCATGCAAGATATGTAAAATTAGAAGATAGAGATAATTGGAT
CTCTGTGGATTCTGTCACATCTGAAATTAAACTTGCAAAACTTCCTGATTTTGAATCTAGATATGTTCAAAATGGCACATACACTGTAAA
GATTGTGGCCATATCAGAAGATTATCCTAGAAAAACCATCACTGGCACAGTCCTTATCAATGTTGAAGACATCAACGACAACTGTCCCAC
ACTGATAGAGCCTGTGCAGACAATCTGTCACGATGCAGAGTATGTGAATGTTACTGCAGAGGACCTGGATGGACACCCAAACAGTGGCCC
TTTCAGTTTCTCCGTCATTGACAAACCACCTGGCATGGCAGAAAAATGGAAAATAGCACGCCAAGAAAGTACCAGTGTGCTGCTGCAACA
AAGTGAGAAAAAGCTTGGGAGAAGTGAAATTCAGTTCCTGATTTCAGACAATCAGGGTTTTAGTTGTCCTGAAAAGCAGGTCCTTACACT
CACAGTTTGTGAGTGTCTGCATGGCAGCGGCTGCAGGGAAGCACAGCATGACTCCTATGTGGGCCTGGGACCCGCAGCAATTGCGCTCAT
GATTTTGGCCTTTCTGCTCCTGCTATTGGTACCACTTTTACTGCTGATGTGCCATTGCGGAAAGGGCGCCAAAGGCTTTACCCCCATACC
TGGCACCATAGAGATGCTGCATCCTTGGAATAATGAAGGAGCACCACCTGAAGACAAGGTGGTGCCATCATTTCTGCCAGTGGATCAAGG
GGGCAGTCTAGTAGGAAGAAATGGAGTAGGAGGTATGGCCAAGGAAGCCACGATGAAAGGAAGTAGCTCTGCTTCCATTGTCAAAGGGCA
ACATGAGATGTCCGAGATGGATGGAAGGTGGGAAGAACACAGAAGCCTGCTTTCTGGTAGAGCTACCCAGTTTACAGGGGCCACAGGCGC
TATCATGACCACTGAAACCACGAAGACCGCAAGGGCCACAGGGGCTTCCAGAGACATGGCCGGAGCTCAGGCAGCTGCTGTTGCACTGAA
CGAAGAATTCTTAAGAAATTATTTCACTGATAAAGCGGCCTCTTACACTGAGGAAGATGAAAATCACACAGCCAAAGATTGCCTTCTGGT
TTATTCTCAGGAAGAAACTGAATCGCTGAATGCTTCTATTGGTTGTTGCAGTTTTATTGAAGGAGAGCTAGATGACCGCTTCTTAGATGA
TTTGGGACTTAAATTCAAGACACTAGCTGAAGTTTGCCTGGGTCAAAAAATAGATATAAATAAGGAAATTGAGCAGAGACAAAAACCTGC
CACAGAAACAAGTATGAACACAGCTTCACATTCACTCTGTGAGCAAACTATGGTTAATTCAGAGAATACCTACTCCTCTGGCAGTAGCTT
CCCAGTTCCAAAATCTTTGCAAGAAGCCAATGCAGAGAAAGTAACTCAGGAAATAGTCACTGAAAGATCTGTGTCTTCTAGGCAGGCGCA
AAAGGTAGCTACACCTCTTCCTGACCCAATGGCTTCTAGAAATGTGATAGCAACAGAAACTTCCTATGTCACAGGGTCCACTATGCCACC
AACCACTGTGATCCTGGGTCCTAGCCAGCCACAGAGCCTTATTGTGACAGAGAGGGTGTATGCTCCAGCTTCTACCTTGGTAGATCAGCC
TTATGCTAATGAAGGTACAGTTGTGGTCACTGAAAGAGTAATACAGCCTCATGGGGGTGGATCGAATCCTCTGGAAGGCACTCAGCATCT
TCAAGATGTACCTTACGTCATGGTGAGGGAAAGAGAGAGCTTCCTTGCCCCCAGCTCAGGTGTGCAGCCTACTCTGGCCATGCCTAATAT
AGCAGTAGGACAGAATGTGACAGTGACAGAAAGAGTTCTAGCACCTGCTTCCACTCTGCAATCCAGTTACCAGATTCCCACTGAAAATTC
TATGACGGCTAGGAACACCACGGTGTCTGGAGCTGGAGTCCCTGGCCCTCTGCCAGATTTTGGTTTAGAGGAATCTGGTCATTCTAATTC
TACCATAACCACATCTTCCACCAGAGTTACCAAGCATAGCACTGTACAGCATTCTTACTCCTAAACAGCAGTCAGCCACAAACTGACCCA
GAGTTTAATTAGCAGTGACTAATTTCATGTTTCCAATGTACCTGATTTTTCATGAGCCTTACAGACACACAGAGACACATACACATTGAT
CTTAAAATTTTTCTCAGTCACTGATATGCAAAGGACCACACTGTCTCTGCTTCCAGGAGTATTTTAGAAATGTTCCACAATTTACTGAAG
ACATAGAGATGATGCTGCTGCTTAGGTGCCTTTTAGCAAGCTATGCAAACAATCCTGATAAAACAAGATACATAGAGAGTCAATCTGGCT
TCTGAGAATTTACCAAGTGAACAGAGTACCTAGTTCATCAGCCGTCCAGTAAAGCAACCCAGGAAACTGACTGGGTCTCTTTGCCTACCG
TATTAACATTAAACATTGATGTTCTGTATTCTGTACTTTACTGCACCCAGCAGACTTTCAACAACTCATTGATCCAAAGATACATGCACA
GTCTGAGCACCAGCTATGGTGCTCATAACTTCTTTAAGACTTGAACCCTTTCAATCTGTGTGATTCATTAAATTGGACCATTGATGATAA
GAATACACATTGTATGTTTCTGTGCACATGACAGTGTGTGTGTGTGCACGTACATACTGTATAGTCTTAAAAATAGCATTATACTGGCCA
GGGGTGGTGGCTAACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCAACTGTGGTCAGGAGTTTGAGATCAGCCAGGCC
AACCTGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGATGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGA
GGCAGGAGAATCACTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAGTCTGGGCAACAGAGTGAGATT
CCGTCTCAAAAAAAAAAAGAAAAGGAAAAAAAAATAGCATTATACCTCTTCCTTGTCTCAACCGCCATGAAAATTCTGAACACTCCAAAT
TCAGTTGAATAATCCAAAACAAAATTTATAAGTATAAAATAATTTTACTTCTTATAGTAATAGTATACTTTAAAAAGCCTCAGGGTATAT
TATCTTCTAAACAGCTACAATTCAGTGCAGCTACATTAACCAACTATGTTCTCTAGTTGAGAACAACTAGGCCTATTTCACTGCTGTGTA
GCCTCAGTGCCTAACATGGGTGCCAAATAAATATTCGTAGAATTACACTGAATTGTAAAAACCATTCGTTTTTGTTTACAATTGCCAAAA
ATCTCAAAAGGCCCTGTATTTATGTAATTCTTTGAAATTATTATTTTATTTTGATTTCTCAGTTATTGACTGGCTGGGTGTGACTTAGTA
CATAAGTACTCAATATTATAAAAACCTCAAATAATTGACTTGATTTTACACAACATCCTTCCCTTTTCTACAAGTTAATTTTTTTACAAA
TCATTTGGGTTATCTCCTAAATAGGTTATATTTTATTGCTTCTAGAAACAATGTTTCAAAATATATGTGCATTATCAGTAATAATTTGTA
TAAATATTTCCCACAACAATTTTCATAATTTTCAAAGACTAATTTCTTGACTGAAGATATTTTGCTAGGGAAGTGAAACTTTAAAATTTT
GTAGATTTTAAAAAATATTGTTGAATGGTGTCATGCAAAGGATTTATATAGTGTGCTCCCACTAACTGTACAGATCAGGACACATATTTT
TAGACATCTAAGTCTGTAGCTTAAATGGAGGTTACTCTTCCATCATCTAGAATTGTTTACTTAGTAATTGTTGTTTCTTTTATTATTATA
GACTTACTATCAGTTTTATTTTGCCAAGTATGCAACAGGTATATCACTAGTATATGAAAATGTAAATATCACTTGTGTACTCAAACAAAA
GTTGGTCTTAAGCTTCCACCTTGAGCAGCCTTGGAAACCTAACCTGCCTCTTTTAGCATAATCACATTTTCTAAATGATTTTCTTTGTTC
CTGAAAAAGTGATTTGTATTAGTTTTACATTTGTTTTTTGGAAGATTATATTTGTATATGTATCATCATAAAATATTTAAATAAAAAGTA
TCTTTAGAGTGACCCTTTCCCCATAGATTTTTATTTCTCTATTATATTTTACAAGGAATATAACTCAGTTTGTTAGGGAGAGTGCCTTAA

>62267_62267_2_PACS2-DSG2_PACS2_chr14_105818804_ENST00000430725_DSG2_chr18_29104666_ENST00000261590_length(amino acids)=939AA_BP=113
MEPRPPHCERAGLPCGAPASEGRPAGAGLRRNPSGAYRLCSLTLKKLVVFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVETDL
ALTFSLQLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAA
FHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKL
AKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPG
MAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVP
LLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWE
EHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNA
SIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANA
EKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVVTE
RVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGA

--------------------------------------------------------------
>62267_62267_3_PACS2-DSG2_PACS2_chr14_105818804_ENST00000447393_DSG2_chr18_29104666_ENST00000261590_length(transcript)=5266nt_BP=472nt
GGCCGCAGCTCGTCGCCGCCCGCGGGCCTGTCCGACGCCGGGGCCCGGCCCGTCCCCTCCGCCGCCCGGCAGCCATGTGACCGCGCCGCC
GCCCTCCGCGCGCCCGGCCCGCCCGCCGCGCGTCCGCGGCCCGGCCGCAGCCCCAGGCCGCCGAGGGAGCGGCGGGGCCGGCGCCATGGC
CGAGCGAGGCCGCCTCGGCCTCCCCGGCGCGCCCGGCGCGCTCAACACGCCCGTGCCCATGAACCTGTTCGCCACCTGGGAGGTGGACGG
CTCCAGCCCCAGCTGCGTGCCCAGGTTGTGCAGCCTGACTCTGAAGAAGCTGGTGGTCTTCAAGGAGCTGGAGAAGGAGCTGATCTCCGT
GGTGATCGCTGTCAAGATGCAGGGCTCCAAACGAATCCTGCGGTCCCATGAGATTGTGCTGCCCCCCAGTGGACAAGTGGAGACAGACCT
GGCCCTGACCTTCTCCTTGCAGCTTGAAGGGATGGTTGAAGAAAATCAAGTCAACGTAGAAGTTACGCGCATAAAAGTGTTCGATGCAGA
TGAAATAGGTTCTGATAATTGGCTGGCAAATTTTACATTTGCATCAGGAAATGAAGGAGGTTATTTCCACATAGAAACAGATGCTCAAAC
TAACGAAGGAATTGTGACCCTTATTAAGGAAGTAGATTATGAAGAAATGAAGAATCTTGACTTCAGTGTTATTGTCGCTAATAAAGCAGC
TTTTCACAAGTCGATTAGGAGTAAATACAAGCCTACACCCATTCCCATCAAGGTCAAAGTGAAAAATGTGAAAGAAGGCATTCATTTTAA
AAGCAGCGTCATCTCAATTTATGTTAGCGAGAGCATGGATAGATCAAGCAAAGGCCAAATAATTGGAAATTTTCAAGCTTTTGATGAGGA
CACTGGACTACCAGCCCATGCAAGATATGTAAAATTAGAAGATAGAGATAATTGGATCTCTGTGGATTCTGTCACATCTGAAATTAAACT
TGCAAAACTTCCTGATTTTGAATCTAGATATGTTCAAAATGGCACATACACTGTAAAGATTGTGGCCATATCAGAAGATTATCCTAGAAA
AACCATCACTGGCACAGTCCTTATCAATGTTGAAGACATCAACGACAACTGTCCCACACTGATAGAGCCTGTGCAGACAATCTGTCACGA
TGCAGAGTATGTGAATGTTACTGCAGAGGACCTGGATGGACACCCAAACAGTGGCCCTTTCAGTTTCTCCGTCATTGACAAACCACCTGG
CATGGCAGAAAAATGGAAAATAGCACGCCAAGAAAGTACCAGTGTGCTGCTGCAACAAAGTGAGAAAAAGCTTGGGAGAAGTGAAATTCA
GTTCCTGATTTCAGACAATCAGGGTTTTAGTTGTCCTGAAAAGCAGGTCCTTACACTCACAGTTTGTGAGTGTCTGCATGGCAGCGGCTG
CAGGGAAGCACAGCATGACTCCTATGTGGGCCTGGGACCCGCAGCAATTGCGCTCATGATTTTGGCCTTTCTGCTCCTGCTATTGGTACC
ACTTTTACTGCTGATGTGCCATTGCGGAAAGGGCGCCAAAGGCTTTACCCCCATACCTGGCACCATAGAGATGCTGCATCCTTGGAATAA
TGAAGGAGCACCACCTGAAGACAAGGTGGTGCCATCATTTCTGCCAGTGGATCAAGGGGGCAGTCTAGTAGGAAGAAATGGAGTAGGAGG
TATGGCCAAGGAAGCCACGATGAAAGGAAGTAGCTCTGCTTCCATTGTCAAAGGGCAACATGAGATGTCCGAGATGGATGGAAGGTGGGA
AGAACACAGAAGCCTGCTTTCTGGTAGAGCTACCCAGTTTACAGGGGCCACAGGCGCTATCATGACCACTGAAACCACGAAGACCGCAAG
GGCCACAGGGGCTTCCAGAGACATGGCCGGAGCTCAGGCAGCTGCTGTTGCACTGAACGAAGAATTCTTAAGAAATTATTTCACTGATAA
AGCGGCCTCTTACACTGAGGAAGATGAAAATCACACAGCCAAAGATTGCCTTCTGGTTTATTCTCAGGAAGAAACTGAATCGCTGAATGC
TTCTATTGGTTGTTGCAGTTTTATTGAAGGAGAGCTAGATGACCGCTTCTTAGATGATTTGGGACTTAAATTCAAGACACTAGCTGAAGT
TTGCCTGGGTCAAAAAATAGATATAAATAAGGAAATTGAGCAGAGACAAAAACCTGCCACAGAAACAAGTATGAACACAGCTTCACATTC
ACTCTGTGAGCAAACTATGGTTAATTCAGAGAATACCTACTCCTCTGGCAGTAGCTTCCCAGTTCCAAAATCTTTGCAAGAAGCCAATGC
AGAGAAAGTAACTCAGGAAATAGTCACTGAAAGATCTGTGTCTTCTAGGCAGGCGCAAAAGGTAGCTACACCTCTTCCTGACCCAATGGC
TTCTAGAAATGTGATAGCAACAGAAACTTCCTATGTCACAGGGTCCACTATGCCACCAACCACTGTGATCCTGGGTCCTAGCCAGCCACA
GAGCCTTATTGTGACAGAGAGGGTGTATGCTCCAGCTTCTACCTTGGTAGATCAGCCTTATGCTAATGAAGGTACAGTTGTGGTCACTGA
AAGAGTAATACAGCCTCATGGGGGTGGATCGAATCCTCTGGAAGGCACTCAGCATCTTCAAGATGTACCTTACGTCATGGTGAGGGAAAG
AGAGAGCTTCCTTGCCCCCAGCTCAGGTGTGCAGCCTACTCTGGCCATGCCTAATATAGCAGTAGGACAGAATGTGACAGTGACAGAAAG
AGTTCTAGCACCTGCTTCCACTCTGCAATCCAGTTACCAGATTCCCACTGAAAATTCTATGACGGCTAGGAACACCACGGTGTCTGGAGC
TGGAGTCCCTGGCCCTCTGCCAGATTTTGGTTTAGAGGAATCTGGTCATTCTAATTCTACCATAACCACATCTTCCACCAGAGTTACCAA
GCATAGCACTGTACAGCATTCTTACTCCTAAACAGCAGTCAGCCACAAACTGACCCAGAGTTTAATTAGCAGTGACTAATTTCATGTTTC
CAATGTACCTGATTTTTCATGAGCCTTACAGACACACAGAGACACATACACATTGATCTTAAAATTTTTCTCAGTCACTGATATGCAAAG
GACCACACTGTCTCTGCTTCCAGGAGTATTTTAGAAATGTTCCACAATTTACTGAAGACATAGAGATGATGCTGCTGCTTAGGTGCCTTT
TAGCAAGCTATGCAAACAATCCTGATAAAACAAGATACATAGAGAGTCAATCTGGCTTCTGAGAATTTACCAAGTGAACAGAGTACCTAG
TTCATCAGCCGTCCAGTAAAGCAACCCAGGAAACTGACTGGGTCTCTTTGCCTACCGTATTAACATTAAACATTGATGTTCTGTATTCTG
TACTTTACTGCACCCAGCAGACTTTCAACAACTCATTGATCCAAAGATACATGCACAGTCTGAGCACCAGCTATGGTGCTCATAACTTCT
TTAAGACTTGAACCCTTTCAATCTGTGTGATTCATTAAATTGGACCATTGATGATAAGAATACACATTGTATGTTTCTGTGCACATGACA
GTGTGTGTGTGTGCACGTACATACTGTATAGTCTTAAAAATAGCATTATACTGGCCAGGGGTGGTGGCTAACGCCTGTAATCCCAGCACT
TTGGGAGGCCGAGGCGGGTGGATCAACTGTGGTCAGGAGTTTGAGATCAGCCAGGCCAACCTGGTGAAACCCCGTCTCTACTAAAAATAC
AAAAATTAGCTGGGCGTGATGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCGGAG
GTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAGTCTGGGCAACAGAGTGAGATTCCGTCTCAAAAAAAAAAAGAAAAGGAAAAAAAA
ATAGCATTATACCTCTTCCTTGTCTCAACCGCCATGAAAATTCTGAACACTCCAAATTCAGTTGAATAATCCAAAACAAAATTTATAAGT
ATAAAATAATTTTACTTCTTATAGTAATAGTATACTTTAAAAAGCCTCAGGGTATATTATCTTCTAAACAGCTACAATTCAGTGCAGCTA
CATTAACCAACTATGTTCTCTAGTTGAGAACAACTAGGCCTATTTCACTGCTGTGTAGCCTCAGTGCCTAACATGGGTGCCAAATAAATA
TTCGTAGAATTACACTGAATTGTAAAAACCATTCGTTTTTGTTTACAATTGCCAAAAATCTCAAAAGGCCCTGTATTTATGTAATTCTTT
GAAATTATTATTTTATTTTGATTTCTCAGTTATTGACTGGCTGGGTGTGACTTAGTACATAAGTACTCAATATTATAAAAACCTCAAATA
ATTGACTTGATTTTACACAACATCCTTCCCTTTTCTACAAGTTAATTTTTTTACAAATCATTTGGGTTATCTCCTAAATAGGTTATATTT
TATTGCTTCTAGAAACAATGTTTCAAAATATATGTGCATTATCAGTAATAATTTGTATAAATATTTCCCACAACAATTTTCATAATTTTC
AAAGACTAATTTCTTGACTGAAGATATTTTGCTAGGGAAGTGAAACTTTAAAATTTTGTAGATTTTAAAAAATATTGTTGAATGGTGTCA
TGCAAAGGATTTATATAGTGTGCTCCCACTAACTGTACAGATCAGGACACATATTTTTAGACATCTAAGTCTGTAGCTTAAATGGAGGTT
ACTCTTCCATCATCTAGAATTGTTTACTTAGTAATTGTTGTTTCTTTTATTATTATAGACTTACTATCAGTTTTATTTTGCCAAGTATGC
AACAGGTATATCACTAGTATATGAAAATGTAAATATCACTTGTGTACTCAAACAAAAGTTGGTCTTAAGCTTCCACCTTGAGCAGCCTTG
GAAACCTAACCTGCCTCTTTTAGCATAATCACATTTTCTAAATGATTTTCTTTGTTCCTGAAAAAGTGATTTGTATTAGTTTTACATTTG
TTTTTTGGAAGATTATATTTGTATATGTATCATCATAAAATATTTAAATAAAAAGTATCTTTAGAGTGACCCTTTCCCCATAGATTTTTA
TTTCTCTATTATATTTTACAAGGAATATAACTCAGTTTGTTAGGGAGAGTGCCTTAAAGGCAGGTGTTTCTTGGACTTTGTTATTTAATT

>62267_62267_3_PACS2-DSG2_PACS2_chr14_105818804_ENST00000447393_DSG2_chr18_29104666_ENST00000261590_length(amino acids)=941AA_BP=115
MAERGRLGLPGAPGALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVET
DLALTFSLQLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANK
AAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEI
KLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKP
PGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLL
VPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGR
WEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESL
NASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEA
NAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVV
TERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVS

--------------------------------------------------------------
>62267_62267_4_PACS2-DSG2_PACS2_chr14_105818804_ENST00000458164_DSG2_chr18_29104666_ENST00000261590_length(transcript)=5266nt_BP=472nt
GGCCGCAGCTCGTCGCCGCCCGCGGGCCTGTCCGACGCCGGGGCCCGGCCCGTCCCCTCCGCCGCCCGGCAGCCATGTGACCGCGCCGCC
GCCCTCCGCGCGCCCGGCCCGCCCGCCGCGCGTCCGCGGCCCGGCCGCAGCCCCAGGCCGCCGAGGGAGCGGCGGGGCCGGCGCCATGGC
CGAGCGAGGCCGCCTCGGCCTCCCCGGCGCGCCCGGCGCGCTCAACACGCCCGTGCCCATGAACCTGTTCGCCACCTGGGAGGTGGACGG
CTCCAGCCCCAGCTGCGTGCCCAGGTTGTGCAGCCTGACTCTGAAGAAGCTGGTGGTCTTCAAGGAGCTGGAGAAGGAGCTGATCTCCGT
GGTGATCGCTGTCAAGATGCAGGGCTCCAAACGAATCCTGCGGTCCCATGAGATTGTGCTGCCCCCCAGTGGACAAGTGGAGACAGACCT
GGCCCTGACCTTCTCCTTGCAGCTTGAAGGGATGGTTGAAGAAAATCAAGTCAACGTAGAAGTTACGCGCATAAAAGTGTTCGATGCAGA
TGAAATAGGTTCTGATAATTGGCTGGCAAATTTTACATTTGCATCAGGAAATGAAGGAGGTTATTTCCACATAGAAACAGATGCTCAAAC
TAACGAAGGAATTGTGACCCTTATTAAGGAAGTAGATTATGAAGAAATGAAGAATCTTGACTTCAGTGTTATTGTCGCTAATAAAGCAGC
TTTTCACAAGTCGATTAGGAGTAAATACAAGCCTACACCCATTCCCATCAAGGTCAAAGTGAAAAATGTGAAAGAAGGCATTCATTTTAA
AAGCAGCGTCATCTCAATTTATGTTAGCGAGAGCATGGATAGATCAAGCAAAGGCCAAATAATTGGAAATTTTCAAGCTTTTGATGAGGA
CACTGGACTACCAGCCCATGCAAGATATGTAAAATTAGAAGATAGAGATAATTGGATCTCTGTGGATTCTGTCACATCTGAAATTAAACT
TGCAAAACTTCCTGATTTTGAATCTAGATATGTTCAAAATGGCACATACACTGTAAAGATTGTGGCCATATCAGAAGATTATCCTAGAAA
AACCATCACTGGCACAGTCCTTATCAATGTTGAAGACATCAACGACAACTGTCCCACACTGATAGAGCCTGTGCAGACAATCTGTCACGA
TGCAGAGTATGTGAATGTTACTGCAGAGGACCTGGATGGACACCCAAACAGTGGCCCTTTCAGTTTCTCCGTCATTGACAAACCACCTGG
CATGGCAGAAAAATGGAAAATAGCACGCCAAGAAAGTACCAGTGTGCTGCTGCAACAAAGTGAGAAAAAGCTTGGGAGAAGTGAAATTCA
GTTCCTGATTTCAGACAATCAGGGTTTTAGTTGTCCTGAAAAGCAGGTCCTTACACTCACAGTTTGTGAGTGTCTGCATGGCAGCGGCTG
CAGGGAAGCACAGCATGACTCCTATGTGGGCCTGGGACCCGCAGCAATTGCGCTCATGATTTTGGCCTTTCTGCTCCTGCTATTGGTACC
ACTTTTACTGCTGATGTGCCATTGCGGAAAGGGCGCCAAAGGCTTTACCCCCATACCTGGCACCATAGAGATGCTGCATCCTTGGAATAA
TGAAGGAGCACCACCTGAAGACAAGGTGGTGCCATCATTTCTGCCAGTGGATCAAGGGGGCAGTCTAGTAGGAAGAAATGGAGTAGGAGG
TATGGCCAAGGAAGCCACGATGAAAGGAAGTAGCTCTGCTTCCATTGTCAAAGGGCAACATGAGATGTCCGAGATGGATGGAAGGTGGGA
AGAACACAGAAGCCTGCTTTCTGGTAGAGCTACCCAGTTTACAGGGGCCACAGGCGCTATCATGACCACTGAAACCACGAAGACCGCAAG
GGCCACAGGGGCTTCCAGAGACATGGCCGGAGCTCAGGCAGCTGCTGTTGCACTGAACGAAGAATTCTTAAGAAATTATTTCACTGATAA
AGCGGCCTCTTACACTGAGGAAGATGAAAATCACACAGCCAAAGATTGCCTTCTGGTTTATTCTCAGGAAGAAACTGAATCGCTGAATGC
TTCTATTGGTTGTTGCAGTTTTATTGAAGGAGAGCTAGATGACCGCTTCTTAGATGATTTGGGACTTAAATTCAAGACACTAGCTGAAGT
TTGCCTGGGTCAAAAAATAGATATAAATAAGGAAATTGAGCAGAGACAAAAACCTGCCACAGAAACAAGTATGAACACAGCTTCACATTC
ACTCTGTGAGCAAACTATGGTTAATTCAGAGAATACCTACTCCTCTGGCAGTAGCTTCCCAGTTCCAAAATCTTTGCAAGAAGCCAATGC
AGAGAAAGTAACTCAGGAAATAGTCACTGAAAGATCTGTGTCTTCTAGGCAGGCGCAAAAGGTAGCTACACCTCTTCCTGACCCAATGGC
TTCTAGAAATGTGATAGCAACAGAAACTTCCTATGTCACAGGGTCCACTATGCCACCAACCACTGTGATCCTGGGTCCTAGCCAGCCACA
GAGCCTTATTGTGACAGAGAGGGTGTATGCTCCAGCTTCTACCTTGGTAGATCAGCCTTATGCTAATGAAGGTACAGTTGTGGTCACTGA
AAGAGTAATACAGCCTCATGGGGGTGGATCGAATCCTCTGGAAGGCACTCAGCATCTTCAAGATGTACCTTACGTCATGGTGAGGGAAAG
AGAGAGCTTCCTTGCCCCCAGCTCAGGTGTGCAGCCTACTCTGGCCATGCCTAATATAGCAGTAGGACAGAATGTGACAGTGACAGAAAG
AGTTCTAGCACCTGCTTCCACTCTGCAATCCAGTTACCAGATTCCCACTGAAAATTCTATGACGGCTAGGAACACCACGGTGTCTGGAGC
TGGAGTCCCTGGCCCTCTGCCAGATTTTGGTTTAGAGGAATCTGGTCATTCTAATTCTACCATAACCACATCTTCCACCAGAGTTACCAA
GCATAGCACTGTACAGCATTCTTACTCCTAAACAGCAGTCAGCCACAAACTGACCCAGAGTTTAATTAGCAGTGACTAATTTCATGTTTC
CAATGTACCTGATTTTTCATGAGCCTTACAGACACACAGAGACACATACACATTGATCTTAAAATTTTTCTCAGTCACTGATATGCAAAG
GACCACACTGTCTCTGCTTCCAGGAGTATTTTAGAAATGTTCCACAATTTACTGAAGACATAGAGATGATGCTGCTGCTTAGGTGCCTTT
TAGCAAGCTATGCAAACAATCCTGATAAAACAAGATACATAGAGAGTCAATCTGGCTTCTGAGAATTTACCAAGTGAACAGAGTACCTAG
TTCATCAGCCGTCCAGTAAAGCAACCCAGGAAACTGACTGGGTCTCTTTGCCTACCGTATTAACATTAAACATTGATGTTCTGTATTCTG
TACTTTACTGCACCCAGCAGACTTTCAACAACTCATTGATCCAAAGATACATGCACAGTCTGAGCACCAGCTATGGTGCTCATAACTTCT
TTAAGACTTGAACCCTTTCAATCTGTGTGATTCATTAAATTGGACCATTGATGATAAGAATACACATTGTATGTTTCTGTGCACATGACA
GTGTGTGTGTGTGCACGTACATACTGTATAGTCTTAAAAATAGCATTATACTGGCCAGGGGTGGTGGCTAACGCCTGTAATCCCAGCACT
TTGGGAGGCCGAGGCGGGTGGATCAACTGTGGTCAGGAGTTTGAGATCAGCCAGGCCAACCTGGTGAAACCCCGTCTCTACTAAAAATAC
AAAAATTAGCTGGGCGTGATGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCGGAG
GTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAGTCTGGGCAACAGAGTGAGATTCCGTCTCAAAAAAAAAAAGAAAAGGAAAAAAAA
ATAGCATTATACCTCTTCCTTGTCTCAACCGCCATGAAAATTCTGAACACTCCAAATTCAGTTGAATAATCCAAAACAAAATTTATAAGT
ATAAAATAATTTTACTTCTTATAGTAATAGTATACTTTAAAAAGCCTCAGGGTATATTATCTTCTAAACAGCTACAATTCAGTGCAGCTA
CATTAACCAACTATGTTCTCTAGTTGAGAACAACTAGGCCTATTTCACTGCTGTGTAGCCTCAGTGCCTAACATGGGTGCCAAATAAATA
TTCGTAGAATTACACTGAATTGTAAAAACCATTCGTTTTTGTTTACAATTGCCAAAAATCTCAAAAGGCCCTGTATTTATGTAATTCTTT
GAAATTATTATTTTATTTTGATTTCTCAGTTATTGACTGGCTGGGTGTGACTTAGTACATAAGTACTCAATATTATAAAAACCTCAAATA
ATTGACTTGATTTTACACAACATCCTTCCCTTTTCTACAAGTTAATTTTTTTACAAATCATTTGGGTTATCTCCTAAATAGGTTATATTT
TATTGCTTCTAGAAACAATGTTTCAAAATATATGTGCATTATCAGTAATAATTTGTATAAATATTTCCCACAACAATTTTCATAATTTTC
AAAGACTAATTTCTTGACTGAAGATATTTTGCTAGGGAAGTGAAACTTTAAAATTTTGTAGATTTTAAAAAATATTGTTGAATGGTGTCA
TGCAAAGGATTTATATAGTGTGCTCCCACTAACTGTACAGATCAGGACACATATTTTTAGACATCTAAGTCTGTAGCTTAAATGGAGGTT
ACTCTTCCATCATCTAGAATTGTTTACTTAGTAATTGTTGTTTCTTTTATTATTATAGACTTACTATCAGTTTTATTTTGCCAAGTATGC
AACAGGTATATCACTAGTATATGAAAATGTAAATATCACTTGTGTACTCAAACAAAAGTTGGTCTTAAGCTTCCACCTTGAGCAGCCTTG
GAAACCTAACCTGCCTCTTTTAGCATAATCACATTTTCTAAATGATTTTCTTTGTTCCTGAAAAAGTGATTTGTATTAGTTTTACATTTG
TTTTTTGGAAGATTATATTTGTATATGTATCATCATAAAATATTTAAATAAAAAGTATCTTTAGAGTGACCCTTTCCCCATAGATTTTTA
TTTCTCTATTATATTTTACAAGGAATATAACTCAGTTTGTTAGGGAGAGTGCCTTAAAGGCAGGTGTTTCTTGGACTTTGTTATTTAATT

>62267_62267_4_PACS2-DSG2_PACS2_chr14_105818804_ENST00000458164_DSG2_chr18_29104666_ENST00000261590_length(amino acids)=941AA_BP=115
MAERGRLGLPGAPGALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVET
DLALTFSLQLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANK
AAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEI
KLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKP
PGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLL
VPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGR
WEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESL
NASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEA
NAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVV
TERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVS

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Top

Fusion Gene PPI Analysis for PACS2-DSG2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PACS2-DSG2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PACS2-DSG2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source