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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PANK4-SKI (FusionGDB2 ID:62562)

Fusion Gene Summary for PANK4-SKI

Fusion gene summary

Fusion gene information	Fusion gene name: PANK4-SKI
	Fusion gene ID: 62562
		Hgene	Tgene
	Gene symbol	PANK4	SKI
	Gene ID	55229	6497
	Gene name	pantothenate kinase 4 (inactive)	SKI proto-oncogene
	Synonyms	-	SGS\|SKV
	Cytomap	1p36.32	1p36.33-p36.32
	Type of gene	protein-coding	protein-coding
	Description	4'-phosphopantetheine phosphataseinactive pantothenic acid kinase 4pantothenic acid kinase 4	ski oncogeneproto-oncogene c-Skiski oncoproteinv-ski avian sarcoma viral oncogene homolog
	Modification date	20200315	20200329
	UniProtAcc	.	SKIDA1,C10orf140
	Ensembl transtripts involved in fusion gene	ENST00000378466, ENST00000435556, ENST00000491212,	ENST00000478223, ENST00000378536,
Fusion gene scores	* DoF score	5 X 8 X 6=240	17 X 5 X 6=510
	# samples	7	17
	** MAII score	log2(7/240*10)=-1.77760757866355 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/510*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PANK4 [Title/Abstract] AND SKI [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PANK4(2457903)-SKI(2234417), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SKI	GO:0000122	negative regulation of transcription by RNA polymerase II	17469184
Tgene	SKI	GO:0008285	negative regulation of cell proliferation	11430826
Tgene	SKI	GO:0014902	myotube differentiation	19008232
Tgene	SKI	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	17469184
Tgene	SKI	GO:0030514	negative regulation of BMP signaling pathway	14699069
Tgene	SKI	GO:0032926	negative regulation of activin receptor signaling pathway	14699069
Tgene	SKI	GO:0043388	positive regulation of DNA binding	15107821
Tgene	SKI	GO:0045668	negative regulation of osteoblast differentiation	14699069
Tgene	SKI	GO:0060395	SMAD protein signal transduction	12874272

Fusion gene breakpoints across PANK4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SKI (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-A486-01A	PANK4	chr1	2457903	-	SKI	chr1	2234417	+

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Fusion Gene ORF analysis for PANK4-SKI

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000378466	ENST00000478223	PANK4	chr1	2457903	-	SKI	chr1	2234417	+
5CDS-3UTR	ENST00000435556	ENST00000478223	PANK4	chr1	2457903	-	SKI	chr1	2234417	+
In-frame	ENST00000378466	ENST00000378536	PANK4	chr1	2457903	-	SKI	chr1	2234417	+
In-frame	ENST00000435556	ENST00000378536	PANK4	chr1	2457903	-	SKI	chr1	2234417	+
intron-3CDS	ENST00000491212	ENST00000378536	PANK4	chr1	2457903	-	SKI	chr1	2234417	+
intron-3UTR	ENST00000491212	ENST00000478223	PANK4	chr1	2457903	-	SKI	chr1	2234417	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000378466

PANK4

chr1

2457903

ENST00000378536

SKI

chr1

2234417

4709

137

1545

388

385

ENST00000435556

PANK4

chr1

2457903

ENST00000378536

SKI

chr1

2234417

4705

133

1541

384

385

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000378466	ENST00000378536	PANK4	chr1	2457903	-	SKI	chr1	2234417	+	0.8527394	0.14726065
ENST00000435556	ENST00000378536	PANK4	chr1	2457903	-	SKI	chr1	2234417	+	0.85332346	0.14667657

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Fusion Genomic Features for PANK4-SKI

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PANK4	chr1	2457902	-	SKI	chr1	2234416	+	4.20E-07	0.9999995
PANK4	chr1	2457902	-	SKI	chr1	2234416	+	4.20E-07	0.9999995

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PANK4-SKI

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:2457903/chr1:2234417)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	SKI SKIDA1,C10orf140
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	908

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SKI

chr1:2457903

chr1:2234417

ENST00000378536

536_710

323

729.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PANK4

chr1:2457903

chr1:2234417

ENST00000378466

724_728

774.0

Motif

Subfamily II EGMGR motif

Hgene

PANK4

chr1:2457903

chr1:2234417

ENST00000378466

2_402

774.0

Region

Pantothenate kinase

Hgene

PANK4

chr1:2457903

chr1:2234417

ENST00000378466

403_773

774.0

Region

4'-phosphopantetheine phosphatase

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Fusion Gene Sequence for PANK4-SKI

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>62562_62562_1_PANK4-SKI_PANK4_chr1_2457903_ENST00000378466_SKI_chr1_2234417_ENST00000378536_length(transcript)=4709nt_BP=137nt
GGGCACTTTCAAAATGGCGGAGTGTGGAGCGAGCGGCAGCGGGAGCAGCGGGGACAGTCTGGACAAGAGCATCACGCTGCCCCCCGACGA
GATCTTCCGCAACCTGGAGAACGCCAAGCGCTTCGCCATCGACATAGGTCTCCTCTGAGCCTCCGGCCTCCATAAGACCCAAAACAGATG
ACACCTCTTCCCAGTCCCCCGCGCCTTCCGAAAAGGACAAGCCGTCCAGCTGGCTGCGGACCTTGGCCGGCTCTTCCAATAAGAGCCTGG
GCTGTGTTCACCCTCGCCAGCGCCTCTCTGCTTTCCGACCCTGGTCCCCCGCAGTGTCAGCGAGTGAGAAAGAGCTCTCCCCACACCTCC
CGGCCCTCATCCGAGACAGCTTCTACTCCTACAAGAGCTTTGAGACAGCCGTGGCGCCCAACGTGGCCCTCGCACCGCCGGCCCAGCAGA
AGGTTGTGAGCAGCCCTCCGTGTGCCGCCGCCGTCTCCCGGGCCCCCGAGCCTCTCGCCACTTGCACCCAGCCTCGGAAGCGGAAGCTGA
CTGTGGACACCCCAGGAGCCCCAGAGACGCTGGCGCCCGTGGCTGCCCCAGAGGAGGACAAGGACTCGGAGGCGGAGGTGGAAGTTGAAA
GCAGGGAGGAATTCACCTCCTCCTTGTCCTCGCTCTCTTCCCCGTCCTTTACCTCATCCAGCTCCGCCAAGGACCTGGGCTCCCCGGGTG
CGCGTGCCCTGCCCTCGGCCGTCCCTGATGCTGCGGCCCCTGCCGACGCCCCCAGTGGGCTGGAGGCGGAGCTGGAGCACCTGCGGCAGG
CACTGGAGGGCGGCCTGGACACCAAGGAAGCCAAAGAGAAGTTCCTGCATGAGGTGGTCAAGATGCGCGTGAAGCAGGAGGAGAAGCTCA
GCGCAGCCCTGCAGGCCAAGCGCAGCCTCCACCAGGAGCTGGAGTTCCTACGCGTGGCCAAGAAGGAGAAGCTGCGGGAGGCCACGGAGG
CCAAGCGTAACCTGCGGAAGGAGATCGAGCGTCTCCGCGCCGAGAACGAGAAGAAGATGAAAGAGGCCAACGAGTCACGGCTGCGCCTGA
AGCGGGAGCTGGAGCAGGCGCGGCAGGCCCGGGTGTGCGACAAGGGCTGCGAGGCGGGCCGCCTGCGCGCCAAGTACTCGGCCCAGATCG
AAGACCTGCAGGTGAAGCTGCAGCACGCGGAGGCGGACCGGGAGCAGCTGCGGGCCGACCTGCTGCGGGAGCGCGAGGCCCGGGAGCACC
TGGAGAAGGTGGTGAAGGAGCTGCAGGAACAGCTGTGGCCGCGGGCCCGCCCCGAGGCTGCGGGCAGCGAGGGCGCTGCGGAGCTGGAGC
CGTAGATTCCGTGCCTGCCGCCGCAGCGCCGCCGACAACGCGGGTGCAGGGGGGCGCGGCTGGGCGGTGCAGCTCCGCCCGGCTCCGCCC
CTGCAGCCCACACAGCACAACGTCTTACCGTGCCTATTACCAAGCGAGTGTTTGTAACCATGTAGTTTTGGAACCCACTGCAAAATTTTC
TACTGGCCAAGTTCAAGTGAGTAAGCCGCGTCCCCCAACTACAGCTGGAGACGGGGCCAGCTCGGCGGCCTGCTGGTCCTCTGCTTGCTG
GAACATTCTAACATTTACACTTTTGTTATAAGCTATTTAAAACCAGTAAGGAGACTTGAAATTCAGAAAATCAACACATTTTTAAATGAC
TAACTTCTAAAAGCCCCAACACATGACGCCATCTGAAGACCCGCAACGGAGTGGGGGTGGCGGCCGCCCCACCCTCCCCACCCGGGGAAG
CCATCACAGCTCATCTGCCCGCGGCTGCGTGAGGACAGCAGGGGTTTTTCTTCAGAGTCTATTTTTTCAGCGACAAGGACCCAGGTCTTC
CTGCTGCTGCCAGGGAGAGCAGGGACAGTGCCGCGTGCGAGATGAGCTCGAACACTGCCCGCCTTACTGCCGCCTACCCCGCCCGCCACG
CCGCCGTCGATGCCAGCGCTGTCCCCACGGGTACCAGGAAGTGCAGAGCCGCACAGGAGCTGCCCCGGAGCTGAGGGGACGGTCTTCGGC
TCCTCTGCACCCCGTGATTCTGCCCACGCTCCTCCACCACGAGGCACTGACCTGCGTCGGGTGGTGACCGTGGCTGGCGGTCACGCCCTC
AGCCCCTCCGGGCACACGTGCCGCCTGACCGGGCGACCCTTTTCAGTTCGGCAAACGTCGCTCCCTTCATTTTGGGACTGAGGCTGCAGC
ATTGGAACAAAAGAGCATTATTTCAATTTTTCTTTCTTTTTTTTTGTTCGTTCATTTAAACGTATATTTAGAACTGCACTTTGTCCACAA
CCTTCCCTTCTCTTTCTATTCCCCAGTGAACTGAGGTTTTTACCGATTTATAGAGCAGTCAAATCCGAAGTGCTCGAGTGCTTAGAAACC
CCCTCTGGTGCTTGGTTGAACAAGGGAATCACAAGAAAACGAAAATGCAAAAACTGAACTTCGGGGGTCGTTCTGTGCCTTCCAGCATCT
TGTACAGCAAATCCTGACTCGTGTCTTTTTACCCCCAAGATATCTGTCTTCAGTAGCGACTGAATCTGCCACTCTCAGAATAAGTTCCTT
GCATTTATTCCAAATAATCTCGTTTACTCTCACCTGTTTATGCAAATTGTATAAGGTTTCTTATGCCCAAGCTTGAAAAATGATTTCCCA
GTAGACAAGAGGCGGCTACCTATCCTACAGTTACGGTATTTATTTACATAAGAAGATCTTACAGGAGTTCTTTGCTTGAATCCGTTCTAA
CACCCGCGGCAGCTGCACGCGCTCACAGAAGGTGGAGGTTACTTGCCCAGGTACAGACGACCTCGGGGCAGTGACGAGCAAAGACCAGAG
ACTGCTGAGCCCTCGCATCTGGGTGGCGGAATTGCCTGCGGGGTTTTGCCCTTGGTTTACTGAGGGGGGTCTTGGTTGCTGCTGAAGCCC
CCCACCCCTTCTAAAGTGCAATGCAAAAGGGACATCATGTATATGCAGCGTTTGTTTGGAATTTTCTTTGCTTTTGTTTTCTTTGCGGTT
GTTCTGTGTGCATGGATTCCACACCTCTGCCGTAGGTAGATCCGTCAGCGGGCATTATTACCGTGTCTTGTAAAGGGTCGGTTTTGTTAT
GCAACATGCAGAATGCTGTTTTTAGCCTTGTTTTACCAGAGTTGTTTTTTTTTTCAGTTATTTCTTCAAGGGAAACTAAATGATTTAGTT
GGAGCAAAGCTTTAAGTGTGTTGGCGTGCTTCTGTGTGGCTGTCCTGTGTCGCCAGGTCGAAGATCACAGTGAGGTAGAGGCCCTGCCCC
ATCCCCAGGGCCGCCAGGCTTGCTCCGTTTGCTTTGAGTTTTTAGACCCCAGAGGGAGATGAGCTTTTCCAAGCTGTGTCTGGGCCAGAG
CCTCTCCTTGCCCTTGCTCCATCCCGACGGTCACCGTTGGGTCCACGCCTCCACCGCCCCATCTTGCCCCAAACGGAAAGCGCTGTATCT
GCAGTGGCAGCCCTTCCCCACTTCGGCTCTGGGAGGGTCCAGCCAGTGTCACCTGGGCCCACCCTTTCCTGCAGCTGCCAGGCCCGTGCG
GTCAGTGGGACCCGGACGTGGGCAGGCGAGCTCGGGACCCTCCCAGGCAGTTCCCACAGCTCTTGCCTCGGCTCACCAGGGTCACTTCCA
CTGTCAGGGGCCTGAGGGGGCAGCTGTGGCTGCAGGGCTGCTCTGGACTGAGGGGTCCCAGGCCCCGAGGGGTGCACGCCTGGCTCCCCT
TGGCACAGGTGCGAGTCCGTTTCTTTTCAGCAGAAGGGGGAAGAGGTGTCCGCTGTGTGGGCTGCTGACTCCTCTGTGTGTGAGGCCCTT
CATCTAAGTGATTGTGTATTCAGTTTAATTCTCATTATATTTCTATACTGAAAGAAGATTTTTAACGAAGGGAAAAACAACAGCAATAAC
ATTCATATCTCTGGAGCAGCTAACTCATACACGTAATGTCTGCTTTTCGTACAGAACTAGCCAATGTAAAAACAGTTCACCTGTAAATAC
TTTTTCCTTTTTCACCGTTGTATTATACATGTATATGCTGGGTCCTTTTTCAGAAACTCTTTTCTTACCTGAGAGTTGTCTTGTTTTCTG
GGCTGTTTTTAACTGAGGAAAAAAAAAATGCTTTCCTGCCGGGGGGCAGGGGAGACGGAGAAACCCATGTGCGTTTCCCATGTGACCCCC
TCCTCCCTGTGGGTCTGAGCCCCGGCCCCCCCCACCTCCTCCTCCCTGTGGGTCCGAACCCCGGCCCCCCCACCCCCTCCTCCCTGTGGG
TCCGAACCCCGGCCCCCCCACCCCCTCCTCCCTGTGGGTCCGATCCCCGGCCCCCCCCACCCCCTCCTCCCTGTGGGTCCGAACCCCGGC
CCCCCCCCCACCCCCTCCTCCCTGTGGGTCCGAACCCCGGCCCCCCCACCCCTCCCTCAGCCCACCAGGGTCCAGGGAGATGTTCGTTCT
CGCTTTAAGTCAGGAGTCACAAATGACTTTTTTTTTTCAATTAAGGAAAAAGCTCCATCTCTACCTTTAACATCACCCAGACCCCCGCCC
CTGCCCGTGCCCCACGCTGCTGCTAACGACAGTATGATGCTTACTCTGCTACTCGGAAACTATTTTTATGTAATTAATGTATGCTTTCTT

>62562_62562_1_PANK4-SKI_PANK4_chr1_2457903_ENST00000378466_SKI_chr1_2234417_ENST00000378536_length(amino acids)=385AA_BP=
MNLASRKFCSGFQNYMVTNTRLVIGTVRRCAVWAAGAEPGGAAPPSRAPLHPRCRRRCGGRHGIYGSSSAAPSLPAASGRARGHSCSCSS
FTTFSRCSRASRSRSRSARSCSRSASACCSFTCRSSIWAEYLARRRPASQPLSHTRACRACSSSRFRRSRDSLASFIFFSFSARRRSISF
RRLRLASVASRSFSFLATRRNSSSWWRLRLACRAALSFSSCFTRILTTSCRNFSLASLVSRPPSSACRRCSSSASSPLGASAGAAASGTA
EGRARAPGEPRSLAELDEVKDGEESEDKEEVNSSLLSTSTSASESLSSSGAATGASVSGAPGVSTVSFRFRGWVQVARGSGARETAAAHG

--------------------------------------------------------------
>62562_62562_2_PANK4-SKI_PANK4_chr1_2457903_ENST00000435556_SKI_chr1_2234417_ENST00000378536_length(transcript)=4705nt_BP=133nt
ACTTTCAAAATGGCGGAGTGTGGAGCGAGCGGCAGCGGGAGCAGCGGGGACAGTCTGGACAAGAGCATCACGCTGCCCCCCGACGAGATC
TTCCGCAACCTGGAGAACGCCAAGCGCTTCGCCATCGACATAGGTCTCCTCTGAGCCTCCGGCCTCCATAAGACCCAAAACAGATGACAC
CTCTTCCCAGTCCCCCGCGCCTTCCGAAAAGGACAAGCCGTCCAGCTGGCTGCGGACCTTGGCCGGCTCTTCCAATAAGAGCCTGGGCTG
TGTTCACCCTCGCCAGCGCCTCTCTGCTTTCCGACCCTGGTCCCCCGCAGTGTCAGCGAGTGAGAAAGAGCTCTCCCCACACCTCCCGGC
CCTCATCCGAGACAGCTTCTACTCCTACAAGAGCTTTGAGACAGCCGTGGCGCCCAACGTGGCCCTCGCACCGCCGGCCCAGCAGAAGGT
TGTGAGCAGCCCTCCGTGTGCCGCCGCCGTCTCCCGGGCCCCCGAGCCTCTCGCCACTTGCACCCAGCCTCGGAAGCGGAAGCTGACTGT
GGACACCCCAGGAGCCCCAGAGACGCTGGCGCCCGTGGCTGCCCCAGAGGAGGACAAGGACTCGGAGGCGGAGGTGGAAGTTGAAAGCAG
GGAGGAATTCACCTCCTCCTTGTCCTCGCTCTCTTCCCCGTCCTTTACCTCATCCAGCTCCGCCAAGGACCTGGGCTCCCCGGGTGCGCG
TGCCCTGCCCTCGGCCGTCCCTGATGCTGCGGCCCCTGCCGACGCCCCCAGTGGGCTGGAGGCGGAGCTGGAGCACCTGCGGCAGGCACT
GGAGGGCGGCCTGGACACCAAGGAAGCCAAAGAGAAGTTCCTGCATGAGGTGGTCAAGATGCGCGTGAAGCAGGAGGAGAAGCTCAGCGC
AGCCCTGCAGGCCAAGCGCAGCCTCCACCAGGAGCTGGAGTTCCTACGCGTGGCCAAGAAGGAGAAGCTGCGGGAGGCCACGGAGGCCAA
GCGTAACCTGCGGAAGGAGATCGAGCGTCTCCGCGCCGAGAACGAGAAGAAGATGAAAGAGGCCAACGAGTCACGGCTGCGCCTGAAGCG
GGAGCTGGAGCAGGCGCGGCAGGCCCGGGTGTGCGACAAGGGCTGCGAGGCGGGCCGCCTGCGCGCCAAGTACTCGGCCCAGATCGAAGA
CCTGCAGGTGAAGCTGCAGCACGCGGAGGCGGACCGGGAGCAGCTGCGGGCCGACCTGCTGCGGGAGCGCGAGGCCCGGGAGCACCTGGA
GAAGGTGGTGAAGGAGCTGCAGGAACAGCTGTGGCCGCGGGCCCGCCCCGAGGCTGCGGGCAGCGAGGGCGCTGCGGAGCTGGAGCCGTA
GATTCCGTGCCTGCCGCCGCAGCGCCGCCGACAACGCGGGTGCAGGGGGGCGCGGCTGGGCGGTGCAGCTCCGCCCGGCTCCGCCCCTGC
AGCCCACACAGCACAACGTCTTACCGTGCCTATTACCAAGCGAGTGTTTGTAACCATGTAGTTTTGGAACCCACTGCAAAATTTTCTACT
GGCCAAGTTCAAGTGAGTAAGCCGCGTCCCCCAACTACAGCTGGAGACGGGGCCAGCTCGGCGGCCTGCTGGTCCTCTGCTTGCTGGAAC
ATTCTAACATTTACACTTTTGTTATAAGCTATTTAAAACCAGTAAGGAGACTTGAAATTCAGAAAATCAACACATTTTTAAATGACTAAC
TTCTAAAAGCCCCAACACATGACGCCATCTGAAGACCCGCAACGGAGTGGGGGTGGCGGCCGCCCCACCCTCCCCACCCGGGGAAGCCAT
CACAGCTCATCTGCCCGCGGCTGCGTGAGGACAGCAGGGGTTTTTCTTCAGAGTCTATTTTTTCAGCGACAAGGACCCAGGTCTTCCTGC
TGCTGCCAGGGAGAGCAGGGACAGTGCCGCGTGCGAGATGAGCTCGAACACTGCCCGCCTTACTGCCGCCTACCCCGCCCGCCACGCCGC
CGTCGATGCCAGCGCTGTCCCCACGGGTACCAGGAAGTGCAGAGCCGCACAGGAGCTGCCCCGGAGCTGAGGGGACGGTCTTCGGCTCCT
CTGCACCCCGTGATTCTGCCCACGCTCCTCCACCACGAGGCACTGACCTGCGTCGGGTGGTGACCGTGGCTGGCGGTCACGCCCTCAGCC
CCTCCGGGCACACGTGCCGCCTGACCGGGCGACCCTTTTCAGTTCGGCAAACGTCGCTCCCTTCATTTTGGGACTGAGGCTGCAGCATTG
GAACAAAAGAGCATTATTTCAATTTTTCTTTCTTTTTTTTTGTTCGTTCATTTAAACGTATATTTAGAACTGCACTTTGTCCACAACCTT
CCCTTCTCTTTCTATTCCCCAGTGAACTGAGGTTTTTACCGATTTATAGAGCAGTCAAATCCGAAGTGCTCGAGTGCTTAGAAACCCCCT
CTGGTGCTTGGTTGAACAAGGGAATCACAAGAAAACGAAAATGCAAAAACTGAACTTCGGGGGTCGTTCTGTGCCTTCCAGCATCTTGTA
CAGCAAATCCTGACTCGTGTCTTTTTACCCCCAAGATATCTGTCTTCAGTAGCGACTGAATCTGCCACTCTCAGAATAAGTTCCTTGCAT
TTATTCCAAATAATCTCGTTTACTCTCACCTGTTTATGCAAATTGTATAAGGTTTCTTATGCCCAAGCTTGAAAAATGATTTCCCAGTAG
ACAAGAGGCGGCTACCTATCCTACAGTTACGGTATTTATTTACATAAGAAGATCTTACAGGAGTTCTTTGCTTGAATCCGTTCTAACACC
CGCGGCAGCTGCACGCGCTCACAGAAGGTGGAGGTTACTTGCCCAGGTACAGACGACCTCGGGGCAGTGACGAGCAAAGACCAGAGACTG
CTGAGCCCTCGCATCTGGGTGGCGGAATTGCCTGCGGGGTTTTGCCCTTGGTTTACTGAGGGGGGTCTTGGTTGCTGCTGAAGCCCCCCA
CCCCTTCTAAAGTGCAATGCAAAAGGGACATCATGTATATGCAGCGTTTGTTTGGAATTTTCTTTGCTTTTGTTTTCTTTGCGGTTGTTC
TGTGTGCATGGATTCCACACCTCTGCCGTAGGTAGATCCGTCAGCGGGCATTATTACCGTGTCTTGTAAAGGGTCGGTTTTGTTATGCAA
CATGCAGAATGCTGTTTTTAGCCTTGTTTTACCAGAGTTGTTTTTTTTTTCAGTTATTTCTTCAAGGGAAACTAAATGATTTAGTTGGAG
CAAAGCTTTAAGTGTGTTGGCGTGCTTCTGTGTGGCTGTCCTGTGTCGCCAGGTCGAAGATCACAGTGAGGTAGAGGCCCTGCCCCATCC
CCAGGGCCGCCAGGCTTGCTCCGTTTGCTTTGAGTTTTTAGACCCCAGAGGGAGATGAGCTTTTCCAAGCTGTGTCTGGGCCAGAGCCTC
TCCTTGCCCTTGCTCCATCCCGACGGTCACCGTTGGGTCCACGCCTCCACCGCCCCATCTTGCCCCAAACGGAAAGCGCTGTATCTGCAG
TGGCAGCCCTTCCCCACTTCGGCTCTGGGAGGGTCCAGCCAGTGTCACCTGGGCCCACCCTTTCCTGCAGCTGCCAGGCCCGTGCGGTCA
GTGGGACCCGGACGTGGGCAGGCGAGCTCGGGACCCTCCCAGGCAGTTCCCACAGCTCTTGCCTCGGCTCACCAGGGTCACTTCCACTGT
CAGGGGCCTGAGGGGGCAGCTGTGGCTGCAGGGCTGCTCTGGACTGAGGGGTCCCAGGCCCCGAGGGGTGCACGCCTGGCTCCCCTTGGC
ACAGGTGCGAGTCCGTTTCTTTTCAGCAGAAGGGGGAAGAGGTGTCCGCTGTGTGGGCTGCTGACTCCTCTGTGTGTGAGGCCCTTCATC
TAAGTGATTGTGTATTCAGTTTAATTCTCATTATATTTCTATACTGAAAGAAGATTTTTAACGAAGGGAAAAACAACAGCAATAACATTC
ATATCTCTGGAGCAGCTAACTCATACACGTAATGTCTGCTTTTCGTACAGAACTAGCCAATGTAAAAACAGTTCACCTGTAAATACTTTT
TCCTTTTTCACCGTTGTATTATACATGTATATGCTGGGTCCTTTTTCAGAAACTCTTTTCTTACCTGAGAGTTGTCTTGTTTTCTGGGCT
GTTTTTAACTGAGGAAAAAAAAAATGCTTTCCTGCCGGGGGGCAGGGGAGACGGAGAAACCCATGTGCGTTTCCCATGTGACCCCCTCCT
CCCTGTGGGTCTGAGCCCCGGCCCCCCCCACCTCCTCCTCCCTGTGGGTCCGAACCCCGGCCCCCCCACCCCCTCCTCCCTGTGGGTCCG
AACCCCGGCCCCCCCACCCCCTCCTCCCTGTGGGTCCGATCCCCGGCCCCCCCCACCCCCTCCTCCCTGTGGGTCCGAACCCCGGCCCCC
CCCCCACCCCCTCCTCCCTGTGGGTCCGAACCCCGGCCCCCCCACCCCTCCCTCAGCCCACCAGGGTCCAGGGAGATGTTCGTTCTCGCT
TTAAGTCAGGAGTCACAAATGACTTTTTTTTTTCAATTAAGGAAAAAGCTCCATCTCTACCTTTAACATCACCCAGACCCCCGCCCCTGC
CCGTGCCCCACGCTGCTGCTAACGACAGTATGATGCTTACTCTGCTACTCGGAAACTATTTTTATGTAATTAATGTATGCTTTCTTGTTT

>62562_62562_2_PANK4-SKI_PANK4_chr1_2457903_ENST00000435556_SKI_chr1_2234417_ENST00000378536_length(amino acids)=385AA_BP=
MNLASRKFCSGFQNYMVTNTRLVIGTVRRCAVWAAGAEPGGAAPPSRAPLHPRCRRRCGGRHGIYGSSSAAPSLPAASGRARGHSCSCSS
FTTFSRCSRASRSRSRSARSCSRSASACCSFTCRSSIWAEYLARRRPASQPLSHTRACRACSSSRFRRSRDSLASFIFFSFSARRRSISF
RRLRLASVASRSFSFLATRRNSSSWWRLRLACRAALSFSSCFTRILTTSCRNFSLASLVSRPPSSACRRCSSSASSPLGASAGAAASGTA
EGRARAPGEPRSLAELDEVKDGEESEDKEEVNSSLLSTSTSASESLSSSGAATGASVSGAPGVSTVSFRFRGWVQVARGSGARETAAAHG

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Fusion Gene PPI Analysis for PANK4-SKI

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PANK4-SKI

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PANK4-SKI

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source