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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PACSIN2-NUPL2 (FusionGDB2 ID:62290)

Fusion Gene Summary for PACSIN2-NUPL2

Fusion gene summary

Fusion gene information	Fusion gene name: PACSIN2-NUPL2
	Fusion gene ID: 62290
		Hgene	Tgene
	Gene symbol	PACSIN2	NUPL2
	Gene ID	11252	11097
	Gene name	protein kinase C and casein kinase substrate in neurons 2	nucleoporin 42
	Synonyms	SDPII	CG1\|NLP-1\|NLP_1\|NUPL2\|hCG1
	Cytomap	22q13.2	7p15.3
	Type of gene	protein-coding	protein-coding
	Description	protein kinase C and casein kinase substrate in neurons protein 2cytoplasmic phosphoprotein PACSIN2syndapin-2syndapin-IIsyndapin2	nucleoporin NUP42H_RG271G13.9NUP42 homolognucleoporin hCG1nucleoporin like 2nucleoporin-like protein 1nucleoporin-like protein 2
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000263246, ENST00000337959, ENST00000402229, ENST00000403744, ENST00000407585,	ENST00000487595, ENST00000258742, ENST00000410002,
Fusion gene scores	* DoF score	22 X 13 X 11=3146	3 X 2 X 2=12
	# samples	32	3
	** MAII score	log2(32/3146*10)=-3.29737486052832 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: PACSIN2 [Title/Abstract] AND NUPL2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PACSIN2(43308027)-NUPL2(23224689), # samples:3
Anticipated loss of major functional domain due to fusion event.	PACSIN2-NUPL2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PACSIN2-NUPL2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PACSIN2	GO:0097320	plasma membrane tubulation	23596323

Fusion gene breakpoints across PACSIN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NUPL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AN-A0FJ-01A	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+

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Fusion Gene ORF analysis for PACSIN2-NUPL2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000263246	ENST00000487595	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+
5CDS-3UTR	ENST00000337959	ENST00000487595	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+
5CDS-3UTR	ENST00000402229	ENST00000487595	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+
5CDS-3UTR	ENST00000403744	ENST00000487595	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+
5CDS-3UTR	ENST00000407585	ENST00000487595	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+
Frame-shift	ENST00000402229	ENST00000258742	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+
Frame-shift	ENST00000402229	ENST00000410002	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+
Frame-shift	ENST00000407585	ENST00000258742	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+
Frame-shift	ENST00000407585	ENST00000410002	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+
In-frame	ENST00000263246	ENST00000258742	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+
In-frame	ENST00000263246	ENST00000410002	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+
In-frame	ENST00000337959	ENST00000258742	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+
In-frame	ENST00000337959	ENST00000410002	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+
In-frame	ENST00000403744	ENST00000258742	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+
In-frame	ENST00000403744	ENST00000410002	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000337959	PACSIN2	chr22	43308027	-	ENST00000258742	NUPL2	chr7	23224689	+	1677	262	255	1412	385
ENST00000337959	PACSIN2	chr22	43308027	-	ENST00000410002	NUPL2	chr7	23224689	+	773	262	255	608	117
ENST00000263246	PACSIN2	chr22	43308027	-	ENST00000258742	NUPL2	chr7	23224689	+	1677	262	255	1412	385
ENST00000263246	PACSIN2	chr22	43308027	-	ENST00000410002	NUPL2	chr7	23224689	+	773	262	255	608	117
ENST00000403744	PACSIN2	chr22	43308027	-	ENST00000258742	NUPL2	chr7	23224689	+	1697	282	275	1432	385
ENST00000403744	PACSIN2	chr22	43308027	-	ENST00000410002	NUPL2	chr7	23224689	+	793	282	275	628	117

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000337959	ENST00000258742	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+	0.007828664	0.9921713
ENST00000337959	ENST00000410002	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+	0.16165052	0.83834946
ENST00000263246	ENST00000258742	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+	0.007828664	0.9921713
ENST00000263246	ENST00000410002	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+	0.16165052	0.83834946
ENST00000403744	ENST00000258742	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+	0.008487879	0.9915121
ENST00000403744	ENST00000410002	PACSIN2	chr22	43308027	-	NUPL2	chr7	23224689	+	0.11801216	0.88198787

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Fusion Genomic Features for PACSIN2-NUPL2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PACSIN2	chr22	43308026	-	NUPL2	chr7	23224688	+	1.57E-05	0.9999844
PACSIN2	chr22	43308026	-	NUPL2	chr7	23224688	+	1.57E-05	0.9999844

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PACSIN2-NUPL2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:43308027/chr7:23224689)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NUPL2

chr22:43308027

chr7:23224689

ENST00000258742

238_378

424.0

Compositional bias

Note=Ser-rich

Tgene

NUPL2

chr22:43308027

chr7:23224689

ENST00000258742

218_219

424.0

Repeat

Note=FG 3

Tgene

NUPL2

chr22:43308027

chr7:23224689

ENST00000258742

220_221

424.0

Repeat

Note=FG 4

Tgene

NUPL2

chr22:43308027

chr7:23224689

ENST00000258742

265_266

424.0

Repeat

Note=FG 5

Tgene

NUPL2

chr22:43308027

chr7:23224689

ENST00000258742

271_272

424.0

Repeat

Note=FG 6

Tgene

NUPL2

chr22:43308027

chr7:23224689

ENST00000258742

288_289

424.0

Repeat

Note=FG 7

Tgene

NUPL2

chr22:43308027

chr7:23224689

ENST00000258742

290_291

424.0

Repeat

Note=FG 8

Tgene

NUPL2

chr22:43308027

chr7:23224689

ENST00000258742

311_312

424.0

Repeat

Note=FG 9

Tgene

NUPL2

chr22:43308027

chr7:23224689

ENST00000258742

336_337

424.0

Repeat

Note=FG 10

Tgene

NUPL2

chr22:43308027

chr7:23224689

ENST00000258742

345_346

424.0

Repeat

Note=FG 11

Tgene

NUPL2

chr22:43308027

chr7:23224689

ENST00000258742

364_365

424.0

Repeat

Note=FG 12

Tgene

NUPL2

chr22:43308027

chr7:23224689

ENST00000258742

95_96

424.0

Repeat

Note=FG 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000263246

25_274

487.0

Coiled coil

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000337959

25_274

446.0

Coiled coil

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000402229

25_274

487.0

Coiled coil

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000403744

25_274

487.0

Coiled coil

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000407585

25_274

446.0

Coiled coil

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000263246

11_282

487.0

Domain

F-BAR

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000263246

426_486

487.0

Domain

SH3

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000337959

11_282

446.0

Domain

F-BAR

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000337959

426_486

446.0

Domain

SH3

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000402229

11_282

487.0

Domain

F-BAR

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000402229

426_486

487.0

Domain

SH3

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000403744

11_282

487.0

Domain

F-BAR

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000403744

426_486

487.0

Domain

SH3

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000407585

11_282

446.0

Domain

F-BAR

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000407585

426_486

446.0

Domain

SH3

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000263246

362_364

487.0

Motif

Note=NPF1

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000263246

405_407

487.0

Motif

Note=NPF2

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000263246

417_419

487.0

Motif

Note=NPF3

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000337959

362_364

446.0

Motif

Note=NPF1

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000337959

405_407

446.0

Motif

Note=NPF2

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000337959

417_419

446.0

Motif

Note=NPF3

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000402229

362_364

487.0

Motif

Note=NPF1

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000402229

405_407

487.0

Motif

Note=NPF2

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000402229

417_419

487.0

Motif

Note=NPF3

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000403744

362_364

487.0

Motif

Note=NPF1

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000403744

405_407

487.0

Motif

Note=NPF2

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000403744

417_419

487.0

Motif

Note=NPF3

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000407585

362_364

446.0

Motif

Note=NPF1

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000407585

405_407

446.0

Motif

Note=NPF2

Hgene

PACSIN2

chr22:43308027

chr7:23224689

ENST00000407585

417_419

446.0

Motif

Note=NPF3

Tgene

NUPL2

chr22:43308027

chr7:23224689

ENST00000258742

14_15

424.0

Repeat

Note=FG 1

Tgene

NUPL2

chr22:43308027

chr7:23224689

ENST00000258742

1_25

424.0

Zinc finger

C3H1-type

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Fusion Gene Sequence for PACSIN2-NUPL2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>62290_62290_1_PACSIN2-NUPL2_PACSIN2_chr22_43308027_ENST00000263246_NUPL2_chr7_23224689_ENST00000258742_length(transcript)=1677nt_BP=262nt
GCGGCCGCAGGGGTCTGGGCAGGGCTGGGCAGTGCTGCCGGAGCAAAAGCGGTAGCGGGAGCCCGGCCGGAGCTGGGTCTGGAGACGCCG
TGGCAGCCTGAACGGAGTGTGCGACGGATTGGGAGGTTTGTCTACAGATTTTGAGCGTTCGAAGTTGACCCCTGACTAAGTATACTTTGC
TGCTCCCTCAGCCTTTGAAAAAATGTCTGTCACATATGATGATTCCGTTGGAGTAGAAGTGTCCAGCGACAGCTTCTGGGAGGTAATAAT
AGACGTGGATGGAATACAACTAGCCAGAGATATTCCAATGTCATCCAGCCATCCAGTTTCTCCAAATCCACACCATGGGGGGGCAGCAGA
GATCAAGAAAAGCCATATTTCAGTTCTTTTGATTCTGGAGCTTCAACTAACAGGAAGGAAGGCTTTGGATTGTCTGAGAACCCATTTGCT
TCACTTAGTCCTGATGAGCAGAAAGATGAAAAGAAACTTCTGGAAGGAATTGTAAAAGATATGGAGGTTTGGGAATCATCAGGGCAGTGG
ATGTTTTCTGTTTATTCACCAGTGAAAAAGAAACCTAATATTTCAGGTTTTACAGACATTTCACCAGAGGAATTGAGGCTTGAATACCAT
AACTTCTTAACCAGCAATAACTTACAGAGTTATCTAAATTCTGTCCAACGTTTAATAAATCAATGGAGGAACAGGGTAAATGAACTGAAA
AGTCTAAATATATCAACTAAAGTAGCTTTGCTCTCTGATGTAAAGGATGGAGTAAATCAAGCAGCACCTGCATTTGGATTTGGCAGCAGT
CAAGCAGCAACATTTATGTCGCCAGGCTTTCCAGTCAATAACAGCAGCAGTGATAATGCTCAGAACTTTAGTTTTAAAACAAACTCTGGA
TTTGCTGCTGCCTCTTCTGGAAGCCCTGCTGGTTTTGGGAGTTCCCCAGCATTTGGAGCTGCAGCCTCTACCAGTTCAGGTATCTCTACT
TCTGCTCCAGCTTTTGGATTTGGGAAGCCTGAAGTCACATCGGCTGCATCATTTTCATTCAAAAGCCCTGCAGCTTCCAGTTTTGGATCA
CCTGGATTTTCAGGACTTCCAGCTTCCTTGGCAACAGGTCCTGTCAGAGCTCCAGTGGCCCCAGCCTTTGGAGGTGGCAGTTCTGTGGCT
GGTTTTGGTAGTCCGGGCTCACATTCTCACACTGCTTTTTCTAAGCCATCCAGTGACACTTTTGGAAATAGCAGCATATCCACTTCTCTG
TCAGCCTCAAGCAGCATCATTGCAACAGATAATGTGTTATTCACACCCAGAGATAAACTAACAGTAGAAGAACTGGAACAATTTCAATCC
AAGAAATTTACTCTGGGAAAAATTCCATTAAAGCCTCCACCTCTGGAACTTCTAAATGTTTAAAAGGGCAATTTTAAATACAAAAAAGAA
TGATGTTTAAAATTGCTTTGAGTGATTCATACAGAGATGTATATATGCATACATGTATATATTCATAAGGAATATAAGCTTCCATCAATA
GTGATTTTAAATTTGATTTTTTTCTTAACTCTAAATATTTAAGTAAAAAGTAACAAAAACTCTGCAAGCAAGGGAATTTTTTTGTACTGT

>62290_62290_1_PACSIN2-NUPL2_PACSIN2_chr22_43308027_ENST00000263246_NUPL2_chr7_23224689_ENST00000258742_length(amino acids)=385AA_BP=2
MGGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPYFSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWE
SSGQWMFSVYSPVKKKPNISGFTDISPEELRLEYHNFLTSNNLQSYLNSVQRLINQWRNRVNELKSLNISTKVALLSDVKDGVNQAAPAF
GFGSSQAATFMSPGFPVNNSSSDNAQNFSFKTNSGFAAASSGSPAGFGSSPAFGAAASTSSGISTSAPAFGFGKPEVTSAASFSFKSPAA
SSFGSPGFSGLPASLATGPVRAPVAPAFGGGSSVAGFGSPGSHSHTAFSKPSSDTFGNSSISTSLSASSSIIATDNVLFTPRDKLTVEEL

--------------------------------------------------------------
>62290_62290_2_PACSIN2-NUPL2_PACSIN2_chr22_43308027_ENST00000263246_NUPL2_chr7_23224689_ENST00000410002_length(transcript)=773nt_BP=262nt
GCGGCCGCAGGGGTCTGGGCAGGGCTGGGCAGTGCTGCCGGAGCAAAAGCGGTAGCGGGAGCCCGGCCGGAGCTGGGTCTGGAGACGCCG
TGGCAGCCTGAACGGAGTGTGCGACGGATTGGGAGGTTTGTCTACAGATTTTGAGCGTTCGAAGTTGACCCCTGACTAAGTATACTTTGC
TGCTCCCTCAGCCTTTGAAAAAATGTCTGTCACATATGATGATTCCGTTGGAGTAGAAGTGTCCAGCGACAGCTTCTGGGAGGTAATAAT
AGACGTGGATGGAATACAACTAGCCAGAGATATTCCAATGTCATCCAGCCATCCAGTTTCTCCAAATCCACACCATGGGGGGGCAGCAGA
GATCAAGAAAAGCCATATTTCAGTTCTTTTGATTCTGGAGCTTCAACTAACAGGAAGGAAGGCTTTGGATTGTCTGAGAACCCATTTGCT
TCACTTAGTCCTGATGAGCAGAAAGATGAAAAGAAACTTCTGGAAGGAATTGTAAAAGATATGGAGGTTTGGGAATCATCAGGGCAGTGG
ATGTTTTCTGTTTATTCACCAGTGAAAAAGAAACCTAATATTTCAGTCCCTAAGCCCTTTCTGGGCTGAAACCTAGACCACCGGGCTTTC
CCAAGCCCACTCTGGGTGTTCCTGGGCCTCCGTCCTTTTGAGGAAACAGTGGGTACCTTGCAAATGGGAGCTCTTGCAATCAATATCGCA

>62290_62290_2_PACSIN2-NUPL2_PACSIN2_chr22_43308027_ENST00000263246_NUPL2_chr7_23224689_ENST00000410002_length(amino acids)=117AA_BP=2
MGGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPYFSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWE

--------------------------------------------------------------
>62290_62290_3_PACSIN2-NUPL2_PACSIN2_chr22_43308027_ENST00000337959_NUPL2_chr7_23224689_ENST00000258742_length(transcript)=1677nt_BP=262nt
GCGGCCGCAGGGGTCTGGGCAGGGCTGGGCAGTGCTGCCGGAGCAAAAGCGGTAGCGGGAGCCCGGCCGGAGCTGGGTCTGGAGACGCCG
TGGCAGCCTGAACGGAGTGTGCGACGGATTGGGAGGTTTGTCTACAGATTTTGAGCGTTCGAAGTTGACCCCTGACTAAGTATACTTTGC
TGCTCCCTCAGCCTTTGAAAAAATGTCTGTCACATATGATGATTCCGTTGGAGTAGAAGTGTCCAGCGACAGCTTCTGGGAGGTAATAAT
AGACGTGGATGGAATACAACTAGCCAGAGATATTCCAATGTCATCCAGCCATCCAGTTTCTCCAAATCCACACCATGGGGGGGCAGCAGA
GATCAAGAAAAGCCATATTTCAGTTCTTTTGATTCTGGAGCTTCAACTAACAGGAAGGAAGGCTTTGGATTGTCTGAGAACCCATTTGCT
TCACTTAGTCCTGATGAGCAGAAAGATGAAAAGAAACTTCTGGAAGGAATTGTAAAAGATATGGAGGTTTGGGAATCATCAGGGCAGTGG
ATGTTTTCTGTTTATTCACCAGTGAAAAAGAAACCTAATATTTCAGGTTTTACAGACATTTCACCAGAGGAATTGAGGCTTGAATACCAT
AACTTCTTAACCAGCAATAACTTACAGAGTTATCTAAATTCTGTCCAACGTTTAATAAATCAATGGAGGAACAGGGTAAATGAACTGAAA
AGTCTAAATATATCAACTAAAGTAGCTTTGCTCTCTGATGTAAAGGATGGAGTAAATCAAGCAGCACCTGCATTTGGATTTGGCAGCAGT
CAAGCAGCAACATTTATGTCGCCAGGCTTTCCAGTCAATAACAGCAGCAGTGATAATGCTCAGAACTTTAGTTTTAAAACAAACTCTGGA
TTTGCTGCTGCCTCTTCTGGAAGCCCTGCTGGTTTTGGGAGTTCCCCAGCATTTGGAGCTGCAGCCTCTACCAGTTCAGGTATCTCTACT
TCTGCTCCAGCTTTTGGATTTGGGAAGCCTGAAGTCACATCGGCTGCATCATTTTCATTCAAAAGCCCTGCAGCTTCCAGTTTTGGATCA
CCTGGATTTTCAGGACTTCCAGCTTCCTTGGCAACAGGTCCTGTCAGAGCTCCAGTGGCCCCAGCCTTTGGAGGTGGCAGTTCTGTGGCT
GGTTTTGGTAGTCCGGGCTCACATTCTCACACTGCTTTTTCTAAGCCATCCAGTGACACTTTTGGAAATAGCAGCATATCCACTTCTCTG
TCAGCCTCAAGCAGCATCATTGCAACAGATAATGTGTTATTCACACCCAGAGATAAACTAACAGTAGAAGAACTGGAACAATTTCAATCC
AAGAAATTTACTCTGGGAAAAATTCCATTAAAGCCTCCACCTCTGGAACTTCTAAATGTTTAAAAGGGCAATTTTAAATACAAAAAAGAA
TGATGTTTAAAATTGCTTTGAGTGATTCATACAGAGATGTATATATGCATACATGTATATATTCATAAGGAATATAAGCTTCCATCAATA
GTGATTTTAAATTTGATTTTTTTCTTAACTCTAAATATTTAAGTAAAAAGTAACAAAAACTCTGCAAGCAAGGGAATTTTTTTGTACTGT

>62290_62290_3_PACSIN2-NUPL2_PACSIN2_chr22_43308027_ENST00000337959_NUPL2_chr7_23224689_ENST00000258742_length(amino acids)=385AA_BP=2
MGGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPYFSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWE
SSGQWMFSVYSPVKKKPNISGFTDISPEELRLEYHNFLTSNNLQSYLNSVQRLINQWRNRVNELKSLNISTKVALLSDVKDGVNQAAPAF
GFGSSQAATFMSPGFPVNNSSSDNAQNFSFKTNSGFAAASSGSPAGFGSSPAFGAAASTSSGISTSAPAFGFGKPEVTSAASFSFKSPAA
SSFGSPGFSGLPASLATGPVRAPVAPAFGGGSSVAGFGSPGSHSHTAFSKPSSDTFGNSSISTSLSASSSIIATDNVLFTPRDKLTVEEL

--------------------------------------------------------------
>62290_62290_4_PACSIN2-NUPL2_PACSIN2_chr22_43308027_ENST00000337959_NUPL2_chr7_23224689_ENST00000410002_length(transcript)=773nt_BP=262nt
GCGGCCGCAGGGGTCTGGGCAGGGCTGGGCAGTGCTGCCGGAGCAAAAGCGGTAGCGGGAGCCCGGCCGGAGCTGGGTCTGGAGACGCCG
TGGCAGCCTGAACGGAGTGTGCGACGGATTGGGAGGTTTGTCTACAGATTTTGAGCGTTCGAAGTTGACCCCTGACTAAGTATACTTTGC
TGCTCCCTCAGCCTTTGAAAAAATGTCTGTCACATATGATGATTCCGTTGGAGTAGAAGTGTCCAGCGACAGCTTCTGGGAGGTAATAAT
AGACGTGGATGGAATACAACTAGCCAGAGATATTCCAATGTCATCCAGCCATCCAGTTTCTCCAAATCCACACCATGGGGGGGCAGCAGA
GATCAAGAAAAGCCATATTTCAGTTCTTTTGATTCTGGAGCTTCAACTAACAGGAAGGAAGGCTTTGGATTGTCTGAGAACCCATTTGCT
TCACTTAGTCCTGATGAGCAGAAAGATGAAAAGAAACTTCTGGAAGGAATTGTAAAAGATATGGAGGTTTGGGAATCATCAGGGCAGTGG
ATGTTTTCTGTTTATTCACCAGTGAAAAAGAAACCTAATATTTCAGTCCCTAAGCCCTTTCTGGGCTGAAACCTAGACCACCGGGCTTTC
CCAAGCCCACTCTGGGTGTTCCTGGGCCTCCGTCCTTTTGAGGAAACAGTGGGTACCTTGCAAATGGGAGCTCTTGCAATCAATATCGCA

>62290_62290_4_PACSIN2-NUPL2_PACSIN2_chr22_43308027_ENST00000337959_NUPL2_chr7_23224689_ENST00000410002_length(amino acids)=117AA_BP=2
MGGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPYFSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWE

--------------------------------------------------------------
>62290_62290_5_PACSIN2-NUPL2_PACSIN2_chr22_43308027_ENST00000403744_NUPL2_chr7_23224689_ENST00000258742_length(transcript)=1697nt_BP=282nt
CTGTCCCACTGGGCAGGTGCCTCTGACGGAGAGGAGGCGTCGTCGGGAAGTATGTGGCCGTGGCTGCTCTGGCATGATCCTGAAGACTGG
CACGAAGGGGAATGGAGCCGCACAGAGAATTTCAGGCATCAGAGGGGAAGCGCAGGTTTGTCTACAGATTTTGAGCGTTCGAAGTTGACC
CCTGACTAAGTATACTTTGCTGCTCCCTCAGCCTTTGAAAAAATGTCTGTCACATATGATGATTCCGTTGGAGTAGAAGTGTCCAGCGAC
AGCTTCTGGGAGGTAATAATAGACGTGGATGGAATACAACTAGCCAGAGATATTCCAATGTCATCCAGCCATCCAGTTTCTCCAAATCCA
CACCATGGGGGGGCAGCAGAGATCAAGAAAAGCCATATTTCAGTTCTTTTGATTCTGGAGCTTCAACTAACAGGAAGGAAGGCTTTGGAT
TGTCTGAGAACCCATTTGCTTCACTTAGTCCTGATGAGCAGAAAGATGAAAAGAAACTTCTGGAAGGAATTGTAAAAGATATGGAGGTTT
GGGAATCATCAGGGCAGTGGATGTTTTCTGTTTATTCACCAGTGAAAAAGAAACCTAATATTTCAGGTTTTACAGACATTTCACCAGAGG
AATTGAGGCTTGAATACCATAACTTCTTAACCAGCAATAACTTACAGAGTTATCTAAATTCTGTCCAACGTTTAATAAATCAATGGAGGA
ACAGGGTAAATGAACTGAAAAGTCTAAATATATCAACTAAAGTAGCTTTGCTCTCTGATGTAAAGGATGGAGTAAATCAAGCAGCACCTG
CATTTGGATTTGGCAGCAGTCAAGCAGCAACATTTATGTCGCCAGGCTTTCCAGTCAATAACAGCAGCAGTGATAATGCTCAGAACTTTA
GTTTTAAAACAAACTCTGGATTTGCTGCTGCCTCTTCTGGAAGCCCTGCTGGTTTTGGGAGTTCCCCAGCATTTGGAGCTGCAGCCTCTA
CCAGTTCAGGTATCTCTACTTCTGCTCCAGCTTTTGGATTTGGGAAGCCTGAAGTCACATCGGCTGCATCATTTTCATTCAAAAGCCCTG
CAGCTTCCAGTTTTGGATCACCTGGATTTTCAGGACTTCCAGCTTCCTTGGCAACAGGTCCTGTCAGAGCTCCAGTGGCCCCAGCCTTTG
GAGGTGGCAGTTCTGTGGCTGGTTTTGGTAGTCCGGGCTCACATTCTCACACTGCTTTTTCTAAGCCATCCAGTGACACTTTTGGAAATA
GCAGCATATCCACTTCTCTGTCAGCCTCAAGCAGCATCATTGCAACAGATAATGTGTTATTCACACCCAGAGATAAACTAACAGTAGAAG
AACTGGAACAATTTCAATCCAAGAAATTTACTCTGGGAAAAATTCCATTAAAGCCTCCACCTCTGGAACTTCTAAATGTTTAAAAGGGCA
ATTTTAAATACAAAAAAGAATGATGTTTAAAATTGCTTTGAGTGATTCATACAGAGATGTATATATGCATACATGTATATATTCATAAGG
AATATAAGCTTCCATCAATAGTGATTTTAAATTTGATTTTTTTCTTAACTCTAAATATTTAAGTAAAAAGTAACAAAAACTCTGCAAGCA

>62290_62290_5_PACSIN2-NUPL2_PACSIN2_chr22_43308027_ENST00000403744_NUPL2_chr7_23224689_ENST00000258742_length(amino acids)=385AA_BP=2
MGGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPYFSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWE
SSGQWMFSVYSPVKKKPNISGFTDISPEELRLEYHNFLTSNNLQSYLNSVQRLINQWRNRVNELKSLNISTKVALLSDVKDGVNQAAPAF
GFGSSQAATFMSPGFPVNNSSSDNAQNFSFKTNSGFAAASSGSPAGFGSSPAFGAAASTSSGISTSAPAFGFGKPEVTSAASFSFKSPAA
SSFGSPGFSGLPASLATGPVRAPVAPAFGGGSSVAGFGSPGSHSHTAFSKPSSDTFGNSSISTSLSASSSIIATDNVLFTPRDKLTVEEL

--------------------------------------------------------------
>62290_62290_6_PACSIN2-NUPL2_PACSIN2_chr22_43308027_ENST00000403744_NUPL2_chr7_23224689_ENST00000410002_length(transcript)=793nt_BP=282nt
CTGTCCCACTGGGCAGGTGCCTCTGACGGAGAGGAGGCGTCGTCGGGAAGTATGTGGCCGTGGCTGCTCTGGCATGATCCTGAAGACTGG
CACGAAGGGGAATGGAGCCGCACAGAGAATTTCAGGCATCAGAGGGGAAGCGCAGGTTTGTCTACAGATTTTGAGCGTTCGAAGTTGACC
CCTGACTAAGTATACTTTGCTGCTCCCTCAGCCTTTGAAAAAATGTCTGTCACATATGATGATTCCGTTGGAGTAGAAGTGTCCAGCGAC
AGCTTCTGGGAGGTAATAATAGACGTGGATGGAATACAACTAGCCAGAGATATTCCAATGTCATCCAGCCATCCAGTTTCTCCAAATCCA
CACCATGGGGGGGCAGCAGAGATCAAGAAAAGCCATATTTCAGTTCTTTTGATTCTGGAGCTTCAACTAACAGGAAGGAAGGCTTTGGAT
TGTCTGAGAACCCATTTGCTTCACTTAGTCCTGATGAGCAGAAAGATGAAAAGAAACTTCTGGAAGGAATTGTAAAAGATATGGAGGTTT
GGGAATCATCAGGGCAGTGGATGTTTTCTGTTTATTCACCAGTGAAAAAGAAACCTAATATTTCAGTCCCTAAGCCCTTTCTGGGCTGAA
ACCTAGACCACCGGGCTTTCCCAAGCCCACTCTGGGTGTTCCTGGGCCTCCGTCCTTTTGAGGAAACAGTGGGTACCTTGCAAATGGGAG

>62290_62290_6_PACSIN2-NUPL2_PACSIN2_chr22_43308027_ENST00000403744_NUPL2_chr7_23224689_ENST00000410002_length(amino acids)=117AA_BP=2
MGGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPYFSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PACSIN2-NUPL2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	NUPL2	chr22:43308027	chr7:23224689	ENST00000258742		0	7	365_423	40.333333333333336	424.0	GLE1
Tgene	NUPL2	chr22:43308027	chr7:23224689	ENST00000258742		0	7	94_170	40.333333333333336	424.0	HIV-1 Vpr

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PACSIN2-NUPL2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PACSIN2-NUPL2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source