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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PARG-BMS1 (FusionGDB2 ID:62738)

Fusion Gene Summary for PARG-BMS1

Fusion gene summary

Fusion gene information	Fusion gene name: PARG-BMS1
	Fusion gene ID: 62738
		Hgene	Tgene
	Gene symbol	PARG	BMS1
	Gene ID	8505	9790
	Gene name	poly(ADP-ribose) glycohydrolase	BMS1 ribosome biogenesis factor
	Synonyms	PARG99	ACC\|BMS1L
	Cytomap	10q11.23	10q11.21
	Type of gene	protein-coding	protein-coding
	Description	poly(ADP-ribose) glycohydrolasemitochondrial poly(ADP-ribose) glycohydrolasepoly(ADP-ribose) glycohydrolase 60 kDa isoform	ribosome biogenesis protein BMS1 homologBMS1 homolog, ribosome assembly proteinBMS1-like, ribosome assembly proteinribosome assembly protein BMS1 homolog
	Modification date	20200313	20200313
	UniProtAcc	.	Q14692
	Ensembl transtripts involved in fusion gene	ENST00000402038, ENST00000492350,	ENST00000374518,
Fusion gene scores	* DoF score	4 X 3 X 4=48	6 X 6 X 3=108
	# samples	4	6
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PARG [Title/Abstract] AND BMS1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PARG(51093249)-BMS1(43287075), # samples:4
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PARG	GO:1990966	ATP generation from poly-ADP-D-ribose	27257257

Fusion gene breakpoints across PARG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BMS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	DLBC	TCGA-FA-A7DS	PARG	chr10	51093249	-	BMS1	chr10	43287075	+
ChimerDB4	KIRP	TCGA-J7-8537	PARG	chr10	51093249	-	BMS1	chr10	43287075	+
ChimerDB4	STAD	TCGA-HU-8610-01A	PARG	chr10	51093249	-	BMS1	chr10	43287075	+
ChimerDB4	THCA	TCGA-DJ-A2Q3-01A	PARG	chr10	51093249	-	BMS1	chr10	43287075	+

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Fusion Gene ORF analysis for PARG-BMS1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000402038	ENST00000374518	PARG	chr10	51093249	-	BMS1	chr10	43287075	+
intron-3CDS	ENST00000492350	ENST00000374518	PARG	chr10	51093249	-	BMS1	chr10	43287075	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000402038

PARG

chr10

51093249

ENST00000374518

BMS1

chr10

43287075

7429

375

3587

1192

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000402038	ENST00000374518	PARG	chr10	51093249	-	BMS1	chr10	43287075	+	0.00035871	0.9996413

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Fusion Genomic Features for PARG-BMS1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PARG	chr10	51093248	-	BMS1	chr10	43287074	+	0.036884293	0.96311575
PARG	chr10	51093248	-	BMS1	chr10	43287074	+	0.036884293	0.96311575
PARG	chr10	51093248	-	BMS1	chr10	43287074	+	0.036884293	0.96311575
PARG	chr10	51093248	-	BMS1	chr10	43287074	+	0.036884293	0.96311575

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PARG-BMS1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:51093249/chr10:43287075)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	BMS1 Q14692
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus. {ECO:0000250\|UniProtKB:Q08965}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PARG

chr10:51093249

chr10:43287075

ENST00000402038

10_16

125

492.0

Motif

Nuclear localization signal

Hgene

PARG

chr10:51093249

chr10:43287075

ENST00000402038

76_83

125

492.0

Motif

PIP-box (PCNA interacting peptide)

Tgene

BMS1

chr10:51093249

chr10:43287075

ENST00000374518

219_228

212

1283.0

Region

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PARG

chr10:51093249

chr10:43287075

ENST00000402038

1_456

125

492.0

Region

A-domain

Hgene

PARG

chr10:51093249

chr10:43287075

ENST00000402038

610_795

125

492.0

Region

Catalytic

Hgene

PARG

chr10:51093249

chr10:43287075

ENST00000402038

726_727

125

492.0

Region

Substrate binding

Hgene

PARG

chr10:51093249

chr10:43287075

ENST00000402038

869_874

125

492.0

Region

Substrate binding

Tgene

BMS1

chr10:51093249

chr10:43287075

ENST00000374518

80_245

212

1283.0

Domain

Bms1-type G

Tgene

BMS1

chr10:51093249

chr10:43287075

ENST00000374518

117_121

212

1283.0

Region

Tgene

BMS1

chr10:51093249

chr10:43287075

ENST00000374518

132_135

212

1283.0

Region

Tgene

BMS1

chr10:51093249

chr10:43287075

ENST00000374518

184_187

212

1283.0

Region

Tgene

BMS1

chr10:51093249

chr10:43287075

ENST00000374518

89_96

212

1283.0

Region

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Fusion Gene Sequence for PARG-BMS1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>62738_62738_1_PARG-BMS1_PARG_chr10_51093249_ENST00000402038_BMS1_chr10_43287075_ENST00000374518_length(transcript)=7429nt_BP=375nt
GTAGATCTTTTGCGAGCAGGAGAAGTTCCTAAACCTTTTCCAACACATTATAAAGATTTGTGGGATAACAAGCATGTTAAAATGCCTTGT
TCAGAACAAAATTTGTACCCAGTGGAAGATGAGAATGGTGAGCGAACTGCGGGGAGCCGGTGGGAGCTCATTCAGACTGCACTTCTCAAC
AAATTTACACGACCCCAAAACTTGAAGGATGCTATTCTGAAATACAATGTGGCATATTCTAAGAAATGGGACTTTACAGCTTTGATCGAT
TTCTGGGATAAGGTACTTGAAGAAGCAGAAGCTCAACATTTATATCAGTCCATCTTGCCTGATATGGTGAAAATTGCACTCTGTCTGCCA
AATATTTGCACCCAGGGTGCCAAGCTGTTCTACCTTTCTGGAATGGTGCATGGAGAATATCAAAACCAAGAAATCCACAATCTGGGCCGT
TTTATTACAGTTATGAAGTTTAGGCCTCTCACATGGCAAACTTCTCACCCTTATATCCTGGCAGACAGGATGGAAGATTTGACAAACCCA
GAGGATATCCGAACAAACATCAAATGTGACCGGAAGGTGTCACTTTATGGTTATTTAAGAGGAGCACACTTGAAAAATAAAAGCCAAATT
CACATGCCAGGGGTAGGAGATTTTGCCGTGAGTGACATCAGTTTCCTCCCAGACCCTTGCGCTCTTCCTGAACAACAAAAGAAGCGCTGT
TTAAATGAGAAGGAGAAGCTGGTTTATGCGCCTCTTTCTGGAGTTGGGGGTGTGCTGTATGACAAAGACGCTGTCTATGTTGACCTTGGT
GGCAGCCACGTTTTTCAGGATGAAGTGGGGCCCACCCATGAGCTGGTCCAGAGTCTCATCTCTACCCACTCCACCATTGATGCCAAGATG
GCTTCAAGTCGAGTGACGCTGTTTTCTGATTCCAAGCCACTTGGGTCAGAGGATATAGATAATCAAGGGCTAATGATGCCAAAGGAGGAA
AAACAAATGGACTTGAACACTGGTCGAATGCGTCGGAAAGCCATTTTCGGAGATGAAGATGAATCTGGAGATAGTGATGATGAAGAAGAT
GATGAAATGTCTGAAGATGACGGGTTGGAAAACGGCTCTAGTGATGAGGAAGCAGAAGAGGAGGAAAATGCTGAGATGACTGATCAGTAT
ATGGCTGTTAAGGGCATCAAACGACGGAAACTTGAGTTGGAAGAAGACAGTGAAATGGATTTGCCAGCATTTGCTGACAGTGACGATGAC
CTTGAGAGGAGCTCAGCGGAAGAAGGGGAAGCGGAGGAAGCTGATGAAAGCAGTGAAGAAGAGGACTGCACTGCAGGAGAGAAGGGCATT
TCAGGATCAAAGGCTGCTGGAGAAGGTAGTAAAGCAGGGCTGTCACCAGCTAATTGCCAGAGTGACCGTGTGAATCTGGAGAAGTCTTTG
CTGATGAAGAAAGCAGCTCTCCCCACTTTCGATTCTGGGCATTGCACAGCTGAAGAGGTGTTTGCATCTGAAGATGAATCTGAAGAAAGC
TCCTCACTCAGTGCAGAGGAAGAAGACTCAGAAAATGAAGAGGCTATTAGAAAAAAGCTTTCAAAGCCTTCTCAAGTGAGCAGTGGTCAG
AAACTGGGGCCACAGAACTTCATTGATGAGACCAGTGATATAGAAAATTTACTCAAAGAGGAAGAAGATTACAAGGAAGAAAATAATGAT
TCCAAAGAAACGTCAGGTGCCCTCAAGTGGAAGGAAGACCTTTCCAGAAAGGCAGCTGAGGCCTTTCTGAGGCAGCAGCAAGCAGCTCCA
AACCTCCGAAAGCTTATTTATGGGACAGTGACAGAAGATAATGAAGAAGAAGATGATGATACTCTAGAAGAGCTTGGAGGGTTGTTTCGT
GTCAACCAGCCTGACAGAGAGTGTAAGCACAAGGCTGACTCTTTGGACTGCTCCAGATTTCTTGTGGAGGCCCCCCATGACTGGGATTTA
GAGGAGGTTATGAACAGTATCAGAGATTGCTTCGTGACTGGAAAGTGGGAAGATGATAAAGATGCAGCCAAGGTCTTAGCAGAAGATGAG
GAGCTCTACGGTGACTTTGAAGACTTGGAAACAGGGGACGTGCACAAGGGAAAATCAGGCCCCAATACTCAGAATGAAGATATAGAGAAA
GAAGTTAAGGAAGAAATTGACCCCGACGAAGAAGAAAGTGCCAAGAAAAAGCATTTGGATAAGAAGAGAAAATTGAAGGAGATGTTTGAT
GCAGAATATGATGAAGGAGAAAGCACATATTTTGATGATCTTAAAGGAGAAATGCAGAAACAAGCACAGCTGAATCGCGCAGAATTTGAA
GATCAAGATGATGAAGCCAGAGTTCAGTATGAGGGTTTTCGACCTGGGATGTACGTCCGCATTGAGATTGAAAATGTTCCCTGTGAATTT
GTGCAGAACTTTGACCCCCATTACCCCATTATCCTGGGTGGCTTGGGCAACAGTGAGGGAAATGTTGGCTACGTGCAGATGCGTCTGAAG
AAACATCGCTGGTATAAGAAAATCCTCAAGTCCCGAGATCCAATCATATTTTCTGTAGGGTGGAGGAGGTTTCAGACCATCCCACTGTAT
TATATCGAAGACCACAATGGAAGACAAAGGCTTCTAAAGTATACCCCACAGCACATGCATTGCGGAGCAGCCTTTTGGGGCCCTATCACT
CCACAGGGAACTGGTTTCTTGGCAATACAGTCTGTCAGTGGCATAATGCCTGATTTTCGGATAGCTGCTACAGGAGTTGTCCTTGATCTG
GATAAATCCATAAAAATTGTGAAGAAATTAAAGCTAACTGGTTTTCCATATAAAATTTTCAAGAACACTTCATTTATTAAGGGAATGTTT
AATTCTGCCTTGGAAGTGGCCAAATTTGAAGGTGCTGTGATTCGAACAGTCAGTGGGATAAGGGGGCAGATCAAGAAAGCACTCCGAGCT
CCAGAAGGAGCTTTCAGGGCCAGCTTTGAGGATAAGCTGCTGATGAGCGATATTGTCTTCATGCGAACTTGGTATCCTGTTTCCATCCCA
GCGTTCTATAACCCAGTAACATCTTTGTTGAAACCAGTGGGTGAGAAAGACACCTGGTCAGGAATGCGGACCACGGGCCAACTCAGGCTC
GCCCATGGCGTCAGACTAAAGGCGAACAAGGACTCTCTGTATAAGCCAATCCTGAGGCAAAAGAAACATTTTAATTCACTGCACATTCCA
AAAGCCTTGCAGAAGGCCCTGCCATTTAAGAACAAGCCCAAGACCCAAGCAAAGGCAGGCAAGGTGCCAAAGGACAGGCGGAGACCGGCC
GTCATACGCGAGCCTCATGAAAGAAAGATCCTTGCACTGCTGGATGCTCTGAGTACGGTGCATAGTCAGAAGATGAAGAAGGCCAAGGAG
CAGCGGCACCTGCACAATAAAGAGCACTTCAGAGCCAAGCAGAAGGAGGAGGAGGAGAAGCTGAAGCGGCAGAAGGACCTCAGGAAGAAG
CTCTTCAGAATTCAGGGGCAGAAGGAAAGAAGAAACCAGAAGTCCAGTTTGAAGGGGGCTGAGGGCCAATTGCAGTGAGCCTTTGGACTG
GAGGGACTGTCCCTGGATCTGCGGAGGTAGACAGTTTCAAACATCACAGTTTGAATGCCTGTGAATGACAAGTCAGTGGGAAAGAGCTCA
AGAGATGTCTCTACTCAAACTGTGCCTGCAGGAGGAGGAACAGAGAAGCCTGGGCTGCTGGGACTGGGTTCATTCTCATGACTTGGGGCT
GTCGAGATTTAAAGTGATGTAAGCTGTGGTTATGTGGATTCTCTTACTTTCCTCTGCCTGCCTCAGTTTAATTATTTTGTCCTACAGAAA
TATCATTAAAATATTTTTTTGTTACTTTTGGCTTAGTAGTTTTCATTAGGGATGAATGCCTGACAATTCTTTGTGGATAATTATTTATAC
TACCACCTTCATGAGGAGTCTTCCAGAAGAGAAAGAAATATTCACTTGAACTCTGAGCTCCCATGGAAGATTTTAGAGAATAGTGTGTAG
TGTTTTTGTTTTGTTTTTTGTTTGAGTGACACACAAACCTAGATGGTACAGCCTACTGTGCACCCAGGATCTATGGGCTCCTTTGATCAC
TGGCCCTTGTGGACATTTTCTATCTTATTTCATATGTTCTGCACATTAGTATAGTGACAAGGTAACAGTAAGTACTTTTTTAAAGCTTTA
GACTTAGGAGATTATTGTCTCAGGTGCAGAGACCAAGGAAATCGTATGTATCAGTGAGATAGGCTTCCCGTATTATGCTCATGCGTTATA
CCTGCCTAGCTACATTGCCTTTTTTTAAATTAAACATTATGTTGAAGTAATCATACTATTACATAGGCGATGTATGTATTTTATGATTGT
ATGTTGATATAGTTATGGGGAATCTATTCCTATACGATGTAATCATAGATTCACATATAGTTGTATATTTTGCCCAATTTCTCTCAGTGG
TAATGTTTCACACATATAACAATCAGGATGTTGACATCAATACAGCCCGCTGATTTTATTCACATTTCCCCAGCTTTACTTTCCCCAACG
TATACTCCTCCATGTATGCATGGGTGTGTAGAAATATGGAACGCAGCTGGGCACAGTGACTCACGCCTGTAATCCCAGCACTTTGGGATG
CTAAGGCAGGAGGATCACTTGAGCCCAGGAATTTGAGACCAACTTGGGCAACATGGCAAAACCTCATCGCTACAAAAAATAAAAAATTCG
CCAGGTGTGGTGGGTGCACACCTGTAGTTCCAGCTGCTTGGGAGGCTGAGGTAGGAGGATCACTTGAGCTTGGGAGGTTGAGGCTGCAGT
GAGCCATGATAGCACCACTGCACTCCAGCCTGGGCGACAGGGCAAGACCCTGTTTCAAAAAAAAAAAATTATACATATATGTATGTAGAA
CACTTCATGAATTTGTGTGTCATCTGTGCATGGGGCCCATGCTGACCTCTGTGTTGTGCCAGTTATAGTATGTGTGCTGCTGATATGAGT
GCCACATTGCCTTTACAACATCATAGGGGCCAAAGAGGGTTGGCAGGATTATGAGCAGTTGGCCTAGTCTGAGAGGCTCTCTAAAAGCCT
AAAGTCTGTAGGCAGGTGCTCAGCTTTGTATCTCCATAAGAAGGGAAGAGGATGTGAGGATCCTGTCAGGGCTAGGTCCACCTGGGAAGT
GACAATTGGAACACTCCCAGACCTCTCTGGGCAACTCTGGGTGTACATTTTCCTCTGTTCCTCAAGAGCTATTATGAATTTCATCATCCA
TTATGCTGATAGGCCTGGGGACTGACACATAGTAAGCCCATAACAATTATAATTTAAAACTAATTTGTTATATAGCATAATTGATATATT
TTAAAATGCAAAACTATAATTCAACTAAAATATACAAGGCACTCAAGTCATACCATGTTTTAAGTAGCTTACAAGGTGATCAGCAAGTGT
CTTATACAACAAGCAAATTTGTTCAAAGAGAAGCATTGCAAATAAGTATTTATAATTGTATAGTTTTATATTTTAGCCAGAAGAGTGGAA
TCCTTTAGCAATGGGGGAAATAAAAGAATGTTTAATTACAGTTGCAGATAATTGCCTTTTCCAAAGACAATGTATGTAGGCAGAACTCAT
ACCTGTTAATATTAAAAATCTTGGTTTATCATATTTGGAGAACAAGGGAAATAAAAAGTTTGCATATTAAGATTATTTAAACTAAAGTTA
AGGAATCTCTAATGTCTGAAAGAAACAATAAATAGCATTTTTCATGTAGAATTTTTATTGGTGAAGGTTCCACCTGGCCAGGTTAGTAAA
ATACAGTCACACATCAGTTAAGGATGGGGATATATTCTGAGAAATGTATCATTAGGCAATTTTGTCATTGTGTAAACATCATAGAGTGAC
ACACAAACCTAGATGGTACAGCCTACTGTGCACCTGGGCTCTATGGTATGGCCTGTTGCTCCTAGGCTACAAACCTGGGCAGCATGTGAC
TGTACTGACTACTGTAGGCAGTTGTAACACAGTGGTAAACATTTGTGTATCGAAACATAGAAAAGGCGTAGCAAAAATACAGTATTGTGG
AACCACTGCCATATACGTGGTCCATCCTTGACTGAACATCATGCGGCATGTGGCTGTATGTATACACATAGTTTTTGCTGTGAGTTTGCA
TCCATCTCATAGGAAGACATATATCAAAATAAGGACCAGACTGGAGAGTGTGTAAATTACTTTTCAATACTAATGGCTTATTAATTTGAT
ATTGTCAGCAAGTATGTTGCAAAAACAAATTCCACCAGAATGTGAGTTCCATGAGAGCAGGAACTGGGTTGTTCACCTTGTTGGCACTTG
GAGTAGAGCCACTGAGCTTCGTGCTGCATAAAATTGCTTGGAAGAAAGAAGGGAGGGCATTCCAGGTAACTGAAGCATTGCTATGCAAAG
TAAGCATTTGCCCTCTGAAATATTTTAACAATGTTTATAGAAACCTTTCTCAATTGTATTAAACTTTGTAAATTGTAAAAATTATTCTGT
TATACCTTTTCTATTTACTAGGCACAGGCAGCCATAGGTGCTAGGTATGTTTTGAAAACATATTGAACCTACAGTGTACATATCATTCCA
TGCCATTAAATATTCTTATTTAATCATAGATGTGTTCAGGTGTGTTTGGTTTCCTATTTGTGGATGTACTAGATTGTTTTCTTTTTTTAA
CAAAACCTGTGAACTTGCTTTAAGTATTATCATTTGGTGACATGCCCGCCATTTCAGAAATAAATGTTTGAGCAAAGAGGAAAGCCACCG
GGTCTGATTCAGCTCTCTGGAGGCTCCAGAGCTTACCTCGCTGATGGGAAAAAGAGCATCGATTTAATTGCCCTTGGTACCGACTTCTAG
TATCTAGTATTTTGCCAGACTCAGGTATTTCTTAAAGCCATTATTCAGAGTCTTCAGCAAGGACATTGTATTTTACTTGTGTCTCCTTAG
TTTTACCTAGTTTATTTCATGGTTTTAAAGTATTGTACATTTTTATAATCCTTTAACAAGACAAAAGGTTGAGATGTTGGACATTTAAAT
GCCAAAGGTGTTTTATTATGAGACTTAGCATTTCATATTTGGGGATGGTACCTTATCGAAAATCAGATAAACTTTGGTTGGATGGGTATT
TGGAGGAATCTTTTAAGTCTTTTCTTAAGCAAAGTTTGGACACTCTAAAATAAGGTTGCCAACTGGCATGTAGAGAGAAAAGGATGTGTC
ATACATTTAGACCAGGTGGCCTGTCCTGTAAATTTTTTTGAGGGGAGGGGTGGGCTTGTTTTTTTCTGTGTTTCGGTTTTTTCCAATTTT

>62738_62738_1_PARG-BMS1_PARG_chr10_51093249_ENST00000402038_BMS1_chr10_43287075_ENST00000374518_length(amino acids)=1192AA_BP=122
MRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWD
KVLEEAEAQHLYQSILPDMVKIALCLPNICTQGAKLFYLSGMVHGEYQNQEIHNLGRFITVMKFRPLTWQTSHPYILADRMEDLTNPEDI
RTNIKCDRKVSLYGYLRGAHLKNKSQIHMPGVGDFAVSDISFLPDPCALPEQQKKRCLNEKEKLVYAPLSGVGGVLYDKDAVYVDLGGSH
VFQDEVGPTHELVQSLISTHSTIDAKMASSRVTLFSDSKPLGSEDIDNQGLMMPKEEKQMDLNTGRMRRKAIFGDEDESGDSDDEEDDEM
SEDDGLENGSSDEEAEEEENAEMTDQYMAVKGIKRRKLELEEDSEMDLPAFADSDDDLERSSAEEGEAEEADESSEEEDCTAGEKGISGS
KAAGEGSKAGLSPANCQSDRVNLEKSLLMKKAALPTFDSGHCTAEEVFASEDESEESSSLSAEEEDSENEEAIRKKLSKPSQVSSGQKLG
PQNFIDETSDIENLLKEEEDYKEENNDSKETSGALKWKEDLSRKAAEAFLRQQQAAPNLRKLIYGTVTEDNEEEDDDTLEELGGLFRVNQ
PDRECKHKADSLDCSRFLVEAPHDWDLEEVMNSIRDCFVTGKWEDDKDAAKVLAEDEELYGDFEDLETGDVHKGKSGPNTQNEDIEKEVK
EEIDPDEEESAKKKHLDKKRKLKEMFDAEYDEGESTYFDDLKGEMQKQAQLNRAEFEDQDDEARVQYEGFRPGMYVRIEIENVPCEFVQN
FDPHYPIILGGLGNSEGNVGYVQMRLKKHRWYKKILKSRDPIIFSVGWRRFQTIPLYYIEDHNGRQRLLKYTPQHMHCGAAFWGPITPQG
TGFLAIQSVSGIMPDFRIAATGVVLDLDKSIKIVKKLKLTGFPYKIFKNTSFIKGMFNSALEVAKFEGAVIRTVSGIRGQIKKALRAPEG
AFRASFEDKLLMSDIVFMRTWYPVSIPAFYNPVTSLLKPVGEKDTWSGMRTTGQLRLAHGVRLKANKDSLYKPILRQKKHFNSLHIPKAL
QKALPFKNKPKTQAKAGKVPKDRRRPAVIREPHERKILALLDALSTVHSQKMKKAKEQRHLHNKEHFRAKQKEEEEKLKRQKDLRKKLFR

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Fusion Gene PPI Analysis for PARG-BMS1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PARG-BMS1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PARG-BMS1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source