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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PAXBP1-TP53I3 (FusionGDB2 ID:62983)

Fusion Gene Summary for PAXBP1-TP53I3

Fusion gene summary

Fusion gene information	Fusion gene name: PAXBP1-TP53I3
	Fusion gene ID: 62983
		Hgene	Tgene
	Gene symbol	PAXBP1	TP53I3
	Gene ID	94104	9540
	Gene name	PAX3 and PAX7 binding protein 1	tumor protein p53 inducible protein 3
	Synonyms	BM020\|C21orf66\|FSAP105\|GCFC\|GCFC1	PIG3
	Cytomap	21q22.11	2p23.3
	Type of gene	protein-coding	protein-coding
	Description	PAX3- and PAX7-binding protein 1GC-rich sequence DNA-binding factor 1GC-rich sequence DNA-binding factor candidatefunctional spliceosome-associated protein 105	quinone oxidoreductase PIG3p53-induced gene 3 proteinquinone oxidoreductase homolog
	Modification date	20200313	20200313
	UniProtAcc	Q9Y5B6	.
	Ensembl transtripts involved in fusion gene	ENST00000290178, ENST00000331923, ENST00000472588,	ENST00000417886, ENST00000238721, ENST00000313482, ENST00000335934, ENST00000407482,
Fusion gene scores	* DoF score	4 X 4 X 2=32	3 X 2 X 2=12
	# samples	4	3
	** MAII score	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: PAXBP1 [Title/Abstract] AND TP53I3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PAXBP1(34131391)-TP53I3(24300631), # samples:2
Anticipated loss of major functional domain due to fusion event.	PAXBP1-TP53I3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TP53I3	GO:0006739	NADP metabolic process	19349281

Fusion gene breakpoints across PAXBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TP53I3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AR-A1AO-01A	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-

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Fusion Gene ORF analysis for PAXBP1-TP53I3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000290178	ENST00000417886	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-
5CDS-intron	ENST00000331923	ENST00000417886	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-
5UTR-3CDS	ENST00000472588	ENST00000238721	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-
5UTR-3CDS	ENST00000472588	ENST00000313482	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-
5UTR-3CDS	ENST00000472588	ENST00000335934	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-
5UTR-3CDS	ENST00000472588	ENST00000407482	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-
5UTR-intron	ENST00000472588	ENST00000417886	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-
Frame-shift	ENST00000290178	ENST00000238721	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-
Frame-shift	ENST00000290178	ENST00000335934	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-
Frame-shift	ENST00000331923	ENST00000238721	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-
Frame-shift	ENST00000331923	ENST00000335934	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-
In-frame	ENST00000290178	ENST00000313482	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-
In-frame	ENST00000290178	ENST00000407482	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-
In-frame	ENST00000331923	ENST00000313482	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-
In-frame	ENST00000331923	ENST00000407482	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000331923	PAXBP1	chr21	34131391	-	ENST00000313482	TP53I3	chr2	24300631	-	1899	1573	136	1755	539
ENST00000331923	PAXBP1	chr21	34131391	-	ENST00000407482	TP53I3	chr2	24300631	-	1701	1573	136	1698	521
ENST00000290178	PAXBP1	chr21	34131391	-	ENST00000313482	TP53I3	chr2	24300631	-	1709	1383	0	1565	521
ENST00000290178	PAXBP1	chr21	34131391	-	ENST00000407482	TP53I3	chr2	24300631	-	1511	1383	0	1508	503

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000331923	ENST00000313482	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-	0.002390115	0.99760985
ENST00000331923	ENST00000407482	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-	0.34382814	0.6561719
ENST00000290178	ENST00000313482	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-	0.001900952	0.998099
ENST00000290178	ENST00000407482	PAXBP1	chr21	34131391	-	TP53I3	chr2	24300631	-	0.18099852	0.8190015

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Fusion Genomic Features for PAXBP1-TP53I3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PAXBP1-TP53I3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:34131391/chr2:24300631)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PAXBP1 Q9Y5B6	.
FUNCTION: Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TP53I3

chr21:34131391

chr2:24300631

ENST00000313482

264_266

206

249.0

Nucleotide binding

NADP

Tgene

TP53I3

chr21:34131391

chr2:24300631

ENST00000407482

264_266

206

249.0

Nucleotide binding

NADP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TP53I3

chr21:34131391

chr2:24300631

ENST00000238721

148_154

272

333.0

Nucleotide binding

NADP

Tgene

TP53I3

chr21:34131391

chr2:24300631

ENST00000238721

173_177

272

333.0

Nucleotide binding

NADP

Tgene

TP53I3

chr21:34131391

chr2:24300631

ENST00000238721

264_266

272

333.0

Nucleotide binding

NADP

Tgene

TP53I3

chr21:34131391

chr2:24300631

ENST00000313482

148_154

206

249.0

Nucleotide binding

NADP

Tgene

TP53I3

chr21:34131391

chr2:24300631

ENST00000313482

173_177

206

249.0

Nucleotide binding

NADP

Tgene

TP53I3

chr21:34131391

chr2:24300631

ENST00000335934

148_154

272

333.0

Nucleotide binding

NADP

Tgene

TP53I3

chr21:34131391

chr2:24300631

ENST00000335934

173_177

272

333.0

Nucleotide binding

NADP

Tgene

TP53I3

chr21:34131391

chr2:24300631

ENST00000335934

264_266

272

333.0

Nucleotide binding

NADP

Tgene

TP53I3

chr21:34131391

chr2:24300631

ENST00000407482

148_154

206

249.0

Nucleotide binding

NADP

Tgene

TP53I3

chr21:34131391

chr2:24300631

ENST00000407482

173_177

206

249.0

Nucleotide binding

NADP

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Fusion Gene Sequence for PAXBP1-TP53I3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>62983_62983_1_PAXBP1-TP53I3_PAXBP1_chr21_34131391_ENST00000290178_TP53I3_chr2_24300631_ENST00000313482_length(transcript)=1709nt_BP=1383nt
ATGTTCCGAAAGGCCCGGCGGGTGAACGTGCGCAAGCGGAACGACTCCGAAGAGGAAGAGCGGGAACGCGATGAGGAGCAGGAGCCGCCG
CCGTTGTTGCCGCCGCCGGGCACGGGCGAAGAGGCGGGCCCCGGTGGCGGCGACAGGGCCCCTGGCGGGGAGTCGCTGCTGGGCCCGGGG
CCGTCGCCGCCTTCCGCGCTGACCCCGGGCCTCGGGGCTGAGGCCGGGGGCGGCTTCCCCGGCGGCGCGGAGCCCGGCAACGGGCTGAAG
CCGCGCAAGAGGCCTCGCGAGAACAAAGAGGTGCCCCGGGCCAGCCTGCTCAGCTTCCAGGACGAGGAGGAAGAAAATGAAGAAGTTTTC
AAAGTGAAGAAATCAAGTTATAGCAAAAAGATAGTAAAATTGCTCAAGAAGGAATATAAAGAAGATCTTGAAAAATCGAAGATTAAGACA
GAACTCAACTCATCAGCTGAAAGTGAACAACCTTTGGACAAAACAGGACATGTTAAGGATACAAATCAAGAAGATGGAGTTATCATCAGT
GAACATGGTGAAGATGAAATGGATATGGAAAGTGAAAAAGAGGAAGAAAAGCCAAAGACTGGTGGAGCTTTTTCAAATGCTTTATCTTCA
TTGAATGTTCTTCGTCCAGGAGAAATTCCAGATGCAGCTTTTATACATGCTGCAAGGAAAAAGCGCCAAATGGCCCGAGAATTGGGAGAT
TTCACTCCTCATGATAATGAGCCTGGTAAAGGCCGCCTTGTTAGAGAAGATGAGAATGATGCCAGTGATGATGAAGATGACGATGAGAAA
CGCCGGATAGTTTTTTCTGTGAAAGAAAAGTCACAAAGACAAAAAATTGCTGAGGAAATAGGAATTGAGGGGAGTGATGATGATGCTTTA
GTAACTGGAGAACAGGATGAAGAGCTCAGCCGATGGGAACAGGAGCAGATAAGGAAAGGAATTAATATCCCTCAGGTTCAAGCCAGTCAA
CCCGCAGAAGTGAATATGTACTACCAGAACACTTACCAGACAATGCCTTACGGCTCATCCTATGGCATTCCTTATAGTTATACGGCCTAT
GGATCATCAGATGCCAAATCTCAAAAAACAGATAATACAGTCCCTTTCAAAACTCCCAGTAATGAGATGACTCCCGTTACTATTGATTTG
GTAAAGAAACAGCTTAAAGACAGGTTGGACTCCATGAAAGAATTGCACAAAACAAATCGACAGCAGCATGAGAAACATCTGCAAAGCCGA
GTGGACTCTACCAGGGCTATTGAAAGATTAGAAGGGTCTTCTGGGGGTATTGGTGAACGGTATAAATTTTTGCAAGAAATGCGAGGGTAT
GTCCAAGACTTGCTTGAGTGTTTCAGTGAAAAGTACAAGCAAATGCTGGTGAATGCTTTCACGGAGCAAATTCTGCCTCACTTCTCCACG
GAGGGCCCCCAACGTCTGCTGCCGGTTCTGGACAGAATCTACCCAGTGACCGAAATCCAGGAGGCCCATAAGTACATGGAGGCCAACAAG
AACATAGGCAAGATCGTCCTGGAACTGCCCCAGTGAAGGAGGATGGGGCAGGACAGGACGCGGCCACCCCAGGCCTTTCCAGAGCAAACC

>62983_62983_1_PAXBP1-TP53I3_PAXBP1_chr21_34131391_ENST00000290178_TP53I3_chr2_24300631_ENST00000313482_length(amino acids)=521AA_BP=461
MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPGTGEEAGPGGGDRAPGGESLLGPGPSPPSALTPGLGAEAGGGFPGGAEPGNGLK
PRKRPRENKEVPRASLLSFQDEEEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNSSAESEQPLDKTGHVKDTNQEDGVIIS
EHGEDEMDMESEKEEEKPKTGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARELGDFTPHDNEPGKGRLVREDENDASDDEDDDEK
RRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPAEVNMYYQNTYQTMPYGSSYGIPYSYTAY
GSSDAKSQKTDNTVPFKTPSNEMTPVTIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGY

--------------------------------------------------------------
>62983_62983_2_PAXBP1-TP53I3_PAXBP1_chr21_34131391_ENST00000290178_TP53I3_chr2_24300631_ENST00000407482_length(transcript)=1511nt_BP=1383nt
ATGTTCCGAAAGGCCCGGCGGGTGAACGTGCGCAAGCGGAACGACTCCGAAGAGGAAGAGCGGGAACGCGATGAGGAGCAGGAGCCGCCG
CCGTTGTTGCCGCCGCCGGGCACGGGCGAAGAGGCGGGCCCCGGTGGCGGCGACAGGGCCCCTGGCGGGGAGTCGCTGCTGGGCCCGGGG
CCGTCGCCGCCTTCCGCGCTGACCCCGGGCCTCGGGGCTGAGGCCGGGGGCGGCTTCCCCGGCGGCGCGGAGCCCGGCAACGGGCTGAAG
CCGCGCAAGAGGCCTCGCGAGAACAAAGAGGTGCCCCGGGCCAGCCTGCTCAGCTTCCAGGACGAGGAGGAAGAAAATGAAGAAGTTTTC
AAAGTGAAGAAATCAAGTTATAGCAAAAAGATAGTAAAATTGCTCAAGAAGGAATATAAAGAAGATCTTGAAAAATCGAAGATTAAGACA
GAACTCAACTCATCAGCTGAAAGTGAACAACCTTTGGACAAAACAGGACATGTTAAGGATACAAATCAAGAAGATGGAGTTATCATCAGT
GAACATGGTGAAGATGAAATGGATATGGAAAGTGAAAAAGAGGAAGAAAAGCCAAAGACTGGTGGAGCTTTTTCAAATGCTTTATCTTCA
TTGAATGTTCTTCGTCCAGGAGAAATTCCAGATGCAGCTTTTATACATGCTGCAAGGAAAAAGCGCCAAATGGCCCGAGAATTGGGAGAT
TTCACTCCTCATGATAATGAGCCTGGTAAAGGCCGCCTTGTTAGAGAAGATGAGAATGATGCCAGTGATGATGAAGATGACGATGAGAAA
CGCCGGATAGTTTTTTCTGTGAAAGAAAAGTCACAAAGACAAAAAATTGCTGAGGAAATAGGAATTGAGGGGAGTGATGATGATGCTTTA
GTAACTGGAGAACAGGATGAAGAGCTCAGCCGATGGGAACAGGAGCAGATAAGGAAAGGAATTAATATCCCTCAGGTTCAAGCCAGTCAA
CCCGCAGAAGTGAATATGTACTACCAGAACACTTACCAGACAATGCCTTACGGCTCATCCTATGGCATTCCTTATAGTTATACGGCCTAT
GGATCATCAGATGCCAAATCTCAAAAAACAGATAATACAGTCCCTTTCAAAACTCCCAGTAATGAGATGACTCCCGTTACTATTGATTTG
GTAAAGAAACAGCTTAAAGACAGGTTGGACTCCATGAAAGAATTGCACAAAACAAATCGACAGCAGCATGAGAAACATCTGCAAAGCCGA
GTGGACTCTACCAGGGCTATTGAAAGATTAGAAGGGTCTTCTGGGGGTATTGGTGAACGGTATAAATTTTTGCAAGAAATGCGAGGGTAT
GTCCAAGACTTGCTTGAGTGTTTCAGTGAAAAGTACAAGCAAATGCTGGTGAATGCTTTCACGGAGCAAATTCTGCCTCACTTCTCCACG

>62983_62983_2_PAXBP1-TP53I3_PAXBP1_chr21_34131391_ENST00000290178_TP53I3_chr2_24300631_ENST00000407482_length(amino acids)=503AA_BP=461
MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPGTGEEAGPGGGDRAPGGESLLGPGPSPPSALTPGLGAEAGGGFPGGAEPGNGLK
PRKRPRENKEVPRASLLSFQDEEEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNSSAESEQPLDKTGHVKDTNQEDGVIIS
EHGEDEMDMESEKEEEKPKTGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARELGDFTPHDNEPGKGRLVREDENDASDDEDDDEK
RRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPAEVNMYYQNTYQTMPYGSSYGIPYSYTAY
GSSDAKSQKTDNTVPFKTPSNEMTPVTIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGY

--------------------------------------------------------------
>62983_62983_3_PAXBP1-TP53I3_PAXBP1_chr21_34131391_ENST00000331923_TP53I3_chr2_24300631_ENST00000313482_length(transcript)=1899nt_BP=1573nt
CTCTCTCTCTTTCTCCAAGTATTGAGAGCGCGTGGGAGCATAGGCGCATGCGCGCTCGTGGGGTGCGCGGTAGCAACAGAGGACTCGACC
CGGCTGGAGCTCCGGAGAGCGCGCGTGCGCCGTCACGAGCTCGGCGCTGCCGGGGCCGCGGTGTGGAAGCGAGTATTCGACCGCCGTGCG
GGCCGCGGGGATGTTCCGAAAGGCCCGGCGGGTGAACGTGCGCAAGCGGAACGACTCCGAAGAGGAAGAGCGGGAACGCGATGAGGAGCA
GGAGCCGCCGCCGTTGTTGCCGCCGCCGGGCACGGGCGAAGAGGCGGGCCCCGGTGGCGGCGACAGGGCCCCTGGCGGGGAGTCGCTGCT
GGGCCCGGGGCCGTCGCCGCCTTCCGCGCTGACCCCGGGCCTCGGGGCTGAGGCCGGGGGCGGCTTCCCCGGCGGCGCGGAGCCCGGCAA
CGGGCTGAAGCCGCGCAAGAGGCCTCGCGAGAACAAAGAGGTGCCCCGGGCCAGCCTGCTCAGCTTCCAGGACGAGGAGGAAGAAAATGA
AGAAGTTTTCAAAGTGAAGAAATCAAGTTATAGCAAAAAGATAGTAAAATTGCTCAAGAAGGAATATAAAGAAGATCTTGAAAAATCGAA
GATTAAGACAGAACTCAACTCATCAGCTGAAAGTGAACAACCTTTGGACAAAACAGGACATGTTAAGGATACAAATCAAGAAGATGGAGT
TATCATCAGTGAACATGGTGAAGATGAAATGGATATGGAAAGTGAAAAAGAGGAAGAAAAGCCAAAGACTGGTGGAGCTTTTTCAAATGC
TTTATCTTCATTGAATGTTCTTCGTCCAGGAGAAATTCCAGATGCAGCTTTTATACATGCTGCAAGGAAAAAGCGCCAAATGGCCCGAGA
ATTGGGAGATTTCACTCCTCATGATAATGAGCCTGGTAAAGGCCGCCTTGTTAGAGAAGATGAGAATGATGCCAGTGATGATGAAGATGA
CGATGAGAAACGCCGGATAGTTTTTTCTGTGAAAGAAAAGTCACAAAGACAAAAAATTGCTGAGGAAATAGGAATTGAGGGGAGTGATGA
TGATGCTTTAGTAACTGGAGAACAGGATGAAGAGCTCAGCCGATGGGAACAGGAGCAGATAAGGAAAGGAATTAATATCCCTCAGGTTCA
AGCCAGTCAACCCGCAGAAGTGAATATGTACTACCAGAACACTTACCAGACAATGCCTTACGGCTCATCCTATGGCATTCCTTATAGTTA
TACGGCCTATGGATCATCAGATGCCAAATCTCAAAAAACAGATAATACAGTCCCTTTCAAAACTCCCAGTAATGAGATGACTCCCGTTAC
TATTGATTTGGTAAAGAAACAGCTTAAAGACAGGTTGGACTCCATGAAAGAATTGCACAAAACAAATCGACAGCAGCATGAGAAACATCT
GCAAAGCCGAGTGGACTCTACCAGGGCTATTGAAAGATTAGAAGGGTCTTCTGGGGGTATTGGTGAACGGTATAAATTTTTGCAAGAAAT
GCGAGGGTATGTCCAAGACTTGCTTGAGTGTTTCAGTGAAAAGTACAAGCAAATGCTGGTGAATGCTTTCACGGAGCAAATTCTGCCTCA
CTTCTCCACGGAGGGCCCCCAACGTCTGCTGCCGGTTCTGGACAGAATCTACCCAGTGACCGAAATCCAGGAGGCCCATAAGTACATGGA
GGCCAACAAGAACATAGGCAAGATCGTCCTGGAACTGCCCCAGTGAAGGAGGATGGGGCAGGACAGGACGCGGCCACCCCAGGCCTTTCC
AGAGCAAACCTGGAGAAGATTCACAATAGACAGGCCAAGAAACCCGGTGCTTCCTCCAGAGCCGTTTAAAGCTGATATGAGGAAATAAAG

>62983_62983_3_PAXBP1-TP53I3_PAXBP1_chr21_34131391_ENST00000331923_TP53I3_chr2_24300631_ENST00000313482_length(amino acids)=539AA_BP=479
MPGPRCGSEYSTAVRAAGMFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPGTGEEAGPGGGDRAPGGESLLGPGPSPPSALTPGLG
AEAGGGFPGGAEPGNGLKPRKRPRENKEVPRASLLSFQDEEEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNSSAESEQPL
DKTGHVKDTNQEDGVIISEHGEDEMDMESEKEEEKPKTGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARELGDFTPHDNEPGKGR
LVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPAEVNMYYQNTY
QTMPYGSSYGIPYSYTAYGSSDAKSQKTDNTVPFKTPSNEMTPVTIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEG

--------------------------------------------------------------
>62983_62983_4_PAXBP1-TP53I3_PAXBP1_chr21_34131391_ENST00000331923_TP53I3_chr2_24300631_ENST00000407482_length(transcript)=1701nt_BP=1573nt
CTCTCTCTCTTTCTCCAAGTATTGAGAGCGCGTGGGAGCATAGGCGCATGCGCGCTCGTGGGGTGCGCGGTAGCAACAGAGGACTCGACC
CGGCTGGAGCTCCGGAGAGCGCGCGTGCGCCGTCACGAGCTCGGCGCTGCCGGGGCCGCGGTGTGGAAGCGAGTATTCGACCGCCGTGCG
GGCCGCGGGGATGTTCCGAAAGGCCCGGCGGGTGAACGTGCGCAAGCGGAACGACTCCGAAGAGGAAGAGCGGGAACGCGATGAGGAGCA
GGAGCCGCCGCCGTTGTTGCCGCCGCCGGGCACGGGCGAAGAGGCGGGCCCCGGTGGCGGCGACAGGGCCCCTGGCGGGGAGTCGCTGCT
GGGCCCGGGGCCGTCGCCGCCTTCCGCGCTGACCCCGGGCCTCGGGGCTGAGGCCGGGGGCGGCTTCCCCGGCGGCGCGGAGCCCGGCAA
CGGGCTGAAGCCGCGCAAGAGGCCTCGCGAGAACAAAGAGGTGCCCCGGGCCAGCCTGCTCAGCTTCCAGGACGAGGAGGAAGAAAATGA
AGAAGTTTTCAAAGTGAAGAAATCAAGTTATAGCAAAAAGATAGTAAAATTGCTCAAGAAGGAATATAAAGAAGATCTTGAAAAATCGAA
GATTAAGACAGAACTCAACTCATCAGCTGAAAGTGAACAACCTTTGGACAAAACAGGACATGTTAAGGATACAAATCAAGAAGATGGAGT
TATCATCAGTGAACATGGTGAAGATGAAATGGATATGGAAAGTGAAAAAGAGGAAGAAAAGCCAAAGACTGGTGGAGCTTTTTCAAATGC
TTTATCTTCATTGAATGTTCTTCGTCCAGGAGAAATTCCAGATGCAGCTTTTATACATGCTGCAAGGAAAAAGCGCCAAATGGCCCGAGA
ATTGGGAGATTTCACTCCTCATGATAATGAGCCTGGTAAAGGCCGCCTTGTTAGAGAAGATGAGAATGATGCCAGTGATGATGAAGATGA
CGATGAGAAACGCCGGATAGTTTTTTCTGTGAAAGAAAAGTCACAAAGACAAAAAATTGCTGAGGAAATAGGAATTGAGGGGAGTGATGA
TGATGCTTTAGTAACTGGAGAACAGGATGAAGAGCTCAGCCGATGGGAACAGGAGCAGATAAGGAAAGGAATTAATATCCCTCAGGTTCA
AGCCAGTCAACCCGCAGAAGTGAATATGTACTACCAGAACACTTACCAGACAATGCCTTACGGCTCATCCTATGGCATTCCTTATAGTTA
TACGGCCTATGGATCATCAGATGCCAAATCTCAAAAAACAGATAATACAGTCCCTTTCAAAACTCCCAGTAATGAGATGACTCCCGTTAC
TATTGATTTGGTAAAGAAACAGCTTAAAGACAGGTTGGACTCCATGAAAGAATTGCACAAAACAAATCGACAGCAGCATGAGAAACATCT
GCAAAGCCGAGTGGACTCTACCAGGGCTATTGAAAGATTAGAAGGGTCTTCTGGGGGTATTGGTGAACGGTATAAATTTTTGCAAGAAAT
GCGAGGGTATGTCCAAGACTTGCTTGAGTGTTTCAGTGAAAAGTACAAGCAAATGCTGGTGAATGCTTTCACGGAGCAAATTCTGCCTCA

>62983_62983_4_PAXBP1-TP53I3_PAXBP1_chr21_34131391_ENST00000331923_TP53I3_chr2_24300631_ENST00000407482_length(amino acids)=521AA_BP=479
MPGPRCGSEYSTAVRAAGMFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPGTGEEAGPGGGDRAPGGESLLGPGPSPPSALTPGLG
AEAGGGFPGGAEPGNGLKPRKRPRENKEVPRASLLSFQDEEEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNSSAESEQPL
DKTGHVKDTNQEDGVIISEHGEDEMDMESEKEEEKPKTGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARELGDFTPHDNEPGKGR
LVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPAEVNMYYQNTY
QTMPYGSSYGIPYSYTAYGSSDAKSQKTDNTVPFKTPSNEMTPVTIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEG

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Fusion Gene PPI Analysis for PAXBP1-TP53I3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PAXBP1-TP53I3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PAXBP1-TP53I3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source