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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PAPPA2-RPS19 (FusionGDB2 ID:62625)

Fusion Gene Summary for PAPPA2-RPS19

Fusion gene summary

Fusion gene information	Fusion gene name: PAPPA2-RPS19
	Fusion gene ID: 62625
		Hgene	Tgene
	Gene symbol	PAPPA2	RPS19
	Gene ID	60676	6223
	Gene name	pappalysin 2	ribosomal protein S19
	Synonyms	PAPP-A2\|PAPP-E\|PAPPE\|PLAC3	DBA\|DBA1\|LOH19CR1\|S19\|eS19
	Cytomap	1q25.2	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	pappalysin-2placenta-specific 3pregnancy-associated plasma preproprotein-A2pregnancy-associated plasma protein E1	40S ribosomal protein S19loss of heterozygosity on chromosome 19, region 1loss of heterozygosity, 19, chromosomal region 1small ribosomal subunit protein eS19
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000367661, ENST00000367662, ENST00000486075,	ENST00000221975, ENST00000593863, ENST00000598742,
Fusion gene scores	* DoF score	5 X 4 X 3=60	9 X 9 X 4=324
	# samples	5	10
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PAPPA2 [Title/Abstract] AND RPS19 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PAPPA2(176640251)-RPS19(42373101), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PAPPA2	GO:0006508	proteolysis	11264294
Tgene	RPS19	GO:0002548	monocyte chemotaxis	11226885
Tgene	RPS19	GO:0031640	killing of cells of other organism	15019208
Tgene	RPS19	GO:0050829	defense response to Gram-negative bacterium	15019208
Tgene	RPS19	GO:0060265	positive regulation of respiratory burst involved in inflammatory response	15750715
Tgene	RPS19	GO:0060266	negative regulation of respiratory burst involved in inflammatory response	15750715
Tgene	RPS19	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	15019208

Fusion gene breakpoints across PAPPA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RPS19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-FJ-A3Z7-01A	PAPPA2	chr1	176640251	+	RPS19	chr19	42373101	+

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Fusion Gene ORF analysis for PAPPA2-RPS19

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000367661	ENST00000221975	PAPPA2	chr1	176640251	+	RPS19	chr19	42373101	+
5CDS-5UTR	ENST00000367661	ENST00000593863	PAPPA2	chr1	176640251	+	RPS19	chr19	42373101	+
5CDS-5UTR	ENST00000367662	ENST00000221975	PAPPA2	chr1	176640251	+	RPS19	chr19	42373101	+
5CDS-5UTR	ENST00000367662	ENST00000593863	PAPPA2	chr1	176640251	+	RPS19	chr19	42373101	+
In-frame	ENST00000367661	ENST00000598742	PAPPA2	chr1	176640251	+	RPS19	chr19	42373101	+
In-frame	ENST00000367662	ENST00000598742	PAPPA2	chr1	176640251	+	RPS19	chr19	42373101	+
intron-3CDS	ENST00000486075	ENST00000598742	PAPPA2	chr1	176640251	+	RPS19	chr19	42373101	+
intron-5UTR	ENST00000486075	ENST00000221975	PAPPA2	chr1	176640251	+	RPS19	chr19	42373101	+
intron-5UTR	ENST00000486075	ENST00000593863	PAPPA2	chr1	176640251	+	RPS19	chr19	42373101	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000367661

PAPPA2

chr1

176640251

ENST00000598742

RPS19

chr19

42373101

5116

3301

1032

3566

844

ENST00000367662

PAPPA2

chr1

176640251

ENST00000598742

RPS19

chr19

42373101

5116

3301

1032

3566

844

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367661	ENST00000598742	PAPPA2	chr1	176640251	+	RPS19	chr19	42373101	+	0.00208652	0.9979134
ENST00000367662	ENST00000598742	PAPPA2	chr1	176640251	+	RPS19	chr19	42373101	+	0.00208652	0.9979134

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Fusion Genomic Features for PAPPA2-RPS19

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PAPPA2	chr1	176640251	+	RPS19	chr19	42373100	+	0.003049573	0.99695045
PAPPA2	chr1	176640251	+	RPS19	chr19	42373100	+	0.003049573	0.99695045

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PAPPA2-RPS19

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:176640251/chr19:42373101)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367661

171_174

712

828.0

Compositional bias

Note=Poly-Thr

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367662

171_174

712

1792.0

Compositional bias

Note=Poly-Thr

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367661

1654_1657

712

828.0

Compositional bias

Note=Poly-Pro

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367662

1654_1657

712

1792.0

Compositional bias

Note=Poly-Pro

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367661

1393_1461

712

828.0

Domain

Sushi 1

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367661

1462_1521

712

828.0

Domain

Sushi 2

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367661

1523_1592

712

828.0

Domain

Sushi 3

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367661

1593_1648

712

828.0

Domain

Sushi 4

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367661

1651_1731

712

828.0

Domain

Sushi 5

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367662

1393_1461

712

1792.0

Domain

Sushi 1

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367662

1462_1521

712

1792.0

Domain

Sushi 2

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367662

1523_1592

712

1792.0

Domain

Sushi 3

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367662

1593_1648

712

1792.0

Domain

Sushi 4

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367662

1651_1731

712

1792.0

Domain

Sushi 5

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367661

442_754

712

828.0

Region

Note=Metalloprotease

Hgene

PAPPA2

chr1:176640251

chr19:42373101

ENST00000367662

442_754

712

1792.0

Region

Note=Metalloprotease

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Fusion Gene Sequence for PAPPA2-RPS19

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>62625_62625_1_PAPPA2-RPS19_PAPPA2_chr1_176640251_ENST00000367661_RPS19_chr19_42373101_ENST00000598742_length(transcript)=5116nt_BP=3301nt
GGGCATGACTCTCTCTCTTGAGTAGGCACACACTCCCTTTTCTCGGGTGTGTACTTTTTGCTTTGTGATACATCTCTGCACTTTCAGTAT
TTTCCAACTCATCCTTAAATTCCTTCTCACAACAGTGTCAAGAGCCTGGACGCCAGCCAGGATTGAGGTCCTACGGGTGTTTGGGGACCT
CCCCAAGCCCACGAGTATCAATGGCAGTATCAATTGTCTGTGACAGTGATTAAGGAGCAAAACACTTGGAACCCACAAGACTCCCAGAAG
GTGAAGTTAAGAGCTCCCAGACTCATAAGGTTATTAGAACAGCAAACTGGCACCCCAAAGAACTTTACGGAGACTTGCAACCTATCAACA
AGTTGGATGAGGGATTAAAAGCCTTCAACAACCAACAACCCCAAGCATCAAACTGAAGGAAACATTCTAACCTTCACAGACAGACTGGAG
GCTGGATGGGGACCTGGCTGAAGACATCTGGAGAATGAAAGTTAAGTACCAGCTTGCATTTTTGTGCCCCTAGATTATTTTTGCATTTTA
AAATAAGAAGCATCAAATTGCGTGTCTCTGTGTAAAAGTTCTAGCAATTTGTTTTAAGGTGAACTTATTTTGGCTTAGGGACTACAAAAA
GAGAAGGTAATTCCTAGGGAAGGAAGAAGAGAAAGAAATGAAAATTAGAGAATAAGATTATTTTGAATGACTTCAGGTAGCGAGGAGTGT
GTGTTTGTGAGTGTGTATTTGAGAGACTTGGCTCATGCCTGTGGGTCTTCTCTTCTAGTATCAGTGAGGGGAGGGATTACTGAAGAAGAA
GGGGGGAAAAAAAAAGAAAGAAATCTGAGCTTTCTGGGAGGAAATTCAAAGGAACCAAGAGAAATTAACTTCGTTCTGCAAGGACTAAAG
TACAGCAAGAGGAGAGAGGTCAAGCGAGAAGCGTGCGGGAAGCACATGCCCTGGGGAGGCATAGAAGCCACACTGGCAGAGCGGCCAGCA
CAGGTAGCCAGCAGAGGCATTCTTGGGGCTATTTGAAAAAGTTTGGTCTGTGAACAAAACAGTTTCCCTGGTGACTGCAAATCCATTGCT
AGCTGCCTCTTTCTCGTCTGCCCATCACTCTGGTGTGGTACCCAGAAGTTGACTTCTGGTTCTGTAGAAAGAGCTAGGGGAGGTATGATG
TGCTTAAAGATCCTAAGAATAAGCCTGGCGATTTTGGCTGGGTGGGCACTCTGTTCTGCCAACTCTGAGCTGGGCTGGACACGCAAGAAA
TCCTTGGTTGAGAGGGAACACCTGAATCAGGTGCTGTTGGAAGGAGAACGTTGTTGGCTGGGGGCCAAGGTTCGAAGACCCAGAGCTTCT
CCACAGCATCACCTCTTTGGAGTCTACCCCAGCAGGGCTGGGAACTACCTAAGGCCCTACCCCGTGGGGGAGCAAGAAATCCATCATACA
GGACGCAGCAAACCAGACACTGAAGGAAATGCTGTGAGCCTTGTTCCCCCAGACCTGACTGAAAATCCAGCAGGACTGAGGGGTGCAGTT
GAAGAGCCGGCTGCCCCATGGGTAGGGGATAGTCCTATTGGGCAATCTGAGCTGCTGGGAGATGATGACGCTTATCTCGGCAATCAAAGA
TCCAAGGAGTCTCTAGGTGAGGCCGGGATTCAGAAAGGCTCAGCCATGGCTGCCACTACTACCACCGCCATTTTCACAACCCTGAACGAA
CCCAAACCAGAGACCCAAAGGAGGGGCTGGGCCAAGTCCAGGCAGCGTCGCCAAGTGTGGAAGAGGCGGGCGGAAGATGGGCAGGGAGAC
TCCGGTATCTCTTCACATTTCCAACCTTGGCCCAAGCATTCCCTTAAACACAGGGTCAAAAAGAGTCCACCGGAGGAAAGCAACCAAAAT
GGTGGAGAGGGCTCCTACCGAGAAGCAGAGACCTTTAACTCCCAAGTAGGACTGCCCATCTTATACTTCTCTGGGAGGCGGGAGCGGCTG
CTGCTGCGTCCAGAAGTGCTGGCTGAGATTCCCCGGGAGGCGTTCACAGTGGAAGCCTGGGTTAAACCGGAGGGAGGACAGAACAACCCA
GCCATCATCGCAGGTGTGTTTGATAACTGCTCCCACACTGTCAGTGACAAAGGCTGGGCCCTGGGGATCCGCTCAGGGAAGGACAAGGGA
AAGCGGGATGCTCGCTTCTTCTTCTCCCTCTGCACCGACCGCGTGAAGAAAGCCACCATCTTGATTAGCCACAGTCGCTACCAACCAGGC
ACATGGACCCATGTGGCAGCCACTTACGATGGACGGCACATGGCCCTGTATGTGGATGGCACTCAGGTGGCTAGCAGTCTAGACCAGTCT
GGTCCCCTGAACAGCCCCTTCATGGCATCTTGCCGCTCTTTGCTCCTGGGGGGAGACAGCTCTGAGGATGGGCACTATTTCCGTGGACAC
CTGGGCACACTGGTTTTCTGGTCGACCGCCCTGCCACAAAGCCATTTTCAGCACAGTTCTCAGCATTCAAGTGGGGAGGAGGAAGCGACT
GACTTGGTCCTGACAGCGAGCTTTGAGCCTGTGAACACAGAGTGGGTTCCCTTTAGAGATGAGAAGTACCCACGACTTGAGGTTCTCCAG
GGCTTTGAGCCAGAGCCTGAGATTCTGTCGCCTTTGCAGCCCCCACTCTGTGGGCAAACAGTCTGTGACAATGTGGAATTGATCTCCCAG
TACAATGGATACTGGCCCCTTCGGGGAGAGAAGGTGATACGCTACCAGGTGGTGAACATCTGTGATGATGAGGGCCTAAACCCCATTGTG
AGTGAGGAGCAGATTCGTCTGCAGCACGAGGCACTGAATGAGGCCTTCAGCCGCTACAACATCAGCTGGCAGCTGAGCGTCCACCAGGTC
CACAATTCCACCCTGCGACACCGGGTTGTGCTTGTGAACTGTGAGCCCAGCAAGATTGGCAATGACCATTGTGACCCCGAGTGTGAGCAC
CCACTCACAGGCTATGATGGGGGTGACTGCCGCCTGCAGGGCCGCTGCTACTCCTGGAACCGCAGGGATGGGCTCTGTCACGTGGAGTGT
AACAACATGCTGAACGACTTTGACGACGGAGACTGCTGCGACCCCCAGGTGGCTGATGTGCGCAAGACCTGCTTTGACCCTGACTCACCC
AAGAGGGCATACATGAGTGTGAAGGAGCTGAAGGAGGCCCTGCAGCTGAACAGTACTCACTTCCTCAACATCTACTTTGCCAGCTCAGTG
CGGGAAGACCTTGCAGGTGCTGCCACCTGGCCTTGGGACAAGGACGCTGTCACTCACCTGGCTTCCACAGCGCGGCACCTGTACCTCCGG
GGTGGCGCTGGGGTTGGCTCCATGACCAAGATCTATGGGGGACGTCAGAGAAACGGCGTCATGCCCAGCCACTTCAGCCGAGGCTCCAAG
AGTGTGGCCCGCCGGGTCCTCCAAGCCCTGGAGGGGCTGAAAATGGTGGAAAAGGACCAAGATGGCGGCCGCAAACTGACACCTCAGGGA
CAAAGAGATCTGGACAGAATCGCCGGACAGGTGGCAGCTGCCAACAAGAAGCATTAGAACAAACCATGCTGGGTTAATAAATTGCCTCAT
TCGTAATCCTGGTCTGGGTCTCTTTTTTGAGTCTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCCATCTCAGCTCACTGCAATCT
CCGCCTTCTGGGTTCAAATGATTCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAAGTGTGAGCCACTGTGCCTGGTCTGGTTTGGG
TCTCTTGATTGTTCTTCAGGGGCATGAGGAAGAGGCGCTTCCTCCCTTCCCTTGGGTGAGGGGGCCCAGGGTGATTGGGTGGCTGTTTAC
CCGGCAGCCAGTCGGGCCTTCCCAGGTCAAACAGTTCCCATCTGGGTTTGGAGGAAGGACCCAGGGGCCCTTGTGGCTCACTCCCCCACA
TCCTGTCTTTGCAATTGTCAGAAAGTGAGAAACGAAAGGATGGCTGTGAGCTGTGACCTCAGCTGGGCCTGGGCTGCAGAGGTGGCTTCC
GCTGGAGTAAAGCAAGAGGGCCCAGGGTTCATGCTCTTCCCTGGAAGGTAGAAAAGGACAGACCACCAGGGAGCCTCCACCGCAAACTGA
CCTGTGCTGCCTACACACTAACTTTCCTGGGCCTGGGGCCTGCACAGGCTGAATGGTCCTTGAGCCTTCACTCTGCATCTGAGCGGTCTT
GGGCCCGCTGAGTGGCAGTGGCAGGAAGTCGGTGGAAGCAGATCCCTGTGCAGAAGTTGAATTACCAGGGCGGCCACACACGGGCTGCAC
AACCTTTGCAGTCGTGCACGGCAAGTGGGATGTGGCCTCCGCCCATGATTGGGCACCTGGTCAGGCTGGGAGATCCAAATAGCACCCAGT
GGGCAGCTGTCCGACCCCTGGAGGGGCAAGCCAGGAAAGAAACTTAGGGCCCGCTGTGACCAGATGTCCCTCCCAGTTGGGAAGACTAAA
CTGGTTTGGCCAATATCTCCCAGGATTCCCCTGTCCAAATTATTCCTGGGATCTGACCCATTTCCTGGAAAGGGGCGAGCCTGGGTTTTG
AAGTTCAAACTAGAGTTTAAATCACAACTCTGCCCCTAATCCCACGTAACCCTGTGCACCTTATCCTCTGAGCCTTCGTCTCCTCGTGTG
TAAGCCTGCTAACTCCTGAGAGACTGGACAAGATGCCGTGGAGAGCCTTGGCTCTGAGTAGCTCTGCTGCTGGACAGTTCAGTTGGCAGT
CCCCAAACGTAAGGCGTAAGAGTTTAAGAAGTATCGGCCAGGCACAGTGGCTCACACCTGTAATCTCAACACTTTGGGAGGCCGAGACGG
GCTGATCACCTGAGGTTGGGAGCTTGAGAACAGCCTGACCAACATGGAGAAACCCTGTCTCTAAAAATACCAAAATTAGTTGGGCATGGT
GGCGCGCACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCGCTCGAACCCCGGAGGCGGAGGTTGCAGTGGGTTGAGATCG

>62625_62625_1_PAPPA2-RPS19_PAPPA2_chr1_176640251_ENST00000367661_RPS19_chr19_42373101_ENST00000598742_length(amino acids)=844AA_BP=756
MVCEQNSFPGDCKSIASCLFLVCPSLWCGTQKLTSGSVERARGGMMCLKILRISLAILAGWALCSANSELGWTRKKSLVEREHLNQVLLE
GERCWLGAKVRRPRASPQHHLFGVYPSRAGNYLRPYPVGEQEIHHTGRSKPDTEGNAVSLVPPDLTENPAGLRGAVEEPAAPWVGDSPIG
QSELLGDDDAYLGNQRSKESLGEAGIQKGSAMAATTTTAIFTTLNEPKPETQRRGWAKSRQRRQVWKRRAEDGQGDSGISSHFQPWPKHS
LKHRVKKSPPEESNQNGGEGSYREAETFNSQVGLPILYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQNNPAIIAGVFDNCSHTV
SDKGWALGIRSGKDKGKRDARFFFSLCTDRVKKATILISHSRYQPGTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNSPFMASCRSL
LLGGDSSEDGHYFRGHLGTLVFWSTALPQSHFQHSSQHSSGEEEATDLVLTASFEPVNTEWVPFRDEKYPRLEVLQGFEPEPEILSPLQP
PLCGQTVCDNVELISQYNGYWPLRGEKVIRYQVVNICDDEGLNPIVSEEQIRLQHEALNEAFSRYNISWQLSVHQVHNSTLRHRVVLVNC
EPSKIGNDHCDPECEHPLTGYDGGDCRLQGRCYSWNRRDGLCHVECNNMLNDFDDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEAL
QLNSTHFLNIYFASSVREDLAGAATWPWDKDAVTHLASTARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVARRVLQALEGLK

--------------------------------------------------------------
>62625_62625_2_PAPPA2-RPS19_PAPPA2_chr1_176640251_ENST00000367662_RPS19_chr19_42373101_ENST00000598742_length(transcript)=5116nt_BP=3301nt
GGGCATGACTCTCTCTCTTGAGTAGGCACACACTCCCTTTTCTCGGGTGTGTACTTTTTGCTTTGTGATACATCTCTGCACTTTCAGTAT
TTTCCAACTCATCCTTAAATTCCTTCTCACAACAGTGTCAAGAGCCTGGACGCCAGCCAGGATTGAGGTCCTACGGGTGTTTGGGGACCT
CCCCAAGCCCACGAGTATCAATGGCAGTATCAATTGTCTGTGACAGTGATTAAGGAGCAAAACACTTGGAACCCACAAGACTCCCAGAAG
GTGAAGTTAAGAGCTCCCAGACTCATAAGGTTATTAGAACAGCAAACTGGCACCCCAAAGAACTTTACGGAGACTTGCAACCTATCAACA
AGTTGGATGAGGGATTAAAAGCCTTCAACAACCAACAACCCCAAGCATCAAACTGAAGGAAACATTCTAACCTTCACAGACAGACTGGAG
GCTGGATGGGGACCTGGCTGAAGACATCTGGAGAATGAAAGTTAAGTACCAGCTTGCATTTTTGTGCCCCTAGATTATTTTTGCATTTTA
AAATAAGAAGCATCAAATTGCGTGTCTCTGTGTAAAAGTTCTAGCAATTTGTTTTAAGGTGAACTTATTTTGGCTTAGGGACTACAAAAA
GAGAAGGTAATTCCTAGGGAAGGAAGAAGAGAAAGAAATGAAAATTAGAGAATAAGATTATTTTGAATGACTTCAGGTAGCGAGGAGTGT
GTGTTTGTGAGTGTGTATTTGAGAGACTTGGCTCATGCCTGTGGGTCTTCTCTTCTAGTATCAGTGAGGGGAGGGATTACTGAAGAAGAA
GGGGGGAAAAAAAAAGAAAGAAATCTGAGCTTTCTGGGAGGAAATTCAAAGGAACCAAGAGAAATTAACTTCGTTCTGCAAGGACTAAAG
TACAGCAAGAGGAGAGAGGTCAAGCGAGAAGCGTGCGGGAAGCACATGCCCTGGGGAGGCATAGAAGCCACACTGGCAGAGCGGCCAGCA
CAGGTAGCCAGCAGAGGCATTCTTGGGGCTATTTGAAAAAGTTTGGTCTGTGAACAAAACAGTTTCCCTGGTGACTGCAAATCCATTGCT
AGCTGCCTCTTTCTCGTCTGCCCATCACTCTGGTGTGGTACCCAGAAGTTGACTTCTGGTTCTGTAGAAAGAGCTAGGGGAGGTATGATG
TGCTTAAAGATCCTAAGAATAAGCCTGGCGATTTTGGCTGGGTGGGCACTCTGTTCTGCCAACTCTGAGCTGGGCTGGACACGCAAGAAA
TCCTTGGTTGAGAGGGAACACCTGAATCAGGTGCTGTTGGAAGGAGAACGTTGTTGGCTGGGGGCCAAGGTTCGAAGACCCAGAGCTTCT
CCACAGCATCACCTCTTTGGAGTCTACCCCAGCAGGGCTGGGAACTACCTAAGGCCCTACCCCGTGGGGGAGCAAGAAATCCATCATACA
GGACGCAGCAAACCAGACACTGAAGGAAATGCTGTGAGCCTTGTTCCCCCAGACCTGACTGAAAATCCAGCAGGACTGAGGGGTGCAGTT
GAAGAGCCGGCTGCCCCATGGGTAGGGGATAGTCCTATTGGGCAATCTGAGCTGCTGGGAGATGATGACGCTTATCTCGGCAATCAAAGA
TCCAAGGAGTCTCTAGGTGAGGCCGGGATTCAGAAAGGCTCAGCCATGGCTGCCACTACTACCACCGCCATTTTCACAACCCTGAACGAA
CCCAAACCAGAGACCCAAAGGAGGGGCTGGGCCAAGTCCAGGCAGCGTCGCCAAGTGTGGAAGAGGCGGGCGGAAGATGGGCAGGGAGAC
TCCGGTATCTCTTCACATTTCCAACCTTGGCCCAAGCATTCCCTTAAACACAGGGTCAAAAAGAGTCCACCGGAGGAAAGCAACCAAAAT
GGTGGAGAGGGCTCCTACCGAGAAGCAGAGACCTTTAACTCCCAAGTAGGACTGCCCATCTTATACTTCTCTGGGAGGCGGGAGCGGCTG
CTGCTGCGTCCAGAAGTGCTGGCTGAGATTCCCCGGGAGGCGTTCACAGTGGAAGCCTGGGTTAAACCGGAGGGAGGACAGAACAACCCA
GCCATCATCGCAGGTGTGTTTGATAACTGCTCCCACACTGTCAGTGACAAAGGCTGGGCCCTGGGGATCCGCTCAGGGAAGGACAAGGGA
AAGCGGGATGCTCGCTTCTTCTTCTCCCTCTGCACCGACCGCGTGAAGAAAGCCACCATCTTGATTAGCCACAGTCGCTACCAACCAGGC
ACATGGACCCATGTGGCAGCCACTTACGATGGACGGCACATGGCCCTGTATGTGGATGGCACTCAGGTGGCTAGCAGTCTAGACCAGTCT
GGTCCCCTGAACAGCCCCTTCATGGCATCTTGCCGCTCTTTGCTCCTGGGGGGAGACAGCTCTGAGGATGGGCACTATTTCCGTGGACAC
CTGGGCACACTGGTTTTCTGGTCGACCGCCCTGCCACAAAGCCATTTTCAGCACAGTTCTCAGCATTCAAGTGGGGAGGAGGAAGCGACT
GACTTGGTCCTGACAGCGAGCTTTGAGCCTGTGAACACAGAGTGGGTTCCCTTTAGAGATGAGAAGTACCCACGACTTGAGGTTCTCCAG
GGCTTTGAGCCAGAGCCTGAGATTCTGTCGCCTTTGCAGCCCCCACTCTGTGGGCAAACAGTCTGTGACAATGTGGAATTGATCTCCCAG
TACAATGGATACTGGCCCCTTCGGGGAGAGAAGGTGATACGCTACCAGGTGGTGAACATCTGTGATGATGAGGGCCTAAACCCCATTGTG
AGTGAGGAGCAGATTCGTCTGCAGCACGAGGCACTGAATGAGGCCTTCAGCCGCTACAACATCAGCTGGCAGCTGAGCGTCCACCAGGTC
CACAATTCCACCCTGCGACACCGGGTTGTGCTTGTGAACTGTGAGCCCAGCAAGATTGGCAATGACCATTGTGACCCCGAGTGTGAGCAC
CCACTCACAGGCTATGATGGGGGTGACTGCCGCCTGCAGGGCCGCTGCTACTCCTGGAACCGCAGGGATGGGCTCTGTCACGTGGAGTGT
AACAACATGCTGAACGACTTTGACGACGGAGACTGCTGCGACCCCCAGGTGGCTGATGTGCGCAAGACCTGCTTTGACCCTGACTCACCC
AAGAGGGCATACATGAGTGTGAAGGAGCTGAAGGAGGCCCTGCAGCTGAACAGTACTCACTTCCTCAACATCTACTTTGCCAGCTCAGTG
CGGGAAGACCTTGCAGGTGCTGCCACCTGGCCTTGGGACAAGGACGCTGTCACTCACCTGGCTTCCACAGCGCGGCACCTGTACCTCCGG
GGTGGCGCTGGGGTTGGCTCCATGACCAAGATCTATGGGGGACGTCAGAGAAACGGCGTCATGCCCAGCCACTTCAGCCGAGGCTCCAAG
AGTGTGGCCCGCCGGGTCCTCCAAGCCCTGGAGGGGCTGAAAATGGTGGAAAAGGACCAAGATGGCGGCCGCAAACTGACACCTCAGGGA
CAAAGAGATCTGGACAGAATCGCCGGACAGGTGGCAGCTGCCAACAAGAAGCATTAGAACAAACCATGCTGGGTTAATAAATTGCCTCAT
TCGTAATCCTGGTCTGGGTCTCTTTTTTGAGTCTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCCATCTCAGCTCACTGCAATCT
CCGCCTTCTGGGTTCAAATGATTCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAAGTGTGAGCCACTGTGCCTGGTCTGGTTTGGG
TCTCTTGATTGTTCTTCAGGGGCATGAGGAAGAGGCGCTTCCTCCCTTCCCTTGGGTGAGGGGGCCCAGGGTGATTGGGTGGCTGTTTAC
CCGGCAGCCAGTCGGGCCTTCCCAGGTCAAACAGTTCCCATCTGGGTTTGGAGGAAGGACCCAGGGGCCCTTGTGGCTCACTCCCCCACA
TCCTGTCTTTGCAATTGTCAGAAAGTGAGAAACGAAAGGATGGCTGTGAGCTGTGACCTCAGCTGGGCCTGGGCTGCAGAGGTGGCTTCC
GCTGGAGTAAAGCAAGAGGGCCCAGGGTTCATGCTCTTCCCTGGAAGGTAGAAAAGGACAGACCACCAGGGAGCCTCCACCGCAAACTGA
CCTGTGCTGCCTACACACTAACTTTCCTGGGCCTGGGGCCTGCACAGGCTGAATGGTCCTTGAGCCTTCACTCTGCATCTGAGCGGTCTT
GGGCCCGCTGAGTGGCAGTGGCAGGAAGTCGGTGGAAGCAGATCCCTGTGCAGAAGTTGAATTACCAGGGCGGCCACACACGGGCTGCAC
AACCTTTGCAGTCGTGCACGGCAAGTGGGATGTGGCCTCCGCCCATGATTGGGCACCTGGTCAGGCTGGGAGATCCAAATAGCACCCAGT
GGGCAGCTGTCCGACCCCTGGAGGGGCAAGCCAGGAAAGAAACTTAGGGCCCGCTGTGACCAGATGTCCCTCCCAGTTGGGAAGACTAAA
CTGGTTTGGCCAATATCTCCCAGGATTCCCCTGTCCAAATTATTCCTGGGATCTGACCCATTTCCTGGAAAGGGGCGAGCCTGGGTTTTG
AAGTTCAAACTAGAGTTTAAATCACAACTCTGCCCCTAATCCCACGTAACCCTGTGCACCTTATCCTCTGAGCCTTCGTCTCCTCGTGTG
TAAGCCTGCTAACTCCTGAGAGACTGGACAAGATGCCGTGGAGAGCCTTGGCTCTGAGTAGCTCTGCTGCTGGACAGTTCAGTTGGCAGT
CCCCAAACGTAAGGCGTAAGAGTTTAAGAAGTATCGGCCAGGCACAGTGGCTCACACCTGTAATCTCAACACTTTGGGAGGCCGAGACGG
GCTGATCACCTGAGGTTGGGAGCTTGAGAACAGCCTGACCAACATGGAGAAACCCTGTCTCTAAAAATACCAAAATTAGTTGGGCATGGT
GGCGCGCACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCGCTCGAACCCCGGAGGCGGAGGTTGCAGTGGGTTGAGATCG

>62625_62625_2_PAPPA2-RPS19_PAPPA2_chr1_176640251_ENST00000367662_RPS19_chr19_42373101_ENST00000598742_length(amino acids)=844AA_BP=756
MVCEQNSFPGDCKSIASCLFLVCPSLWCGTQKLTSGSVERARGGMMCLKILRISLAILAGWALCSANSELGWTRKKSLVEREHLNQVLLE
GERCWLGAKVRRPRASPQHHLFGVYPSRAGNYLRPYPVGEQEIHHTGRSKPDTEGNAVSLVPPDLTENPAGLRGAVEEPAAPWVGDSPIG
QSELLGDDDAYLGNQRSKESLGEAGIQKGSAMAATTTTAIFTTLNEPKPETQRRGWAKSRQRRQVWKRRAEDGQGDSGISSHFQPWPKHS
LKHRVKKSPPEESNQNGGEGSYREAETFNSQVGLPILYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQNNPAIIAGVFDNCSHTV
SDKGWALGIRSGKDKGKRDARFFFSLCTDRVKKATILISHSRYQPGTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNSPFMASCRSL
LLGGDSSEDGHYFRGHLGTLVFWSTALPQSHFQHSSQHSSGEEEATDLVLTASFEPVNTEWVPFRDEKYPRLEVLQGFEPEPEILSPLQP
PLCGQTVCDNVELISQYNGYWPLRGEKVIRYQVVNICDDEGLNPIVSEEQIRLQHEALNEAFSRYNISWQLSVHQVHNSTLRHRVVLVNC
EPSKIGNDHCDPECEHPLTGYDGGDCRLQGRCYSWNRRDGLCHVECNNMLNDFDDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEAL
QLNSTHFLNIYFASSVREDLAGAATWPWDKDAVTHLASTARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVARRVLQALEGLK

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Top

Fusion Gene PPI Analysis for PAPPA2-RPS19

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PAPPA2-RPS19

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PAPPA2-RPS19

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source