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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ARHGEF18-HSCB (FusionGDB2 ID:6237) |
Fusion Gene Summary for ARHGEF18-HSCB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGEF18-HSCB | Fusion gene ID: 6237 | Hgene | Tgene | Gene symbol | ARHGEF18 | HSCB | Gene ID | 23370 | 150274 |
| Gene name | Rho/Rac guanine nucleotide exchange factor 18 | HscB mitochondrial iron-sulfur cluster cochaperone | |
| Synonyms | P114-RhoGEF|RP78|SA-RhoGEF|p114RhoGEF | DNAJC20|HSC20|JAC1 | |
| Cytomap | 19p13.2 | 22q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho guanine nucleotide exchange factor 18114 kDa Rho-specific guanine nucleotide exchange factorRho-specific guanine nucleotide exchange factor p114Rho/Rac guanine nucleotide exchange factor (GEF) 18septin-associated RhoGEF | iron-sulfur cluster co-chaperone protein HscBDnaJ (Hsp40) homolog, subfamily C, member 20HscB iron-sulfur cluster co-chaperone homologHscB mitochondrial iron-sulfur cluster co-chaperoneJ-type co-chaperone HSC20epididymis secretory sperm binding prote | |
| Modification date | 20200320 | 20200320 | |
| UniProtAcc | Q6ZSZ5 | Q8IWL3 | |
| Ensembl transtripts involved in fusion gene | ENST00000319670, ENST00000359920, | ENST00000398941, ENST00000495977, ENST00000216027, | |
| Fusion gene scores | * DoF score | 14 X 8 X 12=1344 | 12 X 9 X 8=864 |
| # samples | 16 | 18 | |
| ** MAII score | log2(16/1344*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/864*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARHGEF18 [Title/Abstract] AND HSCB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ARHGEF18(7516152)-HSCB(29153064), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARHGEF18 | GO:0007264 | small GTPase mediated signal transduction | 14512443 |
| Hgene | ARHGEF18 | GO:0008360 | regulation of cell shape | 14512443 |
| Hgene | ARHGEF18 | GO:0030036 | actin cytoskeleton organization | 14512443 |
| Fusion gene breakpoints across ARHGEF18 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across HSCB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | CR993366 | ARHGEF18 | chr19 | 7516152 | + | HSCB | chr22 | 29153064 | + |
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Fusion Gene ORF analysis for ARHGEF18-HSCB |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000319670 | ENST00000398941 | ARHGEF18 | chr19 | 7516152 | + | HSCB | chr22 | 29153064 | + |
| 5CDS-3UTR | ENST00000319670 | ENST00000495977 | ARHGEF18 | chr19 | 7516152 | + | HSCB | chr22 | 29153064 | + |
| 5CDS-3UTR | ENST00000359920 | ENST00000398941 | ARHGEF18 | chr19 | 7516152 | + | HSCB | chr22 | 29153064 | + |
| 5CDS-3UTR | ENST00000359920 | ENST00000495977 | ARHGEF18 | chr19 | 7516152 | + | HSCB | chr22 | 29153064 | + |
| In-frame | ENST00000319670 | ENST00000216027 | ARHGEF18 | chr19 | 7516152 | + | HSCB | chr22 | 29153064 | + |
| In-frame | ENST00000359920 | ENST00000216027 | ARHGEF18 | chr19 | 7516152 | + | HSCB | chr22 | 29153064 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000319670 | ARHGEF18 | chr19 | 7516152 | + | ENST00000216027 | HSCB | chr22 | 29153064 | + | 1456 | 1023 | 80 | 1114 | 344 |
| ENST00000359920 | ARHGEF18 | chr19 | 7516152 | + | ENST00000216027 | HSCB | chr22 | 29153064 | + | 1977 | 1544 | 253 | 1635 | 460 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000319670 | ENST00000216027 | ARHGEF18 | chr19 | 7516152 | + | HSCB | chr22 | 29153064 | + | 0.003084054 | 0.99691594 |
| ENST00000359920 | ENST00000216027 | ARHGEF18 | chr19 | 7516152 | + | HSCB | chr22 | 29153064 | + | 0.004012618 | 0.99598736 |
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Fusion Genomic Features for ARHGEF18-HSCB |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ARHGEF18 | chr19 | 7516152 | + | HSCB | chr22 | 29153065 | + | 5.31E-07 | 0.9999995 |
| ARHGEF18 | chr19 | 7516152 | + | HSCB | chr22 | 29153065 | + | 5.31E-07 | 0.9999995 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ARHGEF18-HSCB |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:7516152/chr22:29153064) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGEF18 | HSCB |
| FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}. | FUNCTION: Acts as a co-chaperone in iron-sulfur cluster assembly in both mitochondria and the cytoplasm (PubMed:20668094, PubMed:29309586). Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain (PubMed:26749241). Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 (PubMed:26749241). Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1 (PubMed:29309586). This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT (PubMed:29309586). {ECO:0000269|PubMed:20668094, ECO:0000269|PubMed:26749241, ECO:0000269|PubMed:29309586}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ARHGEF18 | chr19:7516152 | chr22:29153064 | ENST00000359920 | + | 6 | 20 | 310_334 | 430 | 1556.0 | Zinc finger | C2H2-type%3B degenerate |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ARHGEF18 | chr19:7516152 | chr22:29153064 | ENST00000319670 | + | 7 | 21 | 1038_1148 | 272 | 1618.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ARHGEF18 | chr19:7516152 | chr22:29153064 | ENST00000359920 | + | 6 | 20 | 1038_1148 | 430 | 1556.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ARHGEF18 | chr19:7516152 | chr22:29153064 | ENST00000319670 | + | 7 | 21 | 1042_1142 | 272 | 1618.0 | Compositional bias | Arg-rich |
| Hgene | ARHGEF18 | chr19:7516152 | chr22:29153064 | ENST00000319670 | + | 7 | 21 | 1292_1346 | 272 | 1618.0 | Compositional bias | Pro-rich |
| Hgene | ARHGEF18 | chr19:7516152 | chr22:29153064 | ENST00000359920 | + | 6 | 20 | 1042_1142 | 430 | 1556.0 | Compositional bias | Arg-rich |
| Hgene | ARHGEF18 | chr19:7516152 | chr22:29153064 | ENST00000359920 | + | 6 | 20 | 1292_1346 | 430 | 1556.0 | Compositional bias | Pro-rich |
| Hgene | ARHGEF18 | chr19:7516152 | chr22:29153064 | ENST00000319670 | + | 7 | 21 | 447_644 | 272 | 1618.0 | Domain | DH |
| Hgene | ARHGEF18 | chr19:7516152 | chr22:29153064 | ENST00000319670 | + | 7 | 21 | 684_786 | 272 | 1618.0 | Domain | PH |
| Hgene | ARHGEF18 | chr19:7516152 | chr22:29153064 | ENST00000359920 | + | 6 | 20 | 447_644 | 430 | 1556.0 | Domain | DH |
| Hgene | ARHGEF18 | chr19:7516152 | chr22:29153064 | ENST00000359920 | + | 6 | 20 | 684_786 | 430 | 1556.0 | Domain | PH |
| Hgene | ARHGEF18 | chr19:7516152 | chr22:29153064 | ENST00000319670 | + | 7 | 21 | 310_334 | 272 | 1618.0 | Zinc finger | C2H2-type%3B degenerate |
| Tgene | HSCB | chr19:7516152 | chr22:29153064 | ENST00000216027 | 4 | 6 | 72_144 | 205 | 236.0 | Domain | Note=J |
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Fusion Gene Sequence for ARHGEF18-HSCB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >6237_6237_1_ARHGEF18-HSCB_ARHGEF18_chr19_7516152_ENST00000319670_HSCB_chr22_29153064_ENST00000216027_length(transcript)=1456nt_BP=1023nt CTCGCGCGGCTTCCCGCTTCCGGCTCCCAGCTGCTAGCTACTGTGGATCTGGGGGGGCCGGACGGAGGCATCGGAGGCGGCTGCGAGAGT GGCAGAGGAGCTGGCGGAGAGCGGCCTGCGGGCGATCGGGCCGAGCCTCGCTCAAGGAGCACCCCCGGGGCACCCTCCTGTCCGATGGCA GCCCGGCCCTGTCCAGGAATGTCGGTATGACGGTCTCTCAGAAAGGGGGTCCCCAGCCAACACCGAGCCCGGCTGGCCCTGGGACGCAAC TCGGACCAATCACAGGAGAGATGGATGAAGCCGATTCTGCGTTTTTAAAATTTAAGCAGACAGCTGATGACTCTCTGTCCCTTACATCTC CAAACACCGAGTCCATTTTTGTAGAAGATCCCTACACCGCCTCGCTGAGGAGTGAGATTGAGTCAGACGGCCACGAGTTTGAAGCTGAGT CCTGGAGCCTCGCCGTGGATGCAGCCTACGCCAAGAAGCAAAAGAGGGAGGTGGTGAAAAGACAAGATGTCCTTTATGAGCTGATGCAGA CAGAGGTGCACCACGTGCGGACGCTCAAGATCATGCTGAAGGTGTACTCCAGGGCCCTGCAGGAGGAGCTGCAGTTCAGCAGCAAGGCCA TTGGCCGCCTCTTCCCATGCGCTGACGACCTGCTGGAGACGCACAGCCACTTCCTCGCTCGGCTCAAGGAGCGCCGCCAGGAGTCCCTGG AGGAGGGCAGTGACCGGAATTATGTCATCCAGAAAATCGGCGACCTCCTGGTTCAGCAGTTTTCAGGTGAAAATGGGGAGAGAATGAAAG AAAAGTACGGTGTGTTTTGTAGTGGCCACAATGAAGCTGTTAGTCATTACAAGTTGCTGCTTCAGCAAAACAAGAAATTTCAAAACTTGA TCAAGAAAATTGGCAACTTCTCCATCGTGCGGCGGCTTGGCGTGCAGGAGTGCATTCTCCTGGTTACACAACGCATAACCAAATACCCAG TGCTGGTGGAGCGCATCATCCAGAACACGGAAGATGACTTTGAAGAAGCCAAGGAAATTTTGACAAAGATGAGATACTTTTCAAATATAG AAGAAAAGATCAAGTTAAAGAAGATTCCCCTTTAATTGTGGATAGTTTAAAGTTTAAAAAATAAAGTTCTTGCTGGGCACAGTGGCTCAC ACCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATGACAAGGTCAGGAGTTCAAGACCAGCTTGGCCAACATAGTGAAACCCCG TCTCTGCTGAAAATACAAAAATTAGCCGGGCATGGTGGCGCGTGCCTGTAATCCCAGCTACTTGGTAGGCCGAGGCAGGAGAATCGCTTA AACCCGTGAGGTGGAGGTTGCAGTGAGCAGAGATCACGCAACTGCACTCCAGCTTGGGCAACAGAGTGAGACTTAATCTTGAAAAATAAA >6237_6237_1_ARHGEF18-HSCB_ARHGEF18_chr19_7516152_ENST00000319670_HSCB_chr22_29153064_ENST00000216027_length(amino acids)=344AA_BP=314 MREWQRSWRRAACGRSGRASLKEHPRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLS LTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFS SKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKF -------------------------------------------------------------- >6237_6237_2_ARHGEF18-HSCB_ARHGEF18_chr19_7516152_ENST00000359920_HSCB_chr22_29153064_ENST00000216027_length(transcript)=1977nt_BP=1544nt AAACACCATGCCCTGCCATCTCTGGGTCTTAGAGTCACCCTAACATCTGATCTAGATTAATTATCATCATGTGCGAGGTTTTGGCATGAA GCACGCCAGGCTCACCGTTTCATGATCTTAGACTATTTACAGCAAACTCAAACAGCTCACTTGCTTTTTACACCCTGCAAAGACCAAGGG AGAGCCTGGAGGGGTTGTTTTTTTTTTCTGTTTTATTCTATCAAAGCAGCAAATACTGCAATTTCCACAGTAAATGGTCACAGTGGGGAC CAATATCCTGCCCTCCAGACCCGCTGCTTCAGCCAATACAGCAAGGGAAGACGCAGCTCTGTTTTCTAGAAGGATCCCACCGAGGCATAA AAACGGCGCAGCCCAGCCTGGCGCCGCGCCGGGTCCCGGAGCCCCGGGCGCGAACATGGGGAATGCGCACTCCAAAAGCGGGGACAGGCA CAGCGCGCTCCCCGGCCGCCCCGAGCTGTCTTTTTACGGCTCTTTCCCCAGGAAATGGAGCGAGAACGTCTTCTTGGATAACGAGCTGCT GACCTCCAAGATCCTGTCTGTGCTGCGGCCGCAGTCGGAGCGGGGCTTCCGCGCCGGGGACCTCCGCTACCCGACCCACTTTCTCAGCAC CAACTCTGTCCTTGCCTCTGTCACAGCCTCGCTCAAGGAGCACCCCCGGGGCACCCTCCTGTCCGATGGCAGCCCGGCCCTGTCCAGGAA TGTCGGTATGACGGTCTCTCAGAAAGGGGGTCCCCAGCCAACACCGAGCCCGGCTGGCCCTGGGACGCAACTCGGACCAATCACAGGAGA GATGGATGAAGCCGATTCTGCGTTTTTAAAATTTAAGCAGACAGCTGATGACTCTCTGTCCCTTACATCTCCAAACACCGAGTCCATTTT TGTAGAAGATCCCTACACCGCCTCGCTGAGGAGTGAGATTGAGTCAGACGGCCACGAGTTTGAAGCTGAGTCCTGGAGCCTCGCCGTGGA TGCAGCCTACGCCAAGAAGCAAAAGAGGGAGGTGGTGAAAAGACAAGATGTCCTTTATGAGCTGATGCAGACAGAGGTGCACCACGTGCG GACGCTCAAGATCATGCTGAAGGTGTACTCCAGGGCCCTGCAGGAGGAGCTGCAGTTCAGCAGCAAGGCCATTGGCCGCCTCTTCCCATG CGCTGACGACCTGCTGGAGACGCACAGCCACTTCCTCGCTCGGCTCAAGGAGCGCCGCCAGGAGTCCCTGGAGGAGGGCAGTGACCGGAA TTATGTCATCCAGAAAATCGGCGACCTCCTGGTTCAGCAGTTTTCAGGTGAAAATGGGGAGAGAATGAAAGAAAAGTACGGTGTGTTTTG TAGTGGCCACAATGAAGCTGTTAGTCATTACAAGTTGCTGCTTCAGCAAAACAAGAAATTTCAAAACTTGATCAAGAAAATTGGCAACTT CTCCATCGTGCGGCGGCTTGGCGTGCAGGAGTGCATTCTCCTGGTTACACAACGCATAACCAAATACCCAGTGCTGGTGGAGCGCATCAT CCAGAACACGGAAGATGACTTTGAAGAAGCCAAGGAAATTTTGACAAAGATGAGATACTTTTCAAATATAGAAGAAAAGATCAAGTTAAA GAAGATTCCCCTTTAATTGTGGATAGTTTAAAGTTTAAAAAATAAAGTTCTTGCTGGGCACAGTGGCTCACACCTGTAATCCCAGCACTT TGGGAGGCTGAGGTGGGTGGATGACAAGGTCAGGAGTTCAAGACCAGCTTGGCCAACATAGTGAAACCCCGTCTCTGCTGAAAATACAAA AATTAGCCGGGCATGGTGGCGCGTGCCTGTAATCCCAGCTACTTGGTAGGCCGAGGCAGGAGAATCGCTTAAACCCGTGAGGTGGAGGTT >6237_6237_2_ARHGEF18-HSCB_ARHGEF18_chr19_7516152_ENST00000359920_HSCB_chr22_29153064_ENST00000216027_length(amino acids)=460AA_BP=430 MVTVGTNILPSRPAASANTAREDAALFSRRIPPRHKNGAAQPGAAPGPGAPGANMGNAHSKSGDRHSALPGRPELSFYGSFPRKWSENVF LDNELLTSKILSVLRPQSERGFRAGDLRYPTHFLSTNSVLASVTASLKEHPRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQL GPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQT EVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEDDFEEAKEILTKMRYFSNIE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ARHGEF18-HSCB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARHGEF18-HSCB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARHGEF18-HSCB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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