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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PBRM1-CACNA2D3 (FusionGDB2 ID:62999)

Fusion Gene Summary for PBRM1-CACNA2D3

check button Fusion gene summary
Fusion gene informationFusion gene name: PBRM1-CACNA2D3
Fusion gene ID: 62999
HgeneTgene
Gene symbol

PBRM1

CACNA2D3

Gene ID

55193

55799

Gene namepolybromo 1calcium voltage-gated channel auxiliary subunit alpha2delta 3
SynonymsBAF180|PB1HSA272268
Cytomap

3p21.1

3p21.1-p14.3

Type of geneprotein-codingprotein-coding
Descriptionprotein polybromo-1BRG1-associated factor 180polybromo-1Dvoltage-dependent calcium channel subunit alpha-2/delta-3calcium channel alpha2-delta3 subunitcalcium channel, voltage-dependent, alpha 2/delta 3 subunitcalcium channel, voltage-dependent, alpha 2/delta subunit 3voltage-gated calcium channel subunit a
Modification date2020031320200313
UniProtAcc.

Q8IZS8

Ensembl transtripts involved in fusion geneENST00000296302, ENST00000337303, 
ENST00000356770, ENST00000394830, 
ENST00000409057, ENST00000409114, 
ENST00000409767, ENST00000410007, 
ENST00000478261, ENST00000288197, 
ENST00000415676, ENST00000474759, 
ENST00000490478, 
Fusion gene scores* DoF score15 X 15 X 10=225016 X 13 X 9=1872
# samples 1916
** MAII scorelog2(19/2250*10)=-3.56585367777345
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1872*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PBRM1 [Title/Abstract] AND CACNA2D3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPBRM1(52637537)-CACNA2D3(54420742), # samples:3
Anticipated loss of major functional domain due to fusion event.PBRM1-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PBRM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CACNA2D3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A1L7-01APBRM1chr3

52637537

-CACNA2D3chr3

54420742

+


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Fusion Gene ORF analysis for PBRM1-CACNA2D3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000296302ENST00000478261PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
5CDS-intronENST00000337303ENST00000478261PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
5CDS-intronENST00000356770ENST00000478261PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
5CDS-intronENST00000394830ENST00000478261PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
5CDS-intronENST00000409057ENST00000478261PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
5CDS-intronENST00000409114ENST00000478261PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
5CDS-intronENST00000409767ENST00000478261PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
5CDS-intronENST00000410007ENST00000478261PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000296302ENST00000288197PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000296302ENST00000415676PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000296302ENST00000474759PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000296302ENST00000490478PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000337303ENST00000288197PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000337303ENST00000415676PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000337303ENST00000474759PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000337303ENST00000490478PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000356770ENST00000288197PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000356770ENST00000415676PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000356770ENST00000474759PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000356770ENST00000490478PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000409057ENST00000288197PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000409057ENST00000415676PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000409057ENST00000474759PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000409057ENST00000490478PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000409114ENST00000288197PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000409114ENST00000415676PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000409114ENST00000474759PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000409114ENST00000490478PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000409767ENST00000288197PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000409767ENST00000415676PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000409767ENST00000474759PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000409767ENST00000490478PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000410007ENST00000288197PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000410007ENST00000415676PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000410007ENST00000474759PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
Frame-shiftENST00000410007ENST00000490478PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
In-frameENST00000394830ENST00000288197PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
In-frameENST00000394830ENST00000415676PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
In-frameENST00000394830ENST00000474759PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+
In-frameENST00000394830ENST00000490478PBRM1chr3

52637537

-CACNA2D3chr3

54420742

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394830PBRM1chr352637537-ENST00000415676CACNA2D3chr354420742+6101287928825833983
ENST00000394830PBRM1chr352637537-ENST00000288197CACNA2D3chr354420742+6181287928825833983
ENST00000394830PBRM1chr352637537-ENST00000474759CACNA2D3chr354420742+6185287928825833983
ENST00000394830PBRM1chr352637537-ENST00000490478CACNA2D3chr354420742+6185287928825833983

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394830ENST00000415676PBRM1chr352637537-CACNA2D3chr354420742+0.0009144730.99908555
ENST00000394830ENST00000288197PBRM1chr352637537-CACNA2D3chr354420742+0.0008428410.9991572
ENST00000394830ENST00000474759PBRM1chr352637537-CACNA2D3chr354420742+0.0008408910.9991591
ENST00000394830ENST00000490478PBRM1chr352637537-CACNA2D3chr354420742+0.0008408910.9991591

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Fusion Genomic Features for PBRM1-CACNA2D3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PBRM1chr352637536-CACNA2D3chr354420741+0.0022679460.99773204
PBRM1chr352637536-CACNA2D3chr354420741+0.0022679460.99773204

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PBRM1-CACNA2D3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52637537/chr3:54420742)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CACNA2D3

Q8IZS8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-1730630_6339261690.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-1728630_6339261583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-1628630_6338941603.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-1830630_6339261583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-1729630_6339261635.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-1830630_6339411653.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-1829630_6339411598.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-1729630_6339261610.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-1730200_2709261690.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-1730400_4709261690.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-1730538_6089261690.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-173064_1349261690.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-1730676_7469261690.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-1730792_8629261690.0DomainBromo 6
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-1728200_2709261583.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-1728400_4709261583.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-1728538_6089261583.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-172864_1349261583.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-1728676_7469261583.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-1728792_8629261583.0DomainBromo 6
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-1628200_2708941603.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-1628400_4708941603.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-1628538_6088941603.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-162864_1348941603.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-1628676_7468941603.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-1628792_8628941603.0DomainBromo 6
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-1830200_2709261583.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-1830400_4709261583.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-1830538_6089261583.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-183064_1349261583.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-1830676_7469261583.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-1830792_8629261583.0DomainBromo 6
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-1729200_2709261635.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-1729400_4709261635.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-1729538_6089261635.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-172964_1349261635.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-1729676_7469261635.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-1729792_8629261635.0DomainBromo 6
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-1830200_2709411653.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-1830400_4709411653.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-1830538_6089411653.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-183064_1349411653.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-1830676_7469411653.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-1830792_8629411653.0DomainBromo 6
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-1829200_2709411598.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-1829400_4709411598.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-1829538_6089411598.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-182964_1349411598.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-1829676_7469411598.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-1829792_8629411598.0DomainBromo 6
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-1729200_2709261610.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-1729400_4709261610.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-1729538_6089261610.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-172964_1349261610.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-1729676_7469261610.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-1729792_8629261610.0DomainBromo 6
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000288197238256_4381071092.0DomainVWFA
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000288197238452_5491071092.0DomainNote=Cache
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000415676339256_4381071092.0DomainVWFA
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000415676339452_5491071092.0DomainNote=Cache
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000474759238256_4381071092.0DomainVWFA
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000474759238452_5491071092.0DomainNote=Cache
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000490478137256_43813998.0DomainVWFA
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000490478137452_54913998.0DomainNote=Cache
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000288197238262_2661071092.0MotifNote=MIDAS-like motif
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000415676339262_2661071092.0MotifNote=MIDAS-like motif
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000474759238262_2661071092.0MotifNote=MIDAS-like motif
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000490478137262_26613998.0MotifNote=MIDAS-like motif
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000002881972381090_10911071092.0Topological domainCytoplasmic
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000004156763391090_10911071092.0Topological domainCytoplasmic
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000004747592381090_10911071092.0Topological domainCytoplasmic
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000004904781371090_109113998.0Topological domainCytoplasmic
TgeneCACNA2D3chr3:52637537chr3:54420742ENST0000049047813729_106813998.0Topological domainExtracellular
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000002881972381069_10891071092.0TransmembraneHelical
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000004156763391069_10891071092.0TransmembraneHelical
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000004747592381069_10891071092.0TransmembraneHelical
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000004904781371069_108913998.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-17301468_15999261690.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-17281468_15999261583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-16281468_15998941603.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-18301468_15999261583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-17291468_15999261635.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-18301468_15999411653.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-18291468_15999411598.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-17291468_15999261610.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-17301379_14479261690.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-17281379_14479261583.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-16281379_14478941603.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-18301379_14479261583.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-17291379_14479261635.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-18301379_14479411653.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-18291379_14479411598.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-17291379_14479261610.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-17301156_12729261690.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-1730956_10749261690.0DomainBAH 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-17281156_12729261583.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-1728956_10749261583.0DomainBAH 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-16281156_12728941603.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-1628956_10748941603.0DomainBAH 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-18301156_12729261583.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-1830956_10749261583.0DomainBAH 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-17291156_12729261635.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-1729956_10749261635.0DomainBAH 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-18301156_12729411653.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-1830956_10749411653.0DomainBAH 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-18291156_12729411598.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-1829956_10749411598.0DomainBAH 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-17291156_12729261610.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-1729956_10749261610.0DomainBAH 1
TgeneCACNA2D3chr3:52637537chr3:54420742ENST0000028819723829_10681071092.0Topological domainExtracellular
TgeneCACNA2D3chr3:52637537chr3:54420742ENST0000041567633929_10681071092.0Topological domainExtracellular
TgeneCACNA2D3chr3:52637537chr3:54420742ENST0000047475923829_10681071092.0Topological domainExtracellular


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Fusion Gene Sequence for PBRM1-CACNA2D3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>62999_62999_1_PBRM1-CACNA2D3_PBRM1_chr3_52637537_ENST00000394830_CACNA2D3_chr3_54420742_ENST00000288197_length(transcript)=6181nt_BP=2879nt
AGGAGCAATAGCAGCAGCCGTGGCGGCCACGGGGCGGGGCGCGGCGGTCGGTGACCGCGGCCGGGGCTGCAGGCGGCGGAGCGGCTGGAA
GTTGGATTCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTC
AACACCAGGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCAT
CCGAGACTATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGT
GGTTTCTCAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCA
GCTTCTTTTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAAC
AAGAAATGAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATC
TTCTCCAGCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACT
TTTTCAGAAACTGCCTTCTAAAGTGCAATATCCAGATTATTATGCAATAATTAAGGAGCCTATAGATCTCAAGACCATTGCCCAGAGGAT
ACAGAATGGAAGCTACAAAAGTATTCATGCAATGGCCAAAGATATAGATCTCCTCGCAAAAAATGCCAAAACTTATAATGAGCCTGGCTC
TCAAGTATTCAAGGATGCAAATTCAATTAAAAAAATATTTTATATGAAAAAGGCTGAAATTGAACATCATGAAATGGCTAAGTCAAGTCT
TCGAATGAGGACTCCATCCAACTTGGCTGCAGCCAGACTGACAGGTCCTTCACACAGTAAAGGCAGCCTTGGTGAAGAGAGAAATCCCAC
TAGCAAGTATTACCGTAATAAAAGAGCAGTACAAGGAGGTCGTTTATCAGCAATTACAATGGCACTTCAATATGGCTCAGAAAGTGAAGA
AGATGCTGCTTTAGCTGCTGCACGCTATGAAGAGGGAGAGTCAGAAGCAGAAAGCATCACTTCCTTTATGGATGTTTCAAATCCTTTTTA
TCAGCTTTATGACACAGTTAGGAGTTGTCGGAATAACCAAGGGCAGCTAATAGCTGAACCTTTTTACCATTTGCCTTCAAAGAAAAAATA
CCCTGATTATTACCAGCAAATTAAAATGCCCATATCACTACAACAGATCCGAACAAAACTGAAGAATCAAGAATATGAAACTTTAGATCA
TTTGGAGTGTGATCTGAATTTAATGTTTGAAAATGCCAAACGCTATAATGTGCCCAATTCAGCCATCTACAAGCGAGTTCTAAAATTGCA
GCAAGTTATGCAGGCAAAGAAGAAAGAGCTTGCCAGGAGAGACGATATCGAGGACGGAGACAGCATGATCTCTTCAGCCACCTCTGATAC
TGGTAGTGCCAAAAGAAAAAGTAAAAAGAACATAAGAAAGCAGCGAATGAAAATCTTATTCAATGTTGTTCTTGAAGCTCGAGAGCCAGG
TTCAGGCAGAAGACTTTGTGACCTATTTATGGTTAAACCATCCAAAAAGGACTATCCTGATTATTATAAAATCATCTTGGAGCCAATGGA
CTTGAAAATAATTGAGCATAACATCCGCAATGACAAATATGCTGGTGAAGAGGGAATGATAGAAGACATGAAGCTGATGTTCCGGAATGC
CAGGCACTATAATGAGGAGGGCTCCCAGGTTTATAATGATGCACATATCCTGGAGAAGTTACTCAAGGAGAAAAGGAAAGAGCTGGGCCC
ACTGCCTGATGATGATGACATGGCTTCTCCCAAACTCAAGCTGAGTAGGAAGAGTGGCATTTCTCCTAAAAAATCAAAATACATGACTCC
AATGCAGCAGAAACTAAATGAGGTCTATGAAGCTGTAAAGAACTATACTGATAAGAGGGGTCGCCGCCTCAGTGCCATATTTCTGAGGCT
TCCCTCTAGATCTGAGTTGCCTGACTACTATCTGACTATTAAAAAGCCCATGGACATGGAAAAAATTCGAAGTCACATGATGGCCAACAA
GTACCAAGATATTGACTCTATGGTTGAGGACTTTGTCATGATGTTTAATAATGCCTGTACATACAATGAGCCGGAGTCTTTGATCTACAA
AGATGCTCTTGTTCTACACAAAGTCCTGCTTGAAACACGCAGAGACCTGGAGGGAGATGAGGACTCTCATGTCCCAAATGTGACTTTGCT
GATTCAAGAGCTTATCCACAATCTTTTTGTGTCAGTCATGAGTCATCAGGATGATGAGGGAAGATGCTACAGCGATTCTTTAGCAGAAAT
TCCTGCTGTGGATCCCAACTTTCCTAACAAACCACCCCTTACATTTGACATAATTAGGAAGAATGTTGAAAATAATCGCTACCGTCGGCT
TGATTTATTTCAAGAGCATATGTTTGAAGTATTGGAACGAGCAAGAAGGATGAATCGGACAGATTCAGAAATATATGAAGATGCAGTAGA
ACTTCAGCAGTTTTTTATTAAAATTCGTGATGAACTCTGCAAAAATGGAGAGATTCTTCTTTCACCGGCACTCAGCTATACCACAAAACA
TTTGCATAATGATGTGGAGAAAGAGAGAAAGGAAAAATTGCCAAAAGAAATAGAGGAAGATAAACTAAAACGAGAAGAAGAAAAAAGAGC
GTCTGGTGGAGGCTGCAGAAGAAGCACACCTGAAACATGAATTTGATGCAGACTTACAGTATGAATACTTCAATGCTGTGCTGATAAATG
AAAGGGACAAAGACGGGAATTTTTTGGAGCTGGGAAAGGAATTCATCTTAGCCCCAAATGACCATTTTAATAATTTGCCTGTGAACATCA
GTCTAAGTGACGTCCAAGTACCAACGAACATGTACAACAAAGACCCTGCAATTGTCAATGGGGTTTATTGGTCTGAATCTCTAAACAAAG
TTTTTGTAGATAACTTTGACCGTGACCCATCTCTCATATGGCAGTACTTTGGAAGTGCAAAGGGCTTTTTTAGGCAGTATCCGGGGATTA
AATGGGAACCAGATGAGAATGGAGTCATTGCCTTCGACTGCAGGAACCGAAAATGGTACATCCAGGCAGCAACTTCTCCGAAAGACGTGG
TCATTTTAGTTGACGTCAGTGGCAGCATGAAAGGACTCCGTCTGACTATCGCGAAGCAAACAGTCTCATCCATTTTGGATACACTTGGGG
ATGATGACTTCTTCAACATAATTGCTTATAATGAGGAGCTTCACTATGTGGAACCTTGCCTGAATGGAACTTTGGTGCAAGCCGACAGGA
CAAACAAAGAGCACTTCAGGGAGCATCTGGACAAACTTTTCGCCAAAGGAATTGGAATGTTGGATATAGCTCTGAATGAGGCCTTCAACA
TTCTGAGTGATTTCAACCACACGGGACAAGGAAGTATCTGCAGTCAGGCCATCATGCTCATAACTGATGGGGCGGTGGACACCTATGATA
CAATCTTTGCAAAATACAATTGGCCAGATCGAAAGGTTCGCATCTTCACATACCTCATTGGACGAGAGGCTGCGTTTGCAGACAATCTAA
AGTGGATGGCCTGTGCCAACAAAGGATTTTTTACCCAGATCTCCACCTTGGCTGATGTGCAGGAGAATGTCATGGAATACCTTCACGTGC
TTAGCCGGCCCAAAGTCATCGACCAGGAGCATGATGTGGTGTGGACCGAAGCTTACATTGACAGCACTCTCCCTCAGGCACAAAAGCTGA
CTGATGATCAGGGCCCCGTCCTGATGACCACTGTAGCCATGCCTGTGTTTAGTAAGCAGAACGAAACCAGATCGAAGGGCATTCTTCTGG
GAGTGGTTGGCACAGATGTCCCAGTGAAAGAACTTCTGAAGACCATCCCCAAATACAAGTTAGGGATTCACGGTTATGCCTTTGCAATCA
CAAATAATGGATATATCCTGACGCATCCGGAACTCAGGCTGCTGTACGAAGAAGGAAAAAAGCGAAGGAAACCTAACTATAGTAGCGTTG
ACCTCTCTGAGGTGGAGTGGGAAGACCGAGATGACGTGTTGAGAAATGCTATGGTGAATCGAAAGACGGGGAAGTTTTCCATGGAGGTGA
AGAAGACAGTGGACAAAGGGAAACGGGTTTTGGTGATGACAAATGACTACTATTATACAGACATCAAGGGTACTCCTTTCAGTTTAGGTG
TGGCGCTTTCCAGAGGTCATGGGAAATATTTCTTCCGAGGGAATGTAACCATCGAAGAAGGCCTGCATGACTTAGAACATCCCGATGTGT
CCTTGGCAGATGAATGGTCCTACTGCAACACTGACCTACACCCTGAGCACCGCCATCTGTCTCAGTTAGAAGCGATTAAGCTCTACCTAA
AAGGCAAAGAACCTCTGCTCCAGTGTGATAAAGAATTGATCCAAGAAGTCCTTTTTGACGCGGTGGTGAGTGCCCCCATTGAAGCGTATT
GGACCAGCCTGGCCCTCAACAAATCTGAAAATTCTGACAAGGGCGTGGAGGTTGCCTTCCTCGGCACTCGCACGGGCCTCTCCAGAATCA
ACCTGTTTGTCGGGGCTGAGCAGCTCACCAATCAGGACTTCCTGAAAGCTGGCGACAAGGAGAACATTTTTAACGCAGACCATTTCCCTC
TCTGGTACCGAAGAGCCGCTGAGCAGATTCCAGGGAGCTTCGTCTACTCGATCCCATTCAGCACTGGACCAGTCAATAAAAGCAATGTGG
TGACAGCAAGTACATCCATCCAGCTCCTGGATGAACGGAAATCTCCTGTGGTGGCAGCTGTAGGCATTCAGATGAAACTTGAATTTTTCC
AAAGGAAGTTCTGGACTGCCAGCAGACAGTGTGCTTCCCTGGATGGCAAATGCTCCATCAGCTGTGATGATGAGACTGTGAATTGTTACC
TCATAGACAATAATGGATTTATTTTGGTGTCTGAAGACTACACACAGACTGGAGACTTTTTTGGTGAGATCGAGGGAGCTGTGATGAACA
AATTGCTAACAATGGGCTCCTTTAAAAGAATTACCCTTTATGACTACCAAGCCATGTGTAGAGCCAACAAGGAAAGCAGCGATGGCGCCC
ATGGCCTCCTGGATCCTTATAATGCCTTCCTCTCTGCAGTAAAATGGATCATGACAGAACTTGTCTTGTTCCTGGTGGAATTTAACCTCT
GCAGTTGGTGGCACTCCGATATGACAGCTAAAGCCCAGAAATTGAAACAGACCCTGGAGCCTTGTGATACTGAATATCCAGCATTCGTCT
CTGAGCGCACCATCAAGGAGACTACAGGGAATATTGCTTGTGAAGACTGCTCCAAGTCCTTTGTCATCCAGCAAATCCCAAGCAGCAACC
TGTTCATGGTGGTGGTGGACAGCAGCTGCCTCTGTGAATCTGTGGCCCCCATCACCATGGCACCCATTGAAATCAGGTATAATGAATCCC
TTAAGTGTGAACGTCTAAAGGCCCAGAAGATCAGAAGGCGCCCAGAATCTTGTCATGGCTTCCATCCTGAGGAGAATGCAAGGGAGTGTG
GGGGTGCGCCGAGTCTCCAAGCCCAGACAGTCCTCCTTCTGCTCCCTCTGCTTTTGATGCTCTTCTCAAGGTGACACTGACTGAGATGTT
CTCTTACTGACTGAGATGTTCTCTTGGCATGCTAAATCATGGATAAACTGTGAACCAAAATATGGTGCAACATACGAGACATGAATATAG
TCCAACCATCAGCATCTCATCATGATTTTAAACTGTGCGTGATATAAACTCTTAAAGATATGTTGACAAAAAGTTATCTATCATCTTTTT
ACTTTGCCAGTCATGCAAATGTGAGTTTGCCACATGATAATCACCCTTCATCAGAAATGGGACCGCAAGTGGTAGGCAGTGTCCCTTCTG

>62999_62999_1_PBRM1-CACNA2D3_PBRM1_chr3_52637537_ENST00000394830_CACNA2D3_chr3_54420742_ENST00000288197_length(amino acids)=983AA_BP=1
MVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKV
FVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGD
DDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDT
IFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLT
DDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVD
LSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVS
LADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRIN
LFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIPFSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQ
RKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAH
GLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNL

--------------------------------------------------------------
>62999_62999_2_PBRM1-CACNA2D3_PBRM1_chr3_52637537_ENST00000394830_CACNA2D3_chr3_54420742_ENST00000415676_length(transcript)=6101nt_BP=2879nt
AGGAGCAATAGCAGCAGCCGTGGCGGCCACGGGGCGGGGCGCGGCGGTCGGTGACCGCGGCCGGGGCTGCAGGCGGCGGAGCGGCTGGAA
GTTGGATTCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTC
AACACCAGGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCAT
CCGAGACTATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGT
GGTTTCTCAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCA
GCTTCTTTTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAAC
AAGAAATGAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATC
TTCTCCAGCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACT
TTTTCAGAAACTGCCTTCTAAAGTGCAATATCCAGATTATTATGCAATAATTAAGGAGCCTATAGATCTCAAGACCATTGCCCAGAGGAT
ACAGAATGGAAGCTACAAAAGTATTCATGCAATGGCCAAAGATATAGATCTCCTCGCAAAAAATGCCAAAACTTATAATGAGCCTGGCTC
TCAAGTATTCAAGGATGCAAATTCAATTAAAAAAATATTTTATATGAAAAAGGCTGAAATTGAACATCATGAAATGGCTAAGTCAAGTCT
TCGAATGAGGACTCCATCCAACTTGGCTGCAGCCAGACTGACAGGTCCTTCACACAGTAAAGGCAGCCTTGGTGAAGAGAGAAATCCCAC
TAGCAAGTATTACCGTAATAAAAGAGCAGTACAAGGAGGTCGTTTATCAGCAATTACAATGGCACTTCAATATGGCTCAGAAAGTGAAGA
AGATGCTGCTTTAGCTGCTGCACGCTATGAAGAGGGAGAGTCAGAAGCAGAAAGCATCACTTCCTTTATGGATGTTTCAAATCCTTTTTA
TCAGCTTTATGACACAGTTAGGAGTTGTCGGAATAACCAAGGGCAGCTAATAGCTGAACCTTTTTACCATTTGCCTTCAAAGAAAAAATA
CCCTGATTATTACCAGCAAATTAAAATGCCCATATCACTACAACAGATCCGAACAAAACTGAAGAATCAAGAATATGAAACTTTAGATCA
TTTGGAGTGTGATCTGAATTTAATGTTTGAAAATGCCAAACGCTATAATGTGCCCAATTCAGCCATCTACAAGCGAGTTCTAAAATTGCA
GCAAGTTATGCAGGCAAAGAAGAAAGAGCTTGCCAGGAGAGACGATATCGAGGACGGAGACAGCATGATCTCTTCAGCCACCTCTGATAC
TGGTAGTGCCAAAAGAAAAAGTAAAAAGAACATAAGAAAGCAGCGAATGAAAATCTTATTCAATGTTGTTCTTGAAGCTCGAGAGCCAGG
TTCAGGCAGAAGACTTTGTGACCTATTTATGGTTAAACCATCCAAAAAGGACTATCCTGATTATTATAAAATCATCTTGGAGCCAATGGA
CTTGAAAATAATTGAGCATAACATCCGCAATGACAAATATGCTGGTGAAGAGGGAATGATAGAAGACATGAAGCTGATGTTCCGGAATGC
CAGGCACTATAATGAGGAGGGCTCCCAGGTTTATAATGATGCACATATCCTGGAGAAGTTACTCAAGGAGAAAAGGAAAGAGCTGGGCCC
ACTGCCTGATGATGATGACATGGCTTCTCCCAAACTCAAGCTGAGTAGGAAGAGTGGCATTTCTCCTAAAAAATCAAAATACATGACTCC
AATGCAGCAGAAACTAAATGAGGTCTATGAAGCTGTAAAGAACTATACTGATAAGAGGGGTCGCCGCCTCAGTGCCATATTTCTGAGGCT
TCCCTCTAGATCTGAGTTGCCTGACTACTATCTGACTATTAAAAAGCCCATGGACATGGAAAAAATTCGAAGTCACATGATGGCCAACAA
GTACCAAGATATTGACTCTATGGTTGAGGACTTTGTCATGATGTTTAATAATGCCTGTACATACAATGAGCCGGAGTCTTTGATCTACAA
AGATGCTCTTGTTCTACACAAAGTCCTGCTTGAAACACGCAGAGACCTGGAGGGAGATGAGGACTCTCATGTCCCAAATGTGACTTTGCT
GATTCAAGAGCTTATCCACAATCTTTTTGTGTCAGTCATGAGTCATCAGGATGATGAGGGAAGATGCTACAGCGATTCTTTAGCAGAAAT
TCCTGCTGTGGATCCCAACTTTCCTAACAAACCACCCCTTACATTTGACATAATTAGGAAGAATGTTGAAAATAATCGCTACCGTCGGCT
TGATTTATTTCAAGAGCATATGTTTGAAGTATTGGAACGAGCAAGAAGGATGAATCGGACAGATTCAGAAATATATGAAGATGCAGTAGA
ACTTCAGCAGTTTTTTATTAAAATTCGTGATGAACTCTGCAAAAATGGAGAGATTCTTCTTTCACCGGCACTCAGCTATACCACAAAACA
TTTGCATAATGATGTGGAGAAAGAGAGAAAGGAAAAATTGCCAAAAGAAATAGAGGAAGATAAACTAAAACGAGAAGAAGAAAAAAGAGC
GTCTGGTGGAGGCTGCAGAAGAAGCACACCTGAAACATGAATTTGATGCAGACTTACAGTATGAATACTTCAATGCTGTGCTGATAAATG
AAAGGGACAAAGACGGGAATTTTTTGGAGCTGGGAAAGGAATTCATCTTAGCCCCAAATGACCATTTTAATAATTTGCCTGTGAACATCA
GTCTAAGTGACGTCCAAGTACCAACGAACATGTACAACAAAGACCCTGCAATTGTCAATGGGGTTTATTGGTCTGAATCTCTAAACAAAG
TTTTTGTAGATAACTTTGACCGTGACCCATCTCTCATATGGCAGTACTTTGGAAGTGCAAAGGGCTTTTTTAGGCAGTATCCGGGGATTA
AATGGGAACCAGATGAGAATGGAGTCATTGCCTTCGACTGCAGGAACCGAAAATGGTACATCCAGGCAGCAACTTCTCCGAAAGACGTGG
TCATTTTAGTTGACGTCAGTGGCAGCATGAAAGGACTCCGTCTGACTATCGCGAAGCAAACAGTCTCATCCATTTTGGATACACTTGGGG
ATGATGACTTCTTCAACATAATTGCTTATAATGAGGAGCTTCACTATGTGGAACCTTGCCTGAATGGAACTTTGGTGCAAGCCGACAGGA
CAAACAAAGAGCACTTCAGGGAGCATCTGGACAAACTTTTCGCCAAAGGAATTGGAATGTTGGATATAGCTCTGAATGAGGCCTTCAACA
TTCTGAGTGATTTCAACCACACGGGACAAGGAAGTATCTGCAGTCAGGCCATCATGCTCATAACTGATGGGGCGGTGGACACCTATGATA
CAATCTTTGCAAAATACAATTGGCCAGATCGAAAGGTTCGCATCTTCACATACCTCATTGGACGAGAGGCTGCGTTTGCAGACAATCTAA
AGTGGATGGCCTGTGCCAACAAAGGATTTTTTACCCAGATCTCCACCTTGGCTGATGTGCAGGAGAATGTCATGGAATACCTTCACGTGC
TTAGCCGGCCCAAAGTCATCGACCAGGAGCATGATGTGGTGTGGACCGAAGCTTACATTGACAGCACTCTCCCTCAGGCACAAAAGCTGA
CTGATGATCAGGGCCCCGTCCTGATGACCACTGTAGCCATGCCTGTGTTTAGTAAGCAGAACGAAACCAGATCGAAGGGCATTCTTCTGG
GAGTGGTTGGCACAGATGTCCCAGTGAAAGAACTTCTGAAGACCATCCCCAAATACAAGTTAGGGATTCACGGTTATGCCTTTGCAATCA
CAAATAATGGATATATCCTGACGCATCCGGAACTCAGGCTGCTGTACGAAGAAGGAAAAAAGCGAAGGAAACCTAACTATAGTAGCGTTG
ACCTCTCTGAGGTGGAGTGGGAAGACCGAGATGACGTGTTGAGAAATGCTATGGTGAATCGAAAGACGGGGAAGTTTTCCATGGAGGTGA
AGAAGACAGTGGACAAAGGGAAACGGGTTTTGGTGATGACAAATGACTACTATTATACAGACATCAAGGGTACTCCTTTCAGTTTAGGTG
TGGCGCTTTCCAGAGGTCATGGGAAATATTTCTTCCGAGGGAATGTAACCATCGAAGAAGGCCTGCATGACTTAGAACATCCCGATGTGT
CCTTGGCAGATGAATGGTCCTACTGCAACACTGACCTACACCCTGAGCACCGCCATCTGTCTCAGTTAGAAGCGATTAAGCTCTACCTAA
AAGGCAAAGAACCTCTGCTCCAGTGTGATAAAGAATTGATCCAAGAAGTCCTTTTTGACGCGGTGGTGAGTGCCCCCATTGAAGCGTATT
GGACCAGCCTGGCCCTCAACAAATCTGAAAATTCTGACAAGGGCGTGGAGGTTGCCTTCCTCGGCACTCGCACGGGCCTCTCCAGAATCA
ACCTGTTTGTCGGGGCTGAGCAGCTCACCAATCAGGACTTCCTGAAAGCTGGCGACAAGGAGAACATTTTTAACGCAGACCATTTCCCTC
TCTGGTACCGAAGAGCCGCTGAGCAGATTCCAGGGAGCTTCGTCTACTCGATCCCATTCAGCACTGGACCAGTCAATAAAAGCAATGTGG
TGACAGCAAGTACATCCATCCAGCTCCTGGATGAACGGAAATCTCCTGTGGTGGCAGCTGTAGGCATTCAGATGAAACTTGAATTTTTCC
AAAGGAAGTTCTGGACTGCCAGCAGACAGTGTGCTTCCCTGGATGGCAAATGCTCCATCAGCTGTGATGATGAGACTGTGAATTGTTACC
TCATAGACAATAATGGATTTATTTTGGTGTCTGAAGACTACACACAGACTGGAGACTTTTTTGGTGAGATCGAGGGAGCTGTGATGAACA
AATTGCTAACAATGGGCTCCTTTAAAAGAATTACCCTTTATGACTACCAAGCCATGTGTAGAGCCAACAAGGAAAGCAGCGATGGCGCCC
ATGGCCTCCTGGATCCTTATAATGCCTTCCTCTCTGCAGTAAAATGGATCATGACAGAACTTGTCTTGTTCCTGGTGGAATTTAACCTCT
GCAGTTGGTGGCACTCCGATATGACAGCTAAAGCCCAGAAATTGAAACAGACCCTGGAGCCTTGTGATACTGAATATCCAGCATTCGTCT
CTGAGCGCACCATCAAGGAGACTACAGGGAATATTGCTTGTGAAGACTGCTCCAAGTCCTTTGTCATCCAGCAAATCCCAAGCAGCAACC
TGTTCATGGTGGTGGTGGACAGCAGCTGCCTCTGTGAATCTGTGGCCCCCATCACCATGGCACCCATTGAAATCAGGTATAATGAATCCC
TTAAGTGTGAACGTCTAAAGGCCCAGAAGATCAGAAGGCGCCCAGAATCTTGTCATGGCTTCCATCCTGAGGAGAATGCAAGGGAGTGTG
GGGGTGCGCCGAGTCTCCAAGCCCAGACAGTCCTCCTTCTGCTCCCTCTGCTTTTGATGCTCTTCTCAAGGTGACACTGACTGAGATGTT
CTCTTACTGACTGAGATGTTCTCTTGGCATGCTAAATCATGGATAAACTGTGAACCAAAATATGGTGCAACATACGAGACATGAATATAG
TCCAACCATCAGCATCTCATCATGATTTTAAACTGTGCGTGATATAAACTCTTAAAGATATGTTGACAAAAAGTTATCTATCATCTTTTT

>62999_62999_2_PBRM1-CACNA2D3_PBRM1_chr3_52637537_ENST00000394830_CACNA2D3_chr3_54420742_ENST00000415676_length(amino acids)=983AA_BP=1
MVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKV
FVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGD
DDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDT
IFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLT
DDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVD
LSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVS
LADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRIN
LFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIPFSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQ
RKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAH
GLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNL

--------------------------------------------------------------
>62999_62999_3_PBRM1-CACNA2D3_PBRM1_chr3_52637537_ENST00000394830_CACNA2D3_chr3_54420742_ENST00000474759_length(transcript)=6185nt_BP=2879nt
AGGAGCAATAGCAGCAGCCGTGGCGGCCACGGGGCGGGGCGCGGCGGTCGGTGACCGCGGCCGGGGCTGCAGGCGGCGGAGCGGCTGGAA
GTTGGATTCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTC
AACACCAGGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCAT
CCGAGACTATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGT
GGTTTCTCAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCA
GCTTCTTTTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAAC
AAGAAATGAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATC
TTCTCCAGCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACT
TTTTCAGAAACTGCCTTCTAAAGTGCAATATCCAGATTATTATGCAATAATTAAGGAGCCTATAGATCTCAAGACCATTGCCCAGAGGAT
ACAGAATGGAAGCTACAAAAGTATTCATGCAATGGCCAAAGATATAGATCTCCTCGCAAAAAATGCCAAAACTTATAATGAGCCTGGCTC
TCAAGTATTCAAGGATGCAAATTCAATTAAAAAAATATTTTATATGAAAAAGGCTGAAATTGAACATCATGAAATGGCTAAGTCAAGTCT
TCGAATGAGGACTCCATCCAACTTGGCTGCAGCCAGACTGACAGGTCCTTCACACAGTAAAGGCAGCCTTGGTGAAGAGAGAAATCCCAC
TAGCAAGTATTACCGTAATAAAAGAGCAGTACAAGGAGGTCGTTTATCAGCAATTACAATGGCACTTCAATATGGCTCAGAAAGTGAAGA
AGATGCTGCTTTAGCTGCTGCACGCTATGAAGAGGGAGAGTCAGAAGCAGAAAGCATCACTTCCTTTATGGATGTTTCAAATCCTTTTTA
TCAGCTTTATGACACAGTTAGGAGTTGTCGGAATAACCAAGGGCAGCTAATAGCTGAACCTTTTTACCATTTGCCTTCAAAGAAAAAATA
CCCTGATTATTACCAGCAAATTAAAATGCCCATATCACTACAACAGATCCGAACAAAACTGAAGAATCAAGAATATGAAACTTTAGATCA
TTTGGAGTGTGATCTGAATTTAATGTTTGAAAATGCCAAACGCTATAATGTGCCCAATTCAGCCATCTACAAGCGAGTTCTAAAATTGCA
GCAAGTTATGCAGGCAAAGAAGAAAGAGCTTGCCAGGAGAGACGATATCGAGGACGGAGACAGCATGATCTCTTCAGCCACCTCTGATAC
TGGTAGTGCCAAAAGAAAAAGTAAAAAGAACATAAGAAAGCAGCGAATGAAAATCTTATTCAATGTTGTTCTTGAAGCTCGAGAGCCAGG
TTCAGGCAGAAGACTTTGTGACCTATTTATGGTTAAACCATCCAAAAAGGACTATCCTGATTATTATAAAATCATCTTGGAGCCAATGGA
CTTGAAAATAATTGAGCATAACATCCGCAATGACAAATATGCTGGTGAAGAGGGAATGATAGAAGACATGAAGCTGATGTTCCGGAATGC
CAGGCACTATAATGAGGAGGGCTCCCAGGTTTATAATGATGCACATATCCTGGAGAAGTTACTCAAGGAGAAAAGGAAAGAGCTGGGCCC
ACTGCCTGATGATGATGACATGGCTTCTCCCAAACTCAAGCTGAGTAGGAAGAGTGGCATTTCTCCTAAAAAATCAAAATACATGACTCC
AATGCAGCAGAAACTAAATGAGGTCTATGAAGCTGTAAAGAACTATACTGATAAGAGGGGTCGCCGCCTCAGTGCCATATTTCTGAGGCT
TCCCTCTAGATCTGAGTTGCCTGACTACTATCTGACTATTAAAAAGCCCATGGACATGGAAAAAATTCGAAGTCACATGATGGCCAACAA
GTACCAAGATATTGACTCTATGGTTGAGGACTTTGTCATGATGTTTAATAATGCCTGTACATACAATGAGCCGGAGTCTTTGATCTACAA
AGATGCTCTTGTTCTACACAAAGTCCTGCTTGAAACACGCAGAGACCTGGAGGGAGATGAGGACTCTCATGTCCCAAATGTGACTTTGCT
GATTCAAGAGCTTATCCACAATCTTTTTGTGTCAGTCATGAGTCATCAGGATGATGAGGGAAGATGCTACAGCGATTCTTTAGCAGAAAT
TCCTGCTGTGGATCCCAACTTTCCTAACAAACCACCCCTTACATTTGACATAATTAGGAAGAATGTTGAAAATAATCGCTACCGTCGGCT
TGATTTATTTCAAGAGCATATGTTTGAAGTATTGGAACGAGCAAGAAGGATGAATCGGACAGATTCAGAAATATATGAAGATGCAGTAGA
ACTTCAGCAGTTTTTTATTAAAATTCGTGATGAACTCTGCAAAAATGGAGAGATTCTTCTTTCACCGGCACTCAGCTATACCACAAAACA
TTTGCATAATGATGTGGAGAAAGAGAGAAAGGAAAAATTGCCAAAAGAAATAGAGGAAGATAAACTAAAACGAGAAGAAGAAAAAAGAGC
GTCTGGTGGAGGCTGCAGAAGAAGCACACCTGAAACATGAATTTGATGCAGACTTACAGTATGAATACTTCAATGCTGTGCTGATAAATG
AAAGGGACAAAGACGGGAATTTTTTGGAGCTGGGAAAGGAATTCATCTTAGCCCCAAATGACCATTTTAATAATTTGCCTGTGAACATCA
GTCTAAGTGACGTCCAAGTACCAACGAACATGTACAACAAAGACCCTGCAATTGTCAATGGGGTTTATTGGTCTGAATCTCTAAACAAAG
TTTTTGTAGATAACTTTGACCGTGACCCATCTCTCATATGGCAGTACTTTGGAAGTGCAAAGGGCTTTTTTAGGCAGTATCCGGGGATTA
AATGGGAACCAGATGAGAATGGAGTCATTGCCTTCGACTGCAGGAACCGAAAATGGTACATCCAGGCAGCAACTTCTCCGAAAGACGTGG
TCATTTTAGTTGACGTCAGTGGCAGCATGAAAGGACTCCGTCTGACTATCGCGAAGCAAACAGTCTCATCCATTTTGGATACACTTGGGG
ATGATGACTTCTTCAACATAATTGCTTATAATGAGGAGCTTCACTATGTGGAACCTTGCCTGAATGGAACTTTGGTGCAAGCCGACAGGA
CAAACAAAGAGCACTTCAGGGAGCATCTGGACAAACTTTTCGCCAAAGGAATTGGAATGTTGGATATAGCTCTGAATGAGGCCTTCAACA
TTCTGAGTGATTTCAACCACACGGGACAAGGAAGTATCTGCAGTCAGGCCATCATGCTCATAACTGATGGGGCGGTGGACACCTATGATA
CAATCTTTGCAAAATACAATTGGCCAGATCGAAAGGTTCGCATCTTCACATACCTCATTGGACGAGAGGCTGCGTTTGCAGACAATCTAA
AGTGGATGGCCTGTGCCAACAAAGGATTTTTTACCCAGATCTCCACCTTGGCTGATGTGCAGGAGAATGTCATGGAATACCTTCACGTGC
TTAGCCGGCCCAAAGTCATCGACCAGGAGCATGATGTGGTGTGGACCGAAGCTTACATTGACAGCACTCTCCCTCAGGCACAAAAGCTGA
CTGATGATCAGGGCCCCGTCCTGATGACCACTGTAGCCATGCCTGTGTTTAGTAAGCAGAACGAAACCAGATCGAAGGGCATTCTTCTGG
GAGTGGTTGGCACAGATGTCCCAGTGAAAGAACTTCTGAAGACCATCCCCAAATACAAGTTAGGGATTCACGGTTATGCCTTTGCAATCA
CAAATAATGGATATATCCTGACGCATCCGGAACTCAGGCTGCTGTACGAAGAAGGAAAAAAGCGAAGGAAACCTAACTATAGTAGCGTTG
ACCTCTCTGAGGTGGAGTGGGAAGACCGAGATGACGTGTTGAGAAATGCTATGGTGAATCGAAAGACGGGGAAGTTTTCCATGGAGGTGA
AGAAGACAGTGGACAAAGGGAAACGGGTTTTGGTGATGACAAATGACTACTATTATACAGACATCAAGGGTACTCCTTTCAGTTTAGGTG
TGGCGCTTTCCAGAGGTCATGGGAAATATTTCTTCCGAGGGAATGTAACCATCGAAGAAGGCCTGCATGACTTAGAACATCCCGATGTGT
CCTTGGCAGATGAATGGTCCTACTGCAACACTGACCTACACCCTGAGCACCGCCATCTGTCTCAGTTAGAAGCGATTAAGCTCTACCTAA
AAGGCAAAGAACCTCTGCTCCAGTGTGATAAAGAATTGATCCAAGAAGTCCTTTTTGACGCGGTGGTGAGTGCCCCCATTGAAGCGTATT
GGACCAGCCTGGCCCTCAACAAATCTGAAAATTCTGACAAGGGCGTGGAGGTTGCCTTCCTCGGCACTCGCACGGGCCTCTCCAGAATCA
ACCTGTTTGTCGGGGCTGAGCAGCTCACCAATCAGGACTTCCTGAAAGCTGGCGACAAGGAGAACATTTTTAACGCAGACCATTTCCCTC
TCTGGTACCGAAGAGCCGCTGAGCAGATTCCAGGGAGCTTCGTCTACTCGATCCCATTCAGCACTGGACCAGTCAATAAAAGCAATGTGG
TGACAGCAAGTACATCCATCCAGCTCCTGGATGAACGGAAATCTCCTGTGGTGGCAGCTGTAGGCATTCAGATGAAACTTGAATTTTTCC
AAAGGAAGTTCTGGACTGCCAGCAGACAGTGTGCTTCCCTGGATGGCAAATGCTCCATCAGCTGTGATGATGAGACTGTGAATTGTTACC
TCATAGACAATAATGGATTTATTTTGGTGTCTGAAGACTACACACAGACTGGAGACTTTTTTGGTGAGATCGAGGGAGCTGTGATGAACA
AATTGCTAACAATGGGCTCCTTTAAAAGAATTACCCTTTATGACTACCAAGCCATGTGTAGAGCCAACAAGGAAAGCAGCGATGGCGCCC
ATGGCCTCCTGGATCCTTATAATGCCTTCCTCTCTGCAGTAAAATGGATCATGACAGAACTTGTCTTGTTCCTGGTGGAATTTAACCTCT
GCAGTTGGTGGCACTCCGATATGACAGCTAAAGCCCAGAAATTGAAACAGACCCTGGAGCCTTGTGATACTGAATATCCAGCATTCGTCT
CTGAGCGCACCATCAAGGAGACTACAGGGAATATTGCTTGTGAAGACTGCTCCAAGTCCTTTGTCATCCAGCAAATCCCAAGCAGCAACC
TGTTCATGGTGGTGGTGGACAGCAGCTGCCTCTGTGAATCTGTGGCCCCCATCACCATGGCACCCATTGAAATCAGGTATAATGAATCCC
TTAAGTGTGAACGTCTAAAGGCCCAGAAGATCAGAAGGCGCCCAGAATCTTGTCATGGCTTCCATCCTGAGGAGAATGCAAGGGAGTGTG
GGGGTGCGCCGAGTCTCCAAGCCCAGACAGTCCTCCTTCTGCTCCCTCTGCTTTTGATGCTCTTCTCAAGGTGACACTGACTGAGATGTT
CTCTTACTGACTGAGATGTTCTCTTGGCATGCTAAATCATGGATAAACTGTGAACCAAAATATGGTGCAACATACGAGACATGAATATAG
TCCAACCATCAGCATCTCATCATGATTTTAAACTGTGCGTGATATAAACTCTTAAAGATATGTTGACAAAAAGTTATCTATCATCTTTTT
ACTTTGCCAGTCATGCAAATGTGAGTTTGCCACATGATAATCACCCTTCATCAGAAATGGGACCGCAAGTGGTAGGCAGTGTCCCTTCTG

>62999_62999_3_PBRM1-CACNA2D3_PBRM1_chr3_52637537_ENST00000394830_CACNA2D3_chr3_54420742_ENST00000474759_length(amino acids)=983AA_BP=1
MVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKV
FVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGD
DDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDT
IFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLT
DDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVD
LSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVS
LADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRIN
LFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIPFSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQ
RKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAH
GLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNL

--------------------------------------------------------------
>62999_62999_4_PBRM1-CACNA2D3_PBRM1_chr3_52637537_ENST00000394830_CACNA2D3_chr3_54420742_ENST00000490478_length(transcript)=6185nt_BP=2879nt
AGGAGCAATAGCAGCAGCCGTGGCGGCCACGGGGCGGGGCGCGGCGGTCGGTGACCGCGGCCGGGGCTGCAGGCGGCGGAGCGGCTGGAA
GTTGGATTCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTC
AACACCAGGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCAT
CCGAGACTATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGT
GGTTTCTCAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCA
GCTTCTTTTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAAC
AAGAAATGAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATC
TTCTCCAGCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACT
TTTTCAGAAACTGCCTTCTAAAGTGCAATATCCAGATTATTATGCAATAATTAAGGAGCCTATAGATCTCAAGACCATTGCCCAGAGGAT
ACAGAATGGAAGCTACAAAAGTATTCATGCAATGGCCAAAGATATAGATCTCCTCGCAAAAAATGCCAAAACTTATAATGAGCCTGGCTC
TCAAGTATTCAAGGATGCAAATTCAATTAAAAAAATATTTTATATGAAAAAGGCTGAAATTGAACATCATGAAATGGCTAAGTCAAGTCT
TCGAATGAGGACTCCATCCAACTTGGCTGCAGCCAGACTGACAGGTCCTTCACACAGTAAAGGCAGCCTTGGTGAAGAGAGAAATCCCAC
TAGCAAGTATTACCGTAATAAAAGAGCAGTACAAGGAGGTCGTTTATCAGCAATTACAATGGCACTTCAATATGGCTCAGAAAGTGAAGA
AGATGCTGCTTTAGCTGCTGCACGCTATGAAGAGGGAGAGTCAGAAGCAGAAAGCATCACTTCCTTTATGGATGTTTCAAATCCTTTTTA
TCAGCTTTATGACACAGTTAGGAGTTGTCGGAATAACCAAGGGCAGCTAATAGCTGAACCTTTTTACCATTTGCCTTCAAAGAAAAAATA
CCCTGATTATTACCAGCAAATTAAAATGCCCATATCACTACAACAGATCCGAACAAAACTGAAGAATCAAGAATATGAAACTTTAGATCA
TTTGGAGTGTGATCTGAATTTAATGTTTGAAAATGCCAAACGCTATAATGTGCCCAATTCAGCCATCTACAAGCGAGTTCTAAAATTGCA
GCAAGTTATGCAGGCAAAGAAGAAAGAGCTTGCCAGGAGAGACGATATCGAGGACGGAGACAGCATGATCTCTTCAGCCACCTCTGATAC
TGGTAGTGCCAAAAGAAAAAGTAAAAAGAACATAAGAAAGCAGCGAATGAAAATCTTATTCAATGTTGTTCTTGAAGCTCGAGAGCCAGG
TTCAGGCAGAAGACTTTGTGACCTATTTATGGTTAAACCATCCAAAAAGGACTATCCTGATTATTATAAAATCATCTTGGAGCCAATGGA
CTTGAAAATAATTGAGCATAACATCCGCAATGACAAATATGCTGGTGAAGAGGGAATGATAGAAGACATGAAGCTGATGTTCCGGAATGC
CAGGCACTATAATGAGGAGGGCTCCCAGGTTTATAATGATGCACATATCCTGGAGAAGTTACTCAAGGAGAAAAGGAAAGAGCTGGGCCC
ACTGCCTGATGATGATGACATGGCTTCTCCCAAACTCAAGCTGAGTAGGAAGAGTGGCATTTCTCCTAAAAAATCAAAATACATGACTCC
AATGCAGCAGAAACTAAATGAGGTCTATGAAGCTGTAAAGAACTATACTGATAAGAGGGGTCGCCGCCTCAGTGCCATATTTCTGAGGCT
TCCCTCTAGATCTGAGTTGCCTGACTACTATCTGACTATTAAAAAGCCCATGGACATGGAAAAAATTCGAAGTCACATGATGGCCAACAA
GTACCAAGATATTGACTCTATGGTTGAGGACTTTGTCATGATGTTTAATAATGCCTGTACATACAATGAGCCGGAGTCTTTGATCTACAA
AGATGCTCTTGTTCTACACAAAGTCCTGCTTGAAACACGCAGAGACCTGGAGGGAGATGAGGACTCTCATGTCCCAAATGTGACTTTGCT
GATTCAAGAGCTTATCCACAATCTTTTTGTGTCAGTCATGAGTCATCAGGATGATGAGGGAAGATGCTACAGCGATTCTTTAGCAGAAAT
TCCTGCTGTGGATCCCAACTTTCCTAACAAACCACCCCTTACATTTGACATAATTAGGAAGAATGTTGAAAATAATCGCTACCGTCGGCT
TGATTTATTTCAAGAGCATATGTTTGAAGTATTGGAACGAGCAAGAAGGATGAATCGGACAGATTCAGAAATATATGAAGATGCAGTAGA
ACTTCAGCAGTTTTTTATTAAAATTCGTGATGAACTCTGCAAAAATGGAGAGATTCTTCTTTCACCGGCACTCAGCTATACCACAAAACA
TTTGCATAATGATGTGGAGAAAGAGAGAAAGGAAAAATTGCCAAAAGAAATAGAGGAAGATAAACTAAAACGAGAAGAAGAAAAAAGAGC
GTCTGGTGGAGGCTGCAGAAGAAGCACACCTGAAACATGAATTTGATGCAGACTTACAGTATGAATACTTCAATGCTGTGCTGATAAATG
AAAGGGACAAAGACGGGAATTTTTTGGAGCTGGGAAAGGAATTCATCTTAGCCCCAAATGACCATTTTAATAATTTGCCTGTGAACATCA
GTCTAAGTGACGTCCAAGTACCAACGAACATGTACAACAAAGACCCTGCAATTGTCAATGGGGTTTATTGGTCTGAATCTCTAAACAAAG
TTTTTGTAGATAACTTTGACCGTGACCCATCTCTCATATGGCAGTACTTTGGAAGTGCAAAGGGCTTTTTTAGGCAGTATCCGGGGATTA
AATGGGAACCAGATGAGAATGGAGTCATTGCCTTCGACTGCAGGAACCGAAAATGGTACATCCAGGCAGCAACTTCTCCGAAAGACGTGG
TCATTTTAGTTGACGTCAGTGGCAGCATGAAAGGACTCCGTCTGACTATCGCGAAGCAAACAGTCTCATCCATTTTGGATACACTTGGGG
ATGATGACTTCTTCAACATAATTGCTTATAATGAGGAGCTTCACTATGTGGAACCTTGCCTGAATGGAACTTTGGTGCAAGCCGACAGGA
CAAACAAAGAGCACTTCAGGGAGCATCTGGACAAACTTTTCGCCAAAGGAATTGGAATGTTGGATATAGCTCTGAATGAGGCCTTCAACA
TTCTGAGTGATTTCAACCACACGGGACAAGGAAGTATCTGCAGTCAGGCCATCATGCTCATAACTGATGGGGCGGTGGACACCTATGATA
CAATCTTTGCAAAATACAATTGGCCAGATCGAAAGGTTCGCATCTTCACATACCTCATTGGACGAGAGGCTGCGTTTGCAGACAATCTAA
AGTGGATGGCCTGTGCCAACAAAGGATTTTTTACCCAGATCTCCACCTTGGCTGATGTGCAGGAGAATGTCATGGAATACCTTCACGTGC
TTAGCCGGCCCAAAGTCATCGACCAGGAGCATGATGTGGTGTGGACCGAAGCTTACATTGACAGCACTCTCCCTCAGGCACAAAAGCTGA
CTGATGATCAGGGCCCCGTCCTGATGACCACTGTAGCCATGCCTGTGTTTAGTAAGCAGAACGAAACCAGATCGAAGGGCATTCTTCTGG
GAGTGGTTGGCACAGATGTCCCAGTGAAAGAACTTCTGAAGACCATCCCCAAATACAAGTTAGGGATTCACGGTTATGCCTTTGCAATCA
CAAATAATGGATATATCCTGACGCATCCGGAACTCAGGCTGCTGTACGAAGAAGGAAAAAAGCGAAGGAAACCTAACTATAGTAGCGTTG
ACCTCTCTGAGGTGGAGTGGGAAGACCGAGATGACGTGTTGAGAAATGCTATGGTGAATCGAAAGACGGGGAAGTTTTCCATGGAGGTGA
AGAAGACAGTGGACAAAGGGAAACGGGTTTTGGTGATGACAAATGACTACTATTATACAGACATCAAGGGTACTCCTTTCAGTTTAGGTG
TGGCGCTTTCCAGAGGTCATGGGAAATATTTCTTCCGAGGGAATGTAACCATCGAAGAAGGCCTGCATGACTTAGAACATCCCGATGTGT
CCTTGGCAGATGAATGGTCCTACTGCAACACTGACCTACACCCTGAGCACCGCCATCTGTCTCAGTTAGAAGCGATTAAGCTCTACCTAA
AAGGCAAAGAACCTCTGCTCCAGTGTGATAAAGAATTGATCCAAGAAGTCCTTTTTGACGCGGTGGTGAGTGCCCCCATTGAAGCGTATT
GGACCAGCCTGGCCCTCAACAAATCTGAAAATTCTGACAAGGGCGTGGAGGTTGCCTTCCTCGGCACTCGCACGGGCCTCTCCAGAATCA
ACCTGTTTGTCGGGGCTGAGCAGCTCACCAATCAGGACTTCCTGAAAGCTGGCGACAAGGAGAACATTTTTAACGCAGACCATTTCCCTC
TCTGGTACCGAAGAGCCGCTGAGCAGATTCCAGGGAGCTTCGTCTACTCGATCCCATTCAGCACTGGACCAGTCAATAAAAGCAATGTGG
TGACAGCAAGTACATCCATCCAGCTCCTGGATGAACGGAAATCTCCTGTGGTGGCAGCTGTAGGCATTCAGATGAAACTTGAATTTTTCC
AAAGGAAGTTCTGGACTGCCAGCAGACAGTGTGCTTCCCTGGATGGCAAATGCTCCATCAGCTGTGATGATGAGACTGTGAATTGTTACC
TCATAGACAATAATGGATTTATTTTGGTGTCTGAAGACTACACACAGACTGGAGACTTTTTTGGTGAGATCGAGGGAGCTGTGATGAACA
AATTGCTAACAATGGGCTCCTTTAAAAGAATTACCCTTTATGACTACCAAGCCATGTGTAGAGCCAACAAGGAAAGCAGCGATGGCGCCC
ATGGCCTCCTGGATCCTTATAATGCCTTCCTCTCTGCAGTAAAATGGATCATGACAGAACTTGTCTTGTTCCTGGTGGAATTTAACCTCT
GCAGTTGGTGGCACTCCGATATGACAGCTAAAGCCCAGAAATTGAAACAGACCCTGGAGCCTTGTGATACTGAATATCCAGCATTCGTCT
CTGAGCGCACCATCAAGGAGACTACAGGGAATATTGCTTGTGAAGACTGCTCCAAGTCCTTTGTCATCCAGCAAATCCCAAGCAGCAACC
TGTTCATGGTGGTGGTGGACAGCAGCTGCCTCTGTGAATCTGTGGCCCCCATCACCATGGCACCCATTGAAATCAGGTATAATGAATCCC
TTAAGTGTGAACGTCTAAAGGCCCAGAAGATCAGAAGGCGCCCAGAATCTTGTCATGGCTTCCATCCTGAGGAGAATGCAAGGGAGTGTG
GGGGTGCGCCGAGTCTCCAAGCCCAGACAGTCCTCCTTCTGCTCCCTCTGCTTTTGATGCTCTTCTCAAGGTGACACTGACTGAGATGTT
CTCTTACTGACTGAGATGTTCTCTTGGCATGCTAAATCATGGATAAACTGTGAACCAAAATATGGTGCAACATACGAGACATGAATATAG
TCCAACCATCAGCATCTCATCATGATTTTAAACTGTGCGTGATATAAACTCTTAAAGATATGTTGACAAAAAGTTATCTATCATCTTTTT
ACTTTGCCAGTCATGCAAATGTGAGTTTGCCACATGATAATCACCCTTCATCAGAAATGGGACCGCAAGTGGTAGGCAGTGTCCCTTCTG

>62999_62999_4_PBRM1-CACNA2D3_PBRM1_chr3_52637537_ENST00000394830_CACNA2D3_chr3_54420742_ENST00000490478_length(amino acids)=983AA_BP=1
MVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKV
FVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGD
DDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDT
IFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLT
DDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVD
LSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVS
LADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRIN
LFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIPFSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQ
RKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAH
GLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PBRM1-CACNA2D3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PBRM1-CACNA2D3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PBRM1-CACNA2D3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource