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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGEF25-NTRK1 (FusionGDB2 ID:6265)

Fusion Gene Summary for ARHGEF25-NTRK1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF25-NTRK1
Fusion gene ID: 6265
HgeneTgene
Gene symbol

ARHGEF25

NTRK1

Gene ID

115557

4914

Gene nameRho guanine nucleotide exchange factor 25neurotrophic receptor tyrosine kinase 1
SynonymsGEFT|p63RhoGEFMTC|TRK|TRK1|TRKA|Trk-A|p140-TrkA
Cytomap

12q13.3

1q23.1

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 25RAC/CDC42 exchange factorRho guanine nucleotide exchange factor (GEF) 25RhoA/RAC/CDC42 exchange factorguanine nucleotide exchange factor GEFTrac/Cdc42/Rho exchange factor GEFTrhoA/Rac/Cdc42 guanine nucleotidehigh affinity nerve growth factor receptorOncogene TRKTRK1-transforming tyrosine kinase proteingp140trkneurotrophic tyrosine kinase, receptor, type 1tropomyosin-related kinase Atyrosine kinase receptor A
Modification date2020031320200313
UniProtAcc

Q86VW2

P04629

Ensembl transtripts involved in fusion geneENST00000286494, ENST00000333972, 
ENST00000477314, 		ENST00000531606, 
ENST00000358660, ENST00000368196, 
ENST00000392302, ENST00000524377, 
Fusion gene scores* DoF score3 X 3 X 2=1825 X 24 X 13=7800
# samples 333
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(33/7800*10)=-4.56293619439116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGEF25 [Title/Abstract] AND NTRK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF25(58008800)-NTRK1(156841415), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNTRK1

GO:0006468

protein phosphorylation

15488758

TgeneNTRK1

GO:0008285

negative regulation of cell proliferation

15488758

TgeneNTRK1

GO:0010976

positive regulation of neuron projection development

15488758

TgeneNTRK1

GO:0018108

peptidyl-tyrosine phosphorylation

2927393

TgeneNTRK1

GO:0043547

positive regulation of GTPase activity

15488758

TgeneNTRK1

GO:0046579

positive regulation of Ras protein signal transduction

15488758

TgeneNTRK1

GO:0046777

protein autophosphorylation

15488758

TgeneNTRK1

GO:0048011

neurotrophin TRK receptor signaling pathway

15488758

TgeneNTRK1

GO:0051092

positive regulation of NF-kappaB transcription factor activity

15488758

TgeneNTRK1

GO:0070374

positive regulation of ERK1 and ERK2 cascade

15488758

TgeneNTRK1

GO:1904646

cellular response to amyloid-beta

11927634


check buttonFusion gene breakpoints across ARHGEF25 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NTRK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A7EI-01AARHGEF25chr12

58008800

+NTRK1chr1

156841415

+


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Fusion Gene ORF analysis for ARHGEF25-NTRK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000286494ENST00000531606ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+
5CDS-intronENST00000333972ENST00000531606ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+
In-frameENST00000286494ENST00000358660ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+
In-frameENST00000286494ENST00000368196ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+
In-frameENST00000286494ENST00000392302ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+
In-frameENST00000286494ENST00000524377ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+
In-frameENST00000333972ENST00000358660ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+
In-frameENST00000333972ENST00000368196ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+
In-frameENST00000333972ENST00000392302ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+
In-frameENST00000333972ENST00000524377ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+
intron-3CDSENST00000477314ENST00000358660ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+
intron-3CDSENST00000477314ENST00000368196ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+
intron-3CDSENST00000477314ENST00000392302ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+
intron-3CDSENST00000477314ENST00000524377ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+
intron-intronENST00000477314ENST00000531606ARHGEF25chr12

58008800

+NTRK1chr1

156841415

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000333972ARHGEF25chr1258008800+ENST00000392302NTRK1chr1156841415+2922111472769920
ENST00000333972ARHGEF25chr1258008800+ENST00000368196NTRK1chr1156841415+2978111472769920
ENST00000333972ARHGEF25chr1258008800+ENST00000524377NTRK1chr1156841415+2788111472787927
ENST00000333972ARHGEF25chr1258008800+ENST00000358660NTRK1chr1156841415+2848111472778923
ENST00000286494ARHGEF25chr1258008800+ENST00000392302NTRK1chr1156841415+322814204153075886
ENST00000286494ARHGEF25chr1258008800+ENST00000368196NTRK1chr1156841415+328414204153075886
ENST00000286494ARHGEF25chr1258008800+ENST00000524377NTRK1chr1156841415+309414204153093893
ENST00000286494ARHGEF25chr1258008800+ENST00000358660NTRK1chr1156841415+315414204153084889

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000333972ENST00000392302ARHGEF25chr1258008800+NTRK1chr1156841415+0.004925520.99507445
ENST00000333972ENST00000368196ARHGEF25chr1258008800+NTRK1chr1156841415+0.0047250050.995275
ENST00000333972ENST00000524377ARHGEF25chr1258008800+NTRK1chr1156841415+0.0054535850.9945464
ENST00000333972ENST00000358660ARHGEF25chr1258008800+NTRK1chr1156841415+0.0053105780.99468946
ENST00000286494ENST00000392302ARHGEF25chr1258008800+NTRK1chr1156841415+0.0046862020.99531376
ENST00000286494ENST00000368196ARHGEF25chr1258008800+NTRK1chr1156841415+0.0044597290.9955402
ENST00000286494ENST00000524377ARHGEF25chr1258008800+NTRK1chr1156841415+0.0049716550.9950283
ENST00000286494ENST00000358660ARHGEF25chr1258008800+NTRK1chr1156841415+0.005161640.9948383

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Fusion Genomic Features for ARHGEF25-NTRK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGEF25chr1258008800+NTRK1chr1156841414+1.31E-050.9999869
ARHGEF25chr1258008800+NTRK1chr1156841414+1.31E-050.9999869

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGEF25-NTRK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:58008800/chr1:156841415)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGEF25

Q86VW2

NTRK1

P04629

FUNCTION: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:11861769, ECO:0000269|PubMed:12547822, ECO:0000269|PubMed:15069594, ECO:0000269|PubMed:15632174, ECO:0000269|PubMed:16314529, ECO:0000269|PubMed:17606614}.FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:22649032, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. {ECO:0000250|UniProtKB:P35739, ECO:0000250|UniProtKB:Q3UFB7, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:1281417, ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:17196528, ECO:0000269|PubMed:1849459, ECO:0000269|PubMed:1850821, ECO:0000269|PubMed:22649032, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27676246, ECO:0000269|PubMed:8155326, ECO:0000269|PubMed:8325889}.; FUNCTION: [Isoform TrkA-III]: Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. {ECO:0000269|PubMed:15488758}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF25chr12:58008800chr1:156841415ENST00000333972+1116160_336359620.0DomainDH
HgeneARHGEF25chr12:58008800chr1:156841415ENST00000286494+1015278_299320581.0RegionNote=Important for binding to Rho GTPases
HgeneARHGEF25chr12:58008800chr1:156841415ENST00000333972+1116278_299359620.0RegionNote=Important for binding to Rho GTPases
TgeneNTRK1chr12:58008800chr1:156841415ENST00000368196516299_365239791.0DomainIg-like C2-type 2
TgeneNTRK1chr12:58008800chr1:156841415ENST00000368196516510_781239791.0DomainProtein kinase
TgeneNTRK1chr12:58008800chr1:156841415ENST00000392302617299_365209761.0DomainIg-like C2-type 2
TgeneNTRK1chr12:58008800chr1:156841415ENST00000392302617510_781209761.0DomainProtein kinase
TgeneNTRK1chr12:58008800chr1:156841415ENST00000524377517299_365239797.0DomainIg-like C2-type 2
TgeneNTRK1chr12:58008800chr1:156841415ENST00000524377517510_781239797.0DomainProtein kinase
TgeneNTRK1chr12:58008800chr1:156841415ENST00000368196516537_541239791.0MotifDXXLL
TgeneNTRK1chr12:58008800chr1:156841415ENST00000368196516607_611239791.0MotifDXXLL
TgeneNTRK1chr12:58008800chr1:156841415ENST00000392302617537_541209761.0MotifDXXLL
TgeneNTRK1chr12:58008800chr1:156841415ENST00000392302617607_611209761.0MotifDXXLL
TgeneNTRK1chr12:58008800chr1:156841415ENST00000524377517537_541239797.0MotifDXXLL
TgeneNTRK1chr12:58008800chr1:156841415ENST00000524377517607_611239797.0MotifDXXLL
TgeneNTRK1chr12:58008800chr1:156841415ENST00000368196516516_524239791.0Nucleotide bindingATP
TgeneNTRK1chr12:58008800chr1:156841415ENST00000392302617516_524209761.0Nucleotide bindingATP
TgeneNTRK1chr12:58008800chr1:156841415ENST00000524377517516_524239797.0Nucleotide bindingATP
TgeneNTRK1chr12:58008800chr1:156841415ENST00000368196516440_796239791.0Topological domainCytoplasmic
TgeneNTRK1chr12:58008800chr1:156841415ENST00000392302617440_796209761.0Topological domainCytoplasmic
TgeneNTRK1chr12:58008800chr1:156841415ENST00000524377517440_796239797.0Topological domainCytoplasmic
TgeneNTRK1chr12:58008800chr1:156841415ENST00000368196516424_439239791.0TransmembraneHelical
TgeneNTRK1chr12:58008800chr1:156841415ENST00000392302617424_439209761.0TransmembraneHelical
TgeneNTRK1chr12:58008800chr1:156841415ENST00000524377517424_439239797.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF25chr12:58008800chr1:156841415ENST00000286494+1015160_336320581.0DomainDH
HgeneARHGEF25chr12:58008800chr1:156841415ENST00000286494+1015348_466320581.0DomainPH
HgeneARHGEF25chr12:58008800chr1:156841415ENST00000333972+1116348_466359620.0DomainPH
HgeneARHGEF25chr12:58008800chr1:156841415ENST00000286494+1015467_493320581.0RegionNote=Sufficient to bind activated GNAQ
HgeneARHGEF25chr12:58008800chr1:156841415ENST00000333972+1116467_493359620.0RegionNote=Sufficient to bind activated GNAQ
TgeneNTRK1chr12:58008800chr1:156841415ENST00000368196516148_193239791.0DomainNote=LRRCT
TgeneNTRK1chr12:58008800chr1:156841415ENST00000368196516194_283239791.0DomainIg-like C2-type 1
TgeneNTRK1chr12:58008800chr1:156841415ENST00000392302617148_193209761.0DomainNote=LRRCT
TgeneNTRK1chr12:58008800chr1:156841415ENST00000392302617194_283209761.0DomainIg-like C2-type 1
TgeneNTRK1chr12:58008800chr1:156841415ENST00000524377517148_193239797.0DomainNote=LRRCT
TgeneNTRK1chr12:58008800chr1:156841415ENST00000524377517194_283239797.0DomainIg-like C2-type 1
TgeneNTRK1chr12:58008800chr1:156841415ENST00000368196516116_137239791.0RepeatNote=LRR 2
TgeneNTRK1chr12:58008800chr1:156841415ENST0000036819651690_113239791.0RepeatNote=LRR 1
TgeneNTRK1chr12:58008800chr1:156841415ENST00000392302617116_137209761.0RepeatNote=LRR 2
TgeneNTRK1chr12:58008800chr1:156841415ENST0000039230261790_113209761.0RepeatNote=LRR 1
TgeneNTRK1chr12:58008800chr1:156841415ENST00000524377517116_137239797.0RepeatNote=LRR 2
TgeneNTRK1chr12:58008800chr1:156841415ENST0000052437751790_113239797.0RepeatNote=LRR 1
TgeneNTRK1chr12:58008800chr1:156841415ENST0000036819651633_423239791.0Topological domainExtracellular
TgeneNTRK1chr12:58008800chr1:156841415ENST0000039230261733_423209761.0Topological domainExtracellular
TgeneNTRK1chr12:58008800chr1:156841415ENST0000052437751733_423239797.0Topological domainExtracellular


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Fusion Gene Sequence for ARHGEF25-NTRK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6265_6265_1_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000286494_NTRK1_chr1_156841415_ENST00000358660_length(transcript)=3154nt_BP=1420nt
ATTCAGCTCTCCGCTCCGCTGGGACCCGCACAGCGCCAGTGGCTCGGGGGTCGGCCCTCGCCTCCTCCCCGGCCCGGGCCTAGAGCCACC
CCTAACCAGAGGCCGGAGACAGCTGGAGCGGCTGCCGCATCCCGGCCCAGCCTCCCCTACCATCCCTCCCCCTTCCACTGGACATCTGGA
CCCTAGGCCCCCGCACCGACAGGGTTCCGGAAACCCTCCCCGCCCAGCCCGGCGGCCGGGCCCCGCGCCTCTCTCTCTCTAGAGCCCCCA
GCCCTCCTCAAGACTAGACTTCCGCCTACCCCTGGACACCTCCTCCCGGTCCCCTCCCTCCCCCCCTCCCACAGCCTGGACCGGGGTAGG
AGGGAGGGGGGGTGTGCGCCCGGCGCCGTCCCCGCCCCGCCCCCCGTGATTCCCCCTGCATGGCCGGCCCGGGTGGGGGGCGCGGGGGGG
CCCGGGCGCCATGCGGGGGGGGCACAAAGGGGGTCGCTGTGCCTGTCCCCGTGTGATCCGAAAAGTGCTGGCAAAATGCGGCTGCTGCTT
CGCCCGGGGGGGACGTGAATCCTATTCCATTGCGGGCAGTGAGGGGAGTATATCGGCTTCTGCTGCCTCCGGTCTGGCTGCCCCCTCTGG
CCCCAGCTCTGGCCTCAGCTCTGGCCCCTGTTCCCCAGGCCCCCCAGGGCCCGTCAGTGGCCTGAGGAGATGGTTGGATCATTCCAAACA
TTGTCTCAGTGTGGAAACTGAGGCAGACAGTGGTCAGGCAGGACCATATGAGAACTGGATGTTGGAGCCAGCTCTAGCCACAGGAGAGGA
GCTGCCGGAACTGACCTTGCTGACCACACTGTTGGAGGGCCCTGGAGATAAGACGCAGCCACCTGAAGAGGAGACTTTGTCCCAAGCCCC
TGAGAGTGAGGAGGAACAGAAGAAGAAGGCTCTGGAAAGGAGTATGTATGTCCTGAGTGAACTGGTAGAAACAGAGAAAATGTACGTGGA
CGACTTGGGGCAGATTGTGGAGGGTTATATGGCCACCATGGCTGCTCAGGGGGTCCCCGAGAGTCTTCGAGGCCGTGACAGGATTGTGTT
TGGGAATATCCAGCAAATCTATGAGTGGCACCGAGACTATTTCTTGCAAGAGCTACAACGGTGTCTGAAAGATCCTGATTGGCTGGCTCA
GCTATTCATCAAACACGAGCGCCGGCTGCATATGTATGTGGTGTACTGTCAGAATAAGCCCAAGTCAGAGCATGTGGTGTCAGAGTTTGG
GGACAGCTACTTTGAGGAGCTCCGGCAGCAGCTGGGGCACCGCCTGCAGCTGAACGACCTCCTCATCAAACCTGTGCAGCGGATCATGAA
ATACCAGCTGCTGCTCAAGGATTTTCTCAAGTATTACAATAGAGCTGGGATGGATACTGCAGACCTAGAGAAATCTGGGGGTCTGCCATC
CCTGGGGCTGACCCTGGCCAATGTCACCAGTGACCTCAACAGGAAGAACGTGACGTGCTGGGCAGAGAACGATGTGGGCCGGGCAGAGGT
CTCTGTTCAGGTCAACGTCTCCTTCCCGGCCAGTGTGCAGCTGCACACGGCGGTGGAGATGCACCACTGGTGCATCCCCTTCTCTGTGGA
TGGGCAGCCGGCACCGTCTCTGCGCTGGCTCTTCAATGGCTCCGTGCTCAATGAGACCAGCTTCATCTTCACTGAGTTCCTGGAGCCGGC
AGCCAATGAGACCGTGCGGCACGGGTGTCTGCGCCTCAACCAGCCCACCCACGTCAACAACGGCAACTACACGCTGCTGGCTGCCAACCC
CTTCGGCCAGGCCTCCGCCTCCATCATGGCTGCCTTCATGGACAACCCTTTCGAGTTCAACCCCGAGGACCCCATCCCTGACACTAACAG
CACATCTGGAGACCCGGTGGAGAAGAAGGACGAAACACCTTTTGGGGTCTCGGTGGCTGTGGGCCTGGCCGTCTTTGCCTGCCTCTTCCT
TTCTACGCTGCTCCTTGTGCTCAACAAATGTGGACGGAGAAACAAGTTTGGGATCAACCGCCCGGCTGTGCTGGCTCCAGAGGATGGGCT
GGCCATGTCCCTGCATTTCATGACATTGGGTGGCAGCTCCCTGTCCCCCACCGAGGGCAAAGGCTCTGGGCTCCAAGGCCACATCATCGA
GAACCCACAATACTTCAGTGATGCCTCCCCCTCAGGTGTTCACCACATCAAGCGCCGGGACATCGTGCTCAAGTGGGAGCTGGGGGAGGG
CGCCTTTGGGAAGGTCTTCCTTGCTGAGTGCCACAACCTCCTGCCTGAGCAGGACAAGATGCTGGTGGCTGTCAAGGCACTGAAGGAGGC
GTCCGAGAGTGCTCGGCAGGACTTCCAGCGTGAGGCTGAGCTGCTCACCATGCTGCAGCACCAGCACATCGTGCGCTTCTTCGGCGTCTG
CACCGAGGGCCGCCCCCTGCTCATGGTCTTTGAGTATATGCGGCACGGGGACCTCAACCGCTTCCTCCGATCCCATGGACCTGATGCCAA
GCTGCTGGCTGGTGGGGAGGATGTGGCTCCAGGCCCCCTGGGTCTGGGGCAGCTGCTGGCCGTGGCTAGCCAGGTCGCTGCGGGGATGGT
GTACCTGGCGGGTCTGCATTTTGTGCACCGGGACCTGGCCACACGCAACTGTCTAGTGGGCCAGGGACTGGTGGTCAAGATTGGTGATTT
TGGCATGAGCAGGGATATCTACAGCACCGACTATTACCGTGTGGGAGGCCGCACCATGCTGCCCATTCGCTGGATGCCGCCCGAGAGCAT
CCTGTACCGTAAGTTCACCACCGAGAGCGACGTGTGGAGCTTCGGCGTGGTGCTCTGGGAGATCTTCACCTACGGCAAGCAGCCCTGGTA
CCAGCTCTCCAACACGGAGGCAATCGACTGCATCACGCAGGGACGTGAGTTGGAGCGGCCACGTGCCTGCCCACCAGAGGTCTACGCCAT
CATGCGGGGCTGCTGGCAGCGGGAGCCCCAGCAACGCCACAGCATCAAGGATGTGCACGCCCGGCTGCAAGCCCTGGCCCAGGCACCTCC
TGTCTACCTGGATGTCCTGGGCTAGGGGGCCGGCCCAGGGGCTGGGAGTGGTTAGCCGGAATACTGGGGCCTGCCCTCAGCATCCCCCAT

>6265_6265_1_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000286494_NTRK1_chr1_156841415_ENST00000358660_length(amino acids)=889AA_BP=335
MHGRPGWGARGGPGAMRGGHKGGRCACPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPV
SGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVL
SELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQN
KPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEKSGGLPSLGLTLANVTSDLNRKNVT
CWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHV
NNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGI
NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQD
KMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQL
LAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVL

--------------------------------------------------------------
>6265_6265_2_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000286494_NTRK1_chr1_156841415_ENST00000368196_length(transcript)=3284nt_BP=1420nt
ATTCAGCTCTCCGCTCCGCTGGGACCCGCACAGCGCCAGTGGCTCGGGGGTCGGCCCTCGCCTCCTCCCCGGCCCGGGCCTAGAGCCACC
CCTAACCAGAGGCCGGAGACAGCTGGAGCGGCTGCCGCATCCCGGCCCAGCCTCCCCTACCATCCCTCCCCCTTCCACTGGACATCTGGA
CCCTAGGCCCCCGCACCGACAGGGTTCCGGAAACCCTCCCCGCCCAGCCCGGCGGCCGGGCCCCGCGCCTCTCTCTCTCTAGAGCCCCCA
GCCCTCCTCAAGACTAGACTTCCGCCTACCCCTGGACACCTCCTCCCGGTCCCCTCCCTCCCCCCCTCCCACAGCCTGGACCGGGGTAGG
AGGGAGGGGGGGTGTGCGCCCGGCGCCGTCCCCGCCCCGCCCCCCGTGATTCCCCCTGCATGGCCGGCCCGGGTGGGGGGCGCGGGGGGG
CCCGGGCGCCATGCGGGGGGGGCACAAAGGGGGTCGCTGTGCCTGTCCCCGTGTGATCCGAAAAGTGCTGGCAAAATGCGGCTGCTGCTT
CGCCCGGGGGGGACGTGAATCCTATTCCATTGCGGGCAGTGAGGGGAGTATATCGGCTTCTGCTGCCTCCGGTCTGGCTGCCCCCTCTGG
CCCCAGCTCTGGCCTCAGCTCTGGCCCCTGTTCCCCAGGCCCCCCAGGGCCCGTCAGTGGCCTGAGGAGATGGTTGGATCATTCCAAACA
TTGTCTCAGTGTGGAAACTGAGGCAGACAGTGGTCAGGCAGGACCATATGAGAACTGGATGTTGGAGCCAGCTCTAGCCACAGGAGAGGA
GCTGCCGGAACTGACCTTGCTGACCACACTGTTGGAGGGCCCTGGAGATAAGACGCAGCCACCTGAAGAGGAGACTTTGTCCCAAGCCCC
TGAGAGTGAGGAGGAACAGAAGAAGAAGGCTCTGGAAAGGAGTATGTATGTCCTGAGTGAACTGGTAGAAACAGAGAAAATGTACGTGGA
CGACTTGGGGCAGATTGTGGAGGGTTATATGGCCACCATGGCTGCTCAGGGGGTCCCCGAGAGTCTTCGAGGCCGTGACAGGATTGTGTT
TGGGAATATCCAGCAAATCTATGAGTGGCACCGAGACTATTTCTTGCAAGAGCTACAACGGTGTCTGAAAGATCCTGATTGGCTGGCTCA
GCTATTCATCAAACACGAGCGCCGGCTGCATATGTATGTGGTGTACTGTCAGAATAAGCCCAAGTCAGAGCATGTGGTGTCAGAGTTTGG
GGACAGCTACTTTGAGGAGCTCCGGCAGCAGCTGGGGCACCGCCTGCAGCTGAACGACCTCCTCATCAAACCTGTGCAGCGGATCATGAA
ATACCAGCTGCTGCTCAAGGATTTTCTCAAGTATTACAATAGAGCTGGGATGGATACTGCAGACCTAGAGAAATCTGGGGGTCTGCCATC
CCTGGGGCTGACCCTGGCCAATGTCACCAGTGACCTCAACAGGAAGAACGTGACGTGCTGGGCAGAGAACGATGTGGGCCGGGCAGAGGT
CTCTGTTCAGGTCAACGTCTCCTTCCCGGCCAGTGTGCAGCTGCACACGGCGGTGGAGATGCACCACTGGTGCATCCCCTTCTCTGTGGA
TGGGCAGCCGGCACCGTCTCTGCGCTGGCTCTTCAATGGCTCCGTGCTCAATGAGACCAGCTTCATCTTCACTGAGTTCCTGGAGCCGGC
AGCCAATGAGACCGTGCGGCACGGGTGTCTGCGCCTCAACCAGCCCACCCACGTCAACAACGGCAACTACACGCTGCTGGCTGCCAACCC
CTTCGGCCAGGCCTCCGCCTCCATCATGGCTGCCTTCATGGACAACCCTTTCGAGTTCAACCCCGAGGACCCCATCCCTGACACTAACAG
CACATCTGGAGACCCGGTGGAGAAGAAGGACGAAACACCTTTTGGGGTCTCGGTGGCTGTGGGCCTGGCCGTCTTTGCCTGCCTCTTCCT
TTCTACGCTGCTCCTTGTGCTCAACAAATGTGGACGGAGAAACAAGTTTGGGATCAACCGCCCGGCTGTGCTGGCTCCAGAGGATGGGCT
GGCCATGTCCCTGCATTTCATGACATTGGGTGGCAGCTCCCTGTCCCCCACCGAGGGCAAAGGCTCTGGGCTCCAAGGCCACATCATCGA
GAACCCACAATACTTCAGTGATGCCTGTGTTCACCACATCAAGCGCCGGGACATCGTGCTCAAGTGGGAGCTGGGGGAGGGCGCCTTTGG
GAAGGTCTTCCTTGCTGAGTGCCACAACCTCCTGCCTGAGCAGGACAAGATGCTGGTGGCTGTCAAGGCACTGAAGGAGGCGTCCGAGAG
TGCTCGGCAGGACTTCCAGCGTGAGGCTGAGCTGCTCACCATGCTGCAGCACCAGCACATCGTGCGCTTCTTCGGCGTCTGCACCGAGGG
CCGCCCCCTGCTCATGGTCTTTGAGTATATGCGGCACGGGGACCTCAACCGCTTCCTCCGATCCCATGGACCTGATGCCAAGCTGCTGGC
TGGTGGGGAGGATGTGGCTCCAGGCCCCCTGGGTCTGGGGCAGCTGCTGGCCGTGGCTAGCCAGGTCGCTGCGGGGATGGTGTACCTGGC
GGGTCTGCATTTTGTGCACCGGGACCTGGCCACACGCAACTGTCTAGTGGGCCAGGGACTGGTGGTCAAGATTGGTGATTTTGGCATGAG
CAGGGATATCTACAGCACCGACTATTACCGTGTGGGAGGCCGCACCATGCTGCCCATTCGCTGGATGCCGCCCGAGAGCATCCTGTACCG
TAAGTTCACCACCGAGAGCGACGTGTGGAGCTTCGGCGTGGTGCTCTGGGAGATCTTCACCTACGGCAAGCAGCCCTGGTACCAGCTCTC
CAACACGGAGGCAATCGACTGCATCACGCAGGGACGTGAGTTGGAGCGGCCACGTGCCTGCCCACCAGAGGTCTACGCCATCATGCGGGG
CTGCTGGCAGCGGGAGCCCCAGCAACGCCACAGCATCAAGGATGTGCACGCCCGGCTGCAAGCCCTGGCCCAGGCACCTCCTGTCTACCT
GGATGTCCTGGGCTAGGGGGCCGGCCCAGGGGCTGGGAGTGGTTAGCCGGAATACTGGGGCCTGCCCTCAGCATCCCCCATAGCTCCCAG
CAGCCCCAGGGTGATCTCAAAGTATCTAATTCACCCTCAGCATGTGGGAAGGGACAGGTGGGGGCTGGGAGTAGAGGATGTTCCTGCTTC

>6265_6265_2_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000286494_NTRK1_chr1_156841415_ENST00000368196_length(amino acids)=886AA_BP=335
MHGRPGWGARGGPGAMRGGHKGGRCACPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPV
SGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVL
SELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQN
KPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEKSGGLPSLGLTLANVTSDLNRKNVT
CWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHV
NNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGI
NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAV
ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI

--------------------------------------------------------------
>6265_6265_3_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000286494_NTRK1_chr1_156841415_ENST00000392302_length(transcript)=3228nt_BP=1420nt
ATTCAGCTCTCCGCTCCGCTGGGACCCGCACAGCGCCAGTGGCTCGGGGGTCGGCCCTCGCCTCCTCCCCGGCCCGGGCCTAGAGCCACC
CCTAACCAGAGGCCGGAGACAGCTGGAGCGGCTGCCGCATCCCGGCCCAGCCTCCCCTACCATCCCTCCCCCTTCCACTGGACATCTGGA
CCCTAGGCCCCCGCACCGACAGGGTTCCGGAAACCCTCCCCGCCCAGCCCGGCGGCCGGGCCCCGCGCCTCTCTCTCTCTAGAGCCCCCA
GCCCTCCTCAAGACTAGACTTCCGCCTACCCCTGGACACCTCCTCCCGGTCCCCTCCCTCCCCCCCTCCCACAGCCTGGACCGGGGTAGG
AGGGAGGGGGGGTGTGCGCCCGGCGCCGTCCCCGCCCCGCCCCCCGTGATTCCCCCTGCATGGCCGGCCCGGGTGGGGGGCGCGGGGGGG
CCCGGGCGCCATGCGGGGGGGGCACAAAGGGGGTCGCTGTGCCTGTCCCCGTGTGATCCGAAAAGTGCTGGCAAAATGCGGCTGCTGCTT
CGCCCGGGGGGGACGTGAATCCTATTCCATTGCGGGCAGTGAGGGGAGTATATCGGCTTCTGCTGCCTCCGGTCTGGCTGCCCCCTCTGG
CCCCAGCTCTGGCCTCAGCTCTGGCCCCTGTTCCCCAGGCCCCCCAGGGCCCGTCAGTGGCCTGAGGAGATGGTTGGATCATTCCAAACA
TTGTCTCAGTGTGGAAACTGAGGCAGACAGTGGTCAGGCAGGACCATATGAGAACTGGATGTTGGAGCCAGCTCTAGCCACAGGAGAGGA
GCTGCCGGAACTGACCTTGCTGACCACACTGTTGGAGGGCCCTGGAGATAAGACGCAGCCACCTGAAGAGGAGACTTTGTCCCAAGCCCC
TGAGAGTGAGGAGGAACAGAAGAAGAAGGCTCTGGAAAGGAGTATGTATGTCCTGAGTGAACTGGTAGAAACAGAGAAAATGTACGTGGA
CGACTTGGGGCAGATTGTGGAGGGTTATATGGCCACCATGGCTGCTCAGGGGGTCCCCGAGAGTCTTCGAGGCCGTGACAGGATTGTGTT
TGGGAATATCCAGCAAATCTATGAGTGGCACCGAGACTATTTCTTGCAAGAGCTACAACGGTGTCTGAAAGATCCTGATTGGCTGGCTCA
GCTATTCATCAAACACGAGCGCCGGCTGCATATGTATGTGGTGTACTGTCAGAATAAGCCCAAGTCAGAGCATGTGGTGTCAGAGTTTGG
GGACAGCTACTTTGAGGAGCTCCGGCAGCAGCTGGGGCACCGCCTGCAGCTGAACGACCTCCTCATCAAACCTGTGCAGCGGATCATGAA
ATACCAGCTGCTGCTCAAGGATTTTCTCAAGTATTACAATAGAGCTGGGATGGATACTGCAGACCTAGAGAAATCTGGGGGTCTGCCATC
CCTGGGGCTGACCCTGGCCAATGTCACCAGTGACCTCAACAGGAAGAACGTGACGTGCTGGGCAGAGAACGATGTGGGCCGGGCAGAGGT
CTCTGTTCAGGTCAACGTCTCCTTCCCGGCCAGTGTGCAGCTGCACACGGCGGTGGAGATGCACCACTGGTGCATCCCCTTCTCTGTGGA
TGGGCAGCCGGCACCGTCTCTGCGCTGGCTCTTCAATGGCTCCGTGCTCAATGAGACCAGCTTCATCTTCACTGAGTTCCTGGAGCCGGC
AGCCAATGAGACCGTGCGGCACGGGTGTCTGCGCCTCAACCAGCCCACCCACGTCAACAACGGCAACTACACGCTGCTGGCTGCCAACCC
CTTCGGCCAGGCCTCCGCCTCCATCATGGCTGCCTTCATGGACAACCCTTTCGAGTTCAACCCCGAGGACCCCATCCCTGACACTAACAG
CACATCTGGAGACCCGGTGGAGAAGAAGGACGAAACACCTTTTGGGGTCTCGGTGGCTGTGGGCCTGGCCGTCTTTGCCTGCCTCTTCCT
TTCTACGCTGCTCCTTGTGCTCAACAAATGTGGACGGAGAAACAAGTTTGGGATCAACCGCCCGGCTGTGCTGGCTCCAGAGGATGGGCT
GGCCATGTCCCTGCATTTCATGACATTGGGTGGCAGCTCCCTGTCCCCCACCGAGGGCAAAGGCTCTGGGCTCCAAGGCCACATCATCGA
GAACCCACAATACTTCAGTGATGCCTGTGTTCACCACATCAAGCGCCGGGACATCGTGCTCAAGTGGGAGCTGGGGGAGGGCGCCTTTGG
GAAGGTCTTCCTTGCTGAGTGCCACAACCTCCTGCCTGAGCAGGACAAGATGCTGGTGGCTGTCAAGGCACTGAAGGAGGCGTCCGAGAG
TGCTCGGCAGGACTTCCAGCGTGAGGCTGAGCTGCTCACCATGCTGCAGCACCAGCACATCGTGCGCTTCTTCGGCGTCTGCACCGAGGG
CCGCCCCCTGCTCATGGTCTTTGAGTATATGCGGCACGGGGACCTCAACCGCTTCCTCCGATCCCATGGACCTGATGCCAAGCTGCTGGC
TGGTGGGGAGGATGTGGCTCCAGGCCCCCTGGGTCTGGGGCAGCTGCTGGCCGTGGCTAGCCAGGTCGCTGCGGGGATGGTGTACCTGGC
GGGTCTGCATTTTGTGCACCGGGACCTGGCCACACGCAACTGTCTAGTGGGCCAGGGACTGGTGGTCAAGATTGGTGATTTTGGCATGAG
CAGGGATATCTACAGCACCGACTATTACCGTGTGGGAGGCCGCACCATGCTGCCCATTCGCTGGATGCCGCCCGAGAGCATCCTGTACCG
TAAGTTCACCACCGAGAGCGACGTGTGGAGCTTCGGCGTGGTGCTCTGGGAGATCTTCACCTACGGCAAGCAGCCCTGGTACCAGCTCTC
CAACACGGAGGCAATCGACTGCATCACGCAGGGACGTGAGTTGGAGCGGCCACGTGCCTGCCCACCAGAGGTCTACGCCATCATGCGGGG
CTGCTGGCAGCGGGAGCCCCAGCAACGCCACAGCATCAAGGATGTGCACGCCCGGCTGCAAGCCCTGGCCCAGGCACCTCCTGTCTACCT
GGATGTCCTGGGCTAGGGGGCCGGCCCAGGGGCTGGGAGTGGTTAGCCGGAATACTGGGGCCTGCCCTCAGCATCCCCCATAGCTCCCAG

>6265_6265_3_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000286494_NTRK1_chr1_156841415_ENST00000392302_length(amino acids)=886AA_BP=335
MHGRPGWGARGGPGAMRGGHKGGRCACPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPV
SGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVL
SELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQN
KPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEKSGGLPSLGLTLANVTSDLNRKNVT
CWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHV
NNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGI
NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAV
ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI

--------------------------------------------------------------
>6265_6265_4_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000286494_NTRK1_chr1_156841415_ENST00000524377_length(transcript)=3094nt_BP=1420nt
ATTCAGCTCTCCGCTCCGCTGGGACCCGCACAGCGCCAGTGGCTCGGGGGTCGGCCCTCGCCTCCTCCCCGGCCCGGGCCTAGAGCCACC
CCTAACCAGAGGCCGGAGACAGCTGGAGCGGCTGCCGCATCCCGGCCCAGCCTCCCCTACCATCCCTCCCCCTTCCACTGGACATCTGGA
CCCTAGGCCCCCGCACCGACAGGGTTCCGGAAACCCTCCCCGCCCAGCCCGGCGGCCGGGCCCCGCGCCTCTCTCTCTCTAGAGCCCCCA
GCCCTCCTCAAGACTAGACTTCCGCCTACCCCTGGACACCTCCTCCCGGTCCCCTCCCTCCCCCCCTCCCACAGCCTGGACCGGGGTAGG
AGGGAGGGGGGGTGTGCGCCCGGCGCCGTCCCCGCCCCGCCCCCCGTGATTCCCCCTGCATGGCCGGCCCGGGTGGGGGGCGCGGGGGGG
CCCGGGCGCCATGCGGGGGGGGCACAAAGGGGGTCGCTGTGCCTGTCCCCGTGTGATCCGAAAAGTGCTGGCAAAATGCGGCTGCTGCTT
CGCCCGGGGGGGACGTGAATCCTATTCCATTGCGGGCAGTGAGGGGAGTATATCGGCTTCTGCTGCCTCCGGTCTGGCTGCCCCCTCTGG
CCCCAGCTCTGGCCTCAGCTCTGGCCCCTGTTCCCCAGGCCCCCCAGGGCCCGTCAGTGGCCTGAGGAGATGGTTGGATCATTCCAAACA
TTGTCTCAGTGTGGAAACTGAGGCAGACAGTGGTCAGGCAGGACCATATGAGAACTGGATGTTGGAGCCAGCTCTAGCCACAGGAGAGGA
GCTGCCGGAACTGACCTTGCTGACCACACTGTTGGAGGGCCCTGGAGATAAGACGCAGCCACCTGAAGAGGAGACTTTGTCCCAAGCCCC
TGAGAGTGAGGAGGAACAGAAGAAGAAGGCTCTGGAAAGGAGTATGTATGTCCTGAGTGAACTGGTAGAAACAGAGAAAATGTACGTGGA
CGACTTGGGGCAGATTGTGGAGGGTTATATGGCCACCATGGCTGCTCAGGGGGTCCCCGAGAGTCTTCGAGGCCGTGACAGGATTGTGTT
TGGGAATATCCAGCAAATCTATGAGTGGCACCGAGACTATTTCTTGCAAGAGCTACAACGGTGTCTGAAAGATCCTGATTGGCTGGCTCA
GCTATTCATCAAACACGAGCGCCGGCTGCATATGTATGTGGTGTACTGTCAGAATAAGCCCAAGTCAGAGCATGTGGTGTCAGAGTTTGG
GGACAGCTACTTTGAGGAGCTCCGGCAGCAGCTGGGGCACCGCCTGCAGCTGAACGACCTCCTCATCAAACCTGTGCAGCGGATCATGAA
ATACCAGCTGCTGCTCAAGGATTTTCTCAAGTATTACAATAGAGCTGGGATGGATACTGCAGACCTAGAGAAATCTGGGGGTCTGCCATC
CCTGGGGCTGACCCTGGCCAATGTCACCAGTGACCTCAACAGGAAGAACGTGACGTGCTGGGCAGAGAACGATGTGGGCCGGGCAGAGGT
CTCTGTTCAGGTCAACGTCTCCTTCCCGGCCAGTGTGCAGCTGCACACGGCGGTGGAGATGCACCACTGGTGCATCCCCTTCTCTGTGGA
TGGGCAGCCGGCACCGTCTCTGCGCTGGCTCTTCAATGGCTCCGTGCTCAATGAGACCAGCTTCATCTTCACTGAGTTCCTGGAGCCGGC
AGCCAATGAGACCGTGCGGCACGGGTGTCTGCGCCTCAACCAGCCCACCCACGTCAACAACGGCAACTACACGCTGCTGGCTGCCAACCC
CTTCGGCCAGGCCTCCGCCTCCATCATGGCTGCCTTCATGGACAACCCTTTCGAGTTCAACCCCGAGGACCCCATCCCTGTCTCCTTCTC
GCCGGTGGACACTAACAGCACATCTGGAGACCCGGTGGAGAAGAAGGACGAAACACCTTTTGGGGTCTCGGTGGCTGTGGGCCTGGCCGT
CTTTGCCTGCCTCTTCCTTTCTACGCTGCTCCTTGTGCTCAACAAATGTGGACGGAGAAACAAGTTTGGGATCAACCGCCCGGCTGTGCT
GGCTCCAGAGGATGGGCTGGCCATGTCCCTGCATTTCATGACATTGGGTGGCAGCTCCCTGTCCCCCACCGAGGGCAAAGGCTCTGGGCT
CCAAGGCCACATCATCGAGAACCCACAATACTTCAGTGATGCCTGTGTTCACCACATCAAGCGCCGGGACATCGTGCTCAAGTGGGAGCT
GGGGGAGGGCGCCTTTGGGAAGGTCTTCCTTGCTGAGTGCCACAACCTCCTGCCTGAGCAGGACAAGATGCTGGTGGCTGTCAAGGCACT
GAAGGAGGCGTCCGAGAGTGCTCGGCAGGACTTCCAGCGTGAGGCTGAGCTGCTCACCATGCTGCAGCACCAGCACATCGTGCGCTTCTT
CGGCGTCTGCACCGAGGGCCGCCCCCTGCTCATGGTCTTTGAGTATATGCGGCACGGGGACCTCAACCGCTTCCTCCGATCCCATGGACC
TGATGCCAAGCTGCTGGCTGGTGGGGAGGATGTGGCTCCAGGCCCCCTGGGTCTGGGGCAGCTGCTGGCCGTGGCTAGCCAGGTCGCTGC
GGGGATGGTGTACCTGGCGGGTCTGCATTTTGTGCACCGGGACCTGGCCACACGCAACTGTCTAGTGGGCCAGGGACTGGTGGTCAAGAT
TGGTGATTTTGGCATGAGCAGGGATATCTACAGCACCGACTATTACCGTGTGGGAGGCCGCACCATGCTGCCCATTCGCTGGATGCCGCC
CGAGAGCATCCTGTACCGTAAGTTCACCACCGAGAGCGACGTGTGGAGCTTCGGCGTGGTGCTCTGGGAGATCTTCACCTACGGCAAGCA
GCCCTGGTACCAGCTCTCCAACACGGAGGCAATCGACTGCATCACGCAGGGACGTGAGTTGGAGCGGCCACGTGCCTGCCCACCAGAGGT
CTACGCCATCATGCGGGGCTGCTGGCAGCGGGAGCCCCAGCAACGCCACAGCATCAAGGATGTGCACGCCCGGCTGCAAGCCCTGGCCCA

>6265_6265_4_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000286494_NTRK1_chr1_156841415_ENST00000524377_length(amino acids)=893AA_BP=335
MHGRPGWGARGGPGAMRGGHKGGRCACPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPV
SGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVL
SELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQN
KPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEKSGGLPSLGLTLANVTSDLNRKNVT
CWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHV
NNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGR
RNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLP
EQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGL
GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFG

--------------------------------------------------------------
>6265_6265_5_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000333972_NTRK1_chr1_156841415_ENST00000358660_length(transcript)=2848nt_BP=1114nt
CTCGACCCTGAAACTTGGAGCAGGGTGGGGGTTCAGTATGAAGCCCCCGGACCGCCCCGCCCCTGGCCGCACTGACCGGATACTGGGGGT
CATGGGGGGCATGCTGCGCGCATGCGCCCTCCCTGGGCAGGAGGGGCCCCCAAGGAGAAGCCCTCTAGGGTTGGTGGGTACCGAGCCAGA
GTCTGAACGTACGGAGGGAGATCACAGAAGGGATCGCGAACATGAGGTCCTCGCCGGGGCTCTGCAGCCCGAATCCTATTCCATTGCGGG
CAGTGAGGGGAGTATATCGGCTTCTGCTGCCTCCGGTCTGGCTGCCCCCTCTGGCCCCAGCTCTGGCCTCAGCTCTGGCCCCTGTTCCCC
AGGCCCCCCAGGGCCCGTCAGTGGCCTGAGGAGATGGTTGGATCATTCCAAACATTGTCTCAGTGTGGAAACTGAGGCAGACAGTGGTCA
GGCAGGACCATATGAGAACTGGATGTTGGAGCCAGCTCTAGCCACAGGAGAGGAGCTGCCGGAACTGACCTTGCTGACCACACTGTTGGA
GGGCCCTGGAGATAAGACGCAGCCACCTGAAGAGGAGACTTTGTCCCAAGCCCCTGAGAGTGAGGAGGAACAGAAGAAGAAGGCTCTGGA
AAGGAGTATGTATGTCCTGAGTGAACTGGTAGAAACAGAGAAAATGTACGTGGACGACTTGGGGCAGATTGTGGAGGGTTATATGGCCAC
CATGGCTGCTCAGGGGGTCCCCGAGAGTCTTCGAGGCCGTGACAGGATTGTGTTTGGGAATATCCAGCAAATCTATGAGTGGCACCGAGA
CTATTTCTTGCAAGAGCTACAACGGTGTCTGAAAGATCCTGATTGGCTGGCTCAGCTATTCATCAAACACGAGCGCCGGCTGCATATGTA
TGTGGTGTACTGTCAGAATAAGCCCAAGTCAGAGCATGTGGTGTCAGAGTTTGGGGACAGCTACTTTGAGGAGCTCCGGCAGCAGCTGGG
GCACCGCCTGCAGCTGAACGACCTCCTCATCAAACCTGTGCAGCGGATCATGAAATACCAGCTGCTGCTCAAGGATTTTCTCAAGTATTA
CAATAGAGCTGGGATGGATACTGCAGACCTAGAGAAATCTGGGGGTCTGCCATCCCTGGGGCTGACCCTGGCCAATGTCACCAGTGACCT
CAACAGGAAGAACGTGACGTGCTGGGCAGAGAACGATGTGGGCCGGGCAGAGGTCTCTGTTCAGGTCAACGTCTCCTTCCCGGCCAGTGT
GCAGCTGCACACGGCGGTGGAGATGCACCACTGGTGCATCCCCTTCTCTGTGGATGGGCAGCCGGCACCGTCTCTGCGCTGGCTCTTCAA
TGGCTCCGTGCTCAATGAGACCAGCTTCATCTTCACTGAGTTCCTGGAGCCGGCAGCCAATGAGACCGTGCGGCACGGGTGTCTGCGCCT
CAACCAGCCCACCCACGTCAACAACGGCAACTACACGCTGCTGGCTGCCAACCCCTTCGGCCAGGCCTCCGCCTCCATCATGGCTGCCTT
CATGGACAACCCTTTCGAGTTCAACCCCGAGGACCCCATCCCTGACACTAACAGCACATCTGGAGACCCGGTGGAGAAGAAGGACGAAAC
ACCTTTTGGGGTCTCGGTGGCTGTGGGCCTGGCCGTCTTTGCCTGCCTCTTCCTTTCTACGCTGCTCCTTGTGCTCAACAAATGTGGACG
GAGAAACAAGTTTGGGATCAACCGCCCGGCTGTGCTGGCTCCAGAGGATGGGCTGGCCATGTCCCTGCATTTCATGACATTGGGTGGCAG
CTCCCTGTCCCCCACCGAGGGCAAAGGCTCTGGGCTCCAAGGCCACATCATCGAGAACCCACAATACTTCAGTGATGCCTCCCCCTCAGG
TGTTCACCACATCAAGCGCCGGGACATCGTGCTCAAGTGGGAGCTGGGGGAGGGCGCCTTTGGGAAGGTCTTCCTTGCTGAGTGCCACAA
CCTCCTGCCTGAGCAGGACAAGATGCTGGTGGCTGTCAAGGCACTGAAGGAGGCGTCCGAGAGTGCTCGGCAGGACTTCCAGCGTGAGGC
TGAGCTGCTCACCATGCTGCAGCACCAGCACATCGTGCGCTTCTTCGGCGTCTGCACCGAGGGCCGCCCCCTGCTCATGGTCTTTGAGTA
TATGCGGCACGGGGACCTCAACCGCTTCCTCCGATCCCATGGACCTGATGCCAAGCTGCTGGCTGGTGGGGAGGATGTGGCTCCAGGCCC
CCTGGGTCTGGGGCAGCTGCTGGCCGTGGCTAGCCAGGTCGCTGCGGGGATGGTGTACCTGGCGGGTCTGCATTTTGTGCACCGGGACCT
GGCCACACGCAACTGTCTAGTGGGCCAGGGACTGGTGGTCAAGATTGGTGATTTTGGCATGAGCAGGGATATCTACAGCACCGACTATTA
CCGTGTGGGAGGCCGCACCATGCTGCCCATTCGCTGGATGCCGCCCGAGAGCATCCTGTACCGTAAGTTCACCACCGAGAGCGACGTGTG
GAGCTTCGGCGTGGTGCTCTGGGAGATCTTCACCTACGGCAAGCAGCCCTGGTACCAGCTCTCCAACACGGAGGCAATCGACTGCATCAC
GCAGGGACGTGAGTTGGAGCGGCCACGTGCCTGCCCACCAGAGGTCTACGCCATCATGCGGGGCTGCTGGCAGCGGGAGCCCCAGCAACG
CCACAGCATCAAGGATGTGCACGCCCGGCTGCAAGCCCTGGCCCAGGCACCTCCTGTCTACCTGGATGTCCTGGGCTAGGGGGCCGGCCC

>6265_6265_5_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000333972_NTRK1_chr1_156841415_ENST00000358660_length(amino acids)=923AA_BP=369
MKLGAGWGFSMKPPDRPAPGRTDRILGVMGGMLRACALPGQEGPPRRSPLGLVGTEPESERTEGDHRRDREHEVLAGALQPESYSIAGSE
GSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGP
GDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYF
LQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR
AGMDTADLEKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGS
VLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPF
GVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVH
HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMR
HGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRV
GGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHS

--------------------------------------------------------------
>6265_6265_6_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000333972_NTRK1_chr1_156841415_ENST00000368196_length(transcript)=2978nt_BP=1114nt
CTCGACCCTGAAACTTGGAGCAGGGTGGGGGTTCAGTATGAAGCCCCCGGACCGCCCCGCCCCTGGCCGCACTGACCGGATACTGGGGGT
CATGGGGGGCATGCTGCGCGCATGCGCCCTCCCTGGGCAGGAGGGGCCCCCAAGGAGAAGCCCTCTAGGGTTGGTGGGTACCGAGCCAGA
GTCTGAACGTACGGAGGGAGATCACAGAAGGGATCGCGAACATGAGGTCCTCGCCGGGGCTCTGCAGCCCGAATCCTATTCCATTGCGGG
CAGTGAGGGGAGTATATCGGCTTCTGCTGCCTCCGGTCTGGCTGCCCCCTCTGGCCCCAGCTCTGGCCTCAGCTCTGGCCCCTGTTCCCC
AGGCCCCCCAGGGCCCGTCAGTGGCCTGAGGAGATGGTTGGATCATTCCAAACATTGTCTCAGTGTGGAAACTGAGGCAGACAGTGGTCA
GGCAGGACCATATGAGAACTGGATGTTGGAGCCAGCTCTAGCCACAGGAGAGGAGCTGCCGGAACTGACCTTGCTGACCACACTGTTGGA
GGGCCCTGGAGATAAGACGCAGCCACCTGAAGAGGAGACTTTGTCCCAAGCCCCTGAGAGTGAGGAGGAACAGAAGAAGAAGGCTCTGGA
AAGGAGTATGTATGTCCTGAGTGAACTGGTAGAAACAGAGAAAATGTACGTGGACGACTTGGGGCAGATTGTGGAGGGTTATATGGCCAC
CATGGCTGCTCAGGGGGTCCCCGAGAGTCTTCGAGGCCGTGACAGGATTGTGTTTGGGAATATCCAGCAAATCTATGAGTGGCACCGAGA
CTATTTCTTGCAAGAGCTACAACGGTGTCTGAAAGATCCTGATTGGCTGGCTCAGCTATTCATCAAACACGAGCGCCGGCTGCATATGTA
TGTGGTGTACTGTCAGAATAAGCCCAAGTCAGAGCATGTGGTGTCAGAGTTTGGGGACAGCTACTTTGAGGAGCTCCGGCAGCAGCTGGG
GCACCGCCTGCAGCTGAACGACCTCCTCATCAAACCTGTGCAGCGGATCATGAAATACCAGCTGCTGCTCAAGGATTTTCTCAAGTATTA
CAATAGAGCTGGGATGGATACTGCAGACCTAGAGAAATCTGGGGGTCTGCCATCCCTGGGGCTGACCCTGGCCAATGTCACCAGTGACCT
CAACAGGAAGAACGTGACGTGCTGGGCAGAGAACGATGTGGGCCGGGCAGAGGTCTCTGTTCAGGTCAACGTCTCCTTCCCGGCCAGTGT
GCAGCTGCACACGGCGGTGGAGATGCACCACTGGTGCATCCCCTTCTCTGTGGATGGGCAGCCGGCACCGTCTCTGCGCTGGCTCTTCAA
TGGCTCCGTGCTCAATGAGACCAGCTTCATCTTCACTGAGTTCCTGGAGCCGGCAGCCAATGAGACCGTGCGGCACGGGTGTCTGCGCCT
CAACCAGCCCACCCACGTCAACAACGGCAACTACACGCTGCTGGCTGCCAACCCCTTCGGCCAGGCCTCCGCCTCCATCATGGCTGCCTT
CATGGACAACCCTTTCGAGTTCAACCCCGAGGACCCCATCCCTGACACTAACAGCACATCTGGAGACCCGGTGGAGAAGAAGGACGAAAC
ACCTTTTGGGGTCTCGGTGGCTGTGGGCCTGGCCGTCTTTGCCTGCCTCTTCCTTTCTACGCTGCTCCTTGTGCTCAACAAATGTGGACG
GAGAAACAAGTTTGGGATCAACCGCCCGGCTGTGCTGGCTCCAGAGGATGGGCTGGCCATGTCCCTGCATTTCATGACATTGGGTGGCAG
CTCCCTGTCCCCCACCGAGGGCAAAGGCTCTGGGCTCCAAGGCCACATCATCGAGAACCCACAATACTTCAGTGATGCCTGTGTTCACCA
CATCAAGCGCCGGGACATCGTGCTCAAGTGGGAGCTGGGGGAGGGCGCCTTTGGGAAGGTCTTCCTTGCTGAGTGCCACAACCTCCTGCC
TGAGCAGGACAAGATGCTGGTGGCTGTCAAGGCACTGAAGGAGGCGTCCGAGAGTGCTCGGCAGGACTTCCAGCGTGAGGCTGAGCTGCT
CACCATGCTGCAGCACCAGCACATCGTGCGCTTCTTCGGCGTCTGCACCGAGGGCCGCCCCCTGCTCATGGTCTTTGAGTATATGCGGCA
CGGGGACCTCAACCGCTTCCTCCGATCCCATGGACCTGATGCCAAGCTGCTGGCTGGTGGGGAGGATGTGGCTCCAGGCCCCCTGGGTCT
GGGGCAGCTGCTGGCCGTGGCTAGCCAGGTCGCTGCGGGGATGGTGTACCTGGCGGGTCTGCATTTTGTGCACCGGGACCTGGCCACACG
CAACTGTCTAGTGGGCCAGGGACTGGTGGTCAAGATTGGTGATTTTGGCATGAGCAGGGATATCTACAGCACCGACTATTACCGTGTGGG
AGGCCGCACCATGCTGCCCATTCGCTGGATGCCGCCCGAGAGCATCCTGTACCGTAAGTTCACCACCGAGAGCGACGTGTGGAGCTTCGG
CGTGGTGCTCTGGGAGATCTTCACCTACGGCAAGCAGCCCTGGTACCAGCTCTCCAACACGGAGGCAATCGACTGCATCACGCAGGGACG
TGAGTTGGAGCGGCCACGTGCCTGCCCACCAGAGGTCTACGCCATCATGCGGGGCTGCTGGCAGCGGGAGCCCCAGCAACGCCACAGCAT
CAAGGATGTGCACGCCCGGCTGCAAGCCCTGGCCCAGGCACCTCCTGTCTACCTGGATGTCCTGGGCTAGGGGGCCGGCCCAGGGGCTGG
GAGTGGTTAGCCGGAATACTGGGGCCTGCCCTCAGCATCCCCCATAGCTCCCAGCAGCCCCAGGGTGATCTCAAAGTATCTAATTCACCC
TCAGCATGTGGGAAGGGACAGGTGGGGGCTGGGAGTAGAGGATGTTCCTGCTTCTCTAGGCAAGGTCCCGTCATAGCAATTATATTTATT

>6265_6265_6_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000333972_NTRK1_chr1_156841415_ENST00000368196_length(amino acids)=920AA_BP=369
MKLGAGWGFSMKPPDRPAPGRTDRILGVMGGMLRACALPGQEGPPRRSPLGLVGTEPESERTEGDHRRDREHEVLAGALQPESYSIAGSE
GSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGP
GDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYF
LQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR
AGMDTADLEKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGS
VLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPF
GVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIK
RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGD
LNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGR
TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKD

--------------------------------------------------------------
>6265_6265_7_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000333972_NTRK1_chr1_156841415_ENST00000392302_length(transcript)=2922nt_BP=1114nt
CTCGACCCTGAAACTTGGAGCAGGGTGGGGGTTCAGTATGAAGCCCCCGGACCGCCCCGCCCCTGGCCGCACTGACCGGATACTGGGGGT
CATGGGGGGCATGCTGCGCGCATGCGCCCTCCCTGGGCAGGAGGGGCCCCCAAGGAGAAGCCCTCTAGGGTTGGTGGGTACCGAGCCAGA
GTCTGAACGTACGGAGGGAGATCACAGAAGGGATCGCGAACATGAGGTCCTCGCCGGGGCTCTGCAGCCCGAATCCTATTCCATTGCGGG
CAGTGAGGGGAGTATATCGGCTTCTGCTGCCTCCGGTCTGGCTGCCCCCTCTGGCCCCAGCTCTGGCCTCAGCTCTGGCCCCTGTTCCCC
AGGCCCCCCAGGGCCCGTCAGTGGCCTGAGGAGATGGTTGGATCATTCCAAACATTGTCTCAGTGTGGAAACTGAGGCAGACAGTGGTCA
GGCAGGACCATATGAGAACTGGATGTTGGAGCCAGCTCTAGCCACAGGAGAGGAGCTGCCGGAACTGACCTTGCTGACCACACTGTTGGA
GGGCCCTGGAGATAAGACGCAGCCACCTGAAGAGGAGACTTTGTCCCAAGCCCCTGAGAGTGAGGAGGAACAGAAGAAGAAGGCTCTGGA
AAGGAGTATGTATGTCCTGAGTGAACTGGTAGAAACAGAGAAAATGTACGTGGACGACTTGGGGCAGATTGTGGAGGGTTATATGGCCAC
CATGGCTGCTCAGGGGGTCCCCGAGAGTCTTCGAGGCCGTGACAGGATTGTGTTTGGGAATATCCAGCAAATCTATGAGTGGCACCGAGA
CTATTTCTTGCAAGAGCTACAACGGTGTCTGAAAGATCCTGATTGGCTGGCTCAGCTATTCATCAAACACGAGCGCCGGCTGCATATGTA
TGTGGTGTACTGTCAGAATAAGCCCAAGTCAGAGCATGTGGTGTCAGAGTTTGGGGACAGCTACTTTGAGGAGCTCCGGCAGCAGCTGGG
GCACCGCCTGCAGCTGAACGACCTCCTCATCAAACCTGTGCAGCGGATCATGAAATACCAGCTGCTGCTCAAGGATTTTCTCAAGTATTA
CAATAGAGCTGGGATGGATACTGCAGACCTAGAGAAATCTGGGGGTCTGCCATCCCTGGGGCTGACCCTGGCCAATGTCACCAGTGACCT
CAACAGGAAGAACGTGACGTGCTGGGCAGAGAACGATGTGGGCCGGGCAGAGGTCTCTGTTCAGGTCAACGTCTCCTTCCCGGCCAGTGT
GCAGCTGCACACGGCGGTGGAGATGCACCACTGGTGCATCCCCTTCTCTGTGGATGGGCAGCCGGCACCGTCTCTGCGCTGGCTCTTCAA
TGGCTCCGTGCTCAATGAGACCAGCTTCATCTTCACTGAGTTCCTGGAGCCGGCAGCCAATGAGACCGTGCGGCACGGGTGTCTGCGCCT
CAACCAGCCCACCCACGTCAACAACGGCAACTACACGCTGCTGGCTGCCAACCCCTTCGGCCAGGCCTCCGCCTCCATCATGGCTGCCTT
CATGGACAACCCTTTCGAGTTCAACCCCGAGGACCCCATCCCTGACACTAACAGCACATCTGGAGACCCGGTGGAGAAGAAGGACGAAAC
ACCTTTTGGGGTCTCGGTGGCTGTGGGCCTGGCCGTCTTTGCCTGCCTCTTCCTTTCTACGCTGCTCCTTGTGCTCAACAAATGTGGACG
GAGAAACAAGTTTGGGATCAACCGCCCGGCTGTGCTGGCTCCAGAGGATGGGCTGGCCATGTCCCTGCATTTCATGACATTGGGTGGCAG
CTCCCTGTCCCCCACCGAGGGCAAAGGCTCTGGGCTCCAAGGCCACATCATCGAGAACCCACAATACTTCAGTGATGCCTGTGTTCACCA
CATCAAGCGCCGGGACATCGTGCTCAAGTGGGAGCTGGGGGAGGGCGCCTTTGGGAAGGTCTTCCTTGCTGAGTGCCACAACCTCCTGCC
TGAGCAGGACAAGATGCTGGTGGCTGTCAAGGCACTGAAGGAGGCGTCCGAGAGTGCTCGGCAGGACTTCCAGCGTGAGGCTGAGCTGCT
CACCATGCTGCAGCACCAGCACATCGTGCGCTTCTTCGGCGTCTGCACCGAGGGCCGCCCCCTGCTCATGGTCTTTGAGTATATGCGGCA
CGGGGACCTCAACCGCTTCCTCCGATCCCATGGACCTGATGCCAAGCTGCTGGCTGGTGGGGAGGATGTGGCTCCAGGCCCCCTGGGTCT
GGGGCAGCTGCTGGCCGTGGCTAGCCAGGTCGCTGCGGGGATGGTGTACCTGGCGGGTCTGCATTTTGTGCACCGGGACCTGGCCACACG
CAACTGTCTAGTGGGCCAGGGACTGGTGGTCAAGATTGGTGATTTTGGCATGAGCAGGGATATCTACAGCACCGACTATTACCGTGTGGG
AGGCCGCACCATGCTGCCCATTCGCTGGATGCCGCCCGAGAGCATCCTGTACCGTAAGTTCACCACCGAGAGCGACGTGTGGAGCTTCGG
CGTGGTGCTCTGGGAGATCTTCACCTACGGCAAGCAGCCCTGGTACCAGCTCTCCAACACGGAGGCAATCGACTGCATCACGCAGGGACG
TGAGTTGGAGCGGCCACGTGCCTGCCCACCAGAGGTCTACGCCATCATGCGGGGCTGCTGGCAGCGGGAGCCCCAGCAACGCCACAGCAT
CAAGGATGTGCACGCCCGGCTGCAAGCCCTGGCCCAGGCACCTCCTGTCTACCTGGATGTCCTGGGCTAGGGGGCCGGCCCAGGGGCTGG
GAGTGGTTAGCCGGAATACTGGGGCCTGCCCTCAGCATCCCCCATAGCTCCCAGCAGCCCCAGGGTGATCTCAAAGTATCTAATTCACCC

>6265_6265_7_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000333972_NTRK1_chr1_156841415_ENST00000392302_length(amino acids)=920AA_BP=369
MKLGAGWGFSMKPPDRPAPGRTDRILGVMGGMLRACALPGQEGPPRRSPLGLVGTEPESERTEGDHRRDREHEVLAGALQPESYSIAGSE
GSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGP
GDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYF
LQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR
AGMDTADLEKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGS
VLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPF
GVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIK
RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGD
LNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGR
TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKD

--------------------------------------------------------------
>6265_6265_8_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000333972_NTRK1_chr1_156841415_ENST00000524377_length(transcript)=2788nt_BP=1114nt
CTCGACCCTGAAACTTGGAGCAGGGTGGGGGTTCAGTATGAAGCCCCCGGACCGCCCCGCCCCTGGCCGCACTGACCGGATACTGGGGGT
CATGGGGGGCATGCTGCGCGCATGCGCCCTCCCTGGGCAGGAGGGGCCCCCAAGGAGAAGCCCTCTAGGGTTGGTGGGTACCGAGCCAGA
GTCTGAACGTACGGAGGGAGATCACAGAAGGGATCGCGAACATGAGGTCCTCGCCGGGGCTCTGCAGCCCGAATCCTATTCCATTGCGGG
CAGTGAGGGGAGTATATCGGCTTCTGCTGCCTCCGGTCTGGCTGCCCCCTCTGGCCCCAGCTCTGGCCTCAGCTCTGGCCCCTGTTCCCC
AGGCCCCCCAGGGCCCGTCAGTGGCCTGAGGAGATGGTTGGATCATTCCAAACATTGTCTCAGTGTGGAAACTGAGGCAGACAGTGGTCA
GGCAGGACCATATGAGAACTGGATGTTGGAGCCAGCTCTAGCCACAGGAGAGGAGCTGCCGGAACTGACCTTGCTGACCACACTGTTGGA
GGGCCCTGGAGATAAGACGCAGCCACCTGAAGAGGAGACTTTGTCCCAAGCCCCTGAGAGTGAGGAGGAACAGAAGAAGAAGGCTCTGGA
AAGGAGTATGTATGTCCTGAGTGAACTGGTAGAAACAGAGAAAATGTACGTGGACGACTTGGGGCAGATTGTGGAGGGTTATATGGCCAC
CATGGCTGCTCAGGGGGTCCCCGAGAGTCTTCGAGGCCGTGACAGGATTGTGTTTGGGAATATCCAGCAAATCTATGAGTGGCACCGAGA
CTATTTCTTGCAAGAGCTACAACGGTGTCTGAAAGATCCTGATTGGCTGGCTCAGCTATTCATCAAACACGAGCGCCGGCTGCATATGTA
TGTGGTGTACTGTCAGAATAAGCCCAAGTCAGAGCATGTGGTGTCAGAGTTTGGGGACAGCTACTTTGAGGAGCTCCGGCAGCAGCTGGG
GCACCGCCTGCAGCTGAACGACCTCCTCATCAAACCTGTGCAGCGGATCATGAAATACCAGCTGCTGCTCAAGGATTTTCTCAAGTATTA
CAATAGAGCTGGGATGGATACTGCAGACCTAGAGAAATCTGGGGGTCTGCCATCCCTGGGGCTGACCCTGGCCAATGTCACCAGTGACCT
CAACAGGAAGAACGTGACGTGCTGGGCAGAGAACGATGTGGGCCGGGCAGAGGTCTCTGTTCAGGTCAACGTCTCCTTCCCGGCCAGTGT
GCAGCTGCACACGGCGGTGGAGATGCACCACTGGTGCATCCCCTTCTCTGTGGATGGGCAGCCGGCACCGTCTCTGCGCTGGCTCTTCAA
TGGCTCCGTGCTCAATGAGACCAGCTTCATCTTCACTGAGTTCCTGGAGCCGGCAGCCAATGAGACCGTGCGGCACGGGTGTCTGCGCCT
CAACCAGCCCACCCACGTCAACAACGGCAACTACACGCTGCTGGCTGCCAACCCCTTCGGCCAGGCCTCCGCCTCCATCATGGCTGCCTT
CATGGACAACCCTTTCGAGTTCAACCCCGAGGACCCCATCCCTGTCTCCTTCTCGCCGGTGGACACTAACAGCACATCTGGAGACCCGGT
GGAGAAGAAGGACGAAACACCTTTTGGGGTCTCGGTGGCTGTGGGCCTGGCCGTCTTTGCCTGCCTCTTCCTTTCTACGCTGCTCCTTGT
GCTCAACAAATGTGGACGGAGAAACAAGTTTGGGATCAACCGCCCGGCTGTGCTGGCTCCAGAGGATGGGCTGGCCATGTCCCTGCATTT
CATGACATTGGGTGGCAGCTCCCTGTCCCCCACCGAGGGCAAAGGCTCTGGGCTCCAAGGCCACATCATCGAGAACCCACAATACTTCAG
TGATGCCTGTGTTCACCACATCAAGCGCCGGGACATCGTGCTCAAGTGGGAGCTGGGGGAGGGCGCCTTTGGGAAGGTCTTCCTTGCTGA
GTGCCACAACCTCCTGCCTGAGCAGGACAAGATGCTGGTGGCTGTCAAGGCACTGAAGGAGGCGTCCGAGAGTGCTCGGCAGGACTTCCA
GCGTGAGGCTGAGCTGCTCACCATGCTGCAGCACCAGCACATCGTGCGCTTCTTCGGCGTCTGCACCGAGGGCCGCCCCCTGCTCATGGT
CTTTGAGTATATGCGGCACGGGGACCTCAACCGCTTCCTCCGATCCCATGGACCTGATGCCAAGCTGCTGGCTGGTGGGGAGGATGTGGC
TCCAGGCCCCCTGGGTCTGGGGCAGCTGCTGGCCGTGGCTAGCCAGGTCGCTGCGGGGATGGTGTACCTGGCGGGTCTGCATTTTGTGCA
CCGGGACCTGGCCACACGCAACTGTCTAGTGGGCCAGGGACTGGTGGTCAAGATTGGTGATTTTGGCATGAGCAGGGATATCTACAGCAC
CGACTATTACCGTGTGGGAGGCCGCACCATGCTGCCCATTCGCTGGATGCCGCCCGAGAGCATCCTGTACCGTAAGTTCACCACCGAGAG
CGACGTGTGGAGCTTCGGCGTGGTGCTCTGGGAGATCTTCACCTACGGCAAGCAGCCCTGGTACCAGCTCTCCAACACGGAGGCAATCGA
CTGCATCACGCAGGGACGTGAGTTGGAGCGGCCACGTGCCTGCCCACCAGAGGTCTACGCCATCATGCGGGGCTGCTGGCAGCGGGAGCC

>6265_6265_8_ARHGEF25-NTRK1_ARHGEF25_chr12_58008800_ENST00000333972_NTRK1_chr1_156841415_ENST00000524377_length(amino acids)=927AA_BP=369
MKLGAGWGFSMKPPDRPAPGRTDRILGVMGGMLRACALPGQEGPPRRSPLGLVGTEPESERTEGDHRRDREHEVLAGALQPESYSIAGSE
GSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGP
GDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYF
LQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR
AGMDTADLEKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGS
VLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEK
KDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDA
CVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFE
YMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY
YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGEF25-NTRK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNTRK1chr12:58008800chr1:156841415ENST00000368196516469_490239.0791.0SQSTM1
TgeneNTRK1chr12:58008800chr1:156841415ENST00000392302617469_490209.0761.0SQSTM1
TgeneNTRK1chr12:58008800chr1:156841415ENST00000524377517469_490239.0797.0SQSTM1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF25-NTRK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF25-NTRK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource