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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PARP8-CCDC91 (FusionGDB2 ID:62844)

Fusion Gene Summary for PARP8-CCDC91

check button Fusion gene summary
Fusion gene informationFusion gene name: PARP8-CCDC91
Fusion gene ID: 62844
HgeneTgene
Gene symbol

PARP8

CCDC91

Gene ID

79668

55297

Gene namepoly(ADP-ribose) polymerase family member 8coiled-coil domain containing 91
SynonymsARTD16|pART16HSD8|p56
Cytomap

5q11.1

12p11.22

Type of geneprotein-codingprotein-coding
Descriptionprotein mono-ADP-ribosyltransferase PARP8ADP-ribosyltransferase diphtheria toxin-like 16coiled-coil domain-containing protein 91GGA-binding partnerp56 accessory protein
Modification date2020031320200313
UniProtAcc.

Q7Z6B0

Ensembl transtripts involved in fusion geneENST00000511363, ENST00000281631, 
ENST00000503665, ENST00000503750, 
ENST00000505554, ENST00000505697, 
ENST00000513738, ENST00000514067, 
ENST00000514342, 		ENST00000381256, 
ENST00000381259, ENST00000539107, 
ENST00000545336, ENST00000306172, 
ENST00000540401, 
Fusion gene scores* DoF score13 X 11 X 9=128715 X 14 X 9=1890
# samples 1517
** MAII scorelog2(15/1287*10)=-3.10097764772482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1890*10)=-3.47477958297073
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PARP8 [Title/Abstract] AND CCDC91 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPARP8(49963959)-CCDC91(28603093), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePARP8

GO:0070213

protein auto-ADP-ribosylation

25043379


check buttonFusion gene breakpoints across PARP8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCDC91 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A4QSPARP8chr5

49963959

+CCDC91chr12

28603093

+


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Fusion Gene ORF analysis for PARP8-CCDC91

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000511363ENST00000381256PARP8chr5

49963959

+CCDC91chr12

28603093

+
3UTR-3CDSENST00000511363ENST00000381259PARP8chr5

49963959

+CCDC91chr12

28603093

+
3UTR-3CDSENST00000511363ENST00000539107PARP8chr5

49963959

+CCDC91chr12

28603093

+
3UTR-3CDSENST00000511363ENST00000545336PARP8chr5

49963959

+CCDC91chr12

28603093

+
3UTR-3UTRENST00000511363ENST00000306172PARP8chr5

49963959

+CCDC91chr12

28603093

+
3UTR-3UTRENST00000511363ENST00000540401PARP8chr5

49963959

+CCDC91chr12

28603093

+
5CDS-3UTRENST00000281631ENST00000306172PARP8chr5

49963959

+CCDC91chr12

28603093

+
5CDS-3UTRENST00000281631ENST00000540401PARP8chr5

49963959

+CCDC91chr12

28603093

+
5CDS-3UTRENST00000503665ENST00000306172PARP8chr5

49963959

+CCDC91chr12

28603093

+
5CDS-3UTRENST00000503665ENST00000540401PARP8chr5

49963959

+CCDC91chr12

28603093

+
5CDS-3UTRENST00000503750ENST00000306172PARP8chr5

49963959

+CCDC91chr12

28603093

+
5CDS-3UTRENST00000503750ENST00000540401PARP8chr5

49963959

+CCDC91chr12

28603093

+
5CDS-3UTRENST00000505554ENST00000306172PARP8chr5

49963959

+CCDC91chr12

28603093

+
5CDS-3UTRENST00000505554ENST00000540401PARP8chr5

49963959

+CCDC91chr12

28603093

+
5CDS-3UTRENST00000505697ENST00000306172PARP8chr5

49963959

+CCDC91chr12

28603093

+
5CDS-3UTRENST00000505697ENST00000540401PARP8chr5

49963959

+CCDC91chr12

28603093

+
5CDS-3UTRENST00000513738ENST00000306172PARP8chr5

49963959

+CCDC91chr12

28603093

+
5CDS-3UTRENST00000513738ENST00000540401PARP8chr5

49963959

+CCDC91chr12

28603093

+
5CDS-3UTRENST00000514067ENST00000306172PARP8chr5

49963959

+CCDC91chr12

28603093

+
5CDS-3UTRENST00000514067ENST00000540401PARP8chr5

49963959

+CCDC91chr12

28603093

+
5UTR-3CDSENST00000514342ENST00000381256PARP8chr5

49963959

+CCDC91chr12

28603093

+
5UTR-3CDSENST00000514342ENST00000381259PARP8chr5

49963959

+CCDC91chr12

28603093

+
5UTR-3CDSENST00000514342ENST00000539107PARP8chr5

49963959

+CCDC91chr12

28603093

+
5UTR-3CDSENST00000514342ENST00000545336PARP8chr5

49963959

+CCDC91chr12

28603093

+
5UTR-3UTRENST00000514342ENST00000306172PARP8chr5

49963959

+CCDC91chr12

28603093

+
5UTR-3UTRENST00000514342ENST00000540401PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000281631ENST00000381256PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000281631ENST00000381259PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000281631ENST00000539107PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000281631ENST00000545336PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000503665ENST00000381256PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000503665ENST00000381259PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000503665ENST00000539107PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000503665ENST00000545336PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000503750ENST00000381256PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000503750ENST00000381259PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000503750ENST00000539107PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000503750ENST00000545336PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000505554ENST00000381256PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000505554ENST00000381259PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000505554ENST00000539107PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000505554ENST00000545336PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000505697ENST00000381256PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000505697ENST00000381259PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000505697ENST00000539107PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000505697ENST00000545336PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000513738ENST00000381256PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000513738ENST00000381259PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000513738ENST00000539107PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000513738ENST00000545336PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000514067ENST00000381256PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000514067ENST00000381259PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000514067ENST00000539107PARP8chr5

49963959

+CCDC91chr12

28603093

+
Frame-shiftENST00000514067ENST00000545336PARP8chr5

49963959

+CCDC91chr12

28603093

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PARP8-CCDC91


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PARP8chr549963959+CCDC91chr1228603093+0.0121892510.98781073
PARP8chr549963959+CCDC91chr1228603093+0.0121892510.98781073

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PARP8-CCDC91


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:49963959/:28603093)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCDC91

Q7Z6B0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. {ECO:0000269|PubMed:17596511}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PARP8-CCDC91


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PARP8-CCDC91


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PARP8-CCDC91


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PARP8-CCDC91


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource