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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PAX5-KANK1 (FusionGDB2 ID:62952)

Fusion Gene Summary for PAX5-KANK1

check button Fusion gene summary
Fusion gene informationFusion gene name: PAX5-KANK1
Fusion gene ID: 62952
HgeneTgene
Gene symbol

PAX5

KANK1

Gene ID

5079

23189

Gene namepaired box 5KN motif and ankyrin repeat domains 1
SynonymsALL3|BSAPANKRD15|CPSQ2|KANK
Cytomap

9p13.2

9p24.3

Type of geneprotein-codingprotein-coding
Descriptionpaired box protein Pax-5B-cell lineage specific activatorpaired box homeotic gene 5paired domain gene 5transcription factor PAX 5KN motif and ankyrin repeat domain-containing protein 1ankyrin repeat domain-containing protein 15kidney ankyrin repeat-containing protein
Modification date2020031320200313
UniProtAcc.

Q14678

Ensembl transtripts involved in fusion geneENST00000358127, ENST00000377847, 
ENST00000377852, ENST00000377853, 
ENST00000446742, ENST00000520154, 
ENST00000522003, ENST00000523145, 
ENST00000523241, ENST00000414447, 
ENST00000520281, 		ENST00000382293, 
ENST00000382297, ENST00000489369, 
ENST00000382303, 
Fusion gene scores* DoF score15 X 15 X 7=157511 X 9 X 8=792
# samples 1012
** MAII scorelog2(10/1575*10)=-3.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/792*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAX5 [Title/Abstract] AND KANK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint
Anticipated loss of major functional domain due to fusion event.PAX5-KANK1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PAX5-KANK1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
PAX5-KANK1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PAX5-KANK1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKANK1

GO:0010977

negative regulation of neuron projection development

19171758

TgeneKANK1

GO:0030177

positive regulation of Wnt signaling pathway

16968744

TgeneKANK1

GO:0030837

negative regulation of actin filament polymerization

17996375|18458160

TgeneKANK1

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

19171758

TgeneKANK1

GO:1900028

negative regulation of ruffle assembly

19171758

TgeneKANK1

GO:2000393

negative regulation of lamellipodium morphogenesis

19171758


check buttonFusion gene breakpoints across PAX5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KANK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..PAX5chr9

37002644

-KANK1chr9

730049

+


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Fusion Gene ORF analysis for PAX5-KANK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000358127ENST00000382293PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000358127ENST00000382297PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000358127ENST00000489369PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000377847ENST00000382293PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000377847ENST00000382297PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000377847ENST00000489369PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000377852ENST00000382293PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000377852ENST00000382297PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000377852ENST00000489369PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000377853ENST00000382293PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000377853ENST00000382297PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000377853ENST00000489369PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000446742ENST00000382293PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000446742ENST00000382297PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000446742ENST00000489369PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000520154ENST00000382293PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000520154ENST00000382297PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000520154ENST00000489369PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000522003ENST00000382293PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000522003ENST00000382297PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000522003ENST00000489369PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000523145ENST00000382293PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000523145ENST00000382297PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000523145ENST00000489369PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000523241ENST00000382293PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000523241ENST00000382297PAX5chr9

37002644

-KANK1chr9

730049

+
5CDS-3UTRENST00000523241ENST00000489369PAX5chr9

37002644

-KANK1chr9

730049

+
Frame-shiftENST00000522003ENST00000382303PAX5chr9

37002644

-KANK1chr9

730049

+
Frame-shiftENST00000523145ENST00000382303PAX5chr9

37002644

-KANK1chr9

730049

+
In-frameENST00000358127ENST00000382303PAX5chr9

37002644

-KANK1chr9

730049

+
In-frameENST00000377847ENST00000382303PAX5chr9

37002644

-KANK1chr9

730049

+
In-frameENST00000377852ENST00000382303PAX5chr9

37002644

-KANK1chr9

730049

+
In-frameENST00000377853ENST00000382303PAX5chr9

37002644

-KANK1chr9

730049

+
In-frameENST00000446742ENST00000382303PAX5chr9

37002644

-KANK1chr9

730049

+
In-frameENST00000520154ENST00000382303PAX5chr9

37002644

-KANK1chr9

730049

+
In-frameENST00000523241ENST00000382303PAX5chr9

37002644

-KANK1chr9

730049

+
intron-3CDSENST00000414447ENST00000382303PAX5chr9

37002644

-KANK1chr9

730049

+
intron-3CDSENST00000520281ENST00000382303PAX5chr9

37002644

-KANK1chr9

730049

+
intron-3UTRENST00000414447ENST00000382293PAX5chr9

37002644

-KANK1chr9

730049

+
intron-3UTRENST00000414447ENST00000382297PAX5chr9

37002644

-KANK1chr9

730049

+
intron-3UTRENST00000414447ENST00000489369PAX5chr9

37002644

-KANK1chr9

730049

+
intron-3UTRENST00000520281ENST00000382293PAX5chr9

37002644

-KANK1chr9

730049

+
intron-3UTRENST00000520281ENST00000382297PAX5chr9

37002644

-KANK1chr9

730049

+
intron-3UTRENST00000520281ENST00000489369PAX5chr9

37002644

-KANK1chr9

730049

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358127PAX5chr937002644-ENST00000382303KANK1chr9730049+2910679752039654
ENST00000523241PAX5chr937002644-ENST00000382303KANK1chr9730049+2845614101974654
ENST00000520154PAX5chr937002644-ENST00000382303KANK1chr9730049+2845614101974654
ENST00000377852PAX5chr937002644-ENST00000382303KANK1chr9730049+2845614101974654
ENST00000377853PAX5chr937002644-ENST00000382303KANK1chr9730049+2845614101974654
ENST00000446742PAX5chr937002644-ENST00000382303KANK1chr9730049+263740601766588
ENST00000377847PAX5chr937002644-ENST00000382303KANK1chr9730049+283560401964654

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PAX5-KANK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PAX5-KANK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:/chr9:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KANK1

Q14678

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration (PubMed:25961457). Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1 (PubMed:25961457). Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways (PubMed:25961457). {ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:25961457}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PAX5-KANK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>62952_62952_1_PAX5-KANK1_PAX5_chr9_37002644_ENST00000358127_KANK1_chr9_730049_ENST00000382303_length(transcript)=2910nt_BP=679nt
AAAAAAAAGAAAAAAAAAGGCACAAAAAAGTGGAAACTTTTCCCTGTCCATTCCATCAAGTCCTGAAAAATCAAAATGGATTTAGAGAAA
AATTATCCGACTCCTCGGACCAGCAGGACAGGACATGGAGGAGTGAATCAGCTTGGGGGGGTTTTTGTGAATGGACGGCCACTCCCGGAT
GTAGTCCGCCAGAGGATAGTGGAACTTGCTCATCAAGGTGTCAGGCCCTGCGACATCTCCAGGCAGCTTCGGGTCAGCCATGGTTGTGTC
AGCAAAATTCTTGGCAGGTATTATGAGACAGGAAGCATCAAGCCTGGGGTAATTGGAGGATCCAAACCAAAGGTCGCCACACCCAAAGTG
GTGGAAAAAATCGCTGAATATAAACGCCAAAATCCCACCATGTTTGCCTGGGAGATCAGGGACCGGCTGCTGGCAGAGCGGGTGTGTGAC
AATGACACCGTGCCTAGCGTCAGTTCCATCAACAGGATCATCCGGACAAAAGTACAGCAGCCACCCAACCAACCAGTCCCAGCTTCCAGT
CACAGCATAGTGTCCACTGGCTCCGTGACGCAGGTGTCCTCGGTGAGCACGGATTCGGCCGGCTCGTCGTACTCCATCAGCGGCATCCTG
GGCATCACGTCCCCCAGCGCCGACACCAACAAGCGCAAGAGAGACGAAGGCAATTATTTGGGATATACCTGTAAGTGTGGGGGCCTTCAG
TCAGGAAGTCCCTTAAGCTCCCAGACATCCCAGCCTGAGCAAGAAGTGGGGACCTCAGAAGGAAAGCCAATCAGCAGCCTGGATGCCTTC
CCCACTCAGGAAGGTACGCTGTCTCCAGTGAACCTGACAGACGACCAGATCGCCGCTGGCCTCTATGCATGTACAAACAATGAAAGTACA
CTGAAGTCCATCATGAAGAAGAAAGATGGTAACAAAGATTCAAATGGCGCAAAAAAGAATCTTCAGTTTGTTGGCATTAATGGAGGGTAT
GAAACAACTTCAAGTGATGATTCCAGCTCAGATGAAAGCTCTTCTTCCGAGTCAGATGACGAGTGTGATGTCATTGAGTATCCTCTTGAA
GAAGAGGAGGAGGAGGAGGATGAAGACACTCGGGGAATGGCAGAAGGGCACCATGCAGTTAATATTGAAGGTTTGAAGTCTGCCAGGGTG
GAAGATGAAATGCAGGTTCAAGAATGTGAACCTGAGAAGGTGGAAATCAGAGAGAGGTATGAATTAAGTGAAAAGATGTTGTCTGCATGC
AACTTACTGAAAAATACTATAAATGACCCCAAAGCTTTGACCAGCAAAGATATGAGGTTCTGTCTGAACACCCTCCAGCACGAGTGGTTC
CGCGTGTCCAGTCAGAAGTCAGCCATTCCAGCCATGGTGGGGGACTACATAGCTGCTTTTGAGGCCATTTCCCCAGATGTCCTCCGCTAT
GTCATCAACTTGGCAGACGGCAACGGCAACACAGCCCTCCATTACAGCGTGTCCCACTCCAACTTCGAGATTGTGAAGCTGCTGTTAGAT
GCCGATGTGTGTAATGTGGATCACCAGAACAAGGCAGGCTACACCCCCATCATGTTGGCGGCCCTCGCCGCTGTGGAAGCAGAGAAGGAC
ATGCGGATTGTGGAAGAACTCTTCGGCTGTGGGGATGTGAATGCCAAAGCTAGTCAGGCGGGACAGACGGCCCTCATGCTGGCGGTCAGT
CACGGACGGATAGACATGGTGAAGGGCCTTCTGGCCTGTGGGGCTGATGTCAACATCCAGGATGACGAGGGCTCCACGGCCCTCATGTGT
GCCAGCGAGCACGGACACGTGGAGATTGTCAAGCTGCTGCTGGCCCAGCCCGGCTGCAACGGTCACCTAGAGGACAACGATGGCAGCACT
GCGCTCTCAATCGCCCTGGAAGCAGGACACAAGGACATCGCTGTTCTTCTGTATGCCCATGTCAACTTTGCAAAAGCCCAGTCTCCGGGC
ACCCCTAGGCTTGGAAGGAAGACGTCTCCTGGCCCCACCCACCGAGGTTCATTTGATTGATTGTATGCAAATAGCCCTTTATTTACATGC
CACTATTAAGCTGCTAATTGTTCCTGTTGGGGTGACAGATACTGAATGTATACGTATTGTGCCTGAGCTCACCAGCAAACAGAAGCATCA
AGCCCAGGGGTAAAGGCTGAAGCTTTCACAGTGCAGAGACTGCTAGCCTGGGCACACACACCTCCTTTCTGGCCGTCTTCTGTGTAGGGC
ACACTTTAACCCAGTCTCTGTTGCTGTTGAGTCTCTGCTCCGTTTTGTACAGTCACAGGGAATTCTGATCTGAAGGGGCACCTTCTGTTC
ACTCCCACAAAGTGGTGTCTGGTTCTCACTGAGACGTTTTAAGATTTTTCCACAAATATTTATATGTACTAAATGTGGAACCATTAGAAA
GTTCTTCCAAAATCTCATTCCAGCATAGTTTTGGATTTTTCTTTTGTCTTATTTTAAAATAAGGAAGTCGAGATGACTTTGATCATTGGT
AACTTGGGCCTGGGCCAGACAAAGTATAAAACTTACAAAAGAATATTCTCATTTGGTCTTAACTAGGTAGATGTAATATATGACTTTTTA
TAAAAAGGGTATCTATATGAACTTGACACAGTATTTTCAGCTTTTGTATTCCATACTAAAGCCATGAAGAACTACACGTAACATCATCAT
TTGTATTAATTGCACAACTCCAATGCTAAAGGTTGGATTGTGTTAGAGGAATCGGCTCTGTATTTGCCTCTAGAGAAACACAGTGTTCTC
TTTGTATTTATGGATTCCTTTTTACCGTGTCACATTTACTTTGGTCCTCTATGTATTTAAATGTTTGAAGTGCCTTAGACTCTTGCCATA

>62952_62952_1_PAX5-KANK1_PAX5_chr9_37002644_ENST00000358127_KANK1_chr9_730049_ENST00000382303_length(amino acids)=654AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACT
NNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGL
KSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISP
DVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTAL
MLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAK

--------------------------------------------------------------
>62952_62952_2_PAX5-KANK1_PAX5_chr9_37002644_ENST00000377847_KANK1_chr9_730049_ENST00000382303_length(transcript)=2835nt_BP=604nt
ATGGATTTAGAGAAAAATTATCCGACTCCTCGGACCAGCAGGACAGGACATGGAGGAGTGAATCAGCTTGGGGGGGTTTTTGTGAATGGA
CGGCCACTCCCGGATGTAGTCCGCCAGAGGATAGTGGAACTTGCTCATCAAGGTGTCAGGCCCTGCGACATCTCCAGGCAGCTTCGGGTC
AGCCATGGTTGTGTCAGCAAAATTCTTGGCAGGTATTATGAGACAGGAAGCATCAAGCCTGGGGTAATTGGAGGATCCAAACCAAAGGTC
GCCACACCCAAAGTGGTGGAAAAAATCGCTGAATATAAACGCCAAAATCCCACCATGTTTGCCTGGGAGATCAGGGACCGGCTGCTGGCA
GAGCGGGTGTGTGACAATGACACCGTGCCTAGCGTCAGTTCCATCAACAGGATCATCCGGACAAAAGTACAGCAGCCACCCAACCAACCA
GTCCCAGCTTCCAGTCACAGCATAGTGTCCACTGGCTCCGTGACGCAGGTGTCCTCGGTGAGCACGGATTCGGCCGGCTCGTCGTACTCC
ATCAGCGGCATCCTGGGCATCACGTCCCCCAGCGCCGACACCAACAAGCGCAAGAGAGACGAAGGCAATTATTTGGGATATACCTGTAAG
TGTGGGGGCCTTCAGTCAGGAAGTCCCTTAAGCTCCCAGACATCCCAGCCTGAGCAAGAAGTGGGGACCTCAGAAGGAAAGCCAATCAGC
AGCCTGGATGCCTTCCCCACTCAGGAAGGTACGCTGTCTCCAGTGAACCTGACAGACGACCAGATCGCCGCTGGCCTCTATGCATGTACA
AACAATGAAAGTACACTGAAGTCCATCATGAAGAAGAAAGATGGTAACAAAGATTCAAATGGCGCAAAAAAGAATCTTCAGTTTGTTGGC
ATTAATGGAGGGTATGAAACAACTTCAAGTGATGATTCCAGCTCAGATGAAAGCTCTTCTTCCGAGTCAGATGACGAGTGTGATGTCATT
GAGTATCCTCTTGAAGAAGAGGAGGAGGAGGAGGATGAAGACACTCGGGGAATGGCAGAAGGGCACCATGCAGTTAATATTGAAGGTTTG
AAGTCTGCCAGGGTGGAAGATGAAATGCAGGTTCAAGAATGTGAACCTGAGAAGGTGGAAATCAGAGAGAGGTATGAATTAAGTGAAAAG
ATGTTGTCTGCATGCAACTTACTGAAAAATACTATAAATGACCCCAAAGCTTTGACCAGCAAAGATATGAGGTTCTGTCTGAACACCCTC
CAGCACGAGTGGTTCCGCGTGTCCAGTCAGAAGTCAGCCATTCCAGCCATGGTGGGGGACTACATAGCTGCTTTTGAGGCCATTTCCCCA
GATGTCCTCCGCTATGTCATCAACTTGGCAGACGGCAACGGCAACACAGCCCTCCATTACAGCGTGTCCCACTCCAACTTCGAGATTGTG
AAGCTGCTGTTAGATGCCGATGTGTGTAATGTGGATCACCAGAACAAGGCAGGCTACACCCCCATCATGTTGGCGGCCCTCGCCGCTGTG
GAAGCAGAGAAGGACATGCGGATTGTGGAAGAACTCTTCGGCTGTGGGGATGTGAATGCCAAAGCTAGTCAGGCGGGACAGACGGCCCTC
ATGCTGGCGGTCAGTCACGGACGGATAGACATGGTGAAGGGCCTTCTGGCCTGTGGGGCTGATGTCAACATCCAGGATGACGAGGGCTCC
ACGGCCCTCATGTGTGCCAGCGAGCACGGACACGTGGAGATTGTCAAGCTGCTGCTGGCCCAGCCCGGCTGCAACGGTCACCTAGAGGAC
AACGATGGCAGCACTGCGCTCTCAATCGCCCTGGAAGCAGGACACAAGGACATCGCTGTTCTTCTGTATGCCCATGTCAACTTTGCAAAA
GCCCAGTCTCCGGGCACCCCTAGGCTTGGAAGGAAGACGTCTCCTGGCCCCACCCACCGAGGTTCATTTGATTGATTGTATGCAAATAGC
CCTTTATTTACATGCCACTATTAAGCTGCTAATTGTTCCTGTTGGGGTGACAGATACTGAATGTATACGTATTGTGCCTGAGCTCACCAG
CAAACAGAAGCATCAAGCCCAGGGGTAAAGGCTGAAGCTTTCACAGTGCAGAGACTGCTAGCCTGGGCACACACACCTCCTTTCTGGCCG
TCTTCTGTGTAGGGCACACTTTAACCCAGTCTCTGTTGCTGTTGAGTCTCTGCTCCGTTTTGTACAGTCACAGGGAATTCTGATCTGAAG
GGGCACCTTCTGTTCACTCCCACAAAGTGGTGTCTGGTTCTCACTGAGACGTTTTAAGATTTTTCCACAAATATTTATATGTACTAAATG
TGGAACCATTAGAAAGTTCTTCCAAAATCTCATTCCAGCATAGTTTTGGATTTTTCTTTTGTCTTATTTTAAAATAAGGAAGTCGAGATG
ACTTTGATCATTGGTAACTTGGGCCTGGGCCAGACAAAGTATAAAACTTACAAAAGAATATTCTCATTTGGTCTTAACTAGGTAGATGTA
ATATATGACTTTTTATAAAAAGGGTATCTATATGAACTTGACACAGTATTTTCAGCTTTTGTATTCCATACTAAAGCCATGAAGAACTAC
ACGTAACATCATCATTTGTATTAATTGCACAACTCCAATGCTAAAGGTTGGATTGTGTTAGAGGAATCGGCTCTGTATTTGCCTCTAGAG
AAACACAGTGTTCTCTTTGTATTTATGGATTCCTTTTTACCGTGTCACATTTACTTTGGTCCTCTATGTATTTAAATGTTTGAAGTGCCT

>62952_62952_2_PAX5-KANK1_PAX5_chr9_37002644_ENST00000377847_KANK1_chr9_730049_ENST00000382303_length(amino acids)=654AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACT
NNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGL
KSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISP
DVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTAL
MLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAK

--------------------------------------------------------------
>62952_62952_3_PAX5-KANK1_PAX5_chr9_37002644_ENST00000377852_KANK1_chr9_730049_ENST00000382303_length(transcript)=2845nt_BP=614nt
AAAAATCAAAATGGATTTAGAGAAAAATTATCCGACTCCTCGGACCAGCAGGACAGGACATGGAGGAGTGAATCAGCTTGGGGGGGTTTT
TGTGAATGGACGGCCACTCCCGGATGTAGTCCGCCAGAGGATAGTGGAACTTGCTCATCAAGGTGTCAGGCCCTGCGACATCTCCAGGCA
GCTTCGGGTCAGCCATGGTTGTGTCAGCAAAATTCTTGGCAGGTATTATGAGACAGGAAGCATCAAGCCTGGGGTAATTGGAGGATCCAA
ACCAAAGGTCGCCACACCCAAAGTGGTGGAAAAAATCGCTGAATATAAACGCCAAAATCCCACCATGTTTGCCTGGGAGATCAGGGACCG
GCTGCTGGCAGAGCGGGTGTGTGACAATGACACCGTGCCTAGCGTCAGTTCCATCAACAGGATCATCCGGACAAAAGTACAGCAGCCACC
CAACCAACCAGTCCCAGCTTCCAGTCACAGCATAGTGTCCACTGGCTCCGTGACGCAGGTGTCCTCGGTGAGCACGGATTCGGCCGGCTC
GTCGTACTCCATCAGCGGCATCCTGGGCATCACGTCCCCCAGCGCCGACACCAACAAGCGCAAGAGAGACGAAGGCAATTATTTGGGATA
TACCTGTAAGTGTGGGGGCCTTCAGTCAGGAAGTCCCTTAAGCTCCCAGACATCCCAGCCTGAGCAAGAAGTGGGGACCTCAGAAGGAAA
GCCAATCAGCAGCCTGGATGCCTTCCCCACTCAGGAAGGTACGCTGTCTCCAGTGAACCTGACAGACGACCAGATCGCCGCTGGCCTCTA
TGCATGTACAAACAATGAAAGTACACTGAAGTCCATCATGAAGAAGAAAGATGGTAACAAAGATTCAAATGGCGCAAAAAAGAATCTTCA
GTTTGTTGGCATTAATGGAGGGTATGAAACAACTTCAAGTGATGATTCCAGCTCAGATGAAAGCTCTTCTTCCGAGTCAGATGACGAGTG
TGATGTCATTGAGTATCCTCTTGAAGAAGAGGAGGAGGAGGAGGATGAAGACACTCGGGGAATGGCAGAAGGGCACCATGCAGTTAATAT
TGAAGGTTTGAAGTCTGCCAGGGTGGAAGATGAAATGCAGGTTCAAGAATGTGAACCTGAGAAGGTGGAAATCAGAGAGAGGTATGAATT
AAGTGAAAAGATGTTGTCTGCATGCAACTTACTGAAAAATACTATAAATGACCCCAAAGCTTTGACCAGCAAAGATATGAGGTTCTGTCT
GAACACCCTCCAGCACGAGTGGTTCCGCGTGTCCAGTCAGAAGTCAGCCATTCCAGCCATGGTGGGGGACTACATAGCTGCTTTTGAGGC
CATTTCCCCAGATGTCCTCCGCTATGTCATCAACTTGGCAGACGGCAACGGCAACACAGCCCTCCATTACAGCGTGTCCCACTCCAACTT
CGAGATTGTGAAGCTGCTGTTAGATGCCGATGTGTGTAATGTGGATCACCAGAACAAGGCAGGCTACACCCCCATCATGTTGGCGGCCCT
CGCCGCTGTGGAAGCAGAGAAGGACATGCGGATTGTGGAAGAACTCTTCGGCTGTGGGGATGTGAATGCCAAAGCTAGTCAGGCGGGACA
GACGGCCCTCATGCTGGCGGTCAGTCACGGACGGATAGACATGGTGAAGGGCCTTCTGGCCTGTGGGGCTGATGTCAACATCCAGGATGA
CGAGGGCTCCACGGCCCTCATGTGTGCCAGCGAGCACGGACACGTGGAGATTGTCAAGCTGCTGCTGGCCCAGCCCGGCTGCAACGGTCA
CCTAGAGGACAACGATGGCAGCACTGCGCTCTCAATCGCCCTGGAAGCAGGACACAAGGACATCGCTGTTCTTCTGTATGCCCATGTCAA
CTTTGCAAAAGCCCAGTCTCCGGGCACCCCTAGGCTTGGAAGGAAGACGTCTCCTGGCCCCACCCACCGAGGTTCATTTGATTGATTGTA
TGCAAATAGCCCTTTATTTACATGCCACTATTAAGCTGCTAATTGTTCCTGTTGGGGTGACAGATACTGAATGTATACGTATTGTGCCTG
AGCTCACCAGCAAACAGAAGCATCAAGCCCAGGGGTAAAGGCTGAAGCTTTCACAGTGCAGAGACTGCTAGCCTGGGCACACACACCTCC
TTTCTGGCCGTCTTCTGTGTAGGGCACACTTTAACCCAGTCTCTGTTGCTGTTGAGTCTCTGCTCCGTTTTGTACAGTCACAGGGAATTC
TGATCTGAAGGGGCACCTTCTGTTCACTCCCACAAAGTGGTGTCTGGTTCTCACTGAGACGTTTTAAGATTTTTCCACAAATATTTATAT
GTACTAAATGTGGAACCATTAGAAAGTTCTTCCAAAATCTCATTCCAGCATAGTTTTGGATTTTTCTTTTGTCTTATTTTAAAATAAGGA
AGTCGAGATGACTTTGATCATTGGTAACTTGGGCCTGGGCCAGACAAAGTATAAAACTTACAAAAGAATATTCTCATTTGGTCTTAACTA
GGTAGATGTAATATATGACTTTTTATAAAAAGGGTATCTATATGAACTTGACACAGTATTTTCAGCTTTTGTATTCCATACTAAAGCCAT
GAAGAACTACACGTAACATCATCATTTGTATTAATTGCACAACTCCAATGCTAAAGGTTGGATTGTGTTAGAGGAATCGGCTCTGTATTT
GCCTCTAGAGAAACACAGTGTTCTCTTTGTATTTATGGATTCCTTTTTACCGTGTCACATTTACTTTGGTCCTCTATGTATTTAAATGTT

>62952_62952_3_PAX5-KANK1_PAX5_chr9_37002644_ENST00000377852_KANK1_chr9_730049_ENST00000382303_length(amino acids)=654AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACT
NNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGL
KSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISP
DVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTAL
MLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAK

--------------------------------------------------------------
>62952_62952_4_PAX5-KANK1_PAX5_chr9_37002644_ENST00000377853_KANK1_chr9_730049_ENST00000382303_length(transcript)=2845nt_BP=614nt
AAAAATCAAAATGGATTTAGAGAAAAATTATCCGACTCCTCGGACCAGCAGGACAGGACATGGAGGAGTGAATCAGCTTGGGGGGGTTTT
TGTGAATGGACGGCCACTCCCGGATGTAGTCCGCCAGAGGATAGTGGAACTTGCTCATCAAGGTGTCAGGCCCTGCGACATCTCCAGGCA
GCTTCGGGTCAGCCATGGTTGTGTCAGCAAAATTCTTGGCAGGTATTATGAGACAGGAAGCATCAAGCCTGGGGTAATTGGAGGATCCAA
ACCAAAGGTCGCCACACCCAAAGTGGTGGAAAAAATCGCTGAATATAAACGCCAAAATCCCACCATGTTTGCCTGGGAGATCAGGGACCG
GCTGCTGGCAGAGCGGGTGTGTGACAATGACACCGTGCCTAGCGTCAGTTCCATCAACAGGATCATCCGGACAAAAGTACAGCAGCCACC
CAACCAACCAGTCCCAGCTTCCAGTCACAGCATAGTGTCCACTGGCTCCGTGACGCAGGTGTCCTCGGTGAGCACGGATTCGGCCGGCTC
GTCGTACTCCATCAGCGGCATCCTGGGCATCACGTCCCCCAGCGCCGACACCAACAAGCGCAAGAGAGACGAAGGCAATTATTTGGGATA
TACCTGTAAGTGTGGGGGCCTTCAGTCAGGAAGTCCCTTAAGCTCCCAGACATCCCAGCCTGAGCAAGAAGTGGGGACCTCAGAAGGAAA
GCCAATCAGCAGCCTGGATGCCTTCCCCACTCAGGAAGGTACGCTGTCTCCAGTGAACCTGACAGACGACCAGATCGCCGCTGGCCTCTA
TGCATGTACAAACAATGAAAGTACACTGAAGTCCATCATGAAGAAGAAAGATGGTAACAAAGATTCAAATGGCGCAAAAAAGAATCTTCA
GTTTGTTGGCATTAATGGAGGGTATGAAACAACTTCAAGTGATGATTCCAGCTCAGATGAAAGCTCTTCTTCCGAGTCAGATGACGAGTG
TGATGTCATTGAGTATCCTCTTGAAGAAGAGGAGGAGGAGGAGGATGAAGACACTCGGGGAATGGCAGAAGGGCACCATGCAGTTAATAT
TGAAGGTTTGAAGTCTGCCAGGGTGGAAGATGAAATGCAGGTTCAAGAATGTGAACCTGAGAAGGTGGAAATCAGAGAGAGGTATGAATT
AAGTGAAAAGATGTTGTCTGCATGCAACTTACTGAAAAATACTATAAATGACCCCAAAGCTTTGACCAGCAAAGATATGAGGTTCTGTCT
GAACACCCTCCAGCACGAGTGGTTCCGCGTGTCCAGTCAGAAGTCAGCCATTCCAGCCATGGTGGGGGACTACATAGCTGCTTTTGAGGC
CATTTCCCCAGATGTCCTCCGCTATGTCATCAACTTGGCAGACGGCAACGGCAACACAGCCCTCCATTACAGCGTGTCCCACTCCAACTT
CGAGATTGTGAAGCTGCTGTTAGATGCCGATGTGTGTAATGTGGATCACCAGAACAAGGCAGGCTACACCCCCATCATGTTGGCGGCCCT
CGCCGCTGTGGAAGCAGAGAAGGACATGCGGATTGTGGAAGAACTCTTCGGCTGTGGGGATGTGAATGCCAAAGCTAGTCAGGCGGGACA
GACGGCCCTCATGCTGGCGGTCAGTCACGGACGGATAGACATGGTGAAGGGCCTTCTGGCCTGTGGGGCTGATGTCAACATCCAGGATGA
CGAGGGCTCCACGGCCCTCATGTGTGCCAGCGAGCACGGACACGTGGAGATTGTCAAGCTGCTGCTGGCCCAGCCCGGCTGCAACGGTCA
CCTAGAGGACAACGATGGCAGCACTGCGCTCTCAATCGCCCTGGAAGCAGGACACAAGGACATCGCTGTTCTTCTGTATGCCCATGTCAA
CTTTGCAAAAGCCCAGTCTCCGGGCACCCCTAGGCTTGGAAGGAAGACGTCTCCTGGCCCCACCCACCGAGGTTCATTTGATTGATTGTA
TGCAAATAGCCCTTTATTTACATGCCACTATTAAGCTGCTAATTGTTCCTGTTGGGGTGACAGATACTGAATGTATACGTATTGTGCCTG
AGCTCACCAGCAAACAGAAGCATCAAGCCCAGGGGTAAAGGCTGAAGCTTTCACAGTGCAGAGACTGCTAGCCTGGGCACACACACCTCC
TTTCTGGCCGTCTTCTGTGTAGGGCACACTTTAACCCAGTCTCTGTTGCTGTTGAGTCTCTGCTCCGTTTTGTACAGTCACAGGGAATTC
TGATCTGAAGGGGCACCTTCTGTTCACTCCCACAAAGTGGTGTCTGGTTCTCACTGAGACGTTTTAAGATTTTTCCACAAATATTTATAT
GTACTAAATGTGGAACCATTAGAAAGTTCTTCCAAAATCTCATTCCAGCATAGTTTTGGATTTTTCTTTTGTCTTATTTTAAAATAAGGA
AGTCGAGATGACTTTGATCATTGGTAACTTGGGCCTGGGCCAGACAAAGTATAAAACTTACAAAAGAATATTCTCATTTGGTCTTAACTA
GGTAGATGTAATATATGACTTTTTATAAAAAGGGTATCTATATGAACTTGACACAGTATTTTCAGCTTTTGTATTCCATACTAAAGCCAT
GAAGAACTACACGTAACATCATCATTTGTATTAATTGCACAACTCCAATGCTAAAGGTTGGATTGTGTTAGAGGAATCGGCTCTGTATTT
GCCTCTAGAGAAACACAGTGTTCTCTTTGTATTTATGGATTCCTTTTTACCGTGTCACATTTACTTTGGTCCTCTATGTATTTAAATGTT

>62952_62952_4_PAX5-KANK1_PAX5_chr9_37002644_ENST00000377853_KANK1_chr9_730049_ENST00000382303_length(amino acids)=654AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACT
NNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGL
KSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISP
DVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTAL
MLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAK

--------------------------------------------------------------
>62952_62952_5_PAX5-KANK1_PAX5_chr9_37002644_ENST00000446742_KANK1_chr9_730049_ENST00000382303_length(transcript)=2637nt_BP=406nt
ATGGATTTAGAGAAAAATTATCCGACTCCTCGGACCAGCAGGACAGGACATGGAGGAGTGAATCAGCTTGGGGGGGTTTTTGTGAATGGA
CGGCCACTCCCGGATGTAGTCCGCCAGAGGATAGTGGAACTTGCTCATCAAGGTGTCAGGCCCTGCGACATCTCCAGGCAGCTTCGGGTC
AGCCATGGTTGTGTCAGCAAAATTCTTGGCAGGATCATCCGGACAAAAGTACAGCAGCCACCCAACCAACCAGTCCCAGCTTCCAGTCAC
AGCATAGTGTCCACTGGCTCCGTGACGCAGGTGTCCTCGGTGAGCACGGATTCGGCCGGCTCGTCGTACTCCATCAGCGGCATCCTGGGC
ATCACGTCCCCCAGCGCCGACACCAACAAGCGCAAGAGAGACGAAGGCAATTATTTGGGATATACCTGTAAGTGTGGGGGCCTTCAGTCA
GGAAGTCCCTTAAGCTCCCAGACATCCCAGCCTGAGCAAGAAGTGGGGACCTCAGAAGGAAAGCCAATCAGCAGCCTGGATGCCTTCCCC
ACTCAGGAAGGTACGCTGTCTCCAGTGAACCTGACAGACGACCAGATCGCCGCTGGCCTCTATGCATGTACAAACAATGAAAGTACACTG
AAGTCCATCATGAAGAAGAAAGATGGTAACAAAGATTCAAATGGCGCAAAAAAGAATCTTCAGTTTGTTGGCATTAATGGAGGGTATGAA
ACAACTTCAAGTGATGATTCCAGCTCAGATGAAAGCTCTTCTTCCGAGTCAGATGACGAGTGTGATGTCATTGAGTATCCTCTTGAAGAA
GAGGAGGAGGAGGAGGATGAAGACACTCGGGGAATGGCAGAAGGGCACCATGCAGTTAATATTGAAGGTTTGAAGTCTGCCAGGGTGGAA
GATGAAATGCAGGTTCAAGAATGTGAACCTGAGAAGGTGGAAATCAGAGAGAGGTATGAATTAAGTGAAAAGATGTTGTCTGCATGCAAC
TTACTGAAAAATACTATAAATGACCCCAAAGCTTTGACCAGCAAAGATATGAGGTTCTGTCTGAACACCCTCCAGCACGAGTGGTTCCGC
GTGTCCAGTCAGAAGTCAGCCATTCCAGCCATGGTGGGGGACTACATAGCTGCTTTTGAGGCCATTTCCCCAGATGTCCTCCGCTATGTC
ATCAACTTGGCAGACGGCAACGGCAACACAGCCCTCCATTACAGCGTGTCCCACTCCAACTTCGAGATTGTGAAGCTGCTGTTAGATGCC
GATGTGTGTAATGTGGATCACCAGAACAAGGCAGGCTACACCCCCATCATGTTGGCGGCCCTCGCCGCTGTGGAAGCAGAGAAGGACATG
CGGATTGTGGAAGAACTCTTCGGCTGTGGGGATGTGAATGCCAAAGCTAGTCAGGCGGGACAGACGGCCCTCATGCTGGCGGTCAGTCAC
GGACGGATAGACATGGTGAAGGGCCTTCTGGCCTGTGGGGCTGATGTCAACATCCAGGATGACGAGGGCTCCACGGCCCTCATGTGTGCC
AGCGAGCACGGACACGTGGAGATTGTCAAGCTGCTGCTGGCCCAGCCCGGCTGCAACGGTCACCTAGAGGACAACGATGGCAGCACTGCG
CTCTCAATCGCCCTGGAAGCAGGACACAAGGACATCGCTGTTCTTCTGTATGCCCATGTCAACTTTGCAAAAGCCCAGTCTCCGGGCACC
CCTAGGCTTGGAAGGAAGACGTCTCCTGGCCCCACCCACCGAGGTTCATTTGATTGATTGTATGCAAATAGCCCTTTATTTACATGCCAC
TATTAAGCTGCTAATTGTTCCTGTTGGGGTGACAGATACTGAATGTATACGTATTGTGCCTGAGCTCACCAGCAAACAGAAGCATCAAGC
CCAGGGGTAAAGGCTGAAGCTTTCACAGTGCAGAGACTGCTAGCCTGGGCACACACACCTCCTTTCTGGCCGTCTTCTGTGTAGGGCACA
CTTTAACCCAGTCTCTGTTGCTGTTGAGTCTCTGCTCCGTTTTGTACAGTCACAGGGAATTCTGATCTGAAGGGGCACCTTCTGTTCACT
CCCACAAAGTGGTGTCTGGTTCTCACTGAGACGTTTTAAGATTTTTCCACAAATATTTATATGTACTAAATGTGGAACCATTAGAAAGTT
CTTCCAAAATCTCATTCCAGCATAGTTTTGGATTTTTCTTTTGTCTTATTTTAAAATAAGGAAGTCGAGATGACTTTGATCATTGGTAAC
TTGGGCCTGGGCCAGACAAAGTATAAAACTTACAAAAGAATATTCTCATTTGGTCTTAACTAGGTAGATGTAATATATGACTTTTTATAA
AAAGGGTATCTATATGAACTTGACACAGTATTTTCAGCTTTTGTATTCCATACTAAAGCCATGAAGAACTACACGTAACATCATCATTTG
TATTAATTGCACAACTCCAATGCTAAAGGTTGGATTGTGTTAGAGGAATCGGCTCTGTATTTGCCTCTAGAGAAACACAGTGTTCTCTTT
GTATTTATGGATTCCTTTTTACCGTGTCACATTTACTTTGGTCCTCTATGTATTTAAATGTTTGAAGTGCCTTAGACTCTTGCCATATTT

>62952_62952_5_PAX5-KANK1_PAX5_chr9_37002644_ENST00000446742_KANK1_chr9_730049_ENST00000382303_length(amino acids)=588AA_BP=135
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRTKVQQPPNQPVPASSH
SIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFP
TQEGTLSPVNLTDDQIAAGLYACTNNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEE
EEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFR
VSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM
RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTA

--------------------------------------------------------------
>62952_62952_6_PAX5-KANK1_PAX5_chr9_37002644_ENST00000520154_KANK1_chr9_730049_ENST00000382303_length(transcript)=2845nt_BP=614nt
AAAAATCAAAATGGATTTAGAGAAAAATTATCCGACTCCTCGGACCAGCAGGACAGGACATGGAGGAGTGAATCAGCTTGGGGGGGTTTT
TGTGAATGGACGGCCACTCCCGGATGTAGTCCGCCAGAGGATAGTGGAACTTGCTCATCAAGGTGTCAGGCCCTGCGACATCTCCAGGCA
GCTTCGGGTCAGCCATGGTTGTGTCAGCAAAATTCTTGGCAGGTATTATGAGACAGGAAGCATCAAGCCTGGGGTAATTGGAGGATCCAA
ACCAAAGGTCGCCACACCCAAAGTGGTGGAAAAAATCGCTGAATATAAACGCCAAAATCCCACCATGTTTGCCTGGGAGATCAGGGACCG
GCTGCTGGCAGAGCGGGTGTGTGACAATGACACCGTGCCTAGCGTCAGTTCCATCAACAGGATCATCCGGACAAAAGTACAGCAGCCACC
CAACCAACCAGTCCCAGCTTCCAGTCACAGCATAGTGTCCACTGGCTCCGTGACGCAGGTGTCCTCGGTGAGCACGGATTCGGCCGGCTC
GTCGTACTCCATCAGCGGCATCCTGGGCATCACGTCCCCCAGCGCCGACACCAACAAGCGCAAGAGAGACGAAGGCAATTATTTGGGATA
TACCTGTAAGTGTGGGGGCCTTCAGTCAGGAAGTCCCTTAAGCTCCCAGACATCCCAGCCTGAGCAAGAAGTGGGGACCTCAGAAGGAAA
GCCAATCAGCAGCCTGGATGCCTTCCCCACTCAGGAAGGTACGCTGTCTCCAGTGAACCTGACAGACGACCAGATCGCCGCTGGCCTCTA
TGCATGTACAAACAATGAAAGTACACTGAAGTCCATCATGAAGAAGAAAGATGGTAACAAAGATTCAAATGGCGCAAAAAAGAATCTTCA
GTTTGTTGGCATTAATGGAGGGTATGAAACAACTTCAAGTGATGATTCCAGCTCAGATGAAAGCTCTTCTTCCGAGTCAGATGACGAGTG
TGATGTCATTGAGTATCCTCTTGAAGAAGAGGAGGAGGAGGAGGATGAAGACACTCGGGGAATGGCAGAAGGGCACCATGCAGTTAATAT
TGAAGGTTTGAAGTCTGCCAGGGTGGAAGATGAAATGCAGGTTCAAGAATGTGAACCTGAGAAGGTGGAAATCAGAGAGAGGTATGAATT
AAGTGAAAAGATGTTGTCTGCATGCAACTTACTGAAAAATACTATAAATGACCCCAAAGCTTTGACCAGCAAAGATATGAGGTTCTGTCT
GAACACCCTCCAGCACGAGTGGTTCCGCGTGTCCAGTCAGAAGTCAGCCATTCCAGCCATGGTGGGGGACTACATAGCTGCTTTTGAGGC
CATTTCCCCAGATGTCCTCCGCTATGTCATCAACTTGGCAGACGGCAACGGCAACACAGCCCTCCATTACAGCGTGTCCCACTCCAACTT
CGAGATTGTGAAGCTGCTGTTAGATGCCGATGTGTGTAATGTGGATCACCAGAACAAGGCAGGCTACACCCCCATCATGTTGGCGGCCCT
CGCCGCTGTGGAAGCAGAGAAGGACATGCGGATTGTGGAAGAACTCTTCGGCTGTGGGGATGTGAATGCCAAAGCTAGTCAGGCGGGACA
GACGGCCCTCATGCTGGCGGTCAGTCACGGACGGATAGACATGGTGAAGGGCCTTCTGGCCTGTGGGGCTGATGTCAACATCCAGGATGA
CGAGGGCTCCACGGCCCTCATGTGTGCCAGCGAGCACGGACACGTGGAGATTGTCAAGCTGCTGCTGGCCCAGCCCGGCTGCAACGGTCA
CCTAGAGGACAACGATGGCAGCACTGCGCTCTCAATCGCCCTGGAAGCAGGACACAAGGACATCGCTGTTCTTCTGTATGCCCATGTCAA
CTTTGCAAAAGCCCAGTCTCCGGGCACCCCTAGGCTTGGAAGGAAGACGTCTCCTGGCCCCACCCACCGAGGTTCATTTGATTGATTGTA
TGCAAATAGCCCTTTATTTACATGCCACTATTAAGCTGCTAATTGTTCCTGTTGGGGTGACAGATACTGAATGTATACGTATTGTGCCTG
AGCTCACCAGCAAACAGAAGCATCAAGCCCAGGGGTAAAGGCTGAAGCTTTCACAGTGCAGAGACTGCTAGCCTGGGCACACACACCTCC
TTTCTGGCCGTCTTCTGTGTAGGGCACACTTTAACCCAGTCTCTGTTGCTGTTGAGTCTCTGCTCCGTTTTGTACAGTCACAGGGAATTC
TGATCTGAAGGGGCACCTTCTGTTCACTCCCACAAAGTGGTGTCTGGTTCTCACTGAGACGTTTTAAGATTTTTCCACAAATATTTATAT
GTACTAAATGTGGAACCATTAGAAAGTTCTTCCAAAATCTCATTCCAGCATAGTTTTGGATTTTTCTTTTGTCTTATTTTAAAATAAGGA
AGTCGAGATGACTTTGATCATTGGTAACTTGGGCCTGGGCCAGACAAAGTATAAAACTTACAAAAGAATATTCTCATTTGGTCTTAACTA
GGTAGATGTAATATATGACTTTTTATAAAAAGGGTATCTATATGAACTTGACACAGTATTTTCAGCTTTTGTATTCCATACTAAAGCCAT
GAAGAACTACACGTAACATCATCATTTGTATTAATTGCACAACTCCAATGCTAAAGGTTGGATTGTGTTAGAGGAATCGGCTCTGTATTT
GCCTCTAGAGAAACACAGTGTTCTCTTTGTATTTATGGATTCCTTTTTACCGTGTCACATTTACTTTGGTCCTCTATGTATTTAAATGTT

>62952_62952_6_PAX5-KANK1_PAX5_chr9_37002644_ENST00000520154_KANK1_chr9_730049_ENST00000382303_length(amino acids)=654AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACT
NNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGL
KSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISP
DVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTAL
MLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAK

--------------------------------------------------------------
>62952_62952_7_PAX5-KANK1_PAX5_chr9_37002644_ENST00000523241_KANK1_chr9_730049_ENST00000382303_length(transcript)=2845nt_BP=614nt
AAAAATCAAAATGGATTTAGAGAAAAATTATCCGACTCCTCGGACCAGCAGGACAGGACATGGAGGAGTGAATCAGCTTGGGGGGGTTTT
TGTGAATGGACGGCCACTCCCGGATGTAGTCCGCCAGAGGATAGTGGAACTTGCTCATCAAGGTGTCAGGCCCTGCGACATCTCCAGGCA
GCTTCGGGTCAGCCATGGTTGTGTCAGCAAAATTCTTGGCAGGTATTATGAGACAGGAAGCATCAAGCCTGGGGTAATTGGAGGATCCAA
ACCAAAGGTCGCCACACCCAAAGTGGTGGAAAAAATCGCTGAATATAAACGCCAAAATCCCACCATGTTTGCCTGGGAGATCAGGGACCG
GCTGCTGGCAGAGCGGGTGTGTGACAATGACACCGTGCCTAGCGTCAGTTCCATCAACAGGATCATCCGGACAAAAGTACAGCAGCCACC
CAACCAACCAGTCCCAGCTTCCAGTCACAGCATAGTGTCCACTGGCTCCGTGACGCAGGTGTCCTCGGTGAGCACGGATTCGGCCGGCTC
GTCGTACTCCATCAGCGGCATCCTGGGCATCACGTCCCCCAGCGCCGACACCAACAAGCGCAAGAGAGACGAAGGCAATTATTTGGGATA
TACCTGTAAGTGTGGGGGCCTTCAGTCAGGAAGTCCCTTAAGCTCCCAGACATCCCAGCCTGAGCAAGAAGTGGGGACCTCAGAAGGAAA
GCCAATCAGCAGCCTGGATGCCTTCCCCACTCAGGAAGGTACGCTGTCTCCAGTGAACCTGACAGACGACCAGATCGCCGCTGGCCTCTA
TGCATGTACAAACAATGAAAGTACACTGAAGTCCATCATGAAGAAGAAAGATGGTAACAAAGATTCAAATGGCGCAAAAAAGAATCTTCA
GTTTGTTGGCATTAATGGAGGGTATGAAACAACTTCAAGTGATGATTCCAGCTCAGATGAAAGCTCTTCTTCCGAGTCAGATGACGAGTG
TGATGTCATTGAGTATCCTCTTGAAGAAGAGGAGGAGGAGGAGGATGAAGACACTCGGGGAATGGCAGAAGGGCACCATGCAGTTAATAT
TGAAGGTTTGAAGTCTGCCAGGGTGGAAGATGAAATGCAGGTTCAAGAATGTGAACCTGAGAAGGTGGAAATCAGAGAGAGGTATGAATT
AAGTGAAAAGATGTTGTCTGCATGCAACTTACTGAAAAATACTATAAATGACCCCAAAGCTTTGACCAGCAAAGATATGAGGTTCTGTCT
GAACACCCTCCAGCACGAGTGGTTCCGCGTGTCCAGTCAGAAGTCAGCCATTCCAGCCATGGTGGGGGACTACATAGCTGCTTTTGAGGC
CATTTCCCCAGATGTCCTCCGCTATGTCATCAACTTGGCAGACGGCAACGGCAACACAGCCCTCCATTACAGCGTGTCCCACTCCAACTT
CGAGATTGTGAAGCTGCTGTTAGATGCCGATGTGTGTAATGTGGATCACCAGAACAAGGCAGGCTACACCCCCATCATGTTGGCGGCCCT
CGCCGCTGTGGAAGCAGAGAAGGACATGCGGATTGTGGAAGAACTCTTCGGCTGTGGGGATGTGAATGCCAAAGCTAGTCAGGCGGGACA
GACGGCCCTCATGCTGGCGGTCAGTCACGGACGGATAGACATGGTGAAGGGCCTTCTGGCCTGTGGGGCTGATGTCAACATCCAGGATGA
CGAGGGCTCCACGGCCCTCATGTGTGCCAGCGAGCACGGACACGTGGAGATTGTCAAGCTGCTGCTGGCCCAGCCCGGCTGCAACGGTCA
CCTAGAGGACAACGATGGCAGCACTGCGCTCTCAATCGCCCTGGAAGCAGGACACAAGGACATCGCTGTTCTTCTGTATGCCCATGTCAA
CTTTGCAAAAGCCCAGTCTCCGGGCACCCCTAGGCTTGGAAGGAAGACGTCTCCTGGCCCCACCCACCGAGGTTCATTTGATTGATTGTA
TGCAAATAGCCCTTTATTTACATGCCACTATTAAGCTGCTAATTGTTCCTGTTGGGGTGACAGATACTGAATGTATACGTATTGTGCCTG
AGCTCACCAGCAAACAGAAGCATCAAGCCCAGGGGTAAAGGCTGAAGCTTTCACAGTGCAGAGACTGCTAGCCTGGGCACACACACCTCC
TTTCTGGCCGTCTTCTGTGTAGGGCACACTTTAACCCAGTCTCTGTTGCTGTTGAGTCTCTGCTCCGTTTTGTACAGTCACAGGGAATTC
TGATCTGAAGGGGCACCTTCTGTTCACTCCCACAAAGTGGTGTCTGGTTCTCACTGAGACGTTTTAAGATTTTTCCACAAATATTTATAT
GTACTAAATGTGGAACCATTAGAAAGTTCTTCCAAAATCTCATTCCAGCATAGTTTTGGATTTTTCTTTTGTCTTATTTTAAAATAAGGA
AGTCGAGATGACTTTGATCATTGGTAACTTGGGCCTGGGCCAGACAAAGTATAAAACTTACAAAAGAATATTCTCATTTGGTCTTAACTA
GGTAGATGTAATATATGACTTTTTATAAAAAGGGTATCTATATGAACTTGACACAGTATTTTCAGCTTTTGTATTCCATACTAAAGCCAT
GAAGAACTACACGTAACATCATCATTTGTATTAATTGCACAACTCCAATGCTAAAGGTTGGATTGTGTTAGAGGAATCGGCTCTGTATTT
GCCTCTAGAGAAACACAGTGTTCTCTTTGTATTTATGGATTCCTTTTTACCGTGTCACATTTACTTTGGTCCTCTATGTATTTAAATGTT

>62952_62952_7_PAX5-KANK1_PAX5_chr9_37002644_ENST00000523241_KANK1_chr9_730049_ENST00000382303_length(amino acids)=654AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACT
NNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGL
KSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISP
DVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTAL
MLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAK

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Fusion Gene PPI Analysis for PAX5-KANK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PAX5-KANK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PAX5-KANK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource