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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PARD3-HTRA1 (FusionGDB2 ID:62708)

Fusion Gene Summary for PARD3-HTRA1

check button Fusion gene summary
Fusion gene informationFusion gene name: PARD3-HTRA1
Fusion gene ID: 62708
HgeneTgene
Gene symbol

PARD3

HTRA1

Gene ID

56288

5654

Gene namepar-3 family cell polarity regulatorHtrA serine peptidase 1
SynonymsASIP|Baz|PAR3|PAR3alpha|PARD-3|PARD3A|PPP1R118|SE2-5L16|SE2-5LT1|SE2-5T2ARMD7|CADASIL2|CARASIL|HtrA|L56|ORF480|PRSS11
Cytomap

10p11.22-p11.21

10q26.13

Type of geneprotein-codingprotein-coding
Descriptionpartitioning defective 3 homologCTCL tumor antigen se2-5PAR3-alphaatypical PKC isotype-specific interacting proteinbazookapar-3 family cell polarity regulator alphapar-3 partitioning defective 3 homologprotein phosphatase 1, regulatory subunit 118serine protease HTRA1IGFBP5-proteasehigh-temperature requirement A serine peptidase 1protease, serine, 11 (IGF binding)
Modification date2020032720200322
UniProtAcc.

Q92743

Ensembl transtripts involved in fusion geneENST00000466092, ENST00000544292, 
ENST00000340077, ENST00000346874, 
ENST00000350537, ENST00000374773, 
ENST00000374776, ENST00000374788, 
ENST00000374789, ENST00000374790, 
ENST00000374794, ENST00000545260, 
ENST00000545693, ENST00000374768, 
ENST00000368984, 
Fusion gene scores* DoF score33 X 20 X 14=92404 X 5 X 4=80
# samples 495
** MAII scorelog2(49/9240*10)=-4.23703919730085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PARD3 [Title/Abstract] AND HTRA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPARD3(34620045)-HTRA1(124248418), # samples:1
Anticipated loss of major functional domain due to fusion event.PARD3-HTRA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PARD3-HTRA1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PARD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HTRA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-6953-01APARD3chr10

34620045

-HTRA1chr10

124248418

+


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Fusion Gene ORF analysis for PARD3-HTRA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000466092ENST00000368984PARD3chr10

34620045

-HTRA1chr10

124248418

+
Frame-shiftENST00000544292ENST00000368984PARD3chr10

34620045

-HTRA1chr10

124248418

+
In-frameENST00000340077ENST00000368984PARD3chr10

34620045

-HTRA1chr10

124248418

+
In-frameENST00000346874ENST00000368984PARD3chr10

34620045

-HTRA1chr10

124248418

+
In-frameENST00000350537ENST00000368984PARD3chr10

34620045

-HTRA1chr10

124248418

+
In-frameENST00000374773ENST00000368984PARD3chr10

34620045

-HTRA1chr10

124248418

+
In-frameENST00000374776ENST00000368984PARD3chr10

34620045

-HTRA1chr10

124248418

+
In-frameENST00000374788ENST00000368984PARD3chr10

34620045

-HTRA1chr10

124248418

+
In-frameENST00000374789ENST00000368984PARD3chr10

34620045

-HTRA1chr10

124248418

+
In-frameENST00000374790ENST00000368984PARD3chr10

34620045

-HTRA1chr10

124248418

+
In-frameENST00000374794ENST00000368984PARD3chr10

34620045

-HTRA1chr10

124248418

+
In-frameENST00000545260ENST00000368984PARD3chr10

34620045

-HTRA1chr10

124248418

+
In-frameENST00000545693ENST00000368984PARD3chr10

34620045

-HTRA1chr10

124248418

+
intron-3CDSENST00000374768ENST00000368984PARD3chr10

34620045

-HTRA1chr10

124248418

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545260PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4422290219838721224
ENST00000545693PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4644312419840941298
ENST00000350537PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4550303019440001268
ENST00000346874PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4688316819441381314
ENST00000374789PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4688316819441381314
ENST00000374790PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4508298819439581254
ENST00000374794PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4463294319439131239
ENST00000374788PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4679315919441291311
ENST00000374776PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4550303019440001268
ENST00000340077PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4683316319841331311
ENST00000374773PARD3chr1034620045-ENST00000368984HTRA1chr10124248418+4589306919440391281

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545260ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0016074040.9983925
ENST00000545693ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0015035810.9984964
ENST00000350537ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0014372760.99856275
ENST00000346874ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0015807660.9984193
ENST00000374789ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0015807660.9984193
ENST00000374790ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0015947610.9984053
ENST00000374794ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0012658220.9987342
ENST00000374788ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0019236080.99807644
ENST00000374776ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0014372760.99856275
ENST00000340077ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.001911380.99808854
ENST00000374773ENST00000368984PARD3chr1034620045-HTRA1chr10124248418+0.0012911250.99870884

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Fusion Genomic Features for PARD3-HTRA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PARD3chr1034620044-HTRA1chr10124248417+3.70E-091
PARD3chr1034620044-HTRA1chr10124248417+3.70E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PARD3-HTRA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:34620045/chr10:124248418)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HTRA1

Q92743

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. {ECO:0000269|PubMed:16377621, ECO:0000269|PubMed:20671064, ECO:0000269|PubMed:9852107}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-1921271_3599441032.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-1921461_5469441032.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-1921590_6779441032.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-1924271_3599471320.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-1924461_5469471320.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-1924590_6779471320.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-1824271_3599011311.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-1824461_5469011311.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-1824590_6779011311.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-1820271_359901989.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-1820461_546901989.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-1820590_677901989.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-1925271_3599441354.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-1925461_5469441354.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-1925590_6779441354.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-1925271_3599471357.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-1925461_5469471357.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-1925590_6779471357.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-1621271_3598721245.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-1621461_5468721245.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-1621590_6778721245.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-1723271_3598571267.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-1723461_5468571267.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-1723590_6778571267.0DomainPDZ 3
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-1824271_3599311341.0DomainPDZ 1
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-1824461_5469311341.0DomainPDZ 2
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-1824590_6779311341.0DomainPDZ 3
TgeneHTRA1chr10:34620045chr10:124248418ENST0000036898409365_467157481.0DomainPDZ
TgeneHTRA1chr10:34620045chr10:124248418ENST0000036898409204_364157481.0RegionNote=Serine protease

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-19211049_10779441032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-19211151_11749441032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-19211201_12249441032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-19211280_13019441032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-19241049_10779471320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-19241151_11749471320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-19241201_12249471320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-19241280_13019471320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-18241049_10779011311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-18241151_11749011311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-18241201_12249011311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-18241280_13019011311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-18201049_1077901989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-18201151_1174901989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-18201201_1224901989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-18201280_1301901989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-19251049_10779441354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-19251151_11749441354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-19251201_12249441354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-19251280_13019441354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-19251049_10779471357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-19251151_11749471357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-19251201_12249471357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-19251280_13019471357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-16211049_10778721245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-16211151_11748721245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-16211201_12248721245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-16211280_13018721245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-17231049_10778571267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-17231151_11748571267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-17231201_12248571267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-17231280_13018571267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-18241049_10779311341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-18241151_11749311341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-18241201_12249311341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-18241280_13019311341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-1921984_10429441032.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-1924984_10429471320.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-1824984_10429011311.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-1820984_1042901989.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-1925984_10429441354.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-1925984_10429471357.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-1621984_10428721245.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-1723984_10428571267.0Compositional biasNote=Lys-rich
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-1824984_10429311341.0Compositional biasNote=Lys-rich
TgeneHTRA1chr10:34620045chr10:124248418ENST000003689840933_100157481.0DomainIGFBP N-terminal
TgeneHTRA1chr10:34620045chr10:124248418ENST000003689840998_157157481.0DomainKazal-like


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Fusion Gene Sequence for PARD3-HTRA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>62708_62708_1_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000340077_HTRA1_chr10_124248418_ENST00000368984_length(transcript)=4683nt_BP=3163nt
CCCAGCGGCCCCGAGCGAGCGCCAGCGCCACACAGCCCCGGGCAGCCGCCGGCGAGCGCGCCGCGACGCCGAACAGGTGGCCGGAGGCTG
CGGGCGCCGCGGCGGGGAGAGGCGAGGCAAGCCCCGGGCGAAGCGAGGCGAGGCGAGGGCGGCCGGGCCGGGCATGCGAGCTGAGCGGCC
CCCCGGCGTCGCCGCCGCCTGCCCGCGCCCCTAGCCGCCCGCGCGCCCGAGTCCCCAGCGGCTCCTCCGCGCCCAGCGTCCTCGGTCCCG
GCCTCGGCTGCTCCGGCTGCGCTCGGCGAGGGGCGCGGGCCCGCCCGCGGCGGCGGCGGCATGAAAGTGACCGTGTGCTTCGGACGGACC
CGGGTGGTCGTGCCGTGCGGGGACGGCCACATGAAAGTTTTCAGCCTCATCCAGCAGGCGGTGACCCGCTACCGGAAGGCCATCGCCAAG
GATCCAAACTACTGGATACAGGTGCATCGCTTGGAACATGGAGATGGAGGAATACTAGACCTTGATGACATTCTTTGTGATGTAGCAGAC
GATAAAGACAGACTGGTAGCAGTGTTTGATGAGCAGGATCCACATCACGGAGGTGATGGCACCAGTGCCAGTTCCACGGGTACCCAGAGC
CCAGAGATATTTGGTAGTGAGCTTGGCACCAACAATGTCTCAGCCTTTCAGCCTTACCAAGCAACAAGTGAAATTGAGGTCACACCTTCA
GTCCTTCGAGCAAATATGCCTCTTCATGTTCGACGCAGTAGTGACCCAGCTCTAATTGGCCTCTCCACTTCTGTCAGTGATAGTAATTTT
TCCTCTGAAGAGCCTTCAAGGAAAAATCCCACACGCTGGTCAACAACAGCTGGCTTCCTCAAGCAGAACACTGCTGGGAGTCCTAAAACC
TGCGACAGGAAGAAAGATGAAAACTACAGAAGCCTCCCGCGGGATACTAGTAACTGGTCTAACCAATTTCAGAGAGACAATGCTCGCTCG
TCTCTGAGTGCCAGTCACCCAATGGTGGGCAAGTGGCTGGAGAAACAAGAACAGGATGAGGATGGGACAGAAGAGGATAACAGTCGTGTT
GAACCTGTTGGACATGCTGACACGGGTTTGGAGCATATACCCAACTTTTCTCTGGATGATATGGTAAAGCTCGTAGAAGTCCCCAACGAT
GGAGGGCCTCTGGGAATCCACGTAGTGCCTTTCAGTGCTCGAGGCGGCAGAACCCTGGGGTTATTAGTAAAACGATTGGAGAAAGGTGGT
AAAGCTGAACATGAAAATCTTTTTCGTGAGAATGATTGCATTGTCAGGATTAATGATGGCGACCTTCGAAATAGAAGATTTGAACAAGCA
CAACATATGTTTCGCCAAGCCATGCGTACACCCATCATTTGGTTCCATGTGGTTCCTGCAGCAAATAAAGAGCAGTATGAACAACTATCC
CAAAGTGAGAAGAACAATTACTATTCAAGCCGTTTTAGCCCTGACAGCCAGTATATTGACAACAGGAGTGTGAACAGTGCAGGGCTTCAC
ACGGTGCAGAGAGCACCCCGACTGAACCACCCGCCTGAGCAGATAGACTCTCACTCAAGACTACCTCATAGCGCACACCCCTCGGGAAAA
CCACCATCCGCTCCAGCCTCGGCACCTCAGAATGTATTTAGTACGACTGTAAGCAGTGGTTATAACACCAAAAAAATAGGCAAGAGGCTT
AATATCCAGCTTAAGAAAGGTACAGAAGGTTTGGGATTCAGCATCACTTCCAGAGATGTAACAATAGGTGGCTCAGCTCCAATCTATGTG
AAAAACATTCTCCCCCGGGGGGCGGCCATTCAGGATGGCCGACTTAAGGCAGGAGACAGACTTATAGAGGTAAATGGAGTAGATTTAGTG
GGCAAATCCCAAGAGGAAGTTGTTTCGCTGTTGAGAAGCACCAAGATGGAAGGAACTGTGAGCCTTCTGGTCTTTCGCCAGGAAGACGCC
TTCCACCCAAGGGAACTGAATGCAGAGCCAAGCCAGATGCAGATTCCAAAAGAAACGAAAGCAGAAGATGAGGATATTGTTCTTACACCT
GATGGCACCAGGGAATTTCTGACATTTGAAGTCCCACTTAATGATTCAGGATCTGCAGGCCTTGGTGTCAGTGTCAAAGGTAACCGGTCA
AAAGAGAACCACGCAGATTTGGGAATCTTTGTCAAGTCCATTATTAATGGAGGAGCAGCATCTAAAGATGGAAGGCTTCGGGTGAATGAT
CAACTGATAGCAGTAAATGGAGAATCCCTGTTGGGCAAGACAAACCAAGATGCCATGGAAACCCTAAGAAGGTCTATGTCTACTGAAGGC
AATAAACGAGGAATGATCCAGCTTATTGTTGCAAGGAGAATAAGCAAGTGCAATGAGCTGAAGTCACCTGGGAGCCCCCCTGGACCTGAG
CTGCCCATTGAAACAGCGTTGGATGATAGAGAACGAAGAATTTCCCATTCCCTCTACAGTGGGATTGAGGGGCTTGATGAATCGCCCAGC
AGAAATGCTGCCCTCAGTAGGATAATGGGTAAATACCAGCTGTCCCCTACAGTGAATATGCCCCAAGATGACACTGTCATTATAGAAGAT
GACAGGTTGCCAGTGCTTCCTCCACATCTCTCTGACCAGTCCTCTTCCAGCTCCCATGATGATGTGGGGTTTGTGACGGCAGATGCTGGT
ACTTGGGCCAAGGCTGCAATCAGTGATTCAGCCGACTGCTCTTTGAGTCCAGATGTTGATCCAGTTCTTGCTTTTCAACGAGAAGGATTT
GGACGTCAGAGTATGTCAGAAAAACGCACAAAGCAATTTTCAGATGCCAGTCAATTGGATTTCGTTAAAACACGAAAATCAAAAAGCATG
GATTTAGGTATAGCTGACGAGACTAAACTCAATACAGTGGATGACCAGAAAGCAGGTTCTCCCAGCAGAGATGTGGGTCCTTCCCTGGGT
CTGAAGAAGTCAAGCTCGTTGGAGAGTCTGCAGACCGCAGTTGCCGAGGTGACTTTGAATGGGGATATTCCTTTCCATCGTCCACGGCCG
CGGATAATCAGAGGCAGGGGATGCAATGAGAGCTTCAGAGCTGCCATCGACAAATCTTATGATAAACCCGCGGTAGATGATGATGATGAA
GGCATGGAGACCTGGCAGGAAGATCCCAACAGTTTGCGCCATAAATATAACTTTATCGCGGACGTGGTGGAGAAGATCGCCCCTGCCGTG
GTTCATATCGAATTGTTTCGCAAGCTTCCGTTTTCTAAACGAGAGGTGCCGGTGGCTAGTGGGTCTGGGTTTATTGTGTCGGAAGATGGA
CTGATCGTGACAAATGCCCACGTGGTGACCAACAAGCACCGGGTCAAAGTTGAGCTGAAGAACGGTGCCACTTACGAAGCCAAAATCAAG
GATGTGGATGAGAAAGCAGACATCGCACTCATCAAAATTGACCACCAGGGCAAGCTGCCTGTCCTGCTGCTTGGCCGCTCCTCAGAGCTG
CGGCCGGGAGAGTTCGTGGTCGCCATCGGAAGCCCGTTTTCCCTTCAAAACACAGTCACCACCGGGATCGTGAGCACCACCCAGCGAGGC
GGCAAAGAGCTGGGGCTCCGCAACTCAGACATGGACTACATCCAGACCGACGCCATCATCAACTATGGAAACTCGGGAGGCCCGTTAGTA
AACCTGGACGGTGAAGTGATTGGAATTAACACTTTGAAAGTGACAGCTGGAATCTCCTTTGCAATCCCATCTGATAAGATTAAAAAGTTC
CTCACGGAGTCCCATGACCGACAGGCCAAAGGAAAAGCCATCACCAAGAAGAAGTATATTGGTATCCGAATGATGTCACTCACGTCCAGC
AAAGCCAAAGAGCTGAAGGACCGGCACCGGGACTTCCCAGACGTGATCTCAGGAGCGTATATAATTGAAGTAATTCCTGATACCCCAGCA
GAAGCTGGTGGTCTCAAGGAAAACGACGTCATAATCAGCATCAATGGACAGTCCGTGGTCTCCGCCAATGATGTCAGCGACGTCATTAAA
AGGGAAAGCACCCTGAACATGGTGGTCCGCAGGGGTAATGAAGATATCATGATCACAGTGATTCCCGAAGAAATTGACCCATAGGCAGAG
GCATGAGCTGGACTTCATGTTTCCCTCAAAGACTCTCCCGTGGATGACGGATGAGGACTCTGGGCTGCTGGAATAGGACACTCAAGACTT
TTGACTGCCATTTTGTTTGTTCAGTGGAGACTCCCTGGCCAACAGAATCCTTCTTGATAGTTTGCAGGCAAAACAAATGTAATGTTGCAG
ATCCGCAGGCAGAAGCTCTGCCCTTCTGTATCCTATGTATGCAGTGTGCTTTTTCTTGCCAGCTTGGGCCATTCTTGCTTAGACAGTCAG
CATTTGTCTCCTCCTTTAACTGAGTCATCATCTTAGTCCAACTAATGCAGTCGATACAATGCGTAGATAGAAGAAGCCCCACGGGAGCCA
GGATGGGACTGGTCGTGTTTGTGCTTTTCTCCAAGTCAGCACCCAAAGGTCAATGCACAGAGACCCCGGGTGGGTGAGCGCTGGCTTCTC
AAACGGCCGAAGTTGCCTCTTTTAGGAATCTCTTTGGAATTGGGAGCACGATGACTCTGAGTTTGAGCTATTAAAGTACTTCTTACACAT

>62708_62708_1_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000340077_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1311AA_BP=989
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREF
LTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMI
QLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVL
PPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIAD
ETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETWQ
EDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKA
DIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEV
IGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLK

--------------------------------------------------------------
>62708_62708_2_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000346874_HTRA1_chr10_124248418_ENST00000368984_length(transcript)=4688nt_BP=3168nt
GCGGCCCCGAGCGAGCGCCAGCGCCACACAGCCCCGGGCAGCCGCCGGCGAGCGCGCCGCGACGCCGAACAGGTGGCCGGAGGCTGCGGG
CGCCGCGGCGGGGAGAGGCGAGGCAAGCCCCGGGCGAAGCGAGGCGAGGCGAGGGCGGCCGGGCCGGGCATGCGAGCTGAGCGGCCCCCC
GGCGTCGCCGCCGCCTGCCCGCGCCCCTAGCCGCCCGCGCGCCCGAGTCCCCAGCGGCTCCTCCGCGCCCAGCGTCCTCGGTCCCGGCCT
CGGCTGCTCCGGCTGCGCTCGGCGAGGGGCGCGGGCCCGCCCGCGGCGGCGGCGGCATGAAAGTGACCGTGTGCTTCGGACGGACCCGGG
TGGTCGTGCCGTGCGGGGACGGCCACATGAAAGTTTTCAGCCTCATCCAGCAGGCGGTGACCCGCTACCGGAAGGCCATCGCCAAGGATC
CAAACTACTGGATACAGGTGCATCGCTTGGAACATGGAGATGGAGGAATACTAGACCTTGATGACATTCTTTGTGATGTAGCAGACGATA
AAGACAGACTGGTAGCAGTGTTTGATGAGCAGGATCCACATCACGGAGGTGATGGCACCAGTGCCAGTTCCACGGGTACCCAGAGCCCAG
AGATATTTGGTAGTGAGCTTGGCACCAACAATGTCTCAGCCTTTCAGCCTTACCAAGCAACAAGTGAAATTGAGGTCACACCTTCAGTCC
TTCGAGCAAATATGCCTCTTCATGTTCGACGCAGTAGTGACCCAGCTCTAATTGGCCTCTCCACTTCTGTCAGTGATAGTAATTTTTCCT
CTGAAGAGCCTTCAAGGAAAAATCCCACACGCTGGTCAACAACAGCTGGCTTCCTCAAGCAGAACACTGCTGGGAGTCCTAAAACCTGCG
ACAGGAAGAAAGATGAAAACTACAGAAGCCTCCCGCGGGATACTAGTAACTGGTCTAACCAATTTCAGAGAGACAATGCTCGCTCGTCTC
TGAGTGCCAGTCACCCAATGGTGGGCAAGTGGCTGGAGAAACAAGAACAGGATGAGGATGGGACAGAAGAGGATAACAGTCGTGTTGAAC
CTGTTGGACATGCTGACACGGGTTTGGAGCATATACCCAACTTTTCTCTGGATGATATGGTAAAGCTCGTAGAAGTCCCCAACGATGGAG
GGCCTCTGGGAATCCACGTAGTGCCTTTCAGTGCTCGAGGCGGCAGAACCCTGGGGTTATTAGTAAAACGATTGGAGAAAGGTGGTAAAG
CTGAACATGAAAATCTTTTTCGTGAGAATGATTGCATTGTCAGGATTAATGATGGCGACCTTCGAAATAGAAGATTTGAACAAGCACAAC
ATATGTTTCGCCAAGCCATGCGTACACCCATCATTTGGTTCCATGTGGTTCCTGCAGCAAATAAAGAGCAGTATGAACAACTATCCCAAA
GTGAGAAGAACAATTACTATTCAAGCCGTTTTAGCCCTGACAGCCAGTATATTGACAACAGGAGTGTGAACAGTGCAGGGCTTCACACGG
TGCAGAGAGCACCCCGACTGAACCACCCGCCTGAGCAGATAGACTCTCACTCAAGACTACCTCATAGCGCACACCCCTCGGGAAAACCAC
CATCCGCTCCAGCCTCGGCACCTCAGAATGTATTTAGTACGACTGTAAGCAGTGGTTATAACACCAAAAAAATAGGCAAGAGGCTTAATA
TCCAGCTTAAGAAAGGTACAGAAGGTTTGGGATTCAGCATCACTTCCAGAGATGTAACAATAGGTGGCTCAGCTCCAATCTATGTGAAAA
ACATTCTCCCCCGGGGGGCGGCCATTCAGGATGGCCGACTTAAGGCAGGAGACAGACTTATAGAGGTAAATGGAGTAGATTTAGTGGGCA
AATCCCAAGAGGAAGTTGTTTCGCTGTTGAGAAGCACCAAGATGGAAGGAACTGTGAGCCTTCTGGTCTTTCGCCAGGAAGACGCCTTCC
ACCCAAGGGAACTGAATGCAGAGCCAAGCCAGATGCAGATTCCAAAAGAAACGAAAGCAGAAGATGAGGATATTGTTCTTACACCTGATG
GCACCAGGGAATTTCTGACATTTGAAGTCCCACTTAATGATTCAGGATCTGCAGGCCTTGGTGTCAGTGTCAAAGGTAACCGGTCAAAAG
AGAACCACGCAGATTTGGGAATCTTTGTCAAGTCCATTATTAATGGAGGAGCAGCATCTAAAGATGGAAGGCTTCGGGTGAATGATCAAC
TGATAGCAGTAAATGGAGAATCCCTGTTGGGCAAGACAAACCAAGATGCCATGGAAACCCTAAGAAGGTCTATGTCTACTGAAGGCAATA
AACGAGGAATGATCCAGCTTATTGTTGCAAGGAGAATAAGCAAGTGCAATGAGCTGAAGTCACCTGGGAGCCCCCCTGGACCTGAGCTGC
CCATTGAAACAGCGTTGGATGATAGAGAACGAAGAATTTCCCATTCCCTCTACAGTGGGATTGAGGGGCTTGATGAATCGCCCAGCAGAA
ATGCTGCCCTCAGTAGGATAATGGGTGAGTCAGGTAAATACCAGCTGTCCCCTACAGTGAATATGCCCCAAGATGACACTGTCATTATAG
AAGATGACAGGTTGCCAGTGCTTCCTCCACATCTCTCTGACCAGTCCTCTTCCAGCTCCCATGATGATGTGGGGTTTGTGACGGCAGATG
CTGGTACTTGGGCCAAGGCTGCAATCAGTGATTCAGCCGACTGCTCTTTGAGTCCAGATGTTGATCCAGTTCTTGCTTTTCAACGAGAAG
GATTTGGACGTCAGAGTATGTCAGAAAAACGCACAAAGCAATTTTCAGATGCCAGTCAATTGGATTTCGTTAAAACACGAAAATCAAAAA
GCATGGATTTAGGTATAGCTGACGAGACTAAACTCAATACAGTGGATGACCAGAAAGCAGGTTCTCCCAGCAGAGATGTGGGTCCTTCCC
TGGGTCTGAAGAAGTCAAGCTCGTTGGAGAGTCTGCAGACCGCAGTTGCCGAGGTGACTTTGAATGGGGATATTCCTTTCCATCGTCCAC
GGCCGCGGATAATCAGAGGCAGGGGATGCAATGAGAGCTTCAGAGCTGCCATCGACAAATCTTATGATAAACCCGCGGTAGATGATGATG
ATGAAGGCATGGAGACCTGGCAGGAAGATCCCAACAGTTTGCGCCATAAATATAACTTTATCGCGGACGTGGTGGAGAAGATCGCCCCTG
CCGTGGTTCATATCGAATTGTTTCGCAAGCTTCCGTTTTCTAAACGAGAGGTGCCGGTGGCTAGTGGGTCTGGGTTTATTGTGTCGGAAG
ATGGACTGATCGTGACAAATGCCCACGTGGTGACCAACAAGCACCGGGTCAAAGTTGAGCTGAAGAACGGTGCCACTTACGAAGCCAAAA
TCAAGGATGTGGATGAGAAAGCAGACATCGCACTCATCAAAATTGACCACCAGGGCAAGCTGCCTGTCCTGCTGCTTGGCCGCTCCTCAG
AGCTGCGGCCGGGAGAGTTCGTGGTCGCCATCGGAAGCCCGTTTTCCCTTCAAAACACAGTCACCACCGGGATCGTGAGCACCACCCAGC
GAGGCGGCAAAGAGCTGGGGCTCCGCAACTCAGACATGGACTACATCCAGACCGACGCCATCATCAACTATGGAAACTCGGGAGGCCCGT
TAGTAAACCTGGACGGTGAAGTGATTGGAATTAACACTTTGAAAGTGACAGCTGGAATCTCCTTTGCAATCCCATCTGATAAGATTAAAA
AGTTCCTCACGGAGTCCCATGACCGACAGGCCAAAGGAAAAGCCATCACCAAGAAGAAGTATATTGGTATCCGAATGATGTCACTCACGT
CCAGCAAAGCCAAAGAGCTGAAGGACCGGCACCGGGACTTCCCAGACGTGATCTCAGGAGCGTATATAATTGAAGTAATTCCTGATACCC
CAGCAGAAGCTGGTGGTCTCAAGGAAAACGACGTCATAATCAGCATCAATGGACAGTCCGTGGTCTCCGCCAATGATGTCAGCGACGTCA
TTAAAAGGGAAAGCACCCTGAACATGGTGGTCCGCAGGGGTAATGAAGATATCATGATCACAGTGATTCCCGAAGAAATTGACCCATAGG
CAGAGGCATGAGCTGGACTTCATGTTTCCCTCAAAGACTCTCCCGTGGATGACGGATGAGGACTCTGGGCTGCTGGAATAGGACACTCAA
GACTTTTGACTGCCATTTTGTTTGTTCAGTGGAGACTCCCTGGCCAACAGAATCCTTCTTGATAGTTTGCAGGCAAAACAAATGTAATGT
TGCAGATCCGCAGGCAGAAGCTCTGCCCTTCTGTATCCTATGTATGCAGTGTGCTTTTTCTTGCCAGCTTGGGCCATTCTTGCTTAGACA
GTCAGCATTTGTCTCCTCCTTTAACTGAGTCATCATCTTAGTCCAACTAATGCAGTCGATACAATGCGTAGATAGAAGAAGCCCCACGGG
AGCCAGGATGGGACTGGTCGTGTTTGTGCTTTTCTCCAAGTCAGCACCCAAAGGTCAATGCACAGAGACCCCGGGTGGGTGAGCGCTGGC
TTCTCAAACGGCCGAAGTTGCCTCTTTTAGGAATCTCTTTGGAATTGGGAGCACGATGACTCTGAGTTTGAGCTATTAAAGTACTTCTTA

>62708_62708_2_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000346874_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1314AA_BP=992
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREF
LTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMI
QLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTVIIEDDRL
PVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLG
IADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGME
TWQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVD
EKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLD
GEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAG

--------------------------------------------------------------
>62708_62708_3_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000350537_HTRA1_chr10_124248418_ENST00000368984_length(transcript)=4550nt_BP=3030nt
GCGGCCCCGAGCGAGCGCCAGCGCCACACAGCCCCGGGCAGCCGCCGGCGAGCGCGCCGCGACGCCGAACAGGTGGCCGGAGGCTGCGGG
CGCCGCGGCGGGGAGAGGCGAGGCAAGCCCCGGGCGAAGCGAGGCGAGGCGAGGGCGGCCGGGCCGGGCATGCGAGCTGAGCGGCCCCCC
GGCGTCGCCGCCGCCTGCCCGCGCCCCTAGCCGCCCGCGCGCCCGAGTCCCCAGCGGCTCCTCCGCGCCCAGCGTCCTCGGTCCCGGCCT
CGGCTGCTCCGGCTGCGCTCGGCGAGGGGCGCGGGCCCGCCCGCGGCGGCGGCGGCATGAAAGTGACCGTGTGCTTCGGACGGACCCGGG
TGGTCGTGCCGTGCGGGGACGGCCACATGAAAGTTTTCAGCCTCATCCAGCAGGCGGTGACCCGCTACCGGAAGGCCATCGCCAAGGATC
CAAACTACTGGATACAGGTGCATCGCTTGGAACATGGAGATGGAGGAATACTAGACCTTGATGACATTCTTTGTGATGTAGCAGACGATA
AAGACAGACTGGTAGCAGTGTTTGATGAGCAGGATCCACATCACGGAGGTGATGGCACCAGTGCCAGTTCCACGGGTACCCAGAGCCCAG
AGATATTTGGTAGTGAGCTTGGCACCAACAATGTCTCAGCCTTTCAGCCTTACCAAGCAACAAGTGAAATTGAGGTCACACCTTCAGTCC
TTCGAGCAAATATGCCTCTTCATGTTCGACGCAGTAGTGACCCAGCTCTAATTGGCCTCTCCACTTCTGTCAGTGATAGTAATTTTTCCT
CTGAAGAGCCTTCAAGGAAAAATCCCACACGCTGGTCAACAACAGCTGGCTTCCTCAAGCAGAACACTGCTGGGAGTCCTAAAACCTGCG
ACAGGAAGAAAGATGAAAACTACAGAAGCCTCCCGCGGGATACTAGTAACTGGTCTAACCAATTTCAGAGAGACAATGCTCGCTCGTCTC
TGAGTGCCAGTCACCCAATGGTGGGCAAGTGGCTGGAGAAACAAGAACAGGATGAGGATGGGACAGAAGAGGATAACAGTCGTGTTGAAC
CTGTTGGACATGCTGACACGGGTTTGGAGCATATACCCAACTTTTCTCTGGATGATATGGTAAAGCTCGTAGAAGTCCCCAACGATGGAG
GGCCTCTGGGAATCCACGTAGTGCCTTTCAGTGCTCGAGGCGGCAGAACCCTGGGGTTATTAGTAAAACGATTGGAGAAAGGTGGTAAAG
CTGAACATGAAAATCTTTTTCGTGAGAATGATTGCATTGTCAGGATTAATGATGGCGACCTTCGAAATAGAAGATTTGAACAAGCACAAC
ATATGTTTCGCCAAGCCATGCGTACACCCATCATTTGGTTCCATGTGGTTCCTGCAGCAAATAAAGAGCAGTATGAACAACTATCCCAAA
GTGAGAAGAACAATTACTATTCAAGCCGTTTTAGCCCTGACAGCCAGTATATTGACAACAGGAGTGTGAACAGTGCAGGGCTTCACACGG
TGCAGAGAGCACCCCGACTGAACCACCCGCCTGAGCAGATAGACTCTCACTCAAGACTACCTCATAGCGCACACCCCTCGGGAAAACCAC
CATCCGCTCCAGCCTCGGCACCTCAGAATGTATTTAGTACGACTGTAAGCAGTGGTTATAACACCAAAAAAATAGGCAAGAGGCTTAATA
TCCAGCTTAAGAAAGGTACAGAAGGTTTGGGATTCAGCATCACTTCCAGAGATGTAACAATAGGTGGCTCAGCTCCAATCTATGTGAAAA
ACATTCTCCCCCGGGGGGCGGCCATTCAGGATGGCCGACTTAAGGCAGGAGACAGACTTATAGAGGTAAATGGAGTAGATTTAGTGGGCA
AATCCCAAGAGGAAGTTGTTTCGCTGTTGAGAAGCACCAAGATGGAAGGAACTGTGAGCCTTCTGGTCTTTCGCCAGGAAGACGCCTTCC
ACCCAAGGGAACTGAAAGCAGAAGATGAGGATATTGTTCTTACACCTGATGGCACCAGGGAATTTCTGACATTTGAAGTCCCACTTAATG
ATTCAGGATCTGCAGGCCTTGGTGTCAGTGTCAAAGGTAACCGGTCAAAAGAGAACCACGCAGATTTGGGAATCTTTGTCAAGTCCATTA
TTAATGGAGGAGCAGCATCTAAAGATGGAAGGCTTCGGGTGAATGATCAACTGATAGCAGTAAATGGAGAATCCCTGTTGGGCAAGACAA
ACCAAGATGCCATGGAAACCCTAAGAAGGTCTATGTCTACTGAAGGCAATAAACGAGGAATGATCCAGCTTATTGTTGCAAGGAGAATAA
GCAAGTGCAATGAGCTGAAGTCACCTGGGAGCCCCCCTGGACCTGAGCTGCCCATTGAAACAGCGTTGGATGATAGAGAACGAAGAATTT
CCCATTCCCTCTACAGTGGGATTGAGGGGCTTGATGAATCGCCCAGCAGAAATGCTGCCCTCAGTAGGATAATGGGTAAATACCAGCTGT
CCCCTACAGTGAATATGCCCCAAGATGACACTGTCATTATAGAAGATGACAGGTTGCCAGTGCTTCCTCCACATCTCTCTGACCAGTCCT
CTTCCAGCTCCCATGATGATGTGGGGTTTGTGACGGCAGATGCTGGTACTTGGGCCAAGGCTGCAATCAGTGATTCAGCCGACTGCTCTT
TGAGTCCAGATGTTGATCCAGTTCTTGCTTTTCAACGAGAAGGATTTGGACGTCAGATAGCTGACGAGACTAAACTCAATACAGTGGATG
ACCAGAAAGCAGGTTCTCCCAGCAGAGATGTGGGTCCTTCCCTGGGTCTGAAGAAGTCAAGCTCGTTGGAGAGTCTGCAGACCGCAGTTG
CCGAGGTGACTTTGAATGGGGATATTCCTTTCCATCGTCCACGGCCGCGGATAATCAGAGGCAGGGGATGCAATGAGAGCTTCAGAGCTG
CCATCGACAAATCTTATGATAAACCCGCGGTAGATGATGATGATGAAGGCATGGAGACCTGGCAGGAAGATCCCAACAGTTTGCGCCATA
AATATAACTTTATCGCGGACGTGGTGGAGAAGATCGCCCCTGCCGTGGTTCATATCGAATTGTTTCGCAAGCTTCCGTTTTCTAAACGAG
AGGTGCCGGTGGCTAGTGGGTCTGGGTTTATTGTGTCGGAAGATGGACTGATCGTGACAAATGCCCACGTGGTGACCAACAAGCACCGGG
TCAAAGTTGAGCTGAAGAACGGTGCCACTTACGAAGCCAAAATCAAGGATGTGGATGAGAAAGCAGACATCGCACTCATCAAAATTGACC
ACCAGGGCAAGCTGCCTGTCCTGCTGCTTGGCCGCTCCTCAGAGCTGCGGCCGGGAGAGTTCGTGGTCGCCATCGGAAGCCCGTTTTCCC
TTCAAAACACAGTCACCACCGGGATCGTGAGCACCACCCAGCGAGGCGGCAAAGAGCTGGGGCTCCGCAACTCAGACATGGACTACATCC
AGACCGACGCCATCATCAACTATGGAAACTCGGGAGGCCCGTTAGTAAACCTGGACGGTGAAGTGATTGGAATTAACACTTTGAAAGTGA
CAGCTGGAATCTCCTTTGCAATCCCATCTGATAAGATTAAAAAGTTCCTCACGGAGTCCCATGACCGACAGGCCAAAGGAAAAGCCATCA
CCAAGAAGAAGTATATTGGTATCCGAATGATGTCACTCACGTCCAGCAAAGCCAAAGAGCTGAAGGACCGGCACCGGGACTTCCCAGACG
TGATCTCAGGAGCGTATATAATTGAAGTAATTCCTGATACCCCAGCAGAAGCTGGTGGTCTCAAGGAAAACGACGTCATAATCAGCATCA
ATGGACAGTCCGTGGTCTCCGCCAATGATGTCAGCGACGTCATTAAAAGGGAAAGCACCCTGAACATGGTGGTCCGCAGGGGTAATGAAG
ATATCATGATCACAGTGATTCCCGAAGAAATTGACCCATAGGCAGAGGCATGAGCTGGACTTCATGTTTCCCTCAAAGACTCTCCCGTGG
ATGACGGATGAGGACTCTGGGCTGCTGGAATAGGACACTCAAGACTTTTGACTGCCATTTTGTTTGTTCAGTGGAGACTCCCTGGCCAAC
AGAATCCTTCTTGATAGTTTGCAGGCAAAACAAATGTAATGTTGCAGATCCGCAGGCAGAAGCTCTGCCCTTCTGTATCCTATGTATGCA
GTGTGCTTTTTCTTGCCAGCTTGGGCCATTCTTGCTTAGACAGTCAGCATTTGTCTCCTCCTTTAACTGAGTCATCATCTTAGTCCAACT
AATGCAGTCGATACAATGCGTAGATAGAAGAAGCCCCACGGGAGCCAGGATGGGACTGGTCGTGTTTGTGCTTTTCTCCAAGTCAGCACC
CAAAGGTCAATGCACAGAGACCCCGGGTGGGTGAGCGCTGGCTTCTCAAACGGCCGAAGTTGCCTCTTTTAGGAATCTCTTTGGAATTGG

>62708_62708_3_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000350537_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1268AA_BP=946
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELKAEDEDIVLTPDGTREFLTFEVPLNDSGSA
GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNE
LKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSH
DDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTL
NGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETWQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVA
SGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTV
TTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKY
IGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMIT

--------------------------------------------------------------
>62708_62708_4_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374773_HTRA1_chr10_124248418_ENST00000368984_length(transcript)=4589nt_BP=3069nt
GCGGCCCCGAGCGAGCGCCAGCGCCACACAGCCCCGGGCAGCCGCCGGCGAGCGCGCCGCGACGCCGAACAGGTGGCCGGAGGCTGCGGG
CGCCGCGGCGGGGAGAGGCGAGGCAAGCCCCGGGCGAAGCGAGGCGAGGCGAGGGCGGCCGGGCCGGGCATGCGAGCTGAGCGGCCCCCC
GGCGTCGCCGCCGCCTGCCCGCGCCCCTAGCCGCCCGCGCGCCCGAGTCCCCAGCGGCTCCTCCGCGCCCAGCGTCCTCGGTCCCGGCCT
CGGCTGCTCCGGCTGCGCTCGGCGAGGGGCGCGGGCCCGCCCGCGGCGGCGGCGGCATGAAAGTGACCGTGTGCTTCGGACGGACCCGGG
TGGTCGTGCCGTGCGGGGACGGCCACATGAAAGTTTTCAGCCTCATCCAGCAGGCGGTGACCCGCTACCGGAAGGCCATCGCCAAGGATC
CAAACTACTGGATACAGGTGCATCGCTTGGAACATGGAGATGGAGGAATACTAGACCTTGATGACATTCTTTGTGATGTAGCAGACGATA
AAGACAGACTGGTAGCAGTGTTTGATGAGCAGGATCCACATCACGGAGGTGATGGCACCAGTGCCAGTTCCACGGGTACCCAGAGCCCAG
AGATATTTGGTAGTGAGCTTGGCACCAACAATGTCTCAGCCTTTCAGCCTTACCAAGCAACAAGTGAAATTGAGGTCACACCTTCAGTCC
TTCGAGCAAATATGCCTCTTCATGTTCGACGCAGTAGTGACCCAGCTCTAATTGGCCTCTCCACTTCTGTCAGTGATAGTAATTTTTCCT
CTGAAGAGCCTTCAAGGAAAAATCCCACACGCTGGTCAACAACAGCTGGCTTCCTCAAGCAGAACACTGCTGGGAGTCCTAAAACCTGCG
ACAGGAAGAAAGATGAAAACTACAGAAGCCTCCCGCGGGATACTAGTAACTGGTCTAACCAATTTCAGAGAGACAATGCTCGCTCGTCTC
TGAGTGCCAGTCACCCAATGGTGGGCAAGTGGCTGGAGAAACAAGAACAGGATGAGGATGGGACAGAAGAGGATAACAGTCGTGTTGAAC
CTGTTGGACATGCTGACACGGGTTTGGAGCATATACCCAACTTTTCTCTGGATGATATGGTAAAGCTCGTAGAAGTCCCCAACGATGGAG
GGCCTCTGGGAATCCACGTAGTGCCTTTCAGTGCTCGAGGCGGCAGAACCCTGGGGTTATTAGTAAAACGATTGGAGAAAGGTGGTAAAG
CTGAACATGAAAATCTTTTTCGTGAGAATGATTGCATTGTCAGGATTAATGATGGCGACCTTCGAAATAGAAGATTTGAACAAGCACAAC
ATATGTTTCGCCAAGCCATGCGTACACCCATCATTTGGTTCCATGTGGTTCCTGCAGCAAATAAAGAGCAGTATGAACAACTATCCCAAA
GTGAGAAGAACAATTACTATTCAAGCCGTTTTAGCCCTGACAGCCAGTATATTGACAACAGGAGTGTGAACAGTGCAGGGCTTCACACGG
TGCAGAGAGCACCCCGACTGAACCACCCGCCTGAGCAGATAGACTCTCACTCAAGACTACCTCATAGCGCACACCCCTCGGGAAAACCAC
CATCCGCTCCAGCCTCGGCACCTCAGAATGTATTTAGTACGACTGTAAGCAGTGGTTATAACACCAAAAAAATAGGCAAGAGGCTTAATA
TCCAGCTTAAGAAAGGTACAGAAGGTTTGGGATTCAGCATCACTTCCAGAGATGTAACAATAGGTGGCTCAGCTCCAATCTATGTGAAAA
ACATTCTCCCCCGGGGGGCGGCCATTCAGGATGGCCGACTTAAGGCAGGAGACAGACTTATAGAGGTAAATGGAGTAGATTTAGTGGGCA
AATCCCAAGAGGAAGTTGTTTCGCTGTTGAGAAGCACCAAGATGGAAGGAACTGTGAGCCTTCTGGTCTTTCGCCAGGAAGACGCCTTCC
ACCCAAGGGAACTGAATGCAGAGCCAAGCCAGATGCAGATTCCAAAAGAAACGAAAGCAGAAGATGAGGATATTGTTCTTACACCTGATG
GCACCAGGGAATTTCTGACATTTGAAGTCCCACTTAATGATTCAGGATCTGCAGGCCTTGGTGTCAGTGTCAAAGGTAACCGGTCAAAAG
AGAACCACGCAGATTTGGGAATCTTTGTCAAGTCCATTATTAATGGAGGAGCAGCATCTAAAGATGGAAGGCTTCGGGTGAATGATCAAC
TGATAGCAGTAAATGGAGAATCCCTGTTGGGCAAGACAAACCAAGATGCCATGGAAACCCTAAGAAGGTCTATGTCTACTGAAGGCAATA
AACGAGGAATGATCCAGCTTATTGTTGCAAGGAGAATAAGCAAGTGCAATGAGCTGAAGTCACCTGGGAGCCCCCCTGGACCTGAGCTGC
CCATTGAAACAGCGTTGGATGATAGAGAACGAAGAATTTCCCATTCCCTCTACAGTGGGATTGAGGGGCTTGATGAATCGCCCAGCAGAA
ATGCTGCCCTCAGTAGGATAATGGGTAAATACCAGCTGTCCCCTACAGTGAATATGCCCCAAGATGACACTGTCATTATAGAAGATGACA
GGTTGCCAGTGCTTCCTCCACATCTCTCTGACCAGTCCTCTTCCAGCTCCCATGATGATGTGGGGTTTGTGACGGCAGATGCTGGTACTT
GGGCCAAGGCTGCAATCAGTGATTCAGCCGACTGCTCTTTGAGTCCAGATGTTGATCCAGTTCTTGCTTTTCAACGAGAAGGATTTGGAC
GTCAGATAGCTGACGAGACTAAACTCAATACAGTGGATGACCAGAAAGCAGGTTCTCCCAGCAGAGATGTGGGTCCTTCCCTGGGTCTGA
AGAAGTCAAGCTCGTTGGAGAGTCTGCAGACCGCAGTTGCCGAGGTGACTTTGAATGGGGATATTCCTTTCCATCGTCCACGGCCGCGGA
TAATCAGAGGCAGGGGATGCAATGAGAGCTTCAGAGCTGCCATCGACAAATCTTATGATAAACCCGCGGTAGATGATGATGATGAAGGCA
TGGAGACCTGGCAGGAAGATCCCAACAGTTTGCGCCATAAATATAACTTTATCGCGGACGTGGTGGAGAAGATCGCCCCTGCCGTGGTTC
ATATCGAATTGTTTCGCAAGCTTCCGTTTTCTAAACGAGAGGTGCCGGTGGCTAGTGGGTCTGGGTTTATTGTGTCGGAAGATGGACTGA
TCGTGACAAATGCCCACGTGGTGACCAACAAGCACCGGGTCAAAGTTGAGCTGAAGAACGGTGCCACTTACGAAGCCAAAATCAAGGATG
TGGATGAGAAAGCAGACATCGCACTCATCAAAATTGACCACCAGGGCAAGCTGCCTGTCCTGCTGCTTGGCCGCTCCTCAGAGCTGCGGC
CGGGAGAGTTCGTGGTCGCCATCGGAAGCCCGTTTTCCCTTCAAAACACAGTCACCACCGGGATCGTGAGCACCACCCAGCGAGGCGGCA
AAGAGCTGGGGCTCCGCAACTCAGACATGGACTACATCCAGACCGACGCCATCATCAACTATGGAAACTCGGGAGGCCCGTTAGTAAACC
TGGACGGTGAAGTGATTGGAATTAACACTTTGAAAGTGACAGCTGGAATCTCCTTTGCAATCCCATCTGATAAGATTAAAAAGTTCCTCA
CGGAGTCCCATGACCGACAGGCCAAAGGAAAAGCCATCACCAAGAAGAAGTATATTGGTATCCGAATGATGTCACTCACGTCCAGCAAAG
CCAAAGAGCTGAAGGACCGGCACCGGGACTTCCCAGACGTGATCTCAGGAGCGTATATAATTGAAGTAATTCCTGATACCCCAGCAGAAG
CTGGTGGTCTCAAGGAAAACGACGTCATAATCAGCATCAATGGACAGTCCGTGGTCTCCGCCAATGATGTCAGCGACGTCATTAAAAGGG
AAAGCACCCTGAACATGGTGGTCCGCAGGGGTAATGAAGATATCATGATCACAGTGATTCCCGAAGAAATTGACCCATAGGCAGAGGCAT
GAGCTGGACTTCATGTTTCCCTCAAAGACTCTCCCGTGGATGACGGATGAGGACTCTGGGCTGCTGGAATAGGACACTCAAGACTTTTGA
CTGCCATTTTGTTTGTTCAGTGGAGACTCCCTGGCCAACAGAATCCTTCTTGATAGTTTGCAGGCAAAACAAATGTAATGTTGCAGATCC
GCAGGCAGAAGCTCTGCCCTTCTGTATCCTATGTATGCAGTGTGCTTTTTCTTGCCAGCTTGGGCCATTCTTGCTTAGACAGTCAGCATT
TGTCTCCTCCTTTAACTGAGTCATCATCTTAGTCCAACTAATGCAGTCGATACAATGCGTAGATAGAAGAAGCCCCACGGGAGCCAGGAT
GGGACTGGTCGTGTTTGTGCTTTTCTCCAAGTCAGCACCCAAAGGTCAATGCACAGAGACCCCGGGTGGGTGAGCGCTGGCTTCTCAAAC

>62708_62708_4_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374773_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1281AA_BP=959
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREF
LTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMI
QLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVL
PPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSS
LESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETWQEDPNSLRHKYNFIADVVEKIAPAVVHIELF
RKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFV
VAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHD
RQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLN

--------------------------------------------------------------
>62708_62708_5_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374776_HTRA1_chr10_124248418_ENST00000368984_length(transcript)=4550nt_BP=3030nt
GCGGCCCCGAGCGAGCGCCAGCGCCACACAGCCCCGGGCAGCCGCCGGCGAGCGCGCCGCGACGCCGAACAGGTGGCCGGAGGCTGCGGG
CGCCGCGGCGGGGAGAGGCGAGGCAAGCCCCGGGCGAAGCGAGGCGAGGCGAGGGCGGCCGGGCCGGGCATGCGAGCTGAGCGGCCCCCC
GGCGTCGCCGCCGCCTGCCCGCGCCCCTAGCCGCCCGCGCGCCCGAGTCCCCAGCGGCTCCTCCGCGCCCAGCGTCCTCGGTCCCGGCCT
CGGCTGCTCCGGCTGCGCTCGGCGAGGGGCGCGGGCCCGCCCGCGGCGGCGGCGGCATGAAAGTGACCGTGTGCTTCGGACGGACCCGGG
TGGTCGTGCCGTGCGGGGACGGCCACATGAAAGTTTTCAGCCTCATCCAGCAGGCGGTGACCCGCTACCGGAAGGCCATCGCCAAGGATC
CAAACTACTGGATACAGGTGCATCGCTTGGAACATGGAGATGGAGGAATACTAGACCTTGATGACATTCTTTGTGATGTAGCAGACGATA
AAGACAGACTGGTAGCAGTGTTTGATGAGCAGGATCCACATCACGGAGGTGATGGCACCAGTGCCAGTTCCACGGGTACCCAGAGCCCAG
AGATATTTGGTAGTGAGCTTGGCACCAACAATGTCTCAGCCTTTCAGCCTTACCAAGCAACAAGTGAAATTGAGGTCACACCTTCAGTCC
TTCGAGCAAATATGCCTCTTCATGTTCGACGCAGTAGTGACCCAGCTCTAATTGGCCTCTCCACTTCTGTCAGTGATAGTAATTTTTCCT
CTGAAGAGCCTTCAAGGAAAAATCCCACACGCTGGTCAACAACAGCTGGCTTCCTCAAGCAGAACACTGCTGGGAGTCCTAAAACCTGCG
ACAGGAAGAAAGATGAAAACTACAGAAGCCTCCCGCGGGATACTAGTAACTGGTCTAACCAATTTCAGAGAGACAATGCTCGCTCGTCTC
TGAGTGCCAGTCACCCAATGGTGGGCAAGTGGCTGGAGAAACAAGAACAGGATGAGGATGGGACAGAAGAGGATAACAGTCGTGTTGAAC
CTGTTGGACATGCTGACACGGGTTTGGAGCATATACCCAACTTTTCTCTGGATGATATGGTAAAGCTCGTAGAAGTCCCCAACGATGGAG
GGCCTCTGGGAATCCACGTAGTGCCTTTCAGTGCTCGAGGCGGCAGAACCCTGGGGTTATTAGTAAAACGATTGGAGAAAGGTGGTAAAG
CTGAACATGAAAATCTTTTTCGTGAGAATGATTGCATTGTCAGGATTAATGATGGCGACCTTCGAAATAGAAGATTTGAACAAGCACAAC
ATATGTTTCGCCAAGCCATGCGTACACCCATCATTTGGTTCCATGTGGTTCCTGCAGCAAATAAAGAGCAGTATGAACAACTATCCCAAA
GTGAGAAGAACAATTACTATTCAAGCCGTTTTAGCCCTGACAGCCAGTATATTGACAACAGGAGTGTGAACAGTGCAGGGCTTCACACGG
TGCAGAGAGCACCCCGACTGAACCACCCGCCTGAGCAGATAGACTCTCACTCAAGACTACCTCATAGCGCACACCCCTCGGGAAAACCAC
CATCCGCTCCAGCCTCGGCACCTCAGAATGTATTTAGTACGACTGTAAGCAGTGGTTATAACACCAAAAAAATAGGCAAGAGGCTTAATA
TCCAGCTTAAGAAAGGTACAGAAGGTTTGGGATTCAGCATCACTTCCAGAGATGTAACAATAGGTGGCTCAGCTCCAATCTATGTGAAAA
ACATTCTCCCCCGGGGGGCGGCCATTCAGGATGGCCGACTTAAGGCAGGAGACAGACTTATAGAGGTAAATGGAGTAGATTTAGTGGGCA
AATCCCAAGAGGAAGTTGTTTCGCTGTTGAGAAGCACCAAGATGGAAGGAACTGTGAGCCTTCTGGTCTTTCGCCAGGAAGACGCCTTCC
ACCCAAGGGAACTGAAAGCAGAAGATGAGGATATTGTTCTTACACCTGATGGCACCAGGGAATTTCTGACATTTGAAGTCCCACTTAATG
ATTCAGGATCTGCAGGCCTTGGTGTCAGTGTCAAAGGTAACCGGTCAAAAGAGAACCACGCAGATTTGGGAATCTTTGTCAAGTCCATTA
TTAATGGAGGAGCAGCATCTAAAGATGGAAGGCTTCGGGTGAATGATCAACTGATAGCAGTAAATGGAGAATCCCTGTTGGGCAAGACAA
ACCAAGATGCCATGGAAACCCTAAGAAGGTCTATGTCTACTGAAGGCAATAAACGAGGAATGATCCAGCTTATTGTTGCAAGGAGAATAA
GCAAGTGCAATGAGCTGAAGTCACCTGGGAGCCCCCCTGGACCTGAGCTGCCCATTGAAACAGCGTTGGATGATAGAGAACGAAGAATTT
CCCATTCCCTCTACAGTGGGATTGAGGGGCTTGATGAATCGCCCAGCAGAAATGCTGCCCTCAGTAGGATAATGGGTAAATACCAGCTGT
CCCCTACAGTGAATATGCCCCAAGATGACACTGTCATTATAGAAGATGACAGGTTGCCAGTGCTTCCTCCACATCTCTCTGACCAGTCCT
CTTCCAGCTCCCATGATGATGTGGGGTTTGTGACGGCAGATGCTGGTACTTGGGCCAAGGCTGCAATCAGTGATTCAGCCGACTGCTCTT
TGAGTCCAGATGTTGATCCAGTTCTTGCTTTTCAACGAGAAGGATTTGGACGTCAGATAGCTGACGAGACTAAACTCAATACAGTGGATG
ACCAGAAAGCAGGTTCTCCCAGCAGAGATGTGGGTCCTTCCCTGGGTCTGAAGAAGTCAAGCTCGTTGGAGAGTCTGCAGACCGCAGTTG
CCGAGGTGACTTTGAATGGGGATATTCCTTTCCATCGTCCACGGCCGCGGATAATCAGAGGCAGGGGATGCAATGAGAGCTTCAGAGCTG
CCATCGACAAATCTTATGATAAACCCGCGGTAGATGATGATGATGAAGGCATGGAGACCTGGCAGGAAGATCCCAACAGTTTGCGCCATA
AATATAACTTTATCGCGGACGTGGTGGAGAAGATCGCCCCTGCCGTGGTTCATATCGAATTGTTTCGCAAGCTTCCGTTTTCTAAACGAG
AGGTGCCGGTGGCTAGTGGGTCTGGGTTTATTGTGTCGGAAGATGGACTGATCGTGACAAATGCCCACGTGGTGACCAACAAGCACCGGG
TCAAAGTTGAGCTGAAGAACGGTGCCACTTACGAAGCCAAAATCAAGGATGTGGATGAGAAAGCAGACATCGCACTCATCAAAATTGACC
ACCAGGGCAAGCTGCCTGTCCTGCTGCTTGGCCGCTCCTCAGAGCTGCGGCCGGGAGAGTTCGTGGTCGCCATCGGAAGCCCGTTTTCCC
TTCAAAACACAGTCACCACCGGGATCGTGAGCACCACCCAGCGAGGCGGCAAAGAGCTGGGGCTCCGCAACTCAGACATGGACTACATCC
AGACCGACGCCATCATCAACTATGGAAACTCGGGAGGCCCGTTAGTAAACCTGGACGGTGAAGTGATTGGAATTAACACTTTGAAAGTGA
CAGCTGGAATCTCCTTTGCAATCCCATCTGATAAGATTAAAAAGTTCCTCACGGAGTCCCATGACCGACAGGCCAAAGGAAAAGCCATCA
CCAAGAAGAAGTATATTGGTATCCGAATGATGTCACTCACGTCCAGCAAAGCCAAAGAGCTGAAGGACCGGCACCGGGACTTCCCAGACG
TGATCTCAGGAGCGTATATAATTGAAGTAATTCCTGATACCCCAGCAGAAGCTGGTGGTCTCAAGGAAAACGACGTCATAATCAGCATCA
ATGGACAGTCCGTGGTCTCCGCCAATGATGTCAGCGACGTCATTAAAAGGGAAAGCACCCTGAACATGGTGGTCCGCAGGGGTAATGAAG
ATATCATGATCACAGTGATTCCCGAAGAAATTGACCCATAGGCAGAGGCATGAGCTGGACTTCATGTTTCCCTCAAAGACTCTCCCGTGG
ATGACGGATGAGGACTCTGGGCTGCTGGAATAGGACACTCAAGACTTTTGACTGCCATTTTGTTTGTTCAGTGGAGACTCCCTGGCCAAC
AGAATCCTTCTTGATAGTTTGCAGGCAAAACAAATGTAATGTTGCAGATCCGCAGGCAGAAGCTCTGCCCTTCTGTATCCTATGTATGCA
GTGTGCTTTTTCTTGCCAGCTTGGGCCATTCTTGCTTAGACAGTCAGCATTTGTCTCCTCCTTTAACTGAGTCATCATCTTAGTCCAACT
AATGCAGTCGATACAATGCGTAGATAGAAGAAGCCCCACGGGAGCCAGGATGGGACTGGTCGTGTTTGTGCTTTTCTCCAAGTCAGCACC
CAAAGGTCAATGCACAGAGACCCCGGGTGGGTGAGCGCTGGCTTCTCAAACGGCCGAAGTTGCCTCTTTTAGGAATCTCTTTGGAATTGG

>62708_62708_5_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374776_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1268AA_BP=946
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELKAEDEDIVLTPDGTREFLTFEVPLNDSGSA
GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNE
LKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSH
DDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTL
NGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETWQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVA
SGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTV
TTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKY
IGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMIT

--------------------------------------------------------------
>62708_62708_6_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374788_HTRA1_chr10_124248418_ENST00000368984_length(transcript)=4679nt_BP=3159nt
GCGGCCCCGAGCGAGCGCCAGCGCCACACAGCCCCGGGCAGCCGCCGGCGAGCGCGCCGCGACGCCGAACAGGTGGCCGGAGGCTGCGGG
CGCCGCGGCGGGGAGAGGCGAGGCAAGCCCCGGGCGAAGCGAGGCGAGGCGAGGGCGGCCGGGCCGGGCATGCGAGCTGAGCGGCCCCCC
GGCGTCGCCGCCGCCTGCCCGCGCCCCTAGCCGCCCGCGCGCCCGAGTCCCCAGCGGCTCCTCCGCGCCCAGCGTCCTCGGTCCCGGCCT
CGGCTGCTCCGGCTGCGCTCGGCGAGGGGCGCGGGCCCGCCCGCGGCGGCGGCGGCATGAAAGTGACCGTGTGCTTCGGACGGACCCGGG
TGGTCGTGCCGTGCGGGGACGGCCACATGAAAGTTTTCAGCCTCATCCAGCAGGCGGTGACCCGCTACCGGAAGGCCATCGCCAAGGATC
CAAACTACTGGATACAGGTGCATCGCTTGGAACATGGAGATGGAGGAATACTAGACCTTGATGACATTCTTTGTGATGTAGCAGACGATA
AAGACAGACTGGTAGCAGTGTTTGATGAGCAGGATCCACATCACGGAGGTGATGGCACCAGTGCCAGTTCCACGGGTACCCAGAGCCCAG
AGATATTTGGTAGTGAGCTTGGCACCAACAATGTCTCAGCCTTTCAGCCTTACCAAGCAACAAGTGAAATTGAGGTCACACCTTCAGTCC
TTCGAGCAAATATGCCTCTTCATGTTCGACGCAGTAGTGACCCAGCTCTAATTGGCCTCTCCACTTCTGTCAGTGATAGTAATTTTTCCT
CTGAAGAGCCTTCAAGGAAAAATCCCACACGCTGGTCAACAACAGCTGGCTTCCTCAAGCAGAACACTGCTGGGAGTCCTAAAACCTGCG
ACAGGAAGAAAGATGAAAACTACAGAAGCCTCCCGCGGGATACTAGTAACTGGTCTAACCAATTTCAGAGAGACAATGCTCGCTCGTCTC
TGAGTGCCAGTCACCCAATGGTGGGCAAGTGGCTGGAGAAACAAGAACAGGATGAGGATGGGACAGAAGAGGATAACAGTCGTGTTGAAC
CTGTTGGACATGCTGACACGGGTTTGGAGCATATACCCAACTTTTCTCTGGATGATATGGTAAAGCTCGTAGAAGTCCCCAACGATGGAG
GGCCTCTGGGAATCCACGTAGTGCCTTTCAGTGCTCGAGGCGGCAGAACCCTGGGGTTATTAGTAAAACGATTGGAGAAAGGTGGTAAAG
CTGAACATGAAAATCTTTTTCGTGAGAATGATTGCATTGTCAGGATTAATGATGGCGACCTTCGAAATAGAAGATTTGAACAAGCACAAC
ATATGTTTCGCCAAGCCATGCGTACACCCATCATTTGGTTCCATGTGGTTCCTGCAGCAAATAAAGAGCAGTATGAACAACTATCCCAAA
GTGAGAAGAACAATTACTATTCAAGCCGTTTTAGCCCTGACAGCCAGTATATTGACAACAGGAGTGTGAACAGTGCAGGGCTTCACACGG
TGCAGAGAGCACCCCGACTGAACCACCCGCCTGAGCAGATAGACTCTCACTCAAGACTACCTCATAGCGCACACCCCTCGGGAAAACCAC
CATCCGCTCCAGCCTCGGCACCTCAGAATGTATTTAGTACGACTGTAAGCAGTGGTTATAACACCAAAAAAATAGGCAAGAGGCTTAATA
TCCAGCTTAAGAAAGGTACAGAAGGTTTGGGATTCAGCATCACTTCCAGAGATGTAACAATAGGTGGCTCAGCTCCAATCTATGTGAAAA
ACATTCTCCCCCGGGGGGCGGCCATTCAGGATGGCCGACTTAAGGCAGGAGACAGACTTATAGAGGTAAATGGAGTAGATTTAGTGGGCA
AATCCCAAGAGGAAGTTGTTTCGCTGTTGAGAAGCACCAAGATGGAAGGAACTGTGAGCCTTCTGGTCTTTCGCCAGGAAGACGCCTTCC
ACCCAAGGGAACTGAATGCAGAGCCAAGCCAGATGCAGATTCCAAAAGAAACGAAAGCAGAAGATGAGGATATTGTTCTTACACCTGATG
GCACCAGGGAATTTCTGACATTTGAAGTCCCACTTAATGATTCAGGATCTGCAGGCCTTGGTGTCAGTGTCAAAGGTAACCGGTCAAAAG
AGAACCACGCAGATTTGGGAATCTTTGTCAAGTCCATTATTAATGGAGGAGCAGCATCTAAAGATGGAAGGCTTCGGGTGAATGATCAAC
TGATAGCAGTAAATGGAGAATCCCTGTTGGGCAAGACAAACCAAGATGCCATGGAAACCCTAAGAAGGTCTATGTCTACTGAAGGCAATA
AACGAGGAATGATCCAGCTTATTGTTGCAAGGAGAATAAGCAAGTGCAATGAGCTGAAGTCACCTGGGAGCCCCCCTGGACCTGAGCTGC
CCATTGAAACAGCGTTGGATGATAGAGAACGAAGAATTTCCCATTCCCTCTACAGTGGGATTGAGGGGCTTGATGAATCGCCCAGCAGAA
ATGCTGCCCTCAGTAGGATAATGGGTAAATACCAGCTGTCCCCTACAGTGAATATGCCCCAAGATGACACTGTCATTATAGAAGATGACA
GGTTGCCAGTGCTTCCTCCACATCTCTCTGACCAGTCCTCTTCCAGCTCCCATGATGATGTGGGGTTTGTGACGGCAGATGCTGGTACTT
GGGCCAAGGCTGCAATCAGTGATTCAGCCGACTGCTCTTTGAGTCCAGATGTTGATCCAGTTCTTGCTTTTCAACGAGAAGGATTTGGAC
GTCAGAGTATGTCAGAAAAACGCACAAAGCAATTTTCAGATGCCAGTCAATTGGATTTCGTTAAAACACGAAAATCAAAAAGCATGGATT
TAGGTATAGCTGACGAGACTAAACTCAATACAGTGGATGACCAGAAAGCAGGTTCTCCCAGCAGAGATGTGGGTCCTTCCCTGGGTCTGA
AGAAGTCAAGCTCGTTGGAGAGTCTGCAGACCGCAGTTGCCGAGGTGACTTTGAATGGGGATATTCCTTTCCATCGTCCACGGCCGCGGA
TAATCAGAGGCAGGGGATGCAATGAGAGCTTCAGAGCTGCCATCGACAAATCTTATGATAAACCCGCGGTAGATGATGATGATGAAGGCA
TGGAGACCTGGCAGGAAGATCCCAACAGTTTGCGCCATAAATATAACTTTATCGCGGACGTGGTGGAGAAGATCGCCCCTGCCGTGGTTC
ATATCGAATTGTTTCGCAAGCTTCCGTTTTCTAAACGAGAGGTGCCGGTGGCTAGTGGGTCTGGGTTTATTGTGTCGGAAGATGGACTGA
TCGTGACAAATGCCCACGTGGTGACCAACAAGCACCGGGTCAAAGTTGAGCTGAAGAACGGTGCCACTTACGAAGCCAAAATCAAGGATG
TGGATGAGAAAGCAGACATCGCACTCATCAAAATTGACCACCAGGGCAAGCTGCCTGTCCTGCTGCTTGGCCGCTCCTCAGAGCTGCGGC
CGGGAGAGTTCGTGGTCGCCATCGGAAGCCCGTTTTCCCTTCAAAACACAGTCACCACCGGGATCGTGAGCACCACCCAGCGAGGCGGCA
AAGAGCTGGGGCTCCGCAACTCAGACATGGACTACATCCAGACCGACGCCATCATCAACTATGGAAACTCGGGAGGCCCGTTAGTAAACC
TGGACGGTGAAGTGATTGGAATTAACACTTTGAAAGTGACAGCTGGAATCTCCTTTGCAATCCCATCTGATAAGATTAAAAAGTTCCTCA
CGGAGTCCCATGACCGACAGGCCAAAGGAAAAGCCATCACCAAGAAGAAGTATATTGGTATCCGAATGATGTCACTCACGTCCAGCAAAG
CCAAAGAGCTGAAGGACCGGCACCGGGACTTCCCAGACGTGATCTCAGGAGCGTATATAATTGAAGTAATTCCTGATACCCCAGCAGAAG
CTGGTGGTCTCAAGGAAAACGACGTCATAATCAGCATCAATGGACAGTCCGTGGTCTCCGCCAATGATGTCAGCGACGTCATTAAAAGGG
AAAGCACCCTGAACATGGTGGTCCGCAGGGGTAATGAAGATATCATGATCACAGTGATTCCCGAAGAAATTGACCCATAGGCAGAGGCAT
GAGCTGGACTTCATGTTTCCCTCAAAGACTCTCCCGTGGATGACGGATGAGGACTCTGGGCTGCTGGAATAGGACACTCAAGACTTTTGA
CTGCCATTTTGTTTGTTCAGTGGAGACTCCCTGGCCAACAGAATCCTTCTTGATAGTTTGCAGGCAAAACAAATGTAATGTTGCAGATCC
GCAGGCAGAAGCTCTGCCCTTCTGTATCCTATGTATGCAGTGTGCTTTTTCTTGCCAGCTTGGGCCATTCTTGCTTAGACAGTCAGCATT
TGTCTCCTCCTTTAACTGAGTCATCATCTTAGTCCAACTAATGCAGTCGATACAATGCGTAGATAGAAGAAGCCCCACGGGAGCCAGGAT
GGGACTGGTCGTGTTTGTGCTTTTCTCCAAGTCAGCACCCAAAGGTCAATGCACAGAGACCCCGGGTGGGTGAGCGCTGGCTTCTCAAAC

>62708_62708_6_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374788_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1311AA_BP=989
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREF
LTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMI
QLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVL
PPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIAD
ETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETWQ
EDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKA
DIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEV
IGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLK

--------------------------------------------------------------
>62708_62708_7_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374789_HTRA1_chr10_124248418_ENST00000368984_length(transcript)=4688nt_BP=3168nt
GCGGCCCCGAGCGAGCGCCAGCGCCACACAGCCCCGGGCAGCCGCCGGCGAGCGCGCCGCGACGCCGAACAGGTGGCCGGAGGCTGCGGG
CGCCGCGGCGGGGAGAGGCGAGGCAAGCCCCGGGCGAAGCGAGGCGAGGCGAGGGCGGCCGGGCCGGGCATGCGAGCTGAGCGGCCCCCC
GGCGTCGCCGCCGCCTGCCCGCGCCCCTAGCCGCCCGCGCGCCCGAGTCCCCAGCGGCTCCTCCGCGCCCAGCGTCCTCGGTCCCGGCCT
CGGCTGCTCCGGCTGCGCTCGGCGAGGGGCGCGGGCCCGCCCGCGGCGGCGGCGGCATGAAAGTGACCGTGTGCTTCGGACGGACCCGGG
TGGTCGTGCCGTGCGGGGACGGCCACATGAAAGTTTTCAGCCTCATCCAGCAGGCGGTGACCCGCTACCGGAAGGCCATCGCCAAGGATC
CAAACTACTGGATACAGGTGCATCGCTTGGAACATGGAGATGGAGGAATACTAGACCTTGATGACATTCTTTGTGATGTAGCAGACGATA
AAGACAGACTGGTAGCAGTGTTTGATGAGCAGGATCCACATCACGGAGGTGATGGCACCAGTGCCAGTTCCACGGGTACCCAGAGCCCAG
AGATATTTGGTAGTGAGCTTGGCACCAACAATGTCTCAGCCTTTCAGCCTTACCAAGCAACAAGTGAAATTGAGGTCACACCTTCAGTCC
TTCGAGCAAATATGCCTCTTCATGTTCGACGCAGTAGTGACCCAGCTCTAATTGGCCTCTCCACTTCTGTCAGTGATAGTAATTTTTCCT
CTGAAGAGCCTTCAAGGAAAAATCCCACACGCTGGTCAACAACAGCTGGCTTCCTCAAGCAGAACACTGCTGGGAGTCCTAAAACCTGCG
ACAGGAAGAAAGATGAAAACTACAGAAGCCTCCCGCGGGATACTAGTAACTGGTCTAACCAATTTCAGAGAGACAATGCTCGCTCGTCTC
TGAGTGCCAGTCACCCAATGGTGGGCAAGTGGCTGGAGAAACAAGAACAGGATGAGGATGGGACAGAAGAGGATAACAGTCGTGTTGAAC
CTGTTGGACATGCTGACACGGGTTTGGAGCATATACCCAACTTTTCTCTGGATGATATGGTAAAGCTCGTAGAAGTCCCCAACGATGGAG
GGCCTCTGGGAATCCACGTAGTGCCTTTCAGTGCTCGAGGCGGCAGAACCCTGGGGTTATTAGTAAAACGATTGGAGAAAGGTGGTAAAG
CTGAACATGAAAATCTTTTTCGTGAGAATGATTGCATTGTCAGGATTAATGATGGCGACCTTCGAAATAGAAGATTTGAACAAGCACAAC
ATATGTTTCGCCAAGCCATGCGTACACCCATCATTTGGTTCCATGTGGTTCCTGCAGCAAATAAAGAGCAGTATGAACAACTATCCCAAA
GTGAGAAGAACAATTACTATTCAAGCCGTTTTAGCCCTGACAGCCAGTATATTGACAACAGGAGTGTGAACAGTGCAGGGCTTCACACGG
TGCAGAGAGCACCCCGACTGAACCACCCGCCTGAGCAGATAGACTCTCACTCAAGACTACCTCATAGCGCACACCCCTCGGGAAAACCAC
CATCCGCTCCAGCCTCGGCACCTCAGAATGTATTTAGTACGACTGTAAGCAGTGGTTATAACACCAAAAAAATAGGCAAGAGGCTTAATA
TCCAGCTTAAGAAAGGTACAGAAGGTTTGGGATTCAGCATCACTTCCAGAGATGTAACAATAGGTGGCTCAGCTCCAATCTATGTGAAAA
ACATTCTCCCCCGGGGGGCGGCCATTCAGGATGGCCGACTTAAGGCAGGAGACAGACTTATAGAGGTAAATGGAGTAGATTTAGTGGGCA
AATCCCAAGAGGAAGTTGTTTCGCTGTTGAGAAGCACCAAGATGGAAGGAACTGTGAGCCTTCTGGTCTTTCGCCAGGAAGACGCCTTCC
ACCCAAGGGAACTGAATGCAGAGCCAAGCCAGATGCAGATTCCAAAAGAAACGAAAGCAGAAGATGAGGATATTGTTCTTACACCTGATG
GCACCAGGGAATTTCTGACATTTGAAGTCCCACTTAATGATTCAGGATCTGCAGGCCTTGGTGTCAGTGTCAAAGGTAACCGGTCAAAAG
AGAACCACGCAGATTTGGGAATCTTTGTCAAGTCCATTATTAATGGAGGAGCAGCATCTAAAGATGGAAGGCTTCGGGTGAATGATCAAC
TGATAGCAGTAAATGGAGAATCCCTGTTGGGCAAGACAAACCAAGATGCCATGGAAACCCTAAGAAGGTCTATGTCTACTGAAGGCAATA
AACGAGGAATGATCCAGCTTATTGTTGCAAGGAGAATAAGCAAGTGCAATGAGCTGAAGTCACCTGGGAGCCCCCCTGGACCTGAGCTGC
CCATTGAAACAGCGTTGGATGATAGAGAACGAAGAATTTCCCATTCCCTCTACAGTGGGATTGAGGGGCTTGATGAATCGCCCAGCAGAA
ATGCTGCCCTCAGTAGGATAATGGGTGAGTCAGGTAAATACCAGCTGTCCCCTACAGTGAATATGCCCCAAGATGACACTGTCATTATAG
AAGATGACAGGTTGCCAGTGCTTCCTCCACATCTCTCTGACCAGTCCTCTTCCAGCTCCCATGATGATGTGGGGTTTGTGACGGCAGATG
CTGGTACTTGGGCCAAGGCTGCAATCAGTGATTCAGCCGACTGCTCTTTGAGTCCAGATGTTGATCCAGTTCTTGCTTTTCAACGAGAAG
GATTTGGACGTCAGAGTATGTCAGAAAAACGCACAAAGCAATTTTCAGATGCCAGTCAATTGGATTTCGTTAAAACACGAAAATCAAAAA
GCATGGATTTAGGTATAGCTGACGAGACTAAACTCAATACAGTGGATGACCAGAAAGCAGGTTCTCCCAGCAGAGATGTGGGTCCTTCCC
TGGGTCTGAAGAAGTCAAGCTCGTTGGAGAGTCTGCAGACCGCAGTTGCCGAGGTGACTTTGAATGGGGATATTCCTTTCCATCGTCCAC
GGCCGCGGATAATCAGAGGCAGGGGATGCAATGAGAGCTTCAGAGCTGCCATCGACAAATCTTATGATAAACCCGCGGTAGATGATGATG
ATGAAGGCATGGAGACCTGGCAGGAAGATCCCAACAGTTTGCGCCATAAATATAACTTTATCGCGGACGTGGTGGAGAAGATCGCCCCTG
CCGTGGTTCATATCGAATTGTTTCGCAAGCTTCCGTTTTCTAAACGAGAGGTGCCGGTGGCTAGTGGGTCTGGGTTTATTGTGTCGGAAG
ATGGACTGATCGTGACAAATGCCCACGTGGTGACCAACAAGCACCGGGTCAAAGTTGAGCTGAAGAACGGTGCCACTTACGAAGCCAAAA
TCAAGGATGTGGATGAGAAAGCAGACATCGCACTCATCAAAATTGACCACCAGGGCAAGCTGCCTGTCCTGCTGCTTGGCCGCTCCTCAG
AGCTGCGGCCGGGAGAGTTCGTGGTCGCCATCGGAAGCCCGTTTTCCCTTCAAAACACAGTCACCACCGGGATCGTGAGCACCACCCAGC
GAGGCGGCAAAGAGCTGGGGCTCCGCAACTCAGACATGGACTACATCCAGACCGACGCCATCATCAACTATGGAAACTCGGGAGGCCCGT
TAGTAAACCTGGACGGTGAAGTGATTGGAATTAACACTTTGAAAGTGACAGCTGGAATCTCCTTTGCAATCCCATCTGATAAGATTAAAA
AGTTCCTCACGGAGTCCCATGACCGACAGGCCAAAGGAAAAGCCATCACCAAGAAGAAGTATATTGGTATCCGAATGATGTCACTCACGT
CCAGCAAAGCCAAAGAGCTGAAGGACCGGCACCGGGACTTCCCAGACGTGATCTCAGGAGCGTATATAATTGAAGTAATTCCTGATACCC
CAGCAGAAGCTGGTGGTCTCAAGGAAAACGACGTCATAATCAGCATCAATGGACAGTCCGTGGTCTCCGCCAATGATGTCAGCGACGTCA
TTAAAAGGGAAAGCACCCTGAACATGGTGGTCCGCAGGGGTAATGAAGATATCATGATCACAGTGATTCCCGAAGAAATTGACCCATAGG
CAGAGGCATGAGCTGGACTTCATGTTTCCCTCAAAGACTCTCCCGTGGATGACGGATGAGGACTCTGGGCTGCTGGAATAGGACACTCAA
GACTTTTGACTGCCATTTTGTTTGTTCAGTGGAGACTCCCTGGCCAACAGAATCCTTCTTGATAGTTTGCAGGCAAAACAAATGTAATGT
TGCAGATCCGCAGGCAGAAGCTCTGCCCTTCTGTATCCTATGTATGCAGTGTGCTTTTTCTTGCCAGCTTGGGCCATTCTTGCTTAGACA
GTCAGCATTTGTCTCCTCCTTTAACTGAGTCATCATCTTAGTCCAACTAATGCAGTCGATACAATGCGTAGATAGAAGAAGCCCCACGGG
AGCCAGGATGGGACTGGTCGTGTTTGTGCTTTTCTCCAAGTCAGCACCCAAAGGTCAATGCACAGAGACCCCGGGTGGGTGAGCGCTGGC
TTCTCAAACGGCCGAAGTTGCCTCTTTTAGGAATCTCTTTGGAATTGGGAGCACGATGACTCTGAGTTTGAGCTATTAAAGTACTTCTTA

>62708_62708_7_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374789_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1314AA_BP=992
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREF
LTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMI
QLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTVIIEDDRL
PVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLG
IADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGME
TWQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVD
EKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLD
GEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAG

--------------------------------------------------------------
>62708_62708_8_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374790_HTRA1_chr10_124248418_ENST00000368984_length(transcript)=4508nt_BP=2988nt
GCGGCCCCGAGCGAGCGCCAGCGCCACACAGCCCCGGGCAGCCGCCGGCGAGCGCGCCGCGACGCCGAACAGGTGGCCGGAGGCTGCGGG
CGCCGCGGCGGGGAGAGGCGAGGCAAGCCCCGGGCGAAGCGAGGCGAGGCGAGGGCGGCCGGGCCGGGCATGCGAGCTGAGCGGCCCCCC
GGCGTCGCCGCCGCCTGCCCGCGCCCCTAGCCGCCCGCGCGCCCGAGTCCCCAGCGGCTCCTCCGCGCCCAGCGTCCTCGGTCCCGGCCT
CGGCTGCTCCGGCTGCGCTCGGCGAGGGGCGCGGGCCCGCCCGCGGCGGCGGCGGCATGAAAGTGACCGTGTGCTTCGGACGGACCCGGG
TGGTCGTGCCGTGCGGGGACGGCCACATGAAAGTTTTCAGCCTCATCCAGCAGGCGGTGACCCGCTACCGGAAGGCCATCGCCAAGGATC
CAAACTACTGGATACAGGTGCATCGCTTGGAACATGGAGATGGAGGAATACTAGACCTTGATGACATTCTTTGTGATGTAGCAGACGATA
AAGACAGACTGGTAGCAGTGTTTGATGAGCAGGATCCACATCACGGAGGTGATGGCACCAGTGCCAGTTCCACGGGTACCCAGAGCCCAG
AGATATTTGGTAGTGAGCTTGGCACCAACAATGTCTCAGCCTTTCAGCCTTACCAAGCAACAAGTGAAATTGAGGTCACACCTTCAGTCC
TTCGAGCAAATATGCCTCTTCATGTTCGACGCAGTAGTGACCCAGCTCTAATTGGCCTCTCCACTTCTGTCAGTGATAGTAATTTTTCCT
CTGAAGAGCCTTCAAGGAAAAATCCCACACGCTGGTCAACAACAGCTGGCTTCCTCAAGCAGAACACTGCTGGGAGTCCTAAAACCTGCG
ACAGGAAGGATGAGGATGGGACAGAAGAGGATAACAGTCGTGTTGAACCTGTTGGACATGCTGACACGGGTTTGGAGCATATACCCAACT
TTTCTCTGGATGATATGGTAAAGCTCGTAGAAGTCCCCAACGATGGAGGGCCTCTGGGAATCCACGTAGTGCCTTTCAGTGCTCGAGGCG
GCAGAACCCTGGGGTTATTAGTAAAACGATTGGAGAAAGGTGGTAAAGCTGAACATGAAAATCTTTTTCGTGAGAATGATTGCATTGTCA
GGATTAATGATGGCGACCTTCGAAATAGAAGATTTGAACAAGCACAACATATGTTTCGCCAAGCCATGCGTACACCCATCATTTGGTTCC
ATGTGGTTCCTGCAGCAAATAAAGAGCAGTATGAACAACTATCCCAAAGTGAGAAGAACAATTACTATTCAAGCCGTTTTAGCCCTGACA
GCCAGTATATTGACAACAGGAGTGTGAACAGTGCAGGGCTTCACACGGTGCAGAGAGCACCCCGACTGAACCACCCGCCTGAGCAGATAG
ACTCTCACTCAAGACTACCTCATAGCGCACACCCCTCGGGAAAACCACCATCCGCTCCAGCCTCGGCACCTCAGAATGTATTTAGTACGA
CTGTAAGCAGTGGTTATAACACCAAAAAAATAGGCAAGAGGCTTAATATCCAGCTTAAGAAAGGTACAGAAGGTTTGGGATTCAGCATCA
CTTCCAGAGATGTAACAATAGGTGGCTCAGCTCCAATCTATGTGAAAAACATTCTCCCCCGGGGGGCGGCCATTCAGGATGGCCGACTTA
AGGCAGGAGACAGACTTATAGAGGTAAATGGAGTAGATTTAGTGGGCAAATCCCAAGAGGAAGTTGTTTCGCTGTTGAGAAGCACCAAGA
TGGAAGGAACTGTGAGCCTTCTGGTCTTTCGCCAGGAAGACGCCTTCCACCCAAGGGAACTGAAAGCAGAAGATGAGGATATTGTTCTTA
CACCTGATGGCACCAGGGAATTTCTGACATTTGAAGTCCCACTTAATGATTCAGGATCTGCAGGCCTTGGTGTCAGTGTCAAAGGTAACC
GGTCAAAAGAGAACCACGCAGATTTGGGAATCTTTGTCAAGTCCATTATTAATGGAGGAGCAGCATCTAAAGATGGAAGGCTTCGGGTGA
ATGATCAACTGATAGCAGTAAATGGAGAATCCCTGTTGGGCAAGACAAACCAAGATGCCATGGAAACCCTAAGAAGGTCTATGTCTACTG
AAGGCAATAAACGAGGAATGATCCAGCTTATTGTTGCAAGGAGAATAAGCAAGTGCAATGAGCTGAAGTCACCTGGGAGCCCCCCTGGAC
CTGAGCTGCCCATTGAAACAGCGTTGGATGATAGAGAACGAAGAATTTCCCATTCCCTCTACAGTGGGATTGAGGGGCTTGATGAATCGC
CCAGCAGAAATGCTGCCCTCAGTAGGATAATGGGTAAATACCAGCTGTCCCCTACAGTGAATATGCCCCAAGATGACACTGTCATTATAG
AAGATGACAGGTTGCCAGTGCTTCCTCCACATCTCTCTGACCAGTCCTCTTCCAGCTCCCATGATGATGTGGGGTTTGTGACGGCAGATG
CTGGTACTTGGGCCAAGGCTGCAATCAGTGATTCAGCCGACTGCTCTTTGAGTCCAGATGTTGATCCAGTTCTTGCTTTTCAACGAGAAG
GATTTGGACGTCAGAGTATGTCAGAAAAACGCACAAAGCAATTTTCAGATGCCAGTCAATTGGATTTCGTTAAAACACGAAAATCAAAAA
GCATGGATTTAGGTATAGCTGACGAGACTAAACTCAATACAGTGGATGACCAGAAAGCAGGTTCTCCCAGCAGAGATGTGGGTCCTTCCC
TGGGTCTGAAGAAGTCAAGCTCGTTGGAGAGTCTGCAGACCGCAGTTGCCGAGGTGACTTTGAATGGGGATATTCCTTTCCATCGTCCAC
GGCCGCGGATAATCAGAGGCAGGGGATGCAATGAGAGCTTCAGAGCTGCCATCGACAAATCTTATGATAAACCCGCGGTAGATGATGATG
ATGAAGGCATGGAGACCTGGCAGGAAGATCCCAACAGTTTGCGCCATAAATATAACTTTATCGCGGACGTGGTGGAGAAGATCGCCCCTG
CCGTGGTTCATATCGAATTGTTTCGCAAGCTTCCGTTTTCTAAACGAGAGGTGCCGGTGGCTAGTGGGTCTGGGTTTATTGTGTCGGAAG
ATGGACTGATCGTGACAAATGCCCACGTGGTGACCAACAAGCACCGGGTCAAAGTTGAGCTGAAGAACGGTGCCACTTACGAAGCCAAAA
TCAAGGATGTGGATGAGAAAGCAGACATCGCACTCATCAAAATTGACCACCAGGGCAAGCTGCCTGTCCTGCTGCTTGGCCGCTCCTCAG
AGCTGCGGCCGGGAGAGTTCGTGGTCGCCATCGGAAGCCCGTTTTCCCTTCAAAACACAGTCACCACCGGGATCGTGAGCACCACCCAGC
GAGGCGGCAAAGAGCTGGGGCTCCGCAACTCAGACATGGACTACATCCAGACCGACGCCATCATCAACTATGGAAACTCGGGAGGCCCGT
TAGTAAACCTGGACGGTGAAGTGATTGGAATTAACACTTTGAAAGTGACAGCTGGAATCTCCTTTGCAATCCCATCTGATAAGATTAAAA
AGTTCCTCACGGAGTCCCATGACCGACAGGCCAAAGGAAAAGCCATCACCAAGAAGAAGTATATTGGTATCCGAATGATGTCACTCACGT
CCAGCAAAGCCAAAGAGCTGAAGGACCGGCACCGGGACTTCCCAGACGTGATCTCAGGAGCGTATATAATTGAAGTAATTCCTGATACCC
CAGCAGAAGCTGGTGGTCTCAAGGAAAACGACGTCATAATCAGCATCAATGGACAGTCCGTGGTCTCCGCCAATGATGTCAGCGACGTCA
TTAAAAGGGAAAGCACCCTGAACATGGTGGTCCGCAGGGGTAATGAAGATATCATGATCACAGTGATTCCCGAAGAAATTGACCCATAGG
CAGAGGCATGAGCTGGACTTCATGTTTCCCTCAAAGACTCTCCCGTGGATGACGGATGAGGACTCTGGGCTGCTGGAATAGGACACTCAA
GACTTTTGACTGCCATTTTGTTTGTTCAGTGGAGACTCCCTGGCCAACAGAATCCTTCTTGATAGTTTGCAGGCAAAACAAATGTAATGT
TGCAGATCCGCAGGCAGAAGCTCTGCCCTTCTGTATCCTATGTATGCAGTGTGCTTTTTCTTGCCAGCTTGGGCCATTCTTGCTTAGACA
GTCAGCATTTGTCTCCTCCTTTAACTGAGTCATCATCTTAGTCCAACTAATGCAGTCGATACAATGCGTAGATAGAAGAAGCCCCACGGG
AGCCAGGATGGGACTGGTCGTGTTTGTGCTTTTCTCCAAGTCAGCACCCAAAGGTCAATGCACAGAGACCCCGGGTGGGTGAGCGCTGGC
TTCTCAAACGGCCGAAGTTGCCTCTTTTAGGAATCTCTTTGGAATTGGGAGCACGATGACTCTGAGTTTGAGCTATTAAAGTACTTCTTA

>62708_62708_8_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374790_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1254AA_BP=932
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDD
MVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPA
ANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSG
YNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV
SLLVFRQEDAFHPRELKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLI
AVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNA
ALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQ
SMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRII
RGRGCNESFRAAIDKSYDKPAVDDDDEGMETWQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIV
TNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKE
LGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAK

--------------------------------------------------------------
>62708_62708_9_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374794_HTRA1_chr10_124248418_ENST00000368984_length(transcript)=4463nt_BP=2943nt
GCGGCCCCGAGCGAGCGCCAGCGCCACACAGCCCCGGGCAGCCGCCGGCGAGCGCGCCGCGACGCCGAACAGGTGGCCGGAGGCTGCGGG
CGCCGCGGCGGGGAGAGGCGAGGCAAGCCCCGGGCGAAGCGAGGCGAGGCGAGGGCGGCCGGGCCGGGCATGCGAGCTGAGCGGCCCCCC
GGCGTCGCCGCCGCCTGCCCGCGCCCCTAGCCGCCCGCGCGCCCGAGTCCCCAGCGGCTCCTCCGCGCCCAGCGTCCTCGGTCCCGGCCT
CGGCTGCTCCGGCTGCGCTCGGCGAGGGGCGCGGGCCCGCCCGCGGCGGCGGCGGCATGAAAGTGACCGTGTGCTTCGGACGGACCCGGG
TGGTCGTGCCGTGCGGGGACGGCCACATGAAAGTTTTCAGCCTCATCCAGCAGGCGGTGACCCGCTACCGGAAGGCCATCGCCAAGGATC
CAAACTACTGGATACAGGTGCATCGCTTGGAACATGGAGATGGAGGAATACTAGACCTTGATGACATTCTTTGTGATGTAGCAGACGATA
AAGACAGACTGGTAGCAGTGTTTGATGAGCAGGATCCACATCACGGAGGTGATGGCACCAGTGCCAGTTCCACGGGTACCCAGAGCCCAG
AGATATTTGGTAGTGAGCTTGGCACCAACAATGTCTCAGCCTTTCAGCCTTACCAAGCAACAAGTGAAATTGAGGTCACACCTTCAGTCC
TTCGAGCAAATATGCCTCTTCATGTTCGACGCAGTAGTGACCCAGCTCTAATTGGCCTCTCCACTTCTGTCAGTGATAGTAATTTTTCCT
CTGAAGAGCCTTCAAGGAAAAATCCCACACGCTGGTCAACAACAGCTGGCTTCCTCAAGCAGAACACTGCTGGGAGTCCTAAAACCTGCG
ACAGGAAGGATGAGGATGGGACAGAAGAGGATAACAGTCGTGTTGAACCTGTTGGACATGCTGACACGGGTTTGGAGCATATACCCAACT
TTTCTCTGGATGATATGGTAAAGCTCGTAGAAGTCCCCAACGATGGAGGGCCTCTGGGAATCCACGTAGTGCCTTTCAGTGCTCGAGGCG
GCAGAACCCTGGGGTTATTAGTAAAACGATTGGAGAAAGGTGGTAAAGCTGAACATGAAAATCTTTTTCGTGAGAATGATTGCATTGTCA
GGATTAATGATGGCGACCTTCGAAATAGAAGATTTGAACAAGCACAACATATGTTTCGCCAAGCCATGCGTACACCCATCATTTGGTTCC
ATGTGGTTCCTGCAGCAAATAAAGAGCAGTATGAACAACTATCCCAAAGTGAGAAGAACAATTACTATTCAAGCCGTTTTAGCCCTGACA
GCCAGTATATTGACAACAGGAGTGTGAACAGTGCAGGGCTTCACACGGTGCAGAGAGCACCCCGACTGAACCACCCGCCTGAGCAGATAG
ACTCTCACTCAAGACTACCTCATAGCGCACACCCCTCGGGAAAACCACCATCCGCTCCAGCCTCGGCACCTCAGAATGTATTTAGTACGA
CTGTAAGCAGTGGTTATAACACCAAAAAAATAGGCAAGAGGCTTAATATCCAGCTTAAGAAAGGTACAGAAGGTTTGGGATTCAGCATCA
CTTCCAGAGATGTAACAATAGGTGGCTCAGCTCCAATCTATGTGAAAAACATTCTCCCCCGGGGGGCGGCCATTCAGGATGGCCGACTTA
AGGCAGGAGACAGACTTATAGAGGTAAATGGAGTAGATTTAGTGGGCAAATCCCAAGAGGAAGTTGTTTCGCTGTTGAGAAGCACCAAGA
TGGAAGGAACTGTGAGCCTTCTGGTCTTTCGCCAGGAAGACGCCTTCCACCCAAGGGAACTGAAAGCAGAAGATGAGGATATTGTTCTTA
CACCTGATGGCACCAGGGAATTTCTGACATTTGAAGTCCCACTTAATGATTCAGGATCTGCAGGCCTTGGTGTCAGTGTCAAAGGTAACC
GGTCAAAAGAGAACCACGCAGATTTGGGAATCTTTGTCAAGTCCATTATTAATGGAGGAGCAGCATCTAAAGATGGAAGGCTTCGGGTGA
ATGATCAACTGATAGCAGTAAATGGAGAATCCCTGTTGGGCAAGACAAACCAAGATGCCATGGAAACCCTAAGAAGGTCTATGTCTACTG
AAGGCAATAAACGAGGAATGATCCAGCTTATTGTTGCAAGGAGAATAAGCAAGTGCAATGAGCTGAAGTCACCTGGGAGCCCCCCTGGAC
CTGAGCTGCCCATTGAAACAGCGTTGGATGATAGAGAACGAAGAATTTCCCATTCCCTCTACAGTGGGATTGAGGGGCTTGATGAATCGC
CCAGCAGAAATGCTGCCCTCAGTAGGATAATGGGTAAATACCAGCTGTCCCCTACAGTGAATATGCCCCAAGATGACACTGTCATTATAG
AAGATGACAGGTTGCCAGTGCTTCCTCCACATCTCTCTGACCAGTCCTCTTCCAGCTCCCATGATGATGTGGGGTTTGTGACGGCAGATG
CTGGTACTTGGGCCAAGGCTGCAATCAGTGATTCAGCCGACTGCTCTTTGAGTCCAGATGTTGATCCAGTTCTTGCTTTTCAACGAGAAG
GATTTGGACGTCAGAGTATGTCAGAAAAACGCACAAAGCAATTTTCAGATGCCAGTCAATTGGATTTCGTTAAAACACGAAAATCAAAAA
GCATGGATTTAGGTAGTTCTCCCAGCAGAGATGTGGGTCCTTCCCTGGGTCTGAAGAAGTCAAGCTCGTTGGAGAGTCTGCAGACCGCAG
TTGCCGAGGTGACTTTGAATGGGGATATTCCTTTCCATCGTCCACGGCCGCGGATAATCAGAGGCAGGGGATGCAATGAGAGCTTCAGAG
CTGCCATCGACAAATCTTATGATAAACCCGCGGTAGATGATGATGATGAAGGCATGGAGACCTGGCAGGAAGATCCCAACAGTTTGCGCC
ATAAATATAACTTTATCGCGGACGTGGTGGAGAAGATCGCCCCTGCCGTGGTTCATATCGAATTGTTTCGCAAGCTTCCGTTTTCTAAAC
GAGAGGTGCCGGTGGCTAGTGGGTCTGGGTTTATTGTGTCGGAAGATGGACTGATCGTGACAAATGCCCACGTGGTGACCAACAAGCACC
GGGTCAAAGTTGAGCTGAAGAACGGTGCCACTTACGAAGCCAAAATCAAGGATGTGGATGAGAAAGCAGACATCGCACTCATCAAAATTG
ACCACCAGGGCAAGCTGCCTGTCCTGCTGCTTGGCCGCTCCTCAGAGCTGCGGCCGGGAGAGTTCGTGGTCGCCATCGGAAGCCCGTTTT
CCCTTCAAAACACAGTCACCACCGGGATCGTGAGCACCACCCAGCGAGGCGGCAAAGAGCTGGGGCTCCGCAACTCAGACATGGACTACA
TCCAGACCGACGCCATCATCAACTATGGAAACTCGGGAGGCCCGTTAGTAAACCTGGACGGTGAAGTGATTGGAATTAACACTTTGAAAG
TGACAGCTGGAATCTCCTTTGCAATCCCATCTGATAAGATTAAAAAGTTCCTCACGGAGTCCCATGACCGACAGGCCAAAGGAAAAGCCA
TCACCAAGAAGAAGTATATTGGTATCCGAATGATGTCACTCACGTCCAGCAAAGCCAAAGAGCTGAAGGACCGGCACCGGGACTTCCCAG
ACGTGATCTCAGGAGCGTATATAATTGAAGTAATTCCTGATACCCCAGCAGAAGCTGGTGGTCTCAAGGAAAACGACGTCATAATCAGCA
TCAATGGACAGTCCGTGGTCTCCGCCAATGATGTCAGCGACGTCATTAAAAGGGAAAGCACCCTGAACATGGTGGTCCGCAGGGGTAATG
AAGATATCATGATCACAGTGATTCCCGAAGAAATTGACCCATAGGCAGAGGCATGAGCTGGACTTCATGTTTCCCTCAAAGACTCTCCCG
TGGATGACGGATGAGGACTCTGGGCTGCTGGAATAGGACACTCAAGACTTTTGACTGCCATTTTGTTTGTTCAGTGGAGACTCCCTGGCC
AACAGAATCCTTCTTGATAGTTTGCAGGCAAAACAAATGTAATGTTGCAGATCCGCAGGCAGAAGCTCTGCCCTTCTGTATCCTATGTAT
GCAGTGTGCTTTTTCTTGCCAGCTTGGGCCATTCTTGCTTAGACAGTCAGCATTTGTCTCCTCCTTTAACTGAGTCATCATCTTAGTCCA
ACTAATGCAGTCGATACAATGCGTAGATAGAAGAAGCCCCACGGGAGCCAGGATGGGACTGGTCGTGTTTGTGCTTTTCTCCAAGTCAGC
ACCCAAAGGTCAATGCACAGAGACCCCGGGTGGGTGAGCGCTGGCTTCTCAAACGGCCGAAGTTGCCTCTTTTAGGAATCTCTTTGGAAT

>62708_62708_9_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000374794_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1239AA_BP=917
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDD
MVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPA
ANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSG
YNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV
SLLVFRQEDAFHPRELKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLI
AVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNA
ALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQ
SMSEKRTKQFSDASQLDFVKTRKSKSMDLGSSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDK
SYDKPAVDDDDEGMETWQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVE
LKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDA
IINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISG

--------------------------------------------------------------
>62708_62708_10_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000545260_HTRA1_chr10_124248418_ENST00000368984_length(transcript)=4422nt_BP=2902nt
CCCAGCGGCCCCGAGCGAGCGCCAGCGCCACACAGCCCCGGGCAGCCGCCGGCGAGCGCGCCGCGACGCCGAACAGGTGGCCGGAGGCTG
CGGGCGCCGCGGCGGGGAGAGGCGAGGCAAGCCCCGGGCGAAGCGAGGCGAGGCGAGGGCGGCCGGGCCGGGCATGCGAGCTGAGCGGCC
CCCCGGCGTCGCCGCCGCCTGCCCGCGCCCCTAGCCGCCCGCGCGCCCGAGTCCCCAGCGGCTCCTCCGCGCCCAGCGTCCTCGGTCCCG
GCCTCGGCTGCTCCGGCTGCGCTCGGCGAGGGGCGCGGGCCCGCCCGCGGCGGCGGCGGCATGAAAGTGACCGTGTGCTTCGGACGGACC
CGGGTGGTCGTGCCGTGCGGGGACGGCCACATGAAAGTTTTCAGCCTCATCCAGCAGGCGGTGACCCGCTACCGGAAGGCCATCGCCAAG
GATCCAAACTACTGGATACAGGTGCATCGCTTGGAACATGGAGATGGAGGAATACTAGACCTTGATGACATTCTTTGTGATGTAGCAGAC
GATAAAGACAGACTGGTAGCAGTGTTTGATGAGCAGGATCCACATCACGGAGGTGATGGCACCAGTGCCAGTTCCACGGGTACCCAGAGC
CCAGAGATATTTGGTAGTGAGCTTGGCACCAACAATGTCTCAGCCTTTCAGCCTTACCAAGCAACAAGTGAAATTGAGGTCACACCTTCA
GTCCTTCGAGCAAATATGCCTCTTCATGTTCGACGCAGTAGTGACCCAGCTCTAATTGGCCTCTCCACTTCTGTCAGTGATAGTAATTTT
TCCTCTGAAGAGCCTTCAAGGAAAAATCCCACACGCTGGTCAACAACAGCTGGCTTCCTCAAGCAGAACACTGCTGGGAGTCCTAAAACC
TGCGACAGGAAGGATGAGGATGGGACAGAAGAGGATAACAGTCGTGTTGAACCTGTTGGACATGCTGACACGGGTTTGGAGCATATACCC
AACTTTTCTCTGGATGATATGGTAAAGCTCGTAGAAGTCCCCAACGATGGAGGGCCTCTGGGAATCCACGTAGTGCCTTTCAGTGCTCGA
GGCGGCAGAACCCTGGGGTTATTAGTAAAACGATTGGAGAAAGGTGGTAAAGCTGAACATGAAAATCTTTTTCGTGAGAATGATTGCATT
GTCAGGATTAATGATGGCGACCTTCGAAATAGAAGATTTGAACAAGCACAACATATGTTTCGCCAAGCCATGCGTACACCCATCATTTGG
TTCCATGTGGTTCCTGCAGCAAATAAAGAGCAGTATGAACAACTATCCCAAAGTGAGAAGAACAATTACTATTCAAGCCGTTTTAGCCCT
GACAGCCAGTATATTGACAACAGGAGTGTGAACAGTGCAGGGCTTCACACGGTGCAGAGAGCACCCCGACTGAACCACCCGCCTGAGCAG
ATAGACTCTCACTCAAGACTACCTCATAGCGCACACCCCTCGGGAAAACCACCATCCGCTCCAGCCTCGGCACCTCAGAATGTATTTAGT
ACGACTGTAAGCAGTGGTTATAACACCAAAAAAATAGGCAAGAGGCTTAATATCCAGCTTAAGAAAGGTACAGAAGGTTTGGGATTCAGC
ATCACTTCCAGAGATGTAACAATAGGTGGCTCAGCTCCAATCTATGTGAAAAACATTCTCCCCCGGGGGGCGGCCATTCAGGATGGCCGA
CTTAAGGCAGGAGACAGACTTATAGAGGTAAATGGAGTAGATTTAGTGGGCAAATCCCAAGAGGAAGTTGTTTCGCTGTTGAGAAGCACC
AAGATGGAAGGAACTGTGAGCCTTCTGGTCTTTCGCCAGGAAGACGCCTTCCACCCAAGGGAACTGAAAGCAGAAGATGAGGATATTGTT
CTTACACCTGATGGCACCAGGGAATTTCTGACATTTGAAGTCCCACTTAATGATTCAGGATCTGCAGGCCTTGGTGTCAGTGTCAAAGGT
AACCGGTCAAAAGAGAACCACGCAGATTTGGGAATCTTTGTCAAGTCCATTATTAATGGAGGAGCAGCATCTAAAGATGGAAGGCTTCGG
GTGAATGATCAACTGATAGCAGTAAATGGAGAATCCCTGTTGGGCAAGACAAACCAAGATGCCATGGAAACCCTAAGAAGGTCTATGTCT
ACTGAAGGCAATAAACGAGGAATGATCCAGCTTATTGTTGCAAGGAGAATAAGCAAGTGCAATGAGCTGAAGTCACCTGGGAGCCCCCCT
GGACCTGAGCTGCCCATTGAAACAGCGTTGGATGATAGAGAACGAAGAATTTCCCATTCCCTCTACAGTGGGATTGAGGGGCTTGATGAA
TCGCCCAGCAGAAATGCTGCCCTCAGTAGGATAATGGGTAAATACCAGCTGTCCCCTACAGTGAATATGCCCCAAGATGACACTGTCATT
ATAGAAGATGACAGGTTGCCAGTGCTTCCTCCACATCTCTCTGACCAGTCCTCTTCCAGCTCCCATGATGATGTGGGGTTTGTGACGGCA
GATGCTGGTACTTGGGCCAAGGCTGCAATCAGTGATTCAGCCGACTGCTCTTTGAGTCCAGATGTTGATCCAGTTCTTGCTTTTCAACGA
GAAGGATTTGGACGTCAGATAGCTGACGAGACTAAACTCAATACAGTGGATGACCAGAAAGCAGGTTCTCCCAGCAGAGATGTGGGTCCT
TCCCTGGGTCTGAAGAAGTCAAGCTCGTTGGAGAGTCTGCAGACCGCAGTTGCCGAGGTGACTTTGAATGGGGATATTCCTTTCCATCGT
CCACGGCCGCGGATAATCAGAGGCAGGGGATGCAATGAGAGCTTCAGAGCTGCCATCGACAAATCTTATGATAAACCCGCGGTAGATGAT
GATGATGAAGGCATGGAGACCTGGCAGGAAGATCCCAACAGTTTGCGCCATAAATATAACTTTATCGCGGACGTGGTGGAGAAGATCGCC
CCTGCCGTGGTTCATATCGAATTGTTTCGCAAGCTTCCGTTTTCTAAACGAGAGGTGCCGGTGGCTAGTGGGTCTGGGTTTATTGTGTCG
GAAGATGGACTGATCGTGACAAATGCCCACGTGGTGACCAACAAGCACCGGGTCAAAGTTGAGCTGAAGAACGGTGCCACTTACGAAGCC
AAAATCAAGGATGTGGATGAGAAAGCAGACATCGCACTCATCAAAATTGACCACCAGGGCAAGCTGCCTGTCCTGCTGCTTGGCCGCTCC
TCAGAGCTGCGGCCGGGAGAGTTCGTGGTCGCCATCGGAAGCCCGTTTTCCCTTCAAAACACAGTCACCACCGGGATCGTGAGCACCACC
CAGCGAGGCGGCAAAGAGCTGGGGCTCCGCAACTCAGACATGGACTACATCCAGACCGACGCCATCATCAACTATGGAAACTCGGGAGGC
CCGTTAGTAAACCTGGACGGTGAAGTGATTGGAATTAACACTTTGAAAGTGACAGCTGGAATCTCCTTTGCAATCCCATCTGATAAGATT
AAAAAGTTCCTCACGGAGTCCCATGACCGACAGGCCAAAGGAAAAGCCATCACCAAGAAGAAGTATATTGGTATCCGAATGATGTCACTC
ACGTCCAGCAAAGCCAAAGAGCTGAAGGACCGGCACCGGGACTTCCCAGACGTGATCTCAGGAGCGTATATAATTGAAGTAATTCCTGAT
ACCCCAGCAGAAGCTGGTGGTCTCAAGGAAAACGACGTCATAATCAGCATCAATGGACAGTCCGTGGTCTCCGCCAATGATGTCAGCGAC
GTCATTAAAAGGGAAAGCACCCTGAACATGGTGGTCCGCAGGGGTAATGAAGATATCATGATCACAGTGATTCCCGAAGAAATTGACCCA
TAGGCAGAGGCATGAGCTGGACTTCATGTTTCCCTCAAAGACTCTCCCGTGGATGACGGATGAGGACTCTGGGCTGCTGGAATAGGACAC
TCAAGACTTTTGACTGCCATTTTGTTTGTTCAGTGGAGACTCCCTGGCCAACAGAATCCTTCTTGATAGTTTGCAGGCAAAACAAATGTA
ATGTTGCAGATCCGCAGGCAGAAGCTCTGCCCTTCTGTATCCTATGTATGCAGTGTGCTTTTTCTTGCCAGCTTGGGCCATTCTTGCTTA
GACAGTCAGCATTTGTCTCCTCCTTTAACTGAGTCATCATCTTAGTCCAACTAATGCAGTCGATACAATGCGTAGATAGAAGAAGCCCCA
CGGGAGCCAGGATGGGACTGGTCGTGTTTGTGCTTTTCTCCAAGTCAGCACCCAAAGGTCAATGCACAGAGACCCCGGGTGGGTGAGCGC
TGGCTTCTCAAACGGCCGAAGTTGCCTCTTTTAGGAATCTCTTTGGAATTGGGAGCACGATGACTCTGAGTTTGAGCTATTAAAGTACTT

>62708_62708_10_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000545260_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1224AA_BP=902
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDD
MVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPA
ANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSG
YNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV
SLLVFRQEDAFHPRELKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLI
AVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNA
ALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQ
IADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGME
TWQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVD
EKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLD
GEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAG

--------------------------------------------------------------
>62708_62708_11_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000545693_HTRA1_chr10_124248418_ENST00000368984_length(transcript)=4644nt_BP=3124nt
CCCAGCGGCCCCGAGCGAGCGCCAGCGCCACACAGCCCCGGGCAGCCGCCGGCGAGCGCGCCGCGACGCCGAACAGGTGGCCGGAGGCTG
CGGGCGCCGCGGCGGGGAGAGGCGAGGCAAGCCCCGGGCGAAGCGAGGCGAGGCGAGGGCGGCCGGGCCGGGCATGCGAGCTGAGCGGCC
CCCCGGCGTCGCCGCCGCCTGCCCGCGCCCCTAGCCGCCCGCGCGCCCGAGTCCCCAGCGGCTCCTCCGCGCCCAGCGTCCTCGGTCCCG
GCCTCGGCTGCTCCGGCTGCGCTCGGCGAGGGGCGCGGGCCCGCCCGCGGCGGCGGCGGCATGAAAGTGACCGTGTGCTTCGGACGGACC
CGGGTGGTCGTGCCGTGCGGGGACGGCCACATGAAAGTTTTCAGCCTCATCCAGCAGGCGGTGACCCGCTACCGGAAGGCCATCGCCAAG
GATCCAAACTACTGGATACAGGTGCATCGCTTGGAACATGGAGATGGAGGAATACTAGACCTTGATGACATTCTTTGTGATGTAGCAGAC
GATAAAGACAGACTGGTAGCAGTGTTTGATGAGCAGGATCCACATCACGGAGGTGATGGCACCAGTGCCAGTTCCACGGGTACCCAGAGC
CCAGAGATATTTGGTAGTGAGCTTGGCACCAACAATGTCTCAGCCTTTCAGCCTTACCAAGCAACAAGTGAAATTGAGGTCACACCTTCA
GTCCTTCGAGCAAATATGCCTCTTCATGTTCGACGCAGTAGTGACCCAGCTCTAATTGGCCTCTCCACTTCTGTCAGTGATAGTAATTTT
TCCTCTGAAGAGCCTTCAAGGAAAAATCCCACACGCTGGTCAACAACAGCTGGCTTCCTCAAGCAGAACACTGCTGGGAGTCCTAAAACC
TGCGACAGGAAGAAAGATGAAAACTACAGAAGCCTCCCGCGGGATACTAGTAACTGGTCTAACCAATTTCAGAGAGACAATGCTCGCTCG
TCTCTGAGTGCCAGTCACCCAATGGTGGGCAAGTGGCTGGAGAAACAAGAACAGGATGAGGATGGGACAGAAGAGGATAACAGTCGTGTT
GAACCTGTTGGACATGCTGACACGGGTTTGGAGCATATACCCAACTTTTCTCTGGATGATATGGTAAAGCTCGTAGAAGTCCCCAACGAT
GGAGGGCCTCTGGGAATCCACGTAGTGCCTTTCAGTGCTCGAGGCGGCAGAACCCTGGGGTTATTAGTAAAACGATTGGAGAAAGGTGGT
AAAGCTGAACATGAAAATCTTTTTCGTGAGAATGATTGCATTGTCAGGATTAATGATGGCGACCTTCGAAATAGAAGATTTGAACAAGCA
CAACATATGTTTCGCCAAGCCATGCGTACACCCATCATTTGGTTCCATGTGGTTCCTGCAGCAAATAAAGAGCAGTATGAACAACTATCC
CAAAGTGAGAAGAACAATTACTATTCAAGCCGTTTTAGCCCTGACAGCCAGTATATTGACAACAGGAGTGTGAACAGTGCAGGGCTTCAC
ACGGTGCAGAGAGCACCCCGACTGAACCACCCGCCTGAGCAGATAGACTCTCACTCAAGACTACCTCATAGCGCACACCCCTCGGGAAAA
CCACCATCCGCTCCAGCCTCGGCACCTCAGAATGTATTTAGTACGACTGTAAGCAGTGGTTATAACACCAAAAAAATAGGCAAGAGGCTT
AATATCCAGCTTAAGAAAGGTACAGAAGGTTTGGGATTCAGCATCACTTCCAGAGATGTAACAATAGGTGGCTCAGCTCCAATCTATGTG
AAAAACATTCTCCCCCGGGGGGCGGCCATTCAGGATGGCCGACTTAAGGCAGGAGACAGACTTATAGAGGTAAATGGAGTAGATTTAGTG
GGCAAATCCCAAGAGGAAGTTGTTTCGCTGTTGAGAAGCACCAAGATGGAAGGAACTGTGAGCCTTCTGGTCTTTCGCCAGGAAGACGCC
TTCCACCCAAGGGAACTGAAAGCAGAAGATGAGGATATTGTTCTTACACCTGATGGCACCAGGGAATTTCTGACATTTGAAGTCCCACTT
AATGATTCAGGATCTGCAGGCCTTGGTGTCAGTGTCAAAGGTAACCGGTCAAAAGAGAACCACGCAGATTTGGGAATCTTTGTCAAGTCC
ATTATTAATGGAGGAGCAGCATCTAAAGATGGAAGGCTTCGGGTGAATGATCAACTGATAGCAGTAAATGGAGAATCCCTGTTGGGCAAG
ACAAACCAAGATGCCATGGAAACCCTAAGAAGGTCTATGTCTACTGAAGGCAATAAACGAGGAATGATCCAGCTTATTGTTGCAAGGAGA
ATAAGCAAGTGCAATGAGCTGAAGTCACCTGGGAGCCCCCCTGGACCTGAGCTGCCCATTGAAACAGCGTTGGATGATAGAGAACGAAGA
ATTTCCCATTCCCTCTACAGTGGGATTGAGGGGCTTGATGAATCGCCCAGCAGAAATGCTGCCCTCAGTAGGATAATGGGTAAATACCAG
CTGTCCCCTACAGTGAATATGCCCCAAGATGACACTGTCATTATAGAAGATGACAGGTTGCCAGTGCTTCCTCCACATCTCTCTGACCAG
TCCTCTTCCAGCTCCCATGATGATGTGGGGTTTGTGACGGCAGATGCTGGTACTTGGGCCAAGGCTGCAATCAGTGATTCAGCCGACTGC
TCTTTGAGTCCAGATGTTGATCCAGTTCTTGCTTTTCAACGAGAAGGATTTGGACGTCAGAGTATGTCAGAAAAACGCACAAAGCAATTT
TCAGATGCCAGTCAATTGGATTTCGTTAAAACACGAAAATCAAAAAGCATGGATTTAGGTATAGCTGACGAGACTAAACTCAATACAGTG
GATGACCAGAAAGCAGGTTCTCCCAGCAGAGATGTGGGTCCTTCCCTGGGTCTGAAGAAGTCAAGCTCGTTGGAGAGTCTGCAGACCGCA
GTTGCCGAGGTGACTTTGAATGGGGATATTCCTTTCCATCGTCCACGGCCGCGGATAATCAGAGGCAGGGGATGCAATGAGAGCTTCAGA
GCTGCCATCGACAAATCTTATGATAAACCCGCGGTAGATGATGATGATGAAGGCATGGAGACCTGGCAGGAAGATCCCAACAGTTTGCGC
CATAAATATAACTTTATCGCGGACGTGGTGGAGAAGATCGCCCCTGCCGTGGTTCATATCGAATTGTTTCGCAAGCTTCCGTTTTCTAAA
CGAGAGGTGCCGGTGGCTAGTGGGTCTGGGTTTATTGTGTCGGAAGATGGACTGATCGTGACAAATGCCCACGTGGTGACCAACAAGCAC
CGGGTCAAAGTTGAGCTGAAGAACGGTGCCACTTACGAAGCCAAAATCAAGGATGTGGATGAGAAAGCAGACATCGCACTCATCAAAATT
GACCACCAGGGCAAGCTGCCTGTCCTGCTGCTTGGCCGCTCCTCAGAGCTGCGGCCGGGAGAGTTCGTGGTCGCCATCGGAAGCCCGTTT
TCCCTTCAAAACACAGTCACCACCGGGATCGTGAGCACCACCCAGCGAGGCGGCAAAGAGCTGGGGCTCCGCAACTCAGACATGGACTAC
ATCCAGACCGACGCCATCATCAACTATGGAAACTCGGGAGGCCCGTTAGTAAACCTGGACGGTGAAGTGATTGGAATTAACACTTTGAAA
GTGACAGCTGGAATCTCCTTTGCAATCCCATCTGATAAGATTAAAAAGTTCCTCACGGAGTCCCATGACCGACAGGCCAAAGGAAAAGCC
ATCACCAAGAAGAAGTATATTGGTATCCGAATGATGTCACTCACGTCCAGCAAAGCCAAAGAGCTGAAGGACCGGCACCGGGACTTCCCA
GACGTGATCTCAGGAGCGTATATAATTGAAGTAATTCCTGATACCCCAGCAGAAGCTGGTGGTCTCAAGGAAAACGACGTCATAATCAGC
ATCAATGGACAGTCCGTGGTCTCCGCCAATGATGTCAGCGACGTCATTAAAAGGGAAAGCACCCTGAACATGGTGGTCCGCAGGGGTAAT
GAAGATATCATGATCACAGTGATTCCCGAAGAAATTGACCCATAGGCAGAGGCATGAGCTGGACTTCATGTTTCCCTCAAAGACTCTCCC
GTGGATGACGGATGAGGACTCTGGGCTGCTGGAATAGGACACTCAAGACTTTTGACTGCCATTTTGTTTGTTCAGTGGAGACTCCCTGGC
CAACAGAATCCTTCTTGATAGTTTGCAGGCAAAACAAATGTAATGTTGCAGATCCGCAGGCAGAAGCTCTGCCCTTCTGTATCCTATGTA
TGCAGTGTGCTTTTTCTTGCCAGCTTGGGCCATTCTTGCTTAGACAGTCAGCATTTGTCTCCTCCTTTAACTGAGTCATCATCTTAGTCC
AACTAATGCAGTCGATACAATGCGTAGATAGAAGAAGCCCCACGGGAGCCAGGATGGGACTGGTCGTGTTTGTGCTTTTCTCCAAGTCAG
CACCCAAAGGTCAATGCACAGAGACCCCGGGTGGGTGAGCGCTGGCTTCTCAAACGGCCGAAGTTGCCTCTTTTAGGAATCTCTTTGGAA

>62708_62708_11_PARD3-HTRA1_PARD3_chr10_34620045_ENST00000545693_HTRA1_chr10_124248418_ENST00000368984_length(amino acids)=1298AA_BP=976
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWI
QVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM
PLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASH
PMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHEN
LFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAP
RLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR
GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELKAEDEDIVLTPDGTREFLTFEVPLNDSGSA
GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNE
LKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSH
DDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAG
SPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETWQEDPNSLRHKYNFI
ADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKL
PVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGIS
FAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSV

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Fusion Gene PPI Analysis for PARD3-HTRA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-1921712_936944.33333333333341032.0PRKCI and PRKCZ
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-1924712_936947.33333333333341320.0PRKCI and PRKCZ
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-1925712_936944.33333333333341354.0PRKCI and PRKCZ
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-1925712_936947.33333333333341357.0PRKCI and PRKCZ


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePARD3chr10:34620045chr10:124248418ENST00000340077-1921935_1356944.33333333333341032.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000346874-1924935_1356947.33333333333341320.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-1824935_1356901.33333333333341311.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-1820935_1356901.3333333333334989.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000374788-1925935_1356944.33333333333341354.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000374789-1925935_1356947.33333333333341357.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-1621935_1356872.33333333333341245.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-1723935_1356857.33333333333341267.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-1824935_1356931.33333333333341341.0FRMD4A
HgenePARD3chr10:34620045chr10:124248418ENST00000350537-1824712_936901.33333333333341311.0PRKCI and PRKCZ
HgenePARD3chr10:34620045chr10:124248418ENST00000374776-1820712_936901.3333333333334989.0PRKCI and PRKCZ
HgenePARD3chr10:34620045chr10:124248418ENST00000374794-1621712_936872.33333333333341245.0PRKCI and PRKCZ
HgenePARD3chr10:34620045chr10:124248418ENST00000545260-1723712_936857.33333333333341267.0PRKCI and PRKCZ
HgenePARD3chr10:34620045chr10:124248418ENST00000545693-1824712_936931.33333333333341341.0PRKCI and PRKCZ


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PARD3-HTRA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PARD3-HTRA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource