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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PAPSS2-BID (FusionGDB2 ID:62649)

Fusion Gene Summary for PAPSS2-BID

check button Fusion gene summary
Fusion gene informationFusion gene name: PAPSS2-BID
Fusion gene ID: 62649
HgeneTgene
Gene symbol

PAPSS2

BID

Gene ID

9060

637

Gene name3'-phosphoadenosine 5'-phosphosulfate synthase 2BH3 interacting domain death agonist
SynonymsATPSK2|BCYM4|SK2FP497
Cytomap

10q23.2-q23.31

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionbifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 23-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2ATP sulfurylase/APS kinase 2ATP sulfurylase/adenosine 5'-phosphosulfate kinasePAPS synthase 2PAPS synthetase 2SK 2adenosine 5'-phBH3-interacting domain death agonistBH3 interacting domain death agonist Si6 isoformBID isoform ES(1b)BID isoform L(2)BID isoform Si6Human BID coding sequenceapoptic death agonistdesmocollin type 4p22 BID
Modification date2020031320200313
UniProtAcc.

P55957

Ensembl transtripts involved in fusion geneENST00000482258, ENST00000361175, 
ENST00000427144, ENST00000456849, 
ENST00000317361, ENST00000342111, 
ENST00000399765, ENST00000399767, 
ENST00000399774, ENST00000473439, 
ENST00000551952, 
Fusion gene scores* DoF score8 X 7 X 10=5608 X 6 X 7=336
# samples 149
** MAII scorelog2(14/560*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAPSS2 [Title/Abstract] AND BID [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPAPSS2(89469070)-BID(18222254), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBID

GO:0001836

release of cytochrome c from mitochondria

17052454

TgeneBID

GO:0031334

positive regulation of protein complex assembly

19074440|21041309

TgeneBID

GO:0090150

establishment of protein localization to membrane

21041309


check buttonFusion gene breakpoints across PAPSS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BID (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-A5GH-01APAPSS2chr10

89469070

-BIDchr22

18222254

-
ChimerDB4LUSCTCGA-77-A5GH-01APAPSS2chr10

89469070

+BIDchr22

18222254

-
ChimerDB4LUSCTCGA-77-A5GHPAPSS2chr10

89469070

+BIDchr22

18222254

-


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Fusion Gene ORF analysis for PAPSS2-BID

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000482258ENST00000317361PAPSS2chr10

89469070

+BIDchr22

18222254

-
3UTR-5UTRENST00000482258ENST00000342111PAPSS2chr10

89469070

+BIDchr22

18222254

-
3UTR-5UTRENST00000482258ENST00000399765PAPSS2chr10

89469070

+BIDchr22

18222254

-
3UTR-5UTRENST00000482258ENST00000399767PAPSS2chr10

89469070

+BIDchr22

18222254

-
3UTR-5UTRENST00000482258ENST00000399774PAPSS2chr10

89469070

+BIDchr22

18222254

-
3UTR-5UTRENST00000482258ENST00000473439PAPSS2chr10

89469070

+BIDchr22

18222254

-
3UTR-5UTRENST00000482258ENST00000551952PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000361175ENST00000342111PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000361175ENST00000399765PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000361175ENST00000399767PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000361175ENST00000399774PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000361175ENST00000473439PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000361175ENST00000551952PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000427144ENST00000342111PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000427144ENST00000399765PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000427144ENST00000399767PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000427144ENST00000399774PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000427144ENST00000473439PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000427144ENST00000551952PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000456849ENST00000342111PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000456849ENST00000399765PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000456849ENST00000399767PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000456849ENST00000399774PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000456849ENST00000473439PAPSS2chr10

89469070

+BIDchr22

18222254

-
5CDS-5UTRENST00000456849ENST00000551952PAPSS2chr10

89469070

+BIDchr22

18222254

-
In-frameENST00000361175ENST00000317361PAPSS2chr10

89469070

+BIDchr22

18222254

-
In-frameENST00000427144ENST00000317361PAPSS2chr10

89469070

+BIDchr22

18222254

-
In-frameENST00000456849ENST00000317361PAPSS2chr10

89469070

+BIDchr22

18222254

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361175PAPSS2chr1089469070+ENST00000317361BIDchr2218222254-2319514270878202
ENST00000456849PAPSS2chr1089469070+ENST00000317361BIDchr2218222254-2213408164772202
ENST00000427144PAPSS2chr1089469070+ENST00000317361BIDchr2218222254-200019538559173

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361175ENST00000317361PAPSS2chr1089469070+BIDchr2218222254-0.0041034850.9958966
ENST00000456849ENST00000317361PAPSS2chr1089469070+BIDchr2218222254-0.0041192610.9958807
ENST00000427144ENST00000317361PAPSS2chr1089469070+BIDchr2218222254-0.003540750.9964592

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Fusion Genomic Features for PAPSS2-BID


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PAPSS2-BID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:89469070/chr22:18222254)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BID

P55957

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:14583606}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBIDchr10:89469070chr22:18222254ENST000003997650486_1000100.0MotifBH3
TgeneBIDchr10:89469070chr22:18222254ENST000003997671586_1000100.0MotifBH3
TgeneBIDchr10:89469070chr22:18222254ENST000003997742686_10074196.0MotifBH3
TgeneBIDchr10:89469070chr22:18222254ENST000005519522686_10074196.0MotifBH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAPSS2chr10:89469070chr22:18222254ENST00000361175+212409_41248615.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89469070chr22:18222254ENST00000361175+212511_51548615.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89469070chr22:18222254ENST00000361175+21252_5748615.0Nucleotide bindingATP 1
HgenePAPSS2chr10:89469070chr22:18222254ENST00000456849+213409_41248620.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89469070chr22:18222254ENST00000456849+213511_51548620.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89469070chr22:18222254ENST00000456849+21352_5748620.0Nucleotide bindingATP 1
HgenePAPSS2chr10:89469070chr22:18222254ENST00000361175+212122_12348615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89469070chr22:18222254ENST00000361175+212174_17548615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89469070chr22:18222254ENST00000361175+2121_21548615.0RegionAdenylyl-sulfate kinase
HgenePAPSS2chr10:89469070chr22:18222254ENST00000361175+212224_61448615.0RegionSulfate adenylyltransferase
HgenePAPSS2chr10:89469070chr22:18222254ENST00000361175+21279_8248615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89469070chr22:18222254ENST00000361175+21296_9948615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89469070chr22:18222254ENST00000456849+213122_12348620.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89469070chr22:18222254ENST00000456849+213174_17548620.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89469070chr22:18222254ENST00000456849+2131_21548620.0RegionAdenylyl-sulfate kinase
HgenePAPSS2chr10:89469070chr22:18222254ENST00000456849+213224_61448620.0RegionSulfate adenylyltransferase
HgenePAPSS2chr10:89469070chr22:18222254ENST00000456849+21379_8248620.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89469070chr22:18222254ENST00000456849+21396_9948620.0RegionAdenylyl sulfate binding
TgeneBIDchr10:89469070chr22:18222254ENST000003173612686_100120242.0MotifBH3
TgeneBIDchr10:89469070chr22:18222254ENST000003421113786_100106182.33333333333334MotifBH3


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Fusion Gene Sequence for PAPSS2-BID


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>62649_62649_1_PAPSS2-BID_PAPSS2_chr10_89469070_ENST00000361175_BID_chr22_18222254_ENST00000317361_length(transcript)=2319nt_BP=514nt
GGCCGCGTGCCGGGCGTGCCATCTGCCGCTCCGCTGCAAGGTCTCGCCCGGGACCGGGGCTGGCGGAGCGCGCGCCCGCGAGTAGGGGCC
GGGCCGGGGACCCCGCCTAGGCGGCGGCGGCCGGGTCCCCAAGGCTGGGCGCTGCTTGCGGAACCGACGGGGCGGAGAGGAGCGTGGCGG
GAGGAGGAGTAGGAGAAGGGGGCTGGTCAAGGGAAGTGCGACGTGTCTGCGGAGCCTTTTTATACCTCCTTCCCGGGAGTCCGGCAGCCG
CTGCTGCTGCTGCTGCTGCTGCTGCCGCCGCCGCCGCCGCCGTCCCTGCGTCCTTCGGTCTCTGCTCCCGGGACCCGGGCTCCGCCGCAG
CCAGCCAGCATGTCGGGGATCAAGAAGCAAAAGACGGAGAACCAGCAGAAATCCACCAATGTAGTCTATCAGGCCCACCATGTGAGCAGG
AATAAGAGAGGGCAAGTGGTTGGAACAAGGGGTGGGTTCCGAGGATGTACCGTGTGGCTAACAGATTCTGAAAGTCAAGAAGACATCATC
CGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCTC
AGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGGAG
AAGGAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACA
ACAGTGAATTTTATTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTG
ACTGGCTAAAGCTCGATGTGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACA
GGCTGGAAGATAGCTGTGACTTCTATTTTAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAA
ATGTCCATTTACACGTATTTGAATGGCCTTCATATCATCCACACATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCA
CTGTGCAGGTTCCCACTTAAAAATTAAATTGGAAAGCAGGTTTCAAGGAAGTAGAAACAAAATACAATTTTTTTGGTAAAAAAAAATTAC
TGTTTATTAAAGTACAACCATAGAGGATGGTCTTACAGCAGGCAGTATCCTGTTTGAGGAAAGCAAGAATCAGAGAAGGAACATACCCCT
TACAAATGAAAAATTCCACTCAAAATAGGGACTATCTATCTTAATACTAAGGAACCAACAATCTTCCTGTTTAAAAAACCACATGGCACA
GAGATTCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCCCAGTACACAGGGGCTTGACTTTTTCAACTTCGTTTCCTTTGT
TGGAGTCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTCAGCCACTGTTTGTTTACAAAATCAGGTA
ACTAACTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTGCCAGAAGCTACTGCGATGCCCC
GGGAGTTAGCCCCCTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCTCAGAAGTGCATCTGGAGAGAA
CAGGTTTCTAAGCATAAAAGATGAAAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAA
GTCACTTAGGTAGTACCAAAATAAATAAGGAAAAGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTC
CCAGGAATCAGTTTAAAAGCACGACAGTGGATGCTGGGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGA
GGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATC
ATCAGAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACA

>62649_62649_1_PAPSS2-BID_PAPSS2_chr10_89469070_ENST00000361175_BID_chr22_18222254_ENST00000317361_length(amino acids)=202AA_BP=80
MLLLLLLLPPPPPPSLRPSVSAPGTRAPPQPASMSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTDSESQEDII
RNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHT

--------------------------------------------------------------
>62649_62649_2_PAPSS2-BID_PAPSS2_chr10_89469070_ENST00000427144_BID_chr22_18222254_ENST00000317361_length(transcript)=2000nt_BP=195nt
GAACATTCTATCTTCAGCCACCACCCTGCAAGCCTCAGATGATTGTACTGGTTACTGAATGGGTTGACCTCTCTCTAGAGAACCAGCAGA
AATCCACCAATGTAGTCTATCAGGCCCACCATGTGAGCAGGAATAAGAGAGGGCAAGTGGTTGGAACAAGGGGTGGGTTCCGAGGATGTA
CCGTGTGGCTAACAGATTCTGAAAGTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTA
GCATCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCTCAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTG
CCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGGAGAAGGAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGG
CCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAATTTTATTAACCAGAACCTACGCACCTACGTGAGGAGCTTAG
CCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATGTGGTCACAGCTGTATAGCTGCTTCCAGTGTA
GACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTTTAAAGACAATGTTAAACTTAT
AACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATTTACACGTATTTGAATGGCCTTCATATCATCCACACATGAA
TCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCACTTAAAAATTAAATTGGAAAGCAGGTTTCAAGGA
AGTAGAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACAACCATAGAGGATGGTCTTACAGCAGGCAGTATC
CTGTTTGAGGAAAGCAAGAATCAGAGAAGGAACATACCCCTTACAAATGAAAAATTCCACTCAAAATAGGGACTATCTATCTTAATACTA
AGGAACCAACAATCTTCCTGTTTAAAAAACCACATGGCACAGAGATTCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCCC
AGTACACAGGGGCTTGACTTTTTCAACTTCGTTTCCTTTGTTGGAGTCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTT
AAGGGCCCAGGTCAGCCACTGTTTGTTTACAAAATCAGGTAACTAACTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAA
AGACATGAAGCCACGGGTGCCAGAAGCTACTGCGATGCCCCGGGAGTTAGCCCCCTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATA
CGCTCAGCTCATCCATGCCTCAGAAGTGCATCTGGAGAGAACAGGTTTCTAAGCATAAAAGATGAAAGAGCAGTTGGACTTTTTAAAAAT
TCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAAGTCACTTAGGTAGTACCAAAATAAATAAGGAAAAGCTTAGCTTTAGAAA
CAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGGAATCAGTTTAAAAGCACGACAGTGGATGCTGGGTCCATATCACA
CACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTC
TTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCAGAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACC
ACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAA

>62649_62649_2_PAPSS2-BID_PAPSS2_chr10_89469070_ENST00000427144_BID_chr22_18222254_ENST00000317361_length(amino acids)=173AA_BP=51
MIVLVTEWVDLSLENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTDSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQ

--------------------------------------------------------------
>62649_62649_3_PAPSS2-BID_PAPSS2_chr10_89469070_ENST00000456849_BID_chr22_18222254_ENST00000317361_length(transcript)=2213nt_BP=408nt
CTAGGCGGCGGCGGCCGGGTCCCCAAGGCTGGGCGCTGCTTGCGGAACCGACGGGGCGGAGAGGAGCGTGGCGGGAGGAGGAGTAGGAGA
AGGGGGCTGGTCAAGGGAAGTGCGACGTGTCTGCGGAGCCTTTTTATACCTCCTTCCCGGGAGTCCGGCAGCCGCTGCTGCTGCTGCTGC
TGCTGCTGCCGCCGCCGCCGCCGCCGTCCCTGCGTCCTTCGGTCTCTGCTCCCGGGACCCGGGCTCCGCCGCAGCCAGCCAGCATGTCGG
GGATCAAGAAGCAAAAGACGGAGAACCAGCAGAAATCCACCAATGTAGTCTATCAGGCCCACCATGTGAGCAGGAATAAGAGAGGGCAAG
TGGTTGGAACAAGGGGTGGGTTCCGAGGATGTACCGTGTGGCTAACAGATTCTGAAAGTCAAGAAGACATCATCCGGAATATTGCCAGGC
ACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCTCAGGAACACCAGCCGGT
CGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGGAGAAGGAGAAGACCATGC
TGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAATTTTATTA
ACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGA
TGTGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTG
TGACTTCTATTTTAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATTTACACGT
ATTTGAATGGCCTTCATATCATCCACACATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCAC
TTAAAAATTAAATTGGAAAGCAGGTTTCAAGGAAGTAGAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACA
ACCATAGAGGATGGTCTTACAGCAGGCAGTATCCTGTTTGAGGAAAGCAAGAATCAGAGAAGGAACATACCCCTTACAAATGAAAAATTC
CACTCAAAATAGGGACTATCTATCTTAATACTAAGGAACCAACAATCTTCCTGTTTAAAAAACCACATGGCACAGAGATTCTGAACTAAA
GTGCTGCACTCAAATGATGGGAAGTCCGGCCCCAGTACACAGGGGCTTGACTTTTTCAACTTCGTTTCCTTTGTTGGAGTCAAAAAGAAC
CACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTCAGCCACTGTTTGTTTACAAAATCAGGTAACTAACTGCATACACT
TTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTGCCAGAAGCTACTGCGATGCCCCGGGAGTTAGCCCCCTG
GTAATAGCTGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCTCAGAAGTGCATCTGGAGAGAACAGGTTTCTAAGCATA
AAAGATGAAAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAAGTCACTTAGGTAGTAC
CAAAATAAATAAGGAAAAGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGGAATCAGTTTAA
AAGCACGACAGTGGATGCTGGGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCACTGGAGACGCA
TATGAGTAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCAGAAAGGAAAAAC
AAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAAGT

>62649_62649_3_PAPSS2-BID_PAPSS2_chr10_89469070_ENST00000456849_BID_chr22_18222254_ENST00000317361_length(amino acids)=202AA_BP=80
MLLLLLLLPPPPPPSLRPSVSAPGTRAPPQPASMSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTDSESQEDII
RNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHT

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Fusion Gene PPI Analysis for PAPSS2-BID


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PAPSS2-BID


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PAPSS2-BID


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource