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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AAK1-NFU1 (FusionGDB2 ID:63)

Fusion Gene Summary for AAK1-NFU1

check button Fusion gene summary
Fusion gene informationFusion gene name: AAK1-NFU1
Fusion gene ID: 63
HgeneTgene
Gene symbol

AAK1

NFU1

Gene ID

112268437

27247

Gene nameuncharacterized protein FLJ45252NFU1 iron-sulfur cluster scaffold
SynonymsAAK1CGI-33|HIRIP|HIRIP5|MMDS1|NIFUC|Nfu|NifU
Cytomap

-

2p13.3

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein FLJ45252alternative protein AAK1NFU1 iron-sulfur cluster scaffold homolog, mitochondrialHIRA-interacting protein 5NifU-like C-terminal domain containingiron-sulfur cluster scaffold protein
Modification date2020030320200313
UniProtAcc

Q2M2I8

Q9UMS0

Ensembl transtripts involved in fusion geneENST00000406297, ENST00000409068, 
ENST00000409085, ENST00000470281, 
ENST00000303698, ENST00000394305, 
ENST00000471185, ENST00000462320, 
ENST00000410022, 
Fusion gene scores* DoF score19 X 13 X 11=27175 X 7 X 6=210
# samples 227
** MAII scorelog2(22/2717*10)=-3.62643913669732
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AAK1 [Title/Abstract] AND NFU1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAAK1(69870010)-NFU1(69650849), # samples:1
AAK1(69870010)-NFU1(69646736), # samples:1
Anticipated loss of major functional domain due to fusion event.AAK1-NFU1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AAK1-NFU1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AAK1-NFU1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
AAK1-NFU1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNFU1

GO:0016226

iron-sulfur cluster assembly

12886008|28906594


check buttonFusion gene breakpoints across AAK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NFU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2791AAK1chr2

69870010

-NFU1chr2

69646736

-
ChimerDB4LUSCTCGA-66-2791AAK1chr2

69870010

-NFU1chr2

69650849

-


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Fusion Gene ORF analysis for AAK1-NFU1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000406297ENST00000303698AAK1chr2

69870010

-NFU1chr2

69646736

-
5CDS-5UTRENST00000406297ENST00000394305AAK1chr2

69870010

-NFU1chr2

69646736

-
5CDS-5UTRENST00000406297ENST00000471185AAK1chr2

69870010

-NFU1chr2

69646736

-
5CDS-5UTRENST00000409068ENST00000303698AAK1chr2

69870010

-NFU1chr2

69646736

-
5CDS-5UTRENST00000409068ENST00000394305AAK1chr2

69870010

-NFU1chr2

69646736

-
5CDS-5UTRENST00000409068ENST00000471185AAK1chr2

69870010

-NFU1chr2

69646736

-
5CDS-5UTRENST00000409085ENST00000303698AAK1chr2

69870010

-NFU1chr2

69646736

-
5CDS-5UTRENST00000409085ENST00000394305AAK1chr2

69870010

-NFU1chr2

69646736

-
5CDS-5UTRENST00000409085ENST00000471185AAK1chr2

69870010

-NFU1chr2

69646736

-
5CDS-intronENST00000406297ENST00000303698AAK1chr2

69870010

-NFU1chr2

69650849

-
5CDS-intronENST00000406297ENST00000394305AAK1chr2

69870010

-NFU1chr2

69650849

-
5CDS-intronENST00000406297ENST00000462320AAK1chr2

69870010

-NFU1chr2

69646736

-
5CDS-intronENST00000406297ENST00000462320AAK1chr2

69870010

-NFU1chr2

69650849

-
5CDS-intronENST00000406297ENST00000471185AAK1chr2

69870010

-NFU1chr2

69650849

-
5CDS-intronENST00000409068ENST00000303698AAK1chr2

69870010

-NFU1chr2

69650849

-
5CDS-intronENST00000409068ENST00000394305AAK1chr2

69870010

-NFU1chr2

69650849

-
5CDS-intronENST00000409068ENST00000462320AAK1chr2

69870010

-NFU1chr2

69646736

-
5CDS-intronENST00000409068ENST00000462320AAK1chr2

69870010

-NFU1chr2

69650849

-
5CDS-intronENST00000409068ENST00000471185AAK1chr2

69870010

-NFU1chr2

69650849

-
5CDS-intronENST00000409085ENST00000303698AAK1chr2

69870010

-NFU1chr2

69650849

-
5CDS-intronENST00000409085ENST00000394305AAK1chr2

69870010

-NFU1chr2

69650849

-
5CDS-intronENST00000409085ENST00000462320AAK1chr2

69870010

-NFU1chr2

69646736

-
5CDS-intronENST00000409085ENST00000462320AAK1chr2

69870010

-NFU1chr2

69650849

-
5CDS-intronENST00000409085ENST00000471185AAK1chr2

69870010

-NFU1chr2

69650849

-
Frame-shiftENST00000406297ENST00000410022AAK1chr2

69870010

-NFU1chr2

69646736

-
Frame-shiftENST00000409068ENST00000410022AAK1chr2

69870010

-NFU1chr2

69646736

-
Frame-shiftENST00000409085ENST00000410022AAK1chr2

69870010

-NFU1chr2

69646736

-
In-frameENST00000406297ENST00000410022AAK1chr2

69870010

-NFU1chr2

69650849

-
In-frameENST00000409068ENST00000410022AAK1chr2

69870010

-NFU1chr2

69650849

-
In-frameENST00000409085ENST00000410022AAK1chr2

69870010

-NFU1chr2

69650849

-
intron-3CDSENST00000470281ENST00000410022AAK1chr2

69870010

-NFU1chr2

69646736

-
intron-3CDSENST00000470281ENST00000410022AAK1chr2

69870010

-NFU1chr2

69650849

-
intron-5UTRENST00000470281ENST00000303698AAK1chr2

69870010

-NFU1chr2

69646736

-
intron-5UTRENST00000470281ENST00000394305AAK1chr2

69870010

-NFU1chr2

69646736

-
intron-5UTRENST00000470281ENST00000471185AAK1chr2

69870010

-NFU1chr2

69646736

-
intron-intronENST00000470281ENST00000303698AAK1chr2

69870010

-NFU1chr2

69650849

-
intron-intronENST00000470281ENST00000394305AAK1chr2

69870010

-NFU1chr2

69650849

-
intron-intronENST00000470281ENST00000462320AAK1chr2

69870010

-NFU1chr2

69646736

-
intron-intronENST00000470281ENST00000462320AAK1chr2

69870010

-NFU1chr2

69650849

-
intron-intronENST00000470281ENST00000471185AAK1chr2

69870010

-NFU1chr2

69650849

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409068AAK1chr269870010-ENST00000410022NFU1chr269650849-15724772151075286
ENST00000409085AAK1chr269870010-ENST00000410022NFU1chr269650849-16355402781138286
ENST00000406297AAK1chr269870010-ENST00000410022NFU1chr269650849-16355402781138286

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409068ENST00000410022AAK1chr269870010-NFU1chr269650849-0.0009338660.9990662
ENST00000409085ENST00000410022AAK1chr269870010-NFU1chr269650849-0.0011282950.9988716
ENST00000406297ENST00000410022AAK1chr269870010-NFU1chr269650849-0.0011282950.9988716

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Fusion Genomic Features for AAK1-NFU1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AAK1-NFU1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:69870010/chr2:69650849)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AAK1

Q2M2I8

NFU1

Q9UMS0

FUNCTION: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:17494869, PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}.FUNCTION: Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins. {ECO:0000269|PubMed:12886008, ECO:0000269|PubMed:27818104, ECO:0000269|PubMed:28906594}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAK1chr2:69870010chr2:69650849ENST00000406297-21812_4254864.0Compositional biasNote=Gly-rich
HgeneAAK1chr2:69870010chr2:69650849ENST00000409085-22212_4254962.0Compositional biasNote=Gly-rich
TgeneNFU1chr2:69870010chr2:69650849ENST0000030369818173_24131231.0RegionNote=NifU
TgeneNFU1chr2:69870010chr2:69650849ENST0000039430507173_2410114.0RegionNote=NifU
TgeneNFU1chr2:69870010chr2:69650849ENST0000041002218173_24155255.0RegionNote=NifU
TgeneNFU1chr2:69870010chr2:69650849ENST0000046232005173_2410114.0RegionNote=NifU

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAK1chr2:69870010chr2:69650849ENST00000406297-218397_61454864.0Compositional biasNote=Gln-rich
HgeneAAK1chr2:69870010chr2:69650849ENST00000406297-218658_66354864.0Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69870010chr2:69650849ENST00000409085-222397_61454962.0Compositional biasNote=Gln-rich
HgeneAAK1chr2:69870010chr2:69650849ENST00000409085-222658_66354962.0Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69870010chr2:69650849ENST00000406297-21846_31554864.0DomainProtein kinase
HgeneAAK1chr2:69870010chr2:69650849ENST00000409085-22246_31554962.0DomainProtein kinase
HgeneAAK1chr2:69870010chr2:69650849ENST00000406297-21852_6054864.0Nucleotide bindingATP
HgeneAAK1chr2:69870010chr2:69650849ENST00000409085-22252_6054962.0Nucleotide bindingATP
HgeneAAK1chr2:69870010chr2:69650849ENST00000406297-218823_96054864.0RegionClathrin-binding domain (CBD)
HgeneAAK1chr2:69870010chr2:69650849ENST00000409085-222823_96054962.0RegionClathrin-binding domain (CBD)


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Fusion Gene Sequence for AAK1-NFU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63_63_1_AAK1-NFU1_AAK1_chr2_69870010_ENST00000406297_NFU1_chr2_69650849_ENST00000410022_length(transcript)=1635nt_BP=540nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
TGAGATACATGTTTATTCAAACACAAGATACCCCAAATCCAAACAGCTTAAAGTTTATACCAGGAAAACCAGTTCTTGAGACAAGGACCA
TGGATTTTCCCACCCCAGCTGCAGCATTTCGCTCCCCTCTGGCTAGGCAGTTATTTAGGATTGAAGGAGTAAAAAGTGTCTTCTTTGGAC
CAGATTTCATCACTGTCACAAAGGAAAATGAAGAATTAGACTGGAATTTACTGAAACCAGATATTTATGCAACAATCATGGACTTCTTTG
CATCTGGCTTACCCCTGGTTACTGAGGAAACACCTTCAGGAGAAGCAGGATCTGAAGAAGATGATGAAGTTGTGGCAATGATTAAGGAAT
TGTTAGATACTAGAATACGGCCAACTGTGCAGGAAGATGGAGGGGATGTAATCTACAAAGGCTTTGAAGATGGCATTGTACAGCTGAAAC
TCCAGGGTTCTTGTACCAGCTGCCCTAGTTCAATCATTACTCTGAAAAATGGAATTCAGAACATGCTGCAGTTTTATATTCCGGAGGTAG
AAGGCGTAGAACAGGTTATGGATGATGAATCAGATGAAAAAGAAGCAAACTCACCTTAAAATAATCTGGATTTTCTTTGGGCATAACAGT
CAGACTTGTTGATAATATATATCAAGTTTTTATTATTAATATGCTGAGGAACTTGAAGATTAATAAAATATGCTCTTCAGAGAATGATAT
ATAAATATTGCATGTTTGCTTTACCTCATATGAGTTATTTATAACCTCTTGAATCATCTTCTGTACACGTGGATTTTATCCAAGGATATT
TTTATTTTTGTCCCTCATTTCCCATGGCTCTTTCTTTGCATATGTGTGAAGGAGTTTAAAATACATTTCCCCCCATCTAATTTATTTACT
TTTTTCCATACAGGAAGAAACAGAATGCTTTTTAGAATATTCTAAAATAGCTTTTTGTGAAATATCTAAAACTATTTTTACTGAAGTTTT
TAGCTTAAGAAACAGCTAAACAAGTCTGTTTTAAAAATGGTATCTGGCTACTAGCCCCCAATTAAGTAGCAAAGAACTGCTTAAGACCAA

>63_63_1_AAK1-NFU1_AAK1_chr2_69870010_ENST00000406297_NFU1_chr2_69650849_ENST00000410022_length(amino acids)=286AA_BP=1
MRRNPWISFLKKKKKKKKSRNHRYFALLLPIRKMKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEVRY
MFIQTQDTPNPNSLKFIPGKPVLETRTMDFPTPAAAFRSPLARQLFRIEGVKSVFFGPDFITVTKENEELDWNLLKPDIYATIMDFFASG
LPLVTEETPSGEAGSEEDDEVVAMIKELLDTRIRPTVQEDGGDVIYKGFEDGIVQLKLQGSCTSCPSSIITLKNGIQNMLQFYIPEVEGV

--------------------------------------------------------------
>63_63_2_AAK1-NFU1_AAK1_chr2_69870010_ENST00000409068_NFU1_chr2_69650849_ENST00000410022_length(transcript)=1572nt_BP=477nt
CTCTGCGTCGCAGGCCGGCCCGGCGGCCGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTT
ACACGAATCGCTTTCTGGAGGAGGAGGGGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCAC
GGCCGGATTCGGGTGGCTCCTCTCCGAGGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAAT
CTAGAAACCATCGGTATTTTGCTTTGCTGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCC
TGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGG
TCACAGTGGACGAGGTGTTGGCGGAAGTGAGATACATGTTTATTCAAACACAAGATACCCCAAATCCAAACAGCTTAAAGTTTATACCAG
GAAAACCAGTTCTTGAGACAAGGACCATGGATTTTCCCACCCCAGCTGCAGCATTTCGCTCCCCTCTGGCTAGGCAGTTATTTAGGATTG
AAGGAGTAAAAAGTGTCTTCTTTGGACCAGATTTCATCACTGTCACAAAGGAAAATGAAGAATTAGACTGGAATTTACTGAAACCAGATA
TTTATGCAACAATCATGGACTTCTTTGCATCTGGCTTACCCCTGGTTACTGAGGAAACACCTTCAGGAGAAGCAGGATCTGAAGAAGATG
ATGAAGTTGTGGCAATGATTAAGGAATTGTTAGATACTAGAATACGGCCAACTGTGCAGGAAGATGGAGGGGATGTAATCTACAAAGGCT
TTGAAGATGGCATTGTACAGCTGAAACTCCAGGGTTCTTGTACCAGCTGCCCTAGTTCAATCATTACTCTGAAAAATGGAATTCAGAACA
TGCTGCAGTTTTATATTCCGGAGGTAGAAGGCGTAGAACAGGTTATGGATGATGAATCAGATGAAAAAGAAGCAAACTCACCTTAAAATA
ATCTGGATTTTCTTTGGGCATAACAGTCAGACTTGTTGATAATATATATCAAGTTTTTATTATTAATATGCTGAGGAACTTGAAGATTAA
TAAAATATGCTCTTCAGAGAATGATATATAAATATTGCATGTTTGCTTTACCTCATATGAGTTATTTATAACCTCTTGAATCATCTTCTG
TACACGTGGATTTTATCCAAGGATATTTTTATTTTTGTCCCTCATTTCCCATGGCTCTTTCTTTGCATATGTGTGAAGGAGTTTAAAATA
CATTTCCCCCCATCTAATTTATTTACTTTTTTCCATACAGGAAGAAACAGAATGCTTTTTAGAATATTCTAAAATAGCTTTTTGTGAAAT
ATCTAAAACTATTTTTACTGAAGTTTTTAGCTTAAGAAACAGCTAAACAAGTCTGTTTTAAAAATGGTATCTGGCTACTAGCCCCCAATT

>63_63_2_AAK1-NFU1_AAK1_chr2_69870010_ENST00000409068_NFU1_chr2_69650849_ENST00000410022_length(amino acids)=286AA_BP=1
MRRNPWISFLKKKKKKKKSRNHRYFALLLPIRKMKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEVRY
MFIQTQDTPNPNSLKFIPGKPVLETRTMDFPTPAAAFRSPLARQLFRIEGVKSVFFGPDFITVTKENEELDWNLLKPDIYATIMDFFASG
LPLVTEETPSGEAGSEEDDEVVAMIKELLDTRIRPTVQEDGGDVIYKGFEDGIVQLKLQGSCTSCPSSIITLKNGIQNMLQFYIPEVEGV

--------------------------------------------------------------
>63_63_3_AAK1-NFU1_AAK1_chr2_69870010_ENST00000409085_NFU1_chr2_69650849_ENST00000410022_length(transcript)=1635nt_BP=540nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
TGAGATACATGTTTATTCAAACACAAGATACCCCAAATCCAAACAGCTTAAAGTTTATACCAGGAAAACCAGTTCTTGAGACAAGGACCA
TGGATTTTCCCACCCCAGCTGCAGCATTTCGCTCCCCTCTGGCTAGGCAGTTATTTAGGATTGAAGGAGTAAAAAGTGTCTTCTTTGGAC
CAGATTTCATCACTGTCACAAAGGAAAATGAAGAATTAGACTGGAATTTACTGAAACCAGATATTTATGCAACAATCATGGACTTCTTTG
CATCTGGCTTACCCCTGGTTACTGAGGAAACACCTTCAGGAGAAGCAGGATCTGAAGAAGATGATGAAGTTGTGGCAATGATTAAGGAAT
TGTTAGATACTAGAATACGGCCAACTGTGCAGGAAGATGGAGGGGATGTAATCTACAAAGGCTTTGAAGATGGCATTGTACAGCTGAAAC
TCCAGGGTTCTTGTACCAGCTGCCCTAGTTCAATCATTACTCTGAAAAATGGAATTCAGAACATGCTGCAGTTTTATATTCCGGAGGTAG
AAGGCGTAGAACAGGTTATGGATGATGAATCAGATGAAAAAGAAGCAAACTCACCTTAAAATAATCTGGATTTTCTTTGGGCATAACAGT
CAGACTTGTTGATAATATATATCAAGTTTTTATTATTAATATGCTGAGGAACTTGAAGATTAATAAAATATGCTCTTCAGAGAATGATAT
ATAAATATTGCATGTTTGCTTTACCTCATATGAGTTATTTATAACCTCTTGAATCATCTTCTGTACACGTGGATTTTATCCAAGGATATT
TTTATTTTTGTCCCTCATTTCCCATGGCTCTTTCTTTGCATATGTGTGAAGGAGTTTAAAATACATTTCCCCCCATCTAATTTATTTACT
TTTTTCCATACAGGAAGAAACAGAATGCTTTTTAGAATATTCTAAAATAGCTTTTTGTGAAATATCTAAAACTATTTTTACTGAAGTTTT
TAGCTTAAGAAACAGCTAAACAAGTCTGTTTTAAAAATGGTATCTGGCTACTAGCCCCCAATTAAGTAGCAAAGAACTGCTTAAGACCAA

>63_63_3_AAK1-NFU1_AAK1_chr2_69870010_ENST00000409085_NFU1_chr2_69650849_ENST00000410022_length(amino acids)=286AA_BP=1
MRRNPWISFLKKKKKKKKSRNHRYFALLLPIRKMKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEVRY
MFIQTQDTPNPNSLKFIPGKPVLETRTMDFPTPAAAFRSPLARQLFRIEGVKSVFFGPDFITVTKENEELDWNLLKPDIYATIMDFFASG
LPLVTEETPSGEAGSEEDDEVVAMIKELLDTRIRPTVQEDGGDVIYKGFEDGIVQLKLQGSCTSCPSSIITLKNGIQNMLQFYIPEVEGV

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Fusion Gene PPI Analysis for AAK1-NFU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AAK1-NFU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AAK1-NFU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource