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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PAPD7-RAF1 (FusionGDB2 ID:62587)

Fusion Gene Summary for PAPD7-RAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: PAPD7-RAF1
Fusion gene ID: 62587
HgeneTgene
Gene symbol

PAPD7

RAF1

Gene ID

11044

6037

Gene nameterminal nucleotidyltransferase 4Aribonuclease A family member 3
SynonymsLAK-1|LAK1|PAPD7|POLK|POLS|TRF4|TRF4-1|TRF41|TUTASE5ECP|RAF1|RNS3
Cytomap

5p15.31

14q11.2

Type of geneprotein-codingprotein-coding
Descriptionterminal nucleotidyltransferase 4ADNA polymerase kappaDNA polymerase sigmaPAP-associated domain-containing protein 7TRAMP-like complex polyadenylate polymerasenon-canonical poly(A) RNA polymerase PAPD7poly(A) RNA polymerase D7, non-canonicalpolymereosinophil cationic proteinRNase 3cytotoxic ribonucleaseribonuclease 3ribonuclease, RNase A family, 3
Modification date2020031320200313
UniProtAcc.

P04049

Ensembl transtripts involved in fusion geneENST00000230859, ENST00000251849, 
ENST00000442415, ENST00000534997, 
ENST00000542177, 
Fusion gene scores* DoF score8 X 9 X 7=50419 X 16 X 7=2128
# samples 1018
** MAII scorelog2(10/504*10)=-2.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2128*10)=-3.56342933917152
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAPD7 [Title/Abstract] AND RAF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPAPD7(6751310)-RAF1(12641307), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAPD7

GO:0042493

response to drug

10066793

TgeneRAF1

GO:0002227

innate immune response in mucosa

12860195

TgeneRAF1

GO:0019731

antibacterial humoral response

12860195

TgeneRAF1

GO:0043152

induction of bacterial agglutination

23992292

TgeneRAF1

GO:0045087

innate immune response

23992292

TgeneRAF1

GO:0050829

defense response to Gram-negative bacterium

23992292

TgeneRAF1

GO:0050830

defense response to Gram-positive bacterium

12860195|23992292

TgeneRAF1

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

12860195


check buttonFusion gene breakpoints across PAPD7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-8256-01APAPD7chr5

6751310

-RAF1chr3

12641307

-
ChimerDB4PRADTCGA-HC-8256-01APAPD7chr5

6751310

+RAF1chr3

12641307

-
ChimerDB4PRADTCGA-HC-8256PAPD7chr5

6751310

+RAF1chr3

12641307

-


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Fusion Gene ORF analysis for PAPD7-RAF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000230859ENST00000251849PAPD7chr5

6751310

+RAF1chr3

12641307

-
In-frameENST00000230859ENST00000442415PAPD7chr5

6751310

+RAF1chr3

12641307

-
In-frameENST00000230859ENST00000534997PAPD7chr5

6751310

+RAF1chr3

12641307

-
In-frameENST00000230859ENST00000542177PAPD7chr5

6751310

+RAF1chr3

12641307

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000230859PAPD7chr56751310+ENST00000251849RAF1chr312641307-326813981292354741
ENST00000230859PAPD7chr56751310+ENST00000442415RAF1chr312641307-307113981292354741
ENST00000230859PAPD7chr56751310+ENST00000534997RAF1chr312641307-260213981292354741
ENST00000230859PAPD7chr56751310+ENST00000542177RAF1chr312641307-253613981292354741

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000230859ENST00000251849PAPD7chr56751310+RAF1chr312641307-0.0041694030.9958306
ENST00000230859ENST00000442415PAPD7chr56751310+RAF1chr312641307-0.0065454130.9934546
ENST00000230859ENST00000534997PAPD7chr56751310+RAF1chr312641307-0.0061699540.99383
ENST00000230859ENST00000542177PAPD7chr56751310+RAF1chr312641307-0.0062352650.99376476

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Fusion Genomic Features for PAPD7-RAF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PAPD7-RAF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:6751310/chr3:12641307)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RAF1

P04049

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAPD7chr5:6751310chr3:12641307ENST00000230859+111327_79423543.0Compositional biasNote=Ala-rich
HgenePAPD7chr5:6751310chr3:12641307ENST00000230859+111385_117423543.0Compositional biasNote=Ser-rich
TgeneRAF1chr5:6751310chr3:12641307ENST00000251849817349_609330649.0DomainProtein kinase
TgeneRAF1chr5:6751310chr3:12641307ENST00000442415918349_609350669.0DomainProtein kinase
TgeneRAF1chr5:6751310chr3:12641307ENST00000251849817355_363330649.0Nucleotide bindingATP
TgeneRAF1chr5:6751310chr3:12641307ENST00000442415918355_363350669.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAPD7chr5:6751310chr3:12641307ENST00000230859+1113576_602423543.0Compositional biasNote=Ser-rich
HgenePAPD7chr5:6751310chr3:12641307ENST00000230859+1113408_468423543.0DomainNote=PAP-associated
TgeneRAF1chr5:6751310chr3:12641307ENST0000025184981756_131330649.0DomainRBD
TgeneRAF1chr5:6751310chr3:12641307ENST0000044241591856_131350669.0DomainRBD
TgeneRAF1chr5:6751310chr3:12641307ENST00000251849817138_184330649.0Zinc fingerPhorbol-ester/DAG-type
TgeneRAF1chr5:6751310chr3:12641307ENST00000442415918138_184350669.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Gene Sequence for PAPD7-RAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>62587_62587_1_PAPD7-RAF1_PAPD7_chr5_6751310_ENST00000230859_RAF1_chr3_12641307_ENST00000251849_length(transcript)=3268nt_BP=1398nt
GCGGCCGCTCTCAGCGGAGGGGGCGGCCCCGGGGCCCAGGCGCCGCGGCCCGGCACCCCGTGGAAGAGCCGCGCGTACAGCCCGGGCATC
CAGGGACTACATGAGGAAATAATTGACTTTTATAACTTCATGTCCCCTTGTCCTGAAGAAGCAGCTATGAGAAGAGAGGTGGTGAAACGG
ATCGAAACTGTGGTGAAAGACCTTTGGCCGACGGCTGATGTACAGATATTTGGCAGCTTTAGTACAGGTCTTTATCTTCCAACTAGCGAC
ATAGACCTGGTGGTCTTCGGGAAATGGGAGCGTCCTCCTTTACAGCTGCTGGAGCAAGCCCTGCGGAAGCACAACGTGGCTGAGCCGTGT
TCCATCAAAGTCCTTGACAAGGCTACGGTACCAATAATAAAGCTCACAGATCAGGAGACTGAAGTGAAAGTTGACATCAGCTTTAACATG
GAGACGGGCGTCCGGGCAGCGGAGTTCATCAAGAATTACATGAAGAAATATTCATTGCTGCCTTACTTGATTTTAGTATTGAAACAGTTC
CTTCTGCAGAGGGACCTGAATGAAGTTTTTACAGGTGGAATTAGCTCATACAGCCTAATTTTAATGGCCATTAGCTTTCTACAGTTGCAT
CCAAGAATTGATGCCCGGAGAGCTGATGAAAACCTTGGAATGCTTCTTGTAGAATTTTTTGAACTCTATGGGAGAAATTTTAATTACTTG
AAAACCGGTATTAGAATCAAAGAAGGAGGTGCCTATATCGCCAAAGAGGAGATCATGAAAGCCATGACCAGCGGGTACAGACCGTCGATG
CTGTGCATTGAGGACCCCCTGCTGCCAGGGAATGACGTTGGCCGGAGCTCCTATGGCGCCATGCAGGTGAAGCAGGTCTTCGATTATGCC
TACATAGTGCTCAGCCATGCTGTGTCACCGCTGGCCAGGTCCTATCCAAACAGAGACGCCGAAAGTACTTTAGGAAGAATCATCAAAGTA
ACTCAGGAGGTGATTGACTACCGGAGGTGGATCAAAGAGAAGTGGGGCAGCAAAGCCCACCCGTCGCCAGGCATGGACAGCAGGATCAAG
ATCAAAGAGCGAATAGCCACATGCAATGGGGAGCAGACGCAGAACCGAGAGCCCGAGTCTCCCTATGGCCAGCGCTTGACTTTGTCGCTG
TCCAGCCCCCAGCTCCTGTCTTCAGGCTCCTCGGCCTCTTCTGTGTCTTCACTTTCTGGGAGTGACGTTGATTCAGACACACCGCCCTGC
ACAACGCCCAGTGTTTACCAGTTCAGTCTGCAAGCGCCAGCTCCTCTCATGGCCGGCTTACCCACCGCCTTGCCAATGCCCAGTGGCAAA
CCTCAGCCCACCACTTCCAGAACACTGATCATGACAACCAACAATCAGAGGCCTCGTGGACAGAGAGATTCAAGCTATTATTGGGAAATA
GAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGATGTTGCAGTA
AAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACGGCATGTGAAC
ATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAAACACCTGCAT
GTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGCAAAGAACATC
ATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAACAGTAAAGTCA
CGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGATAACAACCCA
TTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACATCAACAACCGA
GATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAATGAAGAGGCTG
GTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACACTCTCTACCG
AAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCACGTCCCCGAGG
CTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTGCTCCCTTTCT
CCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTGCCTTCTTTTC
TATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCCCCACATTCCCCATGCTCAAGGCCCAGCCT
TCTGTAGATGCGCAAGTGGATGTTGATGGTAGTACAAAAAGCAGGGGCCCAGCCCCAGCTGTTGGCTACATGAGTATTTAGAGGAAGTAA
GGTAGCAGGCAGTCCAGCCCTGATGTGGAGACACATGGGATTTTGGAAATCAGCTTCTGGAGGAATGCATGTCACAGGCGGGACTTTCTT
CAGAGAGTGGTGCAGCGCCAGACATTTTGCACATAAGGCACCAAACAGCCCAGGACTGCCGAGACTCTGGCCGCCCGAAGGAGCCTGCTT
TGGTACTATGGAACTTTTCTTAGGGGACACGTCCTCCTTTCACAGCTTCTAAGGTGTCCAGTGCATTGGGATGGTTTTCCAGGCAAGGCA
CTCGGCCAATCCGCATCTCAGCCCTCTCAGGGAGCAGTCTTCCATCATGCTGAATTTTGTCTTCCAGGAGCTGCCCCTATGGGGCGGGGC
CGCAGGGCCAGCCTTGTTTCTCTAACAAACAAACAAACAAACAGCCTTGTTTCTCTAGTCACATCATGTGTATACAAGGAAGCCAGGAAT
ACAGGTTTTCTTGATGATTTGGGTTTTAATTTTGTTTTTATTGCACCTGACAAAATACAGTTATCTGATGGTCCCTCAATTATGTTATTT

>62587_62587_1_PAPD7-RAF1_PAPD7_chr5_6751310_ENST00000230859_RAF1_chr3_12641307_ENST00000251849_length(amino acids)=741AA_BP=422
MSPCPEEAAMRREVVKRIETVVKDLWPTADVQIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRKHNVAEPCSIKVLDKATVPII
KLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFTGGISSYSLILMAISFLQLHPRIDARRADENLG
MLLVEFFELYGRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLSHAVSPLAR
SYPNRDAESTLGRIIKVTQEVIDYRRWIKEKWGSKAHPSPGMDSRIKIKERIATCNGEQTQNREPESPYGQRLTLSLSSPQLLSSGSSAS
SVSSLSGSDVDSDTPPCTTPSVYQFSLQAPAPLMAGLPTALPMPSGKPQPTTSRTLIMTTNNQRPRGQRDSSYYWEIEASEVMLSTRIGS
GSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLID
IARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIV
LYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHR

--------------------------------------------------------------
>62587_62587_2_PAPD7-RAF1_PAPD7_chr5_6751310_ENST00000230859_RAF1_chr3_12641307_ENST00000442415_length(transcript)=3071nt_BP=1398nt
GCGGCCGCTCTCAGCGGAGGGGGCGGCCCCGGGGCCCAGGCGCCGCGGCCCGGCACCCCGTGGAAGAGCCGCGCGTACAGCCCGGGCATC
CAGGGACTACATGAGGAAATAATTGACTTTTATAACTTCATGTCCCCTTGTCCTGAAGAAGCAGCTATGAGAAGAGAGGTGGTGAAACGG
ATCGAAACTGTGGTGAAAGACCTTTGGCCGACGGCTGATGTACAGATATTTGGCAGCTTTAGTACAGGTCTTTATCTTCCAACTAGCGAC
ATAGACCTGGTGGTCTTCGGGAAATGGGAGCGTCCTCCTTTACAGCTGCTGGAGCAAGCCCTGCGGAAGCACAACGTGGCTGAGCCGTGT
TCCATCAAAGTCCTTGACAAGGCTACGGTACCAATAATAAAGCTCACAGATCAGGAGACTGAAGTGAAAGTTGACATCAGCTTTAACATG
GAGACGGGCGTCCGGGCAGCGGAGTTCATCAAGAATTACATGAAGAAATATTCATTGCTGCCTTACTTGATTTTAGTATTGAAACAGTTC
CTTCTGCAGAGGGACCTGAATGAAGTTTTTACAGGTGGAATTAGCTCATACAGCCTAATTTTAATGGCCATTAGCTTTCTACAGTTGCAT
CCAAGAATTGATGCCCGGAGAGCTGATGAAAACCTTGGAATGCTTCTTGTAGAATTTTTTGAACTCTATGGGAGAAATTTTAATTACTTG
AAAACCGGTATTAGAATCAAAGAAGGAGGTGCCTATATCGCCAAAGAGGAGATCATGAAAGCCATGACCAGCGGGTACAGACCGTCGATG
CTGTGCATTGAGGACCCCCTGCTGCCAGGGAATGACGTTGGCCGGAGCTCCTATGGCGCCATGCAGGTGAAGCAGGTCTTCGATTATGCC
TACATAGTGCTCAGCCATGCTGTGTCACCGCTGGCCAGGTCCTATCCAAACAGAGACGCCGAAAGTACTTTAGGAAGAATCATCAAAGTA
ACTCAGGAGGTGATTGACTACCGGAGGTGGATCAAAGAGAAGTGGGGCAGCAAAGCCCACCCGTCGCCAGGCATGGACAGCAGGATCAAG
ATCAAAGAGCGAATAGCCACATGCAATGGGGAGCAGACGCAGAACCGAGAGCCCGAGTCTCCCTATGGCCAGCGCTTGACTTTGTCGCTG
TCCAGCCCCCAGCTCCTGTCTTCAGGCTCCTCGGCCTCTTCTGTGTCTTCACTTTCTGGGAGTGACGTTGATTCAGACACACCGCCCTGC
ACAACGCCCAGTGTTTACCAGTTCAGTCTGCAAGCGCCAGCTCCTCTCATGGCCGGCTTACCCACCGCCTTGCCAATGCCCAGTGGCAAA
CCTCAGCCCACCACTTCCAGAACACTGATCATGACAACCAACAATCAGAGGCCTCGTGGACAGAGAGATTCAAGCTATTATTGGGAAATA
GAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGATGTTGCAGTA
AAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACGGCATGTGAAC
ATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAAACACCTGCAT
GTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGCAAAGAACATC
ATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAACAGTAAAGTCA
CGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGATAACAACCCA
TTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACATCAACAACCGA
GATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAATGAAGAGGCTG
GTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACACTCTCTACCG
AAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCACGTCCCCGAGG
CTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTGCTCCCTTTCT
CCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTGCCTTCTTTTC
TATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCCCCACATTCCCCATGCTCAAGGCCCAGCCT
TCTGTAGATGCGCAAGTGGATGTTGATGGTAGTACAAAAAGCAGGGGCCCAGCCCCAGCTGTTGGCTACATGAGTATTTAGAGGAAGTAA
GGTAGCAGGCAGTCCAGCCCTGATGTGGAGACACATGGGATTTTGGAAATCAGCTTCTGGAGGAATGCATGTCACAGGCGGGACTTTCTT
CAGAGAGTGGTGCAGCGCCAGACATTTTGCACATAAGGCACCAAACAGCCCAGGACTGCCGAGACTCTGGCCGCCCGAAGGAGCCTGCTT
TGGTACTATGGAACTTTTCTTAGGGGACACGTCCTCCTTTCACAGCTTCTAAGGTGTCCAGTGCATTGGGATGGTTTTCCAGGCAAGGCA
CTCGGCCAATCCGCATCTCAGCCCTCTCAGGGAGCAGTCTTCCATCATGCTGAATTTTGTCTTCCAGGAGCTGCCCCTATGGGGCGGGGC

>62587_62587_2_PAPD7-RAF1_PAPD7_chr5_6751310_ENST00000230859_RAF1_chr3_12641307_ENST00000442415_length(amino acids)=741AA_BP=422
MSPCPEEAAMRREVVKRIETVVKDLWPTADVQIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRKHNVAEPCSIKVLDKATVPII
KLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFTGGISSYSLILMAISFLQLHPRIDARRADENLG
MLLVEFFELYGRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLSHAVSPLAR
SYPNRDAESTLGRIIKVTQEVIDYRRWIKEKWGSKAHPSPGMDSRIKIKERIATCNGEQTQNREPESPYGQRLTLSLSSPQLLSSGSSAS
SVSSLSGSDVDSDTPPCTTPSVYQFSLQAPAPLMAGLPTALPMPSGKPQPTTSRTLIMTTNNQRPRGQRDSSYYWEIEASEVMLSTRIGS
GSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLID
IARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIV
LYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHR

--------------------------------------------------------------
>62587_62587_3_PAPD7-RAF1_PAPD7_chr5_6751310_ENST00000230859_RAF1_chr3_12641307_ENST00000534997_length(transcript)=2602nt_BP=1398nt
GCGGCCGCTCTCAGCGGAGGGGGCGGCCCCGGGGCCCAGGCGCCGCGGCCCGGCACCCCGTGGAAGAGCCGCGCGTACAGCCCGGGCATC
CAGGGACTACATGAGGAAATAATTGACTTTTATAACTTCATGTCCCCTTGTCCTGAAGAAGCAGCTATGAGAAGAGAGGTGGTGAAACGG
ATCGAAACTGTGGTGAAAGACCTTTGGCCGACGGCTGATGTACAGATATTTGGCAGCTTTAGTACAGGTCTTTATCTTCCAACTAGCGAC
ATAGACCTGGTGGTCTTCGGGAAATGGGAGCGTCCTCCTTTACAGCTGCTGGAGCAAGCCCTGCGGAAGCACAACGTGGCTGAGCCGTGT
TCCATCAAAGTCCTTGACAAGGCTACGGTACCAATAATAAAGCTCACAGATCAGGAGACTGAAGTGAAAGTTGACATCAGCTTTAACATG
GAGACGGGCGTCCGGGCAGCGGAGTTCATCAAGAATTACATGAAGAAATATTCATTGCTGCCTTACTTGATTTTAGTATTGAAACAGTTC
CTTCTGCAGAGGGACCTGAATGAAGTTTTTACAGGTGGAATTAGCTCATACAGCCTAATTTTAATGGCCATTAGCTTTCTACAGTTGCAT
CCAAGAATTGATGCCCGGAGAGCTGATGAAAACCTTGGAATGCTTCTTGTAGAATTTTTTGAACTCTATGGGAGAAATTTTAATTACTTG
AAAACCGGTATTAGAATCAAAGAAGGAGGTGCCTATATCGCCAAAGAGGAGATCATGAAAGCCATGACCAGCGGGTACAGACCGTCGATG
CTGTGCATTGAGGACCCCCTGCTGCCAGGGAATGACGTTGGCCGGAGCTCCTATGGCGCCATGCAGGTGAAGCAGGTCTTCGATTATGCC
TACATAGTGCTCAGCCATGCTGTGTCACCGCTGGCCAGGTCCTATCCAAACAGAGACGCCGAAAGTACTTTAGGAAGAATCATCAAAGTA
ACTCAGGAGGTGATTGACTACCGGAGGTGGATCAAAGAGAAGTGGGGCAGCAAAGCCCACCCGTCGCCAGGCATGGACAGCAGGATCAAG
ATCAAAGAGCGAATAGCCACATGCAATGGGGAGCAGACGCAGAACCGAGAGCCCGAGTCTCCCTATGGCCAGCGCTTGACTTTGTCGCTG
TCCAGCCCCCAGCTCCTGTCTTCAGGCTCCTCGGCCTCTTCTGTGTCTTCACTTTCTGGGAGTGACGTTGATTCAGACACACCGCCCTGC
ACAACGCCCAGTGTTTACCAGTTCAGTCTGCAAGCGCCAGCTCCTCTCATGGCCGGCTTACCCACCGCCTTGCCAATGCCCAGTGGCAAA
CCTCAGCCCACCACTTCCAGAACACTGATCATGACAACCAACAATCAGAGGCCTCGTGGACAGAGAGATTCAAGCTATTATTGGGAAATA
GAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGATGTTGCAGTA
AAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACGGCATGTGAAC
ATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAAACACCTGCAT
GTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGCAAAGAACATC
ATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAACAGTAAAGTCA
CGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGATAACAACCCA
TTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACATCAACAACCGA
GATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAATGAAGAGGCTG
GTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACACTCTCTACCG
AAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCACGTCCCCGAGG
CTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTGCTCCCTTTCT
CCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTGCCTTCTTTTC

>62587_62587_3_PAPD7-RAF1_PAPD7_chr5_6751310_ENST00000230859_RAF1_chr3_12641307_ENST00000534997_length(amino acids)=741AA_BP=422
MSPCPEEAAMRREVVKRIETVVKDLWPTADVQIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRKHNVAEPCSIKVLDKATVPII
KLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFTGGISSYSLILMAISFLQLHPRIDARRADENLG
MLLVEFFELYGRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLSHAVSPLAR
SYPNRDAESTLGRIIKVTQEVIDYRRWIKEKWGSKAHPSPGMDSRIKIKERIATCNGEQTQNREPESPYGQRLTLSLSSPQLLSSGSSAS
SVSSLSGSDVDSDTPPCTTPSVYQFSLQAPAPLMAGLPTALPMPSGKPQPTTSRTLIMTTNNQRPRGQRDSSYYWEIEASEVMLSTRIGS
GSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLID
IARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIV
LYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHR

--------------------------------------------------------------
>62587_62587_4_PAPD7-RAF1_PAPD7_chr5_6751310_ENST00000230859_RAF1_chr3_12641307_ENST00000542177_length(transcript)=2536nt_BP=1398nt
GCGGCCGCTCTCAGCGGAGGGGGCGGCCCCGGGGCCCAGGCGCCGCGGCCCGGCACCCCGTGGAAGAGCCGCGCGTACAGCCCGGGCATC
CAGGGACTACATGAGGAAATAATTGACTTTTATAACTTCATGTCCCCTTGTCCTGAAGAAGCAGCTATGAGAAGAGAGGTGGTGAAACGG
ATCGAAACTGTGGTGAAAGACCTTTGGCCGACGGCTGATGTACAGATATTTGGCAGCTTTAGTACAGGTCTTTATCTTCCAACTAGCGAC
ATAGACCTGGTGGTCTTCGGGAAATGGGAGCGTCCTCCTTTACAGCTGCTGGAGCAAGCCCTGCGGAAGCACAACGTGGCTGAGCCGTGT
TCCATCAAAGTCCTTGACAAGGCTACGGTACCAATAATAAAGCTCACAGATCAGGAGACTGAAGTGAAAGTTGACATCAGCTTTAACATG
GAGACGGGCGTCCGGGCAGCGGAGTTCATCAAGAATTACATGAAGAAATATTCATTGCTGCCTTACTTGATTTTAGTATTGAAACAGTTC
CTTCTGCAGAGGGACCTGAATGAAGTTTTTACAGGTGGAATTAGCTCATACAGCCTAATTTTAATGGCCATTAGCTTTCTACAGTTGCAT
CCAAGAATTGATGCCCGGAGAGCTGATGAAAACCTTGGAATGCTTCTTGTAGAATTTTTTGAACTCTATGGGAGAAATTTTAATTACTTG
AAAACCGGTATTAGAATCAAAGAAGGAGGTGCCTATATCGCCAAAGAGGAGATCATGAAAGCCATGACCAGCGGGTACAGACCGTCGATG
CTGTGCATTGAGGACCCCCTGCTGCCAGGGAATGACGTTGGCCGGAGCTCCTATGGCGCCATGCAGGTGAAGCAGGTCTTCGATTATGCC
TACATAGTGCTCAGCCATGCTGTGTCACCGCTGGCCAGGTCCTATCCAAACAGAGACGCCGAAAGTACTTTAGGAAGAATCATCAAAGTA
ACTCAGGAGGTGATTGACTACCGGAGGTGGATCAAAGAGAAGTGGGGCAGCAAAGCCCACCCGTCGCCAGGCATGGACAGCAGGATCAAG
ATCAAAGAGCGAATAGCCACATGCAATGGGGAGCAGACGCAGAACCGAGAGCCCGAGTCTCCCTATGGCCAGCGCTTGACTTTGTCGCTG
TCCAGCCCCCAGCTCCTGTCTTCAGGCTCCTCGGCCTCTTCTGTGTCTTCACTTTCTGGGAGTGACGTTGATTCAGACACACCGCCCTGC
ACAACGCCCAGTGTTTACCAGTTCAGTCTGCAAGCGCCAGCTCCTCTCATGGCCGGCTTACCCACCGCCTTGCCAATGCCCAGTGGCAAA
CCTCAGCCCACCACTTCCAGAACACTGATCATGACAACCAACAATCAGAGGCCTCGTGGACAGAGAGATTCAAGCTATTATTGGGAAATA
GAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGATGTTGCAGTA
AAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACGGCATGTGAAC
ATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAAACACCTGCAT
GTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGCAAAGAACATC
ATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAACAGTAAAGTCA
CGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGATAACAACCCA
TTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACATCAACAACCGA
GATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAATGAAGAGGCTG
GTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACACTCTCTACCG
AAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCACGTCCCCGAGG
CTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTGCTCCCTTTCT
CCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTGCCTTCTTTTC

>62587_62587_4_PAPD7-RAF1_PAPD7_chr5_6751310_ENST00000230859_RAF1_chr3_12641307_ENST00000542177_length(amino acids)=741AA_BP=422
MSPCPEEAAMRREVVKRIETVVKDLWPTADVQIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRKHNVAEPCSIKVLDKATVPII
KLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFTGGISSYSLILMAISFLQLHPRIDARRADENLG
MLLVEFFELYGRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLSHAVSPLAR
SYPNRDAESTLGRIIKVTQEVIDYRRWIKEKWGSKAHPSPGMDSRIKIKERIATCNGEQTQNREPESPYGQRLTLSLSSPQLLSSGSSAS
SVSSLSGSDVDSDTPPCTTPSVYQFSLQAPAPLMAGLPTALPMPSGKPQPTTSRTLIMTTNNQRPRGQRDSSYYWEIEASEVMLSTRIGS
GSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLID
IARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIV
LYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PAPD7-RAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRAF1chr5:6751310chr3:12641307ENST00000251849817331_349330.0649.0PEBP1/RKIP


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneRAF1chr5:6751310chr3:12641307ENST00000442415918331_349350.0669.0PEBP1/RKIP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PAPD7-RAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PAPD7-RAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource