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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PAPSS2-B2M (FusionGDB2 ID:62648)

Fusion Gene Summary for PAPSS2-B2M

check button Fusion gene summary
Fusion gene informationFusion gene name: PAPSS2-B2M
Fusion gene ID: 62648
HgeneTgene
Gene symbol

PAPSS2

B2M

Gene ID

9060

567

Gene name3'-phosphoadenosine 5'-phosphosulfate synthase 2beta-2-microglobulin
SynonymsATPSK2|BCYM4|SK2IMD43
Cytomap

10q23.2-q23.31

15q21.1

Type of geneprotein-codingprotein-coding
Descriptionbifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 23-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2ATP sulfurylase/APS kinase 2ATP sulfurylase/adenosine 5'-phosphosulfate kinasePAPS synthase 2PAPS synthetase 2SK 2adenosine 5'-phbeta-2-microglobulinbeta chain of MHC class I moleculesbeta-2-microglobin
Modification date2020031320200329
UniProtAcc.

P61769

Ensembl transtripts involved in fusion geneENST00000482258, ENST00000361175, 
ENST00000427144, ENST00000456849, 
ENST00000544417, ENST00000558401, 
ENST00000559916, ENST00000559220, 
Fusion gene scores* DoF score8 X 7 X 10=56064 X 31 X 17=33728
# samples 1471
** MAII scorelog2(14/560*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(71/33728*10)=-5.56998393724517
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAPSS2 [Title/Abstract] AND B2M [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPAPSS2(89469070)-B2M(45007621), # samples:1
Anticipated loss of major functional domain due to fusion event.PAPSS2-B2M seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PAPSS2-B2M seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneB2M

GO:0002726

positive regulation of T cell cytokine production

24643698

TgeneB2M

GO:0007611

learning or memory

26147761

TgeneB2M

GO:0050680

negative regulation of epithelial cell proliferation

28213472

TgeneB2M

GO:0050768

negative regulation of neurogenesis

26147761

TgeneB2M

GO:0090647

modulation of age-related behavioral decline

26147761

TgeneB2M

GO:1900121

negative regulation of receptor binding

9465039

TgeneB2M

GO:1990000

amyloid fibril formation

28468825

TgeneB2M

GO:2000774

positive regulation of cellular senescence

28213472

TgeneB2M

GO:2000978

negative regulation of forebrain neuron differentiation

26147761


check buttonFusion gene breakpoints across PAPSS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across B2M (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-A6-2678-01APAPSS2chr10

89469070

+B2Mchr15

45007621

+


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Fusion Gene ORF analysis for PAPSS2-B2M

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000482258ENST00000544417PAPSS2chr10

89469070

+B2Mchr15

45007621

+
3UTR-3CDSENST00000482258ENST00000558401PAPSS2chr10

89469070

+B2Mchr15

45007621

+
3UTR-3CDSENST00000482258ENST00000559916PAPSS2chr10

89469070

+B2Mchr15

45007621

+
3UTR-intronENST00000482258ENST00000559220PAPSS2chr10

89469070

+B2Mchr15

45007621

+
5CDS-intronENST00000361175ENST00000559220PAPSS2chr10

89469070

+B2Mchr15

45007621

+
5CDS-intronENST00000427144ENST00000559220PAPSS2chr10

89469070

+B2Mchr15

45007621

+
5CDS-intronENST00000456849ENST00000559220PAPSS2chr10

89469070

+B2Mchr15

45007621

+
Frame-shiftENST00000361175ENST00000544417PAPSS2chr10

89469070

+B2Mchr15

45007621

+
Frame-shiftENST00000427144ENST00000544417PAPSS2chr10

89469070

+B2Mchr15

45007621

+
Frame-shiftENST00000456849ENST00000544417PAPSS2chr10

89469070

+B2Mchr15

45007621

+
In-frameENST00000361175ENST00000558401PAPSS2chr10

89469070

+B2Mchr15

45007621

+
In-frameENST00000361175ENST00000559916PAPSS2chr10

89469070

+B2Mchr15

45007621

+
In-frameENST00000427144ENST00000558401PAPSS2chr10

89469070

+B2Mchr15

45007621

+
In-frameENST00000427144ENST00000559916PAPSS2chr10

89469070

+B2Mchr15

45007621

+
In-frameENST00000456849ENST00000558401PAPSS2chr10

89469070

+B2Mchr15

45007621

+
In-frameENST00000456849ENST00000559916PAPSS2chr10

89469070

+B2Mchr15

45007621

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361175PAPSS2chr1089469070+ENST00000558401B2Mchr1545007621+2092514270806178
ENST00000361175PAPSS2chr1089469070+ENST00000559916B2Mchr1545007621+1494514270806178
ENST00000456849PAPSS2chr1089469070+ENST00000558401B2Mchr1545007621+1986408164700178
ENST00000456849PAPSS2chr1089469070+ENST00000559916B2Mchr1545007621+1388408164700178
ENST00000427144PAPSS2chr1089469070+ENST00000558401B2Mchr1545007621+177319538487149
ENST00000427144PAPSS2chr1089469070+ENST00000559916B2Mchr1545007621+117519538487149

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361175ENST00000558401PAPSS2chr1089469070+B2Mchr1545007621+0.0056656350.99433434
ENST00000361175ENST00000559916PAPSS2chr1089469070+B2Mchr1545007621+0.0092983080.9907017
ENST00000456849ENST00000558401PAPSS2chr1089469070+B2Mchr1545007621+0.0071641350.9928358
ENST00000456849ENST00000559916PAPSS2chr1089469070+B2Mchr1545007621+0.0055917620.99440825
ENST00000427144ENST00000558401PAPSS2chr1089469070+B2Mchr1545007621+0.005465580.9945344
ENST00000427144ENST00000559916PAPSS2chr1089469070+B2Mchr1545007621+0.0075680740.9924319

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Fusion Genomic Features for PAPSS2-B2M


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PAPSS2chr1089469070+B2Mchr1545007620+1.22E-060.9999988
PAPSS2chr1089469070+B2Mchr1545007620+1.22E-060.9999988

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PAPSS2-B2M


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:89469070/chr15:45007621)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.B2M

P61769

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneB2Mchr10:89469070chr15:45007621ENST000005584010425_11322498.0DomainNote=Ig-like C1-type
TgeneB2Mchr10:89469070chr15:45007621ENST000005599160325_11322120.0DomainNote=Ig-like C1-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAPSS2chr10:89469070chr15:45007621ENST00000361175+212409_41248615.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89469070chr15:45007621ENST00000361175+212511_51548615.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89469070chr15:45007621ENST00000361175+21252_5748615.0Nucleotide bindingATP 1
HgenePAPSS2chr10:89469070chr15:45007621ENST00000456849+213409_41248620.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89469070chr15:45007621ENST00000456849+213511_51548620.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89469070chr15:45007621ENST00000456849+21352_5748620.0Nucleotide bindingATP 1
HgenePAPSS2chr10:89469070chr15:45007621ENST00000361175+212122_12348615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89469070chr15:45007621ENST00000361175+212174_17548615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89469070chr15:45007621ENST00000361175+2121_21548615.0RegionAdenylyl-sulfate kinase
HgenePAPSS2chr10:89469070chr15:45007621ENST00000361175+212224_61448615.0RegionSulfate adenylyltransferase
HgenePAPSS2chr10:89469070chr15:45007621ENST00000361175+21279_8248615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89469070chr15:45007621ENST00000361175+21296_9948615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89469070chr15:45007621ENST00000456849+213122_12348620.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89469070chr15:45007621ENST00000456849+213174_17548620.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89469070chr15:45007621ENST00000456849+2131_21548620.0RegionAdenylyl-sulfate kinase
HgenePAPSS2chr10:89469070chr15:45007621ENST00000456849+213224_61448620.0RegionSulfate adenylyltransferase
HgenePAPSS2chr10:89469070chr15:45007621ENST00000456849+21379_8248620.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89469070chr15:45007621ENST00000456849+21396_9948620.0RegionAdenylyl sulfate binding


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Fusion Gene Sequence for PAPSS2-B2M


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>62648_62648_1_PAPSS2-B2M_PAPSS2_chr10_89469070_ENST00000361175_B2M_chr15_45007621_ENST00000558401_length(transcript)=2092nt_BP=514nt
GGCCGCGTGCCGGGCGTGCCATCTGCCGCTCCGCTGCAAGGTCTCGCCCGGGACCGGGGCTGGCGGAGCGCGCGCCCGCGAGTAGGGGCC
GGGCCGGGGACCCCGCCTAGGCGGCGGCGGCCGGGTCCCCAAGGCTGGGCGCTGCTTGCGGAACCGACGGGGCGGAGAGGAGCGTGGCGG
GAGGAGGAGTAGGAGAAGGGGGCTGGTCAAGGGAAGTGCGACGTGTCTGCGGAGCCTTTTTATACCTCCTTCCCGGGAGTCCGGCAGCCG
CTGCTGCTGCTGCTGCTGCTGCTGCCGCCGCCGCCGCCGCCGTCCCTGCGTCCTTCGGTCTCTGCTCCCGGGACCCGGGCTCCGCCGCAG
CCAGCCAGCATGTCGGGGATCAAGAAGCAAAAGACGGAGAACCAGCAGAAATCCACCAATGTAGTCTATCAGGCCCACCATGTGAGCAGG
AATAAGAGAGGGCAAGTGGTTGGAACAAGGGGTGGGTTCCGAGGATGTACCGTGTGGCTAACAGGTACTCCAAAGATTCAGGTTTACTCA
CGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAG
AATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACC
CCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCA
GCATCATGGAGGTTTGAAGATGCCGCATTTGGATTGGATGAATTCCAAATTCTGCTTGCTTGCTTTTTAATATTGATATGCTTATACACT
TACACTTTATGCACAAAATGTAGGGTTATAATAATGTTAACATGGACATGATCTTCTTTATAATTCTACTTTGAGTGCTGTCTCCATGTT
TGATGTATCTGAGCAGGTTGCTCCACAGGTAGCTCTAGGAGGGCTGGCAACTTAGAGGTGGGGAGCAGAGAATTCTCTTATCCAACATCA
ACATCTTGGTCAGATTTGAACTCTTCAATCTCTTGCACTCAAAGCTTGTTAAGATAGTTAAGCGTGCATAAGTTAACTTCCAATTTACAT
ACTCTGCTTAGAATTTGGGGGAAAATTTAGAAATATAATTGACAGGATTATTGGAAATTTGTTATAATGAATGAAACATTTTGTCATATA
AGATTCATATTTACTTCTTATACATTTGATAAAGTAAGGCATGGTTGTGGTTAATCTGGTTTATTTTTGTTCCACAAGTTAAATAAATCA
TAAAACTTGATGTGTTATCTCTTATATCTCACTCCCACTATTACCCCTTTATTTTCAAACAGGGAAACAGTCTTCAAGTTCCACTTGGTA
AAAAATGTGAACCCCTTGTATATAGAGTTTGGCTCACAGTGTAAAGGGCCTCAGTGATTCACATTTTCCAGATTAGGAATCTGATGCTCA
AAGAAGTTAAATGGCATAGTTGGGGTGACACAGCTGTCTAGTGGGAGGCCAGCCTTCTATATTTTAGCCAGCGTTCTTTCCTGCGGGCCA
GGTCATGAGGAGTATGCAGACTCTAAGAGGGAGCAAAAGTATCTGAAGGATTTAATATTTTAGCAAGGAATAGATATACAATCATCCCTT
GGTCTCCCTGGGGGATTGGTTTCAGGACCCCTTCTTGGACACCAAATCTATGGATATTTAAGTCCCTTCTATAAAATGGTATAGTATTTG
CATATAACCTATCCACATCCTCCTGTATACTTTAAATCATTTCTAGATTACTTGTAATACCTAATACAATGTAAATGCTATGCAAATAGT
TGTTATTGTTTAAGGAATAATGACAAGAAAAAAAAGTCTGTACATGCTCAGTAAAGACACAACCATCCCTTTTTTTCCCCAGTGTTTTTG
ATCCATGGTTTGCTGAATCCACAGATGTGGAGCCCCTGGATACGGAAGGCCCGCTGTACTTTGAATGACAAATAACAGATTTAAAATTTT

>62648_62648_1_PAPSS2-B2M_PAPSS2_chr10_89469070_ENST00000361175_B2M_chr15_45007621_ENST00000558401_length(amino acids)=178AA_BP=81
MLLLLLLLPPPPPPSLRPSVSAPGTRAPPQPASMSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGTPKIQVYS

--------------------------------------------------------------
>62648_62648_2_PAPSS2-B2M_PAPSS2_chr10_89469070_ENST00000361175_B2M_chr15_45007621_ENST00000559916_length(transcript)=1494nt_BP=514nt
GGCCGCGTGCCGGGCGTGCCATCTGCCGCTCCGCTGCAAGGTCTCGCCCGGGACCGGGGCTGGCGGAGCGCGCGCCCGCGAGTAGGGGCC
GGGCCGGGGACCCCGCCTAGGCGGCGGCGGCCGGGTCCCCAAGGCTGGGCGCTGCTTGCGGAACCGACGGGGCGGAGAGGAGCGTGGCGG
GAGGAGGAGTAGGAGAAGGGGGCTGGTCAAGGGAAGTGCGACGTGTCTGCGGAGCCTTTTTATACCTCCTTCCCGGGAGTCCGGCAGCCG
CTGCTGCTGCTGCTGCTGCTGCTGCCGCCGCCGCCGCCGCCGTCCCTGCGTCCTTCGGTCTCTGCTCCCGGGACCCGGGCTCCGCCGCAG
CCAGCCAGCATGTCGGGGATCAAGAAGCAAAAGACGGAGAACCAGCAGAAATCCACCAATGTAGTCTATCAGGCCCACCATGTGAGCAGG
AATAAGAGAGGGCAAGTGGTTGGAACAAGGGGTGGGTTCCGAGGATGTACCGTGTGGCTAACAGGTACTCCAAAGATTCAGGTTTACTCA
CGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAG
AATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACC
CCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCA
GCATCATGGAGGTAAGTTTTTGACCTTGAGAAAATGTTTTTGTTTCACTGTCCTGAGGACTATTTATAGACAGCTCTAACATGATAACCC
TCACTATGTGGAGAACATTGACAGAGTAACATTTTAGCAGGGAAAGAAGAATCCTACAGGGTCATGTTCCCTTCTCCTGTGGAGTGGCAT
GAAGAAGGTGTATGGCCCCAGGTATGGCCATATTACTGACCCTCTACAGAGAGGGCAAAGGAACTGCCAGTATGGTATTGCAGGATAAAG
GCAGGTGGTTACCCACATTACCTGCAAGGCTTTGATCTTTCTTCTGCCATTTCCACATTGGACATCTCTGCTGAGGAGAGAAAATGAACC
ACTCTTTTCCTTTGTATAATGTTGTTTTATTCTTCAGACAGAAGAGAGGAGTTATACAGCTCTGCAGACATCCCATTCCTGTATGGGGAC
TGTGTTTGCCTCTTAGAGGTTCCCAGGCCACTAGAGGAGATAAAGGGAAACAGATTGTTATAACTTGATATAATGATACTATAATAGATG
TAACTACAAGGAGCTCCAGAAGCAAGAGAGAGGGAGGAACTTGGACTTCTCTGCATCTTTAGTTGGAGTCCAAAGGCTTTTCAATGAAAT

>62648_62648_2_PAPSS2-B2M_PAPSS2_chr10_89469070_ENST00000361175_B2M_chr15_45007621_ENST00000559916_length(amino acids)=178AA_BP=81
MLLLLLLLPPPPPPSLRPSVSAPGTRAPPQPASMSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGTPKIQVYS

--------------------------------------------------------------
>62648_62648_3_PAPSS2-B2M_PAPSS2_chr10_89469070_ENST00000427144_B2M_chr15_45007621_ENST00000558401_length(transcript)=1773nt_BP=195nt
GAACATTCTATCTTCAGCCACCACCCTGCAAGCCTCAGATGATTGTACTGGTTACTGAATGGGTTGACCTCTCTCTAGAGAACCAGCAGA
AATCCACCAATGTAGTCTATCAGGCCCACCATGTGAGCAGGAATAAGAGAGGGCAAGTGGTTGGAACAAGGGGTGGGTTCCGAGGATGTA
CCGTGTGGCTAACAGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGT
CTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCA
AGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGT
CACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCAGCATCATGGAGGTTTGAAGATGCCGCATTTGGATTGGATGAATTCCAAA
TTCTGCTTGCTTGCTTTTTAATATTGATATGCTTATACACTTACACTTTATGCACAAAATGTAGGGTTATAATAATGTTAACATGGACAT
GATCTTCTTTATAATTCTACTTTGAGTGCTGTCTCCATGTTTGATGTATCTGAGCAGGTTGCTCCACAGGTAGCTCTAGGAGGGCTGGCA
ACTTAGAGGTGGGGAGCAGAGAATTCTCTTATCCAACATCAACATCTTGGTCAGATTTGAACTCTTCAATCTCTTGCACTCAAAGCTTGT
TAAGATAGTTAAGCGTGCATAAGTTAACTTCCAATTTACATACTCTGCTTAGAATTTGGGGGAAAATTTAGAAATATAATTGACAGGATT
ATTGGAAATTTGTTATAATGAATGAAACATTTTGTCATATAAGATTCATATTTACTTCTTATACATTTGATAAAGTAAGGCATGGTTGTG
GTTAATCTGGTTTATTTTTGTTCCACAAGTTAAATAAATCATAAAACTTGATGTGTTATCTCTTATATCTCACTCCCACTATTACCCCTT
TATTTTCAAACAGGGAAACAGTCTTCAAGTTCCACTTGGTAAAAAATGTGAACCCCTTGTATATAGAGTTTGGCTCACAGTGTAAAGGGC
CTCAGTGATTCACATTTTCCAGATTAGGAATCTGATGCTCAAAGAAGTTAAATGGCATAGTTGGGGTGACACAGCTGTCTAGTGGGAGGC
CAGCCTTCTATATTTTAGCCAGCGTTCTTTCCTGCGGGCCAGGTCATGAGGAGTATGCAGACTCTAAGAGGGAGCAAAAGTATCTGAAGG
ATTTAATATTTTAGCAAGGAATAGATATACAATCATCCCTTGGTCTCCCTGGGGGATTGGTTTCAGGACCCCTTCTTGGACACCAAATCT
ATGGATATTTAAGTCCCTTCTATAAAATGGTATAGTATTTGCATATAACCTATCCACATCCTCCTGTATACTTTAAATCATTTCTAGATT
ACTTGTAATACCTAATACAATGTAAATGCTATGCAAATAGTTGTTATTGTTTAAGGAATAATGACAAGAAAAAAAAGTCTGTACATGCTC
AGTAAAGACACAACCATCCCTTTTTTTCCCCAGTGTTTTTGATCCATGGTTTGCTGAATCCACAGATGTGGAGCCCCTGGATACGGAAGG

>62648_62648_3_PAPSS2-B2M_PAPSS2_chr10_89469070_ENST00000427144_B2M_chr15_45007621_ENST00000558401_length(amino acids)=149AA_BP=52
MIVLVTEWVDLSLENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL

--------------------------------------------------------------
>62648_62648_4_PAPSS2-B2M_PAPSS2_chr10_89469070_ENST00000427144_B2M_chr15_45007621_ENST00000559916_length(transcript)=1175nt_BP=195nt
GAACATTCTATCTTCAGCCACCACCCTGCAAGCCTCAGATGATTGTACTGGTTACTGAATGGGTTGACCTCTCTCTAGAGAACCAGCAGA
AATCCACCAATGTAGTCTATCAGGCCCACCATGTGAGCAGGAATAAGAGAGGGCAAGTGGTTGGAACAAGGGGTGGGTTCCGAGGATGTA
CCGTGTGGCTAACAGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGT
CTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCA
AGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGT
CACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCAGCATCATGGAGGTAAGTTTTTGACCTTGAGAAAATGTTTTTGTTTCACT
GTCCTGAGGACTATTTATAGACAGCTCTAACATGATAACCCTCACTATGTGGAGAACATTGACAGAGTAACATTTTAGCAGGGAAAGAAG
AATCCTACAGGGTCATGTTCCCTTCTCCTGTGGAGTGGCATGAAGAAGGTGTATGGCCCCAGGTATGGCCATATTACTGACCCTCTACAG
AGAGGGCAAAGGAACTGCCAGTATGGTATTGCAGGATAAAGGCAGGTGGTTACCCACATTACCTGCAAGGCTTTGATCTTTCTTCTGCCA
TTTCCACATTGGACATCTCTGCTGAGGAGAGAAAATGAACCACTCTTTTCCTTTGTATAATGTTGTTTTATTCTTCAGACAGAAGAGAGG
AGTTATACAGCTCTGCAGACATCCCATTCCTGTATGGGGACTGTGTTTGCCTCTTAGAGGTTCCCAGGCCACTAGAGGAGATAAAGGGAA
ACAGATTGTTATAACTTGATATAATGATACTATAATAGATGTAACTACAAGGAGCTCCAGAAGCAAGAGAGAGGGAGGAACTTGGACTTC
TCTGCATCTTTAGTTGGAGTCCAAAGGCTTTTCAATGAAATTCTACTGCCCAGGGTACATTGATGCTGAAACCCCATTCAAATCTCCTGT

>62648_62648_4_PAPSS2-B2M_PAPSS2_chr10_89469070_ENST00000427144_B2M_chr15_45007621_ENST00000559916_length(amino acids)=149AA_BP=52
MIVLVTEWVDLSLENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL

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>62648_62648_5_PAPSS2-B2M_PAPSS2_chr10_89469070_ENST00000456849_B2M_chr15_45007621_ENST00000558401_length(transcript)=1986nt_BP=408nt
CTAGGCGGCGGCGGCCGGGTCCCCAAGGCTGGGCGCTGCTTGCGGAACCGACGGGGCGGAGAGGAGCGTGGCGGGAGGAGGAGTAGGAGA
AGGGGGCTGGTCAAGGGAAGTGCGACGTGTCTGCGGAGCCTTTTTATACCTCCTTCCCGGGAGTCCGGCAGCCGCTGCTGCTGCTGCTGC
TGCTGCTGCCGCCGCCGCCGCCGCCGTCCCTGCGTCCTTCGGTCTCTGCTCCCGGGACCCGGGCTCCGCCGCAGCCAGCCAGCATGTCGG
GGATCAAGAAGCAAAAGACGGAGAACCAGCAGAAATCCACCAATGTAGTCTATCAGGCCCACCATGTGAGCAGGAATAAGAGAGGGCAAG
TGGTTGGAACAAGGGGTGGGTTCCGAGGATGTACCGTGTGGCTAACAGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGA
ATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTG
AAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATG
AGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCAGCATCATGGAGGTTTG
AAGATGCCGCATTTGGATTGGATGAATTCCAAATTCTGCTTGCTTGCTTTTTAATATTGATATGCTTATACACTTACACTTTATGCACAA
AATGTAGGGTTATAATAATGTTAACATGGACATGATCTTCTTTATAATTCTACTTTGAGTGCTGTCTCCATGTTTGATGTATCTGAGCAG
GTTGCTCCACAGGTAGCTCTAGGAGGGCTGGCAACTTAGAGGTGGGGAGCAGAGAATTCTCTTATCCAACATCAACATCTTGGTCAGATT
TGAACTCTTCAATCTCTTGCACTCAAAGCTTGTTAAGATAGTTAAGCGTGCATAAGTTAACTTCCAATTTACATACTCTGCTTAGAATTT
GGGGGAAAATTTAGAAATATAATTGACAGGATTATTGGAAATTTGTTATAATGAATGAAACATTTTGTCATATAAGATTCATATTTACTT
CTTATACATTTGATAAAGTAAGGCATGGTTGTGGTTAATCTGGTTTATTTTTGTTCCACAAGTTAAATAAATCATAAAACTTGATGTGTT
ATCTCTTATATCTCACTCCCACTATTACCCCTTTATTTTCAAACAGGGAAACAGTCTTCAAGTTCCACTTGGTAAAAAATGTGAACCCCT
TGTATATAGAGTTTGGCTCACAGTGTAAAGGGCCTCAGTGATTCACATTTTCCAGATTAGGAATCTGATGCTCAAAGAAGTTAAATGGCA
TAGTTGGGGTGACACAGCTGTCTAGTGGGAGGCCAGCCTTCTATATTTTAGCCAGCGTTCTTTCCTGCGGGCCAGGTCATGAGGAGTATG
CAGACTCTAAGAGGGAGCAAAAGTATCTGAAGGATTTAATATTTTAGCAAGGAATAGATATACAATCATCCCTTGGTCTCCCTGGGGGAT
TGGTTTCAGGACCCCTTCTTGGACACCAAATCTATGGATATTTAAGTCCCTTCTATAAAATGGTATAGTATTTGCATATAACCTATCCAC
ATCCTCCTGTATACTTTAAATCATTTCTAGATTACTTGTAATACCTAATACAATGTAAATGCTATGCAAATAGTTGTTATTGTTTAAGGA
ATAATGACAAGAAAAAAAAGTCTGTACATGCTCAGTAAAGACACAACCATCCCTTTTTTTCCCCAGTGTTTTTGATCCATGGTTTGCTGA
ATCCACAGATGTGGAGCCCCTGGATACGGAAGGCCCGCTGTACTTTGAATGACAAATAACAGATTTAAAATTTTCAAGGCATAGTTTTAT

>62648_62648_5_PAPSS2-B2M_PAPSS2_chr10_89469070_ENST00000456849_B2M_chr15_45007621_ENST00000558401_length(amino acids)=178AA_BP=81
MLLLLLLLPPPPPPSLRPSVSAPGTRAPPQPASMSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGTPKIQVYS

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>62648_62648_6_PAPSS2-B2M_PAPSS2_chr10_89469070_ENST00000456849_B2M_chr15_45007621_ENST00000559916_length(transcript)=1388nt_BP=408nt
CTAGGCGGCGGCGGCCGGGTCCCCAAGGCTGGGCGCTGCTTGCGGAACCGACGGGGCGGAGAGGAGCGTGGCGGGAGGAGGAGTAGGAGA
AGGGGGCTGGTCAAGGGAAGTGCGACGTGTCTGCGGAGCCTTTTTATACCTCCTTCCCGGGAGTCCGGCAGCCGCTGCTGCTGCTGCTGC
TGCTGCTGCCGCCGCCGCCGCCGCCGTCCCTGCGTCCTTCGGTCTCTGCTCCCGGGACCCGGGCTCCGCCGCAGCCAGCCAGCATGTCGG
GGATCAAGAAGCAAAAGACGGAGAACCAGCAGAAATCCACCAATGTAGTCTATCAGGCCCACCATGTGAGCAGGAATAAGAGAGGGCAAG
TGGTTGGAACAAGGGGTGGGTTCCGAGGATGTACCGTGTGGCTAACAGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGA
ATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTG
AAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATG
AGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCAGCATCATGGAGGTAAG
TTTTTGACCTTGAGAAAATGTTTTTGTTTCACTGTCCTGAGGACTATTTATAGACAGCTCTAACATGATAACCCTCACTATGTGGAGAAC
ATTGACAGAGTAACATTTTAGCAGGGAAAGAAGAATCCTACAGGGTCATGTTCCCTTCTCCTGTGGAGTGGCATGAAGAAGGTGTATGGC
CCCAGGTATGGCCATATTACTGACCCTCTACAGAGAGGGCAAAGGAACTGCCAGTATGGTATTGCAGGATAAAGGCAGGTGGTTACCCAC
ATTACCTGCAAGGCTTTGATCTTTCTTCTGCCATTTCCACATTGGACATCTCTGCTGAGGAGAGAAAATGAACCACTCTTTTCCTTTGTA
TAATGTTGTTTTATTCTTCAGACAGAAGAGAGGAGTTATACAGCTCTGCAGACATCCCATTCCTGTATGGGGACTGTGTTTGCCTCTTAG
AGGTTCCCAGGCCACTAGAGGAGATAAAGGGAAACAGATTGTTATAACTTGATATAATGATACTATAATAGATGTAACTACAAGGAGCTC
CAGAAGCAAGAGAGAGGGAGGAACTTGGACTTCTCTGCATCTTTAGTTGGAGTCCAAAGGCTTTTCAATGAAATTCTACTGCCCAGGGTA

>62648_62648_6_PAPSS2-B2M_PAPSS2_chr10_89469070_ENST00000456849_B2M_chr15_45007621_ENST00000559916_length(amino acids)=178AA_BP=81
MLLLLLLLPPPPPPSLRPSVSAPGTRAPPQPASMSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGTPKIQVYS

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Fusion Gene PPI Analysis for PAPSS2-B2M


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PAPSS2-B2M


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PAPSS2-B2M


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource