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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:PARD3B-TACC1 (FusionGDB2 ID:62689) |
Fusion Gene Summary for PARD3B-TACC1 |
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Fusion gene information | Fusion gene name: PARD3B-TACC1 | Fusion gene ID: 62689 | Hgene | Tgene | Gene symbol | PARD3B | TACC1 | Gene ID | 117583 | 6867 |
Gene name | par-3 family cell polarity regulator beta | transforming acidic coiled-coil containing protein 1 | |
Synonyms | ALS2CR19|PAR3B|PAR3L|PAR3beta | Ga55 | |
Cytomap | 2q33.3 | 8p11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | partitioning defective 3 homolog BPAR3-L proteinamyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 19amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 proteinpar-3 partitioning defective 3 homolog Bpartitioning | transforming acidic coiled-coil-containing protein 1gastric cancer antigen Ga55taxin-1 | |
Modification date | 20200313 | 20200320 | |
UniProtAcc | . | O75410 | |
Ensembl transtripts involved in fusion gene | ENST00000349953, ENST00000351153, ENST00000358768, ENST00000406610, ENST00000462231, ENST00000488622, | ENST00000443286, ENST00000518415, ENST00000519416, ENST00000520340, ENST00000520615, ENST00000520973, ENST00000276520, ENST00000317827, ENST00000330691, ENST00000348567, ENST00000379931, ENST00000520611, ENST00000522752, | |
Fusion gene scores | * DoF score | 18 X 15 X 9=2430 | 18 X 21 X 10=3780 |
# samples | 20 | 23 | |
** MAII score | log2(20/2430*10)=-3.60288440871842 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(23/3780*10)=-4.03868046816406 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PARD3B [Title/Abstract] AND TACC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | PARD3B(205551005)-TACC1(38677040), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | PRAD | TCGA-CH-5794-01A | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
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Fusion Gene ORF analysis for PARD3B-TACC1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000349953 | ENST00000443286 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000349953 | ENST00000518415 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000349953 | ENST00000519416 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000349953 | ENST00000520340 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000349953 | ENST00000520615 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000349953 | ENST00000520973 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000351153 | ENST00000443286 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000351153 | ENST00000518415 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000351153 | ENST00000519416 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000351153 | ENST00000520340 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000351153 | ENST00000520615 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000351153 | ENST00000520973 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000358768 | ENST00000443286 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000358768 | ENST00000518415 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000358768 | ENST00000519416 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000358768 | ENST00000520340 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000358768 | ENST00000520615 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000358768 | ENST00000520973 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000406610 | ENST00000443286 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000406610 | ENST00000518415 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000406610 | ENST00000519416 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000406610 | ENST00000520340 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000406610 | ENST00000520615 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000406610 | ENST00000520973 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000462231 | ENST00000443286 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000462231 | ENST00000518415 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000462231 | ENST00000519416 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000462231 | ENST00000520340 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000462231 | ENST00000520615 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-5UTR | ENST00000462231 | ENST00000520973 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000349953 | ENST00000276520 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000349953 | ENST00000317827 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000349953 | ENST00000330691 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000349953 | ENST00000348567 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000349953 | ENST00000379931 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000349953 | ENST00000520611 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000349953 | ENST00000522752 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000351153 | ENST00000276520 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000351153 | ENST00000317827 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000351153 | ENST00000330691 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000351153 | ENST00000348567 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000351153 | ENST00000379931 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000351153 | ENST00000520611 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000351153 | ENST00000522752 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000358768 | ENST00000276520 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000358768 | ENST00000317827 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000358768 | ENST00000330691 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000358768 | ENST00000348567 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000358768 | ENST00000379931 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000358768 | ENST00000520611 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000358768 | ENST00000522752 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000406610 | ENST00000276520 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000406610 | ENST00000317827 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000406610 | ENST00000330691 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000406610 | ENST00000348567 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000406610 | ENST00000379931 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000406610 | ENST00000520611 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000406610 | ENST00000522752 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000462231 | ENST00000276520 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000462231 | ENST00000317827 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000462231 | ENST00000330691 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000462231 | ENST00000348567 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000462231 | ENST00000379931 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000462231 | ENST00000520611 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
5CDS-intron | ENST00000462231 | ENST00000522752 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
intron-5UTR | ENST00000488622 | ENST00000443286 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
intron-5UTR | ENST00000488622 | ENST00000518415 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
intron-5UTR | ENST00000488622 | ENST00000519416 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
intron-5UTR | ENST00000488622 | ENST00000520340 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
intron-5UTR | ENST00000488622 | ENST00000520615 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
intron-5UTR | ENST00000488622 | ENST00000520973 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
intron-intron | ENST00000488622 | ENST00000276520 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
intron-intron | ENST00000488622 | ENST00000317827 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
intron-intron | ENST00000488622 | ENST00000330691 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
intron-intron | ENST00000488622 | ENST00000348567 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
intron-intron | ENST00000488622 | ENST00000379931 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
intron-intron | ENST00000488622 | ENST00000520611 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
intron-intron | ENST00000488622 | ENST00000522752 | PARD3B | chr2 | 205551005 | - | TACC1 | chr8 | 38677040 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for PARD3B-TACC1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for PARD3B-TACC1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:205551005/:38677040) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | TACC1 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for PARD3B-TACC1 |
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Fusion Gene PPI Analysis for PARD3B-TACC1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PARD3B-TACC1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PARD3B-TACC1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |