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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGEF38-PPA2 (FusionGDB2 ID:6303)

Fusion Gene Summary for ARHGEF38-PPA2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF38-PPA2
Fusion gene ID: 6303
HgeneTgene
Gene symbol

ARHGEF38

PPA2

Gene ID

54848

27068

Gene nameRho guanine nucleotide exchange factor 38inorganic pyrophosphatase 2
Synonyms-HSPC124|SCFAI|SCFI|SID6-306
Cytomap

4q24

4q24

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 38Rho guanine nucleotide exchange factor (GEF) 38inorganic pyrophosphatase 2, mitochondrialPPase 2pyrophosphatase (inorganic) 2pyrophosphatase SID6-306pyrophosphate phospho-hydrolase 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265154, ENST00000420470, 
ENST00000508036, 		ENST00000509426, 
ENST00000310267, ENST00000341695, 
ENST00000348706, ENST00000354147, 
ENST00000357415, ENST00000380004, 
ENST00000432483, 
Fusion gene scores* DoF score6 X 5 X 3=9017 X 10 X 8=1360
# samples 618
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1360*10)=-2.91753783980803
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGEF38 [Title/Abstract] AND PPA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF38(106474118)-PPA2(106320321), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGEF38 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A0JM-01AARHGEF38chr4

106474118

+PPA2chr4

106320321

-
ChimerDB4COADTCGA-CM-5868-01AARHGEF38chr4

106474118

+PPA2chr4

106320321

-
ChimerDB4READTCGA-DC-6154ARHGEF38chr4

106474118

+PPA2chr4

106320321

-


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Fusion Gene ORF analysis for ARHGEF38-PPA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265154ENST00000509426ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
5CDS-5UTRENST00000420470ENST00000509426ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
5CDS-intronENST00000265154ENST00000310267ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
5CDS-intronENST00000420470ENST00000310267ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
In-frameENST00000265154ENST00000341695ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
In-frameENST00000265154ENST00000348706ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
In-frameENST00000265154ENST00000354147ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
In-frameENST00000265154ENST00000357415ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
In-frameENST00000265154ENST00000380004ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
In-frameENST00000265154ENST00000432483ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
In-frameENST00000420470ENST00000341695ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
In-frameENST00000420470ENST00000348706ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
In-frameENST00000420470ENST00000354147ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
In-frameENST00000420470ENST00000357415ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
In-frameENST00000420470ENST00000380004ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
In-frameENST00000420470ENST00000432483ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
intron-3CDSENST00000508036ENST00000341695ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
intron-3CDSENST00000508036ENST00000348706ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
intron-3CDSENST00000508036ENST00000354147ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
intron-3CDSENST00000508036ENST00000357415ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
intron-3CDSENST00000508036ENST00000380004ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
intron-3CDSENST00000508036ENST00000432483ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
intron-5UTRENST00000508036ENST00000509426ARHGEF38chr4

106474118

+PPA2chr4

106320321

-
intron-intronENST00000508036ENST00000310267ARHGEF38chr4

106474118

+PPA2chr4

106320321

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000420470ARHGEF38chr4106474118+ENST00000341695PPA2chr4106320321-133834084689201
ENST00000420470ARHGEF38chr4106474118+ENST00000348706PPA2chr4106320321-117234084689201
ENST00000420470ARHGEF38chr4106474118+ENST00000432483PPA2chr4106320321-85034084689201
ENST00000420470ARHGEF38chr4106474118+ENST00000354147PPA2chr4106320321-85034084689201
ENST00000420470ARHGEF38chr4106474118+ENST00000380004PPA2chr4106320321-84734084689201
ENST00000420470ARHGEF38chr4106474118+ENST00000357415PPA2chr4106320321-84734084689201
ENST00000265154ARHGEF38chr4106474118+ENST00000341695PPA2chr4106320321-134034286691201
ENST00000265154ARHGEF38chr4106474118+ENST00000348706PPA2chr4106320321-117434286691201
ENST00000265154ARHGEF38chr4106474118+ENST00000432483PPA2chr4106320321-85234286691201
ENST00000265154ARHGEF38chr4106474118+ENST00000354147PPA2chr4106320321-85234286691201
ENST00000265154ARHGEF38chr4106474118+ENST00000380004PPA2chr4106320321-84934286691201
ENST00000265154ARHGEF38chr4106474118+ENST00000357415PPA2chr4106320321-84934286691201

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000420470ENST00000341695ARHGEF38chr4106474118+PPA2chr4106320321-0.0074444570.99255556
ENST00000420470ENST00000348706ARHGEF38chr4106474118+PPA2chr4106320321-0.0086826690.9913174
ENST00000420470ENST00000432483ARHGEF38chr4106474118+PPA2chr4106320321-0.0065685790.9934314
ENST00000420470ENST00000354147ARHGEF38chr4106474118+PPA2chr4106320321-0.0065685790.9934314
ENST00000420470ENST00000380004ARHGEF38chr4106474118+PPA2chr4106320321-0.0066462040.99335384
ENST00000420470ENST00000357415ARHGEF38chr4106474118+PPA2chr4106320321-0.0066462040.99335384
ENST00000265154ENST00000341695ARHGEF38chr4106474118+PPA2chr4106320321-0.0073259790.99267405
ENST00000265154ENST00000348706ARHGEF38chr4106474118+PPA2chr4106320321-0.0083437530.9916563
ENST00000265154ENST00000432483ARHGEF38chr4106474118+PPA2chr4106320321-0.006111440.9938885
ENST00000265154ENST00000354147ARHGEF38chr4106474118+PPA2chr4106320321-0.006111440.9938885
ENST00000265154ENST00000380004ARHGEF38chr4106474118+PPA2chr4106320321-0.0062103120.99378973
ENST00000265154ENST00000357415ARHGEF38chr4106474118+PPA2chr4106320321-0.0062103120.99378973

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Fusion Genomic Features for ARHGEF38-PPA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGEF38-PPA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:106474118/chr4:106320321)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF38chr4:106474118chr4:106320321ENST00000265154+14689_69465220.0Compositional biasNote=Poly-Ser
HgeneARHGEF38chr4:106474118chr4:106320321ENST00000420470+114689_69465778.0Compositional biasNote=Poly-Ser
HgeneARHGEF38chr4:106474118chr4:106320321ENST00000265154+14327_53665220.0DomainBAR
HgeneARHGEF38chr4:106474118chr4:106320321ENST00000265154+14582_64565220.0DomainSH3 1
HgeneARHGEF38chr4:106474118chr4:106320321ENST00000265154+14713_77665220.0DomainSH3 2
HgeneARHGEF38chr4:106474118chr4:106320321ENST00000265154+1494_28565220.0DomainDH
HgeneARHGEF38chr4:106474118chr4:106320321ENST00000420470+114327_53665778.0DomainBAR
HgeneARHGEF38chr4:106474118chr4:106320321ENST00000420470+114582_64565778.0DomainSH3 1
HgeneARHGEF38chr4:106474118chr4:106320321ENST00000420470+114713_77665778.0DomainSH3 2
HgeneARHGEF38chr4:106474118chr4:106320321ENST00000420470+11494_28565778.0DomainDH


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Fusion Gene Sequence for ARHGEF38-PPA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6303_6303_1_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000265154_PPA2_chr4_106320321_ENST00000341695_length(transcript)=1340nt_BP=342nt
AGTCACAGCCAGGTAACCCTGGAGTGAAGCGGTTTAGTTAGAAGGGAGCAGATAAACTCGTCACTCTAGTAGCTTTAACCCTCACCCTGA
GGCACCTTAGCAATCAGCCATTGCCTGCAAGCCTCCAAAGCTTGTCTTTGCCTAATATGGAGCCCAAAGAAGCCACTGGGAAAGAAAACA
TGGTCACCAAGAAAAAGAATCTGGCCTTCTTGAGGTCTAGACTCTATATGCTGGAGAGAAGGAAGACTGACACTGTGGTTGAGAGCAGTG
TTTCTGGGGACCACTCTGGCACCTTGAGGAGGAGCCAATCTGACAGGACTGAATACAACCAGAAATTACAAGATATTGATGATGTTAAGA
AGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTA
ATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATG
GAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTAT
CATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAG
ATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTT
TTTGAGCTATGCAATATATAAATAAACAGTAAGAATTTTAAATTACTCTCCTTTGGACATTTATTGATATAAAAAGAAGATTTTGGCCAG
GCACGGTGGCTCATGCCTGTAATTTCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAGT
ATGTTGAAACCCCATCTCTATTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGCATGCCTGTAGACCCAGCTACTCAGGAGGCTGAGGC
AGAAGAACTGCTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCAGAGATTGTGCCACTGCACTCCAGCCTAGGCGACAGAGAGAGACTCCG
TCTCAAAAAAAAAAAAAAGATTTTGTTTCATTTCATAGCACAAATTTAGAGGCATTGAGTTGACCATTTCTAGTTTCTATACCTGAAGGA

>6303_6303_1_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000265154_PPA2_chr4_106320321_ENST00000341695_length(amino acids)=201AA_BP=85
MRHLSNQPLPASLQSLSLPNMEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQDIDDV
KKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVES

--------------------------------------------------------------
>6303_6303_2_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000265154_PPA2_chr4_106320321_ENST00000348706_length(transcript)=1174nt_BP=342nt
AGTCACAGCCAGGTAACCCTGGAGTGAAGCGGTTTAGTTAGAAGGGAGCAGATAAACTCGTCACTCTAGTAGCTTTAACCCTCACCCTGA
GGCACCTTAGCAATCAGCCATTGCCTGCAAGCCTCCAAAGCTTGTCTTTGCCTAATATGGAGCCCAAAGAAGCCACTGGGAAAGAAAACA
TGGTCACCAAGAAAAAGAATCTGGCCTTCTTGAGGTCTAGACTCTATATGCTGGAGAGAAGGAAGACTGACACTGTGGTTGAGAGCAGTG
TTTCTGGGGACCACTCTGGCACCTTGAGGAGGAGCCAATCTGACAGGACTGAATACAACCAGAAATTACAAGATATTGATGATGTTAAGA
AGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTA
ATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATG
GAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTAT
CATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAG
ATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTT
TTTGAGCTATGCAATATATAAATAAACAGTAAGAATTTTAAATTACTCTCCTTTGGACATTTATTGATATAAAAAGAAGATTTTGGCCAG
GCACGGTGGCTCATGCCTGTAATTTCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAGT
ATGTTGAAACCCCATCTCTATTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGCATGCCTGTAGACCCAGCTACTCAGGAGGCTGAGGC
AGAAGAACTGCTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCAGAGATTGTGCCACTGCACTCCAGCCTAGGCGACAGAGAGAGACTCCG

>6303_6303_2_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000265154_PPA2_chr4_106320321_ENST00000348706_length(amino acids)=201AA_BP=85
MRHLSNQPLPASLQSLSLPNMEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQDIDDV
KKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVES

--------------------------------------------------------------
>6303_6303_3_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000265154_PPA2_chr4_106320321_ENST00000354147_length(transcript)=852nt_BP=342nt
AGTCACAGCCAGGTAACCCTGGAGTGAAGCGGTTTAGTTAGAAGGGAGCAGATAAACTCGTCACTCTAGTAGCTTTAACCCTCACCCTGA
GGCACCTTAGCAATCAGCCATTGCCTGCAAGCCTCCAAAGCTTGTCTTTGCCTAATATGGAGCCCAAAGAAGCCACTGGGAAAGAAAACA
TGGTCACCAAGAAAAAGAATCTGGCCTTCTTGAGGTCTAGACTCTATATGCTGGAGAGAAGGAAGACTGACACTGTGGTTGAGAGCAGTG
TTTCTGGGGACCACTCTGGCACCTTGAGGAGGAGCCAATCTGACAGGACTGAATACAACCAGAAATTACAAGATATTGATGATGTTAAGA
AGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTA
ATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATG
GAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTAT
CATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAG
ATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTT

>6303_6303_3_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000265154_PPA2_chr4_106320321_ENST00000354147_length(amino acids)=201AA_BP=85
MRHLSNQPLPASLQSLSLPNMEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQDIDDV
KKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVES

--------------------------------------------------------------
>6303_6303_4_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000265154_PPA2_chr4_106320321_ENST00000357415_length(transcript)=849nt_BP=342nt
AGTCACAGCCAGGTAACCCTGGAGTGAAGCGGTTTAGTTAGAAGGGAGCAGATAAACTCGTCACTCTAGTAGCTTTAACCCTCACCCTGA
GGCACCTTAGCAATCAGCCATTGCCTGCAAGCCTCCAAAGCTTGTCTTTGCCTAATATGGAGCCCAAAGAAGCCACTGGGAAAGAAAACA
TGGTCACCAAGAAAAAGAATCTGGCCTTCTTGAGGTCTAGACTCTATATGCTGGAGAGAAGGAAGACTGACACTGTGGTTGAGAGCAGTG
TTTCTGGGGACCACTCTGGCACCTTGAGGAGGAGCCAATCTGACAGGACTGAATACAACCAGAAATTACAAGATATTGATGATGTTAAGA
AGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTA
ATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATG
GAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTAT
CATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAG
ATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTT

>6303_6303_4_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000265154_PPA2_chr4_106320321_ENST00000357415_length(amino acids)=201AA_BP=85
MRHLSNQPLPASLQSLSLPNMEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQDIDDV
KKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVES

--------------------------------------------------------------
>6303_6303_5_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000265154_PPA2_chr4_106320321_ENST00000380004_length(transcript)=849nt_BP=342nt
AGTCACAGCCAGGTAACCCTGGAGTGAAGCGGTTTAGTTAGAAGGGAGCAGATAAACTCGTCACTCTAGTAGCTTTAACCCTCACCCTGA
GGCACCTTAGCAATCAGCCATTGCCTGCAAGCCTCCAAAGCTTGTCTTTGCCTAATATGGAGCCCAAAGAAGCCACTGGGAAAGAAAACA
TGGTCACCAAGAAAAAGAATCTGGCCTTCTTGAGGTCTAGACTCTATATGCTGGAGAGAAGGAAGACTGACACTGTGGTTGAGAGCAGTG
TTTCTGGGGACCACTCTGGCACCTTGAGGAGGAGCCAATCTGACAGGACTGAATACAACCAGAAATTACAAGATATTGATGATGTTAAGA
AGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTA
ATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATG
GAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTAT
CATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAG
ATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTT

>6303_6303_5_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000265154_PPA2_chr4_106320321_ENST00000380004_length(amino acids)=201AA_BP=85
MRHLSNQPLPASLQSLSLPNMEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQDIDDV
KKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVES

--------------------------------------------------------------
>6303_6303_6_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000265154_PPA2_chr4_106320321_ENST00000432483_length(transcript)=852nt_BP=342nt
AGTCACAGCCAGGTAACCCTGGAGTGAAGCGGTTTAGTTAGAAGGGAGCAGATAAACTCGTCACTCTAGTAGCTTTAACCCTCACCCTGA
GGCACCTTAGCAATCAGCCATTGCCTGCAAGCCTCCAAAGCTTGTCTTTGCCTAATATGGAGCCCAAAGAAGCCACTGGGAAAGAAAACA
TGGTCACCAAGAAAAAGAATCTGGCCTTCTTGAGGTCTAGACTCTATATGCTGGAGAGAAGGAAGACTGACACTGTGGTTGAGAGCAGTG
TTTCTGGGGACCACTCTGGCACCTTGAGGAGGAGCCAATCTGACAGGACTGAATACAACCAGAAATTACAAGATATTGATGATGTTAAGA
AGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTA
ATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATG
GAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTAT
CATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAG
ATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTT

>6303_6303_6_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000265154_PPA2_chr4_106320321_ENST00000432483_length(amino acids)=201AA_BP=85
MRHLSNQPLPASLQSLSLPNMEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQDIDDV
KKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVES

--------------------------------------------------------------
>6303_6303_7_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000420470_PPA2_chr4_106320321_ENST00000341695_length(transcript)=1338nt_BP=340nt
TCACAGCCAGGTAACCCTGGAGTGAAGCGGTTTAGTTAGAAGGGAGCAGATAAACTCGTCACTCTAGTAGCTTTAACCCTCACCCTGAGG
CACCTTAGCAATCAGCCATTGCCTGCAAGCCTCCAAAGCTTGTCTTTGCCTAATATGGAGCCCAAAGAAGCCACTGGGAAAGAAAACATG
GTCACCAAGAAAAAGAATCTGGCCTTCTTGAGGTCTAGACTCTATATGCTGGAGAGAAGGAAGACTGACACTGTGGTTGAGAGCAGTGTT
TCTGGGGACCACTCTGGCACCTTGAGGAGGAGCCAATCTGACAGGACTGAATACAACCAGAAATTACAAGATATTGATGATGTTAAGAAG
TTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTAAT
GGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATGGA
GGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTATCA
TCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAGAT
TCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTTTT
TGAGCTATGCAATATATAAATAAACAGTAAGAATTTTAAATTACTCTCCTTTGGACATTTATTGATATAAAAAGAAGATTTTGGCCAGGC
ACGGTGGCTCATGCCTGTAATTTCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAGTAT
GTTGAAACCCCATCTCTATTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGCATGCCTGTAGACCCAGCTACTCAGGAGGCTGAGGCAG
AAGAACTGCTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCAGAGATTGTGCCACTGCACTCCAGCCTAGGCGACAGAGAGAGACTCCGTC
TCAAAAAAAAAAAAAAGATTTTGTTTCATTTCATAGCACAAATTTAGAGGCATTGAGTTGACCATTTCTAGTTTCTATACCTGAAGGAAC

>6303_6303_7_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000420470_PPA2_chr4_106320321_ENST00000341695_length(amino acids)=201AA_BP=85
MRHLSNQPLPASLQSLSLPNMEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQDIDDV
KKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVES

--------------------------------------------------------------
>6303_6303_8_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000420470_PPA2_chr4_106320321_ENST00000348706_length(transcript)=1172nt_BP=340nt
TCACAGCCAGGTAACCCTGGAGTGAAGCGGTTTAGTTAGAAGGGAGCAGATAAACTCGTCACTCTAGTAGCTTTAACCCTCACCCTGAGG
CACCTTAGCAATCAGCCATTGCCTGCAAGCCTCCAAAGCTTGTCTTTGCCTAATATGGAGCCCAAAGAAGCCACTGGGAAAGAAAACATG
GTCACCAAGAAAAAGAATCTGGCCTTCTTGAGGTCTAGACTCTATATGCTGGAGAGAAGGAAGACTGACACTGTGGTTGAGAGCAGTGTT
TCTGGGGACCACTCTGGCACCTTGAGGAGGAGCCAATCTGACAGGACTGAATACAACCAGAAATTACAAGATATTGATGATGTTAAGAAG
TTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTAAT
GGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATGGA
GGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTATCA
TCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAGAT
TCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTTTT
TGAGCTATGCAATATATAAATAAACAGTAAGAATTTTAAATTACTCTCCTTTGGACATTTATTGATATAAAAAGAAGATTTTGGCCAGGC
ACGGTGGCTCATGCCTGTAATTTCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAGTAT
GTTGAAACCCCATCTCTATTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGCATGCCTGTAGACCCAGCTACTCAGGAGGCTGAGGCAG
AAGAACTGCTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCAGAGATTGTGCCACTGCACTCCAGCCTAGGCGACAGAGAGAGACTCCGTC

>6303_6303_8_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000420470_PPA2_chr4_106320321_ENST00000348706_length(amino acids)=201AA_BP=85
MRHLSNQPLPASLQSLSLPNMEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQDIDDV
KKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVES

--------------------------------------------------------------
>6303_6303_9_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000420470_PPA2_chr4_106320321_ENST00000354147_length(transcript)=850nt_BP=340nt
TCACAGCCAGGTAACCCTGGAGTGAAGCGGTTTAGTTAGAAGGGAGCAGATAAACTCGTCACTCTAGTAGCTTTAACCCTCACCCTGAGG
CACCTTAGCAATCAGCCATTGCCTGCAAGCCTCCAAAGCTTGTCTTTGCCTAATATGGAGCCCAAAGAAGCCACTGGGAAAGAAAACATG
GTCACCAAGAAAAAGAATCTGGCCTTCTTGAGGTCTAGACTCTATATGCTGGAGAGAAGGAAGACTGACACTGTGGTTGAGAGCAGTGTT
TCTGGGGACCACTCTGGCACCTTGAGGAGGAGCCAATCTGACAGGACTGAATACAACCAGAAATTACAAGATATTGATGATGTTAAGAAG
TTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTAAT
GGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATGGA
GGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTATCA
TCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAGAT
TCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTTTT

>6303_6303_9_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000420470_PPA2_chr4_106320321_ENST00000354147_length(amino acids)=201AA_BP=85
MRHLSNQPLPASLQSLSLPNMEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQDIDDV
KKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVES

--------------------------------------------------------------
>6303_6303_10_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000420470_PPA2_chr4_106320321_ENST00000357415_length(transcript)=847nt_BP=340nt
TCACAGCCAGGTAACCCTGGAGTGAAGCGGTTTAGTTAGAAGGGAGCAGATAAACTCGTCACTCTAGTAGCTTTAACCCTCACCCTGAGG
CACCTTAGCAATCAGCCATTGCCTGCAAGCCTCCAAAGCTTGTCTTTGCCTAATATGGAGCCCAAAGAAGCCACTGGGAAAGAAAACATG
GTCACCAAGAAAAAGAATCTGGCCTTCTTGAGGTCTAGACTCTATATGCTGGAGAGAAGGAAGACTGACACTGTGGTTGAGAGCAGTGTT
TCTGGGGACCACTCTGGCACCTTGAGGAGGAGCCAATCTGACAGGACTGAATACAACCAGAAATTACAAGATATTGATGATGTTAAGAAG
TTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTAAT
GGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATGGA
GGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTATCA
TCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAGAT
TCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTTTT

>6303_6303_10_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000420470_PPA2_chr4_106320321_ENST00000357415_length(amino acids)=201AA_BP=85
MRHLSNQPLPASLQSLSLPNMEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQDIDDV
KKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVES

--------------------------------------------------------------
>6303_6303_11_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000420470_PPA2_chr4_106320321_ENST00000380004_length(transcript)=847nt_BP=340nt
TCACAGCCAGGTAACCCTGGAGTGAAGCGGTTTAGTTAGAAGGGAGCAGATAAACTCGTCACTCTAGTAGCTTTAACCCTCACCCTGAGG
CACCTTAGCAATCAGCCATTGCCTGCAAGCCTCCAAAGCTTGTCTTTGCCTAATATGGAGCCCAAAGAAGCCACTGGGAAAGAAAACATG
GTCACCAAGAAAAAGAATCTGGCCTTCTTGAGGTCTAGACTCTATATGCTGGAGAGAAGGAAGACTGACACTGTGGTTGAGAGCAGTGTT
TCTGGGGACCACTCTGGCACCTTGAGGAGGAGCCAATCTGACAGGACTGAATACAACCAGAAATTACAAGATATTGATGATGTTAAGAAG
TTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTAAT
GGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATGGA
GGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTATCA
TCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAGAT
TCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTTTT

>6303_6303_11_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000420470_PPA2_chr4_106320321_ENST00000380004_length(amino acids)=201AA_BP=85
MRHLSNQPLPASLQSLSLPNMEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQDIDDV
KKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVES

--------------------------------------------------------------
>6303_6303_12_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000420470_PPA2_chr4_106320321_ENST00000432483_length(transcript)=850nt_BP=340nt
TCACAGCCAGGTAACCCTGGAGTGAAGCGGTTTAGTTAGAAGGGAGCAGATAAACTCGTCACTCTAGTAGCTTTAACCCTCACCCTGAGG
CACCTTAGCAATCAGCCATTGCCTGCAAGCCTCCAAAGCTTGTCTTTGCCTAATATGGAGCCCAAAGAAGCCACTGGGAAAGAAAACATG
GTCACCAAGAAAAAGAATCTGGCCTTCTTGAGGTCTAGACTCTATATGCTGGAGAGAAGGAAGACTGACACTGTGGTTGAGAGCAGTGTT
TCTGGGGACCACTCTGGCACCTTGAGGAGGAGCCAATCTGACAGGACTGAATACAACCAGAAATTACAAGATATTGATGATGTTAAGAAG
TTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTAAT
GGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATGGA
GGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTATCA
TCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAGAT
TCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTTTT

>6303_6303_12_ARHGEF38-PPA2_ARHGEF38_chr4_106474118_ENST00000420470_PPA2_chr4_106320321_ENST00000432483_length(amino acids)=201AA_BP=85
MRHLSNQPLPASLQSLSLPNMEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQDIDDV
KKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVES

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGEF38-PPA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF38-PPA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF38-PPA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource