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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PAK1-ARHGEF18 (FusionGDB2 ID:62397)

Fusion Gene Summary for PAK1-ARHGEF18

check button Fusion gene summary
Fusion gene informationFusion gene name: PAK1-ARHGEF18
Fusion gene ID: 62397
HgeneTgene
Gene symbol

PAK1

ARHGEF18

Gene ID

5585

23370

Gene nameprotein kinase N1Rho/Rac guanine nucleotide exchange factor 18
SynonymsDBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1P114-RhoGEF|RP78|SA-RhoGEF|p114RhoGEF
Cytomap

19p13.12

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase N1protease-activated kinase 1protein kinase C-like 1protein kinase C-like PKNprotein kinase C-related kinase 1protein kinase PKN-alphaserine-threonine kinase Nserine/threonine protein kinase Nrho guanine nucleotide exchange factor 18114 kDa Rho-specific guanine nucleotide exchange factorRho-specific guanine nucleotide exchange factor p114Rho/Rac guanine nucleotide exchange factor (GEF) 18septin-associated RhoGEF
Modification date2020032920200320
UniProtAcc.

Q6ZSZ5

Ensembl transtripts involved in fusion geneENST00000525542, ENST00000278568, 
ENST00000356341, ENST00000528203, 
ENST00000530617, 		ENST00000319670, 
ENST00000359920, 
Fusion gene scores* DoF score31 X 18 X 9=50228 X 8 X 2=128
# samples 368
** MAII scorelog2(36/5022*10)=-3.80219321694183
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/128*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAK1 [Title/Abstract] AND ARHGEF18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPAK1(77043775)-ARHGEF18(7521213), # samples:3
Anticipated loss of major functional domain due to fusion event.PAK1-ARHGEF18 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PAK1-ARHGEF18 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
PAK1-ARHGEF18 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAK1

GO:0006357

regulation of transcription by RNA polymerase II

12514133

HgenePAK1

GO:0006468

protein phosphorylation

17332740

HgenePAK1

GO:0035407

histone H3-T11 phosphorylation

18066052

TgeneARHGEF18

GO:0007264

small GTPase mediated signal transduction

14512443

TgeneARHGEF18

GO:0008360

regulation of cell shape

14512443

TgeneARHGEF18

GO:0030036

actin cytoskeleton organization

14512443


check buttonFusion gene breakpoints across PAK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGEF18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AQ-A04L-01BPAK1chr11

77043775

-ARHGEF18chr19

7521213

+


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Fusion Gene ORF analysis for PAK1-ARHGEF18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000525542ENST00000319670PAK1chr11

77043775

-ARHGEF18chr19

7521213

+
5UTR-3CDSENST00000525542ENST00000359920PAK1chr11

77043775

-ARHGEF18chr19

7521213

+
Frame-shiftENST00000278568ENST00000319670PAK1chr11

77043775

-ARHGEF18chr19

7521213

+
Frame-shiftENST00000278568ENST00000359920PAK1chr11

77043775

-ARHGEF18chr19

7521213

+
Frame-shiftENST00000356341ENST00000319670PAK1chr11

77043775

-ARHGEF18chr19

7521213

+
Frame-shiftENST00000356341ENST00000359920PAK1chr11

77043775

-ARHGEF18chr19

7521213

+
Frame-shiftENST00000528203ENST00000319670PAK1chr11

77043775

-ARHGEF18chr19

7521213

+
Frame-shiftENST00000528203ENST00000359920PAK1chr11

77043775

-ARHGEF18chr19

7521213

+
In-frameENST00000530617ENST00000319670PAK1chr11

77043775

-ARHGEF18chr19

7521213

+
In-frameENST00000530617ENST00000359920PAK1chr11

77043775

-ARHGEF18chr19

7521213

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000530617PAK1chr1177043775-ENST00000319670ARHGEF18chr197521213+5803186318683844658
ENST00000530617PAK1chr1177043775-ENST00000359920ARHGEF18chr197521213+5803186318683844658

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000530617ENST00000319670PAK1chr1177043775-ARHGEF18chr197521213+0.0162597260.98374027
ENST00000530617ENST00000359920PAK1chr1177043775-ARHGEF18chr197521213+0.0162597260.98374027

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Fusion Genomic Features for PAK1-ARHGEF18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PAK1chr1177043774-ARHGEF18chr197521212+2.14E-050.99997866
PAK1chr1177043774-ARHGEF18chr197521212+2.14E-050.99997866

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PAK1-ARHGEF18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:77043775/chr19:7521213)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARHGEF18

Q6ZSZ5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAK1chr11:77043775chr19:7521213ENST00000278568-141675_88517554.0DomainCRIB
HgenePAK1chr11:77043775chr19:7521213ENST00000356341-141575_88517546.0DomainCRIB
HgenePAK1chr11:77043775chr19:7521213ENST00000278568-1416276_284517554.0Nucleotide bindingNote=ATP
HgenePAK1chr11:77043775chr19:7521213ENST00000278568-1416345_347517554.0Nucleotide bindingNote=ATP
HgenePAK1chr11:77043775chr19:7521213ENST00000356341-1415276_284517546.0Nucleotide bindingNote=ATP
HgenePAK1chr11:77043775chr19:7521213ENST00000356341-1415345_347517546.0Nucleotide bindingNote=ATP
HgenePAK1chr11:77043775chr19:7521213ENST00000278568-141670_140517554.0RegionNote=Autoregulatory region
HgenePAK1chr11:77043775chr19:7521213ENST00000278568-141675_105517554.0RegionNote=GTPase-binding
HgenePAK1chr11:77043775chr19:7521213ENST00000356341-141570_140517546.0RegionNote=Autoregulatory region
HgenePAK1chr11:77043775chr19:7521213ENST00000356341-141575_105517546.0RegionNote=GTPase-binding
TgeneARHGEF18chr11:77043775chr19:7521213ENST000003196707211038_11483551618.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF18chr11:77043775chr19:7521213ENST000003599206201038_11485131556.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF18chr11:77043775chr19:7521213ENST000003196707211042_11423551618.0Compositional biasArg-rich
TgeneARHGEF18chr11:77043775chr19:7521213ENST000003196707211292_13463551618.0Compositional biasPro-rich
TgeneARHGEF18chr11:77043775chr19:7521213ENST000003599206201042_11425131556.0Compositional biasArg-rich
TgeneARHGEF18chr11:77043775chr19:7521213ENST000003599206201292_13465131556.0Compositional biasPro-rich
TgeneARHGEF18chr11:77043775chr19:7521213ENST00000319670721447_6443551618.0DomainDH
TgeneARHGEF18chr11:77043775chr19:7521213ENST00000319670721684_7863551618.0DomainPH
TgeneARHGEF18chr11:77043775chr19:7521213ENST00000359920620684_7865131556.0DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAK1chr11:77043775chr19:7521213ENST00000278568-1416270_521517554.0DomainProtein kinase
HgenePAK1chr11:77043775chr19:7521213ENST00000356341-1415270_521517546.0DomainProtein kinase
TgeneARHGEF18chr11:77043775chr19:7521213ENST00000359920620447_6445131556.0DomainDH
TgeneARHGEF18chr11:77043775chr19:7521213ENST00000319670721310_3343551618.0Zinc fingerC2H2-type%3B degenerate
TgeneARHGEF18chr11:77043775chr19:7521213ENST00000359920620310_3345131556.0Zinc fingerC2H2-type%3B degenerate


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Fusion Gene Sequence for PAK1-ARHGEF18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>62397_62397_1_PAK1-ARHGEF18_PAK1_chr11_77043775_ENST00000530617_ARHGEF18_chr19_7521213_ENST00000319670_length(transcript)=5803nt_BP=1863nt
TGCTTTGCAGAAAAGGAGAAGCGCGCGGCTTCCTCCCGCCTCCTTCCCTCCTTTCTTCCCCCGCCCCTTCTGTTTCGCCAACCCCGACGC
GGCGCCTTCGCTGCCGCCCTGCGAGAGCGCGAGCGTGCTGCACCTCGGGAGCTGGCGGCTGAGCTGCCAGGAGCCCAGCCCAGCTGAATC
GAGCGGAGCCGGTGGAGCAGGGGCCTTGTGGGTACCCGGTTGGGCAGGGAGAGGTGCGGCTCTGCGACGGAAACAATCGCCAGAGATGCC
GGGGCTAGCCTTCCCCACCAGTAGCTGCTGCTGGTGGTGACAATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCG
ATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGATGCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAG
GAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCTGGAGATAAAACAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCT
CTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGATGCTGTCACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTG
CTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACA
TCCAACAGCCAGAAATACATGAGCTTTACAGATAAGTCAGCTGAGGATTACAATTCTTCTAATGCCTTGAATGTGAAGGCTGTGTCTGAG
ACTCCTGCAGTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGATGATGCTACCCCACCACCAGTGATTGCTCCACGCCCAGAGCAC
ACAAAATCTGTATACACACGGTCTGTGATTGAACCACTTCCTGTCACTCCAACTCGGGACGTGGCTACATCTCCCATTTCACCTACTGAA
AATAACACCACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAGAAGAAGAAGCCTAAAATGTCTGATGAGGAGATCTTGGAGAAA
TTACGAAGCATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGGTTTGAGAAGATTGGACAAGGTGCTTCAGGCACCGTGTACACA
GCAATGGATGTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAATCTTCAGCAGCAGCCCAAGAAAGAGCTGATTATTAATGAGATC
CTGGTCATGAGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGACAGTTACCTCGTGGGAGATGAGCTGTGGGTTGTTATGGAATAC
TTGGCTGGAGGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGATGAAGGCCAAATTGCAGCTGTGTGCCGTGAGTGTCTGCAGGCT
CTGGAGTTCTTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGTGACAATATTCTGTTGGGAATGGATGGCTCTGTCAAGCTAACT
GACTTTGGATTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGCACCATGGTAGGAACCCCATACTGGATGGCACCAGAGGTTGTG
ACACGAAAGGCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATCATGGCCATCGAAATGATTGAAGGGGAGCCTCCATACCTCAAT
GAAAACCCTCTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCAGAACTTCAGAACCCAGAGAAGCTGTCAGCTATCTTCCGGGAC
TTTCTGAACCGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCTAAAGAGCTGCTACAGATATCCTGGCTATCCTGCTGACCGACG
TACTTTTGCTGCTACAAGAAAAAGATCAGAAATACGTCTTTGCTTCTGTGGACTCAAAGCCACCCGTCATCTCGTTACAAAAGCTCATCG
TGAGGGAAGTGGCCAACGAGGAGAAAGCGATGTTTCTGATCAGCGCCTCCTTGCAAGGGCCGGAGATGTATGAAATCTACACGAGCTCCA
AAGAGGACAGGAACGCCTGGATGGCCCACATCCAAAGGGCTGTGGAGAGCTGCCCTGACGAGGAGGAGGGGCCCTTCAGCCTGCCCGAAG
AGGAAAGGAAGGTGGTCGAGGCCCGCGCCACGAGACTCCGGGACTTTCAAGAGCGGTTGAGCATGAAAGACCAGCTGATCGCACAGAGCC
TCCTAGAGAAACAGCAGATCTACCTGGAGATGGCCGAGATGGGCGGCCTCGAAGACCTGCCCCAGCCCCGAGGCCTATTCCGTGGAGGGG
ACCCATCCGAGACCCTGCAGGGGGAGCTAATTCTCAAGTCGGCCATGAGCGAGATCGAGGGCATCCAGAGCCTGATCTGCAGGCAGCTGG
GCAGCGCCAACGGCCAGGCGGAAGACGGAGGCAGCTCCACAGGCCCGCCCAGGAGGGCTGAGACCTTCGCGGGCTACGACTGCACAAACA
GCCCCACCAAGAATGGCAGTTTCAAGAAGAAAGTCAGCAGCACTGACCCCAGGCCCCGAGACTGGCGAGGCCCCCCAAACAGCCCGGACT
TGAAGCTCAGTGACAGTGACATTCCTGGGAGCTCTGAGGAATCGCCGCAGGTGGTGGAGGCGCCAGGCACGGAATCCGATCCCCGTCTGC
CCACCGTCCTGGAGTCGGAGCTTGTCCAGCGGATCCAGACACTGTCCCAGCTGCTCCTGAACCTTCAGGCGGTAATCGCCCACCAGGACA
GCTATGTGGAGACGCAGCGGGCTGCCATCCAGGAGCGGGAGAAGCAGTTCCGGCTGCAGTCGACGCGTGGGAACCTGCTGCTGGAGCAGG
AGCGGCAACGCAACTTCGAGAAGCAGCGGGAGGAGCGCGCGGCCCTGGAGAAGCTGCAGAGCCAGCTGCGGCACGAGCAGCAGCGCTGGG
AGCGCGAGCGCCAGTGGCAGCACCAGGAGCTGGAGCGTGCGGGCGCGCGGCTGCAGGAGCGCGAGGGCGAGGCGCGGCAGCTACGCGAGC
GGCTGGAGCAGGAGCGGGCCGAGCTGGAGCGCCAGCGCCAGGCCTACCAGCACGACCTGGAGCGGCTGCGCGAGGCCCAGCGTGCCGTGG
AGCGCGAGCGGGAGCGCCTGGAGCTGCTGCGCCGCCTCAAGAAGCAGAACACCGCGCCAGGCGCGCTGCCGCCCGACACACTGGCCGAGG
CCCAGCCCCCAAGCCACCCTCCCAGCTTCAACGGGGAAGGGCTGGAGGGCCCTCGTGTGAGCATGCTGCCATCCGGCGTGGGGCCAGAGT
ACGCAGAGCGCCCCGAGGTGGCTCGCCGGGACAGCGCCCCCACCGAGAACCGGCTGGCCAAGAGCGATGTGCCCATCCAGCTGCTCAGCG
CCACCAACCAGTTCCAGAGGCAGGCGGCCGTGCAGCAGCAGATCCCCACCAAGCTGGCGGCCTCCACCAAGGGTGGCAAGGACAAGGGCG
GCAAGAGCAGGGGCTCTCAGCGCTGGGAGAGCTCAGCGTCCTTCGACCTGAAGCAGCAGCTGCTGCTCAACAAGCTCATGGGGAAAGATG
AGAGCACCTCACGGAACCGCCGCTCGCTGAGCCCTATCCTGCCCGGCAGACACAGTCCTGCGCCCCCACCAGACCCTGGCTTCCCCGCCC
CGAGCCCACCGCCAGCTGACAGCCCCTCCGAGGGCTTCTCTCTCAAGGCCGGGGGCACAGCCCTCCTGCCCGGGCCCCCAGCTCCCTCGC
CACTGCCGGCCACACCACTCAGCGCCAAGGAGGACGCCAGCAAAGAAGACGTCATCTTCTTCTAAAAGGGCCGTGACTCAAGGAAAGTTT
TTAATGGAAAGTTGAGCCAGAACTAAACCAGGGAGCTGTCTGAAATCATAGCACCCCATCCGGGTGGCGGGGAGATCAACTCCGAGCTGT
TTTTCCGAGGCAGTGAGGAACGGTGCCGGCTCTGCACGGAGCTGAGGACAGGACAGACCTTGCTTTGAGAAGGAGCTGCCGGCCGGGGCC
ACGCTCCACAGCCGCCGCGCGACAGTGGAGCCAAGGGTTAGGGCACCAGGAGGGGCCAGGTGGCGTCGGCAGCATCTGTCCCCAGAATCA
GGCAGAATCCACTTCCCAAACAGAGCCCCACGCAGGTTCACCATGAACCTCAGGGTCAGGGAATGAGCCAGGCACGGGGGCATGGGCAGA
GAGGGCCACGGGGCAGGGCCCACTGAGGGAACATCAGTGGCCCTCCAGTCAGGTTCTGTGGGTTTGGAAGCCCATCGTGAAAGGGGCTGA
CCTTTGCCCCTTTTTACTTGGCATTGGTTTTGAAACCAGCTGTTTCCCAAACTCTGCTTCCCAAGGGCAACCGTTGCTGTTCACACGCTC
AGCCTGTCTGGGGGAGCGGGCCTCTAGCTTCAGCCAGGGCGGGTACACACCCTGGGCACAGGGTCCTCAGCCCCCGGGAAATGAGCTCCC
AGGGCTGGCGTCCCACCTTCCAGGTGGGGGCTGGCACATCACAGACTGTCGAGAGCGCCATGTCCCAGGGCATGCAGAGGATGCACCTAG
AGACGTTGCAGCAAGTGGACAAGTGGCCGCTGTGCGGGCCCCTCGCTTGTAGTGAGCTGTTGCAGCTTACGGTCCGTTCCCTGGAGGGGT
GGAGGAAGGAGGTGTTGGGCAGCATCAAAGGTGCTGGGACATCCCAGGGTGGTGAGATCCATCCACGATCCAGCTCCGGTGGAGAAAGGG
CCCATGTCAAGCCTTGTTCTGCACCCCAAGCATTGGTGGTAGGACTGGGTCCTGGCTGATCGTCCTTGTTCCCAGTGGGGTACATGTGAG
CCCCTGCCAGGGCCAAGTCCTTCTCCCGAACCCAGGGTCCTGGGAACTGCAGATCCCGGGGGGATTCAGCCCTTCTCCCACTGTGCTGGC
AGAGGCACTCCTGTGACGCTGAATACAGTGAACAGGGACATTCCCGCCACTCGGGGACAGATGGGCACAAGGGAGGGGAAACTCCATCAG
GAAGTGCTCCCCTGGGCAGAGGCGCCCACTGGGTGCTGTGGGCTCAGGAGGGGGCGGGGCAGGAGCTGGTGCCAACCGGGAACCAGAGCC
CCACAGCCATACAGCCCATTGGTGACAAGGTCCTGAGAACACAGTGGCCAGGTGTCCCCAGGCTCCTGGCCCCTCCGACGACCTCAACTC
TGCCCAGCCCGGTCCCTGGCCATCAGCGACGCTGTCCGCCCCCCGTCAGATCCCATGTGTGCCATGTTTATCATCAGTGTTTTGTATTTT
TGTACTGAGTATCGGAGCACTTTACAGAAGCTGACTGTACATTCCTGTTCTGTTGTGAAGAGAACATTCCCAGACCCTGGCACCCTCCTG
AGCCGGCGTGTGCCGGTCCAGCCCTCCGAGATGCCACAATTCCTTGGATGGGGGAGAAGTTCAAGGAATTTCTGCTCGGCCACGCGGTGG
GAACCCCGCGTCCCCGCCATGTGGCAGAGGGGTCTCAGTCGTGCTAGGCATCGGGCGGCAGCGCCGACAGCCCTTCCCTCGCCAGTGCCC
CTCGGCCACTCCTGGGTTGGAGCCCGATTTTATTTGTAAAGTTGACAGTCGAGCAAATGTTCCTATTTTCGTGGGATCTGCACACGTCTT
TGTCAGTTGTGGTCATGATCTTAGTCACCTGCTAATTATTTTTACAATGATTACAACATTTCCTCACTGCGGGATATTTCTGACCCGCTT

>62397_62397_1_PAK1-ARHGEF18_PAK1_chr11_77043775_ENST00000530617_ARHGEF18_chr19_7521213_ENST00000319670_length(amino acids)=658AA_BP=1
MAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEE
GPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQ
SLICRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDIPGSSEESPQVVEAPG
TESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQL
RHEQQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERERERLELLRRLKKQNTAPGAL
PPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAAST
KGGKDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDPGFPAPSPPPADSPSEGFSLKAGGTALL

--------------------------------------------------------------
>62397_62397_2_PAK1-ARHGEF18_PAK1_chr11_77043775_ENST00000530617_ARHGEF18_chr19_7521213_ENST00000359920_length(transcript)=5803nt_BP=1863nt
TGCTTTGCAGAAAAGGAGAAGCGCGCGGCTTCCTCCCGCCTCCTTCCCTCCTTTCTTCCCCCGCCCCTTCTGTTTCGCCAACCCCGACGC
GGCGCCTTCGCTGCCGCCCTGCGAGAGCGCGAGCGTGCTGCACCTCGGGAGCTGGCGGCTGAGCTGCCAGGAGCCCAGCCCAGCTGAATC
GAGCGGAGCCGGTGGAGCAGGGGCCTTGTGGGTACCCGGTTGGGCAGGGAGAGGTGCGGCTCTGCGACGGAAACAATCGCCAGAGATGCC
GGGGCTAGCCTTCCCCACCAGTAGCTGCTGCTGGTGGTGACAATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCG
ATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGATGCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAG
GAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCTGGAGATAAAACAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCT
CTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGATGCTGTCACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTG
CTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACA
TCCAACAGCCAGAAATACATGAGCTTTACAGATAAGTCAGCTGAGGATTACAATTCTTCTAATGCCTTGAATGTGAAGGCTGTGTCTGAG
ACTCCTGCAGTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGATGATGCTACCCCACCACCAGTGATTGCTCCACGCCCAGAGCAC
ACAAAATCTGTATACACACGGTCTGTGATTGAACCACTTCCTGTCACTCCAACTCGGGACGTGGCTACATCTCCCATTTCACCTACTGAA
AATAACACCACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAGAAGAAGAAGCCTAAAATGTCTGATGAGGAGATCTTGGAGAAA
TTACGAAGCATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGGTTTGAGAAGATTGGACAAGGTGCTTCAGGCACCGTGTACACA
GCAATGGATGTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAATCTTCAGCAGCAGCCCAAGAAAGAGCTGATTATTAATGAGATC
CTGGTCATGAGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGACAGTTACCTCGTGGGAGATGAGCTGTGGGTTGTTATGGAATAC
TTGGCTGGAGGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGATGAAGGCCAAATTGCAGCTGTGTGCCGTGAGTGTCTGCAGGCT
CTGGAGTTCTTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGTGACAATATTCTGTTGGGAATGGATGGCTCTGTCAAGCTAACT
GACTTTGGATTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGCACCATGGTAGGAACCCCATACTGGATGGCACCAGAGGTTGTG
ACACGAAAGGCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATCATGGCCATCGAAATGATTGAAGGGGAGCCTCCATACCTCAAT
GAAAACCCTCTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCAGAACTTCAGAACCCAGAGAAGCTGTCAGCTATCTTCCGGGAC
TTTCTGAACCGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCTAAAGAGCTGCTACAGATATCCTGGCTATCCTGCTGACCGACG
TACTTTTGCTGCTACAAGAAAAAGATCAGAAATACGTCTTTGCTTCTGTGGACTCAAAGCCACCCGTCATCTCGTTACAAAAGCTCATCG
TGAGGGAAGTGGCCAACGAGGAGAAAGCGATGTTTCTGATCAGCGCCTCCTTGCAAGGGCCGGAGATGTATGAAATCTACACGAGCTCCA
AAGAGGACAGGAACGCCTGGATGGCCCACATCCAAAGGGCTGTGGAGAGCTGCCCTGACGAGGAGGAGGGGCCCTTCAGCCTGCCCGAAG
AGGAAAGGAAGGTGGTCGAGGCCCGCGCCACGAGACTCCGGGACTTTCAAGAGCGGTTGAGCATGAAAGACCAGCTGATCGCACAGAGCC
TCCTAGAGAAACAGCAGATCTACCTGGAGATGGCCGAGATGGGCGGCCTCGAAGACCTGCCCCAGCCCCGAGGCCTATTCCGTGGAGGGG
ACCCATCCGAGACCCTGCAGGGGGAGCTAATTCTCAAGTCGGCCATGAGCGAGATCGAGGGCATCCAGAGCCTGATCTGCAGGCAGCTGG
GCAGCGCCAACGGCCAGGCGGAAGACGGAGGCAGCTCCACAGGCCCGCCCAGGAGGGCTGAGACCTTCGCGGGCTACGACTGCACAAACA
GCCCCACCAAGAATGGCAGTTTCAAGAAGAAAGTCAGCAGCACTGACCCCAGGCCCCGAGACTGGCGAGGCCCCCCAAACAGCCCGGACT
TGAAGCTCAGTGACAGTGACATTCCTGGGAGCTCTGAGGAATCGCCGCAGGTGGTGGAGGCGCCAGGCACGGAATCCGATCCCCGTCTGC
CCACCGTCCTGGAGTCGGAGCTTGTCCAGCGGATCCAGACACTGTCCCAGCTGCTCCTGAACCTTCAGGCGGTAATCGCCCACCAGGACA
GCTATGTGGAGACGCAGCGGGCTGCCATCCAGGAGCGGGAGAAGCAGTTCCGGCTGCAGTCGACGCGTGGGAACCTGCTGCTGGAGCAGG
AGCGGCAACGCAACTTCGAGAAGCAGCGGGAGGAGCGCGCGGCCCTGGAGAAGCTGCAGAGCCAGCTGCGGCACGAGCAGCAGCGCTGGG
AGCGCGAGCGCCAGTGGCAGCACCAGGAGCTGGAGCGTGCGGGCGCGCGGCTGCAGGAGCGCGAGGGCGAGGCGCGGCAGCTACGCGAGC
GGCTGGAGCAGGAGCGGGCCGAGCTGGAGCGCCAGCGCCAGGCCTACCAGCACGACCTGGAGCGGCTGCGCGAGGCCCAGCGTGCCGTGG
AGCGCGAGCGGGAGCGCCTGGAGCTGCTGCGCCGCCTCAAGAAGCAGAACACCGCGCCAGGCGCGCTGCCGCCCGACACACTGGCCGAGG
CCCAGCCCCCAAGCCACCCTCCCAGCTTCAACGGGGAAGGGCTGGAGGGCCCTCGTGTGAGCATGCTGCCATCCGGCGTGGGGCCAGAGT
ACGCAGAGCGCCCCGAGGTGGCTCGCCGGGACAGCGCCCCCACCGAGAACCGGCTGGCCAAGAGCGATGTGCCCATCCAGCTGCTCAGCG
CCACCAACCAGTTCCAGAGGCAGGCGGCCGTGCAGCAGCAGATCCCCACCAAGCTGGCGGCCTCCACCAAGGGTGGCAAGGACAAGGGCG
GCAAGAGCAGGGGCTCTCAGCGCTGGGAGAGCTCAGCGTCCTTCGACCTGAAGCAGCAGCTGCTGCTCAACAAGCTCATGGGGAAAGATG
AGAGCACCTCACGGAACCGCCGCTCGCTGAGCCCTATCCTGCCCGGCAGACACAGTCCTGCGCCCCCACCAGACCCTGGCTTCCCCGCCC
CGAGCCCACCGCCAGCTGACAGCCCCTCCGAGGGCTTCTCTCTCAAGGCCGGGGGCACAGCCCTCCTGCCCGGGCCCCCAGCTCCCTCGC
CACTGCCGGCCACACCACTCAGCGCCAAGGAGGACGCCAGCAAAGAAGACGTCATCTTCTTCTAAAAGGGCCGTGACTCAAGGAAAGTTT
TTAATGGAAAGTTGAGCCAGAACTAAACCAGGGAGCTGTCTGAAATCATAGCACCCCATCCGGGTGGCGGGGAGATCAACTCCGAGCTGT
TTTTCCGAGGCAGTGAGGAACGGTGCCGGCTCTGCACGGAGCTGAGGACAGGACAGACCTTGCTTTGAGAAGGAGCTGCCGGCCGGGGCC
ACGCTCCACAGCCGCCGCGCGACAGTGGAGCCAAGGGTTAGGGCACCAGGAGGGGCCAGGTGGCGTCGGCAGCATCTGTCCCCAGAATCA
GGCAGAATCCACTTCCCAAACAGAGCCCCACGCAGGTTCACCATGAACCTCAGGGTCAGGGAATGAGCCAGGCACGGGGGCATGGGCAGA
GAGGGCCACGGGGCAGGGCCCACTGAGGGAACATCAGTGGCCCTCCAGTCAGGTTCTGTGGGTTTGGAAGCCCATCGTGAAAGGGGCTGA
CCTTTGCCCCTTTTTACTTGGCATTGGTTTTGAAACCAGCTGTTTCCCAAACTCTGCTTCCCAAGGGCAACCGTTGCTGTTCACACGCTC
AGCCTGTCTGGGGGAGCGGGCCTCTAGCTTCAGCCAGGGCGGGTACACACCCTGGGCACAGGGTCCTCAGCCCCCGGGAAATGAGCTCCC
AGGGCTGGCGTCCCACCTTCCAGGTGGGGGCTGGCACATCACAGACTGTCGAGAGCGCCATGTCCCAGGGCATGCAGAGGATGCACCTAG
AGACGTTGCAGCAAGTGGACAAGTGGCCGCTGTGCGGGCCCCTCGCTTGTAGTGAGCTGTTGCAGCTTACGGTCCGTTCCCTGGAGGGGT
GGAGGAAGGAGGTGTTGGGCAGCATCAAAGGTGCTGGGACATCCCAGGGTGGTGAGATCCATCCACGATCCAGCTCCGGTGGAGAAAGGG
CCCATGTCAAGCCTTGTTCTGCACCCCAAGCATTGGTGGTAGGACTGGGTCCTGGCTGATCGTCCTTGTTCCCAGTGGGGTACATGTGAG
CCCCTGCCAGGGCCAAGTCCTTCTCCCGAACCCAGGGTCCTGGGAACTGCAGATCCCGGGGGGATTCAGCCCTTCTCCCACTGTGCTGGC
AGAGGCACTCCTGTGACGCTGAATACAGTGAACAGGGACATTCCCGCCACTCGGGGACAGATGGGCACAAGGGAGGGGAAACTCCATCAG
GAAGTGCTCCCCTGGGCAGAGGCGCCCACTGGGTGCTGTGGGCTCAGGAGGGGGCGGGGCAGGAGCTGGTGCCAACCGGGAACCAGAGCC
CCACAGCCATACAGCCCATTGGTGACAAGGTCCTGAGAACACAGTGGCCAGGTGTCCCCAGGCTCCTGGCCCCTCCGACGACCTCAACTC
TGCCCAGCCCGGTCCCTGGCCATCAGCGACGCTGTCCGCCCCCCGTCAGATCCCATGTGTGCCATGTTTATCATCAGTGTTTTGTATTTT
TGTACTGAGTATCGGAGCACTTTACAGAAGCTGACTGTACATTCCTGTTCTGTTGTGAAGAGAACATTCCCAGACCCTGGCACCCTCCTG
AGCCGGCGTGTGCCGGTCCAGCCCTCCGAGATGCCACAATTCCTTGGATGGGGGAGAAGTTCAAGGAATTTCTGCTCGGCCACGCGGTGG
GAACCCCGCGTCCCCGCCATGTGGCAGAGGGGTCTCAGTCGTGCTAGGCATCGGGCGGCAGCGCCGACAGCCCTTCCCTCGCCAGTGCCC
CTCGGCCACTCCTGGGTTGGAGCCCGATTTTATTTGTAAAGTTGACAGTCGAGCAAATGTTCCTATTTTCGTGGGATCTGCACACGTCTT
TGTCAGTTGTGGTCATGATCTTAGTCACCTGCTAATTATTTTTACAATGATTACAACATTTCCTCACTGCGGGATATTTCTGACCCGCTT

>62397_62397_2_PAK1-ARHGEF18_PAK1_chr11_77043775_ENST00000530617_ARHGEF18_chr19_7521213_ENST00000359920_length(amino acids)=658AA_BP=1
MAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEE
GPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQ
SLICRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDIPGSSEESPQVVEAPG
TESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQL
RHEQQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERERERLELLRRLKKQNTAPGAL
PPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAAST
KGGKDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDPGFPAPSPPPADSPSEGFSLKAGGTALL

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Fusion Gene PPI Analysis for PAK1-ARHGEF18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgenePAK1chr11:77043775chr19:7521213ENST00000278568-1416132_270517.0554.0CRIPAK
HgenePAK1chr11:77043775chr19:7521213ENST00000356341-1415132_270517.0546.0CRIPAK


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PAK1-ARHGEF18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PAK1-ARHGEF18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource