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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PARN-SMG1 (FusionGDB2 ID:62793)

Fusion Gene Summary for PARN-SMG1

Fusion gene summary

Fusion gene information	Fusion gene name: PARN-SMG1
	Fusion gene ID: 62793
		Hgene	Tgene
	Gene symbol	PARN	SMG1
	Gene ID	5073	23049
	Gene name	poly(A)-specific ribonuclease	SMG1 nonsense mediated mRNA decay associated PI3K related kinase
	Synonyms	DAN\|DKCB6\|PFBMFT4	61E3.4\|ATX\|LIP
	Cytomap	16p13.12	16p12.3
	Type of gene	protein-coding	protein-coding
	Description	poly(A)-specific ribonuclease PARNdeadenylating nucleasedeadenylation nucleasepolyadenylate-specific ribonuclease	serine/threonine-protein kinase SMG1PI-3-kinase-related kinase SMG-1SMG1 phosphatidylinositol 3-kinase-related kinaselambda-interacting proteinlambda/iota protein kinase C-interacting proteinsmg-1 homolog, phosphatidylinositol 3-kinase-related kinase
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000341484, ENST00000420015, ENST00000437198, ENST00000539279, ENST00000566021,	ENST00000565224, ENST00000567737, ENST00000389467, ENST00000446231,
Fusion gene scores	* DoF score	15 X 15 X 6=1350	17 X 19 X 7=2261
	# samples	16	18
	** MAII score	log2(16/1350*10)=-3.07681559705083 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/2261*10)=-3.65089218042185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PARN [Title/Abstract] AND SMG1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PARN(14645878)-SMG1(18849788), # samples:1
Anticipated loss of major functional domain due to fusion event.	PARN-SMG1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PARN-SMG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PARN-SMG1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PARN-SMG1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PARN-SMG1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PARN	GO:0000495	box H/ACA snoRNA 3'-end processing	22442037
Hgene	PARN	GO:0010587	miRNA catabolic process	25049417
Hgene	PARN	GO:0071051	polyadenylation-dependent snoRNA 3'-end processing	22442037
Tgene	SMG1	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	11544179
Tgene	SMG1	GO:0018105	peptidyl-serine phosphorylation	11544179\|15175154
Tgene	SMG1	GO:0046777	protein autophosphorylation	11331269\|11544179
Tgene	SMG1	GO:0046854	phosphatidylinositol phosphorylation	11331269
Tgene	SMG1	GO:2001020	regulation of response to DNA damage stimulus	15175154

Fusion gene breakpoints across PARN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SMG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-S3-AA0Z-01A	PARN	chr16	14645878	-	SMG1	chr16	18849788	-

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Fusion Gene ORF analysis for PARN-SMG1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000341484	ENST00000565224	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
5CDS-intron	ENST00000341484	ENST00000567737	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
5CDS-intron	ENST00000420015	ENST00000565224	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
5CDS-intron	ENST00000420015	ENST00000567737	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
5CDS-intron	ENST00000437198	ENST00000565224	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
5CDS-intron	ENST00000437198	ENST00000567737	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
5CDS-intron	ENST00000539279	ENST00000565224	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
5CDS-intron	ENST00000539279	ENST00000567737	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
Frame-shift	ENST00000341484	ENST00000389467	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
Frame-shift	ENST00000341484	ENST00000446231	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
In-frame	ENST00000420015	ENST00000389467	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
In-frame	ENST00000420015	ENST00000446231	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
In-frame	ENST00000437198	ENST00000389467	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
In-frame	ENST00000437198	ENST00000446231	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
In-frame	ENST00000539279	ENST00000389467	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
In-frame	ENST00000539279	ENST00000446231	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
intron-3CDS	ENST00000566021	ENST00000389467	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
intron-3CDS	ENST00000566021	ENST00000446231	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
intron-intron	ENST00000566021	ENST00000565224	PARN	chr16	14645878	-	SMG1	chr16	18849788	-
intron-intron	ENST00000566021	ENST00000567737	PARN	chr16	14645878	-	SMG1	chr16	18849788	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000437198	PARN	chr16	14645878	-	ENST00000389467	SMG1	chr16	18849788	-	10243	1622	91	5526	1811
ENST00000437198	PARN	chr16	14645878	-	ENST00000446231	SMG1	chr16	18849788	-	10240	1622	91	5523	1810
ENST00000420015	PARN	chr16	14645878	-	ENST00000389467	SMG1	chr16	18849788	-	10097	1476	83	5380	1765
ENST00000420015	PARN	chr16	14645878	-	ENST00000446231	SMG1	chr16	18849788	-	10094	1476	83	5377	1764
ENST00000539279	PARN	chr16	14645878	-	ENST00000389467	SMG1	chr16	18849788	-	9689	1068	62	4972	1636
ENST00000539279	PARN	chr16	14645878	-	ENST00000446231	SMG1	chr16	18849788	-	9686	1068	62	4969	1635

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000437198	ENST00000389467	PARN	chr16	14645878	-	SMG1	chr16	18849788	-	0.000211314	0.9997887
ENST00000437198	ENST00000446231	PARN	chr16	14645878	-	SMG1	chr16	18849788	-	0.000356018	0.9996439
ENST00000420015	ENST00000389467	PARN	chr16	14645878	-	SMG1	chr16	18849788	-	0.000216181	0.9997838
ENST00000420015	ENST00000446231	PARN	chr16	14645878	-	SMG1	chr16	18849788	-	0.00036279	0.99963725
ENST00000539279	ENST00000389467	PARN	chr16	14645878	-	SMG1	chr16	18849788	-	0.000222053	0.999778
ENST00000539279	ENST00000446231	PARN	chr16	14645878	-	SMG1	chr16	18849788	-	0.000369173	0.9996308

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Fusion Genomic Features for PARN-SMG1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PARN-SMG1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:14645878/chr16:18849788)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PARN

chr16:14645878

chr16:18849788

ENST00000341484

178_245

432

579.0

Domain

R3H

Hgene

PARN

chr16:14645878

chr16:18849788

ENST00000420015

178_245

447

594.0

Domain

R3H

Hgene

PARN

chr16:14645878

chr16:18849788

ENST00000437198

178_245

493

640.0

Domain

R3H

Tgene

SMG1

chr16:14645878

chr16:18849788

ENST00000446231

3629_3661

2361

3662.0

Domain

FATC

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SMG1

chr16:14645878

chr16:18849788

ENST00000446231

1283_1866

2361

3662.0

Domain

FAT

Tgene

SMG1

chr16:14645878

chr16:18849788

ENST00000446231

2150_2478

2361

3662.0

Domain

PI3K/PI4K

Tgene

SMG1

chr16:14645878

chr16:18849788

ENST00000446231

1817_1852

2361

3662.0

Repeat

Note=HEAT

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Fusion Gene Sequence for PARN-SMG1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>62793_62793_1_PARN-SMG1_PARN_chr16_14645878_ENST00000420015_SMG1_chr16_18849788_ENST00000389467_length(transcript)=10097nt_BP=1476nt
TTTCCGGAAGTCGCGGCCGGCGTCACCGCTGCGGCTGCCTCAGCTACTGCCGCAGTCGCCGCGGAATTCGGCGAGTAGAACCGCTGAGGC
GGGCGCGGGCCCGGGTGGGGCCAAGGTTCCGGCCACTCTGCAGAATGGAGATAATCAGGAGCAATTTTAAGAGTAATCTTCACAAAGTGT
ACCAGGCCATAGAGGAGGCCGACTTCTTCGCCATCGATGGGGAGTTTTCAGGAATCAGTGATGGACCTTCAGTCTCTGCATTAACAAATG
GTTTTGACACTCCAGAAGAGAGATCCTCACCAGATGTCAAATTTGTTTGTCAGAGCTCCAGCATTGACTTTCTAGCAAGCCAGGGATTTG
ATTTTAATAAAGTTTTTCGAAATGGAATTCCATATTTAAATCAGGAAGAAGAAAGACAGTTAAGAGAGCAGTATGATGAAAAACGTTCAC
AGGCGAATGGTGCAGGAGCTCTGTCCTATGTATCTCCTAACACTTCAAAATGTCCTGTCACGATTCCTGAGGATCAAAAGAAGTTTATTG
ACCAAGTGGTAGAGAAAATAGAGGATTTATTACAAAGTGAAGAAAACAAGAACTTGGATTTAGAGCCATGTACCGGGTTCCAAAGAAAAC
TAATTTATCAGACTTTGAGCTGGAAGTATCCGAAAGGCATTCATGTTGAGACTTTAGAAACTGAAAAGAAGGAGCGATATATAGTTATCA
GCAAAGTAGATGAAGAAGAACGCAAAAGAAGAGAGCAGCAGAAACATGCCAAAGAACAGGAGGAGCTGAATGATGCTGTGGGATTTTCTA
GAGTCATTCACGCCATTGCTAATTCGGGAAAACTTGTTATTGGACACAATATGCTCTTGGACGTCATGCACACAGTTCATCAGTTCTACT
GCCCTCTGCCTGCGGACTTAAGTGAGTTTAAAGAGATGACAACATGTGTTTTCCCCAGACTCTTGGATACTAAATTGATGGCCAGCACAC
AACCTTTTAAGGATATCATTAACAACACATCCCTTGCGGAATTGGAAAAGCGGTTAAAAGAGACACCTTTCAACCCTCCTAAAGTTGAAA
GTGCCGAAGGTTTTCCAAGTTATGACACAGCCTCTGAACAACTCCACGAGGCAGGCTACGATGCCTACATCACAGGGCTGTGCTTCATCT
CCATGGCCAATTACCTAGGTTCTTTTCTCAGCCCTCCAAAAATTCATGTGTCTGCCAGATCAAAACTCATTGAACCTTTTTTTAACAAGT
TATTTCTTATGAGGGTCATGGATATCCCCTATCTAAACTTGGAAGGACCAGACTTGCAGCCTAAACGTGATCATGTTCTCCATGTGACAT
TCCCCAAAGAATGGAAAACCAGCGACCTTTACCAGCTTTTCAGTGCCTTTGGTAACATTCAGATATCCTGGATTGATGACACATCAGCAT
TTGTTTCCCTTAGCCAGCCCGAGCAAGTAAAGATTGGTAAAAGCCTTAGAGTTCCTGAGAAAGTACCTTTTCGAATGACACAAAACATTG
AAACAGCACTGGGTGTAACTGGAGTAGAAGGTGTATTTAGGCTTTCATGTGAGCAGGTTTTACACATTATGCGGCGTGGCAGAGAGACCC
TGCTGACGCTGCTGGAGGCCTTTGTGTACGACCCTCTGGTGGACTGGACAGCAGGAGGCGAGGCTGGGTTTGCTGGTGCTGTCTATGGTG
GAGGTGGCCAGCAGGCCGAGAGCAAGCAGAGCAAGAGAGAGATGGAGCGAGAGATCACCCGCAGCCTGTTTTCTTCTAGAGTAGCTGAGA
TTAAGGTGAACTGGTTTAAGAATAGAGATGAGATGCTGGTTGTGCTTCCCAAGTTGGACGGTAGCTTAGATGAATACCTAAGCTTGCAAG
AGCAACTGACAGATGTGGAAAAACTGCAGGGCAAACTACTGGAGGAAATAGAGTTTCTAGAAGGAGCTGAAGGGGTGGATCATCCTTCTC
ATACTCTGCAACACAGGTATTCTGAGCACACCCAACTACAGACTCAGCAAAGAGCTGTTCAGGAAGCAATCCAGGTGAAGCTGAATGAAT
TTGAACAATGGATAACACATTATCAGGCTGCATTCAATAATTTAGAAGCAACACAGCTTGCAAGCTTGCTTCAAGAGATAAGCACACAAA
TGGACCTTGGTCCTCCAAGTTACGTGCCAGCAACAGCCTTTCTGCAGAATGCTGGTCAGGCCCACTTGATTAGCCAGTGCGAGCAGCTGG
AGGGGGAGGTTGGTGCTCTCCTGCAGCAGAGGCGCTCCGTGCTCCGTGGCTGTCTGGAGCAACTGCATCACTATGCAACCGTGGCCCTGC
AGTATCCGAAGGCCATATTTCAGAAACATCGAATTGAACAGTGGAAGACCTGGATGGAAGAGCTCATCTGTAACACCACAGTAGAGCGTT
GTCAAGAGCTCTATAGGAAATATGAAATGCAATATGCTCCCCAGCCACCCCCAACAGTGTGTCAGTTCATCACTGCCACTGAAATGACCC
TGCAGCGATACGCAGCAGACATCAACAGCAGACTTATTAGACAAGTGGAACGCTTGAAACAGGAAGCTGTCACTGTGCCAGTTTGTGAAG
ATCAGTTGAAAGAAATTGAACGTTGCATTAAAGTTTTCCTTCATGAGAATGGAGAAGAAGGATCTTTGAGTCTAGCAAGTGTTATTATTT
CTGCCCTTTGTACCCTTACAAGGCGTAACCTGATGATGGAAGGTGCAGCGTCAAGTGCTGGAGAACAGCTGGTTGATCTGACTTCTCGGG
ATGGAGCCTGGTTCTTGGAGGAACTCTGCAGTATGAGCGGAAACGTCACCTGCTTGGTTCAGTTACTGAAGCAGTGCCACCTGGTGCCAC
AGGACTTAGATATCCCGAACCCCATGGAAGCGTCTGAGACAGTTCACTTAGCCAATGGAGTGTATACCTCACTTCAGGAATTGAATTCGA
ATTTCCGGCAAATCATATTTCCAGAAGCACTTCGATGTTTAATGAAAGGGGAATACACGTTAGAAAGTATGCTGCATGAACTGGACGGTC
TTATTGAGCAGACCACCGATGGCGTTCCCCTGCAGACTCTAGTGGAATCTCTTCAGGCCTACTTAAGAAACGCAGCTATGGGACTGGAAG
AAGAAACACATGCTCATTACATCGATGTTGCCAGACTACTACATGCTCAGTACGGTGAATTAATCCAACCGAGAAATGGTTCAGTTGATG
AAACACCCAAAATGTCAGCTGGCCAGATGCTTTTGGTAGCATTCGATGGCATGTTTGCTCAAGTTGAAACTGCTTTCAGCTTATTAGTTG
AAAAGTTGAACAAGATGGAAATTCCCATAGCTTGGCGAAAGATTGACATCATAAGGGAAGCCAGGAGTACTCAAGTTAATTTTTTTGATG
ATGATAATCACCGGCAGGTGCTAGAAGAGATTTTCTTTCTAAAAAGACTACAGACTATTAAGGAGTTCTTCAGGCTCTGTGGTACCTTTT
CTAAAACATTGTCAGGATCAAGTTCACTTGAAGATCAGAATACTGTGAATGGGCCTGTACAGATTGTCAATGTGAAAACCCTTTTTAGAA
ACTCTTGTTTCAGTGAAGACCAAATGGCCAAACCTATCAAGGCATTCACAGCTGACTTTGTGAGGCAGCTCTTGATAGGGCTACCCAACC
AAGCCCTCGGACTCACACTGTGCAGTTTTATCAGTGCTCTGGGTGTAGACATCATTGCTCAAGTAGAGGCAAAGGACTTTGGTGCCGAAA
GCAAAGTTTCTGTTGATGATCTCTGTAAGAAAGCGGTGGAACATAACATCCAGATAGGGAAGTTCTCTCAGCTGGTTATGAACAGGGCAA
CTGTGTTAGCAAGTTCTTACGACACTGCCTGGAAGAAGCATGACTTGGTGCGAAGGCTAGAAACCAGTATTTCTTCTTGTAAGACAAGCC
TGCAGCGGGTTCAGCTGCATATTGCCATGTTTCAGCAGTGGCAACATGAAGATCTACTTATCAATAGACCACAAGCCATGTCAGTCACAC
CTCCCCCACGGTCTGCTATCCTAACCAGCATGAAAAAGAAGCTGCATACCCTGAGCCAGATTGAAACTTCTATTGCAACAGTTCAGGAGA
AGCTAGCTGCACTTGAATCAAGTATTGAACAGCGACTCAAGTGGGCAGGTGGTGCCAACCCTGCATTGGCCCCTGTACTACAAGATTTTG
AAGCAACGATAGCTGAAAGAAGAAATCTTGTCCTTAAAGAGAGCCAAAGAGCAAGTCAGGTCACATTTCTCTGCAGCAATATCATTCATT
TTGAAAGTTTACGAACAAGAACTGCAGAAGCCTTAAACCTGGATGCGGCGTTATTTGAACTAATCAAGCGATGTCAGCAGATGTGTTCGT
TTGCATCACAGTTTAACAGTTCAGTGTCTGAGTTAGAGCTTCGTTTATTACAGAGAGTGGACACTGGTCTTGAACATCCTATTGGCAGCT
CTGAATGGCTTTTGTCAGCACACAAACAGTTGACCCAGGATATGTCTACTCAGAGGGCAATTCAGACAGAGAAAGAGCAGCAGATAGAAA
CGGTCTGTGAAACAATTCAGAATCTGGTTGATAATATAAAGACTGTGCTCACTGGTCATAACCGACAGCTTGGAGATGTCAAACATCTCT
TGAAAGCTATGGCTAAGGATGAAGAAGCTGCTCTGGCAGATGGTGAAGATGTTCCCTATGAGAACAGTGTTAGGCAGTTTTTGGGTGAAT
ATAAATCATGGCAAGACAACATTCAAACAGTTCTATTTACATTAGTCCAGGCTATGGGTCAGGTTCGAAGTCAAGAACACGTTGAAATGC
TCCAGGAAATCACTCCCACCTTGAAAGAACTGAAAACACAAAGTCAGAGTATCTATAATAATTTAGTGAGTTTTGCATCACCCTTAGTCA
CCGATGCAACAAATGAATGTTCGAGTCCAACGTCATCTGCTACTTATCAGCCATCCTTCGCTGCAGCAGTCCGGAGTAACACTGGCCAGA
AGACTCAGCCTGATGTCATGTCACAGAATGCTAGAAAGCTGATCCAAAAAAATCTTGCTACATCAGCTGATACTCCACCAAGCACCGTTC
CAGGAACTGGCAAGAGTGTTGCTTGTAGTCCTAAAAAGGCAGTCAGAGACCCTAAAACTGGGAAAGCGGTGCAAGAGAGAAACTCCTATG
CAGTGAGTGTGTGGAAGAGAGTGAAAGCCAAGTTAGAGGGCCGAGATGTTGATCCGAATAGGAGGATGTCAGTTGCTGAACAGGTTGACT
ATGTCATTAAGGAAGCAACTAATCTAGATAACTTGGCTCAGCTGTATGAAGGTTGGACAGCCTGGGTGTGAATGGCAAGACAGTAGATGA
GTCTGGTTAAGCGAGGTCAGACATCCACCAGAATCAACTCAGCCTCAGGCATCCAAAGCCACACCACAGTCGGTGGTGATGCAACTGGGG
GCTTACTCTGAGGAAACCTAGGAAATCTCGGTGCACTAGGAAGTGAATCCCGCAGGACAGCTGCACTCAGGGATACGCCCAACACCATGG
CCTGCAACCCCAGGGTCAAGGGTGAAGGAAAGCAAGCTCACCGCCTGAACACGGAGATTGTCTTTCTGCCACAGAACAGCAGCAGACGTG
TCGGGAGGTTAGCTGCGGAAAGAAATCGGGATGCCGCGGAGCACAGAGTGATTTGGAACTCCATTCCACCTGACCCTGTGTGTACAATCC
AGGAAAAAAACAAACCCCACTCAGAAACAGAGAAAACTGGGGTCGCGAAGAAATCACAGCCAAGGAAGATTTGATGCATTCAGATTCTCG
TGTAACACTTGTTGCTTGGCAACAGTACTGGTTGGGTTGACCAGTAAGTAGAAAAAGGCTAAAGGCTATGCGATATGAATTTCAGAAATG
GACTGAAAATGGAGAGCTATGTAACAGATACACTACAGTAGAAGAACTTACTTCTGAAATGAAGGGAAAAAAACCACCCCATCGTTCCCT
ACTCCTCCCCACCACTTACCCGTTCCCCCTTTACCTAATCTAGTAGATTAGCCATCTTTCAAATTCACTTTTATTTCAGTCCTTATATTT
CATATACTTCCGTCTCGATGCTGTTAACAACTTCTGATAACATGGAAAATTCAAGGATTGTTTAAAGGTCTGATGATCACACACAAAATG
TAATTCCGGTTATTTAAGTCATTTCTGTGATTCTATCATGTACAGTTTCCAGAATTGTCACTGTGCATTCAAAAGTAATGAATCTAACAG
ACATTTGATTTAATGTACACTCCCTTTTGCTTATAGTGTGCATTTTTTTTGGAGGTCATTCAAATTTTCCCTCTTCTGTGATAGCTGTAG
TTTCTTTCATAGAAAGTAGCTAATCCAGTGTAATCTTTTACCTTTTTAAAAACCAAGATAGAGTATCTATTAGAGTTTTACATTGTTGAT
GATAGATTAACAATAAAGTGATGTTCTGGTGGAGGTAGACTGAAATTTTTTTAATTCATGTTTTTCATTTGATACTTTTAATTTACACTT
AGTAAATTAAAAGTTGTTTAATTTACTTGGCATTTTAGGACATGTACATGAAACAGTGAAAATGAGATCCACCAACATCTTTTATTAAGT
TCAGTTATTAGTCTGTGAAGTGCTTTACTTTTTGCACAATTTTAATAGCTTGCTATTCAGTAATACATTATAGTGAATTCATGATCAAGG
TTTCCTTAAATTTAGCATTGCATTTCAGTACTGACTGTGTAAGCTAAATTGCTGATCCAAAATAAAAACCCAGACTAGAATAGGGTTCTT
AAAATCAAGTATCAATACAAAATAGAACACAATTAAAATCTTAATTGTTGGCTGGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTG
GGAGGCCGAGGCGGGCGGATCATGAGGTTAGGAGAGCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTTTACTAAAAATACAAAAA
AAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAGCT
TGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCTAGACTCTGTGTCAAAAATAAATGACTAGATAAAAAAAAAA
ATTGTTTGAGTACATTTTCCCTGCATTTTAGAGATTAGGACAGTGGTCACTTTCTAGTTGCCGTCTTCACAGACAAACTTGAAAGGTATT
AAGGAAAAAATTCCACATAGCTCTGGGCCTTTTTTGTATTCTGATTGCCACGTTAATCTGTAATCGTTAAGTACCCATGAAAGAATGTGT
TTCAGTATCAGTGCTTTTTTGGTACTTTAACAAGTATTGTAGGCACGGTGGATTTTTTTGAAATACCCATGTGTCCAATAGCAAGTTAAG
GAACCTAGCGCATCAAATTTTGTTTTCTTCATTCATTTGGAACCTTATTTTCGCAAAAAACCTAGCTGGAATAATAATGCCATATTGTAT
TTTGCACACTGCTTTATTTTCTAGAGGCTCTGGGAGCAAATTACATTCATCACATTACCTCTGCTCTCTCAAGATTAAAGTCTTTCAGCA
ACATTCTTTATTGTCATCATAAGGAAAAACTTTTATCGCAATGATAGTCAGTTCACATTAGTTTAGCACTATAGATAGTATTCAGAAATT
GCTTTCTCTTTGGTAAAGAAGATAAATAGGTGAATTTTATTGCCTGTGTTTTCAGGCTTCAGAGGTACCTGGCACCTTACTCAAGCAAAA
ACAAAAAACAGCTTTACTTCAAAAGCATGTGCCTCTGGTAAATTATCCATCACTTTTGTTTTAAAGTGGTCCCTCCAAGAATAATGTGGC
ATACACAGTGGGTTTGGTTGTAAGGCAGATGTAATAGATGACTTCAAAAGCCTGCTCCTTACTGCACTCTGGACAAGGCCCTGGTCTGTA
TAGTTTGGCTTCCTCTGTTAAGTCATTCTACAAGGTGACTTGCCATTTGAACTTTCGTAAGAGACCTCAGCAGTTAGACTGAGAAAAGTT
AGAGTGCTGTAGTTATGAAGTCATACATTTTTGATAAAATACCTGTGGAAAACCAGGGATCCTCTCCTGTTTCTCTCTCTTGCCTCCCCC
TTTCCCTCCATTCCTCTGTCGCCTCCCCCTCTCCTCCACTTTCTTTAAGAATCAGGGGGTACAGAATAACCTACAAACAACCTCTTCAAA
GTACCCTTGGAAATTGAAGTTCAATCTTAAGTTTTTTGCTGTCTTTAATTTACTAGAATTGCCTAATTTTTAGTTGATTTCTCTACAGAG
CTTAGCTTGTGTAGTTATTTCTCTTTTACTGTTGCTTTGGTGTGTCTTGAAGTTTGATTGATTATTTTTGGTCATTGAGTTCTTAGTGTA
GTTTGCTAGATGATTATTAAGATTCTTTTGTGTCTGACACTTGTGGTGAGTTGCTTTTGAAATCTGTTGAGATTTCCATGTGAGAACTGA
TAATCAGGCTCTTGATCTGCTTCCCTAAATTACTTTTTTAGAGCCCAAACCCCAGGTTTAGGGTGAGGGTTTGTAATACAAAGAAACACT
TCCATCACTTCTGCCCTTAACCCTTGCCTCTATTACCTAAGCTTAGTAAGTAGTTTTCTTAATATTGTCCAATGTTTGGTGTTATCTGCA
TTGTTTTTTGTTTTTTTAATTGTGGTTGTTCTGACGTGTGAAATTTAAGGAAAGAGCCATTTTTTAAAAATGCCGAGCAGGGCAATGCAA
GTACAGCCAAATATTAGACTTGATGTGCAATCTTCGGTCCTTTTTAATCTGGGGTATTATAGGCAGTACTTTAAATTGCAAAGTCTTCCG
GGCCTATTTTCCTCTACATTTTTGTAATTAACTCTGGGGGCTTACTTGTTTTGGCAGTACTGAAATCAAAGGAGCTGGTTCTTCTTTTCT
CCCAATTATTTTCATATGAAAGCACCTACAATTAGCCTGTTAGTCCTATTCAGATACATCAAATATCAGTGAATGCTTTACTATTCGCAC
ATTTAAGCATCTTTGTTTTACATAAAATTAGAGTATGAAAACCAGTGTTCAATTTTTTATCTTGTTGAGCTTGTAAAATGCCAGCAATTT
AAAACTAGGACTTTTCCCCCCATAAGCCAAGGAGGTAGAATTACTAATACAAGGGTTAAAGAAGGTAGATTTTGTTTTCAATATTTGGGT
AATATTAGAAAGATTCTTCCCACAGGGAAGAACTAGCAAGTGTCCCAATTTTTTCCAAACGTTGGGGAGGGGAAAATTCACTGTATCATG
AAACCCTAAGGGTTTGTTGCACTTCCTGCTTTTTAGGCCTGGATAACAGTATCACCATCCTTATTTACAGAAGGGTAAAACTGACTCTTA
ATGAGAAAAGCTTTATAAGTTCAAGGGCTGTAAAATATGAACTACTTAGGGTCGTTTGCCTTCCATGGGAACTTGGCTAGACTTAGAAAA
AGCTGTTTGTTGTGCTAATGTAAAAGTGTCATACAATTTAGAAGATTTTTGAAGATGGTAAACTTAGAAGAATTCTATGTTCTGAAATGC
ACACTTTTAGAATGTTTTTCTTTGAAAACAGGCTAATAGTTTTTTCTTTTTTTGACAAAGTTTCAGCTCCTCTTTAAAGTTATTGTGTCA
TTTTTCTGGTTTAAATTTCCCTTATATTTCCACCTGTAATGTCAGTGGCAACAACATCATACTTCACTTACTTGTTAATTTACTTTTTAC
CCTTATTCTAAGAGCAAGTTGAGTTGAACTGAATCTTCCTTGTCTTAGTAACAATGTATAAATAGTGGCTTTTCTGTACAAAAGGTTGTA
ATGCCTCCTGATGGATATAATTTTGTGATTGTATTTAAAAGTTGAATAAATCACACCAGCTTCCTGAAAATGTTCATAATGCATCTTTTG
GAAAACAAATACATGCCTACTTTGTGCATATTTGCATTAACATGGCAAAGATTGTATGAAATACCTGTTTTTCAGAAAATAAAGGTTCAG

>62793_62793_1_PARN-SMG1_PARN_chr16_14645878_ENST00000420015_SMG1_chr16_18849788_ENST00000389467_length(amino acids)=1765AA_BP=464
MRRARARVGPRFRPLCRMEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERSSPDVKFVCQSSSIDFLASQ
GFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQ
RKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQ
FYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLC
FISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDT
SAFVSLSQPEQVKIGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGFAGAV
YGGGGQQAESKQSKREMEREITRSLFSSRVAEIKVNWFKNRDEMLVVLPKLDGSLDEYLSLQEQLTDVEKLQGKLLEEIEFLEGAEGVDH
PSHTLQHRYSEHTQLQTQQRAVQEAIQVKLNEFEQWITHYQAAFNNLEATQLASLLQEISTQMDLGPPSYVPATAFLQNAGQAHLISQCE
QLEGEVGALLQQRRSVLRGCLEQLHHYATVALQYPKAIFQKHRIEQWKTWMEELICNTTVERCQELYRKYEMQYAPQPPPTVCQFITATE
MTLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKVFLHENGEEGSLSLASVIISALCTLTRRNLMMEGAASSAGEQLVDLT
SRDGAWFLEELCSMSGNVTCLVQLLKQCHLVPQDLDIPNPMEASETVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGEYTLESMLHEL
DGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHYIDVARLLHAQYGELIQPRNGSVDETPKMSAGQMLLVAFDGMFAQVETAFSL
LVEKLNKMEIPIAWRKIDIIREARSTQVNFFDDDNHRQVLEEIFFLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQIVNVKTL
FRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFISALGVDIIAQVEAKDFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMN
RATVLASSYDTAWKKHDLVRRLETSISSCKTSLQRVQLHIAMFQQWQHEDLLINRPQAMSVTPPPRSAILTSMKKKLHTLSQIETSIATV
QEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKESQRASQVTFLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQM
CSFASQFNSSVSELELRLLQRVDTGLEHPIGSSEWLLSAHKQLTQDMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVK
HLLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDNIQTVLFTLVQAMGQVRSQEHVEMLQEITPTLKELKTQSQSIYNNLVSFASP
LVTDATNECSSPTSSATYQPSFAAAVRSNTGQKTQPDVMSQNARKLIQKNLATSADTPPSTVPGTGKSVACSPKKAVRDPKTGKAVQERN

--------------------------------------------------------------
>62793_62793_2_PARN-SMG1_PARN_chr16_14645878_ENST00000420015_SMG1_chr16_18849788_ENST00000446231_length(transcript)=10094nt_BP=1476nt
TTTCCGGAAGTCGCGGCCGGCGTCACCGCTGCGGCTGCCTCAGCTACTGCCGCAGTCGCCGCGGAATTCGGCGAGTAGAACCGCTGAGGC
GGGCGCGGGCCCGGGTGGGGCCAAGGTTCCGGCCACTCTGCAGAATGGAGATAATCAGGAGCAATTTTAAGAGTAATCTTCACAAAGTGT
ACCAGGCCATAGAGGAGGCCGACTTCTTCGCCATCGATGGGGAGTTTTCAGGAATCAGTGATGGACCTTCAGTCTCTGCATTAACAAATG
GTTTTGACACTCCAGAAGAGAGATCCTCACCAGATGTCAAATTTGTTTGTCAGAGCTCCAGCATTGACTTTCTAGCAAGCCAGGGATTTG
ATTTTAATAAAGTTTTTCGAAATGGAATTCCATATTTAAATCAGGAAGAAGAAAGACAGTTAAGAGAGCAGTATGATGAAAAACGTTCAC
AGGCGAATGGTGCAGGAGCTCTGTCCTATGTATCTCCTAACACTTCAAAATGTCCTGTCACGATTCCTGAGGATCAAAAGAAGTTTATTG
ACCAAGTGGTAGAGAAAATAGAGGATTTATTACAAAGTGAAGAAAACAAGAACTTGGATTTAGAGCCATGTACCGGGTTCCAAAGAAAAC
TAATTTATCAGACTTTGAGCTGGAAGTATCCGAAAGGCATTCATGTTGAGACTTTAGAAACTGAAAAGAAGGAGCGATATATAGTTATCA
GCAAAGTAGATGAAGAAGAACGCAAAAGAAGAGAGCAGCAGAAACATGCCAAAGAACAGGAGGAGCTGAATGATGCTGTGGGATTTTCTA
GAGTCATTCACGCCATTGCTAATTCGGGAAAACTTGTTATTGGACACAATATGCTCTTGGACGTCATGCACACAGTTCATCAGTTCTACT
GCCCTCTGCCTGCGGACTTAAGTGAGTTTAAAGAGATGACAACATGTGTTTTCCCCAGACTCTTGGATACTAAATTGATGGCCAGCACAC
AACCTTTTAAGGATATCATTAACAACACATCCCTTGCGGAATTGGAAAAGCGGTTAAAAGAGACACCTTTCAACCCTCCTAAAGTTGAAA
GTGCCGAAGGTTTTCCAAGTTATGACACAGCCTCTGAACAACTCCACGAGGCAGGCTACGATGCCTACATCACAGGGCTGTGCTTCATCT
CCATGGCCAATTACCTAGGTTCTTTTCTCAGCCCTCCAAAAATTCATGTGTCTGCCAGATCAAAACTCATTGAACCTTTTTTTAACAAGT
TATTTCTTATGAGGGTCATGGATATCCCCTATCTAAACTTGGAAGGACCAGACTTGCAGCCTAAACGTGATCATGTTCTCCATGTGACAT
TCCCCAAAGAATGGAAAACCAGCGACCTTTACCAGCTTTTCAGTGCCTTTGGTAACATTCAGATATCCTGGATTGATGACACATCAGCAT
TTGTTTCCCTTAGCCAGCCCGAGCAAGTAAAGATTGGTAAAAGCCTTAGAGTTCCTGAGAAAGTACCTTTTCGAATGACACAAAACATTG
AAACAGCACTGGGTGTAACTGGAGTAGAAGGTGTATTTAGGCTTTCATGTGAGCAGGTTTTACACATTATGCGGCGTGGCAGAGAGACCC
TGCTGACGCTGCTGGAGGCCTTTGTGTACGACCCTCTGGTGGACTGGACAGCAGGAGGCGAGGCTGGGTTTGCTGGTGCTGTCTATGGTG
GAGGTGGCCAGCAGGCCGAGAGCAAGCAGAGCAAGAGAGAGATGGAGCGAGAGATCACCCGCAGCCTGTTTTCTTCTAGAGTAGCTGAGA
TTAAGGTGAACTGGTTTAAGAATAGAGATGAGATGCTGGTTGTGCTTCCCAAGTTGGACGGTAGCTTAGATGAATACCTAAGCTTGCAAG
AGCAACTGACAGATGTGGAAAAACTGCAGGGCAAACTACTGGAGGAAATAGAGTTTCTAGAAGGAGCTGAAGGGGTGGATCATCCTTCTC
ATACTCTGCAACACAGGTATTCTGAGCACACCCAACTACAGACTCAGCAAAGAGCTGTTCAGGAAGCAATCCAGGTGAAGCTGAATGAAT
TTGAACAATGGATAACACATTATCAGGCTGCATTCAATAATTTAGAAGCAACACAGCTTGCAAGCTTGCTTCAAGAGATAAGCACACAAA
TGGACCTTGGTCCTCCAAGTTACGTGCCAGCAACAGCCTTTCTGCAGAATGCTGGTCAGGCCCACTTGATTAGCCAGTGCGAGCAGCTGG
AGGGGGAGGTTGGTGCTCTCCTGCAGCAGAGGCGCTCCGTGCTCCGTGGCTGTCTGGAGCAACTGCATCACTATGCAACCGTGGCCCTGC
AGTATCCGAAGGCCATATTTCAGAAACATCGAATTGAACAGTGGAAGACCTGGATGGAAGAGCTCATCTGTAACACCACAGTAGAGCGTT
GTCAAGAGCTCTATAGGAAATATGAAATGCAATATGCTCCCCAGCCACCCCCAACAGTGTGTCAGTTCATCACTGCCACTGAAATGACCC
TGCAGCGATACGCAGCAGACATCAACAGCAGACTTATTAGACAAGTGGAACGCTTGAAACAGGAAGCTGTCACTGTGCCAGTTTGTGAAG
ATCAGTTGAAAGAAATTGAACGTTGCATTAAAGTTTTCCTTCATGAGAATGGAGAAGAAGGATCTTTGAGTCTAGCAAGTGTTATTATTT
CTGCCCTTTGTACCCTTACAAGGCGTAACCTGATGATGGAAGGTGCAGCGTCAAGTGCTGGAGAACAGCTGGTTGATCTGACTTCTCGGG
ATGGAGCCTGGTTCTTGGAGGAACTCTGCAGTATGAGCGGAAACGTCACCTGCTTGGTTCAGTTACTGAAGCAGTGCCACCTGGTGCCAC
AGGACTTAGATATCCCGAACCCCATGGAAGCGTCTGAGACAGTTCACTTAGCCAATGGAGTGTATACCTCACTTCAGGAATTGAATTCGA
ATTTCCGGCAAATCATATTTCCAGAAGCACTTCGATGTTTAATGAAAGGGGAATACACGTTAGAAAGTATGCTGCATGAACTGGACGGTC
TTATTGAGCAGACCACCGATGGCGTTCCCCTGCAGACTCTAGTGGAATCTCTTCAGGCCTACTTAAGAAACGCAGCTATGGGACTGGAAG
AAGAAACACATGCTCATTACATCGATGTTGCCAGACTACTACATGCTCAGTACGGTGAATTAATCCAACCGAGAAATGGTTCAGTTGATG
AAACACCCAAAATGTCAGCTGGCCAGATGCTTTTGGTAGCATTCGATGGCATGTTTGCTCAAGTTGAAACTGCTTTCAGCTTATTAGTTG
AAAAGTTGAACAAGATGGAAATTCCCATAGCTTGGCGAAAGATTGACATCATAAGGGAAGCCAGGAGTACTCAAGTTAATTTTTTTGATG
ATGATAATCACCGGCAGGTGCTAGAAGAGATTTTCTTTCTAAAAAGACTACAGACTATTAAGGAGTTCTTCAGGCTCTGTGGTACCTTTT
CTAAAACATTGTCAGGATCAAGTTCACTTGAAGATCAGAATACTGTGAATGGGCCTGTACAGATTGTCAATGTGAAAACCCTTTTTAGAA
ACTCTTGTTTCAGTGAAGACCAAATGGCCAAACCTATCAAGGCATTCACAGCTGACTTTGTGAGGCAGCTCTTGATAGGGCTACCCAACC
AAGCCCTCGGACTCACACTGTGCAGTTTTATCAGTGCTCTGGGTGTAGACATCATTGCTCAAGTAGAGGCAAAGGACTTTGGTGCCGAAA
GCAAAGTTTCTGTTGATGATCTCTGTAAGAAAGCGGTGGAACATAACATCCAGATAGGGAAGTTCTCTCAGCTGGTTATGAACAGGGCAA
CTGTGTTAGCAAGTTCTTACGACACTGCCTGGAAGAAGCATGACTTGGTGCGAAGGCTAGAAACCAGTATTTCTTCTTGTAAGACAAGCC
TGCAGCGGGTTCAGCTGCATATTGCCATGTTTCAGTGGCAACATGAAGATCTACTTATCAATAGACCACAAGCCATGTCAGTCACACCTC
CCCCACGGTCTGCTATCCTAACCAGCATGAAAAAGAAGCTGCATACCCTGAGCCAGATTGAAACTTCTATTGCAACAGTTCAGGAGAAGC
TAGCTGCACTTGAATCAAGTATTGAACAGCGACTCAAGTGGGCAGGTGGTGCCAACCCTGCATTGGCCCCTGTACTACAAGATTTTGAAG
CAACGATAGCTGAAAGAAGAAATCTTGTCCTTAAAGAGAGCCAAAGAGCAAGTCAGGTCACATTTCTCTGCAGCAATATCATTCATTTTG
AAAGTTTACGAACAAGAACTGCAGAAGCCTTAAACCTGGATGCGGCGTTATTTGAACTAATCAAGCGATGTCAGCAGATGTGTTCGTTTG
CATCACAGTTTAACAGTTCAGTGTCTGAGTTAGAGCTTCGTTTATTACAGAGAGTGGACACTGGTCTTGAACATCCTATTGGCAGCTCTG
AATGGCTTTTGTCAGCACACAAACAGTTGACCCAGGATATGTCTACTCAGAGGGCAATTCAGACAGAGAAAGAGCAGCAGATAGAAACGG
TCTGTGAAACAATTCAGAATCTGGTTGATAATATAAAGACTGTGCTCACTGGTCATAACCGACAGCTTGGAGATGTCAAACATCTCTTGA
AAGCTATGGCTAAGGATGAAGAAGCTGCTCTGGCAGATGGTGAAGATGTTCCCTATGAGAACAGTGTTAGGCAGTTTTTGGGTGAATATA
AATCATGGCAAGACAACATTCAAACAGTTCTATTTACATTAGTCCAGGCTATGGGTCAGGTTCGAAGTCAAGAACACGTTGAAATGCTCC
AGGAAATCACTCCCACCTTGAAAGAACTGAAAACACAAAGTCAGAGTATCTATAATAATTTAGTGAGTTTTGCATCACCCTTAGTCACCG
ATGCAACAAATGAATGTTCGAGTCCAACGTCATCTGCTACTTATCAGCCATCCTTCGCTGCAGCAGTCCGGAGTAACACTGGCCAGAAGA
CTCAGCCTGATGTCATGTCACAGAATGCTAGAAAGCTGATCCAAAAAAATCTTGCTACATCAGCTGATACTCCACCAAGCACCGTTCCAG
GAACTGGCAAGAGTGTTGCTTGTAGTCCTAAAAAGGCAGTCAGAGACCCTAAAACTGGGAAAGCGGTGCAAGAGAGAAACTCCTATGCAG
TGAGTGTGTGGAAGAGAGTGAAAGCCAAGTTAGAGGGCCGAGATGTTGATCCGAATAGGAGGATGTCAGTTGCTGAACAGGTTGACTATG
TCATTAAGGAAGCAACTAATCTAGATAACTTGGCTCAGCTGTATGAAGGTTGGACAGCCTGGGTGTGAATGGCAAGACAGTAGATGAGTC
TGGTTAAGCGAGGTCAGACATCCACCAGAATCAACTCAGCCTCAGGCATCCAAAGCCACACCACAGTCGGTGGTGATGCAACTGGGGGCT
TACTCTGAGGAAACCTAGGAAATCTCGGTGCACTAGGAAGTGAATCCCGCAGGACAGCTGCACTCAGGGATACGCCCAACACCATGGCCT
GCAACCCCAGGGTCAAGGGTGAAGGAAAGCAAGCTCACCGCCTGAACACGGAGATTGTCTTTCTGCCACAGAACAGCAGCAGACGTGTCG
GGAGGTTAGCTGCGGAAAGAAATCGGGATGCCGCGGAGCACAGAGTGATTTGGAACTCCATTCCACCTGACCCTGTGTGTACAATCCAGG
AAAAAAACAAACCCCACTCAGAAACAGAGAAAACTGGGGTCGCGAAGAAATCACAGCCAAGGAAGATTTGATGCATTCAGATTCTCGTGT
AACACTTGTTGCTTGGCAACAGTACTGGTTGGGTTGACCAGTAAGTAGAAAAAGGCTAAAGGCTATGCGATATGAATTTCAGAAATGGAC
TGAAAATGGAGAGCTATGTAACAGATACACTACAGTAGAAGAACTTACTTCTGAAATGAAGGGAAAAAAACCACCCCATCGTTCCCTACT
CCTCCCCACCACTTACCCGTTCCCCCTTTACCTAATCTAGTAGATTAGCCATCTTTCAAATTCACTTTTATTTCAGTCCTTATATTTCAT
ATACTTCCGTCTCGATGCTGTTAACAACTTCTGATAACATGGAAAATTCAAGGATTGTTTAAAGGTCTGATGATCACACACAAAATGTAA
TTCCGGTTATTTAAGTCATTTCTGTGATTCTATCATGTACAGTTTCCAGAATTGTCACTGTGCATTCAAAAGTAATGAATCTAACAGACA
TTTGATTTAATGTACACTCCCTTTTGCTTATAGTGTGCATTTTTTTTGGAGGTCATTCAAATTTTCCCTCTTCTGTGATAGCTGTAGTTT
CTTTCATAGAAAGTAGCTAATCCAGTGTAATCTTTTACCTTTTTAAAAACCAAGATAGAGTATCTATTAGAGTTTTACATTGTTGATGAT
AGATTAACAATAAAGTGATGTTCTGGTGGAGGTAGACTGAAATTTTTTTAATTCATGTTTTTCATTTGATACTTTTAATTTACACTTAGT
AAATTAAAAGTTGTTTAATTTACTTGGCATTTTAGGACATGTACATGAAACAGTGAAAATGAGATCCACCAACATCTTTTATTAAGTTCA
GTTATTAGTCTGTGAAGTGCTTTACTTTTTGCACAATTTTAATAGCTTGCTATTCAGTAATACATTATAGTGAATTCATGATCAAGGTTT
CCTTAAATTTAGCATTGCATTTCAGTACTGACTGTGTAAGCTAAATTGCTGATCCAAAATAAAAACCCAGACTAGAATAGGGTTCTTAAA
ATCAAGTATCAATACAAAATAGAACACAATTAAAATCTTAATTGTTGGCTGGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGA
GGCCGAGGCGGGCGGATCATGAGGTTAGGAGAGCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTTTACTAAAAATACAAAAAAAA
TTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAGCTTGC
AGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCTAGACTCTGTGTCAAAAATAAATGACTAGATAAAAAAAAAAATT
GTTTGAGTACATTTTCCCTGCATTTTAGAGATTAGGACAGTGGTCACTTTCTAGTTGCCGTCTTCACAGACAAACTTGAAAGGTATTAAG
GAAAAAATTCCACATAGCTCTGGGCCTTTTTTGTATTCTGATTGCCACGTTAATCTGTAATCGTTAAGTACCCATGAAAGAATGTGTTTC
AGTATCAGTGCTTTTTTGGTACTTTAACAAGTATTGTAGGCACGGTGGATTTTTTTGAAATACCCATGTGTCCAATAGCAAGTTAAGGAA
CCTAGCGCATCAAATTTTGTTTTCTTCATTCATTTGGAACCTTATTTTCGCAAAAAACCTAGCTGGAATAATAATGCCATATTGTATTTT
GCACACTGCTTTATTTTCTAGAGGCTCTGGGAGCAAATTACATTCATCACATTACCTCTGCTCTCTCAAGATTAAAGTCTTTCAGCAACA
TTCTTTATTGTCATCATAAGGAAAAACTTTTATCGCAATGATAGTCAGTTCACATTAGTTTAGCACTATAGATAGTATTCAGAAATTGCT
TTCTCTTTGGTAAAGAAGATAAATAGGTGAATTTTATTGCCTGTGTTTTCAGGCTTCAGAGGTACCTGGCACCTTACTCAAGCAAAAACA
AAAAACAGCTTTACTTCAAAAGCATGTGCCTCTGGTAAATTATCCATCACTTTTGTTTTAAAGTGGTCCCTCCAAGAATAATGTGGCATA
CACAGTGGGTTTGGTTGTAAGGCAGATGTAATAGATGACTTCAAAAGCCTGCTCCTTACTGCACTCTGGACAAGGCCCTGGTCTGTATAG
TTTGGCTTCCTCTGTTAAGTCATTCTACAAGGTGACTTGCCATTTGAACTTTCGTAAGAGACCTCAGCAGTTAGACTGAGAAAAGTTAGA
GTGCTGTAGTTATGAAGTCATACATTTTTGATAAAATACCTGTGGAAAACCAGGGATCCTCTCCTGTTTCTCTCTCTTGCCTCCCCCTTT
CCCTCCATTCCTCTGTCGCCTCCCCCTCTCCTCCACTTTCTTTAAGAATCAGGGGGTACAGAATAACCTACAAACAACCTCTTCAAAGTA
CCCTTGGAAATTGAAGTTCAATCTTAAGTTTTTTGCTGTCTTTAATTTACTAGAATTGCCTAATTTTTAGTTGATTTCTCTACAGAGCTT
AGCTTGTGTAGTTATTTCTCTTTTACTGTTGCTTTGGTGTGTCTTGAAGTTTGATTGATTATTTTTGGTCATTGAGTTCTTAGTGTAGTT
TGCTAGATGATTATTAAGATTCTTTTGTGTCTGACACTTGTGGTGAGTTGCTTTTGAAATCTGTTGAGATTTCCATGTGAGAACTGATAA
TCAGGCTCTTGATCTGCTTCCCTAAATTACTTTTTTAGAGCCCAAACCCCAGGTTTAGGGTGAGGGTTTGTAATACAAAGAAACACTTCC
ATCACTTCTGCCCTTAACCCTTGCCTCTATTACCTAAGCTTAGTAAGTAGTTTTCTTAATATTGTCCAATGTTTGGTGTTATCTGCATTG
TTTTTTGTTTTTTTAATTGTGGTTGTTCTGACGTGTGAAATTTAAGGAAAGAGCCATTTTTTAAAAATGCCGAGCAGGGCAATGCAAGTA
CAGCCAAATATTAGACTTGATGTGCAATCTTCGGTCCTTTTTAATCTGGGGTATTATAGGCAGTACTTTAAATTGCAAAGTCTTCCGGGC
CTATTTTCCTCTACATTTTTGTAATTAACTCTGGGGGCTTACTTGTTTTGGCAGTACTGAAATCAAAGGAGCTGGTTCTTCTTTTCTCCC
AATTATTTTCATATGAAAGCACCTACAATTAGCCTGTTAGTCCTATTCAGATACATCAAATATCAGTGAATGCTTTACTATTCGCACATT
TAAGCATCTTTGTTTTACATAAAATTAGAGTATGAAAACCAGTGTTCAATTTTTTATCTTGTTGAGCTTGTAAAATGCCAGCAATTTAAA
ACTAGGACTTTTCCCCCCATAAGCCAAGGAGGTAGAATTACTAATACAAGGGTTAAAGAAGGTAGATTTTGTTTTCAATATTTGGGTAAT
ATTAGAAAGATTCTTCCCACAGGGAAGAACTAGCAAGTGTCCCAATTTTTTCCAAACGTTGGGGAGGGGAAAATTCACTGTATCATGAAA
CCCTAAGGGTTTGTTGCACTTCCTGCTTTTTAGGCCTGGATAACAGTATCACCATCCTTATTTACAGAAGGGTAAAACTGACTCTTAATG
AGAAAAGCTTTATAAGTTCAAGGGCTGTAAAATATGAACTACTTAGGGTCGTTTGCCTTCCATGGGAACTTGGCTAGACTTAGAAAAAGC
TGTTTGTTGTGCTAATGTAAAAGTGTCATACAATTTAGAAGATTTTTGAAGATGGTAAACTTAGAAGAATTCTATGTTCTGAAATGCACA
CTTTTAGAATGTTTTTCTTTGAAAACAGGCTAATAGTTTTTTCTTTTTTTGACAAAGTTTCAGCTCCTCTTTAAAGTTATTGTGTCATTT
TTCTGGTTTAAATTTCCCTTATATTTCCACCTGTAATGTCAGTGGCAACAACATCATACTTCACTTACTTGTTAATTTACTTTTTACCCT
TATTCTAAGAGCAAGTTGAGTTGAACTGAATCTTCCTTGTCTTAGTAACAATGTATAAATAGTGGCTTTTCTGTACAAAAGGTTGTAATG
CCTCCTGATGGATATAATTTTGTGATTGTATTTAAAAGTTGAATAAATCACACCAGCTTCCTGAAAATGTTCATAATGCATCTTTTGGAA
AACAAATACATGCCTACTTTGTGCATATTTGCATTAACATGGCAAAGATTGTATGAAATACCTGTTTTTCAGAAAATAAAGGTTCAGTCT

>62793_62793_2_PARN-SMG1_PARN_chr16_14645878_ENST00000420015_SMG1_chr16_18849788_ENST00000446231_length(amino acids)=1764AA_BP=464
MRRARARVGPRFRPLCRMEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERSSPDVKFVCQSSSIDFLASQ
GFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQ
RKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQ
FYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLC
FISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDT
SAFVSLSQPEQVKIGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGFAGAV
YGGGGQQAESKQSKREMEREITRSLFSSRVAEIKVNWFKNRDEMLVVLPKLDGSLDEYLSLQEQLTDVEKLQGKLLEEIEFLEGAEGVDH
PSHTLQHRYSEHTQLQTQQRAVQEAIQVKLNEFEQWITHYQAAFNNLEATQLASLLQEISTQMDLGPPSYVPATAFLQNAGQAHLISQCE
QLEGEVGALLQQRRSVLRGCLEQLHHYATVALQYPKAIFQKHRIEQWKTWMEELICNTTVERCQELYRKYEMQYAPQPPPTVCQFITATE
MTLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKVFLHENGEEGSLSLASVIISALCTLTRRNLMMEGAASSAGEQLVDLT
SRDGAWFLEELCSMSGNVTCLVQLLKQCHLVPQDLDIPNPMEASETVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGEYTLESMLHEL
DGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHYIDVARLLHAQYGELIQPRNGSVDETPKMSAGQMLLVAFDGMFAQVETAFSL
LVEKLNKMEIPIAWRKIDIIREARSTQVNFFDDDNHRQVLEEIFFLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQIVNVKTL
FRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFISALGVDIIAQVEAKDFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMN
RATVLASSYDTAWKKHDLVRRLETSISSCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTSMKKKLHTLSQIETSIATVQ
EKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKESQRASQVTFLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMC
SFASQFNSSVSELELRLLQRVDTGLEHPIGSSEWLLSAHKQLTQDMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVKH
LLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDNIQTVLFTLVQAMGQVRSQEHVEMLQEITPTLKELKTQSQSIYNNLVSFASPL
VTDATNECSSPTSSATYQPSFAAAVRSNTGQKTQPDVMSQNARKLIQKNLATSADTPPSTVPGTGKSVACSPKKAVRDPKTGKAVQERNS

--------------------------------------------------------------
>62793_62793_3_PARN-SMG1_PARN_chr16_14645878_ENST00000437198_SMG1_chr16_18849788_ENST00000389467_length(transcript)=10243nt_BP=1622nt
GCGCGCTGTTTCCGGAAGTCGCGGCCGGCGTCACCGCTGCGGCTGCCTCAGCTACTGCCGCAGTCGCCGCGGAATTCGGCGAGTAGAACC
GCTGAGGCGGGCGCGGGCCCGGGTGGGGCCAAGGTTCCGGCCACTCTGCAGAATGGAGATAATCAGGAGCAATTTTAAGAGTAATCTTCA
CAAAGTGTACCAGGCCATAGAGGAGGCCGACTTCTTCGCCATCGATGGGGAGTTTTCAGGAATCAGTGATGGACCTTCAGTCTCTGCATT
AACAAATGGTTTTGACACTCCAGAAGAGAGGTATCAGAAGCTTAAAAAGCATTCCATGGACTTTTTGCTATTTCAGTTTGGCCTTTGCAC
TTTTAAGTATGACTACACAGATTCAAAGTATATAACGAAGTCATTTAACTTCTATGTTTTCCCGAAACCCTTCAATAGATCCTCACCAGA
TGTCAAATTTGTTTGTCAGAGCTCCAGCATTGACTTTCTAGCAAGCCAGGGATTTGATTTTAATAAAGTTTTTCGAAATGGAATTCCATA
TTTAAATCAGGAAGAAGAAAGACAGTTAAGAGAGCAGTATGATGAAAAACGTTCACAGGCGAATGGTGCAGGAGCTCTGTCCTATGTATC
TCCTAACACTTCAAAATGTCCTGTCACGATTCCTGAGGATCAAAAGAAGTTTATTGACCAAGTGGTAGAGAAAATAGAGGATTTATTACA
AAGTGAAGAAAACAAGAACTTGGATTTAGAGCCATGTACCGGGTTCCAAAGAAAACTAATTTATCAGACTTTGAGCTGGAAGTATCCGAA
AGGCATTCATGTTGAGACTTTAGAAACTGAAAAGAAGGAGCGATATATAGTTATCAGCAAAGTAGATGAAGAAGAACGCAAAAGAAGAGA
GCAGCAGAAACATGCCAAAGAACAGGAGGAGCTGAATGATGCTGTGGGATTTTCTAGAGTCATTCACGCCATTGCTAATTCGGGAAAACT
TGTTATTGGACACAATATGCTCTTGGACGTCATGCACACAGTTCATCAGTTCTACTGCCCTCTGCCTGCGGACTTAAGTGAGTTTAAAGA
GATGACAACATGTGTTTTCCCCAGACTCTTGGATACTAAATTGATGGCCAGCACACAACCTTTTAAGGATATCATTAACAACACATCCCT
TGCGGAATTGGAAAAGCGGTTAAAAGAGACACCTTTCAACCCTCCTAAAGTTGAAAGTGCCGAAGGTTTTCCAAGTTATGACACAGCCTC
TGAACAACTCCACGAGGCAGGCTACGATGCCTACATCACAGGGCTGTGCTTCATCTCCATGGCCAATTACCTAGGTTCTTTTCTCAGCCC
TCCAAAAATTCATGTGTCTGCCAGATCAAAACTCATTGAACCTTTTTTTAACAAGTTATTTCTTATGAGGGTCATGGATATCCCCTATCT
AAACTTGGAAGGACCAGACTTGCAGCCTAAACGTGATCATGTTCTCCATGTGACATTCCCCAAAGAATGGAAAACCAGCGACCTTTACCA
GCTTTTCAGTGCCTTTGGTAACATTCAGATATCCTGGATTGATGACACATCAGCATTTGTTTCCCTTAGCCAGCCCGAGCAAGTAAAGAT
TGGTAAAAGCCTTAGAGTTCCTGAGAAAGTACCTTTTCGAATGACACAAAACATTGAAACAGCACTGGGTGTAACTGGAGTAGAAGGTGT
ATTTAGGCTTTCATGTGAGCAGGTTTTACACATTATGCGGCGTGGCAGAGAGACCCTGCTGACGCTGCTGGAGGCCTTTGTGTACGACCC
TCTGGTGGACTGGACAGCAGGAGGCGAGGCTGGGTTTGCTGGTGCTGTCTATGGTGGAGGTGGCCAGCAGGCCGAGAGCAAGCAGAGCAA
GAGAGAGATGGAGCGAGAGATCACCCGCAGCCTGTTTTCTTCTAGAGTAGCTGAGATTAAGGTGAACTGGTTTAAGAATAGAGATGAGAT
GCTGGTTGTGCTTCCCAAGTTGGACGGTAGCTTAGATGAATACCTAAGCTTGCAAGAGCAACTGACAGATGTGGAAAAACTGCAGGGCAA
ACTACTGGAGGAAATAGAGTTTCTAGAAGGAGCTGAAGGGGTGGATCATCCTTCTCATACTCTGCAACACAGGTATTCTGAGCACACCCA
ACTACAGACTCAGCAAAGAGCTGTTCAGGAAGCAATCCAGGTGAAGCTGAATGAATTTGAACAATGGATAACACATTATCAGGCTGCATT
CAATAATTTAGAAGCAACACAGCTTGCAAGCTTGCTTCAAGAGATAAGCACACAAATGGACCTTGGTCCTCCAAGTTACGTGCCAGCAAC
AGCCTTTCTGCAGAATGCTGGTCAGGCCCACTTGATTAGCCAGTGCGAGCAGCTGGAGGGGGAGGTTGGTGCTCTCCTGCAGCAGAGGCG
CTCCGTGCTCCGTGGCTGTCTGGAGCAACTGCATCACTATGCAACCGTGGCCCTGCAGTATCCGAAGGCCATATTTCAGAAACATCGAAT
TGAACAGTGGAAGACCTGGATGGAAGAGCTCATCTGTAACACCACAGTAGAGCGTTGTCAAGAGCTCTATAGGAAATATGAAATGCAATA
TGCTCCCCAGCCACCCCCAACAGTGTGTCAGTTCATCACTGCCACTGAAATGACCCTGCAGCGATACGCAGCAGACATCAACAGCAGACT
TATTAGACAAGTGGAACGCTTGAAACAGGAAGCTGTCACTGTGCCAGTTTGTGAAGATCAGTTGAAAGAAATTGAACGTTGCATTAAAGT
TTTCCTTCATGAGAATGGAGAAGAAGGATCTTTGAGTCTAGCAAGTGTTATTATTTCTGCCCTTTGTACCCTTACAAGGCGTAACCTGAT
GATGGAAGGTGCAGCGTCAAGTGCTGGAGAACAGCTGGTTGATCTGACTTCTCGGGATGGAGCCTGGTTCTTGGAGGAACTCTGCAGTAT
GAGCGGAAACGTCACCTGCTTGGTTCAGTTACTGAAGCAGTGCCACCTGGTGCCACAGGACTTAGATATCCCGAACCCCATGGAAGCGTC
TGAGACAGTTCACTTAGCCAATGGAGTGTATACCTCACTTCAGGAATTGAATTCGAATTTCCGGCAAATCATATTTCCAGAAGCACTTCG
ATGTTTAATGAAAGGGGAATACACGTTAGAAAGTATGCTGCATGAACTGGACGGTCTTATTGAGCAGACCACCGATGGCGTTCCCCTGCA
GACTCTAGTGGAATCTCTTCAGGCCTACTTAAGAAACGCAGCTATGGGACTGGAAGAAGAAACACATGCTCATTACATCGATGTTGCCAG
ACTACTACATGCTCAGTACGGTGAATTAATCCAACCGAGAAATGGTTCAGTTGATGAAACACCCAAAATGTCAGCTGGCCAGATGCTTTT
GGTAGCATTCGATGGCATGTTTGCTCAAGTTGAAACTGCTTTCAGCTTATTAGTTGAAAAGTTGAACAAGATGGAAATTCCCATAGCTTG
GCGAAAGATTGACATCATAAGGGAAGCCAGGAGTACTCAAGTTAATTTTTTTGATGATGATAATCACCGGCAGGTGCTAGAAGAGATTTT
CTTTCTAAAAAGACTACAGACTATTAAGGAGTTCTTCAGGCTCTGTGGTACCTTTTCTAAAACATTGTCAGGATCAAGTTCACTTGAAGA
TCAGAATACTGTGAATGGGCCTGTACAGATTGTCAATGTGAAAACCCTTTTTAGAAACTCTTGTTTCAGTGAAGACCAAATGGCCAAACC
TATCAAGGCATTCACAGCTGACTTTGTGAGGCAGCTCTTGATAGGGCTACCCAACCAAGCCCTCGGACTCACACTGTGCAGTTTTATCAG
TGCTCTGGGTGTAGACATCATTGCTCAAGTAGAGGCAAAGGACTTTGGTGCCGAAAGCAAAGTTTCTGTTGATGATCTCTGTAAGAAAGC
GGTGGAACATAACATCCAGATAGGGAAGTTCTCTCAGCTGGTTATGAACAGGGCAACTGTGTTAGCAAGTTCTTACGACACTGCCTGGAA
GAAGCATGACTTGGTGCGAAGGCTAGAAACCAGTATTTCTTCTTGTAAGACAAGCCTGCAGCGGGTTCAGCTGCATATTGCCATGTTTCA
GCAGTGGCAACATGAAGATCTACTTATCAATAGACCACAAGCCATGTCAGTCACACCTCCCCCACGGTCTGCTATCCTAACCAGCATGAA
AAAGAAGCTGCATACCCTGAGCCAGATTGAAACTTCTATTGCAACAGTTCAGGAGAAGCTAGCTGCACTTGAATCAAGTATTGAACAGCG
ACTCAAGTGGGCAGGTGGTGCCAACCCTGCATTGGCCCCTGTACTACAAGATTTTGAAGCAACGATAGCTGAAAGAAGAAATCTTGTCCT
TAAAGAGAGCCAAAGAGCAAGTCAGGTCACATTTCTCTGCAGCAATATCATTCATTTTGAAAGTTTACGAACAAGAACTGCAGAAGCCTT
AAACCTGGATGCGGCGTTATTTGAACTAATCAAGCGATGTCAGCAGATGTGTTCGTTTGCATCACAGTTTAACAGTTCAGTGTCTGAGTT
AGAGCTTCGTTTATTACAGAGAGTGGACACTGGTCTTGAACATCCTATTGGCAGCTCTGAATGGCTTTTGTCAGCACACAAACAGTTGAC
CCAGGATATGTCTACTCAGAGGGCAATTCAGACAGAGAAAGAGCAGCAGATAGAAACGGTCTGTGAAACAATTCAGAATCTGGTTGATAA
TATAAAGACTGTGCTCACTGGTCATAACCGACAGCTTGGAGATGTCAAACATCTCTTGAAAGCTATGGCTAAGGATGAAGAAGCTGCTCT
GGCAGATGGTGAAGATGTTCCCTATGAGAACAGTGTTAGGCAGTTTTTGGGTGAATATAAATCATGGCAAGACAACATTCAAACAGTTCT
ATTTACATTAGTCCAGGCTATGGGTCAGGTTCGAAGTCAAGAACACGTTGAAATGCTCCAGGAAATCACTCCCACCTTGAAAGAACTGAA
AACACAAAGTCAGAGTATCTATAATAATTTAGTGAGTTTTGCATCACCCTTAGTCACCGATGCAACAAATGAATGTTCGAGTCCAACGTC
ATCTGCTACTTATCAGCCATCCTTCGCTGCAGCAGTCCGGAGTAACACTGGCCAGAAGACTCAGCCTGATGTCATGTCACAGAATGCTAG
AAAGCTGATCCAAAAAAATCTTGCTACATCAGCTGATACTCCACCAAGCACCGTTCCAGGAACTGGCAAGAGTGTTGCTTGTAGTCCTAA
AAAGGCAGTCAGAGACCCTAAAACTGGGAAAGCGGTGCAAGAGAGAAACTCCTATGCAGTGAGTGTGTGGAAGAGAGTGAAAGCCAAGTT
AGAGGGCCGAGATGTTGATCCGAATAGGAGGATGTCAGTTGCTGAACAGGTTGACTATGTCATTAAGGAAGCAACTAATCTAGATAACTT
GGCTCAGCTGTATGAAGGTTGGACAGCCTGGGTGTGAATGGCAAGACAGTAGATGAGTCTGGTTAAGCGAGGTCAGACATCCACCAGAAT
CAACTCAGCCTCAGGCATCCAAAGCCACACCACAGTCGGTGGTGATGCAACTGGGGGCTTACTCTGAGGAAACCTAGGAAATCTCGGTGC
ACTAGGAAGTGAATCCCGCAGGACAGCTGCACTCAGGGATACGCCCAACACCATGGCCTGCAACCCCAGGGTCAAGGGTGAAGGAAAGCA
AGCTCACCGCCTGAACACGGAGATTGTCTTTCTGCCACAGAACAGCAGCAGACGTGTCGGGAGGTTAGCTGCGGAAAGAAATCGGGATGC
CGCGGAGCACAGAGTGATTTGGAACTCCATTCCACCTGACCCTGTGTGTACAATCCAGGAAAAAAACAAACCCCACTCAGAAACAGAGAA
AACTGGGGTCGCGAAGAAATCACAGCCAAGGAAGATTTGATGCATTCAGATTCTCGTGTAACACTTGTTGCTTGGCAACAGTACTGGTTG
GGTTGACCAGTAAGTAGAAAAAGGCTAAAGGCTATGCGATATGAATTTCAGAAATGGACTGAAAATGGAGAGCTATGTAACAGATACACT
ACAGTAGAAGAACTTACTTCTGAAATGAAGGGAAAAAAACCACCCCATCGTTCCCTACTCCTCCCCACCACTTACCCGTTCCCCCTTTAC
CTAATCTAGTAGATTAGCCATCTTTCAAATTCACTTTTATTTCAGTCCTTATATTTCATATACTTCCGTCTCGATGCTGTTAACAACTTC
TGATAACATGGAAAATTCAAGGATTGTTTAAAGGTCTGATGATCACACACAAAATGTAATTCCGGTTATTTAAGTCATTTCTGTGATTCT
ATCATGTACAGTTTCCAGAATTGTCACTGTGCATTCAAAAGTAATGAATCTAACAGACATTTGATTTAATGTACACTCCCTTTTGCTTAT
AGTGTGCATTTTTTTTGGAGGTCATTCAAATTTTCCCTCTTCTGTGATAGCTGTAGTTTCTTTCATAGAAAGTAGCTAATCCAGTGTAAT
CTTTTACCTTTTTAAAAACCAAGATAGAGTATCTATTAGAGTTTTACATTGTTGATGATAGATTAACAATAAAGTGATGTTCTGGTGGAG
GTAGACTGAAATTTTTTTAATTCATGTTTTTCATTTGATACTTTTAATTTACACTTAGTAAATTAAAAGTTGTTTAATTTACTTGGCATT
TTAGGACATGTACATGAAACAGTGAAAATGAGATCCACCAACATCTTTTATTAAGTTCAGTTATTAGTCTGTGAAGTGCTTTACTTTTTG
CACAATTTTAATAGCTTGCTATTCAGTAATACATTATAGTGAATTCATGATCAAGGTTTCCTTAAATTTAGCATTGCATTTCAGTACTGA
CTGTGTAAGCTAAATTGCTGATCCAAAATAAAAACCCAGACTAGAATAGGGTTCTTAAAATCAAGTATCAATACAAAATAGAACACAATT
AAAATCTTAATTGTTGGCTGGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCATGAGGTTAGGAG
AGCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTTTACTAAAAATACAAAAAAAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAGT
CCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAG
CCTGGGCAACAGAGCTAGACTCTGTGTCAAAAATAAATGACTAGATAAAAAAAAAAATTGTTTGAGTACATTTTCCCTGCATTTTAGAGA
TTAGGACAGTGGTCACTTTCTAGTTGCCGTCTTCACAGACAAACTTGAAAGGTATTAAGGAAAAAATTCCACATAGCTCTGGGCCTTTTT
TGTATTCTGATTGCCACGTTAATCTGTAATCGTTAAGTACCCATGAAAGAATGTGTTTCAGTATCAGTGCTTTTTTGGTACTTTAACAAG
TATTGTAGGCACGGTGGATTTTTTTGAAATACCCATGTGTCCAATAGCAAGTTAAGGAACCTAGCGCATCAAATTTTGTTTTCTTCATTC
ATTTGGAACCTTATTTTCGCAAAAAACCTAGCTGGAATAATAATGCCATATTGTATTTTGCACACTGCTTTATTTTCTAGAGGCTCTGGG
AGCAAATTACATTCATCACATTACCTCTGCTCTCTCAAGATTAAAGTCTTTCAGCAACATTCTTTATTGTCATCATAAGGAAAAACTTTT
ATCGCAATGATAGTCAGTTCACATTAGTTTAGCACTATAGATAGTATTCAGAAATTGCTTTCTCTTTGGTAAAGAAGATAAATAGGTGAA
TTTTATTGCCTGTGTTTTCAGGCTTCAGAGGTACCTGGCACCTTACTCAAGCAAAAACAAAAAACAGCTTTACTTCAAAAGCATGTGCCT
CTGGTAAATTATCCATCACTTTTGTTTTAAAGTGGTCCCTCCAAGAATAATGTGGCATACACAGTGGGTTTGGTTGTAAGGCAGATGTAA
TAGATGACTTCAAAAGCCTGCTCCTTACTGCACTCTGGACAAGGCCCTGGTCTGTATAGTTTGGCTTCCTCTGTTAAGTCATTCTACAAG
GTGACTTGCCATTTGAACTTTCGTAAGAGACCTCAGCAGTTAGACTGAGAAAAGTTAGAGTGCTGTAGTTATGAAGTCATACATTTTTGA
TAAAATACCTGTGGAAAACCAGGGATCCTCTCCTGTTTCTCTCTCTTGCCTCCCCCTTTCCCTCCATTCCTCTGTCGCCTCCCCCTCTCC
TCCACTTTCTTTAAGAATCAGGGGGTACAGAATAACCTACAAACAACCTCTTCAAAGTACCCTTGGAAATTGAAGTTCAATCTTAAGTTT
TTTGCTGTCTTTAATTTACTAGAATTGCCTAATTTTTAGTTGATTTCTCTACAGAGCTTAGCTTGTGTAGTTATTTCTCTTTTACTGTTG
CTTTGGTGTGTCTTGAAGTTTGATTGATTATTTTTGGTCATTGAGTTCTTAGTGTAGTTTGCTAGATGATTATTAAGATTCTTTTGTGTC
TGACACTTGTGGTGAGTTGCTTTTGAAATCTGTTGAGATTTCCATGTGAGAACTGATAATCAGGCTCTTGATCTGCTTCCCTAAATTACT
TTTTTAGAGCCCAAACCCCAGGTTTAGGGTGAGGGTTTGTAATACAAAGAAACACTTCCATCACTTCTGCCCTTAACCCTTGCCTCTATT
ACCTAAGCTTAGTAAGTAGTTTTCTTAATATTGTCCAATGTTTGGTGTTATCTGCATTGTTTTTTGTTTTTTTAATTGTGGTTGTTCTGA
CGTGTGAAATTTAAGGAAAGAGCCATTTTTTAAAAATGCCGAGCAGGGCAATGCAAGTACAGCCAAATATTAGACTTGATGTGCAATCTT
CGGTCCTTTTTAATCTGGGGTATTATAGGCAGTACTTTAAATTGCAAAGTCTTCCGGGCCTATTTTCCTCTACATTTTTGTAATTAACTC
TGGGGGCTTACTTGTTTTGGCAGTACTGAAATCAAAGGAGCTGGTTCTTCTTTTCTCCCAATTATTTTCATATGAAAGCACCTACAATTA
GCCTGTTAGTCCTATTCAGATACATCAAATATCAGTGAATGCTTTACTATTCGCACATTTAAGCATCTTTGTTTTACATAAAATTAGAGT
ATGAAAACCAGTGTTCAATTTTTTATCTTGTTGAGCTTGTAAAATGCCAGCAATTTAAAACTAGGACTTTTCCCCCCATAAGCCAAGGAG
GTAGAATTACTAATACAAGGGTTAAAGAAGGTAGATTTTGTTTTCAATATTTGGGTAATATTAGAAAGATTCTTCCCACAGGGAAGAACT
AGCAAGTGTCCCAATTTTTTCCAAACGTTGGGGAGGGGAAAATTCACTGTATCATGAAACCCTAAGGGTTTGTTGCACTTCCTGCTTTTT
AGGCCTGGATAACAGTATCACCATCCTTATTTACAGAAGGGTAAAACTGACTCTTAATGAGAAAAGCTTTATAAGTTCAAGGGCTGTAAA
ATATGAACTACTTAGGGTCGTTTGCCTTCCATGGGAACTTGGCTAGACTTAGAAAAAGCTGTTTGTTGTGCTAATGTAAAAGTGTCATAC
AATTTAGAAGATTTTTGAAGATGGTAAACTTAGAAGAATTCTATGTTCTGAAATGCACACTTTTAGAATGTTTTTCTTTGAAAACAGGCT
AATAGTTTTTTCTTTTTTTGACAAAGTTTCAGCTCCTCTTTAAAGTTATTGTGTCATTTTTCTGGTTTAAATTTCCCTTATATTTCCACC
TGTAATGTCAGTGGCAACAACATCATACTTCACTTACTTGTTAATTTACTTTTTACCCTTATTCTAAGAGCAAGTTGAGTTGAACTGAAT
CTTCCTTGTCTTAGTAACAATGTATAAATAGTGGCTTTTCTGTACAAAAGGTTGTAATGCCTCCTGATGGATATAATTTTGTGATTGTAT
TTAAAAGTTGAATAAATCACACCAGCTTCCTGAAAATGTTCATAATGCATCTTTTGGAAAACAAATACATGCCTACTTTGTGCATATTTG

>62793_62793_3_PARN-SMG1_PARN_chr16_14645878_ENST00000437198_SMG1_chr16_18849788_ENST00000389467_length(amino acids)=1811AA_BP=510
MRRARARVGPRFRPLCRMEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCT
FKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVS
PNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRRE
QQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSL
AELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVMDIPYL
NLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVKIGKSLRVPEKVPFRMTQNIETALGVTGVEGV
FRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGFAGAVYGGGGQQAESKQSKREMEREITRSLFSSRVAEIKVNWFKNRDEM
LVVLPKLDGSLDEYLSLQEQLTDVEKLQGKLLEEIEFLEGAEGVDHPSHTLQHRYSEHTQLQTQQRAVQEAIQVKLNEFEQWITHYQAAF
NNLEATQLASLLQEISTQMDLGPPSYVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQLHHYATVALQYPKAIFQKHRI
EQWKTWMEELICNTTVERCQELYRKYEMQYAPQPPPTVCQFITATEMTLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKV
FLHENGEEGSLSLASVIISALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTCLVQLLKQCHLVPQDLDIPNPMEAS
ETVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGEYTLESMLHELDGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHYIDVAR
LLHAQYGELIQPRNGSVDETPKMSAGQMLLVAFDGMFAQVETAFSLLVEKLNKMEIPIAWRKIDIIREARSTQVNFFDDDNHRQVLEEIF
FLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQIVNVKTLFRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFIS
ALGVDIIAQVEAKDFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMNRATVLASSYDTAWKKHDLVRRLETSISSCKTSLQRVQLHIAMFQ
QWQHEDLLINRPQAMSVTPPPRSAILTSMKKKLHTLSQIETSIATVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVL
KESQRASQVTFLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSELELRLLQRVDTGLEHPIGSSEWLLSAHKQLT
QDMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVKHLLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDNIQTVL
FTLVQAMGQVRSQEHVEMLQEITPTLKELKTQSQSIYNNLVSFASPLVTDATNECSSPTSSATYQPSFAAAVRSNTGQKTQPDVMSQNAR
KLIQKNLATSADTPPSTVPGTGKSVACSPKKAVRDPKTGKAVQERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNL

--------------------------------------------------------------
>62793_62793_4_PARN-SMG1_PARN_chr16_14645878_ENST00000437198_SMG1_chr16_18849788_ENST00000446231_length(transcript)=10240nt_BP=1622nt
GCGCGCTGTTTCCGGAAGTCGCGGCCGGCGTCACCGCTGCGGCTGCCTCAGCTACTGCCGCAGTCGCCGCGGAATTCGGCGAGTAGAACC
GCTGAGGCGGGCGCGGGCCCGGGTGGGGCCAAGGTTCCGGCCACTCTGCAGAATGGAGATAATCAGGAGCAATTTTAAGAGTAATCTTCA
CAAAGTGTACCAGGCCATAGAGGAGGCCGACTTCTTCGCCATCGATGGGGAGTTTTCAGGAATCAGTGATGGACCTTCAGTCTCTGCATT
AACAAATGGTTTTGACACTCCAGAAGAGAGGTATCAGAAGCTTAAAAAGCATTCCATGGACTTTTTGCTATTTCAGTTTGGCCTTTGCAC
TTTTAAGTATGACTACACAGATTCAAAGTATATAACGAAGTCATTTAACTTCTATGTTTTCCCGAAACCCTTCAATAGATCCTCACCAGA
TGTCAAATTTGTTTGTCAGAGCTCCAGCATTGACTTTCTAGCAAGCCAGGGATTTGATTTTAATAAAGTTTTTCGAAATGGAATTCCATA
TTTAAATCAGGAAGAAGAAAGACAGTTAAGAGAGCAGTATGATGAAAAACGTTCACAGGCGAATGGTGCAGGAGCTCTGTCCTATGTATC
TCCTAACACTTCAAAATGTCCTGTCACGATTCCTGAGGATCAAAAGAAGTTTATTGACCAAGTGGTAGAGAAAATAGAGGATTTATTACA
AAGTGAAGAAAACAAGAACTTGGATTTAGAGCCATGTACCGGGTTCCAAAGAAAACTAATTTATCAGACTTTGAGCTGGAAGTATCCGAA
AGGCATTCATGTTGAGACTTTAGAAACTGAAAAGAAGGAGCGATATATAGTTATCAGCAAAGTAGATGAAGAAGAACGCAAAAGAAGAGA
GCAGCAGAAACATGCCAAAGAACAGGAGGAGCTGAATGATGCTGTGGGATTTTCTAGAGTCATTCACGCCATTGCTAATTCGGGAAAACT
TGTTATTGGACACAATATGCTCTTGGACGTCATGCACACAGTTCATCAGTTCTACTGCCCTCTGCCTGCGGACTTAAGTGAGTTTAAAGA
GATGACAACATGTGTTTTCCCCAGACTCTTGGATACTAAATTGATGGCCAGCACACAACCTTTTAAGGATATCATTAACAACACATCCCT
TGCGGAATTGGAAAAGCGGTTAAAAGAGACACCTTTCAACCCTCCTAAAGTTGAAAGTGCCGAAGGTTTTCCAAGTTATGACACAGCCTC
TGAACAACTCCACGAGGCAGGCTACGATGCCTACATCACAGGGCTGTGCTTCATCTCCATGGCCAATTACCTAGGTTCTTTTCTCAGCCC
TCCAAAAATTCATGTGTCTGCCAGATCAAAACTCATTGAACCTTTTTTTAACAAGTTATTTCTTATGAGGGTCATGGATATCCCCTATCT
AAACTTGGAAGGACCAGACTTGCAGCCTAAACGTGATCATGTTCTCCATGTGACATTCCCCAAAGAATGGAAAACCAGCGACCTTTACCA
GCTTTTCAGTGCCTTTGGTAACATTCAGATATCCTGGATTGATGACACATCAGCATTTGTTTCCCTTAGCCAGCCCGAGCAAGTAAAGAT
TGGTAAAAGCCTTAGAGTTCCTGAGAAAGTACCTTTTCGAATGACACAAAACATTGAAACAGCACTGGGTGTAACTGGAGTAGAAGGTGT
ATTTAGGCTTTCATGTGAGCAGGTTTTACACATTATGCGGCGTGGCAGAGAGACCCTGCTGACGCTGCTGGAGGCCTTTGTGTACGACCC
TCTGGTGGACTGGACAGCAGGAGGCGAGGCTGGGTTTGCTGGTGCTGTCTATGGTGGAGGTGGCCAGCAGGCCGAGAGCAAGCAGAGCAA
GAGAGAGATGGAGCGAGAGATCACCCGCAGCCTGTTTTCTTCTAGAGTAGCTGAGATTAAGGTGAACTGGTTTAAGAATAGAGATGAGAT
GCTGGTTGTGCTTCCCAAGTTGGACGGTAGCTTAGATGAATACCTAAGCTTGCAAGAGCAACTGACAGATGTGGAAAAACTGCAGGGCAA
ACTACTGGAGGAAATAGAGTTTCTAGAAGGAGCTGAAGGGGTGGATCATCCTTCTCATACTCTGCAACACAGGTATTCTGAGCACACCCA
ACTACAGACTCAGCAAAGAGCTGTTCAGGAAGCAATCCAGGTGAAGCTGAATGAATTTGAACAATGGATAACACATTATCAGGCTGCATT
CAATAATTTAGAAGCAACACAGCTTGCAAGCTTGCTTCAAGAGATAAGCACACAAATGGACCTTGGTCCTCCAAGTTACGTGCCAGCAAC
AGCCTTTCTGCAGAATGCTGGTCAGGCCCACTTGATTAGCCAGTGCGAGCAGCTGGAGGGGGAGGTTGGTGCTCTCCTGCAGCAGAGGCG
CTCCGTGCTCCGTGGCTGTCTGGAGCAACTGCATCACTATGCAACCGTGGCCCTGCAGTATCCGAAGGCCATATTTCAGAAACATCGAAT
TGAACAGTGGAAGACCTGGATGGAAGAGCTCATCTGTAACACCACAGTAGAGCGTTGTCAAGAGCTCTATAGGAAATATGAAATGCAATA
TGCTCCCCAGCCACCCCCAACAGTGTGTCAGTTCATCACTGCCACTGAAATGACCCTGCAGCGATACGCAGCAGACATCAACAGCAGACT
TATTAGACAAGTGGAACGCTTGAAACAGGAAGCTGTCACTGTGCCAGTTTGTGAAGATCAGTTGAAAGAAATTGAACGTTGCATTAAAGT
TTTCCTTCATGAGAATGGAGAAGAAGGATCTTTGAGTCTAGCAAGTGTTATTATTTCTGCCCTTTGTACCCTTACAAGGCGTAACCTGAT
GATGGAAGGTGCAGCGTCAAGTGCTGGAGAACAGCTGGTTGATCTGACTTCTCGGGATGGAGCCTGGTTCTTGGAGGAACTCTGCAGTAT
GAGCGGAAACGTCACCTGCTTGGTTCAGTTACTGAAGCAGTGCCACCTGGTGCCACAGGACTTAGATATCCCGAACCCCATGGAAGCGTC
TGAGACAGTTCACTTAGCCAATGGAGTGTATACCTCACTTCAGGAATTGAATTCGAATTTCCGGCAAATCATATTTCCAGAAGCACTTCG
ATGTTTAATGAAAGGGGAATACACGTTAGAAAGTATGCTGCATGAACTGGACGGTCTTATTGAGCAGACCACCGATGGCGTTCCCCTGCA
GACTCTAGTGGAATCTCTTCAGGCCTACTTAAGAAACGCAGCTATGGGACTGGAAGAAGAAACACATGCTCATTACATCGATGTTGCCAG
ACTACTACATGCTCAGTACGGTGAATTAATCCAACCGAGAAATGGTTCAGTTGATGAAACACCCAAAATGTCAGCTGGCCAGATGCTTTT
GGTAGCATTCGATGGCATGTTTGCTCAAGTTGAAACTGCTTTCAGCTTATTAGTTGAAAAGTTGAACAAGATGGAAATTCCCATAGCTTG
GCGAAAGATTGACATCATAAGGGAAGCCAGGAGTACTCAAGTTAATTTTTTTGATGATGATAATCACCGGCAGGTGCTAGAAGAGATTTT
CTTTCTAAAAAGACTACAGACTATTAAGGAGTTCTTCAGGCTCTGTGGTACCTTTTCTAAAACATTGTCAGGATCAAGTTCACTTGAAGA
TCAGAATACTGTGAATGGGCCTGTACAGATTGTCAATGTGAAAACCCTTTTTAGAAACTCTTGTTTCAGTGAAGACCAAATGGCCAAACC
TATCAAGGCATTCACAGCTGACTTTGTGAGGCAGCTCTTGATAGGGCTACCCAACCAAGCCCTCGGACTCACACTGTGCAGTTTTATCAG
TGCTCTGGGTGTAGACATCATTGCTCAAGTAGAGGCAAAGGACTTTGGTGCCGAAAGCAAAGTTTCTGTTGATGATCTCTGTAAGAAAGC
GGTGGAACATAACATCCAGATAGGGAAGTTCTCTCAGCTGGTTATGAACAGGGCAACTGTGTTAGCAAGTTCTTACGACACTGCCTGGAA
GAAGCATGACTTGGTGCGAAGGCTAGAAACCAGTATTTCTTCTTGTAAGACAAGCCTGCAGCGGGTTCAGCTGCATATTGCCATGTTTCA
GTGGCAACATGAAGATCTACTTATCAATAGACCACAAGCCATGTCAGTCACACCTCCCCCACGGTCTGCTATCCTAACCAGCATGAAAAA
GAAGCTGCATACCCTGAGCCAGATTGAAACTTCTATTGCAACAGTTCAGGAGAAGCTAGCTGCACTTGAATCAAGTATTGAACAGCGACT
CAAGTGGGCAGGTGGTGCCAACCCTGCATTGGCCCCTGTACTACAAGATTTTGAAGCAACGATAGCTGAAAGAAGAAATCTTGTCCTTAA
AGAGAGCCAAAGAGCAAGTCAGGTCACATTTCTCTGCAGCAATATCATTCATTTTGAAAGTTTACGAACAAGAACTGCAGAAGCCTTAAA
CCTGGATGCGGCGTTATTTGAACTAATCAAGCGATGTCAGCAGATGTGTTCGTTTGCATCACAGTTTAACAGTTCAGTGTCTGAGTTAGA
GCTTCGTTTATTACAGAGAGTGGACACTGGTCTTGAACATCCTATTGGCAGCTCTGAATGGCTTTTGTCAGCACACAAACAGTTGACCCA
GGATATGTCTACTCAGAGGGCAATTCAGACAGAGAAAGAGCAGCAGATAGAAACGGTCTGTGAAACAATTCAGAATCTGGTTGATAATAT
AAAGACTGTGCTCACTGGTCATAACCGACAGCTTGGAGATGTCAAACATCTCTTGAAAGCTATGGCTAAGGATGAAGAAGCTGCTCTGGC
AGATGGTGAAGATGTTCCCTATGAGAACAGTGTTAGGCAGTTTTTGGGTGAATATAAATCATGGCAAGACAACATTCAAACAGTTCTATT
TACATTAGTCCAGGCTATGGGTCAGGTTCGAAGTCAAGAACACGTTGAAATGCTCCAGGAAATCACTCCCACCTTGAAAGAACTGAAAAC
ACAAAGTCAGAGTATCTATAATAATTTAGTGAGTTTTGCATCACCCTTAGTCACCGATGCAACAAATGAATGTTCGAGTCCAACGTCATC
TGCTACTTATCAGCCATCCTTCGCTGCAGCAGTCCGGAGTAACACTGGCCAGAAGACTCAGCCTGATGTCATGTCACAGAATGCTAGAAA
GCTGATCCAAAAAAATCTTGCTACATCAGCTGATACTCCACCAAGCACCGTTCCAGGAACTGGCAAGAGTGTTGCTTGTAGTCCTAAAAA
GGCAGTCAGAGACCCTAAAACTGGGAAAGCGGTGCAAGAGAGAAACTCCTATGCAGTGAGTGTGTGGAAGAGAGTGAAAGCCAAGTTAGA
GGGCCGAGATGTTGATCCGAATAGGAGGATGTCAGTTGCTGAACAGGTTGACTATGTCATTAAGGAAGCAACTAATCTAGATAACTTGGC
TCAGCTGTATGAAGGTTGGACAGCCTGGGTGTGAATGGCAAGACAGTAGATGAGTCTGGTTAAGCGAGGTCAGACATCCACCAGAATCAA
CTCAGCCTCAGGCATCCAAAGCCACACCACAGTCGGTGGTGATGCAACTGGGGGCTTACTCTGAGGAAACCTAGGAAATCTCGGTGCACT
AGGAAGTGAATCCCGCAGGACAGCTGCACTCAGGGATACGCCCAACACCATGGCCTGCAACCCCAGGGTCAAGGGTGAAGGAAAGCAAGC
TCACCGCCTGAACACGGAGATTGTCTTTCTGCCACAGAACAGCAGCAGACGTGTCGGGAGGTTAGCTGCGGAAAGAAATCGGGATGCCGC
GGAGCACAGAGTGATTTGGAACTCCATTCCACCTGACCCTGTGTGTACAATCCAGGAAAAAAACAAACCCCACTCAGAAACAGAGAAAAC
TGGGGTCGCGAAGAAATCACAGCCAAGGAAGATTTGATGCATTCAGATTCTCGTGTAACACTTGTTGCTTGGCAACAGTACTGGTTGGGT
TGACCAGTAAGTAGAAAAAGGCTAAAGGCTATGCGATATGAATTTCAGAAATGGACTGAAAATGGAGAGCTATGTAACAGATACACTACA
GTAGAAGAACTTACTTCTGAAATGAAGGGAAAAAAACCACCCCATCGTTCCCTACTCCTCCCCACCACTTACCCGTTCCCCCTTTACCTA
ATCTAGTAGATTAGCCATCTTTCAAATTCACTTTTATTTCAGTCCTTATATTTCATATACTTCCGTCTCGATGCTGTTAACAACTTCTGA
TAACATGGAAAATTCAAGGATTGTTTAAAGGTCTGATGATCACACACAAAATGTAATTCCGGTTATTTAAGTCATTTCTGTGATTCTATC
ATGTACAGTTTCCAGAATTGTCACTGTGCATTCAAAAGTAATGAATCTAACAGACATTTGATTTAATGTACACTCCCTTTTGCTTATAGT
GTGCATTTTTTTTGGAGGTCATTCAAATTTTCCCTCTTCTGTGATAGCTGTAGTTTCTTTCATAGAAAGTAGCTAATCCAGTGTAATCTT
TTACCTTTTTAAAAACCAAGATAGAGTATCTATTAGAGTTTTACATTGTTGATGATAGATTAACAATAAAGTGATGTTCTGGTGGAGGTA
GACTGAAATTTTTTTAATTCATGTTTTTCATTTGATACTTTTAATTTACACTTAGTAAATTAAAAGTTGTTTAATTTACTTGGCATTTTA
GGACATGTACATGAAACAGTGAAAATGAGATCCACCAACATCTTTTATTAAGTTCAGTTATTAGTCTGTGAAGTGCTTTACTTTTTGCAC
AATTTTAATAGCTTGCTATTCAGTAATACATTATAGTGAATTCATGATCAAGGTTTCCTTAAATTTAGCATTGCATTTCAGTACTGACTG
TGTAAGCTAAATTGCTGATCCAAAATAAAAACCCAGACTAGAATAGGGTTCTTAAAATCAAGTATCAATACAAAATAGAACACAATTAAA
ATCTTAATTGTTGGCTGGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCATGAGGTTAGGAGAGC
GAGACCATCCTGGCTAACACGGTGAAACCCCGTCTTTACTAAAAATACAAAAAAAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCC
AGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCT
GGGCAACAGAGCTAGACTCTGTGTCAAAAATAAATGACTAGATAAAAAAAAAAATTGTTTGAGTACATTTTCCCTGCATTTTAGAGATTA
GGACAGTGGTCACTTTCTAGTTGCCGTCTTCACAGACAAACTTGAAAGGTATTAAGGAAAAAATTCCACATAGCTCTGGGCCTTTTTTGT
ATTCTGATTGCCACGTTAATCTGTAATCGTTAAGTACCCATGAAAGAATGTGTTTCAGTATCAGTGCTTTTTTGGTACTTTAACAAGTAT
TGTAGGCACGGTGGATTTTTTTGAAATACCCATGTGTCCAATAGCAAGTTAAGGAACCTAGCGCATCAAATTTTGTTTTCTTCATTCATT
TGGAACCTTATTTTCGCAAAAAACCTAGCTGGAATAATAATGCCATATTGTATTTTGCACACTGCTTTATTTTCTAGAGGCTCTGGGAGC
AAATTACATTCATCACATTACCTCTGCTCTCTCAAGATTAAAGTCTTTCAGCAACATTCTTTATTGTCATCATAAGGAAAAACTTTTATC
GCAATGATAGTCAGTTCACATTAGTTTAGCACTATAGATAGTATTCAGAAATTGCTTTCTCTTTGGTAAAGAAGATAAATAGGTGAATTT
TATTGCCTGTGTTTTCAGGCTTCAGAGGTACCTGGCACCTTACTCAAGCAAAAACAAAAAACAGCTTTACTTCAAAAGCATGTGCCTCTG
GTAAATTATCCATCACTTTTGTTTTAAAGTGGTCCCTCCAAGAATAATGTGGCATACACAGTGGGTTTGGTTGTAAGGCAGATGTAATAG
ATGACTTCAAAAGCCTGCTCCTTACTGCACTCTGGACAAGGCCCTGGTCTGTATAGTTTGGCTTCCTCTGTTAAGTCATTCTACAAGGTG
ACTTGCCATTTGAACTTTCGTAAGAGACCTCAGCAGTTAGACTGAGAAAAGTTAGAGTGCTGTAGTTATGAAGTCATACATTTTTGATAA
AATACCTGTGGAAAACCAGGGATCCTCTCCTGTTTCTCTCTCTTGCCTCCCCCTTTCCCTCCATTCCTCTGTCGCCTCCCCCTCTCCTCC
ACTTTCTTTAAGAATCAGGGGGTACAGAATAACCTACAAACAACCTCTTCAAAGTACCCTTGGAAATTGAAGTTCAATCTTAAGTTTTTT
GCTGTCTTTAATTTACTAGAATTGCCTAATTTTTAGTTGATTTCTCTACAGAGCTTAGCTTGTGTAGTTATTTCTCTTTTACTGTTGCTT
TGGTGTGTCTTGAAGTTTGATTGATTATTTTTGGTCATTGAGTTCTTAGTGTAGTTTGCTAGATGATTATTAAGATTCTTTTGTGTCTGA
CACTTGTGGTGAGTTGCTTTTGAAATCTGTTGAGATTTCCATGTGAGAACTGATAATCAGGCTCTTGATCTGCTTCCCTAAATTACTTTT
TTAGAGCCCAAACCCCAGGTTTAGGGTGAGGGTTTGTAATACAAAGAAACACTTCCATCACTTCTGCCCTTAACCCTTGCCTCTATTACC
TAAGCTTAGTAAGTAGTTTTCTTAATATTGTCCAATGTTTGGTGTTATCTGCATTGTTTTTTGTTTTTTTAATTGTGGTTGTTCTGACGT
GTGAAATTTAAGGAAAGAGCCATTTTTTAAAAATGCCGAGCAGGGCAATGCAAGTACAGCCAAATATTAGACTTGATGTGCAATCTTCGG
TCCTTTTTAATCTGGGGTATTATAGGCAGTACTTTAAATTGCAAAGTCTTCCGGGCCTATTTTCCTCTACATTTTTGTAATTAACTCTGG
GGGCTTACTTGTTTTGGCAGTACTGAAATCAAAGGAGCTGGTTCTTCTTTTCTCCCAATTATTTTCATATGAAAGCACCTACAATTAGCC
TGTTAGTCCTATTCAGATACATCAAATATCAGTGAATGCTTTACTATTCGCACATTTAAGCATCTTTGTTTTACATAAAATTAGAGTATG
AAAACCAGTGTTCAATTTTTTATCTTGTTGAGCTTGTAAAATGCCAGCAATTTAAAACTAGGACTTTTCCCCCCATAAGCCAAGGAGGTA
GAATTACTAATACAAGGGTTAAAGAAGGTAGATTTTGTTTTCAATATTTGGGTAATATTAGAAAGATTCTTCCCACAGGGAAGAACTAGC
AAGTGTCCCAATTTTTTCCAAACGTTGGGGAGGGGAAAATTCACTGTATCATGAAACCCTAAGGGTTTGTTGCACTTCCTGCTTTTTAGG
CCTGGATAACAGTATCACCATCCTTATTTACAGAAGGGTAAAACTGACTCTTAATGAGAAAAGCTTTATAAGTTCAAGGGCTGTAAAATA
TGAACTACTTAGGGTCGTTTGCCTTCCATGGGAACTTGGCTAGACTTAGAAAAAGCTGTTTGTTGTGCTAATGTAAAAGTGTCATACAAT
TTAGAAGATTTTTGAAGATGGTAAACTTAGAAGAATTCTATGTTCTGAAATGCACACTTTTAGAATGTTTTTCTTTGAAAACAGGCTAAT
AGTTTTTTCTTTTTTTGACAAAGTTTCAGCTCCTCTTTAAAGTTATTGTGTCATTTTTCTGGTTTAAATTTCCCTTATATTTCCACCTGT
AATGTCAGTGGCAACAACATCATACTTCACTTACTTGTTAATTTACTTTTTACCCTTATTCTAAGAGCAAGTTGAGTTGAACTGAATCTT
CCTTGTCTTAGTAACAATGTATAAATAGTGGCTTTTCTGTACAAAAGGTTGTAATGCCTCCTGATGGATATAATTTTGTGATTGTATTTA
AAAGTTGAATAAATCACACCAGCTTCCTGAAAATGTTCATAATGCATCTTTTGGAAAACAAATACATGCCTACTTTGTGCATATTTGCAT

>62793_62793_4_PARN-SMG1_PARN_chr16_14645878_ENST00000437198_SMG1_chr16_18849788_ENST00000446231_length(amino acids)=1810AA_BP=510
MRRARARVGPRFRPLCRMEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCT
FKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVS
PNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRRE
QQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSL
AELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVMDIPYL
NLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVKIGKSLRVPEKVPFRMTQNIETALGVTGVEGV
FRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGFAGAVYGGGGQQAESKQSKREMEREITRSLFSSRVAEIKVNWFKNRDEM
LVVLPKLDGSLDEYLSLQEQLTDVEKLQGKLLEEIEFLEGAEGVDHPSHTLQHRYSEHTQLQTQQRAVQEAIQVKLNEFEQWITHYQAAF
NNLEATQLASLLQEISTQMDLGPPSYVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQLHHYATVALQYPKAIFQKHRI
EQWKTWMEELICNTTVERCQELYRKYEMQYAPQPPPTVCQFITATEMTLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKV
FLHENGEEGSLSLASVIISALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTCLVQLLKQCHLVPQDLDIPNPMEAS
ETVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGEYTLESMLHELDGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHYIDVAR
LLHAQYGELIQPRNGSVDETPKMSAGQMLLVAFDGMFAQVETAFSLLVEKLNKMEIPIAWRKIDIIREARSTQVNFFDDDNHRQVLEEIF
FLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQIVNVKTLFRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFIS
ALGVDIIAQVEAKDFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMNRATVLASSYDTAWKKHDLVRRLETSISSCKTSLQRVQLHIAMFQ
WQHEDLLINRPQAMSVTPPPRSAILTSMKKKLHTLSQIETSIATVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLK
ESQRASQVTFLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSELELRLLQRVDTGLEHPIGSSEWLLSAHKQLTQ
DMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVKHLLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDNIQTVLF
TLVQAMGQVRSQEHVEMLQEITPTLKELKTQSQSIYNNLVSFASPLVTDATNECSSPTSSATYQPSFAAAVRSNTGQKTQPDVMSQNARK
LIQKNLATSADTPPSTVPGTGKSVACSPKKAVRDPKTGKAVQERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLA

--------------------------------------------------------------
>62793_62793_5_PARN-SMG1_PARN_chr16_14645878_ENST00000539279_SMG1_chr16_18849788_ENST00000389467_length(transcript)=9689nt_BP=1068nt
GTCACCGCTGCGGCTGCCTCAGCTACTGCCGCAGTCGCCGCGGAATTCGGCGAGTAGAACCGCTGAGGCGGGCGCGGGCCCGGGTGGGGC
CAAGGTTCCGGCCACTCTGCAGAATGGAGATAATCAGGAGCAATTTTAAGAGTAATCTTCACAAAGTGTACCAGGCCATAGAGGAGGCCG
ACTTCTTCGCCATCGATGGGGAGTTTTCAGGAATCAGTGATGGACCTTCAGTCTCTGCATTAACAAATGGTTTTGACACTCCAGAAGAGA
GGTATCAGAAGCTTAAAAAGAAGGAGCGATATATAGTTATCAGCAAAGTAGATGAAGAAGAACGCAAAAGAAGAGAGCAGCAGAAACATG
CCAAAGAACAGGAGGAGCTGAATGATGCTGTGGGATTTTCTAGAGTCATTCACGCCATTGCTAATTCGGGAAAACTTGTTATTGGACACA
ATATGCTCTTGGACGTCATGCACACAGTTCATCAGTTCTACTGCCCTCTGCCTGCGGACTTAAGTGAGTTTAAAGAGATGACAACATGTG
TTTTCCCCAGACTCTTGGATACTAAATTGATGGCCAGCACACAACCTTTTAAGGATATCATTAACAACACATCCCTTGCGGAATTGGAAA
AGCGGTTAAAAGAGACACCTTTCAACCCTCCTAAAGTTGAAAGTGCCGAAGGTTTTCCAAGTTATGACACAGCCTCTGAACAACTCCACG
AGGCAGGCTACGATGCCTACATCACAGGGCTGTGCTTCATCTCCATGGCCAATTACCTAGGTTCTTTTCTCAGCCCTCCAAAAATTCATG
TGTCTGCCAGATCAAAACTCATTGAACCTTTTTTTAACAAGTTATTTCTTATGAGGGTCATGGATATCCCCTATCTAAACTTGGAAGGAC
CAGACTTGCAGCCTAAACGTGATCATGTTCTCCATGTGACATTCCCCAAAGAATGGAAAACCAGCGACCTTTACCAGCTTTTCAGTGCCT
TTGGTAACATTCAGATATCCTGGATTGATGACACATCAGCATTTGTTTCCCTTAGCCAGCCCGAGCAAGTAAAGATTGGTAAAAGCCTTA
GAGTTCCTGAGAAAGTACCTTTTCGAATGACACAAAACATTGAAACAGCACTGGGTGTAACTGGAGTAGAAGGTGTATTTAGGCTTTCAT
GTGAGCAGGTTTTACACATTATGCGGCGTGGCAGAGAGACCCTGCTGACGCTGCTGGAGGCCTTTGTGTACGACCCTCTGGTGGACTGGA
CAGCAGGAGGCGAGGCTGGGTTTGCTGGTGCTGTCTATGGTGGAGGTGGCCAGCAGGCCGAGAGCAAGCAGAGCAAGAGAGAGATGGAGC
GAGAGATCACCCGCAGCCTGTTTTCTTCTAGAGTAGCTGAGATTAAGGTGAACTGGTTTAAGAATAGAGATGAGATGCTGGTTGTGCTTC
CCAAGTTGGACGGTAGCTTAGATGAATACCTAAGCTTGCAAGAGCAACTGACAGATGTGGAAAAACTGCAGGGCAAACTACTGGAGGAAA
TAGAGTTTCTAGAAGGAGCTGAAGGGGTGGATCATCCTTCTCATACTCTGCAACACAGGTATTCTGAGCACACCCAACTACAGACTCAGC
AAAGAGCTGTTCAGGAAGCAATCCAGGTGAAGCTGAATGAATTTGAACAATGGATAACACATTATCAGGCTGCATTCAATAATTTAGAAG
CAACACAGCTTGCAAGCTTGCTTCAAGAGATAAGCACACAAATGGACCTTGGTCCTCCAAGTTACGTGCCAGCAACAGCCTTTCTGCAGA
ATGCTGGTCAGGCCCACTTGATTAGCCAGTGCGAGCAGCTGGAGGGGGAGGTTGGTGCTCTCCTGCAGCAGAGGCGCTCCGTGCTCCGTG
GCTGTCTGGAGCAACTGCATCACTATGCAACCGTGGCCCTGCAGTATCCGAAGGCCATATTTCAGAAACATCGAATTGAACAGTGGAAGA
CCTGGATGGAAGAGCTCATCTGTAACACCACAGTAGAGCGTTGTCAAGAGCTCTATAGGAAATATGAAATGCAATATGCTCCCCAGCCAC
CCCCAACAGTGTGTCAGTTCATCACTGCCACTGAAATGACCCTGCAGCGATACGCAGCAGACATCAACAGCAGACTTATTAGACAAGTGG
AACGCTTGAAACAGGAAGCTGTCACTGTGCCAGTTTGTGAAGATCAGTTGAAAGAAATTGAACGTTGCATTAAAGTTTTCCTTCATGAGA
ATGGAGAAGAAGGATCTTTGAGTCTAGCAAGTGTTATTATTTCTGCCCTTTGTACCCTTACAAGGCGTAACCTGATGATGGAAGGTGCAG
CGTCAAGTGCTGGAGAACAGCTGGTTGATCTGACTTCTCGGGATGGAGCCTGGTTCTTGGAGGAACTCTGCAGTATGAGCGGAAACGTCA
CCTGCTTGGTTCAGTTACTGAAGCAGTGCCACCTGGTGCCACAGGACTTAGATATCCCGAACCCCATGGAAGCGTCTGAGACAGTTCACT
TAGCCAATGGAGTGTATACCTCACTTCAGGAATTGAATTCGAATTTCCGGCAAATCATATTTCCAGAAGCACTTCGATGTTTAATGAAAG
GGGAATACACGTTAGAAAGTATGCTGCATGAACTGGACGGTCTTATTGAGCAGACCACCGATGGCGTTCCCCTGCAGACTCTAGTGGAAT
CTCTTCAGGCCTACTTAAGAAACGCAGCTATGGGACTGGAAGAAGAAACACATGCTCATTACATCGATGTTGCCAGACTACTACATGCTC
AGTACGGTGAATTAATCCAACCGAGAAATGGTTCAGTTGATGAAACACCCAAAATGTCAGCTGGCCAGATGCTTTTGGTAGCATTCGATG
GCATGTTTGCTCAAGTTGAAACTGCTTTCAGCTTATTAGTTGAAAAGTTGAACAAGATGGAAATTCCCATAGCTTGGCGAAAGATTGACA
TCATAAGGGAAGCCAGGAGTACTCAAGTTAATTTTTTTGATGATGATAATCACCGGCAGGTGCTAGAAGAGATTTTCTTTCTAAAAAGAC
TACAGACTATTAAGGAGTTCTTCAGGCTCTGTGGTACCTTTTCTAAAACATTGTCAGGATCAAGTTCACTTGAAGATCAGAATACTGTGA
ATGGGCCTGTACAGATTGTCAATGTGAAAACCCTTTTTAGAAACTCTTGTTTCAGTGAAGACCAAATGGCCAAACCTATCAAGGCATTCA
CAGCTGACTTTGTGAGGCAGCTCTTGATAGGGCTACCCAACCAAGCCCTCGGACTCACACTGTGCAGTTTTATCAGTGCTCTGGGTGTAG
ACATCATTGCTCAAGTAGAGGCAAAGGACTTTGGTGCCGAAAGCAAAGTTTCTGTTGATGATCTCTGTAAGAAAGCGGTGGAACATAACA
TCCAGATAGGGAAGTTCTCTCAGCTGGTTATGAACAGGGCAACTGTGTTAGCAAGTTCTTACGACACTGCCTGGAAGAAGCATGACTTGG
TGCGAAGGCTAGAAACCAGTATTTCTTCTTGTAAGACAAGCCTGCAGCGGGTTCAGCTGCATATTGCCATGTTTCAGCAGTGGCAACATG
AAGATCTACTTATCAATAGACCACAAGCCATGTCAGTCACACCTCCCCCACGGTCTGCTATCCTAACCAGCATGAAAAAGAAGCTGCATA
CCCTGAGCCAGATTGAAACTTCTATTGCAACAGTTCAGGAGAAGCTAGCTGCACTTGAATCAAGTATTGAACAGCGACTCAAGTGGGCAG
GTGGTGCCAACCCTGCATTGGCCCCTGTACTACAAGATTTTGAAGCAACGATAGCTGAAAGAAGAAATCTTGTCCTTAAAGAGAGCCAAA
GAGCAAGTCAGGTCACATTTCTCTGCAGCAATATCATTCATTTTGAAAGTTTACGAACAAGAACTGCAGAAGCCTTAAACCTGGATGCGG
CGTTATTTGAACTAATCAAGCGATGTCAGCAGATGTGTTCGTTTGCATCACAGTTTAACAGTTCAGTGTCTGAGTTAGAGCTTCGTTTAT
TACAGAGAGTGGACACTGGTCTTGAACATCCTATTGGCAGCTCTGAATGGCTTTTGTCAGCACACAAACAGTTGACCCAGGATATGTCTA
CTCAGAGGGCAATTCAGACAGAGAAAGAGCAGCAGATAGAAACGGTCTGTGAAACAATTCAGAATCTGGTTGATAATATAAAGACTGTGC
TCACTGGTCATAACCGACAGCTTGGAGATGTCAAACATCTCTTGAAAGCTATGGCTAAGGATGAAGAAGCTGCTCTGGCAGATGGTGAAG
ATGTTCCCTATGAGAACAGTGTTAGGCAGTTTTTGGGTGAATATAAATCATGGCAAGACAACATTCAAACAGTTCTATTTACATTAGTCC
AGGCTATGGGTCAGGTTCGAAGTCAAGAACACGTTGAAATGCTCCAGGAAATCACTCCCACCTTGAAAGAACTGAAAACACAAAGTCAGA
GTATCTATAATAATTTAGTGAGTTTTGCATCACCCTTAGTCACCGATGCAACAAATGAATGTTCGAGTCCAACGTCATCTGCTACTTATC
AGCCATCCTTCGCTGCAGCAGTCCGGAGTAACACTGGCCAGAAGACTCAGCCTGATGTCATGTCACAGAATGCTAGAAAGCTGATCCAAA
AAAATCTTGCTACATCAGCTGATACTCCACCAAGCACCGTTCCAGGAACTGGCAAGAGTGTTGCTTGTAGTCCTAAAAAGGCAGTCAGAG
ACCCTAAAACTGGGAAAGCGGTGCAAGAGAGAAACTCCTATGCAGTGAGTGTGTGGAAGAGAGTGAAAGCCAAGTTAGAGGGCCGAGATG
TTGATCCGAATAGGAGGATGTCAGTTGCTGAACAGGTTGACTATGTCATTAAGGAAGCAACTAATCTAGATAACTTGGCTCAGCTGTATG
AAGGTTGGACAGCCTGGGTGTGAATGGCAAGACAGTAGATGAGTCTGGTTAAGCGAGGTCAGACATCCACCAGAATCAACTCAGCCTCAG
GCATCCAAAGCCACACCACAGTCGGTGGTGATGCAACTGGGGGCTTACTCTGAGGAAACCTAGGAAATCTCGGTGCACTAGGAAGTGAAT
CCCGCAGGACAGCTGCACTCAGGGATACGCCCAACACCATGGCCTGCAACCCCAGGGTCAAGGGTGAAGGAAAGCAAGCTCACCGCCTGA
ACACGGAGATTGTCTTTCTGCCACAGAACAGCAGCAGACGTGTCGGGAGGTTAGCTGCGGAAAGAAATCGGGATGCCGCGGAGCACAGAG
TGATTTGGAACTCCATTCCACCTGACCCTGTGTGTACAATCCAGGAAAAAAACAAACCCCACTCAGAAACAGAGAAAACTGGGGTCGCGA
AGAAATCACAGCCAAGGAAGATTTGATGCATTCAGATTCTCGTGTAACACTTGTTGCTTGGCAACAGTACTGGTTGGGTTGACCAGTAAG
TAGAAAAAGGCTAAAGGCTATGCGATATGAATTTCAGAAATGGACTGAAAATGGAGAGCTATGTAACAGATACACTACAGTAGAAGAACT
TACTTCTGAAATGAAGGGAAAAAAACCACCCCATCGTTCCCTACTCCTCCCCACCACTTACCCGTTCCCCCTTTACCTAATCTAGTAGAT
TAGCCATCTTTCAAATTCACTTTTATTTCAGTCCTTATATTTCATATACTTCCGTCTCGATGCTGTTAACAACTTCTGATAACATGGAAA
ATTCAAGGATTGTTTAAAGGTCTGATGATCACACACAAAATGTAATTCCGGTTATTTAAGTCATTTCTGTGATTCTATCATGTACAGTTT
CCAGAATTGTCACTGTGCATTCAAAAGTAATGAATCTAACAGACATTTGATTTAATGTACACTCCCTTTTGCTTATAGTGTGCATTTTTT
TTGGAGGTCATTCAAATTTTCCCTCTTCTGTGATAGCTGTAGTTTCTTTCATAGAAAGTAGCTAATCCAGTGTAATCTTTTACCTTTTTA
AAAACCAAGATAGAGTATCTATTAGAGTTTTACATTGTTGATGATAGATTAACAATAAAGTGATGTTCTGGTGGAGGTAGACTGAAATTT
TTTTAATTCATGTTTTTCATTTGATACTTTTAATTTACACTTAGTAAATTAAAAGTTGTTTAATTTACTTGGCATTTTAGGACATGTACA
TGAAACAGTGAAAATGAGATCCACCAACATCTTTTATTAAGTTCAGTTATTAGTCTGTGAAGTGCTTTACTTTTTGCACAATTTTAATAG
CTTGCTATTCAGTAATACATTATAGTGAATTCATGATCAAGGTTTCCTTAAATTTAGCATTGCATTTCAGTACTGACTGTGTAAGCTAAA
TTGCTGATCCAAAATAAAAACCCAGACTAGAATAGGGTTCTTAAAATCAAGTATCAATACAAAATAGAACACAATTAAAATCTTAATTGT
TGGCTGGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCATGAGGTTAGGAGAGCGAGACCATCCT
GGCTAACACGGTGAAACCCCGTCTTTACTAAAAATACAAAAAAAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGG
AGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAG
CTAGACTCTGTGTCAAAAATAAATGACTAGATAAAAAAAAAAATTGTTTGAGTACATTTTCCCTGCATTTTAGAGATTAGGACAGTGGTC
ACTTTCTAGTTGCCGTCTTCACAGACAAACTTGAAAGGTATTAAGGAAAAAATTCCACATAGCTCTGGGCCTTTTTTGTATTCTGATTGC
CACGTTAATCTGTAATCGTTAAGTACCCATGAAAGAATGTGTTTCAGTATCAGTGCTTTTTTGGTACTTTAACAAGTATTGTAGGCACGG
TGGATTTTTTTGAAATACCCATGTGTCCAATAGCAAGTTAAGGAACCTAGCGCATCAAATTTTGTTTTCTTCATTCATTTGGAACCTTAT
TTTCGCAAAAAACCTAGCTGGAATAATAATGCCATATTGTATTTTGCACACTGCTTTATTTTCTAGAGGCTCTGGGAGCAAATTACATTC
ATCACATTACCTCTGCTCTCTCAAGATTAAAGTCTTTCAGCAACATTCTTTATTGTCATCATAAGGAAAAACTTTTATCGCAATGATAGT
CAGTTCACATTAGTTTAGCACTATAGATAGTATTCAGAAATTGCTTTCTCTTTGGTAAAGAAGATAAATAGGTGAATTTTATTGCCTGTG
TTTTCAGGCTTCAGAGGTACCTGGCACCTTACTCAAGCAAAAACAAAAAACAGCTTTACTTCAAAAGCATGTGCCTCTGGTAAATTATCC
ATCACTTTTGTTTTAAAGTGGTCCCTCCAAGAATAATGTGGCATACACAGTGGGTTTGGTTGTAAGGCAGATGTAATAGATGACTTCAAA
AGCCTGCTCCTTACTGCACTCTGGACAAGGCCCTGGTCTGTATAGTTTGGCTTCCTCTGTTAAGTCATTCTACAAGGTGACTTGCCATTT
GAACTTTCGTAAGAGACCTCAGCAGTTAGACTGAGAAAAGTTAGAGTGCTGTAGTTATGAAGTCATACATTTTTGATAAAATACCTGTGG
AAAACCAGGGATCCTCTCCTGTTTCTCTCTCTTGCCTCCCCCTTTCCCTCCATTCCTCTGTCGCCTCCCCCTCTCCTCCACTTTCTTTAA
GAATCAGGGGGTACAGAATAACCTACAAACAACCTCTTCAAAGTACCCTTGGAAATTGAAGTTCAATCTTAAGTTTTTTGCTGTCTTTAA
TTTACTAGAATTGCCTAATTTTTAGTTGATTTCTCTACAGAGCTTAGCTTGTGTAGTTATTTCTCTTTTACTGTTGCTTTGGTGTGTCTT
GAAGTTTGATTGATTATTTTTGGTCATTGAGTTCTTAGTGTAGTTTGCTAGATGATTATTAAGATTCTTTTGTGTCTGACACTTGTGGTG
AGTTGCTTTTGAAATCTGTTGAGATTTCCATGTGAGAACTGATAATCAGGCTCTTGATCTGCTTCCCTAAATTACTTTTTTAGAGCCCAA
ACCCCAGGTTTAGGGTGAGGGTTTGTAATACAAAGAAACACTTCCATCACTTCTGCCCTTAACCCTTGCCTCTATTACCTAAGCTTAGTA
AGTAGTTTTCTTAATATTGTCCAATGTTTGGTGTTATCTGCATTGTTTTTTGTTTTTTTAATTGTGGTTGTTCTGACGTGTGAAATTTAA
GGAAAGAGCCATTTTTTAAAAATGCCGAGCAGGGCAATGCAAGTACAGCCAAATATTAGACTTGATGTGCAATCTTCGGTCCTTTTTAAT
CTGGGGTATTATAGGCAGTACTTTAAATTGCAAAGTCTTCCGGGCCTATTTTCCTCTACATTTTTGTAATTAACTCTGGGGGCTTACTTG
TTTTGGCAGTACTGAAATCAAAGGAGCTGGTTCTTCTTTTCTCCCAATTATTTTCATATGAAAGCACCTACAATTAGCCTGTTAGTCCTA
TTCAGATACATCAAATATCAGTGAATGCTTTACTATTCGCACATTTAAGCATCTTTGTTTTACATAAAATTAGAGTATGAAAACCAGTGT
TCAATTTTTTATCTTGTTGAGCTTGTAAAATGCCAGCAATTTAAAACTAGGACTTTTCCCCCCATAAGCCAAGGAGGTAGAATTACTAAT
ACAAGGGTTAAAGAAGGTAGATTTTGTTTTCAATATTTGGGTAATATTAGAAAGATTCTTCCCACAGGGAAGAACTAGCAAGTGTCCCAA
TTTTTTCCAAACGTTGGGGAGGGGAAAATTCACTGTATCATGAAACCCTAAGGGTTTGTTGCACTTCCTGCTTTTTAGGCCTGGATAACA
GTATCACCATCCTTATTTACAGAAGGGTAAAACTGACTCTTAATGAGAAAAGCTTTATAAGTTCAAGGGCTGTAAAATATGAACTACTTA
GGGTCGTTTGCCTTCCATGGGAACTTGGCTAGACTTAGAAAAAGCTGTTTGTTGTGCTAATGTAAAAGTGTCATACAATTTAGAAGATTT
TTGAAGATGGTAAACTTAGAAGAATTCTATGTTCTGAAATGCACACTTTTAGAATGTTTTTCTTTGAAAACAGGCTAATAGTTTTTTCTT
TTTTTGACAAAGTTTCAGCTCCTCTTTAAAGTTATTGTGTCATTTTTCTGGTTTAAATTTCCCTTATATTTCCACCTGTAATGTCAGTGG
CAACAACATCATACTTCACTTACTTGTTAATTTACTTTTTACCCTTATTCTAAGAGCAAGTTGAGTTGAACTGAATCTTCCTTGTCTTAG
TAACAATGTATAAATAGTGGCTTTTCTGTACAAAAGGTTGTAATGCCTCCTGATGGATATAATTTTGTGATTGTATTTAAAAGTTGAATA
AATCACACCAGCTTCCTGAAAATGTTCATAATGCATCTTTTGGAAAACAAATACATGCCTACTTTGTGCATATTTGCATTAACATGGCAA

>62793_62793_5_PARN-SMG1_PARN_chr16_14645878_ENST00000539279_SMG1_chr16_18849788_ENST00000389467_length(amino acids)=1636AA_BP=335
MRRARARVGPRFRPLCRMEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKKERYIVISKVDEEE
RKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDII
NNTSLAELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVM
DIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVKIGKSLRVPEKVPFRMTQNIETALGVT
GVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGFAGAVYGGGGQQAESKQSKREMEREITRSLFSSRVAEIKVNWFK
NRDEMLVVLPKLDGSLDEYLSLQEQLTDVEKLQGKLLEEIEFLEGAEGVDHPSHTLQHRYSEHTQLQTQQRAVQEAIQVKLNEFEQWITH
YQAAFNNLEATQLASLLQEISTQMDLGPPSYVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQLHHYATVALQYPKAIF
QKHRIEQWKTWMEELICNTTVERCQELYRKYEMQYAPQPPPTVCQFITATEMTLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIE
RCIKVFLHENGEEGSLSLASVIISALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTCLVQLLKQCHLVPQDLDIPN
PMEASETVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGEYTLESMLHELDGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHY
IDVARLLHAQYGELIQPRNGSVDETPKMSAGQMLLVAFDGMFAQVETAFSLLVEKLNKMEIPIAWRKIDIIREARSTQVNFFDDDNHRQV
LEEIFFLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQIVNVKTLFRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTL
CSFISALGVDIIAQVEAKDFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMNRATVLASSYDTAWKKHDLVRRLETSISSCKTSLQRVQLH
IAMFQQWQHEDLLINRPQAMSVTPPPRSAILTSMKKKLHTLSQIETSIATVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAER
RNLVLKESQRASQVTFLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSELELRLLQRVDTGLEHPIGSSEWLLSA
HKQLTQDMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVKHLLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDN
IQTVLFTLVQAMGQVRSQEHVEMLQEITPTLKELKTQSQSIYNNLVSFASPLVTDATNECSSPTSSATYQPSFAAAVRSNTGQKTQPDVM
SQNARKLIQKNLATSADTPPSTVPGTGKSVACSPKKAVRDPKTGKAVQERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEAT

--------------------------------------------------------------
>62793_62793_6_PARN-SMG1_PARN_chr16_14645878_ENST00000539279_SMG1_chr16_18849788_ENST00000446231_length(transcript)=9686nt_BP=1068nt
GTCACCGCTGCGGCTGCCTCAGCTACTGCCGCAGTCGCCGCGGAATTCGGCGAGTAGAACCGCTGAGGCGGGCGCGGGCCCGGGTGGGGC
CAAGGTTCCGGCCACTCTGCAGAATGGAGATAATCAGGAGCAATTTTAAGAGTAATCTTCACAAAGTGTACCAGGCCATAGAGGAGGCCG
ACTTCTTCGCCATCGATGGGGAGTTTTCAGGAATCAGTGATGGACCTTCAGTCTCTGCATTAACAAATGGTTTTGACACTCCAGAAGAGA
GGTATCAGAAGCTTAAAAAGAAGGAGCGATATATAGTTATCAGCAAAGTAGATGAAGAAGAACGCAAAAGAAGAGAGCAGCAGAAACATG
CCAAAGAACAGGAGGAGCTGAATGATGCTGTGGGATTTTCTAGAGTCATTCACGCCATTGCTAATTCGGGAAAACTTGTTATTGGACACA
ATATGCTCTTGGACGTCATGCACACAGTTCATCAGTTCTACTGCCCTCTGCCTGCGGACTTAAGTGAGTTTAAAGAGATGACAACATGTG
TTTTCCCCAGACTCTTGGATACTAAATTGATGGCCAGCACACAACCTTTTAAGGATATCATTAACAACACATCCCTTGCGGAATTGGAAA
AGCGGTTAAAAGAGACACCTTTCAACCCTCCTAAAGTTGAAAGTGCCGAAGGTTTTCCAAGTTATGACACAGCCTCTGAACAACTCCACG
AGGCAGGCTACGATGCCTACATCACAGGGCTGTGCTTCATCTCCATGGCCAATTACCTAGGTTCTTTTCTCAGCCCTCCAAAAATTCATG
TGTCTGCCAGATCAAAACTCATTGAACCTTTTTTTAACAAGTTATTTCTTATGAGGGTCATGGATATCCCCTATCTAAACTTGGAAGGAC
CAGACTTGCAGCCTAAACGTGATCATGTTCTCCATGTGACATTCCCCAAAGAATGGAAAACCAGCGACCTTTACCAGCTTTTCAGTGCCT
TTGGTAACATTCAGATATCCTGGATTGATGACACATCAGCATTTGTTTCCCTTAGCCAGCCCGAGCAAGTAAAGATTGGTAAAAGCCTTA
GAGTTCCTGAGAAAGTACCTTTTCGAATGACACAAAACATTGAAACAGCACTGGGTGTAACTGGAGTAGAAGGTGTATTTAGGCTTTCAT
GTGAGCAGGTTTTACACATTATGCGGCGTGGCAGAGAGACCCTGCTGACGCTGCTGGAGGCCTTTGTGTACGACCCTCTGGTGGACTGGA
CAGCAGGAGGCGAGGCTGGGTTTGCTGGTGCTGTCTATGGTGGAGGTGGCCAGCAGGCCGAGAGCAAGCAGAGCAAGAGAGAGATGGAGC
GAGAGATCACCCGCAGCCTGTTTTCTTCTAGAGTAGCTGAGATTAAGGTGAACTGGTTTAAGAATAGAGATGAGATGCTGGTTGTGCTTC
CCAAGTTGGACGGTAGCTTAGATGAATACCTAAGCTTGCAAGAGCAACTGACAGATGTGGAAAAACTGCAGGGCAAACTACTGGAGGAAA
TAGAGTTTCTAGAAGGAGCTGAAGGGGTGGATCATCCTTCTCATACTCTGCAACACAGGTATTCTGAGCACACCCAACTACAGACTCAGC
AAAGAGCTGTTCAGGAAGCAATCCAGGTGAAGCTGAATGAATTTGAACAATGGATAACACATTATCAGGCTGCATTCAATAATTTAGAAG
CAACACAGCTTGCAAGCTTGCTTCAAGAGATAAGCACACAAATGGACCTTGGTCCTCCAAGTTACGTGCCAGCAACAGCCTTTCTGCAGA
ATGCTGGTCAGGCCCACTTGATTAGCCAGTGCGAGCAGCTGGAGGGGGAGGTTGGTGCTCTCCTGCAGCAGAGGCGCTCCGTGCTCCGTG
GCTGTCTGGAGCAACTGCATCACTATGCAACCGTGGCCCTGCAGTATCCGAAGGCCATATTTCAGAAACATCGAATTGAACAGTGGAAGA
CCTGGATGGAAGAGCTCATCTGTAACACCACAGTAGAGCGTTGTCAAGAGCTCTATAGGAAATATGAAATGCAATATGCTCCCCAGCCAC
CCCCAACAGTGTGTCAGTTCATCACTGCCACTGAAATGACCCTGCAGCGATACGCAGCAGACATCAACAGCAGACTTATTAGACAAGTGG
AACGCTTGAAACAGGAAGCTGTCACTGTGCCAGTTTGTGAAGATCAGTTGAAAGAAATTGAACGTTGCATTAAAGTTTTCCTTCATGAGA
ATGGAGAAGAAGGATCTTTGAGTCTAGCAAGTGTTATTATTTCTGCCCTTTGTACCCTTACAAGGCGTAACCTGATGATGGAAGGTGCAG
CGTCAAGTGCTGGAGAACAGCTGGTTGATCTGACTTCTCGGGATGGAGCCTGGTTCTTGGAGGAACTCTGCAGTATGAGCGGAAACGTCA
CCTGCTTGGTTCAGTTACTGAAGCAGTGCCACCTGGTGCCACAGGACTTAGATATCCCGAACCCCATGGAAGCGTCTGAGACAGTTCACT
TAGCCAATGGAGTGTATACCTCACTTCAGGAATTGAATTCGAATTTCCGGCAAATCATATTTCCAGAAGCACTTCGATGTTTAATGAAAG
GGGAATACACGTTAGAAAGTATGCTGCATGAACTGGACGGTCTTATTGAGCAGACCACCGATGGCGTTCCCCTGCAGACTCTAGTGGAAT
CTCTTCAGGCCTACTTAAGAAACGCAGCTATGGGACTGGAAGAAGAAACACATGCTCATTACATCGATGTTGCCAGACTACTACATGCTC
AGTACGGTGAATTAATCCAACCGAGAAATGGTTCAGTTGATGAAACACCCAAAATGTCAGCTGGCCAGATGCTTTTGGTAGCATTCGATG
GCATGTTTGCTCAAGTTGAAACTGCTTTCAGCTTATTAGTTGAAAAGTTGAACAAGATGGAAATTCCCATAGCTTGGCGAAAGATTGACA
TCATAAGGGAAGCCAGGAGTACTCAAGTTAATTTTTTTGATGATGATAATCACCGGCAGGTGCTAGAAGAGATTTTCTTTCTAAAAAGAC
TACAGACTATTAAGGAGTTCTTCAGGCTCTGTGGTACCTTTTCTAAAACATTGTCAGGATCAAGTTCACTTGAAGATCAGAATACTGTGA
ATGGGCCTGTACAGATTGTCAATGTGAAAACCCTTTTTAGAAACTCTTGTTTCAGTGAAGACCAAATGGCCAAACCTATCAAGGCATTCA
CAGCTGACTTTGTGAGGCAGCTCTTGATAGGGCTACCCAACCAAGCCCTCGGACTCACACTGTGCAGTTTTATCAGTGCTCTGGGTGTAG
ACATCATTGCTCAAGTAGAGGCAAAGGACTTTGGTGCCGAAAGCAAAGTTTCTGTTGATGATCTCTGTAAGAAAGCGGTGGAACATAACA
TCCAGATAGGGAAGTTCTCTCAGCTGGTTATGAACAGGGCAACTGTGTTAGCAAGTTCTTACGACACTGCCTGGAAGAAGCATGACTTGG
TGCGAAGGCTAGAAACCAGTATTTCTTCTTGTAAGACAAGCCTGCAGCGGGTTCAGCTGCATATTGCCATGTTTCAGTGGCAACATGAAG
ATCTACTTATCAATAGACCACAAGCCATGTCAGTCACACCTCCCCCACGGTCTGCTATCCTAACCAGCATGAAAAAGAAGCTGCATACCC
TGAGCCAGATTGAAACTTCTATTGCAACAGTTCAGGAGAAGCTAGCTGCACTTGAATCAAGTATTGAACAGCGACTCAAGTGGGCAGGTG
GTGCCAACCCTGCATTGGCCCCTGTACTACAAGATTTTGAAGCAACGATAGCTGAAAGAAGAAATCTTGTCCTTAAAGAGAGCCAAAGAG
CAAGTCAGGTCACATTTCTCTGCAGCAATATCATTCATTTTGAAAGTTTACGAACAAGAACTGCAGAAGCCTTAAACCTGGATGCGGCGT
TATTTGAACTAATCAAGCGATGTCAGCAGATGTGTTCGTTTGCATCACAGTTTAACAGTTCAGTGTCTGAGTTAGAGCTTCGTTTATTAC
AGAGAGTGGACACTGGTCTTGAACATCCTATTGGCAGCTCTGAATGGCTTTTGTCAGCACACAAACAGTTGACCCAGGATATGTCTACTC
AGAGGGCAATTCAGACAGAGAAAGAGCAGCAGATAGAAACGGTCTGTGAAACAATTCAGAATCTGGTTGATAATATAAAGACTGTGCTCA
CTGGTCATAACCGACAGCTTGGAGATGTCAAACATCTCTTGAAAGCTATGGCTAAGGATGAAGAAGCTGCTCTGGCAGATGGTGAAGATG
TTCCCTATGAGAACAGTGTTAGGCAGTTTTTGGGTGAATATAAATCATGGCAAGACAACATTCAAACAGTTCTATTTACATTAGTCCAGG
CTATGGGTCAGGTTCGAAGTCAAGAACACGTTGAAATGCTCCAGGAAATCACTCCCACCTTGAAAGAACTGAAAACACAAAGTCAGAGTA
TCTATAATAATTTAGTGAGTTTTGCATCACCCTTAGTCACCGATGCAACAAATGAATGTTCGAGTCCAACGTCATCTGCTACTTATCAGC
CATCCTTCGCTGCAGCAGTCCGGAGTAACACTGGCCAGAAGACTCAGCCTGATGTCATGTCACAGAATGCTAGAAAGCTGATCCAAAAAA
ATCTTGCTACATCAGCTGATACTCCACCAAGCACCGTTCCAGGAACTGGCAAGAGTGTTGCTTGTAGTCCTAAAAAGGCAGTCAGAGACC
CTAAAACTGGGAAAGCGGTGCAAGAGAGAAACTCCTATGCAGTGAGTGTGTGGAAGAGAGTGAAAGCCAAGTTAGAGGGCCGAGATGTTG
ATCCGAATAGGAGGATGTCAGTTGCTGAACAGGTTGACTATGTCATTAAGGAAGCAACTAATCTAGATAACTTGGCTCAGCTGTATGAAG
GTTGGACAGCCTGGGTGTGAATGGCAAGACAGTAGATGAGTCTGGTTAAGCGAGGTCAGACATCCACCAGAATCAACTCAGCCTCAGGCA
TCCAAAGCCACACCACAGTCGGTGGTGATGCAACTGGGGGCTTACTCTGAGGAAACCTAGGAAATCTCGGTGCACTAGGAAGTGAATCCC
GCAGGACAGCTGCACTCAGGGATACGCCCAACACCATGGCCTGCAACCCCAGGGTCAAGGGTGAAGGAAAGCAAGCTCACCGCCTGAACA
CGGAGATTGTCTTTCTGCCACAGAACAGCAGCAGACGTGTCGGGAGGTTAGCTGCGGAAAGAAATCGGGATGCCGCGGAGCACAGAGTGA
TTTGGAACTCCATTCCACCTGACCCTGTGTGTACAATCCAGGAAAAAAACAAACCCCACTCAGAAACAGAGAAAACTGGGGTCGCGAAGA
AATCACAGCCAAGGAAGATTTGATGCATTCAGATTCTCGTGTAACACTTGTTGCTTGGCAACAGTACTGGTTGGGTTGACCAGTAAGTAG
AAAAAGGCTAAAGGCTATGCGATATGAATTTCAGAAATGGACTGAAAATGGAGAGCTATGTAACAGATACACTACAGTAGAAGAACTTAC
TTCTGAAATGAAGGGAAAAAAACCACCCCATCGTTCCCTACTCCTCCCCACCACTTACCCGTTCCCCCTTTACCTAATCTAGTAGATTAG
CCATCTTTCAAATTCACTTTTATTTCAGTCCTTATATTTCATATACTTCCGTCTCGATGCTGTTAACAACTTCTGATAACATGGAAAATT
CAAGGATTGTTTAAAGGTCTGATGATCACACACAAAATGTAATTCCGGTTATTTAAGTCATTTCTGTGATTCTATCATGTACAGTTTCCA
GAATTGTCACTGTGCATTCAAAAGTAATGAATCTAACAGACATTTGATTTAATGTACACTCCCTTTTGCTTATAGTGTGCATTTTTTTTG
GAGGTCATTCAAATTTTCCCTCTTCTGTGATAGCTGTAGTTTCTTTCATAGAAAGTAGCTAATCCAGTGTAATCTTTTACCTTTTTAAAA
ACCAAGATAGAGTATCTATTAGAGTTTTACATTGTTGATGATAGATTAACAATAAAGTGATGTTCTGGTGGAGGTAGACTGAAATTTTTT
TAATTCATGTTTTTCATTTGATACTTTTAATTTACACTTAGTAAATTAAAAGTTGTTTAATTTACTTGGCATTTTAGGACATGTACATGA
AACAGTGAAAATGAGATCCACCAACATCTTTTATTAAGTTCAGTTATTAGTCTGTGAAGTGCTTTACTTTTTGCACAATTTTAATAGCTT
GCTATTCAGTAATACATTATAGTGAATTCATGATCAAGGTTTCCTTAAATTTAGCATTGCATTTCAGTACTGACTGTGTAAGCTAAATTG
CTGATCCAAAATAAAAACCCAGACTAGAATAGGGTTCTTAAAATCAAGTATCAATACAAAATAGAACACAATTAAAATCTTAATTGTTGG
CTGGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCATGAGGTTAGGAGAGCGAGACCATCCTGGC
TAACACGGTGAAACCCCGTCTTTACTAAAAATACAAAAAAAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGG
CTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCTA
GACTCTGTGTCAAAAATAAATGACTAGATAAAAAAAAAAATTGTTTGAGTACATTTTCCCTGCATTTTAGAGATTAGGACAGTGGTCACT
TTCTAGTTGCCGTCTTCACAGACAAACTTGAAAGGTATTAAGGAAAAAATTCCACATAGCTCTGGGCCTTTTTTGTATTCTGATTGCCAC
GTTAATCTGTAATCGTTAAGTACCCATGAAAGAATGTGTTTCAGTATCAGTGCTTTTTTGGTACTTTAACAAGTATTGTAGGCACGGTGG
ATTTTTTTGAAATACCCATGTGTCCAATAGCAAGTTAAGGAACCTAGCGCATCAAATTTTGTTTTCTTCATTCATTTGGAACCTTATTTT
CGCAAAAAACCTAGCTGGAATAATAATGCCATATTGTATTTTGCACACTGCTTTATTTTCTAGAGGCTCTGGGAGCAAATTACATTCATC
ACATTACCTCTGCTCTCTCAAGATTAAAGTCTTTCAGCAACATTCTTTATTGTCATCATAAGGAAAAACTTTTATCGCAATGATAGTCAG
TTCACATTAGTTTAGCACTATAGATAGTATTCAGAAATTGCTTTCTCTTTGGTAAAGAAGATAAATAGGTGAATTTTATTGCCTGTGTTT
TCAGGCTTCAGAGGTACCTGGCACCTTACTCAAGCAAAAACAAAAAACAGCTTTACTTCAAAAGCATGTGCCTCTGGTAAATTATCCATC
ACTTTTGTTTTAAAGTGGTCCCTCCAAGAATAATGTGGCATACACAGTGGGTTTGGTTGTAAGGCAGATGTAATAGATGACTTCAAAAGC
CTGCTCCTTACTGCACTCTGGACAAGGCCCTGGTCTGTATAGTTTGGCTTCCTCTGTTAAGTCATTCTACAAGGTGACTTGCCATTTGAA
CTTTCGTAAGAGACCTCAGCAGTTAGACTGAGAAAAGTTAGAGTGCTGTAGTTATGAAGTCATACATTTTTGATAAAATACCTGTGGAAA
ACCAGGGATCCTCTCCTGTTTCTCTCTCTTGCCTCCCCCTTTCCCTCCATTCCTCTGTCGCCTCCCCCTCTCCTCCACTTTCTTTAAGAA
TCAGGGGGTACAGAATAACCTACAAACAACCTCTTCAAAGTACCCTTGGAAATTGAAGTTCAATCTTAAGTTTTTTGCTGTCTTTAATTT
ACTAGAATTGCCTAATTTTTAGTTGATTTCTCTACAGAGCTTAGCTTGTGTAGTTATTTCTCTTTTACTGTTGCTTTGGTGTGTCTTGAA
GTTTGATTGATTATTTTTGGTCATTGAGTTCTTAGTGTAGTTTGCTAGATGATTATTAAGATTCTTTTGTGTCTGACACTTGTGGTGAGT
TGCTTTTGAAATCTGTTGAGATTTCCATGTGAGAACTGATAATCAGGCTCTTGATCTGCTTCCCTAAATTACTTTTTTAGAGCCCAAACC
CCAGGTTTAGGGTGAGGGTTTGTAATACAAAGAAACACTTCCATCACTTCTGCCCTTAACCCTTGCCTCTATTACCTAAGCTTAGTAAGT
AGTTTTCTTAATATTGTCCAATGTTTGGTGTTATCTGCATTGTTTTTTGTTTTTTTAATTGTGGTTGTTCTGACGTGTGAAATTTAAGGA
AAGAGCCATTTTTTAAAAATGCCGAGCAGGGCAATGCAAGTACAGCCAAATATTAGACTTGATGTGCAATCTTCGGTCCTTTTTAATCTG
GGGTATTATAGGCAGTACTTTAAATTGCAAAGTCTTCCGGGCCTATTTTCCTCTACATTTTTGTAATTAACTCTGGGGGCTTACTTGTTT
TGGCAGTACTGAAATCAAAGGAGCTGGTTCTTCTTTTCTCCCAATTATTTTCATATGAAAGCACCTACAATTAGCCTGTTAGTCCTATTC
AGATACATCAAATATCAGTGAATGCTTTACTATTCGCACATTTAAGCATCTTTGTTTTACATAAAATTAGAGTATGAAAACCAGTGTTCA
ATTTTTTATCTTGTTGAGCTTGTAAAATGCCAGCAATTTAAAACTAGGACTTTTCCCCCCATAAGCCAAGGAGGTAGAATTACTAATACA
AGGGTTAAAGAAGGTAGATTTTGTTTTCAATATTTGGGTAATATTAGAAAGATTCTTCCCACAGGGAAGAACTAGCAAGTGTCCCAATTT
TTTCCAAACGTTGGGGAGGGGAAAATTCACTGTATCATGAAACCCTAAGGGTTTGTTGCACTTCCTGCTTTTTAGGCCTGGATAACAGTA
TCACCATCCTTATTTACAGAAGGGTAAAACTGACTCTTAATGAGAAAAGCTTTATAAGTTCAAGGGCTGTAAAATATGAACTACTTAGGG
TCGTTTGCCTTCCATGGGAACTTGGCTAGACTTAGAAAAAGCTGTTTGTTGTGCTAATGTAAAAGTGTCATACAATTTAGAAGATTTTTG
AAGATGGTAAACTTAGAAGAATTCTATGTTCTGAAATGCACACTTTTAGAATGTTTTTCTTTGAAAACAGGCTAATAGTTTTTTCTTTTT
TTGACAAAGTTTCAGCTCCTCTTTAAAGTTATTGTGTCATTTTTCTGGTTTAAATTTCCCTTATATTTCCACCTGTAATGTCAGTGGCAA
CAACATCATACTTCACTTACTTGTTAATTTACTTTTTACCCTTATTCTAAGAGCAAGTTGAGTTGAACTGAATCTTCCTTGTCTTAGTAA
CAATGTATAAATAGTGGCTTTTCTGTACAAAAGGTTGTAATGCCTCCTGATGGATATAATTTTGTGATTGTATTTAAAAGTTGAATAAAT
CACACCAGCTTCCTGAAAATGTTCATAATGCATCTTTTGGAAAACAAATACATGCCTACTTTGTGCATATTTGCATTAACATGGCAAAGA

>62793_62793_6_PARN-SMG1_PARN_chr16_14645878_ENST00000539279_SMG1_chr16_18849788_ENST00000446231_length(amino acids)=1635AA_BP=335
MRRARARVGPRFRPLCRMEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKKERYIVISKVDEEE
RKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDII
NNTSLAELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVM
DIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVKIGKSLRVPEKVPFRMTQNIETALGVT
GVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGFAGAVYGGGGQQAESKQSKREMEREITRSLFSSRVAEIKVNWFK
NRDEMLVVLPKLDGSLDEYLSLQEQLTDVEKLQGKLLEEIEFLEGAEGVDHPSHTLQHRYSEHTQLQTQQRAVQEAIQVKLNEFEQWITH
YQAAFNNLEATQLASLLQEISTQMDLGPPSYVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQLHHYATVALQYPKAIF
QKHRIEQWKTWMEELICNTTVERCQELYRKYEMQYAPQPPPTVCQFITATEMTLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIE
RCIKVFLHENGEEGSLSLASVIISALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTCLVQLLKQCHLVPQDLDIPN
PMEASETVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGEYTLESMLHELDGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHY
IDVARLLHAQYGELIQPRNGSVDETPKMSAGQMLLVAFDGMFAQVETAFSLLVEKLNKMEIPIAWRKIDIIREARSTQVNFFDDDNHRQV
LEEIFFLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQIVNVKTLFRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTL
CSFISALGVDIIAQVEAKDFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMNRATVLASSYDTAWKKHDLVRRLETSISSCKTSLQRVQLH
IAMFQWQHEDLLINRPQAMSVTPPPRSAILTSMKKKLHTLSQIETSIATVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERR
NLVLKESQRASQVTFLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSELELRLLQRVDTGLEHPIGSSEWLLSAH
KQLTQDMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVKHLLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDNI
QTVLFTLVQAMGQVRSQEHVEMLQEITPTLKELKTQSQSIYNNLVSFASPLVTDATNECSSPTSSATYQPSFAAAVRSNTGQKTQPDVMS
QNARKLIQKNLATSADTPPSTVPGTGKSVACSPKKAVRDPKTGKAVQERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATN

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Top

Fusion Gene PPI Analysis for PARN-SMG1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	SMG1	chr16:14645878	chr16:18849788	ENST00000446231		42	63	1_1977	2361.3333333333335	3662.0	SMG8 and SMG9

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PARN-SMG1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PARN-SMG1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source