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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PBRM1-TKT (FusionGDB2 ID:63010)

Fusion Gene Summary for PBRM1-TKT

check button Fusion gene summary
Fusion gene informationFusion gene name: PBRM1-TKT
Fusion gene ID: 63010
HgeneTgene
Gene symbol

PBRM1

TKT

Gene ID

55193

7086

Gene namepolybromo 1transketolase
SynonymsBAF180|PB1HEL-S-48|HEL107|SDDHD|TK|TKT1
Cytomap

3p21.1

3p21.1

Type of geneprotein-codingprotein-coding
Descriptionprotein polybromo-1BRG1-associated factor 180polybromo-1Dtransketolaseepididymis luminal protein 107epididymis secretory protein Li 48
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000296302, ENST00000337303, 
ENST00000356770, ENST00000394830, 
ENST00000409057, ENST00000409114, 
ENST00000409767, ENST00000410007, 
ENST00000296289, ENST00000423516, 
ENST00000461139, ENST00000462138, 
ENST00000423525, 
Fusion gene scores* DoF score15 X 15 X 10=225018 X 16 X 9=2592
# samples 1925
** MAII scorelog2(19/2250*10)=-3.56585367777345
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/2592*10)=-3.37406571822254
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PBRM1 [Title/Abstract] AND TKT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPBRM1(52692215)-TKT(53276258), # samples:3
Anticipated loss of major functional domain due to fusion event.PBRM1-TKT seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PBRM1-TKT seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PBRM1-TKT seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PBRM1-TKT seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PBRM1-TKT seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PBRM1-TKT seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTKT

GO:0046166

glyceraldehyde-3-phosphate biosynthetic process

9611778


check buttonFusion gene breakpoints across PBRM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TKT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A26G-01APBRM1chr3

52692215

-TKTchr3

53276258

-
ChimerDB4BRCATCGA-A7-A26GPBRM1chr3

52692214

-TKTchr3

53276258

-


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Fusion Gene ORF analysis for PBRM1-TKT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000296302ENST00000296289PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-5UTRENST00000296302ENST00000296289PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-5UTRENST00000337303ENST00000296289PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-5UTRENST00000337303ENST00000296289PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-5UTRENST00000356770ENST00000296289PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-5UTRENST00000356770ENST00000296289PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-5UTRENST00000394830ENST00000296289PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-5UTRENST00000394830ENST00000296289PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-5UTRENST00000409057ENST00000296289PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-5UTRENST00000409057ENST00000296289PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-5UTRENST00000409114ENST00000296289PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-5UTRENST00000409114ENST00000296289PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-5UTRENST00000409767ENST00000296289PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-5UTRENST00000409767ENST00000296289PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-5UTRENST00000410007ENST00000296289PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-5UTRENST00000410007ENST00000296289PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000296302ENST00000423516PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000296302ENST00000423516PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000296302ENST00000461139PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000296302ENST00000461139PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000337303ENST00000423516PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000337303ENST00000423516PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000337303ENST00000461139PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000337303ENST00000461139PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000356770ENST00000423516PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000356770ENST00000423516PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000356770ENST00000461139PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000356770ENST00000461139PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000394830ENST00000423516PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000394830ENST00000423516PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000394830ENST00000461139PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000394830ENST00000461139PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000409057ENST00000423516PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000409057ENST00000423516PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000409057ENST00000461139PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000409057ENST00000461139PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000409114ENST00000423516PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000409114ENST00000423516PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000409114ENST00000461139PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000409114ENST00000461139PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000409767ENST00000423516PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000409767ENST00000423516PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000409767ENST00000461139PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000409767ENST00000461139PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000410007ENST00000423516PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000410007ENST00000423516PBRM1chr3

52692214

-TKTchr3

53276258

-
5CDS-intronENST00000410007ENST00000461139PBRM1chr3

52692215

-TKTchr3

53276258

-
5CDS-intronENST00000410007ENST00000461139PBRM1chr3

52692214

-TKTchr3

53276258

-
Frame-shiftENST00000296302ENST00000462138PBRM1chr3

52692215

-TKTchr3

53276258

-
Frame-shiftENST00000296302ENST00000462138PBRM1chr3

52692214

-TKTchr3

53276258

-
Frame-shiftENST00000337303ENST00000462138PBRM1chr3

52692215

-TKTchr3

53276258

-
Frame-shiftENST00000337303ENST00000462138PBRM1chr3

52692214

-TKTchr3

53276258

-
Frame-shiftENST00000356770ENST00000462138PBRM1chr3

52692215

-TKTchr3

53276258

-
Frame-shiftENST00000356770ENST00000462138PBRM1chr3

52692214

-TKTchr3

53276258

-
Frame-shiftENST00000394830ENST00000423525PBRM1chr3

52692215

-TKTchr3

53276258

-
Frame-shiftENST00000394830ENST00000423525PBRM1chr3

52692214

-TKTchr3

53276258

-
Frame-shiftENST00000409057ENST00000462138PBRM1chr3

52692215

-TKTchr3

53276258

-
Frame-shiftENST00000409057ENST00000462138PBRM1chr3

52692214

-TKTchr3

53276258

-
Frame-shiftENST00000409114ENST00000462138PBRM1chr3

52692215

-TKTchr3

53276258

-
Frame-shiftENST00000409114ENST00000462138PBRM1chr3

52692214

-TKTchr3

53276258

-
Frame-shiftENST00000409767ENST00000462138PBRM1chr3

52692215

-TKTchr3

53276258

-
Frame-shiftENST00000409767ENST00000462138PBRM1chr3

52692214

-TKTchr3

53276258

-
Frame-shiftENST00000410007ENST00000462138PBRM1chr3

52692215

-TKTchr3

53276258

-
Frame-shiftENST00000410007ENST00000462138PBRM1chr3

52692214

-TKTchr3

53276258

-
In-frameENST00000296302ENST00000423525PBRM1chr3

52692215

-TKTchr3

53276258

-
In-frameENST00000296302ENST00000423525PBRM1chr3

52692214

-TKTchr3

53276258

-
In-frameENST00000337303ENST00000423525PBRM1chr3

52692215

-TKTchr3

53276258

-
In-frameENST00000337303ENST00000423525PBRM1chr3

52692214

-TKTchr3

53276258

-
In-frameENST00000356770ENST00000423525PBRM1chr3

52692215

-TKTchr3

53276258

-
In-frameENST00000356770ENST00000423525PBRM1chr3

52692214

-TKTchr3

53276258

-
In-frameENST00000394830ENST00000462138PBRM1chr3

52692215

-TKTchr3

53276258

-
In-frameENST00000394830ENST00000462138PBRM1chr3

52692214

-TKTchr3

53276258

-
In-frameENST00000409057ENST00000423525PBRM1chr3

52692215

-TKTchr3

53276258

-
In-frameENST00000409057ENST00000423525PBRM1chr3

52692214

-TKTchr3

53276258

-
In-frameENST00000409114ENST00000423525PBRM1chr3

52692215

-TKTchr3

53276258

-
In-frameENST00000409114ENST00000423525PBRM1chr3

52692214

-TKTchr3

53276258

-
In-frameENST00000409767ENST00000423525PBRM1chr3

52692215

-TKTchr3

53276258

-
In-frameENST00000409767ENST00000423525PBRM1chr3

52692214

-TKTchr3

53276258

-
In-frameENST00000410007ENST00000423525PBRM1chr3

52692215

-TKTchr3

53276258

-
In-frameENST00000410007ENST00000423525PBRM1chr3

52692214

-TKTchr3

53276258

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356770PBRM1chr352692215-ENST00000423525TKTchr353276258-33146486822412576
ENST00000394830PBRM1chr352692215-ENST00000462138TKTchr353276258-35597457792509576
ENST00000296302PBRM1chr352692215-ENST00000423525TKTchr353276258-33136476812411576
ENST00000337303PBRM1chr352692215-ENST00000423525TKTchr353276258-33146486822412576
ENST00000410007PBRM1chr352692215-ENST00000423525TKTchr353276258-33146486822412576
ENST00000409057PBRM1chr352692215-ENST00000423525TKTchr353276258-33146486822412576
ENST00000409114PBRM1chr352692215-ENST00000423525TKTchr353276258-33146486822412576
ENST00000409767PBRM1chr352692215-ENST00000423525TKTchr353276258-33146486822412576
ENST00000356770PBRM1chr352692214-ENST00000423525TKTchr353276258-33146486822412576
ENST00000394830PBRM1chr352692214-ENST00000462138TKTchr353276258-35597457792509576
ENST00000296302PBRM1chr352692214-ENST00000423525TKTchr353276258-33136476812411576
ENST00000337303PBRM1chr352692214-ENST00000423525TKTchr353276258-33146486822412576
ENST00000410007PBRM1chr352692214-ENST00000423525TKTchr353276258-33146486822412576
ENST00000409057PBRM1chr352692214-ENST00000423525TKTchr353276258-33146486822412576
ENST00000409114PBRM1chr352692214-ENST00000423525TKTchr353276258-33146486822412576
ENST00000409767PBRM1chr352692214-ENST00000423525TKTchr353276258-33146486822412576

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356770ENST00000423525PBRM1chr352692215-TKTchr353276258-0.0076047680.9923953
ENST00000394830ENST00000462138PBRM1chr352692215-TKTchr353276258-0.0068170750.99318296
ENST00000296302ENST00000423525PBRM1chr352692215-TKTchr353276258-0.0076185170.9923815
ENST00000337303ENST00000423525PBRM1chr352692215-TKTchr353276258-0.0076047680.9923953
ENST00000410007ENST00000423525PBRM1chr352692215-TKTchr353276258-0.0076047680.9923953
ENST00000409057ENST00000423525PBRM1chr352692215-TKTchr353276258-0.0076047680.9923953
ENST00000409114ENST00000423525PBRM1chr352692215-TKTchr353276258-0.0076047680.9923953
ENST00000409767ENST00000423525PBRM1chr352692215-TKTchr353276258-0.0076047680.9923953
ENST00000356770ENST00000423525PBRM1chr352692214-TKTchr353276258-0.0076047680.9923953
ENST00000394830ENST00000462138PBRM1chr352692214-TKTchr353276258-0.0068170750.99318296
ENST00000296302ENST00000423525PBRM1chr352692214-TKTchr353276258-0.0076185170.9923815
ENST00000337303ENST00000423525PBRM1chr352692214-TKTchr353276258-0.0076047680.9923953
ENST00000410007ENST00000423525PBRM1chr352692214-TKTchr353276258-0.0076047680.9923953
ENST00000409057ENST00000423525PBRM1chr352692214-TKTchr353276258-0.0076047680.9923953
ENST00000409114ENST00000423525PBRM1chr352692214-TKTchr353276258-0.0076047680.9923953
ENST00000409767ENST00000423525PBRM1chr352692214-TKTchr353276258-0.0076047680.9923953

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Fusion Genomic Features for PBRM1-TKT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PBRM1-TKT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52692215/chr3:53276258)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBRM1chr3:52692214chr3:53276258ENST00000296302-53064_1342151690.0DomainBromo 1
HgenePBRM1chr3:52692214chr3:53276258ENST00000337303-52864_1342151583.0DomainBromo 1
HgenePBRM1chr3:52692214chr3:53276258ENST00000356770-52864_1342151603.0DomainBromo 1
HgenePBRM1chr3:52692214chr3:53276258ENST00000394830-63064_1342151583.0DomainBromo 1
HgenePBRM1chr3:52692214chr3:53276258ENST00000409057-52964_1342151635.0DomainBromo 1
HgenePBRM1chr3:52692214chr3:53276258ENST00000409114-53064_1342151653.0DomainBromo 1
HgenePBRM1chr3:52692214chr3:53276258ENST00000409767-52964_1342151598.0DomainBromo 1
HgenePBRM1chr3:52692214chr3:53276258ENST00000410007-52964_1342151610.0DomainBromo 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000296302-53064_1342151690.0DomainBromo 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000337303-52864_1342151583.0DomainBromo 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000356770-52864_1342151603.0DomainBromo 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000394830-63064_1342151583.0DomainBromo 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000409057-52964_1342151635.0DomainBromo 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000409114-53064_1342151653.0DomainBromo 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000409767-52964_1342151598.0DomainBromo 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000410007-52964_1342151610.0DomainBromo 1
TgeneTKTchr3:52692214chr3:53276258ENST00000423516015123_12535632.0Nucleotide bindingNote=Thiamine pyrophosphate
TgeneTKTchr3:52692214chr3:53276258ENST00000423525015123_12535888.6666666666666Nucleotide bindingNote=Thiamine pyrophosphate
TgeneTKTchr3:52692214chr3:53276258ENST00000462138014123_12535624.0Nucleotide bindingNote=Thiamine pyrophosphate
TgeneTKTchr3:52692215chr3:53276258ENST00000423516015123_12535632.0Nucleotide bindingNote=Thiamine pyrophosphate
TgeneTKTchr3:52692215chr3:53276258ENST00000423525015123_12535888.6666666666666Nucleotide bindingNote=Thiamine pyrophosphate
TgeneTKTchr3:52692215chr3:53276258ENST00000462138014123_12535624.0Nucleotide bindingNote=Thiamine pyrophosphate

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBRM1chr3:52692214chr3:53276258ENST00000296302-5301468_15992151690.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692214chr3:53276258ENST00000296302-530630_6332151690.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692214chr3:53276258ENST00000337303-5281468_15992151583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692214chr3:53276258ENST00000337303-528630_6332151583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692214chr3:53276258ENST00000356770-5281468_15992151603.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692214chr3:53276258ENST00000356770-528630_6332151603.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692214chr3:53276258ENST00000394830-6301468_15992151583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692214chr3:53276258ENST00000394830-630630_6332151583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692214chr3:53276258ENST00000409057-5291468_15992151635.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692214chr3:53276258ENST00000409057-529630_6332151635.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692214chr3:53276258ENST00000409114-5301468_15992151653.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692214chr3:53276258ENST00000409114-530630_6332151653.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692214chr3:53276258ENST00000409767-5291468_15992151598.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692214chr3:53276258ENST00000409767-529630_6332151598.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692214chr3:53276258ENST00000410007-5291468_15992151610.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692214chr3:53276258ENST00000410007-529630_6332151610.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692215chr3:53276258ENST00000296302-5301468_15992151690.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692215chr3:53276258ENST00000296302-530630_6332151690.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692215chr3:53276258ENST00000337303-5281468_15992151583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692215chr3:53276258ENST00000337303-528630_6332151583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692215chr3:53276258ENST00000356770-5281468_15992151603.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692215chr3:53276258ENST00000356770-528630_6332151603.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692215chr3:53276258ENST00000394830-6301468_15992151583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692215chr3:53276258ENST00000394830-630630_6332151583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692215chr3:53276258ENST00000409057-5291468_15992151635.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692215chr3:53276258ENST00000409057-529630_6332151635.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692215chr3:53276258ENST00000409114-5301468_15992151653.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692215chr3:53276258ENST00000409114-530630_6332151653.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692215chr3:53276258ENST00000409767-5291468_15992151598.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692215chr3:53276258ENST00000409767-529630_6332151598.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692215chr3:53276258ENST00000410007-5291468_15992151610.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52692215chr3:53276258ENST00000410007-529630_6332151610.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52692214chr3:53276258ENST00000296302-5301379_14472151690.0DNA bindingHMG box
HgenePBRM1chr3:52692214chr3:53276258ENST00000337303-5281379_14472151583.0DNA bindingHMG box
HgenePBRM1chr3:52692214chr3:53276258ENST00000356770-5281379_14472151603.0DNA bindingHMG box
HgenePBRM1chr3:52692214chr3:53276258ENST00000394830-6301379_14472151583.0DNA bindingHMG box
HgenePBRM1chr3:52692214chr3:53276258ENST00000409057-5291379_14472151635.0DNA bindingHMG box
HgenePBRM1chr3:52692214chr3:53276258ENST00000409114-5301379_14472151653.0DNA bindingHMG box
HgenePBRM1chr3:52692214chr3:53276258ENST00000409767-5291379_14472151598.0DNA bindingHMG box
HgenePBRM1chr3:52692214chr3:53276258ENST00000410007-5291379_14472151610.0DNA bindingHMG box
HgenePBRM1chr3:52692215chr3:53276258ENST00000296302-5301379_14472151690.0DNA bindingHMG box
HgenePBRM1chr3:52692215chr3:53276258ENST00000337303-5281379_14472151583.0DNA bindingHMG box
HgenePBRM1chr3:52692215chr3:53276258ENST00000356770-5281379_14472151603.0DNA bindingHMG box
HgenePBRM1chr3:52692215chr3:53276258ENST00000394830-6301379_14472151583.0DNA bindingHMG box
HgenePBRM1chr3:52692215chr3:53276258ENST00000409057-5291379_14472151635.0DNA bindingHMG box
HgenePBRM1chr3:52692215chr3:53276258ENST00000409114-5301379_14472151653.0DNA bindingHMG box
HgenePBRM1chr3:52692215chr3:53276258ENST00000409767-5291379_14472151598.0DNA bindingHMG box
HgenePBRM1chr3:52692215chr3:53276258ENST00000410007-5291379_14472151610.0DNA bindingHMG box
HgenePBRM1chr3:52692214chr3:53276258ENST00000296302-5301156_12722151690.0DomainBAH 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000296302-530200_2702151690.0DomainBromo 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000296302-530400_4702151690.0DomainBromo 3
HgenePBRM1chr3:52692214chr3:53276258ENST00000296302-530538_6082151690.0DomainBromo 4
HgenePBRM1chr3:52692214chr3:53276258ENST00000296302-530676_7462151690.0DomainBromo 5
HgenePBRM1chr3:52692214chr3:53276258ENST00000296302-530792_8622151690.0DomainBromo 6
HgenePBRM1chr3:52692214chr3:53276258ENST00000296302-530956_10742151690.0DomainBAH 1
HgenePBRM1chr3:52692214chr3:53276258ENST00000337303-5281156_12722151583.0DomainBAH 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000337303-528200_2702151583.0DomainBromo 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000337303-528400_4702151583.0DomainBromo 3
HgenePBRM1chr3:52692214chr3:53276258ENST00000337303-528538_6082151583.0DomainBromo 4
HgenePBRM1chr3:52692214chr3:53276258ENST00000337303-528676_7462151583.0DomainBromo 5
HgenePBRM1chr3:52692214chr3:53276258ENST00000337303-528792_8622151583.0DomainBromo 6
HgenePBRM1chr3:52692214chr3:53276258ENST00000337303-528956_10742151583.0DomainBAH 1
HgenePBRM1chr3:52692214chr3:53276258ENST00000356770-5281156_12722151603.0DomainBAH 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000356770-528200_2702151603.0DomainBromo 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000356770-528400_4702151603.0DomainBromo 3
HgenePBRM1chr3:52692214chr3:53276258ENST00000356770-528538_6082151603.0DomainBromo 4
HgenePBRM1chr3:52692214chr3:53276258ENST00000356770-528676_7462151603.0DomainBromo 5
HgenePBRM1chr3:52692214chr3:53276258ENST00000356770-528792_8622151603.0DomainBromo 6
HgenePBRM1chr3:52692214chr3:53276258ENST00000356770-528956_10742151603.0DomainBAH 1
HgenePBRM1chr3:52692214chr3:53276258ENST00000394830-6301156_12722151583.0DomainBAH 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000394830-630200_2702151583.0DomainBromo 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000394830-630400_4702151583.0DomainBromo 3
HgenePBRM1chr3:52692214chr3:53276258ENST00000394830-630538_6082151583.0DomainBromo 4
HgenePBRM1chr3:52692214chr3:53276258ENST00000394830-630676_7462151583.0DomainBromo 5
HgenePBRM1chr3:52692214chr3:53276258ENST00000394830-630792_8622151583.0DomainBromo 6
HgenePBRM1chr3:52692214chr3:53276258ENST00000394830-630956_10742151583.0DomainBAH 1
HgenePBRM1chr3:52692214chr3:53276258ENST00000409057-5291156_12722151635.0DomainBAH 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000409057-529200_2702151635.0DomainBromo 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000409057-529400_4702151635.0DomainBromo 3
HgenePBRM1chr3:52692214chr3:53276258ENST00000409057-529538_6082151635.0DomainBromo 4
HgenePBRM1chr3:52692214chr3:53276258ENST00000409057-529676_7462151635.0DomainBromo 5
HgenePBRM1chr3:52692214chr3:53276258ENST00000409057-529792_8622151635.0DomainBromo 6
HgenePBRM1chr3:52692214chr3:53276258ENST00000409057-529956_10742151635.0DomainBAH 1
HgenePBRM1chr3:52692214chr3:53276258ENST00000409114-5301156_12722151653.0DomainBAH 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000409114-530200_2702151653.0DomainBromo 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000409114-530400_4702151653.0DomainBromo 3
HgenePBRM1chr3:52692214chr3:53276258ENST00000409114-530538_6082151653.0DomainBromo 4
HgenePBRM1chr3:52692214chr3:53276258ENST00000409114-530676_7462151653.0DomainBromo 5
HgenePBRM1chr3:52692214chr3:53276258ENST00000409114-530792_8622151653.0DomainBromo 6
HgenePBRM1chr3:52692214chr3:53276258ENST00000409114-530956_10742151653.0DomainBAH 1
HgenePBRM1chr3:52692214chr3:53276258ENST00000409767-5291156_12722151598.0DomainBAH 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000409767-529200_2702151598.0DomainBromo 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000409767-529400_4702151598.0DomainBromo 3
HgenePBRM1chr3:52692214chr3:53276258ENST00000409767-529538_6082151598.0DomainBromo 4
HgenePBRM1chr3:52692214chr3:53276258ENST00000409767-529676_7462151598.0DomainBromo 5
HgenePBRM1chr3:52692214chr3:53276258ENST00000409767-529792_8622151598.0DomainBromo 6
HgenePBRM1chr3:52692214chr3:53276258ENST00000409767-529956_10742151598.0DomainBAH 1
HgenePBRM1chr3:52692214chr3:53276258ENST00000410007-5291156_12722151610.0DomainBAH 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000410007-529200_2702151610.0DomainBromo 2
HgenePBRM1chr3:52692214chr3:53276258ENST00000410007-529400_4702151610.0DomainBromo 3
HgenePBRM1chr3:52692214chr3:53276258ENST00000410007-529538_6082151610.0DomainBromo 4
HgenePBRM1chr3:52692214chr3:53276258ENST00000410007-529676_7462151610.0DomainBromo 5
HgenePBRM1chr3:52692214chr3:53276258ENST00000410007-529792_8622151610.0DomainBromo 6
HgenePBRM1chr3:52692214chr3:53276258ENST00000410007-529956_10742151610.0DomainBAH 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000296302-5301156_12722151690.0DomainBAH 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000296302-530200_2702151690.0DomainBromo 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000296302-530400_4702151690.0DomainBromo 3
HgenePBRM1chr3:52692215chr3:53276258ENST00000296302-530538_6082151690.0DomainBromo 4
HgenePBRM1chr3:52692215chr3:53276258ENST00000296302-530676_7462151690.0DomainBromo 5
HgenePBRM1chr3:52692215chr3:53276258ENST00000296302-530792_8622151690.0DomainBromo 6
HgenePBRM1chr3:52692215chr3:53276258ENST00000296302-530956_10742151690.0DomainBAH 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000337303-5281156_12722151583.0DomainBAH 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000337303-528200_2702151583.0DomainBromo 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000337303-528400_4702151583.0DomainBromo 3
HgenePBRM1chr3:52692215chr3:53276258ENST00000337303-528538_6082151583.0DomainBromo 4
HgenePBRM1chr3:52692215chr3:53276258ENST00000337303-528676_7462151583.0DomainBromo 5
HgenePBRM1chr3:52692215chr3:53276258ENST00000337303-528792_8622151583.0DomainBromo 6
HgenePBRM1chr3:52692215chr3:53276258ENST00000337303-528956_10742151583.0DomainBAH 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000356770-5281156_12722151603.0DomainBAH 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000356770-528200_2702151603.0DomainBromo 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000356770-528400_4702151603.0DomainBromo 3
HgenePBRM1chr3:52692215chr3:53276258ENST00000356770-528538_6082151603.0DomainBromo 4
HgenePBRM1chr3:52692215chr3:53276258ENST00000356770-528676_7462151603.0DomainBromo 5
HgenePBRM1chr3:52692215chr3:53276258ENST00000356770-528792_8622151603.0DomainBromo 6
HgenePBRM1chr3:52692215chr3:53276258ENST00000356770-528956_10742151603.0DomainBAH 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000394830-6301156_12722151583.0DomainBAH 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000394830-630200_2702151583.0DomainBromo 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000394830-630400_4702151583.0DomainBromo 3
HgenePBRM1chr3:52692215chr3:53276258ENST00000394830-630538_6082151583.0DomainBromo 4
HgenePBRM1chr3:52692215chr3:53276258ENST00000394830-630676_7462151583.0DomainBromo 5
HgenePBRM1chr3:52692215chr3:53276258ENST00000394830-630792_8622151583.0DomainBromo 6
HgenePBRM1chr3:52692215chr3:53276258ENST00000394830-630956_10742151583.0DomainBAH 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000409057-5291156_12722151635.0DomainBAH 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000409057-529200_2702151635.0DomainBromo 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000409057-529400_4702151635.0DomainBromo 3
HgenePBRM1chr3:52692215chr3:53276258ENST00000409057-529538_6082151635.0DomainBromo 4
HgenePBRM1chr3:52692215chr3:53276258ENST00000409057-529676_7462151635.0DomainBromo 5
HgenePBRM1chr3:52692215chr3:53276258ENST00000409057-529792_8622151635.0DomainBromo 6
HgenePBRM1chr3:52692215chr3:53276258ENST00000409057-529956_10742151635.0DomainBAH 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000409114-5301156_12722151653.0DomainBAH 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000409114-530200_2702151653.0DomainBromo 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000409114-530400_4702151653.0DomainBromo 3
HgenePBRM1chr3:52692215chr3:53276258ENST00000409114-530538_6082151653.0DomainBromo 4
HgenePBRM1chr3:52692215chr3:53276258ENST00000409114-530676_7462151653.0DomainBromo 5
HgenePBRM1chr3:52692215chr3:53276258ENST00000409114-530792_8622151653.0DomainBromo 6
HgenePBRM1chr3:52692215chr3:53276258ENST00000409114-530956_10742151653.0DomainBAH 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000409767-5291156_12722151598.0DomainBAH 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000409767-529200_2702151598.0DomainBromo 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000409767-529400_4702151598.0DomainBromo 3
HgenePBRM1chr3:52692215chr3:53276258ENST00000409767-529538_6082151598.0DomainBromo 4
HgenePBRM1chr3:52692215chr3:53276258ENST00000409767-529676_7462151598.0DomainBromo 5
HgenePBRM1chr3:52692215chr3:53276258ENST00000409767-529792_8622151598.0DomainBromo 6
HgenePBRM1chr3:52692215chr3:53276258ENST00000409767-529956_10742151598.0DomainBAH 1
HgenePBRM1chr3:52692215chr3:53276258ENST00000410007-5291156_12722151610.0DomainBAH 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000410007-529200_2702151610.0DomainBromo 2
HgenePBRM1chr3:52692215chr3:53276258ENST00000410007-529400_4702151610.0DomainBromo 3
HgenePBRM1chr3:52692215chr3:53276258ENST00000410007-529538_6082151610.0DomainBromo 4
HgenePBRM1chr3:52692215chr3:53276258ENST00000410007-529676_7462151610.0DomainBromo 5
HgenePBRM1chr3:52692215chr3:53276258ENST00000410007-529792_8622151610.0DomainBromo 6
HgenePBRM1chr3:52692215chr3:53276258ENST00000410007-529956_10742151610.0DomainBAH 1


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Fusion Gene Sequence for PBRM1-TKT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63010_63010_1_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000296302_TKT_chr3_53276258_ENST00000423525_length(transcript)=3313nt_BP=647nt
CCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCAG
GCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGACT
ATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCTC
AGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTTT
TTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAATG
AGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCAG
CTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACTTTTTCAGA
AACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTCC
CAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGGT
TTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGTG
GCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTAT
TGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGCC
ATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGGT
TGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGCC
AAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGATC
ATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAAC
ATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCAT
GCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCATC
GAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGCA
GCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTCC
ATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGAT
GGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCATC
TATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGTG
ACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCTG
GACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGAG
GCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGAG
CTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGCCAGTGCAGGTTC
TGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCACC
TGCAACTGCCCTCAACCTCCAGAACTATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGCT
GAGACCTACATCCCTCATTGTGACCTCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCTC
AGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCTT
GTCATATCCTTTTAACTAGGCATCTCAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGAG
GTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTGA
CAACTGGCCCAGGAGCTTCTGATGTCACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCCC
TCACACTGCTGACCACAGTGGATTTCTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCTT
ATACTGGCCAAGAACAAACTAGTGCTGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTGC

>63010_63010_1_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000296302_TKT_chr3_53276258_ENST00000423525_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_2_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000337303_TKT_chr3_53276258_ENST00000423525_length(transcript)=3314nt_BP=648nt
TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCA
GGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGAC
TATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCT
CAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTT
TTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAAT
GAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCA
GCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACTTTTTCAG
AAACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTC
CCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGG
TTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGT
GGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTA
TTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGC
CATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGG
TTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGC
CAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGAT
CATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAA
CATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCA
TGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCAT
CGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGC
AGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTC
CATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGA
TGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCAT
CTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGT
GACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCT
GGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGA
GGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGA
GCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGCCAGTGCAGGTT
CTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCAC
CTGCAACTGCCCTCAACCTCCAGAACTATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGC
TGAGACCTACATCCCTCATTGTGACCTCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCT
CAGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCT
TGTCATATCCTTTTAACTAGGCATCTCAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGA
GGTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTG
ACAACTGGCCCAGGAGCTTCTGATGTCACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCC
CTCACACTGCTGACCACAGTGGATTTCTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCT
TATACTGGCCAAGAACAAACTAGTGCTGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTG

>63010_63010_2_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000337303_TKT_chr3_53276258_ENST00000423525_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_3_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000356770_TKT_chr3_53276258_ENST00000423525_length(transcript)=3314nt_BP=648nt
TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCA
GGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGAC
TATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCT
CAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTT
TTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAAT
GAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCA
GCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACTTTTTCAG
AAACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTC
CCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGG
TTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGT
GGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTA
TTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGC
CATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGG
TTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGC
CAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGAT
CATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAA
CATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCA
TGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCAT
CGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGC
AGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTC
CATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGA
TGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCAT
CTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGT
GACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCT
GGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGA
GGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGA
GCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGCCAGTGCAGGTT
CTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCAC
CTGCAACTGCCCTCAACCTCCAGAACTATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGC
TGAGACCTACATCCCTCATTGTGACCTCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCT
CAGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCT
TGTCATATCCTTTTAACTAGGCATCTCAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGA
GGTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTG
ACAACTGGCCCAGGAGCTTCTGATGTCACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCC
CTCACACTGCTGACCACAGTGGATTTCTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCT
TATACTGGCCAAGAACAAACTAGTGCTGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTG

>63010_63010_3_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000356770_TKT_chr3_53276258_ENST00000423525_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_4_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000394830_TKT_chr3_53276258_ENST00000462138_length(transcript)=3559nt_BP=745nt
AGGAGCAATAGCAGCAGCCGTGGCGGCCACGGGGCGGGGCGCGGCGGTCGGTGACCGCGGCCGGGGCTGCAGGCGGCGGAGCGGCTGGAA
GTTGGATTCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTC
AACACCAGGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCAT
CCGAGACTATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGT
GGTTTCTCAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCA
GCTTCTTTTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAAC
AAGAAATGAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATC
TTCTCCAGCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACT
TTTTCAGAAACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCT
ACAAGTCCCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTG
AAGCTGGTTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCA
CCGACGTGGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACC
GAGTCTATTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACC
TTGTGGCCATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGG
CCTTCGGTTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCA
TCATTGCCAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTG
AGCAGATCATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACA
TTGCCAACATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGC
TGGGCCATGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACC
GCTTCATCGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCA
CTTTTGCAGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCG
GCGTTTCCATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACC
CAAGTGATGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATG
CCATCATCTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGG
CTGGGGTGACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCA
AGCCCCTGGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCA
TTGGTGAGGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGC
CGGCTGAGCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGGTATG
AAGTGTGGGGCGGGGGTCTATACATTCCTGAGATTCTGGGAAAGGTGCTCAAAGATGTACTGAGAGGAGGGGTAAATATATGTTTTGAGA
AAAATGAATTGGCCCTGAAATGTTTTCTTTTTTGATGTGTTTGCAGCCAGTGCAGGTTCTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGA
GGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCACCTGCAACTGCCCTCAACCTCCAGAACTATCGC
TGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGCTGAGACCTACATCCCTCATTGTGACCTCAGTC
CACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCTCAGGGCCGCCCCACCTCCCCCAAGTCCCCACA
GCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCTTGTCATATCCTTTTAACTAGGCATCTCAGAGA
AGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGAGGTCCTCAATCCCAAGTGTGGAACTGTCCCCC
TCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTGACAACTGGCCCAGGAGCTTCTGATGTCACACA
GAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCCCTCACACTGCTGACCACAGTGGATTTCTCCCC
CTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCTTATACTGGCCAAGAACAAACTAGTGCTGGGGG
AGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTGCGAGGATGAGACACATTTGTGGACACGTCCAC

>63010_63010_4_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000394830_TKT_chr3_53276258_ENST00000462138_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_5_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000409057_TKT_chr3_53276258_ENST00000423525_length(transcript)=3314nt_BP=648nt
TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCA
GGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGAC
TATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCT
CAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTT
TTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAAT
GAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCA
GCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACTTTTTCAG
AAACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTC
CCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGG
TTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGT
GGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTA
TTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGC
CATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGG
TTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGC
CAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGAT
CATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAA
CATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCA
TGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCAT
CGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGC
AGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTC
CATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGA
TGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCAT
CTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGT
GACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCT
GGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGA
GGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGA
GCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGCCAGTGCAGGTT
CTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCAC
CTGCAACTGCCCTCAACCTCCAGAACTATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGC
TGAGACCTACATCCCTCATTGTGACCTCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCT
CAGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCT
TGTCATATCCTTTTAACTAGGCATCTCAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGA
GGTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTG
ACAACTGGCCCAGGAGCTTCTGATGTCACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCC
CTCACACTGCTGACCACAGTGGATTTCTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCT
TATACTGGCCAAGAACAAACTAGTGCTGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTG

>63010_63010_5_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000409057_TKT_chr3_53276258_ENST00000423525_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_6_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000409114_TKT_chr3_53276258_ENST00000423525_length(transcript)=3314nt_BP=648nt
TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCA
GGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGAC
TATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCT
CAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTT
TTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAAT
GAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCA
GCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACTTTTTCAG
AAACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTC
CCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGG
TTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGT
GGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTA
TTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGC
CATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGG
TTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGC
CAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGAT
CATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAA
CATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCA
TGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCAT
CGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGC
AGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTC
CATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGA
TGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCAT
CTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGT
GACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCT
GGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGA
GGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGA
GCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGCCAGTGCAGGTT
CTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCAC
CTGCAACTGCCCTCAACCTCCAGAACTATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGC
TGAGACCTACATCCCTCATTGTGACCTCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCT
CAGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCT
TGTCATATCCTTTTAACTAGGCATCTCAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGA
GGTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTG
ACAACTGGCCCAGGAGCTTCTGATGTCACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCC
CTCACACTGCTGACCACAGTGGATTTCTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCT
TATACTGGCCAAGAACAAACTAGTGCTGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTG

>63010_63010_6_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000409114_TKT_chr3_53276258_ENST00000423525_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_7_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000409767_TKT_chr3_53276258_ENST00000423525_length(transcript)=3314nt_BP=648nt
TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCA
GGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGAC
TATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCT
CAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTT
TTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAAT
GAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCA
GCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACTTTTTCAG
AAACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTC
CCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGG
TTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGT
GGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTA
TTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGC
CATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGG
TTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGC
CAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGAT
CATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAA
CATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCA
TGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCAT
CGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGC
AGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTC
CATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGA
TGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCAT
CTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGT
GACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCT
GGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGA
GGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGA
GCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGCCAGTGCAGGTT
CTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCAC
CTGCAACTGCCCTCAACCTCCAGAACTATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGC
TGAGACCTACATCCCTCATTGTGACCTCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCT
CAGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCT
TGTCATATCCTTTTAACTAGGCATCTCAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGA
GGTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTG
ACAACTGGCCCAGGAGCTTCTGATGTCACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCC
CTCACACTGCTGACCACAGTGGATTTCTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCT
TATACTGGCCAAGAACAAACTAGTGCTGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTG

>63010_63010_7_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000409767_TKT_chr3_53276258_ENST00000423525_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_8_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000410007_TKT_chr3_53276258_ENST00000423525_length(transcript)=3314nt_BP=648nt
TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCA
GGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGAC
TATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCT
CAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTT
TTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAAT
GAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCA
GCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACTTTTTCAG
AAACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTC
CCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGG
TTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGT
GGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTA
TTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGC
CATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGG
TTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGC
CAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGAT
CATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAA
CATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCA
TGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCAT
CGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGC
AGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTC
CATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGA
TGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCAT
CTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGT
GACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCT
GGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGA
GGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGA
GCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGCCAGTGCAGGTT
CTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCAC
CTGCAACTGCCCTCAACCTCCAGAACTATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGC
TGAGACCTACATCCCTCATTGTGACCTCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCT
CAGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCT
TGTCATATCCTTTTAACTAGGCATCTCAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGA
GGTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTG
ACAACTGGCCCAGGAGCTTCTGATGTCACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCC
CTCACACTGCTGACCACAGTGGATTTCTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCT
TATACTGGCCAAGAACAAACTAGTGCTGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTG

>63010_63010_8_PBRM1-TKT_PBRM1_chr3_52692214_ENST00000410007_TKT_chr3_53276258_ENST00000423525_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_9_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000296302_TKT_chr3_53276258_ENST00000423525_length(transcript)=3313nt_BP=647nt
CCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCAG
GCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGACT
ATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCTC
AGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTTT
TTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAATG
AGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCAG
CTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACTTTTTCAGA
AACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTCC
CAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGGT
TTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGTG
GCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTAT
TGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGCC
ATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGGT
TGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGCC
AAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGATC
ATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAAC
ATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCAT
GCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCATC
GAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGCA
GCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTCC
ATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGAT
GGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCATC
TATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGTG
ACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCTG
GACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGAG
GCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGAG
CTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGCCAGTGCAGGTTC
TGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCACC
TGCAACTGCCCTCAACCTCCAGAACTATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGCT
GAGACCTACATCCCTCATTGTGACCTCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCTC
AGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCTT
GTCATATCCTTTTAACTAGGCATCTCAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGAG
GTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTGA
CAACTGGCCCAGGAGCTTCTGATGTCACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCCC
TCACACTGCTGACCACAGTGGATTTCTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCTT
ATACTGGCCAAGAACAAACTAGTGCTGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTGC

>63010_63010_9_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000296302_TKT_chr3_53276258_ENST00000423525_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_10_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000337303_TKT_chr3_53276258_ENST00000423525_length(transcript)=3314nt_BP=648nt
TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCA
GGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGAC
TATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCT
CAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTT
TTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAAT
GAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCA
GCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACTTTTTCAG
AAACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTC
CCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGG
TTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGT
GGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTA
TTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGC
CATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGG
TTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGC
CAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGAT
CATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAA
CATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCA
TGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCAT
CGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGC
AGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTC
CATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGA
TGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCAT
CTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGT
GACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCT
GGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGA
GGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGA
GCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGCCAGTGCAGGTT
CTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCAC
CTGCAACTGCCCTCAACCTCCAGAACTATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGC
TGAGACCTACATCCCTCATTGTGACCTCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCT
CAGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCT
TGTCATATCCTTTTAACTAGGCATCTCAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGA
GGTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTG
ACAACTGGCCCAGGAGCTTCTGATGTCACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCC
CTCACACTGCTGACCACAGTGGATTTCTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCT
TATACTGGCCAAGAACAAACTAGTGCTGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTG

>63010_63010_10_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000337303_TKT_chr3_53276258_ENST00000423525_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_11_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000356770_TKT_chr3_53276258_ENST00000423525_length(transcript)=3314nt_BP=648nt
TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCA
GGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGAC
TATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCT
CAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTT
TTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAAT
GAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCA
GCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACTTTTTCAG
AAACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTC
CCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGG
TTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGT
GGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTA
TTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGC
CATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGG
TTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGC
CAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGAT
CATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAA
CATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCA
TGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCAT
CGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGC
AGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTC
CATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGA
TGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCAT
CTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGT
GACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCT
GGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGA
GGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGA
GCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGCCAGTGCAGGTT
CTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCAC
CTGCAACTGCCCTCAACCTCCAGAACTATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGC
TGAGACCTACATCCCTCATTGTGACCTCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCT
CAGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCT
TGTCATATCCTTTTAACTAGGCATCTCAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGA
GGTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTG
ACAACTGGCCCAGGAGCTTCTGATGTCACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCC
CTCACACTGCTGACCACAGTGGATTTCTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCT
TATACTGGCCAAGAACAAACTAGTGCTGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTG

>63010_63010_11_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000356770_TKT_chr3_53276258_ENST00000423525_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_12_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000394830_TKT_chr3_53276258_ENST00000462138_length(transcript)=3559nt_BP=745nt
AGGAGCAATAGCAGCAGCCGTGGCGGCCACGGGGCGGGGCGCGGCGGTCGGTGACCGCGGCCGGGGCTGCAGGCGGCGGAGCGGCTGGAA
GTTGGATTCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTC
AACACCAGGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCAT
CCGAGACTATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGT
GGTTTCTCAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCA
GCTTCTTTTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAAC
AAGAAATGAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATC
TTCTCCAGCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACT
TTTTCAGAAACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCT
ACAAGTCCCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTG
AAGCTGGTTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCA
CCGACGTGGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACC
GAGTCTATTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACC
TTGTGGCCATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGG
CCTTCGGTTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCA
TCATTGCCAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTG
AGCAGATCATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACA
TTGCCAACATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGC
TGGGCCATGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACC
GCTTCATCGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCA
CTTTTGCAGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCG
GCGTTTCCATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACC
CAAGTGATGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATG
CCATCATCTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGG
CTGGGGTGACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCA
AGCCCCTGGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCA
TTGGTGAGGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGC
CGGCTGAGCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGGTATG
AAGTGTGGGGCGGGGGTCTATACATTCCTGAGATTCTGGGAAAGGTGCTCAAAGATGTACTGAGAGGAGGGGTAAATATATGTTTTGAGA
AAAATGAATTGGCCCTGAAATGTTTTCTTTTTTGATGTGTTTGCAGCCAGTGCAGGTTCTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGA
GGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCACCTGCAACTGCCCTCAACCTCCAGAACTATCGC
TGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGCTGAGACCTACATCCCTCATTGTGACCTCAGTC
CACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCTCAGGGCCGCCCCACCTCCCCCAAGTCCCCACA
GCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCTTGTCATATCCTTTTAACTAGGCATCTCAGAGA
AGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGAGGTCCTCAATCCCAAGTGTGGAACTGTCCCCC
TCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTGACAACTGGCCCAGGAGCTTCTGATGTCACACA
GAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCCCTCACACTGCTGACCACAGTGGATTTCTCCCC
CTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCTTATACTGGCCAAGAACAAACTAGTGCTGGGGG
AGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTGCGAGGATGAGACACATTTGTGGACACGTCCAC

>63010_63010_12_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000394830_TKT_chr3_53276258_ENST00000462138_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_13_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000409057_TKT_chr3_53276258_ENST00000423525_length(transcript)=3314nt_BP=648nt
TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCA
GGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGAC
TATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCT
CAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTT
TTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAAT
GAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCA
GCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACTTTTTCAG
AAACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTC
CCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGG
TTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGT
GGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTA
TTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGC
CATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGG
TTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGC
CAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGAT
CATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAA
CATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCA
TGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCAT
CGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGC
AGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTC
CATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGA
TGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCAT
CTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGT
GACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCT
GGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGA
GGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGA
GCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGCCAGTGCAGGTT
CTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCAC
CTGCAACTGCCCTCAACCTCCAGAACTATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGC
TGAGACCTACATCCCTCATTGTGACCTCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCT
CAGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCT
TGTCATATCCTTTTAACTAGGCATCTCAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGA
GGTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTG
ACAACTGGCCCAGGAGCTTCTGATGTCACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCC
CTCACACTGCTGACCACAGTGGATTTCTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCT
TATACTGGCCAAGAACAAACTAGTGCTGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTG

>63010_63010_13_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000409057_TKT_chr3_53276258_ENST00000423525_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_14_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000409114_TKT_chr3_53276258_ENST00000423525_length(transcript)=3314nt_BP=648nt
TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCA
GGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGAC
TATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCT
CAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTT
TTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAAT
GAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCA
GCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACTTTTTCAG
AAACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTC
CCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGG
TTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGT
GGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTA
TTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGC
CATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGG
TTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGC
CAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGAT
CATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAA
CATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCA
TGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCAT
CGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGC
AGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTC
CATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGA
TGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCAT
CTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGT
GACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCT
GGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGA
GGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGA
GCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGCCAGTGCAGGTT
CTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCAC
CTGCAACTGCCCTCAACCTCCAGAACTATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGC
TGAGACCTACATCCCTCATTGTGACCTCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCT
CAGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCT
TGTCATATCCTTTTAACTAGGCATCTCAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGA
GGTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTG
ACAACTGGCCCAGGAGCTTCTGATGTCACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCC
CTCACACTGCTGACCACAGTGGATTTCTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCT
TATACTGGCCAAGAACAAACTAGTGCTGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTG

>63010_63010_14_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000409114_TKT_chr3_53276258_ENST00000423525_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_15_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000409767_TKT_chr3_53276258_ENST00000423525_length(transcript)=3314nt_BP=648nt
TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCA
GGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGAC
TATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCT
CAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTT
TTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAAT
GAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCA
GCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACTTTTTCAG
AAACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTC
CCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGG
TTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGT
GGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTA
TTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGC
CATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGG
TTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGC
CAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGAT
CATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAA
CATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCA
TGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCAT
CGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGC
AGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTC
CATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGA
TGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCAT
CTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGT
GACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCT
GGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGA
GGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGA
GCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGCCAGTGCAGGTT
CTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCAC
CTGCAACTGCCCTCAACCTCCAGAACTATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGC
TGAGACCTACATCCCTCATTGTGACCTCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCT
CAGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCT
TGTCATATCCTTTTAACTAGGCATCTCAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGA
GGTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTG
ACAACTGGCCCAGGAGCTTCTGATGTCACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCC
CTCACACTGCTGACCACAGTGGATTTCTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCT
TATACTGGCCAAGAACAAACTAGTGCTGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTG

>63010_63010_15_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000409767_TKT_chr3_53276258_ENST00000423525_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------
>63010_63010_16_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000410007_TKT_chr3_53276258_ENST00000423525_length(transcript)=3314nt_BP=648nt
TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCA
GGCCCAAGCAGGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGAC
TATAAGGATGAACAGGGCAGACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCT
CAGCCCATTGACTTGATGAAAATCCAACAGAAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTT
TTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAAT
GAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCA
GCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCAGGACGTCTCATTAGCGAACTTTTTCAG
AAACTGCCTTCTAAAGTGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTC
CCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGG
TTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGT
GGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTA
TTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGC
CATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGG
TTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGC
CAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGAT
CATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAA
CATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCA
TGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCAT
CGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGC
AGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTC
CATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGA
TGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCAT
CTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGT
GACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCT
GGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGA
GGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGA
GCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGCCAGTGCAGGTT
CTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCAC
CTGCAACTGCCCTCAACCTCCAGAACTATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGC
TGAGACCTACATCCCTCATTGTGACCTCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCT
CAGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCT
TGTCATATCCTTTTAACTAGGCATCTCAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGA
GGTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTG
ACAACTGGCCCAGGAGCTTCTGATGTCACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCC
CTCACACTGCTGACCACAGTGGATTTCTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCT
TATACTGGCCAAGAACAAACTAGTGCTGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTG

>63010_63010_16_PBRM1-TKT_PBRM1_chr3_52692215_ENST00000410007_TKT_chr3_53276258_ENST00000423525_length(amino acids)=576AA_BP=
MAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAY
TGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKA
FGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIAT
RKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISE
SNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLK
SKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PBRM1-TKT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PBRM1-TKT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PBRM1-TKT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource