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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PCBD2-CHGA (FusionGDB2 ID:63079)

Fusion Gene Summary for PCBD2-CHGA

Fusion gene summary

Fusion gene information	Fusion gene name: PCBD2-CHGA
	Fusion gene ID: 63079
		Hgene	Tgene
	Gene symbol	PCBD2	CHGA
	Gene ID	84105	1113
	Gene name	pterin-4 alpha-carbinolamine dehydratase 2	chromogranin A
	Synonyms	DCOH2\|DCOHM\|PHS2	CGA
	Cytomap	5q31.1	14q32.12
	Type of gene	protein-coding	protein-coding
	Description	pterin-4-alpha-carbinolamine dehydratase 24-alpha-hydroxy-tetrahydropterin dehydratase 26-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2DcoH-like protein DCoHmHNF-1-alpha dimerization cofactorPH	chromogranin-ASP-Ibetagranin (N-terminal fragment of chromogranin A)catestatinchromofunginparathyroid secretory protein 1pituitary secretory protein I
	Modification date	20200313	20200315
	UniProtAcc	.	P10645
	Ensembl transtripts involved in fusion gene	ENST00000254908, ENST00000510013, ENST00000512783,	ENST00000216492, ENST00000334654, ENST00000553866,
Fusion gene scores	* DoF score	15 X 64 X 7=6720	14 X 26 X 3=1092
	# samples	40	19
	** MAII score	log2(40/6720*10)=-4.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/1092*10)=-2.5229015325889 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PCBD2 [Title/Abstract] AND CHGA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PCBD2(134259678)-CHGA(93398869), # samples:3 PCBD2(134264009)-CHGA(93398983), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PCBD2	GO:0045893	positive regulation of transcription, DNA-templated	11980910
Tgene	CHGA	GO:0002551	mast cell chemotaxis	21214543
Tgene	CHGA	GO:0032762	mast cell cytokine production	21214543
Tgene	CHGA	GO:0033604	negative regulation of catecholamine secretion	15326220
Tgene	CHGA	GO:0043303	mast cell degranulation	21214543
Tgene	CHGA	GO:0045576	mast cell activation	21214543
Tgene	CHGA	GO:0050829	defense response to Gram-negative bacterium	15723172
Tgene	CHGA	GO:0050830	defense response to Gram-positive bacterium	15723172

Fusion gene breakpoints across PCBD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CHGA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PCPG	TCGA-QR-A6GX-01A	PCBD2	chr5	134259678	+	CHGA	chr14	93398869	+
ChimerDB4	PCPG	TCGA-QR-A6GX-01A	PCBD2	chr5	134260380	+	CHGA	chr14	93398869	+
ChimerDB4	PCPG	TCGA-QR-A6GX-01A	PCBD2	chr5	134260669	+	CHGA	chr14	93397842	+
ChimerDB4	PCPG	TCGA-QR-A6GX-01A	PCBD2	chr5	134263504	+	CHGA	chr14	93398822	+
ChimerDB4	PCPG	TCGA-QR-A6GX-01A	PCBD2	chr5	134263633	+	CHGA	chr14	93398732	+
ChimerDB4	PCPG	TCGA-QR-A6GX-01A	PCBD2	chr5	134264009	+	CHGA	chr14	93398983	+
ChimerDB4	PCPG	TCGA-QT-A7U0-01A	PCBD2	chr5	134259678	+	CHGA	chr14	93398869	+
ChimerDB4	PCPG	TCGA-QT-A7U0-01A	PCBD2	chr5	134264009	+	CHGA	chr14	93398983	+
ChimerDB4	PCPG	TCGA-RW-A688-01A	PCBD2	chr5	134259224	+	CHGA	chr14	93398868	+
ChimerDB4	PCPG	TCGA-RW-A688-01A	PCBD2	chr5	134262628	+	CHGA	chr14	93398714	+
ChimerDB4	PCPG	TCGA-RW-A688-01A	PCBD2	chr5	134262816	+	CHGA	chr14	93398824	+
ChimerDB4	PCPG	TCGA-RW-A688-01A	PCBD2	chr5	134263447	+	CHGA	chr14	93397660	+
ChimerDB4	PCPG	TCGA-RW-A7CZ-01A	PCBD2	chr5	134259165	+	CHGA	chr14	93397952	+
ChimerDB4	PCPG	TCGA-RW-A7CZ-01A	PCBD2	chr5	134259678	+	CHGA	chr14	93398869	+
ChimerDB4	PCPG	TCGA-RW-A7CZ-01A	PCBD2	chr5	134260430	+	CHGA	chr14	93398824	+
ChimerDB4	PCPG	TCGA-RW-A7CZ-01A	PCBD2	chr5	134262497	+	CHGA	chr14	93397955	+
ChimerDB4	PCPG	TCGA-RW-A7CZ-01A	PCBD2	chr5	134264009	+	CHGA	chr14	93398983	+

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Fusion Gene ORF analysis for PCBD2-CHGA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000254908	ENST00000216492	PCBD2	chr5	134260380	+	CHGA	chr14	93398869	+
intron-3CDS	ENST00000254908	ENST00000216492	PCBD2	chr5	134260669	+	CHGA	chr14	93397842	+
intron-3CDS	ENST00000254908	ENST00000216492	PCBD2	chr5	134263504	+	CHGA	chr14	93398822	+
intron-3CDS	ENST00000254908	ENST00000216492	PCBD2	chr5	134263633	+	CHGA	chr14	93398732	+
intron-3CDS	ENST00000254908	ENST00000216492	PCBD2	chr5	134259678	+	CHGA	chr14	93398869	+
intron-3CDS	ENST00000254908	ENST00000216492	PCBD2	chr5	134264009	+	CHGA	chr14	93398983	+
intron-3CDS	ENST00000254908	ENST00000216492	PCBD2	chr5	134259224	+	CHGA	chr14	93398868	+
intron-3CDS	ENST00000254908	ENST00000216492	PCBD2	chr5	134262628	+	CHGA	chr14	93398714	+
intron-3CDS	ENST00000254908	ENST00000216492	PCBD2	chr5	134262816	+	CHGA	chr14	93398824	+
intron-3CDS	ENST00000254908	ENST00000216492	PCBD2	chr5	134263447	+	CHGA	chr14	93397660	+
intron-3CDS	ENST00000254908	ENST00000216492	PCBD2	chr5	134259165	+	CHGA	chr14	93397952	+
intron-3CDS	ENST00000254908	ENST00000216492	PCBD2	chr5	134260430	+	CHGA	chr14	93398824	+
intron-3CDS	ENST00000254908	ENST00000216492	PCBD2	chr5	134262497	+	CHGA	chr14	93397955	+
intron-3CDS	ENST00000254908	ENST00000334654	PCBD2	chr5	134260380	+	CHGA	chr14	93398869	+
intron-3CDS	ENST00000254908	ENST00000334654	PCBD2	chr5	134263504	+	CHGA	chr14	93398822	+
intron-3CDS	ENST00000254908	ENST00000334654	PCBD2	chr5	134263633	+	CHGA	chr14	93398732	+
intron-3CDS	ENST00000254908	ENST00000334654	PCBD2	chr5	134259678	+	CHGA	chr14	93398869	+
intron-3CDS	ENST00000254908	ENST00000334654	PCBD2	chr5	134264009	+	CHGA	chr14	93398983	+
intron-3CDS	ENST00000254908	ENST00000334654	PCBD2	chr5	134259224	+	CHGA	chr14	93398868	+
intron-3CDS	ENST00000254908	ENST00000334654	PCBD2	chr5	134262628	+	CHGA	chr14	93398714	+
intron-3CDS	ENST00000254908	ENST00000334654	PCBD2	chr5	134262816	+	CHGA	chr14	93398824	+
intron-3CDS	ENST00000254908	ENST00000334654	PCBD2	chr5	134260430	+	CHGA	chr14	93398824	+
intron-3CDS	ENST00000510013	ENST00000216492	PCBD2	chr5	134260380	+	CHGA	chr14	93398869	+
intron-3CDS	ENST00000510013	ENST00000216492	PCBD2	chr5	134260669	+	CHGA	chr14	93397842	+
intron-3CDS	ENST00000510013	ENST00000216492	PCBD2	chr5	134263504	+	CHGA	chr14	93398822	+
intron-3CDS	ENST00000510013	ENST00000216492	PCBD2	chr5	134263633	+	CHGA	chr14	93398732	+
intron-3CDS	ENST00000510013	ENST00000216492	PCBD2	chr5	134259678	+	CHGA	chr14	93398869	+
intron-3CDS	ENST00000510013	ENST00000216492	PCBD2	chr5	134264009	+	CHGA	chr14	93398983	+
intron-3CDS	ENST00000510013	ENST00000216492	PCBD2	chr5	134259224	+	CHGA	chr14	93398868	+
intron-3CDS	ENST00000510013	ENST00000216492	PCBD2	chr5	134262628	+	CHGA	chr14	93398714	+
intron-3CDS	ENST00000510013	ENST00000216492	PCBD2	chr5	134262816	+	CHGA	chr14	93398824	+
intron-3CDS	ENST00000510013	ENST00000216492	PCBD2	chr5	134263447	+	CHGA	chr14	93397660	+
intron-3CDS	ENST00000510013	ENST00000216492	PCBD2	chr5	134259165	+	CHGA	chr14	93397952	+
intron-3CDS	ENST00000510013	ENST00000216492	PCBD2	chr5	134260430	+	CHGA	chr14	93398824	+
intron-3CDS	ENST00000510013	ENST00000216492	PCBD2	chr5	134262497	+	CHGA	chr14	93397955	+
intron-3CDS	ENST00000510013	ENST00000334654	PCBD2	chr5	134260380	+	CHGA	chr14	93398869	+
intron-3CDS	ENST00000510013	ENST00000334654	PCBD2	chr5	134263504	+	CHGA	chr14	93398822	+
intron-3CDS	ENST00000510013	ENST00000334654	PCBD2	chr5	134263633	+	CHGA	chr14	93398732	+
intron-3CDS	ENST00000510013	ENST00000334654	PCBD2	chr5	134259678	+	CHGA	chr14	93398869	+
intron-3CDS	ENST00000510013	ENST00000334654	PCBD2	chr5	134264009	+	CHGA	chr14	93398983	+
intron-3CDS	ENST00000510013	ENST00000334654	PCBD2	chr5	134259224	+	CHGA	chr14	93398868	+
intron-3CDS	ENST00000510013	ENST00000334654	PCBD2	chr5	134262628	+	CHGA	chr14	93398714	+
intron-3CDS	ENST00000510013	ENST00000334654	PCBD2	chr5	134262816	+	CHGA	chr14	93398824	+
intron-3CDS	ENST00000510013	ENST00000334654	PCBD2	chr5	134260430	+	CHGA	chr14	93398824	+
intron-3CDS	ENST00000512783	ENST00000216492	PCBD2	chr5	134260380	+	CHGA	chr14	93398869	+
intron-3CDS	ENST00000512783	ENST00000216492	PCBD2	chr5	134260669	+	CHGA	chr14	93397842	+
intron-3CDS	ENST00000512783	ENST00000216492	PCBD2	chr5	134263504	+	CHGA	chr14	93398822	+
intron-3CDS	ENST00000512783	ENST00000216492	PCBD2	chr5	134263633	+	CHGA	chr14	93398732	+
intron-3CDS	ENST00000512783	ENST00000216492	PCBD2	chr5	134259678	+	CHGA	chr14	93398869	+
intron-3CDS	ENST00000512783	ENST00000216492	PCBD2	chr5	134264009	+	CHGA	chr14	93398983	+
intron-3CDS	ENST00000512783	ENST00000216492	PCBD2	chr5	134259224	+	CHGA	chr14	93398868	+
intron-3CDS	ENST00000512783	ENST00000216492	PCBD2	chr5	134262628	+	CHGA	chr14	93398714	+
intron-3CDS	ENST00000512783	ENST00000216492	PCBD2	chr5	134262816	+	CHGA	chr14	93398824	+
intron-3CDS	ENST00000512783	ENST00000216492	PCBD2	chr5	134263447	+	CHGA	chr14	93397660	+
intron-3CDS	ENST00000512783	ENST00000216492	PCBD2	chr5	134259165	+	CHGA	chr14	93397952	+
intron-3CDS	ENST00000512783	ENST00000216492	PCBD2	chr5	134260430	+	CHGA	chr14	93398824	+
intron-3CDS	ENST00000512783	ENST00000216492	PCBD2	chr5	134262497	+	CHGA	chr14	93397955	+
intron-3CDS	ENST00000512783	ENST00000334654	PCBD2	chr5	134260380	+	CHGA	chr14	93398869	+
intron-3CDS	ENST00000512783	ENST00000334654	PCBD2	chr5	134263504	+	CHGA	chr14	93398822	+
intron-3CDS	ENST00000512783	ENST00000334654	PCBD2	chr5	134263633	+	CHGA	chr14	93398732	+
intron-3CDS	ENST00000512783	ENST00000334654	PCBD2	chr5	134259678	+	CHGA	chr14	93398869	+
intron-3CDS	ENST00000512783	ENST00000334654	PCBD2	chr5	134264009	+	CHGA	chr14	93398983	+
intron-3CDS	ENST00000512783	ENST00000334654	PCBD2	chr5	134259224	+	CHGA	chr14	93398868	+
intron-3CDS	ENST00000512783	ENST00000334654	PCBD2	chr5	134262628	+	CHGA	chr14	93398714	+
intron-3CDS	ENST00000512783	ENST00000334654	PCBD2	chr5	134262816	+	CHGA	chr14	93398824	+
intron-3CDS	ENST00000512783	ENST00000334654	PCBD2	chr5	134260430	+	CHGA	chr14	93398824	+
intron-3UTR	ENST00000254908	ENST00000553866	PCBD2	chr5	134260669	+	CHGA	chr14	93397842	+
intron-3UTR	ENST00000254908	ENST00000553866	PCBD2	chr5	134263447	+	CHGA	chr14	93397660	+
intron-3UTR	ENST00000254908	ENST00000553866	PCBD2	chr5	134259165	+	CHGA	chr14	93397952	+
intron-3UTR	ENST00000254908	ENST00000553866	PCBD2	chr5	134262497	+	CHGA	chr14	93397955	+
intron-3UTR	ENST00000510013	ENST00000553866	PCBD2	chr5	134260669	+	CHGA	chr14	93397842	+
intron-3UTR	ENST00000510013	ENST00000553866	PCBD2	chr5	134263447	+	CHGA	chr14	93397660	+
intron-3UTR	ENST00000510013	ENST00000553866	PCBD2	chr5	134259165	+	CHGA	chr14	93397952	+
intron-3UTR	ENST00000510013	ENST00000553866	PCBD2	chr5	134262497	+	CHGA	chr14	93397955	+
intron-3UTR	ENST00000512783	ENST00000553866	PCBD2	chr5	134260669	+	CHGA	chr14	93397842	+
intron-3UTR	ENST00000512783	ENST00000553866	PCBD2	chr5	134263447	+	CHGA	chr14	93397660	+
intron-3UTR	ENST00000512783	ENST00000553866	PCBD2	chr5	134259165	+	CHGA	chr14	93397952	+
intron-3UTR	ENST00000512783	ENST00000553866	PCBD2	chr5	134262497	+	CHGA	chr14	93397955	+
intron-intron	ENST00000254908	ENST00000334654	PCBD2	chr5	134260669	+	CHGA	chr14	93397842	+
intron-intron	ENST00000254908	ENST00000334654	PCBD2	chr5	134263447	+	CHGA	chr14	93397660	+
intron-intron	ENST00000254908	ENST00000334654	PCBD2	chr5	134259165	+	CHGA	chr14	93397952	+
intron-intron	ENST00000254908	ENST00000334654	PCBD2	chr5	134262497	+	CHGA	chr14	93397955	+
intron-intron	ENST00000254908	ENST00000553866	PCBD2	chr5	134260380	+	CHGA	chr14	93398869	+
intron-intron	ENST00000254908	ENST00000553866	PCBD2	chr5	134263504	+	CHGA	chr14	93398822	+
intron-intron	ENST00000254908	ENST00000553866	PCBD2	chr5	134263633	+	CHGA	chr14	93398732	+
intron-intron	ENST00000254908	ENST00000553866	PCBD2	chr5	134259678	+	CHGA	chr14	93398869	+
intron-intron	ENST00000254908	ENST00000553866	PCBD2	chr5	134264009	+	CHGA	chr14	93398983	+
intron-intron	ENST00000254908	ENST00000553866	PCBD2	chr5	134259224	+	CHGA	chr14	93398868	+
intron-intron	ENST00000254908	ENST00000553866	PCBD2	chr5	134262628	+	CHGA	chr14	93398714	+
intron-intron	ENST00000254908	ENST00000553866	PCBD2	chr5	134262816	+	CHGA	chr14	93398824	+
intron-intron	ENST00000254908	ENST00000553866	PCBD2	chr5	134260430	+	CHGA	chr14	93398824	+
intron-intron	ENST00000510013	ENST00000334654	PCBD2	chr5	134260669	+	CHGA	chr14	93397842	+
intron-intron	ENST00000510013	ENST00000334654	PCBD2	chr5	134263447	+	CHGA	chr14	93397660	+
intron-intron	ENST00000510013	ENST00000334654	PCBD2	chr5	134259165	+	CHGA	chr14	93397952	+
intron-intron	ENST00000510013	ENST00000334654	PCBD2	chr5	134262497	+	CHGA	chr14	93397955	+
intron-intron	ENST00000510013	ENST00000553866	PCBD2	chr5	134260380	+	CHGA	chr14	93398869	+
intron-intron	ENST00000510013	ENST00000553866	PCBD2	chr5	134263504	+	CHGA	chr14	93398822	+
intron-intron	ENST00000510013	ENST00000553866	PCBD2	chr5	134263633	+	CHGA	chr14	93398732	+
intron-intron	ENST00000510013	ENST00000553866	PCBD2	chr5	134259678	+	CHGA	chr14	93398869	+
intron-intron	ENST00000510013	ENST00000553866	PCBD2	chr5	134264009	+	CHGA	chr14	93398983	+
intron-intron	ENST00000510013	ENST00000553866	PCBD2	chr5	134259224	+	CHGA	chr14	93398868	+
intron-intron	ENST00000510013	ENST00000553866	PCBD2	chr5	134262628	+	CHGA	chr14	93398714	+
intron-intron	ENST00000510013	ENST00000553866	PCBD2	chr5	134262816	+	CHGA	chr14	93398824	+
intron-intron	ENST00000510013	ENST00000553866	PCBD2	chr5	134260430	+	CHGA	chr14	93398824	+
intron-intron	ENST00000512783	ENST00000334654	PCBD2	chr5	134260669	+	CHGA	chr14	93397842	+
intron-intron	ENST00000512783	ENST00000334654	PCBD2	chr5	134263447	+	CHGA	chr14	93397660	+
intron-intron	ENST00000512783	ENST00000334654	PCBD2	chr5	134259165	+	CHGA	chr14	93397952	+
intron-intron	ENST00000512783	ENST00000334654	PCBD2	chr5	134262497	+	CHGA	chr14	93397955	+
intron-intron	ENST00000512783	ENST00000553866	PCBD2	chr5	134260380	+	CHGA	chr14	93398869	+
intron-intron	ENST00000512783	ENST00000553866	PCBD2	chr5	134263504	+	CHGA	chr14	93398822	+
intron-intron	ENST00000512783	ENST00000553866	PCBD2	chr5	134263633	+	CHGA	chr14	93398732	+
intron-intron	ENST00000512783	ENST00000553866	PCBD2	chr5	134259678	+	CHGA	chr14	93398869	+
intron-intron	ENST00000512783	ENST00000553866	PCBD2	chr5	134264009	+	CHGA	chr14	93398983	+
intron-intron	ENST00000512783	ENST00000553866	PCBD2	chr5	134259224	+	CHGA	chr14	93398868	+
intron-intron	ENST00000512783	ENST00000553866	PCBD2	chr5	134262628	+	CHGA	chr14	93398714	+
intron-intron	ENST00000512783	ENST00000553866	PCBD2	chr5	134262816	+	CHGA	chr14	93398824	+
intron-intron	ENST00000512783	ENST00000553866	PCBD2	chr5	134260430	+	CHGA	chr14	93398824	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for PCBD2-CHGA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PCBD2-CHGA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:134259678/:93398869)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CHGA P10645
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269\|PubMed:15326220, ECO:0000269\|PubMed:15723172, ECO:0000269\|PubMed:21214543, ECO:0000269\|PubMed:24723458, ECO:0000303\|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250\|UniProtKB:P26339}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for PCBD2-CHGA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PCBD2-CHGA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PCBD2-CHGA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PCBD2-CHGA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source