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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ARHGEF1-UCKL1 (FusionGDB2 ID:6261) |
Fusion Gene Summary for ARHGEF1-UCKL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGEF1-UCKL1 | Fusion gene ID: 6261 | Hgene | Tgene | Gene symbol | ARHGEF1 | UCKL1 | Gene ID | 9138 | 54963 |
| Gene name | Rho guanine nucleotide exchange factor 1 | uridine-cytidine kinase 1 like 1 | |
| Synonyms | GEF1|IMD62|LBCL2|LSC|P115-RHOGEF|SUB1.5 | UCK1L|URKL1 | |
| Cytomap | 19q13.2 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho guanine nucleotide exchange factor 1115 kDa guanine nucleotide exchange factor115-kD proteinLsc homologRho guanine nucleotide exchange factor (GEF) 1p115RhoGEF | uridine-cytidine kinase-like 1UCK1-LIKE | |
| Modification date | 20200320 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000337665, ENST00000347545, ENST00000354532, ENST00000378152, ENST00000599846, ENST00000596957, | ENST00000492660, ENST00000358711, ENST00000354216, ENST00000369892, ENST00000369908, | |
| Fusion gene scores | * DoF score | 11 X 9 X 6=594 | 6 X 3 X 3=54 |
| # samples | 12 | 6 | |
| ** MAII score | log2(12/594*10)=-2.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/54*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ARHGEF1 [Title/Abstract] AND UCKL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ARHGEF1(42400555)-UCKL1(62572561), # samples:4 | ||
| Anticipated loss of major functional domain due to fusion event. | ARHGEF1-UCKL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ARHGEF1-UCKL1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across ARHGEF1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across UCKL1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | COAD | TCGA-D5-6529-01A | ARHGEF1 | chr19 | 42400555 | - | UCKL1 | chr20 | 62572561 | - |
| ChimerDB4 | READ | TCGA-G5-6572-01A | ARHGEF1 | chr19 | 42400555 | - | UCKL1 | chr20 | 62572561 | - |
| ChimerDB4 | READ | TCGA-G5-6572 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
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Fusion Gene ORF analysis for ARHGEF1-UCKL1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000337665 | ENST00000492660 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| 5CDS-intron | ENST00000347545 | ENST00000492660 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| 5CDS-intron | ENST00000354532 | ENST00000492660 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| 5CDS-intron | ENST00000378152 | ENST00000492660 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| 5CDS-intron | ENST00000599846 | ENST00000492660 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| Frame-shift | ENST00000337665 | ENST00000358711 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| Frame-shift | ENST00000347545 | ENST00000358711 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| Frame-shift | ENST00000354532 | ENST00000358711 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| Frame-shift | ENST00000378152 | ENST00000358711 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| Frame-shift | ENST00000599846 | ENST00000358711 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000337665 | ENST00000354216 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000337665 | ENST00000369892 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000337665 | ENST00000369908 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000347545 | ENST00000354216 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000347545 | ENST00000369892 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000347545 | ENST00000369908 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000354532 | ENST00000354216 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000354532 | ENST00000369892 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000354532 | ENST00000369908 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000378152 | ENST00000354216 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000378152 | ENST00000369892 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000378152 | ENST00000369908 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000599846 | ENST00000354216 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000599846 | ENST00000369892 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| In-frame | ENST00000599846 | ENST00000369908 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| intron-3CDS | ENST00000596957 | ENST00000354216 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| intron-3CDS | ENST00000596957 | ENST00000358711 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| intron-3CDS | ENST00000596957 | ENST00000369892 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| intron-3CDS | ENST00000596957 | ENST00000369908 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| intron-intron | ENST00000596957 | ENST00000492660 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000354532 | ARHGEF1 | chr19 | 42400555 | + | ENST00000354216 | UCKL1 | chr20 | 62572561 | - | 2136 | 1269 | 148 | 1992 | 614 |
| ENST00000354532 | ARHGEF1 | chr19 | 42400555 | + | ENST00000369892 | UCKL1 | chr20 | 62572561 | - | 2129 | 1269 | 148 | 1320 | 390 |
| ENST00000354532 | ARHGEF1 | chr19 | 42400555 | + | ENST00000369908 | UCKL1 | chr20 | 62572561 | - | 2045 | 1269 | 148 | 1992 | 614 |
| ENST00000599846 | ARHGEF1 | chr19 | 42400555 | + | ENST00000354216 | UCKL1 | chr20 | 62572561 | - | 2113 | 1246 | 125 | 1969 | 614 |
| ENST00000599846 | ARHGEF1 | chr19 | 42400555 | + | ENST00000369892 | UCKL1 | chr20 | 62572561 | - | 2106 | 1246 | 125 | 1297 | 390 |
| ENST00000599846 | ARHGEF1 | chr19 | 42400555 | + | ENST00000369908 | UCKL1 | chr20 | 62572561 | - | 2022 | 1246 | 125 | 1969 | 614 |
| ENST00000347545 | ARHGEF1 | chr19 | 42400555 | + | ENST00000354216 | UCKL1 | chr20 | 62572561 | - | 1973 | 1106 | 84 | 1829 | 581 |
| ENST00000347545 | ARHGEF1 | chr19 | 42400555 | + | ENST00000369892 | UCKL1 | chr20 | 62572561 | - | 1966 | 1106 | 84 | 1157 | 357 |
| ENST00000347545 | ARHGEF1 | chr19 | 42400555 | + | ENST00000369908 | UCKL1 | chr20 | 62572561 | - | 1882 | 1106 | 84 | 1829 | 581 |
| ENST00000378152 | ARHGEF1 | chr19 | 42400555 | + | ENST00000354216 | UCKL1 | chr20 | 62572561 | - | 2032 | 1165 | 98 | 1888 | 596 |
| ENST00000378152 | ARHGEF1 | chr19 | 42400555 | + | ENST00000369892 | UCKL1 | chr20 | 62572561 | - | 2025 | 1165 | 98 | 1216 | 372 |
| ENST00000378152 | ARHGEF1 | chr19 | 42400555 | + | ENST00000369908 | UCKL1 | chr20 | 62572561 | - | 1941 | 1165 | 98 | 1888 | 596 |
| ENST00000337665 | ARHGEF1 | chr19 | 42400555 | + | ENST00000354216 | UCKL1 | chr20 | 62572561 | - | 2053 | 1186 | 20 | 1909 | 629 |
| ENST00000337665 | ARHGEF1 | chr19 | 42400555 | + | ENST00000369892 | UCKL1 | chr20 | 62572561 | - | 2046 | 1186 | 20 | 1237 | 405 |
| ENST00000337665 | ARHGEF1 | chr19 | 42400555 | + | ENST00000369908 | UCKL1 | chr20 | 62572561 | - | 1962 | 1186 | 20 | 1909 | 629 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000354532 | ENST00000354216 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.018050747 | 0.98194927 |
| ENST00000354532 | ENST00000369892 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.027259419 | 0.97274053 |
| ENST00000354532 | ENST00000369908 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.02276395 | 0.97723603 |
| ENST00000599846 | ENST00000354216 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.018708847 | 0.9812912 |
| ENST00000599846 | ENST00000369892 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.027456539 | 0.9725434 |
| ENST00000599846 | ENST00000369908 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.023519734 | 0.97648025 |
| ENST00000347545 | ENST00000354216 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.016907787 | 0.98309225 |
| ENST00000347545 | ENST00000369892 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.012936478 | 0.9870635 |
| ENST00000347545 | ENST00000369908 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.022009129 | 0.97799087 |
| ENST00000378152 | ENST00000354216 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.013811802 | 0.98618823 |
| ENST00000378152 | ENST00000369892 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.017713718 | 0.9822863 |
| ENST00000378152 | ENST00000369908 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.018811123 | 0.98118895 |
| ENST00000337665 | ENST00000354216 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.017054869 | 0.98294514 |
| ENST00000337665 | ENST00000369892 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.02810594 | 0.971894 |
| ENST00000337665 | ENST00000369908 | ARHGEF1 | chr19 | 42400555 | + | UCKL1 | chr20 | 62572561 | - | 0.023210846 | 0.9767892 |
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Fusion Genomic Features for ARHGEF1-UCKL1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ARHGEF1-UCKL1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:42400555/chr20:62572561) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ARHGEF1 | chr19:42400555 | chr20:62572561 | ENST00000337665 | + | 13 | 29 | 41_232 | 388 | 1029.3333333333333 | Domain | Note=RGSL |
| Hgene | ARHGEF1 | chr19:42400555 | chr20:62572561 | ENST00000347545 | + | 12 | 28 | 41_232 | 340 | 975.0 | Domain | Note=RGSL |
| Hgene | ARHGEF1 | chr19:42400555 | chr20:62572561 | ENST00000354532 | + | 13 | 29 | 41_232 | 373 | 983.0 | Domain | Note=RGSL |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ARHGEF1 | chr19:42400555 | chr20:62572561 | ENST00000337665 | + | 13 | 29 | 865_896 | 388 | 1029.3333333333333 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ARHGEF1 | chr19:42400555 | chr20:62572561 | ENST00000347545 | + | 12 | 28 | 865_896 | 340 | 975.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ARHGEF1 | chr19:42400555 | chr20:62572561 | ENST00000354532 | + | 13 | 29 | 865_896 | 373 | 983.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ARHGEF1 | chr19:42400555 | chr20:62572561 | ENST00000337665 | + | 13 | 29 | 416_605 | 388 | 1029.3333333333333 | Domain | DH |
| Hgene | ARHGEF1 | chr19:42400555 | chr20:62572561 | ENST00000337665 | + | 13 | 29 | 647_760 | 388 | 1029.3333333333333 | Domain | PH |
| Hgene | ARHGEF1 | chr19:42400555 | chr20:62572561 | ENST00000347545 | + | 12 | 28 | 416_605 | 340 | 975.0 | Domain | DH |
| Hgene | ARHGEF1 | chr19:42400555 | chr20:62572561 | ENST00000347545 | + | 12 | 28 | 647_760 | 340 | 975.0 | Domain | PH |
| Hgene | ARHGEF1 | chr19:42400555 | chr20:62572561 | ENST00000354532 | + | 13 | 29 | 416_605 | 373 | 983.0 | Domain | DH |
| Hgene | ARHGEF1 | chr19:42400555 | chr20:62572561 | ENST00000354532 | + | 13 | 29 | 647_760 | 373 | 983.0 | Domain | PH |
| Tgene | UCKL1 | chr19:42400555 | chr20:62572561 | ENST00000354216 | 7 | 15 | 105_112 | 307 | 549.0 | Nucleotide binding | ATP | |
| Tgene | UCKL1 | chr19:42400555 | chr20:62572561 | ENST00000358711 | 6 | 13 | 105_112 | 302 | 412.6666666666667 | Nucleotide binding | ATP | |
| Tgene | UCKL1 | chr19:42400555 | chr20:62572561 | ENST00000369908 | 7 | 15 | 105_112 | 292 | 534.0 | Nucleotide binding | ATP |
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Fusion Gene Sequence for ARHGEF1-UCKL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >6261_6261_1_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000337665_UCKL1_chr20_62572561_ENST00000354216_length(transcript)=2053nt_BP=1186nt CTTCGGTTCCGGTGGCGGCGATGGCTTCTCTTTCCACCTGGAGCAGCCCTGCAGAGCCCAGGGAGATGGAAGACTTCGCCCGAGGGGCGG CCTCCCCAGGCCCCTCCCGGCCTGGCCTGGTTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAGAACGAGCTGGAGACAAACT CAGAAGAGCAAAACAGCCAGTTCCAGAGCCTGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTCCTGCAGCACGTGGCCCTGC AGTTTGAGCCAGGACCCCTGCTTTGCTGTCTGCATGCCGACATGCTGGGCTCACTGGGCCCCAAGGAGGCCAAGAAGGCCTTCCTGGACT TCTACCACAGCTTCCTGGAGAAGACAGCGGTTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACTAGGGCTGACC TCATCTCCGAGGATGTCCAGCGGCGGTTCGTGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAGGACTTCCGTT CCAAGCGGCTCATGGGCATGACGCCCTGGGAGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGCTACGAGGCCC GGGAGCGGCACGTGGCGGAGCGGCTGCTCATGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGTGCTGCCGTGG TCAACGCCATTGGCCTGTACATGCGCCACCTTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTCCGGAAAAAGG TGATGGGGAACCGGCGGTCGGACGAGCCTGCCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAACCGGGGAGAGC CCCAGGTTCCAGATTTTCGACACCTCAAAGCAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTGGGGATGCCCT CTCGGGACCGGAATATCGGGGCTCCTGGGCAGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGACCGGGAACCAG GTGCTGACGCCCCCCTGGAGCTGGGGGACTCATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGTACCGACGAGG GGGCCGAAACCGAGAGGGCTGCGCTGGCCTCGGCACACCAGTGCCACCCGCTGCCCCGGACGCTGAGCGTCCTGAAGAGCACGCCGCAGG TACGGGGCATGCACACCATCATCAGGGACAAGGAGACCAGTCGCGACGAGTTCATCTTCTACTCCAAGAGACTGATGCGGCTGCTCATCG AGCACGCGCTCTCCTTCCTGCCCTTTCAGGACTGCGTCGTACAGACCCCGCAGGGGCAGGACTATGCGGGCAAGTGCTATGCGGGGAAGC AGATCACCGGTGTGTCCATTCTGCGCGCCGGTGAAACCATGGAGCCCGCGCTGCGCGCTGTGTGCAAAGACGTGCGCATCGGCACCATCC TCATCCAGACCAACCAGCTTACCGGGGAGCCCGAGCTCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTGATCCTCATGG ACTGCACCGTGTCCACGGGCGCGGCGGCCATGATGGCAGTGCGCGTGCTCCTGGACCACGACGTGCCTGAGGACAAGATCTTTTTGCTGT CGCTGCTCATGGCAGAGATGGGCGTGCACTCAGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGACAAGCGGGTCA ATGACCTTTTCCGCATCATCCCAGGCATTGGGAACTTTGGCGACCGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGTGACGAGGAGG AAGTGGCCTACACGGGTTAGCTGCCCAGTGAGCCATCCCGTCCCCACCACCCTCCTCCTGCCTCCTGACCCAGGACTGCTGAATACAAAG >6261_6261_1_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000337665_UCKL1_chr20_62572561_ENST00000354216_length(amino acids)=629AA_BP=388 MASLSTWSSPAEPREMEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPL LCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGM TPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRS DEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLE LGDSSPQGPMSLESLAPPESTDEGAETERAALASAHQCHPLPRTLSVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFL PFQDCVVQTPQGQDYAGKCYAGKQITGVSILRAGETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTG -------------------------------------------------------------- >6261_6261_2_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000337665_UCKL1_chr20_62572561_ENST00000369892_length(transcript)=2046nt_BP=1186nt CTTCGGTTCCGGTGGCGGCGATGGCTTCTCTTTCCACCTGGAGCAGCCCTGCAGAGCCCAGGGAGATGGAAGACTTCGCCCGAGGGGCGG CCTCCCCAGGCCCCTCCCGGCCTGGCCTGGTTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAGAACGAGCTGGAGACAAACT CAGAAGAGCAAAACAGCCAGTTCCAGAGCCTGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTCCTGCAGCACGTGGCCCTGC AGTTTGAGCCAGGACCCCTGCTTTGCTGTCTGCATGCCGACATGCTGGGCTCACTGGGCCCCAAGGAGGCCAAGAAGGCCTTCCTGGACT TCTACCACAGCTTCCTGGAGAAGACAGCGGTTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACTAGGGCTGACC TCATCTCCGAGGATGTCCAGCGGCGGTTCGTGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAGGACTTCCGTT CCAAGCGGCTCATGGGCATGACGCCCTGGGAGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGCTACGAGGCCC GGGAGCGGCACGTGGCGGAGCGGCTGCTCATGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGTGCTGCCGTGG TCAACGCCATTGGCCTGTACATGCGCCACCTTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTCCGGAAAAAGG TGATGGGGAACCGGCGGTCGGACGAGCCTGCCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAACCGGGGAGAGC CCCAGGTTCCAGATTTTCGACACCTCAAAGCAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTGGGGATGCCCT CTCGGGACCGGAATATCGGGGCTCCTGGGCAGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGACCGGGAACCAG GTGCTGACGCCCCCCTGGAGCTGGGGGACTCATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGTACCGACGAGG GGGCCGAAACCGAGAGGGAACTTTGGCGACCGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGTGACGAGGAGGAAGTGGCCTACACG GGTTAGCTGCCCAGTGAGCCATCCCGTCCCCACCACCCTCCTCCTGCCTCCTGACCCAGGACTGCTGAATACAAAGATGTTAATTTTTAA AATGTTACTAGTATAATTTATTCTATGCATTTTATAAAATAAATAAAGCTTTGACCACGACGTGCCTGAGGACAAGATCTTTTTGCTGTC GCTGCTCATGGCAGAGATGGGCGTGCACTCAGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGACAAGCGGGTCAA TGACCTTTTCCGCATCATCCCAGGCATTGCTCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTGATCCTCATGGACTGCA CCGTGTCCACGGGCGCGGCGGCCATGATGGCAGTGCGCGTGCTCCTGATCACCGGTGTGTCCATTCTGCGCGCCGGTGAAACCATGGAGC CCGCGCTGCGCGCTGTGTGCAAAGACGTGCGCATCGGCACCATCCTCATCCAGACCAACCAGCTTACCGGGGAGCCCGAGGACTGCGTCG TACAGACCCCGCAGGGGCAGGACTATGCGGGCAAGTGCTATGCGGGGAAGCAGGGACAAGGAGACCAGTCGCGACGAGTTCATCTTCTAC TCCAAGAGACTGATGCGGCTGCTCATCGAGCACGCGCTCTCCTTCCTGCCCTTTCAGGGCTGCGCTGGCCTCGGCACACCAGTGCCACCC >6261_6261_2_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000337665_UCKL1_chr20_62572561_ENST00000369892_length(amino acids)=405AA_BP= MASLSTWSSPAEPREMEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPL LCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGM TPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRS DEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLE -------------------------------------------------------------- >6261_6261_3_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000337665_UCKL1_chr20_62572561_ENST00000369908_length(transcript)=1962nt_BP=1186nt CTTCGGTTCCGGTGGCGGCGATGGCTTCTCTTTCCACCTGGAGCAGCCCTGCAGAGCCCAGGGAGATGGAAGACTTCGCCCGAGGGGCGG CCTCCCCAGGCCCCTCCCGGCCTGGCCTGGTTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAGAACGAGCTGGAGACAAACT CAGAAGAGCAAAACAGCCAGTTCCAGAGCCTGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTCCTGCAGCACGTGGCCCTGC AGTTTGAGCCAGGACCCCTGCTTTGCTGTCTGCATGCCGACATGCTGGGCTCACTGGGCCCCAAGGAGGCCAAGAAGGCCTTCCTGGACT TCTACCACAGCTTCCTGGAGAAGACAGCGGTTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACTAGGGCTGACC TCATCTCCGAGGATGTCCAGCGGCGGTTCGTGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAGGACTTCCGTT CCAAGCGGCTCATGGGCATGACGCCCTGGGAGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGCTACGAGGCCC GGGAGCGGCACGTGGCGGAGCGGCTGCTCATGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGTGCTGCCGTGG TCAACGCCATTGGCCTGTACATGCGCCACCTTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTCCGGAAAAAGG TGATGGGGAACCGGCGGTCGGACGAGCCTGCCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAACCGGGGAGAGC CCCAGGTTCCAGATTTTCGACACCTCAAAGCAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTGGGGATGCCCT CTCGGGACCGGAATATCGGGGCTCCTGGGCAGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGACCGGGAACCAG GTGCTGACGCCCCCCTGGAGCTGGGGGACTCATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGTACCGACGAGG GGGCCGAAACCGAGAGGGCTGCGCTGGCCTCGGCACACCAGTGCCACCCGCTGCCCCGGACGCTGAGCGTCCTGAAGAGCACGCCGCAGG TACGGGGCATGCACACCATCATCAGGGACAAGGAGACCAGTCGCGACGAGTTCATCTTCTACTCCAAGAGACTGATGCGGCTGCTCATCG AGCACGCGCTCTCCTTCCTGCCCTTTCAGGACTGCGTCGTACAGACCCCGCAGGGGCAGGACTATGCGGGCAAGTGCTATGCGGGGAAGC AGATCACCGGTGTGTCCATTCTGCGCGCCGGTGAAACCATGGAGCCCGCGCTGCGCGCTGTGTGCAAAGACGTGCGCATCGGCACCATCC TCATCCAGACCAACCAGCTTACCGGGGAGCCCGAGCTCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTGATCCTCATGG ACTGCACCGTGTCCACGGGCGCGGCGGCCATGATGGCAGTGCGCGTGCTCCTGGACCACGACGTGCCTGAGGACAAGATCTTTTTGCTGT CGCTGCTCATGGCAGAGATGGGCGTGCACTCAGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGACAAGCGGGTCA ATGACCTTTTCCGCATCATCCCAGGCATTGGGAACTTTGGCGACCGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGTGACGAGGAGG >6261_6261_3_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000337665_UCKL1_chr20_62572561_ENST00000369908_length(amino acids)=629AA_BP=388 MASLSTWSSPAEPREMEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPL LCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGM TPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRS DEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLE LGDSSPQGPMSLESLAPPESTDEGAETERAALASAHQCHPLPRTLSVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFL PFQDCVVQTPQGQDYAGKCYAGKQITGVSILRAGETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTG -------------------------------------------------------------- >6261_6261_4_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000347545_UCKL1_chr20_62572561_ENST00000354216_length(transcript)=1973nt_BP=1106nt CCAGGGCCCGGGATCGCCGAGCCCGACCTCGGGCGCCCCGCCGGTCACCTCCGCGCGGACACCAGCCCTGCAGAGCCCAGGGAGATGGAA GACTTCGCCCGAGGGGCGGCCTCCCCAGGCCCCTCCCGGCCTGGCCTGGTTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAG AACGAGCTGGAGACAAACTCAGAAGAGCAAAACAGCCAGTTCCAGAGCCTGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTC CTGCAGCACGTGGCCCTGCAGTTTGAGCCAGGACCCCTGGTTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACT AGGGCTGACCTCATCTCCGAGGATGTCCAGCGGCGGTTCGTGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAG GACTTCCGTTCCAAGCGGCTCATGGGCATGACGCCCTGGGAGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGC TACGAGGCCCGGGAGCGGCACGTGGCGGAGCGGCTGCTCATGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGT GCTGCCGTGGTCAACGCCATTGGCCTGTACATGCGCCACCTTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTC CGGAAAAAGGTGATGGGGAACCGGCGGTCGGACGAGCCTGCCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAAC CGGGGAGAGCCCCAGGTTCCAGATTTTCGACACCTCAAAGCAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTG GGGATGCCCTCTCGGGACCGGAATATCGGGGCTCCTGGGCAGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGAC CGGGAACCAGGTGCTGACGCCCCCCTGGAGCTGGGGGACTCATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGT ACCGACGAGGGGGCCGAAACCGAGAGGGCTGCGCTGGCCTCGGCACACCAGTGCCACCCGCTGCCCCGGACGCTGAGCGTCCTGAAGAGC ACGCCGCAGGTACGGGGCATGCACACCATCATCAGGGACAAGGAGACCAGTCGCGACGAGTTCATCTTCTACTCCAAGAGACTGATGCGG CTGCTCATCGAGCACGCGCTCTCCTTCCTGCCCTTTCAGGACTGCGTCGTACAGACCCCGCAGGGGCAGGACTATGCGGGCAAGTGCTAT GCGGGGAAGCAGATCACCGGTGTGTCCATTCTGCGCGCCGGTGAAACCATGGAGCCCGCGCTGCGCGCTGTGTGCAAAGACGTGCGCATC GGCACCATCCTCATCCAGACCAACCAGCTTACCGGGGAGCCCGAGCTCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTG ATCCTCATGGACTGCACCGTGTCCACGGGCGCGGCGGCCATGATGGCAGTGCGCGTGCTCCTGGACCACGACGTGCCTGAGGACAAGATC TTTTTGCTGTCGCTGCTCATGGCAGAGATGGGCGTGCACTCAGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGAC AAGCGGGTCAATGACCTTTTCCGCATCATCCCAGGCATTGGGAACTTTGGCGACCGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGT GACGAGGAGGAAGTGGCCTACACGGGTTAGCTGCCCAGTGAGCCATCCCGTCCCCACCACCCTCCTCCTGCCTCCTGACCCAGGACTGCT >6261_6261_4_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000347545_UCKL1_chr20_62572561_ENST00000354216_length(amino acids)=581AA_BP=340 MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLVLRVPVPPNVAFELD RTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEE KSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATDRKG GVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETERAALASAHQCHPLPRTLSVL KSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQDYAGKCYAGKQITGVSILRAGETMEPALRAVCKDV RIGTILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTGAAAMMAVRVLLDHDVPEDKIFLLSLLMAEMGVHSVAYAFPRVRIITTA -------------------------------------------------------------- >6261_6261_5_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000347545_UCKL1_chr20_62572561_ENST00000369892_length(transcript)=1966nt_BP=1106nt CCAGGGCCCGGGATCGCCGAGCCCGACCTCGGGCGCCCCGCCGGTCACCTCCGCGCGGACACCAGCCCTGCAGAGCCCAGGGAGATGGAA GACTTCGCCCGAGGGGCGGCCTCCCCAGGCCCCTCCCGGCCTGGCCTGGTTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAG AACGAGCTGGAGACAAACTCAGAAGAGCAAAACAGCCAGTTCCAGAGCCTGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTC CTGCAGCACGTGGCCCTGCAGTTTGAGCCAGGACCCCTGGTTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACT AGGGCTGACCTCATCTCCGAGGATGTCCAGCGGCGGTTCGTGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAG GACTTCCGTTCCAAGCGGCTCATGGGCATGACGCCCTGGGAGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGC TACGAGGCCCGGGAGCGGCACGTGGCGGAGCGGCTGCTCATGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGT GCTGCCGTGGTCAACGCCATTGGCCTGTACATGCGCCACCTTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTC CGGAAAAAGGTGATGGGGAACCGGCGGTCGGACGAGCCTGCCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAAC CGGGGAGAGCCCCAGGTTCCAGATTTTCGACACCTCAAAGCAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTG GGGATGCCCTCTCGGGACCGGAATATCGGGGCTCCTGGGCAGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGAC CGGGAACCAGGTGCTGACGCCCCCCTGGAGCTGGGGGACTCATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGT ACCGACGAGGGGGCCGAAACCGAGAGGGAACTTTGGCGACCGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGTGACGAGGAGGAAGT GGCCTACACGGGTTAGCTGCCCAGTGAGCCATCCCGTCCCCACCACCCTCCTCCTGCCTCCTGACCCAGGACTGCTGAATACAAAGATGT TAATTTTTAAAATGTTACTAGTATAATTTATTCTATGCATTTTATAAAATAAATAAAGCTTTGACCACGACGTGCCTGAGGACAAGATCT TTTTGCTGTCGCTGCTCATGGCAGAGATGGGCGTGCACTCAGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGACA AGCGGGTCAATGACCTTTTCCGCATCATCCCAGGCATTGCTCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTGATCCTC ATGGACTGCACCGTGTCCACGGGCGCGGCGGCCATGATGGCAGTGCGCGTGCTCCTGATCACCGGTGTGTCCATTCTGCGCGCCGGTGAA ACCATGGAGCCCGCGCTGCGCGCTGTGTGCAAAGACGTGCGCATCGGCACCATCCTCATCCAGACCAACCAGCTTACCGGGGAGCCCGAG GACTGCGTCGTACAGACCCCGCAGGGGCAGGACTATGCGGGCAAGTGCTATGCGGGGAAGCAGGGACAAGGAGACCAGTCGCGACGAGTT CATCTTCTACTCCAAGAGACTGATGCGGCTGCTCATCGAGCACGCGCTCTCCTTCCTGCCCTTTCAGGGCTGCGCTGGCCTCGGCACACC >6261_6261_5_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000347545_UCKL1_chr20_62572561_ENST00000369892_length(amino acids)=357AA_BP= MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLVLRVPVPPNVAFELD RTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEE KSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATDRKG -------------------------------------------------------------- >6261_6261_6_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000347545_UCKL1_chr20_62572561_ENST00000369908_length(transcript)=1882nt_BP=1106nt CCAGGGCCCGGGATCGCCGAGCCCGACCTCGGGCGCCCCGCCGGTCACCTCCGCGCGGACACCAGCCCTGCAGAGCCCAGGGAGATGGAA GACTTCGCCCGAGGGGCGGCCTCCCCAGGCCCCTCCCGGCCTGGCCTGGTTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAG AACGAGCTGGAGACAAACTCAGAAGAGCAAAACAGCCAGTTCCAGAGCCTGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTC CTGCAGCACGTGGCCCTGCAGTTTGAGCCAGGACCCCTGGTTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACT AGGGCTGACCTCATCTCCGAGGATGTCCAGCGGCGGTTCGTGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAG GACTTCCGTTCCAAGCGGCTCATGGGCATGACGCCCTGGGAGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGC TACGAGGCCCGGGAGCGGCACGTGGCGGAGCGGCTGCTCATGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGT GCTGCCGTGGTCAACGCCATTGGCCTGTACATGCGCCACCTTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTC CGGAAAAAGGTGATGGGGAACCGGCGGTCGGACGAGCCTGCCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAAC CGGGGAGAGCCCCAGGTTCCAGATTTTCGACACCTCAAAGCAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTG GGGATGCCCTCTCGGGACCGGAATATCGGGGCTCCTGGGCAGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGAC CGGGAACCAGGTGCTGACGCCCCCCTGGAGCTGGGGGACTCATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGT ACCGACGAGGGGGCCGAAACCGAGAGGGCTGCGCTGGCCTCGGCACACCAGTGCCACCCGCTGCCCCGGACGCTGAGCGTCCTGAAGAGC ACGCCGCAGGTACGGGGCATGCACACCATCATCAGGGACAAGGAGACCAGTCGCGACGAGTTCATCTTCTACTCCAAGAGACTGATGCGG CTGCTCATCGAGCACGCGCTCTCCTTCCTGCCCTTTCAGGACTGCGTCGTACAGACCCCGCAGGGGCAGGACTATGCGGGCAAGTGCTAT GCGGGGAAGCAGATCACCGGTGTGTCCATTCTGCGCGCCGGTGAAACCATGGAGCCCGCGCTGCGCGCTGTGTGCAAAGACGTGCGCATC GGCACCATCCTCATCCAGACCAACCAGCTTACCGGGGAGCCCGAGCTCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTG ATCCTCATGGACTGCACCGTGTCCACGGGCGCGGCGGCCATGATGGCAGTGCGCGTGCTCCTGGACCACGACGTGCCTGAGGACAAGATC TTTTTGCTGTCGCTGCTCATGGCAGAGATGGGCGTGCACTCAGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGAC AAGCGGGTCAATGACCTTTTCCGCATCATCCCAGGCATTGGGAACTTTGGCGACCGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGT >6261_6261_6_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000347545_UCKL1_chr20_62572561_ENST00000369908_length(amino acids)=581AA_BP=340 MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLVLRVPVPPNVAFELD RTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEE KSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATDRKG GVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETERAALASAHQCHPLPRTLSVL KSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQDYAGKCYAGKQITGVSILRAGETMEPALRAVCKDV RIGTILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTGAAAMMAVRVLLDHDVPEDKIFLLSLLMAEMGVHSVAYAFPRVRIITTA -------------------------------------------------------------- >6261_6261_7_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000354532_UCKL1_chr20_62572561_ENST00000354216_length(transcript)=2136nt_BP=1269nt GGGGGCCTCCGGAAAAACGCCCCGACTTCCTGCCCCGCCAGAGCCAGGAAGCGGGAGCCGGGACCCAGGGCCCGGGATCGCCGAGCCCGA CCTCGGGCGCCCCGCCGGTCACCTCCGCGCGGACACCAGCCCTGCAGAGCCCAGGGAGATGGAAGACTTCGCCCGAGGGGCGGCCTCCCC AGGCCCCTCCCGGCCTGGCCTGGTTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAGAACGAGCTGGAGACAAACTCAGAAGA GCAAAACAGCCAGTTCCAGAGCCTGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTCCTGCAGCACGTGGCCCTGCAGTTTGA GCCAGGACCCCTGCTTTGCTGTCTGCATGCCGACATGCTGGGCTCACTGGGCCCCAAGGAGGCCAAGAAGGCCTTCCTGGACTTCTACCA CAGCTTCCTGGAGAAGACAGCGGTTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACTAGGGCTGACCTCATCTC CGAGGATGTCCAGCGGCGGTTCGTGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAGGACTTCCGTTCCAAGCG GCTCATGGGCATGACGCCCTGGGAGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGCTACGAGGCCCGGGAGCG GCACGTGGCGGAGCGGCTGCTCATGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGTGCTGCCGTGGTCAACGC CATTGGCCTGTACATGCGCCACCTTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTCCGGAAAAAGGTGATGGG GAACCGGCGGTCGGACGAGCCTGCCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAACCGGGGAGAGCCCCAGGT TCCAGATTTTCGACACCTCAAAGCAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTGGGGATGCCCTCTCGGGA CCGGAATATCGGGGCTCCTGGGCAGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGACCGGGAACCAGGTGCTGA CGCCCCCCTGGAGCTGGGGGACTCATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGTACCGACGAGGGGGCCGA AACCGAGAGGGCTGCGCTGGCCTCGGCACACCAGTGCCACCCGCTGCCCCGGACGCTGAGCGTCCTGAAGAGCACGCCGCAGGTACGGGG CATGCACACCATCATCAGGGACAAGGAGACCAGTCGCGACGAGTTCATCTTCTACTCCAAGAGACTGATGCGGCTGCTCATCGAGCACGC GCTCTCCTTCCTGCCCTTTCAGGACTGCGTCGTACAGACCCCGCAGGGGCAGGACTATGCGGGCAAGTGCTATGCGGGGAAGCAGATCAC CGGTGTGTCCATTCTGCGCGCCGGTGAAACCATGGAGCCCGCGCTGCGCGCTGTGTGCAAAGACGTGCGCATCGGCACCATCCTCATCCA GACCAACCAGCTTACCGGGGAGCCCGAGCTCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTGATCCTCATGGACTGCAC CGTGTCCACGGGCGCGGCGGCCATGATGGCAGTGCGCGTGCTCCTGGACCACGACGTGCCTGAGGACAAGATCTTTTTGCTGTCGCTGCT CATGGCAGAGATGGGCGTGCACTCAGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGACAAGCGGGTCAATGACCT TTTCCGCATCATCCCAGGCATTGGGAACTTTGGCGACCGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGTGACGAGGAGGAAGTGGC CTACACGGGTTAGCTGCCCAGTGAGCCATCCCGTCCCCACCACCCTCCTCCTGCCTCCTGACCCAGGACTGCTGAATACAAAGATGTTAA >6261_6261_7_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000354532_UCKL1_chr20_62572561_ENST00000354216_length(amino acids)=614AA_BP=373 MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHADMLGSLGPK EAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILD AARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL APPESTDEGAETERAALASAHQCHPLPRTLSVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQDY AGKCYAGKQITGVSILRAGETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTGAAAMMAVRVLLDHDV -------------------------------------------------------------- >6261_6261_8_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000354532_UCKL1_chr20_62572561_ENST00000369892_length(transcript)=2129nt_BP=1269nt GGGGGCCTCCGGAAAAACGCCCCGACTTCCTGCCCCGCCAGAGCCAGGAAGCGGGAGCCGGGACCCAGGGCCCGGGATCGCCGAGCCCGA CCTCGGGCGCCCCGCCGGTCACCTCCGCGCGGACACCAGCCCTGCAGAGCCCAGGGAGATGGAAGACTTCGCCCGAGGGGCGGCCTCCCC AGGCCCCTCCCGGCCTGGCCTGGTTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAGAACGAGCTGGAGACAAACTCAGAAGA GCAAAACAGCCAGTTCCAGAGCCTGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTCCTGCAGCACGTGGCCCTGCAGTTTGA GCCAGGACCCCTGCTTTGCTGTCTGCATGCCGACATGCTGGGCTCACTGGGCCCCAAGGAGGCCAAGAAGGCCTTCCTGGACTTCTACCA CAGCTTCCTGGAGAAGACAGCGGTTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACTAGGGCTGACCTCATCTC CGAGGATGTCCAGCGGCGGTTCGTGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAGGACTTCCGTTCCAAGCG GCTCATGGGCATGACGCCCTGGGAGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGCTACGAGGCCCGGGAGCG GCACGTGGCGGAGCGGCTGCTCATGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGTGCTGCCGTGGTCAACGC CATTGGCCTGTACATGCGCCACCTTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTCCGGAAAAAGGTGATGGG GAACCGGCGGTCGGACGAGCCTGCCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAACCGGGGAGAGCCCCAGGT TCCAGATTTTCGACACCTCAAAGCAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTGGGGATGCCCTCTCGGGA CCGGAATATCGGGGCTCCTGGGCAGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGACCGGGAACCAGGTGCTGA CGCCCCCCTGGAGCTGGGGGACTCATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGTACCGACGAGGGGGCCGA AACCGAGAGGGAACTTTGGCGACCGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGTGACGAGGAGGAAGTGGCCTACACGGGTTAGC TGCCCAGTGAGCCATCCCGTCCCCACCACCCTCCTCCTGCCTCCTGACCCAGGACTGCTGAATACAAAGATGTTAATTTTTAAAATGTTA CTAGTATAATTTATTCTATGCATTTTATAAAATAAATAAAGCTTTGACCACGACGTGCCTGAGGACAAGATCTTTTTGCTGTCGCTGCTC ATGGCAGAGATGGGCGTGCACTCAGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGACAAGCGGGTCAATGACCTT TTCCGCATCATCCCAGGCATTGCTCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTGATCCTCATGGACTGCACCGTGTC CACGGGCGCGGCGGCCATGATGGCAGTGCGCGTGCTCCTGATCACCGGTGTGTCCATTCTGCGCGCCGGTGAAACCATGGAGCCCGCGCT GCGCGCTGTGTGCAAAGACGTGCGCATCGGCACCATCCTCATCCAGACCAACCAGCTTACCGGGGAGCCCGAGGACTGCGTCGTACAGAC CCCGCAGGGGCAGGACTATGCGGGCAAGTGCTATGCGGGGAAGCAGGGACAAGGAGACCAGTCGCGACGAGTTCATCTTCTACTCCAAGA GACTGATGCGGCTGCTCATCGAGCACGCGCTCTCCTTCCTGCCCTTTCAGGGCTGCGCTGGCCTCGGCACACCAGTGCCACCCGCTGCCC >6261_6261_8_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000354532_UCKL1_chr20_62572561_ENST00000369892_length(amino acids)=390AA_BP= MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHADMLGSLGPK EAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILD AARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL -------------------------------------------------------------- >6261_6261_9_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000354532_UCKL1_chr20_62572561_ENST00000369908_length(transcript)=2045nt_BP=1269nt GGGGGCCTCCGGAAAAACGCCCCGACTTCCTGCCCCGCCAGAGCCAGGAAGCGGGAGCCGGGACCCAGGGCCCGGGATCGCCGAGCCCGA CCTCGGGCGCCCCGCCGGTCACCTCCGCGCGGACACCAGCCCTGCAGAGCCCAGGGAGATGGAAGACTTCGCCCGAGGGGCGGCCTCCCC AGGCCCCTCCCGGCCTGGCCTGGTTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAGAACGAGCTGGAGACAAACTCAGAAGA GCAAAACAGCCAGTTCCAGAGCCTGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTCCTGCAGCACGTGGCCCTGCAGTTTGA GCCAGGACCCCTGCTTTGCTGTCTGCATGCCGACATGCTGGGCTCACTGGGCCCCAAGGAGGCCAAGAAGGCCTTCCTGGACTTCTACCA CAGCTTCCTGGAGAAGACAGCGGTTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACTAGGGCTGACCTCATCTC CGAGGATGTCCAGCGGCGGTTCGTGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAGGACTTCCGTTCCAAGCG GCTCATGGGCATGACGCCCTGGGAGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGCTACGAGGCCCGGGAGCG GCACGTGGCGGAGCGGCTGCTCATGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGTGCTGCCGTGGTCAACGC CATTGGCCTGTACATGCGCCACCTTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTCCGGAAAAAGGTGATGGG GAACCGGCGGTCGGACGAGCCTGCCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAACCGGGGAGAGCCCCAGGT TCCAGATTTTCGACACCTCAAAGCAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTGGGGATGCCCTCTCGGGA CCGGAATATCGGGGCTCCTGGGCAGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGACCGGGAACCAGGTGCTGA CGCCCCCCTGGAGCTGGGGGACTCATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGTACCGACGAGGGGGCCGA AACCGAGAGGGCTGCGCTGGCCTCGGCACACCAGTGCCACCCGCTGCCCCGGACGCTGAGCGTCCTGAAGAGCACGCCGCAGGTACGGGG CATGCACACCATCATCAGGGACAAGGAGACCAGTCGCGACGAGTTCATCTTCTACTCCAAGAGACTGATGCGGCTGCTCATCGAGCACGC GCTCTCCTTCCTGCCCTTTCAGGACTGCGTCGTACAGACCCCGCAGGGGCAGGACTATGCGGGCAAGTGCTATGCGGGGAAGCAGATCAC CGGTGTGTCCATTCTGCGCGCCGGTGAAACCATGGAGCCCGCGCTGCGCGCTGTGTGCAAAGACGTGCGCATCGGCACCATCCTCATCCA GACCAACCAGCTTACCGGGGAGCCCGAGCTCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTGATCCTCATGGACTGCAC CGTGTCCACGGGCGCGGCGGCCATGATGGCAGTGCGCGTGCTCCTGGACCACGACGTGCCTGAGGACAAGATCTTTTTGCTGTCGCTGCT CATGGCAGAGATGGGCGTGCACTCAGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGACAAGCGGGTCAATGACCT TTTCCGCATCATCCCAGGCATTGGGAACTTTGGCGACCGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGTGACGAGGAGGAAGTGGC >6261_6261_9_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000354532_UCKL1_chr20_62572561_ENST00000369908_length(amino acids)=614AA_BP=373 MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHADMLGSLGPK EAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILD AARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL APPESTDEGAETERAALASAHQCHPLPRTLSVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQDY AGKCYAGKQITGVSILRAGETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTGAAAMMAVRVLLDHDV -------------------------------------------------------------- >6261_6261_10_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000378152_UCKL1_chr20_62572561_ENST00000354216_length(transcript)=2032nt_BP=1165nt GGGCGCAAAGGTGGACTCAGGGCGGCTAGAGCGACGCGGCGGCAGGGGTGGGGAGAGTGCGGAGCCCGAGCGCGGAGGCTTCGGTTCCGG TGGCGGCGATGGCTTCTCTTTCCACCTGGAGCAGCCCTGCAGAGCCCAGGGAGATGGAAGACTTCGCCCGAGGGGCGGCCTCCCCAGGCC CCTCCCGGCCTGGCCTGGTTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAGAACGAGCTGGAGACAAACTCAGAAGAGCAAA ACAGCCAGTTCCAGAGCCTGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTCCTGCAGCACGTGGCCCTGCAGTTTGAGCCAG GACCCCTGGTTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACTAGGGCTGACCTCATCTCCGAGGATGTCCAGC GGCGGTTCGTGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAGGACTTCCGTTCCAAGCGGCTCATGGGCATGA CGCCCTGGGAGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGCTACGAGGCCCGGGAGCGGCACGTGGCGGAGC GGCTGCTCATGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGTGCTGCCGTGGTCAACGCCATTGGCCTGTACA TGCGCCACCTTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTCCGGAAAAAGGTGATGGGGAACCGGCGGTCGG ACGAGCCTGCCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAACCGGGGAGAGCCCCAGGTTCCAGATTTTCGAC ACCTCAAAGCAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTGGGGATGCCCTCTCGGGACCGGAATATCGGGG CTCCTGGGCAGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGACCGGGAACCAGGTGCTGACGCCCCCCTGGAGC TGGGGGACTCATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGTACCGACGAGGGGGCCGAAACCGAGAGGGCTG CGCTGGCCTCGGCACACCAGTGCCACCCGCTGCCCCGGACGCTGAGCGTCCTGAAGAGCACGCCGCAGGTACGGGGCATGCACACCATCA TCAGGGACAAGGAGACCAGTCGCGACGAGTTCATCTTCTACTCCAAGAGACTGATGCGGCTGCTCATCGAGCACGCGCTCTCCTTCCTGC CCTTTCAGGACTGCGTCGTACAGACCCCGCAGGGGCAGGACTATGCGGGCAAGTGCTATGCGGGGAAGCAGATCACCGGTGTGTCCATTC TGCGCGCCGGTGAAACCATGGAGCCCGCGCTGCGCGCTGTGTGCAAAGACGTGCGCATCGGCACCATCCTCATCCAGACCAACCAGCTTA CCGGGGAGCCCGAGCTCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTGATCCTCATGGACTGCACCGTGTCCACGGGCG CGGCGGCCATGATGGCAGTGCGCGTGCTCCTGGACCACGACGTGCCTGAGGACAAGATCTTTTTGCTGTCGCTGCTCATGGCAGAGATGG GCGTGCACTCAGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGACAAGCGGGTCAATGACCTTTTCCGCATCATCC CAGGCATTGGGAACTTTGGCGACCGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGTGACGAGGAGGAAGTGGCCTACACGGGTTAGC TGCCCAGTGAGCCATCCCGTCCCCACCACCCTCCTCCTGCCTCCTGACCCAGGACTGCTGAATACAAAGATGTTAATTTTTAAAATGTTA >6261_6261_10_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000378152_UCKL1_chr20_62572561_ENST00000354216_length(amino acids)=596AA_BP=355 MASLSTWSSPAEPREMEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPL VLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLL MHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLK AEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETERAALA SAHQCHPLPRTLSVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQDYAGKCYAGKQITGVSILRA GETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTGAAAMMAVRVLLDHDVPEDKIFLLSLLMAEMGVH -------------------------------------------------------------- >6261_6261_11_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000378152_UCKL1_chr20_62572561_ENST00000369892_length(transcript)=2025nt_BP=1165nt GGGCGCAAAGGTGGACTCAGGGCGGCTAGAGCGACGCGGCGGCAGGGGTGGGGAGAGTGCGGAGCCCGAGCGCGGAGGCTTCGGTTCCGG TGGCGGCGATGGCTTCTCTTTCCACCTGGAGCAGCCCTGCAGAGCCCAGGGAGATGGAAGACTTCGCCCGAGGGGCGGCCTCCCCAGGCC CCTCCCGGCCTGGCCTGGTTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAGAACGAGCTGGAGACAAACTCAGAAGAGCAAA ACAGCCAGTTCCAGAGCCTGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTCCTGCAGCACGTGGCCCTGCAGTTTGAGCCAG GACCCCTGGTTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACTAGGGCTGACCTCATCTCCGAGGATGTCCAGC GGCGGTTCGTGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAGGACTTCCGTTCCAAGCGGCTCATGGGCATGA CGCCCTGGGAGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGCTACGAGGCCCGGGAGCGGCACGTGGCGGAGC GGCTGCTCATGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGTGCTGCCGTGGTCAACGCCATTGGCCTGTACA TGCGCCACCTTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTCCGGAAAAAGGTGATGGGGAACCGGCGGTCGG ACGAGCCTGCCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAACCGGGGAGAGCCCCAGGTTCCAGATTTTCGAC ACCTCAAAGCAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTGGGGATGCCCTCTCGGGACCGGAATATCGGGG CTCCTGGGCAGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGACCGGGAACCAGGTGCTGACGCCCCCCTGGAGC TGGGGGACTCATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGTACCGACGAGGGGGCCGAAACCGAGAGGGAAC TTTGGCGACCGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGTGACGAGGAGGAAGTGGCCTACACGGGTTAGCTGCCCAGTGAGCCA TCCCGTCCCCACCACCCTCCTCCTGCCTCCTGACCCAGGACTGCTGAATACAAAGATGTTAATTTTTAAAATGTTACTAGTATAATTTAT TCTATGCATTTTATAAAATAAATAAAGCTTTGACCACGACGTGCCTGAGGACAAGATCTTTTTGCTGTCGCTGCTCATGGCAGAGATGGG CGTGCACTCAGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGACAAGCGGGTCAATGACCTTTTCCGCATCATCCC AGGCATTGCTCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTGATCCTCATGGACTGCACCGTGTCCACGGGCGCGGCGG CCATGATGGCAGTGCGCGTGCTCCTGATCACCGGTGTGTCCATTCTGCGCGCCGGTGAAACCATGGAGCCCGCGCTGCGCGCTGTGTGCA AAGACGTGCGCATCGGCACCATCCTCATCCAGACCAACCAGCTTACCGGGGAGCCCGAGGACTGCGTCGTACAGACCCCGCAGGGGCAGG ACTATGCGGGCAAGTGCTATGCGGGGAAGCAGGGACAAGGAGACCAGTCGCGACGAGTTCATCTTCTACTCCAAGAGACTGATGCGGCTG CTCATCGAGCACGCGCTCTCCTTCCTGCCCTTTCAGGGCTGCGCTGGCCTCGGCACACCAGTGCCACCCGCTGCCCCGGACGCTGAGCGT >6261_6261_11_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000378152_UCKL1_chr20_62572561_ENST00000369892_length(amino acids)=372AA_BP= MASLSTWSSPAEPREMEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPL VLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLL MHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLK AEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETERELWR -------------------------------------------------------------- >6261_6261_12_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000378152_UCKL1_chr20_62572561_ENST00000369908_length(transcript)=1941nt_BP=1165nt GGGCGCAAAGGTGGACTCAGGGCGGCTAGAGCGACGCGGCGGCAGGGGTGGGGAGAGTGCGGAGCCCGAGCGCGGAGGCTTCGGTTCCGG TGGCGGCGATGGCTTCTCTTTCCACCTGGAGCAGCCCTGCAGAGCCCAGGGAGATGGAAGACTTCGCCCGAGGGGCGGCCTCCCCAGGCC CCTCCCGGCCTGGCCTGGTTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAGAACGAGCTGGAGACAAACTCAGAAGAGCAAA ACAGCCAGTTCCAGAGCCTGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTCCTGCAGCACGTGGCCCTGCAGTTTGAGCCAG GACCCCTGGTTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACTAGGGCTGACCTCATCTCCGAGGATGTCCAGC GGCGGTTCGTGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAGGACTTCCGTTCCAAGCGGCTCATGGGCATGA CGCCCTGGGAGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGCTACGAGGCCCGGGAGCGGCACGTGGCGGAGC GGCTGCTCATGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGTGCTGCCGTGGTCAACGCCATTGGCCTGTACA TGCGCCACCTTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTCCGGAAAAAGGTGATGGGGAACCGGCGGTCGG ACGAGCCTGCCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAACCGGGGAGAGCCCCAGGTTCCAGATTTTCGAC ACCTCAAAGCAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTGGGGATGCCCTCTCGGGACCGGAATATCGGGG CTCCTGGGCAGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGACCGGGAACCAGGTGCTGACGCCCCCCTGGAGC TGGGGGACTCATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGTACCGACGAGGGGGCCGAAACCGAGAGGGCTG CGCTGGCCTCGGCACACCAGTGCCACCCGCTGCCCCGGACGCTGAGCGTCCTGAAGAGCACGCCGCAGGTACGGGGCATGCACACCATCA TCAGGGACAAGGAGACCAGTCGCGACGAGTTCATCTTCTACTCCAAGAGACTGATGCGGCTGCTCATCGAGCACGCGCTCTCCTTCCTGC CCTTTCAGGACTGCGTCGTACAGACCCCGCAGGGGCAGGACTATGCGGGCAAGTGCTATGCGGGGAAGCAGATCACCGGTGTGTCCATTC TGCGCGCCGGTGAAACCATGGAGCCCGCGCTGCGCGCTGTGTGCAAAGACGTGCGCATCGGCACCATCCTCATCCAGACCAACCAGCTTA CCGGGGAGCCCGAGCTCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTGATCCTCATGGACTGCACCGTGTCCACGGGCG CGGCGGCCATGATGGCAGTGCGCGTGCTCCTGGACCACGACGTGCCTGAGGACAAGATCTTTTTGCTGTCGCTGCTCATGGCAGAGATGG GCGTGCACTCAGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGACAAGCGGGTCAATGACCTTTTCCGCATCATCC CAGGCATTGGGAACTTTGGCGACCGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGTGACGAGGAGGAAGTGGCCTACACGGGTTAGC >6261_6261_12_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000378152_UCKL1_chr20_62572561_ENST00000369908_length(amino acids)=596AA_BP=355 MASLSTWSSPAEPREMEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPL VLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLL MHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLK AEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETERAALA SAHQCHPLPRTLSVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQDYAGKCYAGKQITGVSILRA GETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTGAAAMMAVRVLLDHDVPEDKIFLLSLLMAEMGVH -------------------------------------------------------------- >6261_6261_13_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000599846_UCKL1_chr20_62572561_ENST00000354216_length(transcript)=2113nt_BP=1246nt GACTTCCTGCCCCGCCAGAGCCAGGAAGCGGGAGCCGGGACCCAGGGCCCGGGATCGCCGAGCCCGACCTCGGGCGCCCCGCCGGTCACC TCCGCGCGGACACCAGCCCTGCAGAGCCCAGGGAGATGGAAGACTTCGCCCGAGGGGCGGCCTCCCCAGGCCCCTCCCGGCCTGGCCTGG TTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAGAACGAGCTGGAGACAAACTCAGAAGAGCAAAACAGCCAGTTCCAGAGCC TGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTCCTGCAGCACGTGGCCCTGCAGTTTGAGCCAGGACCCCTGCTTTGCTGTC TGCATGCCGACATGCTGGGCTCACTGGGCCCCAAGGAGGCCAAGAAGGCCTTCCTGGACTTCTACCACAGCTTCCTGGAGAAGACAGCGG TTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACTAGGGCTGACCTCATCTCCGAGGATGTCCAGCGGCGGTTCG TGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAGGACTTCCGTTCCAAGCGGCTCATGGGCATGACGCCCTGGG AGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGCTACGAGGCCCGGGAGCGGCACGTGGCGGAGCGGCTGCTCA TGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGTGCTGCCGTGGTCAACGCCATTGGCCTGTACATGCGCCACC TTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTCCGGAAAAAGGTGATGGGGAACCGGCGGTCGGACGAGCCTG CCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAACCGGGGAGAGCCCCAGGTTCCAGATTTTCGACACCTCAAAG CAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTGGGGATGCCCTCTCGGGACCGGAATATCGGGGCTCCTGGGC AGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGACCGGGAACCAGGTGCTGACGCCCCCCTGGAGCTGGGGGACT CATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGTACCGACGAGGGGGCCGAAACCGAGAGGGCTGCGCTGGCCT CGGCACACCAGTGCCACCCGCTGCCCCGGACGCTGAGCGTCCTGAAGAGCACGCCGCAGGTACGGGGCATGCACACCATCATCAGGGACA AGGAGACCAGTCGCGACGAGTTCATCTTCTACTCCAAGAGACTGATGCGGCTGCTCATCGAGCACGCGCTCTCCTTCCTGCCCTTTCAGG ACTGCGTCGTACAGACCCCGCAGGGGCAGGACTATGCGGGCAAGTGCTATGCGGGGAAGCAGATCACCGGTGTGTCCATTCTGCGCGCCG GTGAAACCATGGAGCCCGCGCTGCGCGCTGTGTGCAAAGACGTGCGCATCGGCACCATCCTCATCCAGACCAACCAGCTTACCGGGGAGC CCGAGCTCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTGATCCTCATGGACTGCACCGTGTCCACGGGCGCGGCGGCCA TGATGGCAGTGCGCGTGCTCCTGGACCACGACGTGCCTGAGGACAAGATCTTTTTGCTGTCGCTGCTCATGGCAGAGATGGGCGTGCACT CAGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGACAAGCGGGTCAATGACCTTTTCCGCATCATCCCAGGCATTG GGAACTTTGGCGACCGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGTGACGAGGAGGAAGTGGCCTACACGGGTTAGCTGCCCAGTG AGCCATCCCGTCCCCACCACCCTCCTCCTGCCTCCTGACCCAGGACTGCTGAATACAAAGATGTTAATTTTTAAAATGTTACTAGTATAA >6261_6261_13_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000599846_UCKL1_chr20_62572561_ENST00000354216_length(amino acids)=614AA_BP=373 MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHADMLGSLGPK EAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILD AARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL APPESTDEGAETERAALASAHQCHPLPRTLSVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQDY AGKCYAGKQITGVSILRAGETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTGAAAMMAVRVLLDHDV -------------------------------------------------------------- >6261_6261_14_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000599846_UCKL1_chr20_62572561_ENST00000369892_length(transcript)=2106nt_BP=1246nt GACTTCCTGCCCCGCCAGAGCCAGGAAGCGGGAGCCGGGACCCAGGGCCCGGGATCGCCGAGCCCGACCTCGGGCGCCCCGCCGGTCACC TCCGCGCGGACACCAGCCCTGCAGAGCCCAGGGAGATGGAAGACTTCGCCCGAGGGGCGGCCTCCCCAGGCCCCTCCCGGCCTGGCCTGG TTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAGAACGAGCTGGAGACAAACTCAGAAGAGCAAAACAGCCAGTTCCAGAGCC TGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTCCTGCAGCACGTGGCCCTGCAGTTTGAGCCAGGACCCCTGCTTTGCTGTC TGCATGCCGACATGCTGGGCTCACTGGGCCCCAAGGAGGCCAAGAAGGCCTTCCTGGACTTCTACCACAGCTTCCTGGAGAAGACAGCGG TTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACTAGGGCTGACCTCATCTCCGAGGATGTCCAGCGGCGGTTCG TGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAGGACTTCCGTTCCAAGCGGCTCATGGGCATGACGCCCTGGG AGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGCTACGAGGCCCGGGAGCGGCACGTGGCGGAGCGGCTGCTCA TGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGTGCTGCCGTGGTCAACGCCATTGGCCTGTACATGCGCCACC TTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTCCGGAAAAAGGTGATGGGGAACCGGCGGTCGGACGAGCCTG CCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAACCGGGGAGAGCCCCAGGTTCCAGATTTTCGACACCTCAAAG CAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTGGGGATGCCCTCTCGGGACCGGAATATCGGGGCTCCTGGGC AGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGACCGGGAACCAGGTGCTGACGCCCCCCTGGAGCTGGGGGACT CATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGTACCGACGAGGGGGCCGAAACCGAGAGGGAACTTTGGCGAC CGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGTGACGAGGAGGAAGTGGCCTACACGGGTTAGCTGCCCAGTGAGCCATCCCGTCCC CACCACCCTCCTCCTGCCTCCTGACCCAGGACTGCTGAATACAAAGATGTTAATTTTTAAAATGTTACTAGTATAATTTATTCTATGCAT TTTATAAAATAAATAAAGCTTTGACCACGACGTGCCTGAGGACAAGATCTTTTTGCTGTCGCTGCTCATGGCAGAGATGGGCGTGCACTC AGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGACAAGCGGGTCAATGACCTTTTCCGCATCATCCCAGGCATTGC TCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTGATCCTCATGGACTGCACCGTGTCCACGGGCGCGGCGGCCATGATGG CAGTGCGCGTGCTCCTGATCACCGGTGTGTCCATTCTGCGCGCCGGTGAAACCATGGAGCCCGCGCTGCGCGCTGTGTGCAAAGACGTGC GCATCGGCACCATCCTCATCCAGACCAACCAGCTTACCGGGGAGCCCGAGGACTGCGTCGTACAGACCCCGCAGGGGCAGGACTATGCGG GCAAGTGCTATGCGGGGAAGCAGGGACAAGGAGACCAGTCGCGACGAGTTCATCTTCTACTCCAAGAGACTGATGCGGCTGCTCATCGAG CACGCGCTCTCCTTCCTGCCCTTTCAGGGCTGCGCTGGCCTCGGCACACCAGTGCCACCCGCTGCCCCGGACGCTGAGCGTCCTGAAGAG >6261_6261_14_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000599846_UCKL1_chr20_62572561_ENST00000369892_length(amino acids)=390AA_BP= MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHADMLGSLGPK EAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILD AARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL -------------------------------------------------------------- >6261_6261_15_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000599846_UCKL1_chr20_62572561_ENST00000369908_length(transcript)=2022nt_BP=1246nt GACTTCCTGCCCCGCCAGAGCCAGGAAGCGGGAGCCGGGACCCAGGGCCCGGGATCGCCGAGCCCGACCTCGGGCGCCCCGCCGGTCACC TCCGCGCGGACACCAGCCCTGCAGAGCCCAGGGAGATGGAAGACTTCGCCCGAGGGGCGGCCTCCCCAGGCCCCTCCCGGCCTGGCCTGG TTCCCGTCAGCATCATCGGGGCTGAGGATGAGGATTTTGAGAACGAGCTGGAGACAAACTCAGAAGAGCAAAACAGCCAGTTCCAGAGCC TGGAGCAGGTGAAGCGGCGCCCAGCCCACCTCATGGCCCTCCTGCAGCACGTGGCCCTGCAGTTTGAGCCAGGACCCCTGCTTTGCTGTC TGCATGCCGACATGCTGGGCTCACTGGGCCCCAAGGAGGCCAAGAAGGCCTTCCTGGACTTCTACCACAGCTTCCTGGAGAAGACAGCGG TTCTCCGGGTGCCGGTCCCTCCCAACGTCGCCTTTGAACTTGACCGCACTAGGGCTGACCTCATCTCCGAGGATGTCCAGCGGCGGTTCG TGCAGGAGGTGGTGCAAAGCCAGCAGGTAGCCGTGGGCCGGCAGCTGGAGGACTTCCGTTCCAAGCGGCTCATGGGCATGACGCCCTGGG AGCAGGAGCTGGCCCAGCTGGAGGCTTGGGTTGGGCGGGACCGAGCCAGCTACGAGGCCCGGGAGCGGCACGTGGCGGAGCGGCTGCTCA TGCACCTGGAGGAGATGCAACATACCATCTCTACCGACGAAGAAAAGAGTGCTGCCGTGGTCAACGCCATTGGCCTGTACATGCGCCACC TTGGGGTGCGGACCAAGAGTGGAGACAAGAAGTCGGGGAGGAACTTCTTCCGGAAAAAGGTGATGGGGAACCGGCGGTCGGACGAGCCTG CCAAGACCAAGAAGGGGCTGAGCAGCATCCTGGATGCCGCCCGCTGGAACCGGGGAGAGCCCCAGGTTCCAGATTTTCGACACCTCAAAG CAGAGGTTGATGCCGAGAAGCCAGGTGCTACAGACCGGAAGGGAGGCGTGGGGATGCCCTCTCGGGACCGGAATATCGGGGCTCCTGGGC AGGACACCCCTGGAGTCTCTCTGCACCCTCTGTCCCTGGACAGCCCAGACCGGGAACCAGGTGCTGACGCCCCCCTGGAGCTGGGGGACT CATCCCCGCAGGGCCCAATGAGCCTGGAGTCCTTGGCGCCCCCAGAGAGTACCGACGAGGGGGCCGAAACCGAGAGGGCTGCGCTGGCCT CGGCACACCAGTGCCACCCGCTGCCCCGGACGCTGAGCGTCCTGAAGAGCACGCCGCAGGTACGGGGCATGCACACCATCATCAGGGACA AGGAGACCAGTCGCGACGAGTTCATCTTCTACTCCAAGAGACTGATGCGGCTGCTCATCGAGCACGCGCTCTCCTTCCTGCCCTTTCAGG ACTGCGTCGTACAGACCCCGCAGGGGCAGGACTATGCGGGCAAGTGCTATGCGGGGAAGCAGATCACCGGTGTGTCCATTCTGCGCGCCG GTGAAACCATGGAGCCCGCGCTGCGCGCTGTGTGCAAAGACGTGCGCATCGGCACCATCCTCATCCAGACCAACCAGCTTACCGGGGAGC CCGAGCTCCACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTGATCCTCATGGACTGCACCGTGTCCACGGGCGCGGCGGCCA TGATGGCAGTGCGCGTGCTCCTGGACCACGACGTGCCTGAGGACAAGATCTTTTTGCTGTCGCTGCTCATGGCAGAGATGGGCGTGCACT CAGTGGCCTATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGACAAGCGGGTCAATGACCTTTTCCGCATCATCCCAGGCATTG GGAACTTTGGCGACCGCTACTTTGGGACAGACGCGGTCCCCGATGGCAGTGACGAGGAGGAAGTGGCCTACACGGGTTAGCTGCCCAGTG >6261_6261_15_ARHGEF1-UCKL1_ARHGEF1_chr19_42400555_ENST00000599846_UCKL1_chr20_62572561_ENST00000369908_length(amino acids)=614AA_BP=373 MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHADMLGSLGPK EAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILD AARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL APPESTDEGAETERAALASAHQCHPLPRTLSVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQDY AGKCYAGKQITGVSILRAGETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTGAAAMMAVRVLLDHDV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ARHGEF1-UCKL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARHGEF1-UCKL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARHGEF1-UCKL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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