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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PARVA-USP47 (FusionGDB2 ID:62883)

Fusion Gene Summary for PARVA-USP47

check button Fusion gene summary
Fusion gene informationFusion gene name: PARVA-USP47
Fusion gene ID: 62883
HgeneTgene
Gene symbol

PARVA

USP47

Gene ID

55742

55031

Gene nameparvin alphaubiquitin specific peptidase 47
SynonymsCH-ILKBP|MXRA2TRFP
Cytomap

11p15.3

11p15.3

Type of geneprotein-codingprotein-coding
Descriptionalpha-parvinactopaxincalponin-like integrin-linked kinase-binding proteinmatrix-remodeling-associated protein 2ubiquitin carboxyl-terminal hydrolase 47Trf (TATA binding protein-related factor)-proximal homologdeubiquitinating enzyme 47ubiquitin thioesterase 47ubiquitin thiolesterase 47ubiquitin-specific-processing protease 47
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000334956, ENST00000539723, 
ENST00000550549, ENST00000526746, 
ENST00000538608, 		ENST00000305481, 
ENST00000399455, ENST00000527733, 
ENST00000539466, ENST00000339865, 
Fusion gene scores* DoF score16 X 12 X 7=134411 X 14 X 4=616
# samples 1713
** MAII scorelog2(17/1344*10)=-2.98292648664106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/616*10)=-2.24441872766645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PARVA [Title/Abstract] AND USP47 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPARVA(12399330)-USP47(11974288), # samples:1
PARVA(12399330)-USP47(11970025), # samples:1
Anticipated loss of major functional domain due to fusion event.PARVA-USP47 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PARVA-USP47 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUSP47

GO:0035520

monoubiquitinated protein deubiquitination

21362556


check buttonFusion gene breakpoints across PARVA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across USP47 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HI-01APARVAchr11

12399330

-USP47chr11

11970025

+
ChimerDB4SARCTCGA-3B-A9HI-01APARVAchr11

12399330

+USP47chr11

11974288

+


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Fusion Gene ORF analysis for PARVA-USP47

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000334956ENST00000305481PARVAchr11

12399330

+USP47chr11

11974288

+
5CDS-3UTRENST00000539723ENST00000305481PARVAchr11

12399330

+USP47chr11

11974288

+
5CDS-3UTRENST00000550549ENST00000305481PARVAchr11

12399330

+USP47chr11

11974288

+
5CDS-5UTRENST00000334956ENST00000399455PARVAchr11

12399330

-USP47chr11

11970025

+
5CDS-5UTRENST00000334956ENST00000399455PARVAchr11

12399330

+USP47chr11

11974288

+
5CDS-5UTRENST00000334956ENST00000527733PARVAchr11

12399330

-USP47chr11

11970025

+
5CDS-5UTRENST00000334956ENST00000527733PARVAchr11

12399330

+USP47chr11

11974288

+
5CDS-5UTRENST00000334956ENST00000539466PARVAchr11

12399330

-USP47chr11

11970025

+
5CDS-5UTRENST00000334956ENST00000539466PARVAchr11

12399330

+USP47chr11

11974288

+
5CDS-5UTRENST00000539723ENST00000399455PARVAchr11

12399330

-USP47chr11

11970025

+
5CDS-5UTRENST00000539723ENST00000399455PARVAchr11

12399330

+USP47chr11

11974288

+
5CDS-5UTRENST00000539723ENST00000527733PARVAchr11

12399330

-USP47chr11

11970025

+
5CDS-5UTRENST00000539723ENST00000527733PARVAchr11

12399330

+USP47chr11

11974288

+
5CDS-5UTRENST00000539723ENST00000539466PARVAchr11

12399330

-USP47chr11

11970025

+
5CDS-5UTRENST00000539723ENST00000539466PARVAchr11

12399330

+USP47chr11

11974288

+
5CDS-5UTRENST00000550549ENST00000399455PARVAchr11

12399330

-USP47chr11

11970025

+
5CDS-5UTRENST00000550549ENST00000399455PARVAchr11

12399330

+USP47chr11

11974288

+
5CDS-5UTRENST00000550549ENST00000527733PARVAchr11

12399330

-USP47chr11

11970025

+
5CDS-5UTRENST00000550549ENST00000527733PARVAchr11

12399330

+USP47chr11

11974288

+
5CDS-5UTRENST00000550549ENST00000539466PARVAchr11

12399330

-USP47chr11

11970025

+
5CDS-5UTRENST00000550549ENST00000539466PARVAchr11

12399330

+USP47chr11

11974288

+
5CDS-intronENST00000334956ENST00000305481PARVAchr11

12399330

-USP47chr11

11970025

+
5CDS-intronENST00000539723ENST00000305481PARVAchr11

12399330

-USP47chr11

11970025

+
5CDS-intronENST00000550549ENST00000305481PARVAchr11

12399330

-USP47chr11

11970025

+
Frame-shiftENST00000334956ENST00000339865PARVAchr11

12399330

-USP47chr11

11970025

+
Frame-shiftENST00000539723ENST00000339865PARVAchr11

12399330

-USP47chr11

11970025

+
Frame-shiftENST00000550549ENST00000339865PARVAchr11

12399330

-USP47chr11

11970025

+
In-frameENST00000334956ENST00000339865PARVAchr11

12399330

+USP47chr11

11974288

+
In-frameENST00000539723ENST00000339865PARVAchr11

12399330

+USP47chr11

11974288

+
In-frameENST00000550549ENST00000339865PARVAchr11

12399330

+USP47chr11

11974288

+
intron-3CDSENST00000526746ENST00000339865PARVAchr11

12399330

-USP47chr11

11970025

+
intron-3CDSENST00000526746ENST00000339865PARVAchr11

12399330

+USP47chr11

11974288

+
intron-3CDSENST00000538608ENST00000339865PARVAchr11

12399330

-USP47chr11

11970025

+
intron-3CDSENST00000538608ENST00000339865PARVAchr11

12399330

+USP47chr11

11974288

+
intron-3UTRENST00000526746ENST00000305481PARVAchr11

12399330

+USP47chr11

11974288

+
intron-3UTRENST00000538608ENST00000305481PARVAchr11

12399330

+USP47chr11

11974288

+
intron-5UTRENST00000526746ENST00000399455PARVAchr11

12399330

-USP47chr11

11970025

+
intron-5UTRENST00000526746ENST00000399455PARVAchr11

12399330

+USP47chr11

11974288

+
intron-5UTRENST00000526746ENST00000527733PARVAchr11

12399330

-USP47chr11

11970025

+
intron-5UTRENST00000526746ENST00000527733PARVAchr11

12399330

+USP47chr11

11974288

+
intron-5UTRENST00000526746ENST00000539466PARVAchr11

12399330

-USP47chr11

11970025

+
intron-5UTRENST00000526746ENST00000539466PARVAchr11

12399330

+USP47chr11

11974288

+
intron-5UTRENST00000538608ENST00000399455PARVAchr11

12399330

-USP47chr11

11970025

+
intron-5UTRENST00000538608ENST00000399455PARVAchr11

12399330

+USP47chr11

11974288

+
intron-5UTRENST00000538608ENST00000527733PARVAchr11

12399330

-USP47chr11

11970025

+
intron-5UTRENST00000538608ENST00000527733PARVAchr11

12399330

+USP47chr11

11974288

+
intron-5UTRENST00000538608ENST00000539466PARVAchr11

12399330

-USP47chr11

11970025

+
intron-5UTRENST00000538608ENST00000539466PARVAchr11

12399330

+USP47chr11

11974288

+
intron-intronENST00000526746ENST00000305481PARVAchr11

12399330

-USP47chr11

11970025

+
intron-intronENST00000538608ENST00000305481PARVAchr11

12399330

-USP47chr11

11970025

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334956PARVAchr1112399330+ENST00000339865USP47chr1111974288+4232599131083356
ENST00000539723PARVAchr1112399330+ENST00000339865USP47chr1111974288+385422125705226
ENST00000550549PARVAchr1112399330+ENST00000339865USP47chr1111974288+381818537669210

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334956ENST00000339865PARVAchr1112399330+USP47chr1111974288+0.0011303780.9988696
ENST00000539723ENST00000339865PARVAchr1112399330+USP47chr1111974288+0.0007223990.99927765
ENST00000550549ENST00000339865PARVAchr1112399330+USP47chr1111974288+0.0007327640.9992673

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Fusion Genomic Features for PARVA-USP47


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PARVAchr1112399330+USP47chr1111974287+0.005036570.9949634
PARVAchr1112399330+USP47chr1111974287+0.005036570.9949634

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PARVA-USP47


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:12399330/chr11:11974288)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUSP47chr11:12399330chr11:11974288ENST000005394662328188_5640158.0DomainNote=USP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARVAchr11:12399330chr11:11974288ENST00000550549+113262_36945373.0DomainCalponin-homology (CH) 2
HgenePARVAchr11:12399330chr11:11974288ENST00000550549+11395_20245373.0DomainCalponin-homology (CH) 1
TgeneUSP47chr11:12399330chr11:11974288ENST000003398652227188_56411261288.0DomainNote=USP
TgeneUSP47chr11:12399330chr11:11974288ENST000003994552429188_56412141376.0DomainNote=USP


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Fusion Gene Sequence for PARVA-USP47


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>62883_62883_1_PARVA-USP47_PARVA_chr11_12399330_ENST00000334956_USP47_chr11_11974288_ENST00000339865_length(transcript)=4232nt_BP=599nt
ACAGGCAGTAGTGCTGGGGCAGAGCGAGCTCACCAGCCGCCGGCTGGAAGACCCCGGGAGAGTAGCAGGGTTGGGTTGGTTCTCAGATGT
GTTTTGCGCCAGGCTGTGTGGTGGGGACAGAGCCTGGGTAAATGAAGCTTTCCGGCTCGACCGCTCCCAACCTGGGCACACACGTCCTCC
TGTCCTGCAAGGGGCAGTTTTGGGGCATCCTCCCTGCTTGGGGCAACCCAGGGGCGCAAGGCGCGGCCCCGGGAGCGCAGCTCCTTCCAG
GGCAGAGGGCGGCGCGAGGGAGGGAGCGAGGGAGGGAGCGAGGGAAGGGAAAGGCGAGCGTGAGCTGCCTCAAATGCTTGGAATAATTCC
GCTTCCGTTTGGAAAGCCGCAGCCTCAGTCCCGCCGCCGCCCGCTGCGTCCGCCCAGCGCCAGCTCCGCGTCCCGACCGGCCCGCGGCAG
CCTGCGCCGCGCCATGGCCACCTCCCCGCAGAAGTCGCCTTCTGTCCCCAAGTCTCCCACTCCCAAGTCGCCCCCGTCCCGCAAGAAAGA
TGATTCCTTCTTGGGGAAACTCGGAGGGACCCTGGCCCGGAGGAAGAAAGCCAAGGAGGGGGTAGAGAAGATGAAGTCCATGTCACAGCT
TGCAGTTTTGTCAAGACGGTGGAAGCCTTCAGAGATGAAGTTGGATCCCTTCCAGGAGGTTGTATTGGAAAGCAGTAGTGTGGACGAATT
GCGAGAGAAGCTTAGTGAAATCAGTGGGATTCCTTTGGATGATATTGAATTTGCTAAGGGTAGAGGAACATTTCCCTGTGATATTTCTGT
CCTTGATATTCATCAGGATTTAGACTGGAATCCTAAAGTTTCTACCCTGAATGTCTGGCCTCTTTATATCTGTGATGATGGTGCGGTCAT
ATTTTATAGGGATAAAACAGAAGAATTAATGGAATTGACAGATGAGCAAAGAAATGAACTGATGAAAAAAGAAAGCAGTCGACTCCAGAA
GACTGGACATCGTGTAACATACTCACCTCGTAAAGAGAAAGCACTAAAAATATATCTGGATGGAGCACCAAATAAAGATCTGACTCAAGA
CTGACTCTGATAGTGTAGCATTTTCCCTGGGGGAGTTTTGGTTTTAATTAGATGGTTCACTACCACTGGGTAGTGCCATTTTGGCCGGAC
ATGGTTGGGGTAACCCAGTGACACCAGCACTGATTGGACTGCCCTACACCAATCAGAAGCTCAGTGCCCAATGGGCCACTGTTTTGACTC
GGAATCATGTTGTGCACTATAGTCAAATGTACTGTAAAGTGAAAAGGGATGTGCAAAAAAATAAAAAAAAACAACAAAAAAAGCTAACCT
TCTATTAGAAAAGGGGACAGGGGAATGAGTAAACTTCTTTTATTGCGGACAAATGTGCACATAGCCGCTAGTAAAACTAGCCTCAAACAG
GATGCTCATAGCTTAATAATAAAAGCTGTGCAAAGGCCATGAATGAATGAATTTTCTGTTTATTTCACTGATGCACACATTACCTCATTG
ACAATTCAGAAGTAAATCCAACGTGTGTTGACTCTTGGAAAGCAGCAAAAACAGGAGCTGAAGAAAAGAAATTCTTGGAACCAGCCGTAA
CCCAGTAAGGAATTGTGAAGTTGTGTTTTTATTTTGTTTCATTTTTTGCAGAGTATTAAGAACATTATTCTGGAACATCAGAACGTTTCC
CTTAGACCGATCCCAGCAGGTGGCAGCTCAGATTGCTGCAGTGTTGTAATTATAACTGATTGTACTTAAGTTATGGATGTAGAGAATATG
TTTCATTCATTTATTCAGCATGTAAATAAAATTGATCCTGTTGAGTTATCATAATTGCAGTTCAACTATCTGCCATGATTATTCTTTTCA
CGTATCATTCATTCTGTACATTTGTGTACATTGAGAAGTATAGCAATCTATGTAAATGTAATCCTCAGTGAGGTTCCTCAGTGCTAGGTC
CCATAGGATTGTCGTTGCCCTTGTTAATGAGGTTTCTCTGTTCAGCGGCTTCAATTTTTTTCTCTTTGTACATCTAGTTTTGAAGATTTA
CTTCAAGTTTGAATCTTCTAGAATGCTTGTAAGTCCAGTTTTAATTTTTAGAGTCAATTTGTAGTTACATGTAGTTTAACTTTTGGGAAA
CGTCTTAACATTGTTCTGAATAAACTTGCTAATGAGGTCAGGTCATGGTACAGACTGATGCAGTCAACATGATTTCATTGCAGAGTTTAT
TAGTATCAGCAAGTTTTTGCTTTGCTAAATAAAAGTACTCAATGAACACAATTCTACATAAATTTTGACATACCATCTAATTTATAAAAA
TCAATAAAAAAGGTTTTGGTAAAACTTTTTCATGCCAGATGCTGTTTACAACAATGAACATGCCAATAAAACATTTGTTCATTCTGTTGT
GTTATTTTAGTCATTAAACTTCTGTGGATGAAGAATCTGGGTTAAGAATAGATTTGTCATCTTTAAATATGACATTTTGTAATGTGTATT
GGATATCTCATTTCTATGATAAAGGTATATTTACAGTAAAGTTCTCATAAGAGAAATGAAAAGCTGTGTTAATATCTAACTTTGGGGAAC
CCTGTCAGTATTTCAGATCCGATTTTTACCCTTTTTTTCTTATAAGAAAGATAAAATTAGAAAATACTGTTAGCAAATGTGGCTCTGCCA
TTTGAATATAATCACCGAGAATTCCATGTCTTAAAAGTCTCCTGGAATCCACAATGAAAAAAAAAATCTTTTCTAAGGTATTTTTCTGGC
TAATTTTTATTTGAAGAAAGCTATAGCATTTAGCGAAATTTGACTGAAGTAATGTTCTGAGTTTGCATTAGTGGGATTGGTGATGTTCTC
AGAAGAAAATTGGAAACACTTGTGATGAATTGTCTTTCAGATCACTTAGATTTTCTGATGTAAGAGGACAGCTGTTTGGTTCTGATACAG
GCCTGCTTACTTGGGATGTAGGGTTAGTAAATGGGGTTTCTGCTTTAAAGGACTGACTTGCTATCACACAAAAGAGGCAGACTTGTAAAC
ACAATGGGCTTTGGAGTTTGGTCTGATTGGGTTTGGTTTAGTATTCCTATGAGCGTAAATGGTAAAATTCTTCTGATACCCACTCTTTAG
ACTGTGCCTTCTGCTCTGTTCTTTGTTTTATGTTTAACTGCTGTTTCTAATTGCAGGTGTATTACAGATACAAATAAGAGTAAAGAAAAT
ATATTTCATTATAGAAAAGAAAAAATTAAAAGCTTCTTGCTTTTCAGTGCCTGATAGAGTGAAAACACAAAGTTGCACTTTAATAATTTC
AATAAAAGCTAATCTGTGTCAGCCTCCCTCTGCTTCAGAGAGTCAGGTGAGCATCCATAACCTAACAGGCAGAGCCCTAGCGATGTGGAT
CAAGTTTCCTGAGCCCGGGGGCGGTGGAGCCTCATGATCTCTTATCTTTTGAGGCTGAGGCAGGTCACATGCAACAAATTGTGACCCTGC
TCCCCACAAGTCATGCAAAGGTTTTGAAGAGCTTTTACCGTGGGGCAGATGAACTTGTGTCAACCATGCACACCCTGTGAGAACCAAGTA
CCTGTGTTTCTAAGGCGGGCACTCAAGGTGAGGGGTGCATTCTGGCCAAAGAAACAAAAGCTGTGGTTTCAGGACCATGCCGTGTGTAGC
TGATCTGTACGGGACGTGTATGTAAGGAAGAGCAATCATGATAGATAAGAACAGTGTGTGAAGCAGCCTTCACACTAGAGTGTTTGGTCA
TCTCTTATAATGTAAGGGAAGGTACTTTAAAATTCTGGGAAGATGCGATGAACTCATGTCCCAGTCAGAAAATAATCCAATGAAATAAGC
ATTGGTTGCCAGGCCACAGTTAGGAATTGTATTGTGATACATCTAGAGGCCAAGAGAGCAGGAGAGAGCTACCAACTTACACTGTGGTTT
AAGCTAAATGACCGCACAGCATCATAGCATTGCAGTGTTGTTACTAAATCTGGAAGTGACCTGTGAATGTATGGAATACAATAAAGTCTT
TTATTCTGGTTCATTTGCTAGTACTTCCTTTTTGATTGGATACTGTAGTTCTTCCTCTGGATTTTATTTTGTTCAGCGTCAAGGCCCTAA
TTTTGCAAATGTAGTCTAAACCACATTACGTGGACTAGAGGATACTCTGAATTAGCAAGTTTTTTGTTTGCTGAATAAAACTATTCCATC

>62883_62883_1_PARVA-USP47_PARVA_chr11_12399330_ENST00000334956_USP47_chr11_11974288_ENST00000339865_length(amino acids)=356AA_BP=195
MGQSELTSRRLEDPGRVAGLGWFSDVFCARLCGGDRAWVNEAFRLDRSQPGHTRPPVLQGAVLGHPPCLGQPRGARRGPGSAAPSRAEGG
AREGAREGAREGKGERELPQMLGIIPLPFGKPQPQSRRRPLRPPSASSASRPARGSLRRAMATSPQKSPSVPKSPTPKSPPSRKKDDSFL
GKLGGTLARRKKAKEGVEKMKSMSQLAVLSRRWKPSEMKLDPFQEVVLESSSVDELREKLSEISGIPLDDIEFAKGRGTFPCDISVLDIH

--------------------------------------------------------------
>62883_62883_2_PARVA-USP47_PARVA_chr11_12399330_ENST00000539723_USP47_chr11_11974288_ENST00000339865_length(transcript)=3854nt_BP=221nt
GCAGCCTCAGTCCCGCCGCCGCCCGCTGCGTCCGCCCAGCGCCAGCTCCGCGTCCCGACCGGCCCGCGGCAGCCTGCGCCGCGCCATGGC
CACCTCCCCGCAGAAGTCGCCTTCTGTCCCCAAGTCTCCCACTCCCAAGTCGCCCCCGTCCCGCAAGAAAGATGATTCCTTCTTGGGGAA
ACTCGGAGGGACCCTGGCCCGGAGGAAGAAAGCCAAGGAGGGGGTAGAGAAGATGAAGTCCATGTCACAGCTTGCAGTTTTGTCAAGACG
GTGGAAGCCTTCAGAGATGAAGTTGGATCCCTTCCAGGAGGTTGTATTGGAAAGCAGTAGTGTGGACGAATTGCGAGAGAAGCTTAGTGA
AATCAGTGGGATTCCTTTGGATGATATTGAATTTGCTAAGGGTAGAGGAACATTTCCCTGTGATATTTCTGTCCTTGATATTCATCAGGA
TTTAGACTGGAATCCTAAAGTTTCTACCCTGAATGTCTGGCCTCTTTATATCTGTGATGATGGTGCGGTCATATTTTATAGGGATAAAAC
AGAAGAATTAATGGAATTGACAGATGAGCAAAGAAATGAACTGATGAAAAAAGAAAGCAGTCGACTCCAGAAGACTGGACATCGTGTAAC
ATACTCACCTCGTAAAGAGAAAGCACTAAAAATATATCTGGATGGAGCACCAAATAAAGATCTGACTCAAGACTGACTCTGATAGTGTAG
CATTTTCCCTGGGGGAGTTTTGGTTTTAATTAGATGGTTCACTACCACTGGGTAGTGCCATTTTGGCCGGACATGGTTGGGGTAACCCAG
TGACACCAGCACTGATTGGACTGCCCTACACCAATCAGAAGCTCAGTGCCCAATGGGCCACTGTTTTGACTCGGAATCATGTTGTGCACT
ATAGTCAAATGTACTGTAAAGTGAAAAGGGATGTGCAAAAAAATAAAAAAAAACAACAAAAAAAGCTAACCTTCTATTAGAAAAGGGGAC
AGGGGAATGAGTAAACTTCTTTTATTGCGGACAAATGTGCACATAGCCGCTAGTAAAACTAGCCTCAAACAGGATGCTCATAGCTTAATA
ATAAAAGCTGTGCAAAGGCCATGAATGAATGAATTTTCTGTTTATTTCACTGATGCACACATTACCTCATTGACAATTCAGAAGTAAATC
CAACGTGTGTTGACTCTTGGAAAGCAGCAAAAACAGGAGCTGAAGAAAAGAAATTCTTGGAACCAGCCGTAACCCAGTAAGGAATTGTGA
AGTTGTGTTTTTATTTTGTTTCATTTTTTGCAGAGTATTAAGAACATTATTCTGGAACATCAGAACGTTTCCCTTAGACCGATCCCAGCA
GGTGGCAGCTCAGATTGCTGCAGTGTTGTAATTATAACTGATTGTACTTAAGTTATGGATGTAGAGAATATGTTTCATTCATTTATTCAG
CATGTAAATAAAATTGATCCTGTTGAGTTATCATAATTGCAGTTCAACTATCTGCCATGATTATTCTTTTCACGTATCATTCATTCTGTA
CATTTGTGTACATTGAGAAGTATAGCAATCTATGTAAATGTAATCCTCAGTGAGGTTCCTCAGTGCTAGGTCCCATAGGATTGTCGTTGC
CCTTGTTAATGAGGTTTCTCTGTTCAGCGGCTTCAATTTTTTTCTCTTTGTACATCTAGTTTTGAAGATTTACTTCAAGTTTGAATCTTC
TAGAATGCTTGTAAGTCCAGTTTTAATTTTTAGAGTCAATTTGTAGTTACATGTAGTTTAACTTTTGGGAAACGTCTTAACATTGTTCTG
AATAAACTTGCTAATGAGGTCAGGTCATGGTACAGACTGATGCAGTCAACATGATTTCATTGCAGAGTTTATTAGTATCAGCAAGTTTTT
GCTTTGCTAAATAAAAGTACTCAATGAACACAATTCTACATAAATTTTGACATACCATCTAATTTATAAAAATCAATAAAAAAGGTTTTG
GTAAAACTTTTTCATGCCAGATGCTGTTTACAACAATGAACATGCCAATAAAACATTTGTTCATTCTGTTGTGTTATTTTAGTCATTAAA
CTTCTGTGGATGAAGAATCTGGGTTAAGAATAGATTTGTCATCTTTAAATATGACATTTTGTAATGTGTATTGGATATCTCATTTCTATG
ATAAAGGTATATTTACAGTAAAGTTCTCATAAGAGAAATGAAAAGCTGTGTTAATATCTAACTTTGGGGAACCCTGTCAGTATTTCAGAT
CCGATTTTTACCCTTTTTTTCTTATAAGAAAGATAAAATTAGAAAATACTGTTAGCAAATGTGGCTCTGCCATTTGAATATAATCACCGA
GAATTCCATGTCTTAAAAGTCTCCTGGAATCCACAATGAAAAAAAAAATCTTTTCTAAGGTATTTTTCTGGCTAATTTTTATTTGAAGAA
AGCTATAGCATTTAGCGAAATTTGACTGAAGTAATGTTCTGAGTTTGCATTAGTGGGATTGGTGATGTTCTCAGAAGAAAATTGGAAACA
CTTGTGATGAATTGTCTTTCAGATCACTTAGATTTTCTGATGTAAGAGGACAGCTGTTTGGTTCTGATACAGGCCTGCTTACTTGGGATG
TAGGGTTAGTAAATGGGGTTTCTGCTTTAAAGGACTGACTTGCTATCACACAAAAGAGGCAGACTTGTAAACACAATGGGCTTTGGAGTT
TGGTCTGATTGGGTTTGGTTTAGTATTCCTATGAGCGTAAATGGTAAAATTCTTCTGATACCCACTCTTTAGACTGTGCCTTCTGCTCTG
TTCTTTGTTTTATGTTTAACTGCTGTTTCTAATTGCAGGTGTATTACAGATACAAATAAGAGTAAAGAAAATATATTTCATTATAGAAAA
GAAAAAATTAAAAGCTTCTTGCTTTTCAGTGCCTGATAGAGTGAAAACACAAAGTTGCACTTTAATAATTTCAATAAAAGCTAATCTGTG
TCAGCCTCCCTCTGCTTCAGAGAGTCAGGTGAGCATCCATAACCTAACAGGCAGAGCCCTAGCGATGTGGATCAAGTTTCCTGAGCCCGG
GGGCGGTGGAGCCTCATGATCTCTTATCTTTTGAGGCTGAGGCAGGTCACATGCAACAAATTGTGACCCTGCTCCCCACAAGTCATGCAA
AGGTTTTGAAGAGCTTTTACCGTGGGGCAGATGAACTTGTGTCAACCATGCACACCCTGTGAGAACCAAGTACCTGTGTTTCTAAGGCGG
GCACTCAAGGTGAGGGGTGCATTCTGGCCAAAGAAACAAAAGCTGTGGTTTCAGGACCATGCCGTGTGTAGCTGATCTGTACGGGACGTG
TATGTAAGGAAGAGCAATCATGATAGATAAGAACAGTGTGTGAAGCAGCCTTCACACTAGAGTGTTTGGTCATCTCTTATAATGTAAGGG
AAGGTACTTTAAAATTCTGGGAAGATGCGATGAACTCATGTCCCAGTCAGAAAATAATCCAATGAAATAAGCATTGGTTGCCAGGCCACA
GTTAGGAATTGTATTGTGATACATCTAGAGGCCAAGAGAGCAGGAGAGAGCTACCAACTTACACTGTGGTTTAAGCTAAATGACCGCACA
GCATCATAGCATTGCAGTGTTGTTACTAAATCTGGAAGTGACCTGTGAATGTATGGAATACAATAAAGTCTTTTATTCTGGTTCATTTGC
TAGTACTTCCTTTTTGATTGGATACTGTAGTTCTTCCTCTGGATTTTATTTTGTTCAGCGTCAAGGCCCTAATTTTGCAAATGTAGTCTA

>62883_62883_2_PARVA-USP47_PARVA_chr11_12399330_ENST00000539723_USP47_chr11_11974288_ENST00000339865_length(amino acids)=226AA_BP=65
MRPPSASSASRPARGSLRRAMATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEGVEKMKSMSQLAVLSRRWKPSEMKL
DPFQEVVLESSSVDELREKLSEISGIPLDDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDKTEELMELTD

--------------------------------------------------------------
>62883_62883_3_PARVA-USP47_PARVA_chr11_12399330_ENST00000550549_USP47_chr11_11974288_ENST00000339865_length(transcript)=3818nt_BP=185nt
CAGCGCCAGCTCCGCGTCCCGACCGGCCCGCGGCAGCCTGCGCCGCGCCATGGCCACCTCCCCGCAGAAGTCGCCTTCTGTCCCCAAGTC
TCCCACTCCCAAGTCGCCCCCGTCCCGCAAGAAAGATGATTCCTTCTTGGGGAAACTCGGAGGGACCCTGGCCCGGAGGAAGAAAGCCAA
GGAGGGGGTAGAGAAGATGAAGTCCATGTCACAGCTTGCAGTTTTGTCAAGACGGTGGAAGCCTTCAGAGATGAAGTTGGATCCCTTCCA
GGAGGTTGTATTGGAAAGCAGTAGTGTGGACGAATTGCGAGAGAAGCTTAGTGAAATCAGTGGGATTCCTTTGGATGATATTGAATTTGC
TAAGGGTAGAGGAACATTTCCCTGTGATATTTCTGTCCTTGATATTCATCAGGATTTAGACTGGAATCCTAAAGTTTCTACCCTGAATGT
CTGGCCTCTTTATATCTGTGATGATGGTGCGGTCATATTTTATAGGGATAAAACAGAAGAATTAATGGAATTGACAGATGAGCAAAGAAA
TGAACTGATGAAAAAAGAAAGCAGTCGACTCCAGAAGACTGGACATCGTGTAACATACTCACCTCGTAAAGAGAAAGCACTAAAAATATA
TCTGGATGGAGCACCAAATAAAGATCTGACTCAAGACTGACTCTGATAGTGTAGCATTTTCCCTGGGGGAGTTTTGGTTTTAATTAGATG
GTTCACTACCACTGGGTAGTGCCATTTTGGCCGGACATGGTTGGGGTAACCCAGTGACACCAGCACTGATTGGACTGCCCTACACCAATC
AGAAGCTCAGTGCCCAATGGGCCACTGTTTTGACTCGGAATCATGTTGTGCACTATAGTCAAATGTACTGTAAAGTGAAAAGGGATGTGC
AAAAAAATAAAAAAAAACAACAAAAAAAGCTAACCTTCTATTAGAAAAGGGGACAGGGGAATGAGTAAACTTCTTTTATTGCGGACAAAT
GTGCACATAGCCGCTAGTAAAACTAGCCTCAAACAGGATGCTCATAGCTTAATAATAAAAGCTGTGCAAAGGCCATGAATGAATGAATTT
TCTGTTTATTTCACTGATGCACACATTACCTCATTGACAATTCAGAAGTAAATCCAACGTGTGTTGACTCTTGGAAAGCAGCAAAAACAG
GAGCTGAAGAAAAGAAATTCTTGGAACCAGCCGTAACCCAGTAAGGAATTGTGAAGTTGTGTTTTTATTTTGTTTCATTTTTTGCAGAGT
ATTAAGAACATTATTCTGGAACATCAGAACGTTTCCCTTAGACCGATCCCAGCAGGTGGCAGCTCAGATTGCTGCAGTGTTGTAATTATA
ACTGATTGTACTTAAGTTATGGATGTAGAGAATATGTTTCATTCATTTATTCAGCATGTAAATAAAATTGATCCTGTTGAGTTATCATAA
TTGCAGTTCAACTATCTGCCATGATTATTCTTTTCACGTATCATTCATTCTGTACATTTGTGTACATTGAGAAGTATAGCAATCTATGTA
AATGTAATCCTCAGTGAGGTTCCTCAGTGCTAGGTCCCATAGGATTGTCGTTGCCCTTGTTAATGAGGTTTCTCTGTTCAGCGGCTTCAA
TTTTTTTCTCTTTGTACATCTAGTTTTGAAGATTTACTTCAAGTTTGAATCTTCTAGAATGCTTGTAAGTCCAGTTTTAATTTTTAGAGT
CAATTTGTAGTTACATGTAGTTTAACTTTTGGGAAACGTCTTAACATTGTTCTGAATAAACTTGCTAATGAGGTCAGGTCATGGTACAGA
CTGATGCAGTCAACATGATTTCATTGCAGAGTTTATTAGTATCAGCAAGTTTTTGCTTTGCTAAATAAAAGTACTCAATGAACACAATTC
TACATAAATTTTGACATACCATCTAATTTATAAAAATCAATAAAAAAGGTTTTGGTAAAACTTTTTCATGCCAGATGCTGTTTACAACAA
TGAACATGCCAATAAAACATTTGTTCATTCTGTTGTGTTATTTTAGTCATTAAACTTCTGTGGATGAAGAATCTGGGTTAAGAATAGATT
TGTCATCTTTAAATATGACATTTTGTAATGTGTATTGGATATCTCATTTCTATGATAAAGGTATATTTACAGTAAAGTTCTCATAAGAGA
AATGAAAAGCTGTGTTAATATCTAACTTTGGGGAACCCTGTCAGTATTTCAGATCCGATTTTTACCCTTTTTTTCTTATAAGAAAGATAA
AATTAGAAAATACTGTTAGCAAATGTGGCTCTGCCATTTGAATATAATCACCGAGAATTCCATGTCTTAAAAGTCTCCTGGAATCCACAA
TGAAAAAAAAAATCTTTTCTAAGGTATTTTTCTGGCTAATTTTTATTTGAAGAAAGCTATAGCATTTAGCGAAATTTGACTGAAGTAATG
TTCTGAGTTTGCATTAGTGGGATTGGTGATGTTCTCAGAAGAAAATTGGAAACACTTGTGATGAATTGTCTTTCAGATCACTTAGATTTT
CTGATGTAAGAGGACAGCTGTTTGGTTCTGATACAGGCCTGCTTACTTGGGATGTAGGGTTAGTAAATGGGGTTTCTGCTTTAAAGGACT
GACTTGCTATCACACAAAAGAGGCAGACTTGTAAACACAATGGGCTTTGGAGTTTGGTCTGATTGGGTTTGGTTTAGTATTCCTATGAGC
GTAAATGGTAAAATTCTTCTGATACCCACTCTTTAGACTGTGCCTTCTGCTCTGTTCTTTGTTTTATGTTTAACTGCTGTTTCTAATTGC
AGGTGTATTACAGATACAAATAAGAGTAAAGAAAATATATTTCATTATAGAAAAGAAAAAATTAAAAGCTTCTTGCTTTTCAGTGCCTGA
TAGAGTGAAAACACAAAGTTGCACTTTAATAATTTCAATAAAAGCTAATCTGTGTCAGCCTCCCTCTGCTTCAGAGAGTCAGGTGAGCAT
CCATAACCTAACAGGCAGAGCCCTAGCGATGTGGATCAAGTTTCCTGAGCCCGGGGGCGGTGGAGCCTCATGATCTCTTATCTTTTGAGG
CTGAGGCAGGTCACATGCAACAAATTGTGACCCTGCTCCCCACAAGTCATGCAAAGGTTTTGAAGAGCTTTTACCGTGGGGCAGATGAAC
TTGTGTCAACCATGCACACCCTGTGAGAACCAAGTACCTGTGTTTCTAAGGCGGGCACTCAAGGTGAGGGGTGCATTCTGGCCAAAGAAA
CAAAAGCTGTGGTTTCAGGACCATGCCGTGTGTAGCTGATCTGTACGGGACGTGTATGTAAGGAAGAGCAATCATGATAGATAAGAACAG
TGTGTGAAGCAGCCTTCACACTAGAGTGTTTGGTCATCTCTTATAATGTAAGGGAAGGTACTTTAAAATTCTGGGAAGATGCGATGAACT
CATGTCCCAGTCAGAAAATAATCCAATGAAATAAGCATTGGTTGCCAGGCCACAGTTAGGAATTGTATTGTGATACATCTAGAGGCCAAG
AGAGCAGGAGAGAGCTACCAACTTACACTGTGGTTTAAGCTAAATGACCGCACAGCATCATAGCATTGCAGTGTTGTTACTAAATCTGGA
AGTGACCTGTGAATGTATGGAATACAATAAAGTCTTTTATTCTGGTTCATTTGCTAGTACTTCCTTTTTGATTGGATACTGTAGTTCTTC
CTCTGGATTTTATTTTGTTCAGCGTCAAGGCCCTAATTTTGCAAATGTAGTCTAAACCACATTACGTGGACTAGAGGATACTCTGAATTA

>62883_62883_3_PARVA-USP47_PARVA_chr11_12399330_ENST00000550549_USP47_chr11_11974288_ENST00000339865_length(amino acids)=210AA_BP=49
MRRAMATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEGVEKMKSMSQLAVLSRRWKPSEMKLDPFQEVVLESSSVDEL
REKLSEISGIPLDDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDKTEELMELTDEQRNELMKKESSRLQK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PARVA-USP47


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgenePARVAchr11:12399330chr11:11974288ENST00000550549+11321_2545.333333333333336373.0ARHGAP31


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PARVA-USP47


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PARVA-USP47


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource