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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PARP1-LIN9 (FusionGDB2 ID:62822)

Fusion Gene Summary for PARP1-LIN9

Fusion gene summary

Fusion gene information	Fusion gene name: PARP1-LIN9
	Fusion gene ID: 62822
		Hgene	Tgene
	Gene symbol	PARP1	LIN9
	Gene ID	142	286826
	Gene name	poly(ADP-ribose) polymerase 1	lin-9 DREAM MuvB core complex component
	Synonyms	ADPRT\|ADPRT 1\|ADPRT1\|ARTD1\|PARP\|PARP-1\|PPOL\|pADPRT-1	BARA\|BARPsv\|Lin-9\|TGS\|TGS1\|TGS2
	Cytomap	1q42.12	1q42.12
	Type of gene	protein-coding	protein-coding
	Description	poly [ADP-ribose] polymerase 1ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)ADP-ribosyltransferase NAD(+)ADP-ribosyltransferase diphtheria toxin-like 1DNA ADP-ribosyltransferase PARP1NAD(+) ADP-ribosyltransferase 1poly (ADP-ribose) poly	protein lin-9 homologTUDOR gene similar proteinbeta subunit-associated regulator of apoptosislin-9 homologpRB-associated proteinrb related pathway actortype I interferon receptor beta chain-associated protein
	Modification date	20200329	20200313
	UniProtAcc	.	Q5TKA1
	Ensembl transtripts involved in fusion gene	ENST00000366794, ENST00000366790, ENST00000366791, ENST00000366792, ENST00000490921,	ENST00000328205, ENST00000366801, ENST00000481685,
Fusion gene scores	* DoF score	4 X 4 X 2=32	6 X 4 X 5=120
	# samples	4	7
	** MAII score	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PARP1 [Title/Abstract] AND LIN9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PARP1(226561927)-LIN9(226438620), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PARP1	GO:0006471	protein ADP-ribosylation	7852410\|17396150\|26344098\|27067600
Hgene	PARP1	GO:0006915	apoptotic process	15565177
Hgene	PARP1	GO:0018312	peptidyl-serine ADP-ribosylation	28190768
Hgene	PARP1	GO:0018424	peptidyl-glutamic acid poly-ADP-ribosylation	19764761
Hgene	PARP1	GO:0030592	DNA ADP-ribosylation	27471034
Hgene	PARP1	GO:0032869	cellular response to insulin stimulus	19303849
Hgene	PARP1	GO:0045944	positive regulation of transcription by RNA polymerase II	11112786
Hgene	PARP1	GO:0050790	regulation of catalytic activity	25749521
Hgene	PARP1	GO:0070212	protein poly-ADP-ribosylation	15674325\|19470756\|25043379
Hgene	PARP1	GO:0070213	protein auto-ADP-ribosylation	19764761
Hgene	PARP1	GO:1905168	positive regulation of double-strand break repair via homologous recombination	26344098\|30356214
Hgene	PARP1	GO:1990966	ATP generation from poly-ADP-D-ribose	27257257

Fusion gene breakpoints across PARP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LIN9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CQ-5332-01A	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
ChimerDB4	HNSC	TCGA-CQ-5332	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-

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Fusion Gene ORF analysis for PARP1-LIN9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000366794	ENST00000328205	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
In-frame	ENST00000366794	ENST00000366801	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
In-frame	ENST00000366794	ENST00000481685	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
intron-3CDS	ENST00000366790	ENST00000328205	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
intron-3CDS	ENST00000366790	ENST00000366801	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
intron-3CDS	ENST00000366790	ENST00000481685	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
intron-3CDS	ENST00000366791	ENST00000328205	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
intron-3CDS	ENST00000366791	ENST00000366801	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
intron-3CDS	ENST00000366791	ENST00000481685	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
intron-3CDS	ENST00000366792	ENST00000328205	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
intron-3CDS	ENST00000366792	ENST00000366801	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
intron-3CDS	ENST00000366792	ENST00000481685	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
intron-3CDS	ENST00000490921	ENST00000328205	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
intron-3CDS	ENST00000490921	ENST00000366801	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-
intron-3CDS	ENST00000490921	ENST00000481685	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000366794	PARP1	chr1	226561927	-	ENST00000328205	LIN9	chr1	226438620	-	4149	2214	144	2804	886
ENST00000366794	PARP1	chr1	226561927	-	ENST00000366801	LIN9	chr1	226438620	-	4142	2214	144	2804	886
ENST00000366794	PARP1	chr1	226561927	-	ENST00000481685	LIN9	chr1	226438620	-	3082	2214	144	2702	852

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000366794	ENST00000328205	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-	0.000531293	0.99946874
ENST00000366794	ENST00000366801	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-	0.000530681	0.99946934
ENST00000366794	ENST00000481685	PARP1	chr1	226561927	-	LIN9	chr1	226438620	-	0.003627148	0.99637294

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Fusion Genomic Features for PARP1-LIN9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PARP1-LIN9

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:226561927/chr1:226438620)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	LIN9 Q5TKA1
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269\|PubMed:15538385, ECO:0000269\|PubMed:16730350}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PARP1

chr1:226561927

chr1:226438620

ENST00000366794

385_476

690

1015.0

Domain

BRCT

Hgene

PARP1

chr1:226561927

chr1:226438620

ENST00000366794

554_630

690

1015.0

Domain

WGR

Hgene

PARP1

chr1:226561927

chr1:226438620

ENST00000366794

207_209

690

1015.0

Motif

Nuclear localization signal

Hgene

PARP1

chr1:226561927

chr1:226438620

ENST00000366794

221_226

690

1015.0

Motif

Nuclear localization signal

Hgene

PARP1

chr1:226561927

chr1:226438620

ENST00000366794

198_233

690

1015.0

Region

Disordered

Hgene

PARP1

chr1:226561927

chr1:226438620

ENST00000366794

355_386

690

1015.0

Region

Disordered

Hgene

PARP1

chr1:226561927

chr1:226438620

ENST00000366794

373_524

690

1015.0

Region

Automodification domain

Hgene

PARP1

chr1:226561927

chr1:226438620

ENST00000366794

113_203

690

1015.0

Zinc finger

PARP-type 2

Hgene

PARP1

chr1:226561927

chr1:226438620

ENST00000366794

9_93

690

1015.0

Zinc finger

PARP-type 1

Tgene

LIN9

chr1:226561927

chr1:226438620

ENST00000366801

354_413

311

508.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PARP1

chr1:226561927

chr1:226438620

ENST00000366794

662_779

690

1015.0

Domain

PARP alpha-helical

Hgene

PARP1

chr1:226561927

chr1:226438620

ENST00000366794

788_1014

690

1015.0

Domain

PARP catalytic

Hgene

PARP1

chr1:226561927

chr1:226438620

ENST00000366794

862_864

690

1015.0

Nucleotide binding

NAD

Tgene

LIN9

chr1:226561927

chr1:226438620

ENST00000328205

354_413

362

559.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for PARP1-LIN9

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>62822_62822_1_PARP1-LIN9_PARP1_chr1_226561927_ENST00000366794_LIN9_chr1_226438620_ENST00000328205_length(transcript)=4149nt_BP=2214nt
CGGTGGCCGGTGCGGCGTGTTCGGTGGCGGCTCTGGCCGCTCAGGCGCCTGCGGCTGGGTGAGCGCACGCGAGGCGGCGAGGCGGCAGCG
TGTTTCTAGGTCGTGGCGTCGGGCTTCCGGAGCTTTGGCGGCAGCTAGGGGAGGATGGCGGAGTCTTCGGATAAGCTCTATCGAGTCGAG
TACGCCAAGAGCGGGCGCGCCTCTTGCAAGAAATGCAGCGAGAGCATCCCCAAGGACTCGCTCCGGATGGCCATCATGGTGCAGTCGCCC
ATGTTTGATGGAAAAGTCCCACACTGGTACCACTTCTCCTGCTTCTGGAAGGTGGGCCACTCCATCCGGCACCCTGACGTTGAGGTGGAT
GGGTTCTCTGAGCTTCGGTGGGATGACCAGCAGAAAGTCAAGAAGACAGCGGAAGCTGGAGGAGTGACAGGCAAAGGCCAGGATGGAATT
GGTAGCAAGGCAGAGAAGACTCTGGGTGACTTTGCAGCAGAGTATGCCAAGTCCAACAGAAGTACGTGCAAGGGGTGTATGGAGAAGATA
GAAAAGGGCCAGGTGCGCCTGTCCAAGAAGATGGTGGACCCGGAGAAGCCACAGCTAGGCATGATTGACCGCTGGTACCATCCAGGCTGC
TTTGTCAAGAACAGGGAGGAGCTGGGTTTCCGGCCCGAGTACAGTGCGAGTCAGCTCAAGGGCTTCAGCCTCCTTGCTACAGAGGATAAA
GAAGCCCTGAAGAAGCAGCTCCCAGGAGTCAAGAGTGAAGGAAAGAGAAAAGGCGATGAGGTGGATGGAGTGGATGAAGTGGCGAAGAAG
AAATCTAAAAAAGAAAAAGACAAGGATAGTAAGCTTGAAAAAGCCCTAAAGGCTCAGAACGACCTGATCTGGAACATCAAGGACGAGCTA
AAGAAAGTGTGTTCAACTAATGACCTGAAGGAGCTACTCATCTTCAACAAGCAGCAAGTGCCTTCTGGGGAGTCGGCGATCTTGGACCGA
GTAGCTGATGGCATGGTGTTCGGTGCCCTCCTTCCCTGCGAGGAATGCTCGGGTCAGCTGGTCTTCAAGAGCGATGCCTATTACTGCACT
GGGGACGTCACTGCCTGGACCAAGTGTATGGTCAAGACACAGACACCCAACCGGAAGGAGTGGGTAACCCCAAAGGAATTCCGAGAAATC
TCTTACCTCAAGAAATTGAAGGTTAAAAAACAGGACCGTATATTCCCCCCAGAAACCAGCGCCTCCGTGGCGGCCACGCCTCCGCCCTCC
ACAGCCTCGGCTCCTGCTGCTGTGAACTCCTCTGCTTCAGCAGATAAGCCATTATCCAACATGAAGATCCTGACTCTCGGGAAGCTGTCC
CGGAACAAGGATGAAGTGAAGGCCATGATTGAGAAACTCGGGGGGAAGTTGACGGGGACGGCCAACAAGGCTTCCCTGTGCATCAGCACC
AAAAAGGAGGTGGAAAAGATGAATAAGAAGATGGAGGAAGTAAAGGAAGCCAACATCCGAGTTGTGTCTGAGGACTTCCTCCAGGACGTC
TCCGCCTCCACCAAGAGCCTTCAGGAGTTGTTCTTAGCGCACATCTTGTCCCCTTGGGGGGCAGAGGTGAAGGCAGAGCCTGTTGAAGTT
GTGGCCCCAAGAGGGAAGTCAGGGGCTGCGCTCTCCAAAAAAAGCAAGGGCCAGGTCAAGGAGGAAGGTATCAACAAATCTGAAAAGAGA
ATGAAATTAACTCTTAAAGGAGGAGCAGCTGTGGATCCTGATTCTGGACTGGAACACTCTGCGCATGTCCTGGAGAAAGGTGGGAAGGTC
TTCAGTGCCACCCTTGGCCTGGTGGACATCGTTAAAGGAACCAACTCCTACTACAAGCTGCAGCTTCTGGAGGACGACAAGGAAAACAGG
TATTGGATATTCAGGTCCTGGGGCCGTGTGGGTACGGTGATCGGTAGCAACAAACTGGAACAGATGCCGTCCAAGGAGGATGCCATTGAG
CACTTCATGAAATTATATGAAGAAAAAACCGGGAACGCTTGGCACTCCAAAAATTTCACGAAGTATCCCAAAAAGTTCTACCCCCTGGAG
ATTGACTATGGCCAGGATGAAGAGGCAGTGAAGAAGCTGACAGTAAATCCTGGCACCAAGTCCAAGCTCCCCAAGCCAGTTCAGGACCTC
ATCAAGATGATCTTTGATGTGGAAAGTATGAAGAAAGCCATGGTGGAGTATGAGACCAGATTATCAAAAATTCTCATGATTAAAAAGGAA
CATATCAAGAAATTAAGGGAAATGAACACAGAAGCAGAAAAATTGAAATCATATTCCATGCCCATCAGCATTGAATTTCAGCGGAGATAT
GCAACAATTGTTCTGGAGCTTGAACAGCTGAACAAGGACCTAAACAAAGTTTTGCATAAAGTTCAACAGTATTGCTATGAGCTTGCTCCA
GACCAGGGGCTCCAGCCTGCAGATCAGCCAACAGATATGAGACGCAGGTGTGAGGAAGAAGCACAGGAAATTGTTCGGCATGCAAATTCC
TCAACAGGACAGCCCTGCGTTGAAAATGAAAATCTGACAGACTTAATTTCCAGGCTTACAGCTATTTTGTTACAAATTAAGTGTCTAGCA
GAAGGAGGAGACCTGAATTCCTTTGAATTCAAATCACTTACAGACTCATTAAATGATATCAAGAGTACAATAGACGCTTCTAATATCAGT
TGCTTTCAGAATAATGTAGAAATCCATGTTGCACATATTCAGAGTGGCCTGAGCCAGATGGGAAACTTACATGCCTTTGCAGCAAATAAC
ACCAACAGAGACTGAGTAAAGATTTCATTATTCCAACTGCACGGGACATTGTTTTTGAGAAGTTCTTTTCCTTTATATAGGCTTCCAACA
CCAAATAACCTAACTGCTGGAAAACAAGGGAAATTTAAATCTCCAAATAAGGCATTTTAATAGACTGTACTGCTTCTTAAACCAGCATTG
CTGACCAGCATTATATTTATTTTTCTTTTATTATTCAGATGCAGTAGCATTGCTTATGTTACATATGTTTATATTCACAAATATTTTTAA
ACTGAAATATCTGAACATAATATAATTTCGTGGAAGAATACATTGACCATTTTTTTTAATGTGCATGAATTCACCGCAACACATGCAGAC
AACTGCTGCAATGGAGAGTATGAAGAAACCTGGTCTTTTTATTCATGTCGGTGGCAGTGTGGAAATTCCATCCAGAAAATTACAACTCCA
CTTGATTTAGTTGATCACCATCTCAGTCTTCAAAAGATAACATCATGAGGTGTGGGAAGTCCTAGTTTTAAGGAAACCACTGAAATATAG
ATGGGAAATGTGGACTTTACAAGTATATGTTATATATACTTGCAATGTGACATGGTTCTGTAGATCATTTTATAATAATAAATATTTTAA
TTTATCATAACATATAAAAGAAACCTTTGTTGTTTGTTGAAAGAAAATGAAGGAACAGGGGGAAAAAAGGTGCAAAATGCTAAATTTCTA
AAAATGGATTTGGCATGTCTTCCCATCAGTTCAGGTCAAAAGTGCATTGTTGTGAGATTTATTAAAAAAAAAATGATAACACACTATTTT
CATATTTTTTTGTTTATTTGCACAACTTTTAAACCAGATTACTGGTTAAAATCCAACAGTACACAATTTATAAAGTAAAAAGATTTTATA
AGGAAAACAAATATAATAACCAGTGCTGTGAAATGCAGAAGAAAGGCTTGTTTTGGTTGTTTTTCTTTTTTAGGAAAACGCTGCCTAAAA
TGTTAATCTTGTAAAAAGTATGTATTTGGAATTTTCTTCGTTTTAATAGAATATTATAAACTCAAAATATAAATTTTTTTCAAATTTGGA
GTTTAAGATATAGCTGTAGAGGTGGTTTTAATTCCTTTAGATGTCTCATAAAATGAGACTTTTTATATGTTAATGTATAATAAAACTGAA
ACAAGATTATTTTCCATTTGAAATTTTTGTATAGTTTAAAAAGGCTTCCGTATTCTTTGTTGGTATTGTGCCACTGCAGAACTTTAGTGC
AGAGTTTATATTTAGCTAAACTGTTATGTTAATTAAGAAATGCATAAATCTTCTATTCTTAATATTTGTAATTCTAAATAAATTGATCTA

>62822_62822_1_PARP1-LIN9_PARP1_chr1_226561927_ENST00000366794_LIN9_chr1_226438620_ENST00000328205_length(amino acids)=886AA_BP=0
MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAE
AGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ
LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQ
QVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE
TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEAN
IRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE
HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKN
FTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYETRLSKILMIKKEHIKKLREMNTEAEKLKSY
SMPISIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISR

--------------------------------------------------------------
>62822_62822_2_PARP1-LIN9_PARP1_chr1_226561927_ENST00000366794_LIN9_chr1_226438620_ENST00000366801_length(transcript)=4142nt_BP=2214nt
CGGTGGCCGGTGCGGCGTGTTCGGTGGCGGCTCTGGCCGCTCAGGCGCCTGCGGCTGGGTGAGCGCACGCGAGGCGGCGAGGCGGCAGCG
TGTTTCTAGGTCGTGGCGTCGGGCTTCCGGAGCTTTGGCGGCAGCTAGGGGAGGATGGCGGAGTCTTCGGATAAGCTCTATCGAGTCGAG
TACGCCAAGAGCGGGCGCGCCTCTTGCAAGAAATGCAGCGAGAGCATCCCCAAGGACTCGCTCCGGATGGCCATCATGGTGCAGTCGCCC
ATGTTTGATGGAAAAGTCCCACACTGGTACCACTTCTCCTGCTTCTGGAAGGTGGGCCACTCCATCCGGCACCCTGACGTTGAGGTGGAT
GGGTTCTCTGAGCTTCGGTGGGATGACCAGCAGAAAGTCAAGAAGACAGCGGAAGCTGGAGGAGTGACAGGCAAAGGCCAGGATGGAATT
GGTAGCAAGGCAGAGAAGACTCTGGGTGACTTTGCAGCAGAGTATGCCAAGTCCAACAGAAGTACGTGCAAGGGGTGTATGGAGAAGATA
GAAAAGGGCCAGGTGCGCCTGTCCAAGAAGATGGTGGACCCGGAGAAGCCACAGCTAGGCATGATTGACCGCTGGTACCATCCAGGCTGC
TTTGTCAAGAACAGGGAGGAGCTGGGTTTCCGGCCCGAGTACAGTGCGAGTCAGCTCAAGGGCTTCAGCCTCCTTGCTACAGAGGATAAA
GAAGCCCTGAAGAAGCAGCTCCCAGGAGTCAAGAGTGAAGGAAAGAGAAAAGGCGATGAGGTGGATGGAGTGGATGAAGTGGCGAAGAAG
AAATCTAAAAAAGAAAAAGACAAGGATAGTAAGCTTGAAAAAGCCCTAAAGGCTCAGAACGACCTGATCTGGAACATCAAGGACGAGCTA
AAGAAAGTGTGTTCAACTAATGACCTGAAGGAGCTACTCATCTTCAACAAGCAGCAAGTGCCTTCTGGGGAGTCGGCGATCTTGGACCGA
GTAGCTGATGGCATGGTGTTCGGTGCCCTCCTTCCCTGCGAGGAATGCTCGGGTCAGCTGGTCTTCAAGAGCGATGCCTATTACTGCACT
GGGGACGTCACTGCCTGGACCAAGTGTATGGTCAAGACACAGACACCCAACCGGAAGGAGTGGGTAACCCCAAAGGAATTCCGAGAAATC
TCTTACCTCAAGAAATTGAAGGTTAAAAAACAGGACCGTATATTCCCCCCAGAAACCAGCGCCTCCGTGGCGGCCACGCCTCCGCCCTCC
ACAGCCTCGGCTCCTGCTGCTGTGAACTCCTCTGCTTCAGCAGATAAGCCATTATCCAACATGAAGATCCTGACTCTCGGGAAGCTGTCC
CGGAACAAGGATGAAGTGAAGGCCATGATTGAGAAACTCGGGGGGAAGTTGACGGGGACGGCCAACAAGGCTTCCCTGTGCATCAGCACC
AAAAAGGAGGTGGAAAAGATGAATAAGAAGATGGAGGAAGTAAAGGAAGCCAACATCCGAGTTGTGTCTGAGGACTTCCTCCAGGACGTC
TCCGCCTCCACCAAGAGCCTTCAGGAGTTGTTCTTAGCGCACATCTTGTCCCCTTGGGGGGCAGAGGTGAAGGCAGAGCCTGTTGAAGTT
GTGGCCCCAAGAGGGAAGTCAGGGGCTGCGCTCTCCAAAAAAAGCAAGGGCCAGGTCAAGGAGGAAGGTATCAACAAATCTGAAAAGAGA
ATGAAATTAACTCTTAAAGGAGGAGCAGCTGTGGATCCTGATTCTGGACTGGAACACTCTGCGCATGTCCTGGAGAAAGGTGGGAAGGTC
TTCAGTGCCACCCTTGGCCTGGTGGACATCGTTAAAGGAACCAACTCCTACTACAAGCTGCAGCTTCTGGAGGACGACAAGGAAAACAGG
TATTGGATATTCAGGTCCTGGGGCCGTGTGGGTACGGTGATCGGTAGCAACAAACTGGAACAGATGCCGTCCAAGGAGGATGCCATTGAG
CACTTCATGAAATTATATGAAGAAAAAACCGGGAACGCTTGGCACTCCAAAAATTTCACGAAGTATCCCAAAAAGTTCTACCCCCTGGAG
ATTGACTATGGCCAGGATGAAGAGGCAGTGAAGAAGCTGACAGTAAATCCTGGCACCAAGTCCAAGCTCCCCAAGCCAGTTCAGGACCTC
ATCAAGATGATCTTTGATGTGGAAAGTATGAAGAAAGCCATGGTGGAGTATGAGACCAGATTATCAAAAATTCTCATGATTAAAAAGGAA
CATATCAAGAAATTAAGGGAAATGAACACAGAAGCAGAAAAATTGAAATCATATTCCATGCCCATCAGCATTGAATTTCAGCGGAGATAT
GCAACAATTGTTCTGGAGCTTGAACAGCTGAACAAGGACCTAAACAAAGTTTTGCATAAAGTTCAACAGTATTGCTATGAGCTTGCTCCA
GACCAGGGGCTCCAGCCTGCAGATCAGCCAACAGATATGAGACGCAGGTGTGAGGAAGAAGCACAGGAAATTGTTCGGCATGCAAATTCC
TCAACAGGACAGCCCTGCGTTGAAAATGAAAATCTGACAGACTTAATTTCCAGGCTTACAGCTATTTTGTTACAAATTAAGTGTCTAGCA
GAAGGAGGAGACCTGAATTCCTTTGAATTCAAATCACTTACAGACTCATTAAATGATATCAAGAGTACAATAGACGCTTCTAATATCAGT
TGCTTTCAGAATAATGTAGAAATCCATGTTGCACATATTCAGAGTGGCCTGAGCCAGATGGGAAACTTACATGCCTTTGCAGCAAATAAC
ACCAACAGAGACTGAGTAAAGATTTCATTATTCCAACTGCACGGGACATTGTTTTTGAGAAGTTCTTTTCCTTTATATAGGCTTCCAACA
CCAAATAACCTAACTGCTGGAAAACAAGGGAAATTTAAATCTCCAAATAAGGCATTTTAATAGACTGTACTGCTTCTTAAACCAGCATTG
CTGACCAGCATTATATTTATTTTTCTTTTATTATTCAGATGCAGTAGCATTGCTTATGTTACATATGTTTATATTCACAAATATTTTTAA
ACTGAAATATCTGAACATAATATAATTTCGTGGAAGAATACATTGACCATTTTTTTTAATGTGCATGAATTCACCGCAACACATGCAGAC
AACTGCTGCAATGGAGAGTATGAAGAAACCTGGTCTTTTTATTCATGTCGGTGGCAGTGTGGAAATTCCATCCAGAAAATTACAACTCCA
CTTGATTTAGTTGATCACCATCTCAGTCTTCAAAAGATAACATCATGAGGTGTGGGAAGTCCTAGTTTTAAGGAAACCACTGAAATATAG
ATGGGAAATGTGGACTTTACAAGTATATGTTATATATACTTGCAATGTGACATGGTTCTGTAGATCATTTTATAATAATAAATATTTTAA
TTTATCATAACATATAAAAGAAACCTTTGTTGTTTGTTGAAAGAAAATGAAGGAACAGGGGGAAAAAAGGTGCAAAATGCTAAATTTCTA
AAAATGGATTTGGCATGTCTTCCCATCAGTTCAGGTCAAAAGTGCATTGTTGTGAGATTTATTAAAAAAAAAATGATAACACACTATTTT
CATATTTTTTTGTTTATTTGCACAACTTTTAAACCAGATTACTGGTTAAAATCCAACAGTACACAATTTATAAAGTAAAAAGATTTTATA
AGGAAAACAAATATAATAACCAGTGCTGTGAAATGCAGAAGAAAGGCTTGTTTTGGTTGTTTTTCTTTTTTAGGAAAACGCTGCCTAAAA
TGTTAATCTTGTAAAAAGTATGTATTTGGAATTTTCTTCGTTTTAATAGAATATTATAAACTCAAAATATAAATTTTTTTCAAATTTGGA
GTTTAAGATATAGCTGTAGAGGTGGTTTTAATTCCTTTAGATGTCTCATAAAATGAGACTTTTTATATGTTAATGTATAATAAAACTGAA
ACAAGATTATTTTCCATTTGAAATTTTTGTATAGTTTAAAAAGGCTTCCGTATTCTTTGTTGGTATTGTGCCACTGCAGAACTTTAGTGC
AGAGTTTATATTTAGCTAAACTGTTATGTTAATTAAGAAATGCATAAATCTTCTATTCTTAATATTTGTAATTCTAAATAAATTGATCTA

>62822_62822_2_PARP1-LIN9_PARP1_chr1_226561927_ENST00000366794_LIN9_chr1_226438620_ENST00000366801_length(amino acids)=886AA_BP=0
MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAE
AGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ
LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQ
QVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE
TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEAN
IRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE
HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKN
FTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYETRLSKILMIKKEHIKKLREMNTEAEKLKSY
SMPISIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISR

--------------------------------------------------------------
>62822_62822_3_PARP1-LIN9_PARP1_chr1_226561927_ENST00000366794_LIN9_chr1_226438620_ENST00000481685_length(transcript)=3082nt_BP=2214nt
CGGTGGCCGGTGCGGCGTGTTCGGTGGCGGCTCTGGCCGCTCAGGCGCCTGCGGCTGGGTGAGCGCACGCGAGGCGGCGAGGCGGCAGCG
TGTTTCTAGGTCGTGGCGTCGGGCTTCCGGAGCTTTGGCGGCAGCTAGGGGAGGATGGCGGAGTCTTCGGATAAGCTCTATCGAGTCGAG
TACGCCAAGAGCGGGCGCGCCTCTTGCAAGAAATGCAGCGAGAGCATCCCCAAGGACTCGCTCCGGATGGCCATCATGGTGCAGTCGCCC
ATGTTTGATGGAAAAGTCCCACACTGGTACCACTTCTCCTGCTTCTGGAAGGTGGGCCACTCCATCCGGCACCCTGACGTTGAGGTGGAT
GGGTTCTCTGAGCTTCGGTGGGATGACCAGCAGAAAGTCAAGAAGACAGCGGAAGCTGGAGGAGTGACAGGCAAAGGCCAGGATGGAATT
GGTAGCAAGGCAGAGAAGACTCTGGGTGACTTTGCAGCAGAGTATGCCAAGTCCAACAGAAGTACGTGCAAGGGGTGTATGGAGAAGATA
GAAAAGGGCCAGGTGCGCCTGTCCAAGAAGATGGTGGACCCGGAGAAGCCACAGCTAGGCATGATTGACCGCTGGTACCATCCAGGCTGC
TTTGTCAAGAACAGGGAGGAGCTGGGTTTCCGGCCCGAGTACAGTGCGAGTCAGCTCAAGGGCTTCAGCCTCCTTGCTACAGAGGATAAA
GAAGCCCTGAAGAAGCAGCTCCCAGGAGTCAAGAGTGAAGGAAAGAGAAAAGGCGATGAGGTGGATGGAGTGGATGAAGTGGCGAAGAAG
AAATCTAAAAAAGAAAAAGACAAGGATAGTAAGCTTGAAAAAGCCCTAAAGGCTCAGAACGACCTGATCTGGAACATCAAGGACGAGCTA
AAGAAAGTGTGTTCAACTAATGACCTGAAGGAGCTACTCATCTTCAACAAGCAGCAAGTGCCTTCTGGGGAGTCGGCGATCTTGGACCGA
GTAGCTGATGGCATGGTGTTCGGTGCCCTCCTTCCCTGCGAGGAATGCTCGGGTCAGCTGGTCTTCAAGAGCGATGCCTATTACTGCACT
GGGGACGTCACTGCCTGGACCAAGTGTATGGTCAAGACACAGACACCCAACCGGAAGGAGTGGGTAACCCCAAAGGAATTCCGAGAAATC
TCTTACCTCAAGAAATTGAAGGTTAAAAAACAGGACCGTATATTCCCCCCAGAAACCAGCGCCTCCGTGGCGGCCACGCCTCCGCCCTCC
ACAGCCTCGGCTCCTGCTGCTGTGAACTCCTCTGCTTCAGCAGATAAGCCATTATCCAACATGAAGATCCTGACTCTCGGGAAGCTGTCC
CGGAACAAGGATGAAGTGAAGGCCATGATTGAGAAACTCGGGGGGAAGTTGACGGGGACGGCCAACAAGGCTTCCCTGTGCATCAGCACC
AAAAAGGAGGTGGAAAAGATGAATAAGAAGATGGAGGAAGTAAAGGAAGCCAACATCCGAGTTGTGTCTGAGGACTTCCTCCAGGACGTC
TCCGCCTCCACCAAGAGCCTTCAGGAGTTGTTCTTAGCGCACATCTTGTCCCCTTGGGGGGCAGAGGTGAAGGCAGAGCCTGTTGAAGTT
GTGGCCCCAAGAGGGAAGTCAGGGGCTGCGCTCTCCAAAAAAAGCAAGGGCCAGGTCAAGGAGGAAGGTATCAACAAATCTGAAAAGAGA
ATGAAATTAACTCTTAAAGGAGGAGCAGCTGTGGATCCTGATTCTGGACTGGAACACTCTGCGCATGTCCTGGAGAAAGGTGGGAAGGTC
TTCAGTGCCACCCTTGGCCTGGTGGACATCGTTAAAGGAACCAACTCCTACTACAAGCTGCAGCTTCTGGAGGACGACAAGGAAAACAGG
TATTGGATATTCAGGTCCTGGGGCCGTGTGGGTACGGTGATCGGTAGCAACAAACTGGAACAGATGCCGTCCAAGGAGGATGCCATTGAG
CACTTCATGAAATTATATGAAGAAAAAACCGGGAACGCTTGGCACTCCAAAAATTTCACGAAGTATCCCAAAAAGTTCTACCCCCTGGAG
ATTGACTATGGCCAGGATGAAGAGGCAGTGAAGAAGCTGACAGTAAATCCTGGCACCAAGTCCAAGCTCCCCAAGCCAGTTCAGGACCTC
ATCAAGATGATCTTTGATGTGGAAAGTATGAAGAAAGCCATGGTGGAGTATGAGACCAGATTATCAAAAATTCTCATGATTAAAAAGGAA
CATATCAAGAAATTAAGGGAAATGAACACAGAAGCAGAAAAATTGAAATCATATTCCATGCCCATCAGCATTGAATTTCAGCGGAGATAT
GCAACAATTGTTCTGGAGCTTGAACAGCTGAACAAGGACCTAAACAAAGTTTTGCATAAAGTTCAACAGTATTGCTATGAGCTTGCTCCA
GACCAGGGGCTCCAGCCTGCAGATCAGCCAACAGATATGAGACGCAGGTGTGAGGAAGAAGCACAGGAAATTGTTCGGCATGCAAATTCC
TCAACAGGACAGCCCTGCGTTGAAAATGAAAATCTGACAGACTTAATTTCCAGGCTTACAGCTATTTTGTTACAAATTAAGTGTCTAGCA
GAAGGAGGAGACCTGAATTCCTTTGAATTCAAATCACTTACAGACTCATTAAATGATATCAAGAGTACAATAGACGCTTCTAATATCAGG
TAATTCGTTAGGTATACTCTAATCATTTTAATGTGAAGTTCATAGTAATTTTCAGTCCAGGTTTTAAGAATTATGCATATTTGTGAAGTA
CTCATATATTATTATCCGTTAAATATATTTGTAAGAGCTTTTCACTTATATCCAGCCTATGGACAGAATAGAAATTTCACATGGATTTTG
TATATAAAGAAATCAGGACATATATTTAGGTTTGGGGTCAGCATGGAGGTTGAGCTTAGAGGTAGAGCTTCCCCAGTCAGTGAGAGACTC
ATCTTCTCCTTCCAGCCCCCCGTGGCTCCTTTGCTTCTTTAGAGCATATTTGTTCAACTACTACTGAAGTAGAATTATGGCTAATATATT

>62822_62822_3_PARP1-LIN9_PARP1_chr1_226561927_ENST00000366794_LIN9_chr1_226438620_ENST00000481685_length(amino acids)=852AA_BP=0
MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAE
AGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ
LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQ
QVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE
TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEAN
IRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE
HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKN
FTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYETRLSKILMIKKEHIKKLREMNTEAEKLKSY
SMPISIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PARP1-LIN9

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PARP1-LIN9

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PARP1-LIN9

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source