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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARHGEF3-ACP6 (FusionGDB2 ID:6308)

Fusion Gene Summary for ARHGEF3-ACP6

Fusion gene summary

Fusion gene information	Fusion gene name: ARHGEF3-ACP6
	Fusion gene ID: 6308
		Hgene	Tgene
	Gene symbol	ARHGEF3	ACP6
	Gene ID	50650	51205
	Gene name	Rho guanine nucleotide exchange factor 3	acid phosphatase 6, lysophosphatidic
	Synonyms	GEF3\|STA3\|XPLN	ACPL1\|LPAP\|PACPL1
	Cytomap	3p14.3	1q21.2
	Type of gene	protein-coding	protein-coding
	Description	rho guanine nucleotide exchange factor 359.8 kDA proteinRho guanine nucleotide exchange factor (GEF) 3RhoGEF proteinexchange factor found in platelets and leukemic and neuronal tissues, XPLN	lysophosphatidic acid phosphatase type 6acid phosphatase-like protein 1
	Modification date	20200327	20200313
	UniProtAcc	.	Q9NPH0
	Ensembl transtripts involved in fusion gene	ENST00000338458, ENST00000496106, ENST00000498517, ENST00000296315, ENST00000413728, ENST00000495373, ENST00000497267,	ENST00000392988, ENST00000460583, ENST00000369238,
Fusion gene scores	* DoF score	19 X 17 X 8=2584	2 X 2 X 2=8
	# samples	23	3
	** MAII score	log2(23/2584*10)=-3.48990030374955 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/8*10)=1.90689059560852
Context	PubMed: ARHGEF3 [Title/Abstract] AND ACP6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARHGEF3(56916320)-ACP6(147131890), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ACP6	GO:2001311	lysobisphosphatidic acid metabolic process	23807634

Fusion gene breakpoints across ARHGEF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACP6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AO-A0J6-01A	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
ChimerDB4	BRCA	TCGA-AO-A0J6	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-

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Fusion Gene ORF analysis for ARHGEF3-ACP6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000338458	ENST00000392988	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
5CDS-intron	ENST00000338458	ENST00000392988	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
5CDS-intron	ENST00000338458	ENST00000460583	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
5CDS-intron	ENST00000338458	ENST00000460583	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
5CDS-intron	ENST00000496106	ENST00000392988	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
5CDS-intron	ENST00000496106	ENST00000392988	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
5CDS-intron	ENST00000496106	ENST00000460583	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
5CDS-intron	ENST00000496106	ENST00000460583	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
5UTR-3CDS	ENST00000498517	ENST00000369238	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
5UTR-3CDS	ENST00000498517	ENST00000369238	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
5UTR-intron	ENST00000498517	ENST00000392988	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
5UTR-intron	ENST00000498517	ENST00000392988	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
5UTR-intron	ENST00000498517	ENST00000460583	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
5UTR-intron	ENST00000498517	ENST00000460583	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
In-frame	ENST00000338458	ENST00000369238	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
In-frame	ENST00000338458	ENST00000369238	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
In-frame	ENST00000496106	ENST00000369238	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
In-frame	ENST00000496106	ENST00000369238	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
intron-3CDS	ENST00000296315	ENST00000369238	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
intron-3CDS	ENST00000296315	ENST00000369238	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
intron-3CDS	ENST00000413728	ENST00000369238	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
intron-3CDS	ENST00000413728	ENST00000369238	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
intron-3CDS	ENST00000495373	ENST00000369238	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
intron-3CDS	ENST00000495373	ENST00000369238	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
intron-3CDS	ENST00000497267	ENST00000369238	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
intron-3CDS	ENST00000497267	ENST00000369238	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
intron-intron	ENST00000296315	ENST00000392988	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
intron-intron	ENST00000296315	ENST00000392988	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
intron-intron	ENST00000296315	ENST00000460583	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
intron-intron	ENST00000296315	ENST00000460583	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
intron-intron	ENST00000413728	ENST00000392988	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
intron-intron	ENST00000413728	ENST00000392988	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
intron-intron	ENST00000413728	ENST00000460583	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
intron-intron	ENST00000413728	ENST00000460583	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
intron-intron	ENST00000495373	ENST00000392988	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
intron-intron	ENST00000495373	ENST00000392988	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
intron-intron	ENST00000495373	ENST00000460583	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
intron-intron	ENST00000495373	ENST00000460583	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
intron-intron	ENST00000497267	ENST00000392988	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
intron-intron	ENST00000497267	ENST00000392988	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-
intron-intron	ENST00000497267	ENST00000460583	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-
intron-intron	ENST00000497267	ENST00000460583	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000338458	ARHGEF3	chr3	56916320	-	ENST00000369238	ACP6	chr1	147131890	-	6561	302	110	1369	419
ENST00000496106	ARHGEF3	chr3	56916320	-	ENST00000369238	ACP6	chr1	147131890	-	6485	226	82	1293	403
ENST00000338458	ARHGEF3	chr3	56916319	-	ENST00000369238	ACP6	chr1	147131890	-	6561	302	110	1369	419
ENST00000496106	ARHGEF3	chr3	56916319	-	ENST00000369238	ACP6	chr1	147131890	-	6485	226	82	1293	403

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000338458	ENST00000369238	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-	0.000326255	0.9996737
ENST00000496106	ENST00000369238	ARHGEF3	chr3	56916320	-	ACP6	chr1	147131890	-	0.000245573	0.99975437
ENST00000338458	ENST00000369238	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-	0.000326255	0.9996737
ENST00000496106	ENST00000369238	ARHGEF3	chr3	56916319	-	ACP6	chr1	147131890	-	0.000245573	0.99975437

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Fusion Genomic Features for ARHGEF3-ACP6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGEF3-ACP6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:56916320/chr1:147131890)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ACP6 Q9NPH0
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. {ECO:0000269\|PubMed:10506173, ECO:0000269\|PubMed:23807634}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARHGEF3

chr3:56916319

chr1:147131890

ENST00000296315

122_304

527.0

Domain

Hgene

ARHGEF3

chr3:56916319

chr1:147131890

ENST00000296315

291_449

527.0

Domain

Hgene

ARHGEF3

chr3:56916319

chr1:147131890

ENST00000338458

122_304

559.0

Domain

Hgene

ARHGEF3

chr3:56916319

chr1:147131890

ENST00000338458

291_449

559.0

Domain

Hgene

ARHGEF3

chr3:56916319

chr1:147131890

ENST00000413728

122_304

533.0

Domain

Hgene

ARHGEF3

chr3:56916319

chr1:147131890

ENST00000413728

291_449

533.0

Domain

Hgene

ARHGEF3

chr3:56916320

chr1:147131890

ENST00000296315

122_304

527.0

Domain

Hgene

ARHGEF3

chr3:56916320

chr1:147131890

ENST00000296315

291_449

527.0

Domain

Hgene

ARHGEF3

chr3:56916320

chr1:147131890

ENST00000338458

122_304

559.0

Domain

Hgene

ARHGEF3

chr3:56916320

chr1:147131890

ENST00000338458

291_449

559.0

Domain

Hgene

ARHGEF3

chr3:56916320

chr1:147131890

ENST00000413728

122_304

533.0

Domain

Hgene

ARHGEF3

chr3:56916320

chr1:147131890

ENST00000413728

291_449

533.0

Domain

Tgene

ACP6

chr3:56916319

chr1:147131890

ENST00000369238

58_168

429.0

Region

Substrate binding

Tgene

ACP6

chr3:56916319

chr1:147131890

ENST00000392988

58_168

272.0

Region

Substrate binding

Tgene

ACP6

chr3:56916320

chr1:147131890

ENST00000369238

58_168

429.0

Region

Substrate binding

Tgene

ACP6

chr3:56916320

chr1:147131890

ENST00000392988

58_168

272.0

Region

Substrate binding

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Fusion Gene Sequence for ARHGEF3-ACP6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>6308_6308_1_ARHGEF3-ACP6_ARHGEF3_chr3_56916319_ENST00000338458_ACP6_chr1_147131890_ENST00000369238_length(transcript)=6561nt_BP=302nt
AGCCCAGGGGAGCCGCCGCCGCAGCCGCCGCCGCCGCGGTGAGTTTTCCAGCCTGGAGAGGCCGAACCAGCGCGGGGGTCGAGGAGACCT
GAGCCTGCCATACTGAGTCTATGGACAGTTCCACAGCAATGAATCAATGCAGCTGTAGAGGAATGGAAGAAAACAAGGAAAGGCCTAAAC
GGCAGCGGCAAAACAACTTTCCCATGTTTCCCTCTCCTAAAGCCTGGAATTTCAGAGGGCGAAAACGGAAACAGAGCACCCAAGATGAAG
ATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCAGTTTGATTACACAG
TCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGGCATGTTTGCTGGGC
AGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCCCTTTCTTTCACCAA
CCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGCTGGGCTTTTCCAGT
GTCAGAAAGAAGGACCCATCATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTGCTGGAGCCTGAGGC
AGAGAACCAGAGGCCGGAGGCAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAGGATGGGCATTGACA
GTAGTGATAAAGTGGACTTCTTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCCCATGCTGAAGAGAT
TTGCAAGGATGATCGAACAGAGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCAGATGGCAGTAGGCC
CATTCCTCCACATCCTAGAGAGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCTGTATCTCTATGCGG
CTCATGATGTGACCTTCATACCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGACCTGACCATGGAAC
TTTACCAGCACCTGGAATCTAAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTGCCCTGATGGGCTCT
GCCCGCTGGACATGTTCTTGAATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCAAACTCAGGTGATGG
AAGTTGGAAATGAAGAGTAACTGATTTATAAAAGCAGGATGTGTTGATTTTAAAATAAAGTGCCTTTATACAATGCCTCCTGCTTTGTGT
GTTTGGGAAGAGGAGAGAGCAAGGGGTAATGTACTTTAATATAATGTAAGGATATTTCCTTTCTGTGGGTTTACTAAGATTTCTTCCTGA
ACGGAAAAGGGGTATAATATTGAGACCAAAAGGATATTTCTCTATTTTGTGAGTTGGTTTCTAAGGTTAGAAGCATCTTTGTGTGACACG
GGCTGGGGACATCATGACCCTGTAGAATTGTGTCGGTTTTGGACTTTAGTTCTTTTCTCCTATATTAATTTCACATGTATTGAGCTACCT
ACTAAGTAGTGATCATTATAAAGGTGAAAACACTCTGCCCTCAAGTTGTTGCAGTCCAGTGGGAGAGGCAGCCGAGTAAATCAGTGATAC
AGTGCTGTATGTTTTATGCTGTAATAGGTATTTGAGGGGCTATTTGGGTATAGAGAAGAAACTTCCTGCTCACATGGCAGGGGATGTGGG
GAACAGTCAAGGAAGGCTTCTGAAAAAGTCCTGGCCTGATCTGAGTAGAGAAAGGTGGGTAGGAGTTAACCAGGAAAGCAAGGATGAAAG
CGTGTTGCGTTTAGATAAAGGATAGGCTTCAAGGTCAGGGAACGTTGCTGGGTGGTGAGATGGAACCCTGATGTGGAGGCTCAGCAGGAA
GAAGCAGGAAGGACACTGGGCCCCTGGTGGTTTTAGTTCCAGAAACAAATGTGGGCCCCAGGGCTCTGCAATGGTAAGGCTGGAACTACT
CAACATAAGAGCTCCACCTTTAACTGTGCCCCCTAAGAGTACCTGATGATCCCCCTATCTCCTTGTCAATGTTGCTGTTCTTCTCCAGAA
TCTATTTCAACCCTTCTCTGATTTCAAACCACCAGTCCCTTTACCTCTCAGAGAAAACAGCAACCACAAAAGCCTCTCCACTTCCTACTA
TCTTAATATTGACAACTTCCAGATCAGGGAGCTGAGATATCTCAAGCTCAGGTTTCTCTTCTGAGCTTCAGACGCTTTTATCCACTTGGA
TTTCACTGGCACAAAACTTTCCATGTTAGAATCAAACCCCCCTCCTCCCAGACCTGCTTCTCCCACACACTTCCCTATCTGAATGAAAGA
CACCTCCACTCTCCACCCAGTTGCCAAATCAGAAATCTGTCTTTGTTTTCTTTGTCTCACATTTTCCTATGTCTAATCAGTTAAGTTTTA
TCAATACTACCTGTTTATTTCTTTAATCTATTCACATATCTTTATCCTCAATCTTCAGCATCCCCTTCCCATCCTCAGTCTGCTGGTTAC
TGTATTTCCTATTTTACTAAGAATCTAAAAGAGATCAGAAGAAAACTTCCACATCCCCCAACACCCAACCACCAAATCTGCTAACCCAGT
TGCATTGGTGCTTTTATAGCCTTCCTTCCTCCCTCTTACTAAGAATGAACCAACACTATTCCTATCAAAGCCCAACCCTCTAGCTTTACA
TTGACTCCTAGTGTCTTTTTTCTGGATTGTCAATTTTTTTCCTGACCAATTATTCTATTAGCAATACAAATATGCTGTAAAATCTCTTAA
ACTTTTTTCTCTGCATCTTTGAACTGCTGTTCTCTTTTCCTTCTCCCCTTCATAGCAGAACTCCTCAAAAGAGTTGCTACCTCTAATTCT
TCCCTTCCAGTTCTCTCATGAACCAGCTACAATTAAGTATTCACCCCCACCACTCCATGGAAACTGCTCTTGTCAAAATCATCAATAGCC
TTTGTGTGGTGAATCCAATAGCCAGTTTTCATTCTTCTTACTAAGCTTCTCATCAGTATTCCTAGACTATTTCCTTCACTGGCTTCGACA
AATGCTTTCTTGGTTTTCCTCCAATTTCTCGACTTTGTTCCTGCTGAATCTACCTTTTTCTAATCCGTAAGTGTTGGGGTGTCCCAGGGC
TTACTCCTTGGACCTTTTTTCCACCTTTTCCCCTACACTCACCCACTAGGTGATCTCAAGAATTTCCAGTTTGAGGCCGGGCGCGGTGGC
TCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGCCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAA
ACCCTGTCTCCACTAAACCTGCCTCTACTAAAAATACAAAAATTATTATATTTTTATAAAATTATTATAATTTTATAAAATTATTATATT
TATGGAGTACAATGTGATGTAATCCCAGCTACTCGGAAGGCTGTATGTGTCTATTTATGGAGTACAATGTGCCTGTAATCCCAGCTACTT
GGGAGGCTGAGGCAGGAGAATCACTTCAACCTAGGAGGCAGAGGTTGTGCTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACA
AGAGAGAAATAACATCTCAAAAAAAAAAAAAAAGAATTTCCAGTTTTAAATATTTACACAATGTCTCCTAAATTTATACCTTCAACCTAG
ACCTTTCCCTGTGAATCCCAGTCTCATTTCCAACAGTCTAATCAATGTCTCTATTTGGATGTTTAAGATATACAATAGGTATCAAACTTC
CCATTGTCCACAATAAACTCTCAATTTCCGTGCCTTTTCAAACTTACTCCTTCCACAGGCTTTCCCATCTAGGTAAATGACACCACCATT
CACCCTGTTGCTTTGGCCAAGAACTTTAGAACTGCCCTTGACTCCCCTCTTTTTCTCATATCCTACCTCTACTACATCAGTAACTCCTGT
TGTATCTCTCTTCAAACTATATCCAGAATTGACCATGTCCCAATACTTCCATTGCTACTGTCTTAGTCCCAGTGTCATCTTTTACCTGGA
TTATTGTAAAGGCCTCGTAACTAGTCTTCCTGTTTCTGCCCTTCCCTTCTCTGCCCATCTATTCTCAACACAGTGTTGCTTTTAAAACAA
AGTAAGATCGTGCCACTCTTCTGCTCTAAATTCCCCATTGGTTTCTCATCTCAAACTAAGGGCCAGTCATAATGCCCTCACGGTCCTATG
ACATCTCACTGCACCCCAGCCATACTCGCCATCTTACCATTCTTCTTCTTTTTTGTAATAAAAACTTTTTACTTTCTTTTTAGTTGACAG
ATAATAATTGCGTATATTTATGGAGTACAATGTGATGTTTTGATATATGTATGCATGAGGGAATGATTAAATCAAGCTAATTAACATATT
CATCACTTCATCTACTCATCACTTTCTTGTGGTGAAAATGTTTCAGATATACTCTTTAGTAGTTTTCAGGTGTACAGTCGCTGTGGTTTG
AGTGCTTTTGTCTTCTCTAAATTTGATGTTGACACTTAGTGCCCAGTACAATGTTACTGGGAGGTGGAGCCTAATGGGGATGTTTAATGG
ATTAATGCCATTATAAAAAGGGCTTGCAGGAATGGGTTCCTTCTCTTTTGCTTTTCTGCCATATGATGACAAAGTGTTCCTCCTCTCTGG
AGGATGCAGCAACAGGCACCATCTTTGAAGCAGAGAGACCAGGCCCTAACCTTCTGGTGCCTTGATCTTGGACTTCTCAGCTTCCAGAAC
TGTGAGATAATAAATTTCTGTTCATTACAAATTACCCCATCTGTGGTATTCTGTTATAGCAACACAAAATGGACTAAGACAACAGTATAC
TGTTATGAACTATGGTCACCATGCTGTGCACTAGATCACAAAAACTTATTTCTACTGTTTAACTGAAACTTTGTACATTTTGACTAACAT
CTCCCTTTTTCCCATCATCCCATCCCATTCTTACTATCGTTGAAGATGGAGTATGCCAAGTAGTCCTGAGCCATGTCCTCACCTCGGGGT
GAGCACCTGTTGTTCCTGTGCCTGGAATGCTCTCCTAGACATTTGCGTGGCTAGCTCCCTCTTTTCATTCAGATCTCAGCTCATTGTCAT
CTCAGAGAGGCCCTCCTTGCCCTCCTTCTACCTCCTGCCTTAGGTATACTCTGCCACCTTCTGTCATGGGCTGAATTGTGTCCCCCCTAA
ATCCATATGTTGACATCTTAACCCCTAGTACAGTAAGTCCTCACTTGATGCTATCAATAGGCTCTTGGAAATGTCGGCTTTCAGTGAAAG
GACATATAGCAGGTCCTTGAATAACATTGTGTTTTGTTCAACATCGTTGCCTTGTAACACTGATGAGCAAAACAGTTGGTTCTCTAATAT
GTTGTTTTACTTAAAGCTACAGTTTCCAAGAACCTATCAATGATGTTGAGGACTGAATGTACCTCAGGTGTAATGTATTTGGAGATAGGG
CCTTTTAAGAGGTAAAGTAAATGAGGTCATATGGGTAGGCTGTAATCCAATATGACTGGAATCCTTATAAGAAGAGGAAATGAGGACACA
GACACAGAGGGAAGATGACTATCTGCAAGTCAAGGAGAGAGGCCTCAGAAGAAACCAATGCTGCTGACACCACGATCTTGGACTTCTAGC
CTCTAGCACTGTGAGGAAATAAATTTCTGTTGTTTAAGCCACCTAGTCTGTGATACTTTGCTACGGCAGGCCCTAGCAAATGAATACACT
TGTCTTGTCTTTCCCCCGCCCTGTGATATTTATCAGTGCCGGATATTACATATTTGTGTATCTATATGCTTATTTCCCTGACTAAAATGG
AAGCTCCATGAAGGCAGATTTCCTCTTGTTCACTGATGTGTCCCCAGCACCTGGAATAGTGCCTAGTGCATGCCAGTGCTCAGACACTTG
GACATTTGAATGACATATCCCCTCTGTCACTTCTCTCCGGGGCCCAAGGCCACCCTCCTAGGTTACCACAGTGGCTTCCTAATGGGCCAT
ACCCTCACTTGCTTTCCATCACCCCCTGAGACCTGGCCCCTGCATACCTCTCCAGCTTCACCCCTCACATATCTCCCTAGCCAGACCTAT
AGTATGTTTTAAAAAAAAAGGAAATCGCACTCCTCTGGCCTCTTTACCTTGGCACACATTTTTCCATCACCTGACCCCTGACCCACACTC
CCTTTTCCTGTGTAATCCAATTATCTCTAGGCCTCCCGTGTTTCTGTTTGTCCTTCAATAGAAGGTTGTTTGTCTTGTCTTTTATTGTAT

>6308_6308_1_ARHGEF3-ACP6_ARHGEF3_chr3_56916319_ENST00000338458_ACP6_chr1_147131890_ENST00000369238_length(amino acids)=419AA_BP=64
MDSSTAMNQCSCRGMEENKERPKRQRQNNFPMFPSPKAWNFRGRKRKQSTQDEDAVSLCSLDISVEWNPQLLEVPPQTQFDYTVTNLAGG
PKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPI
IIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQ
RAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAVDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLES

--------------------------------------------------------------
>6308_6308_2_ARHGEF3-ACP6_ARHGEF3_chr3_56916319_ENST00000496106_ACP6_chr1_147131890_ENST00000369238_length(transcript)=6485nt_BP=226nt
ATGCAGCCCAAGTGGCGGGGAGGAGTTCCTTCAGGGAAACTATGCTCAGCCCTGTTCAGAGAATCCTGTGCACAGGGCTCCACTGCAGTT
AGGAGCCGGTGAGTCCGGGTGGATGAGGTCAGAGCGCCCCATGGTGTGGTGCTGCCTCTTTGTCCGTTCGCAGCGAAAACGGAAACAGAG
CACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCA
GTTTGATTACACAGTCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGG
CATGTTTGCTGGGCAGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCC
CTTTCTTTCACCAACCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGC
TGGGCTTTTCCAGTGTCAGAAAGAAGGACCCATCATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTG
CTGGAGCCTGAGGCAGAGAACCAGAGGCCGGAGGCAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAG
GATGGGCATTGACAGTAGTGATAAAGTGGACTTCTTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCC
CATGCTGAAGAGATTTGCAAGGATGATCGAACAGAGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCA
GATGGCAGTAGGCCCATTCCTCCACATCCTAGAGAGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCT
GTATCTCTATGCGGCTCATGATGTGACCTTCATACCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGA
CCTGACCATGGAACTTTACCAGCACCTGGAATCTAAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTG
CCCTGATGGGCTCTGCCCGCTGGACATGTTCTTGAATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCA
AACTCAGGTGATGGAAGTTGGAAATGAAGAGTAACTGATTTATAAAAGCAGGATGTGTTGATTTTAAAATAAAGTGCCTTTATACAATGC
CTCCTGCTTTGTGTGTTTGGGAAGAGGAGAGAGCAAGGGGTAATGTACTTTAATATAATGTAAGGATATTTCCTTTCTGTGGGTTTACTA
AGATTTCTTCCTGAACGGAAAAGGGGTATAATATTGAGACCAAAAGGATATTTCTCTATTTTGTGAGTTGGTTTCTAAGGTTAGAAGCAT
CTTTGTGTGACACGGGCTGGGGACATCATGACCCTGTAGAATTGTGTCGGTTTTGGACTTTAGTTCTTTTCTCCTATATTAATTTCACAT
GTATTGAGCTACCTACTAAGTAGTGATCATTATAAAGGTGAAAACACTCTGCCCTCAAGTTGTTGCAGTCCAGTGGGAGAGGCAGCCGAG
TAAATCAGTGATACAGTGCTGTATGTTTTATGCTGTAATAGGTATTTGAGGGGCTATTTGGGTATAGAGAAGAAACTTCCTGCTCACATG
GCAGGGGATGTGGGGAACAGTCAAGGAAGGCTTCTGAAAAAGTCCTGGCCTGATCTGAGTAGAGAAAGGTGGGTAGGAGTTAACCAGGAA
AGCAAGGATGAAAGCGTGTTGCGTTTAGATAAAGGATAGGCTTCAAGGTCAGGGAACGTTGCTGGGTGGTGAGATGGAACCCTGATGTGG
AGGCTCAGCAGGAAGAAGCAGGAAGGACACTGGGCCCCTGGTGGTTTTAGTTCCAGAAACAAATGTGGGCCCCAGGGCTCTGCAATGGTA
AGGCTGGAACTACTCAACATAAGAGCTCCACCTTTAACTGTGCCCCCTAAGAGTACCTGATGATCCCCCTATCTCCTTGTCAATGTTGCT
GTTCTTCTCCAGAATCTATTTCAACCCTTCTCTGATTTCAAACCACCAGTCCCTTTACCTCTCAGAGAAAACAGCAACCACAAAAGCCTC
TCCACTTCCTACTATCTTAATATTGACAACTTCCAGATCAGGGAGCTGAGATATCTCAAGCTCAGGTTTCTCTTCTGAGCTTCAGACGCT
TTTATCCACTTGGATTTCACTGGCACAAAACTTTCCATGTTAGAATCAAACCCCCCTCCTCCCAGACCTGCTTCTCCCACACACTTCCCT
ATCTGAATGAAAGACACCTCCACTCTCCACCCAGTTGCCAAATCAGAAATCTGTCTTTGTTTTCTTTGTCTCACATTTTCCTATGTCTAA
TCAGTTAAGTTTTATCAATACTACCTGTTTATTTCTTTAATCTATTCACATATCTTTATCCTCAATCTTCAGCATCCCCTTCCCATCCTC
AGTCTGCTGGTTACTGTATTTCCTATTTTACTAAGAATCTAAAAGAGATCAGAAGAAAACTTCCACATCCCCCAACACCCAACCACCAAA
TCTGCTAACCCAGTTGCATTGGTGCTTTTATAGCCTTCCTTCCTCCCTCTTACTAAGAATGAACCAACACTATTCCTATCAAAGCCCAAC
CCTCTAGCTTTACATTGACTCCTAGTGTCTTTTTTCTGGATTGTCAATTTTTTTCCTGACCAATTATTCTATTAGCAATACAAATATGCT
GTAAAATCTCTTAAACTTTTTTCTCTGCATCTTTGAACTGCTGTTCTCTTTTCCTTCTCCCCTTCATAGCAGAACTCCTCAAAAGAGTTG
CTACCTCTAATTCTTCCCTTCCAGTTCTCTCATGAACCAGCTACAATTAAGTATTCACCCCCACCACTCCATGGAAACTGCTCTTGTCAA
AATCATCAATAGCCTTTGTGTGGTGAATCCAATAGCCAGTTTTCATTCTTCTTACTAAGCTTCTCATCAGTATTCCTAGACTATTTCCTT
CACTGGCTTCGACAAATGCTTTCTTGGTTTTCCTCCAATTTCTCGACTTTGTTCCTGCTGAATCTACCTTTTTCTAATCCGTAAGTGTTG
GGGTGTCCCAGGGCTTACTCCTTGGACCTTTTTTCCACCTTTTCCCCTACACTCACCCACTAGGTGATCTCAAGAATTTCCAGTTTGAGG
CCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGCCAGGAGTTCGAGACCAGCCTG
GCCAACATGGCAAAACCCTGTCTCCACTAAACCTGCCTCTACTAAAAATACAAAAATTATTATATTTTTATAAAATTATTATAATTTTAT
AAAATTATTATATTTATGGAGTACAATGTGATGTAATCCCAGCTACTCGGAAGGCTGTATGTGTCTATTTATGGAGTACAATGTGCCTGT
AATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTCAACCTAGGAGGCAGAGGTTGTGCTGAGCCAAGATCGTGCCATTGCACTC
CAGCCTGGGCAACAAGAGAGAAATAACATCTCAAAAAAAAAAAAAAAGAATTTCCAGTTTTAAATATTTACACAATGTCTCCTAAATTTA
TACCTTCAACCTAGACCTTTCCCTGTGAATCCCAGTCTCATTTCCAACAGTCTAATCAATGTCTCTATTTGGATGTTTAAGATATACAAT
AGGTATCAAACTTCCCATTGTCCACAATAAACTCTCAATTTCCGTGCCTTTTCAAACTTACTCCTTCCACAGGCTTTCCCATCTAGGTAA
ATGACACCACCATTCACCCTGTTGCTTTGGCCAAGAACTTTAGAACTGCCCTTGACTCCCCTCTTTTTCTCATATCCTACCTCTACTACA
TCAGTAACTCCTGTTGTATCTCTCTTCAAACTATATCCAGAATTGACCATGTCCCAATACTTCCATTGCTACTGTCTTAGTCCCAGTGTC
ATCTTTTACCTGGATTATTGTAAAGGCCTCGTAACTAGTCTTCCTGTTTCTGCCCTTCCCTTCTCTGCCCATCTATTCTCAACACAGTGT
TGCTTTTAAAACAAAGTAAGATCGTGCCACTCTTCTGCTCTAAATTCCCCATTGGTTTCTCATCTCAAACTAAGGGCCAGTCATAATGCC
CTCACGGTCCTATGACATCTCACTGCACCCCAGCCATACTCGCCATCTTACCATTCTTCTTCTTTTTTGTAATAAAAACTTTTTACTTTC
TTTTTAGTTGACAGATAATAATTGCGTATATTTATGGAGTACAATGTGATGTTTTGATATATGTATGCATGAGGGAATGATTAAATCAAG
CTAATTAACATATTCATCACTTCATCTACTCATCACTTTCTTGTGGTGAAAATGTTTCAGATATACTCTTTAGTAGTTTTCAGGTGTACA
GTCGCTGTGGTTTGAGTGCTTTTGTCTTCTCTAAATTTGATGTTGACACTTAGTGCCCAGTACAATGTTACTGGGAGGTGGAGCCTAATG
GGGATGTTTAATGGATTAATGCCATTATAAAAAGGGCTTGCAGGAATGGGTTCCTTCTCTTTTGCTTTTCTGCCATATGATGACAAAGTG
TTCCTCCTCTCTGGAGGATGCAGCAACAGGCACCATCTTTGAAGCAGAGAGACCAGGCCCTAACCTTCTGGTGCCTTGATCTTGGACTTC
TCAGCTTCCAGAACTGTGAGATAATAAATTTCTGTTCATTACAAATTACCCCATCTGTGGTATTCTGTTATAGCAACACAAAATGGACTA
AGACAACAGTATACTGTTATGAACTATGGTCACCATGCTGTGCACTAGATCACAAAAACTTATTTCTACTGTTTAACTGAAACTTTGTAC
ATTTTGACTAACATCTCCCTTTTTCCCATCATCCCATCCCATTCTTACTATCGTTGAAGATGGAGTATGCCAAGTAGTCCTGAGCCATGT
CCTCACCTCGGGGTGAGCACCTGTTGTTCCTGTGCCTGGAATGCTCTCCTAGACATTTGCGTGGCTAGCTCCCTCTTTTCATTCAGATCT
CAGCTCATTGTCATCTCAGAGAGGCCCTCCTTGCCCTCCTTCTACCTCCTGCCTTAGGTATACTCTGCCACCTTCTGTCATGGGCTGAAT
TGTGTCCCCCCTAAATCCATATGTTGACATCTTAACCCCTAGTACAGTAAGTCCTCACTTGATGCTATCAATAGGCTCTTGGAAATGTCG
GCTTTCAGTGAAAGGACATATAGCAGGTCCTTGAATAACATTGTGTTTTGTTCAACATCGTTGCCTTGTAACACTGATGAGCAAAACAGT
TGGTTCTCTAATATGTTGTTTTACTTAAAGCTACAGTTTCCAAGAACCTATCAATGATGTTGAGGACTGAATGTACCTCAGGTGTAATGT
ATTTGGAGATAGGGCCTTTTAAGAGGTAAAGTAAATGAGGTCATATGGGTAGGCTGTAATCCAATATGACTGGAATCCTTATAAGAAGAG
GAAATGAGGACACAGACACAGAGGGAAGATGACTATCTGCAAGTCAAGGAGAGAGGCCTCAGAAGAAACCAATGCTGCTGACACCACGAT
CTTGGACTTCTAGCCTCTAGCACTGTGAGGAAATAAATTTCTGTTGTTTAAGCCACCTAGTCTGTGATACTTTGCTACGGCAGGCCCTAG
CAAATGAATACACTTGTCTTGTCTTTCCCCCGCCCTGTGATATTTATCAGTGCCGGATATTACATATTTGTGTATCTATATGCTTATTTC
CCTGACTAAAATGGAAGCTCCATGAAGGCAGATTTCCTCTTGTTCACTGATGTGTCCCCAGCACCTGGAATAGTGCCTAGTGCATGCCAG
TGCTCAGACACTTGGACATTTGAATGACATATCCCCTCTGTCACTTCTCTCCGGGGCCCAAGGCCACCCTCCTAGGTTACCACAGTGGCT
TCCTAATGGGCCATACCCTCACTTGCTTTCCATCACCCCCTGAGACCTGGCCCCTGCATACCTCTCCAGCTTCACCCCTCACATATCTCC
CTAGCCAGACCTATAGTATGTTTTAAAAAAAAAGGAAATCGCACTCCTCTGGCCTCTTTACCTTGGCACACATTTTTCCATCACCTGACC
CCTGACCCACACTCCCTTTTCCTGTGTAATCCAATTATCTCTAGGCCTCCCGTGTTTCTGTTTGTCCTTCAATAGAAGGTTGTTTGTCTT
GTCTTTTATTGTATTTCTAGAACCAAGTGCAGAGACTGTACAAAGTGGACCTCAGCAAAGATTTACCGAATGAATAAATGAGTTCAGAAC

>6308_6308_2_ARHGEF3-ACP6_ARHGEF3_chr3_56916319_ENST00000496106_ACP6_chr1_147131890_ENST00000369238_length(amino acids)=403AA_BP=48
MQLGAGESGWMRSERPMVWCCLFVRSQRKRKQSTQDEDAVSLCSLDISVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTL
KGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNY
QSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDRE
SLQMAVGPFLHILESNLLKAVDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVP

--------------------------------------------------------------
>6308_6308_3_ARHGEF3-ACP6_ARHGEF3_chr3_56916320_ENST00000338458_ACP6_chr1_147131890_ENST00000369238_length(transcript)=6561nt_BP=302nt
AGCCCAGGGGAGCCGCCGCCGCAGCCGCCGCCGCCGCGGTGAGTTTTCCAGCCTGGAGAGGCCGAACCAGCGCGGGGGTCGAGGAGACCT
GAGCCTGCCATACTGAGTCTATGGACAGTTCCACAGCAATGAATCAATGCAGCTGTAGAGGAATGGAAGAAAACAAGGAAAGGCCTAAAC
GGCAGCGGCAAAACAACTTTCCCATGTTTCCCTCTCCTAAAGCCTGGAATTTCAGAGGGCGAAAACGGAAACAGAGCACCCAAGATGAAG
ATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCAGTTTGATTACACAG
TCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGGCATGTTTGCTGGGC
AGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCCCTTTCTTTCACCAA
CCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGCTGGGCTTTTCCAGT
GTCAGAAAGAAGGACCCATCATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTGCTGGAGCCTGAGGC
AGAGAACCAGAGGCCGGAGGCAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAGGATGGGCATTGACA
GTAGTGATAAAGTGGACTTCTTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCCCATGCTGAAGAGAT
TTGCAAGGATGATCGAACAGAGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCAGATGGCAGTAGGCC
CATTCCTCCACATCCTAGAGAGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCTGTATCTCTATGCGG
CTCATGATGTGACCTTCATACCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGACCTGACCATGGAAC
TTTACCAGCACCTGGAATCTAAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTGCCCTGATGGGCTCT
GCCCGCTGGACATGTTCTTGAATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCAAACTCAGGTGATGG
AAGTTGGAAATGAAGAGTAACTGATTTATAAAAGCAGGATGTGTTGATTTTAAAATAAAGTGCCTTTATACAATGCCTCCTGCTTTGTGT
GTTTGGGAAGAGGAGAGAGCAAGGGGTAATGTACTTTAATATAATGTAAGGATATTTCCTTTCTGTGGGTTTACTAAGATTTCTTCCTGA
ACGGAAAAGGGGTATAATATTGAGACCAAAAGGATATTTCTCTATTTTGTGAGTTGGTTTCTAAGGTTAGAAGCATCTTTGTGTGACACG
GGCTGGGGACATCATGACCCTGTAGAATTGTGTCGGTTTTGGACTTTAGTTCTTTTCTCCTATATTAATTTCACATGTATTGAGCTACCT
ACTAAGTAGTGATCATTATAAAGGTGAAAACACTCTGCCCTCAAGTTGTTGCAGTCCAGTGGGAGAGGCAGCCGAGTAAATCAGTGATAC
AGTGCTGTATGTTTTATGCTGTAATAGGTATTTGAGGGGCTATTTGGGTATAGAGAAGAAACTTCCTGCTCACATGGCAGGGGATGTGGG
GAACAGTCAAGGAAGGCTTCTGAAAAAGTCCTGGCCTGATCTGAGTAGAGAAAGGTGGGTAGGAGTTAACCAGGAAAGCAAGGATGAAAG
CGTGTTGCGTTTAGATAAAGGATAGGCTTCAAGGTCAGGGAACGTTGCTGGGTGGTGAGATGGAACCCTGATGTGGAGGCTCAGCAGGAA
GAAGCAGGAAGGACACTGGGCCCCTGGTGGTTTTAGTTCCAGAAACAAATGTGGGCCCCAGGGCTCTGCAATGGTAAGGCTGGAACTACT
CAACATAAGAGCTCCACCTTTAACTGTGCCCCCTAAGAGTACCTGATGATCCCCCTATCTCCTTGTCAATGTTGCTGTTCTTCTCCAGAA
TCTATTTCAACCCTTCTCTGATTTCAAACCACCAGTCCCTTTACCTCTCAGAGAAAACAGCAACCACAAAAGCCTCTCCACTTCCTACTA
TCTTAATATTGACAACTTCCAGATCAGGGAGCTGAGATATCTCAAGCTCAGGTTTCTCTTCTGAGCTTCAGACGCTTTTATCCACTTGGA
TTTCACTGGCACAAAACTTTCCATGTTAGAATCAAACCCCCCTCCTCCCAGACCTGCTTCTCCCACACACTTCCCTATCTGAATGAAAGA
CACCTCCACTCTCCACCCAGTTGCCAAATCAGAAATCTGTCTTTGTTTTCTTTGTCTCACATTTTCCTATGTCTAATCAGTTAAGTTTTA
TCAATACTACCTGTTTATTTCTTTAATCTATTCACATATCTTTATCCTCAATCTTCAGCATCCCCTTCCCATCCTCAGTCTGCTGGTTAC
TGTATTTCCTATTTTACTAAGAATCTAAAAGAGATCAGAAGAAAACTTCCACATCCCCCAACACCCAACCACCAAATCTGCTAACCCAGT
TGCATTGGTGCTTTTATAGCCTTCCTTCCTCCCTCTTACTAAGAATGAACCAACACTATTCCTATCAAAGCCCAACCCTCTAGCTTTACA
TTGACTCCTAGTGTCTTTTTTCTGGATTGTCAATTTTTTTCCTGACCAATTATTCTATTAGCAATACAAATATGCTGTAAAATCTCTTAA
ACTTTTTTCTCTGCATCTTTGAACTGCTGTTCTCTTTTCCTTCTCCCCTTCATAGCAGAACTCCTCAAAAGAGTTGCTACCTCTAATTCT
TCCCTTCCAGTTCTCTCATGAACCAGCTACAATTAAGTATTCACCCCCACCACTCCATGGAAACTGCTCTTGTCAAAATCATCAATAGCC
TTTGTGTGGTGAATCCAATAGCCAGTTTTCATTCTTCTTACTAAGCTTCTCATCAGTATTCCTAGACTATTTCCTTCACTGGCTTCGACA
AATGCTTTCTTGGTTTTCCTCCAATTTCTCGACTTTGTTCCTGCTGAATCTACCTTTTTCTAATCCGTAAGTGTTGGGGTGTCCCAGGGC
TTACTCCTTGGACCTTTTTTCCACCTTTTCCCCTACACTCACCCACTAGGTGATCTCAAGAATTTCCAGTTTGAGGCCGGGCGCGGTGGC
TCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGCCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAA
ACCCTGTCTCCACTAAACCTGCCTCTACTAAAAATACAAAAATTATTATATTTTTATAAAATTATTATAATTTTATAAAATTATTATATT
TATGGAGTACAATGTGATGTAATCCCAGCTACTCGGAAGGCTGTATGTGTCTATTTATGGAGTACAATGTGCCTGTAATCCCAGCTACTT
GGGAGGCTGAGGCAGGAGAATCACTTCAACCTAGGAGGCAGAGGTTGTGCTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACA
AGAGAGAAATAACATCTCAAAAAAAAAAAAAAAGAATTTCCAGTTTTAAATATTTACACAATGTCTCCTAAATTTATACCTTCAACCTAG
ACCTTTCCCTGTGAATCCCAGTCTCATTTCCAACAGTCTAATCAATGTCTCTATTTGGATGTTTAAGATATACAATAGGTATCAAACTTC
CCATTGTCCACAATAAACTCTCAATTTCCGTGCCTTTTCAAACTTACTCCTTCCACAGGCTTTCCCATCTAGGTAAATGACACCACCATT
CACCCTGTTGCTTTGGCCAAGAACTTTAGAACTGCCCTTGACTCCCCTCTTTTTCTCATATCCTACCTCTACTACATCAGTAACTCCTGT
TGTATCTCTCTTCAAACTATATCCAGAATTGACCATGTCCCAATACTTCCATTGCTACTGTCTTAGTCCCAGTGTCATCTTTTACCTGGA
TTATTGTAAAGGCCTCGTAACTAGTCTTCCTGTTTCTGCCCTTCCCTTCTCTGCCCATCTATTCTCAACACAGTGTTGCTTTTAAAACAA
AGTAAGATCGTGCCACTCTTCTGCTCTAAATTCCCCATTGGTTTCTCATCTCAAACTAAGGGCCAGTCATAATGCCCTCACGGTCCTATG
ACATCTCACTGCACCCCAGCCATACTCGCCATCTTACCATTCTTCTTCTTTTTTGTAATAAAAACTTTTTACTTTCTTTTTAGTTGACAG
ATAATAATTGCGTATATTTATGGAGTACAATGTGATGTTTTGATATATGTATGCATGAGGGAATGATTAAATCAAGCTAATTAACATATT
CATCACTTCATCTACTCATCACTTTCTTGTGGTGAAAATGTTTCAGATATACTCTTTAGTAGTTTTCAGGTGTACAGTCGCTGTGGTTTG
AGTGCTTTTGTCTTCTCTAAATTTGATGTTGACACTTAGTGCCCAGTACAATGTTACTGGGAGGTGGAGCCTAATGGGGATGTTTAATGG
ATTAATGCCATTATAAAAAGGGCTTGCAGGAATGGGTTCCTTCTCTTTTGCTTTTCTGCCATATGATGACAAAGTGTTCCTCCTCTCTGG
AGGATGCAGCAACAGGCACCATCTTTGAAGCAGAGAGACCAGGCCCTAACCTTCTGGTGCCTTGATCTTGGACTTCTCAGCTTCCAGAAC
TGTGAGATAATAAATTTCTGTTCATTACAAATTACCCCATCTGTGGTATTCTGTTATAGCAACACAAAATGGACTAAGACAACAGTATAC
TGTTATGAACTATGGTCACCATGCTGTGCACTAGATCACAAAAACTTATTTCTACTGTTTAACTGAAACTTTGTACATTTTGACTAACAT
CTCCCTTTTTCCCATCATCCCATCCCATTCTTACTATCGTTGAAGATGGAGTATGCCAAGTAGTCCTGAGCCATGTCCTCACCTCGGGGT
GAGCACCTGTTGTTCCTGTGCCTGGAATGCTCTCCTAGACATTTGCGTGGCTAGCTCCCTCTTTTCATTCAGATCTCAGCTCATTGTCAT
CTCAGAGAGGCCCTCCTTGCCCTCCTTCTACCTCCTGCCTTAGGTATACTCTGCCACCTTCTGTCATGGGCTGAATTGTGTCCCCCCTAA
ATCCATATGTTGACATCTTAACCCCTAGTACAGTAAGTCCTCACTTGATGCTATCAATAGGCTCTTGGAAATGTCGGCTTTCAGTGAAAG
GACATATAGCAGGTCCTTGAATAACATTGTGTTTTGTTCAACATCGTTGCCTTGTAACACTGATGAGCAAAACAGTTGGTTCTCTAATAT
GTTGTTTTACTTAAAGCTACAGTTTCCAAGAACCTATCAATGATGTTGAGGACTGAATGTACCTCAGGTGTAATGTATTTGGAGATAGGG
CCTTTTAAGAGGTAAAGTAAATGAGGTCATATGGGTAGGCTGTAATCCAATATGACTGGAATCCTTATAAGAAGAGGAAATGAGGACACA
GACACAGAGGGAAGATGACTATCTGCAAGTCAAGGAGAGAGGCCTCAGAAGAAACCAATGCTGCTGACACCACGATCTTGGACTTCTAGC
CTCTAGCACTGTGAGGAAATAAATTTCTGTTGTTTAAGCCACCTAGTCTGTGATACTTTGCTACGGCAGGCCCTAGCAAATGAATACACT
TGTCTTGTCTTTCCCCCGCCCTGTGATATTTATCAGTGCCGGATATTACATATTTGTGTATCTATATGCTTATTTCCCTGACTAAAATGG
AAGCTCCATGAAGGCAGATTTCCTCTTGTTCACTGATGTGTCCCCAGCACCTGGAATAGTGCCTAGTGCATGCCAGTGCTCAGACACTTG
GACATTTGAATGACATATCCCCTCTGTCACTTCTCTCCGGGGCCCAAGGCCACCCTCCTAGGTTACCACAGTGGCTTCCTAATGGGCCAT
ACCCTCACTTGCTTTCCATCACCCCCTGAGACCTGGCCCCTGCATACCTCTCCAGCTTCACCCCTCACATATCTCCCTAGCCAGACCTAT
AGTATGTTTTAAAAAAAAAGGAAATCGCACTCCTCTGGCCTCTTTACCTTGGCACACATTTTTCCATCACCTGACCCCTGACCCACACTC
CCTTTTCCTGTGTAATCCAATTATCTCTAGGCCTCCCGTGTTTCTGTTTGTCCTTCAATAGAAGGTTGTTTGTCTTGTCTTTTATTGTAT

>6308_6308_3_ARHGEF3-ACP6_ARHGEF3_chr3_56916320_ENST00000338458_ACP6_chr1_147131890_ENST00000369238_length(amino acids)=419AA_BP=64
MDSSTAMNQCSCRGMEENKERPKRQRQNNFPMFPSPKAWNFRGRKRKQSTQDEDAVSLCSLDISVEWNPQLLEVPPQTQFDYTVTNLAGG
PKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPI
IIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQ
RAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAVDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLES

--------------------------------------------------------------
>6308_6308_4_ARHGEF3-ACP6_ARHGEF3_chr3_56916320_ENST00000496106_ACP6_chr1_147131890_ENST00000369238_length(transcript)=6485nt_BP=226nt
ATGCAGCCCAAGTGGCGGGGAGGAGTTCCTTCAGGGAAACTATGCTCAGCCCTGTTCAGAGAATCCTGTGCACAGGGCTCCACTGCAGTT
AGGAGCCGGTGAGTCCGGGTGGATGAGGTCAGAGCGCCCCATGGTGTGGTGCTGCCTCTTTGTCCGTTCGCAGCGAAAACGGAAACAGAG
CACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCA
GTTTGATTACACAGTCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGG
CATGTTTGCTGGGCAGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCC
CTTTCTTTCACCAACCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGC
TGGGCTTTTCCAGTGTCAGAAAGAAGGACCCATCATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTG
CTGGAGCCTGAGGCAGAGAACCAGAGGCCGGAGGCAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAG
GATGGGCATTGACAGTAGTGATAAAGTGGACTTCTTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCC
CATGCTGAAGAGATTTGCAAGGATGATCGAACAGAGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCA
GATGGCAGTAGGCCCATTCCTCCACATCCTAGAGAGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCT
GTATCTCTATGCGGCTCATGATGTGACCTTCATACCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGA
CCTGACCATGGAACTTTACCAGCACCTGGAATCTAAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTG
CCCTGATGGGCTCTGCCCGCTGGACATGTTCTTGAATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCA
AACTCAGGTGATGGAAGTTGGAAATGAAGAGTAACTGATTTATAAAAGCAGGATGTGTTGATTTTAAAATAAAGTGCCTTTATACAATGC
CTCCTGCTTTGTGTGTTTGGGAAGAGGAGAGAGCAAGGGGTAATGTACTTTAATATAATGTAAGGATATTTCCTTTCTGTGGGTTTACTA
AGATTTCTTCCTGAACGGAAAAGGGGTATAATATTGAGACCAAAAGGATATTTCTCTATTTTGTGAGTTGGTTTCTAAGGTTAGAAGCAT
CTTTGTGTGACACGGGCTGGGGACATCATGACCCTGTAGAATTGTGTCGGTTTTGGACTTTAGTTCTTTTCTCCTATATTAATTTCACAT
GTATTGAGCTACCTACTAAGTAGTGATCATTATAAAGGTGAAAACACTCTGCCCTCAAGTTGTTGCAGTCCAGTGGGAGAGGCAGCCGAG
TAAATCAGTGATACAGTGCTGTATGTTTTATGCTGTAATAGGTATTTGAGGGGCTATTTGGGTATAGAGAAGAAACTTCCTGCTCACATG
GCAGGGGATGTGGGGAACAGTCAAGGAAGGCTTCTGAAAAAGTCCTGGCCTGATCTGAGTAGAGAAAGGTGGGTAGGAGTTAACCAGGAA
AGCAAGGATGAAAGCGTGTTGCGTTTAGATAAAGGATAGGCTTCAAGGTCAGGGAACGTTGCTGGGTGGTGAGATGGAACCCTGATGTGG
AGGCTCAGCAGGAAGAAGCAGGAAGGACACTGGGCCCCTGGTGGTTTTAGTTCCAGAAACAAATGTGGGCCCCAGGGCTCTGCAATGGTA
AGGCTGGAACTACTCAACATAAGAGCTCCACCTTTAACTGTGCCCCCTAAGAGTACCTGATGATCCCCCTATCTCCTTGTCAATGTTGCT
GTTCTTCTCCAGAATCTATTTCAACCCTTCTCTGATTTCAAACCACCAGTCCCTTTACCTCTCAGAGAAAACAGCAACCACAAAAGCCTC
TCCACTTCCTACTATCTTAATATTGACAACTTCCAGATCAGGGAGCTGAGATATCTCAAGCTCAGGTTTCTCTTCTGAGCTTCAGACGCT
TTTATCCACTTGGATTTCACTGGCACAAAACTTTCCATGTTAGAATCAAACCCCCCTCCTCCCAGACCTGCTTCTCCCACACACTTCCCT
ATCTGAATGAAAGACACCTCCACTCTCCACCCAGTTGCCAAATCAGAAATCTGTCTTTGTTTTCTTTGTCTCACATTTTCCTATGTCTAA
TCAGTTAAGTTTTATCAATACTACCTGTTTATTTCTTTAATCTATTCACATATCTTTATCCTCAATCTTCAGCATCCCCTTCCCATCCTC
AGTCTGCTGGTTACTGTATTTCCTATTTTACTAAGAATCTAAAAGAGATCAGAAGAAAACTTCCACATCCCCCAACACCCAACCACCAAA
TCTGCTAACCCAGTTGCATTGGTGCTTTTATAGCCTTCCTTCCTCCCTCTTACTAAGAATGAACCAACACTATTCCTATCAAAGCCCAAC
CCTCTAGCTTTACATTGACTCCTAGTGTCTTTTTTCTGGATTGTCAATTTTTTTCCTGACCAATTATTCTATTAGCAATACAAATATGCT
GTAAAATCTCTTAAACTTTTTTCTCTGCATCTTTGAACTGCTGTTCTCTTTTCCTTCTCCCCTTCATAGCAGAACTCCTCAAAAGAGTTG
CTACCTCTAATTCTTCCCTTCCAGTTCTCTCATGAACCAGCTACAATTAAGTATTCACCCCCACCACTCCATGGAAACTGCTCTTGTCAA
AATCATCAATAGCCTTTGTGTGGTGAATCCAATAGCCAGTTTTCATTCTTCTTACTAAGCTTCTCATCAGTATTCCTAGACTATTTCCTT
CACTGGCTTCGACAAATGCTTTCTTGGTTTTCCTCCAATTTCTCGACTTTGTTCCTGCTGAATCTACCTTTTTCTAATCCGTAAGTGTTG
GGGTGTCCCAGGGCTTACTCCTTGGACCTTTTTTCCACCTTTTCCCCTACACTCACCCACTAGGTGATCTCAAGAATTTCCAGTTTGAGG
CCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGCCAGGAGTTCGAGACCAGCCTG
GCCAACATGGCAAAACCCTGTCTCCACTAAACCTGCCTCTACTAAAAATACAAAAATTATTATATTTTTATAAAATTATTATAATTTTAT
AAAATTATTATATTTATGGAGTACAATGTGATGTAATCCCAGCTACTCGGAAGGCTGTATGTGTCTATTTATGGAGTACAATGTGCCTGT
AATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTCAACCTAGGAGGCAGAGGTTGTGCTGAGCCAAGATCGTGCCATTGCACTC
CAGCCTGGGCAACAAGAGAGAAATAACATCTCAAAAAAAAAAAAAAAGAATTTCCAGTTTTAAATATTTACACAATGTCTCCTAAATTTA
TACCTTCAACCTAGACCTTTCCCTGTGAATCCCAGTCTCATTTCCAACAGTCTAATCAATGTCTCTATTTGGATGTTTAAGATATACAAT
AGGTATCAAACTTCCCATTGTCCACAATAAACTCTCAATTTCCGTGCCTTTTCAAACTTACTCCTTCCACAGGCTTTCCCATCTAGGTAA
ATGACACCACCATTCACCCTGTTGCTTTGGCCAAGAACTTTAGAACTGCCCTTGACTCCCCTCTTTTTCTCATATCCTACCTCTACTACA
TCAGTAACTCCTGTTGTATCTCTCTTCAAACTATATCCAGAATTGACCATGTCCCAATACTTCCATTGCTACTGTCTTAGTCCCAGTGTC
ATCTTTTACCTGGATTATTGTAAAGGCCTCGTAACTAGTCTTCCTGTTTCTGCCCTTCCCTTCTCTGCCCATCTATTCTCAACACAGTGT
TGCTTTTAAAACAAAGTAAGATCGTGCCACTCTTCTGCTCTAAATTCCCCATTGGTTTCTCATCTCAAACTAAGGGCCAGTCATAATGCC
CTCACGGTCCTATGACATCTCACTGCACCCCAGCCATACTCGCCATCTTACCATTCTTCTTCTTTTTTGTAATAAAAACTTTTTACTTTC
TTTTTAGTTGACAGATAATAATTGCGTATATTTATGGAGTACAATGTGATGTTTTGATATATGTATGCATGAGGGAATGATTAAATCAAG
CTAATTAACATATTCATCACTTCATCTACTCATCACTTTCTTGTGGTGAAAATGTTTCAGATATACTCTTTAGTAGTTTTCAGGTGTACA
GTCGCTGTGGTTTGAGTGCTTTTGTCTTCTCTAAATTTGATGTTGACACTTAGTGCCCAGTACAATGTTACTGGGAGGTGGAGCCTAATG
GGGATGTTTAATGGATTAATGCCATTATAAAAAGGGCTTGCAGGAATGGGTTCCTTCTCTTTTGCTTTTCTGCCATATGATGACAAAGTG
TTCCTCCTCTCTGGAGGATGCAGCAACAGGCACCATCTTTGAAGCAGAGAGACCAGGCCCTAACCTTCTGGTGCCTTGATCTTGGACTTC
TCAGCTTCCAGAACTGTGAGATAATAAATTTCTGTTCATTACAAATTACCCCATCTGTGGTATTCTGTTATAGCAACACAAAATGGACTA
AGACAACAGTATACTGTTATGAACTATGGTCACCATGCTGTGCACTAGATCACAAAAACTTATTTCTACTGTTTAACTGAAACTTTGTAC
ATTTTGACTAACATCTCCCTTTTTCCCATCATCCCATCCCATTCTTACTATCGTTGAAGATGGAGTATGCCAAGTAGTCCTGAGCCATGT
CCTCACCTCGGGGTGAGCACCTGTTGTTCCTGTGCCTGGAATGCTCTCCTAGACATTTGCGTGGCTAGCTCCCTCTTTTCATTCAGATCT
CAGCTCATTGTCATCTCAGAGAGGCCCTCCTTGCCCTCCTTCTACCTCCTGCCTTAGGTATACTCTGCCACCTTCTGTCATGGGCTGAAT
TGTGTCCCCCCTAAATCCATATGTTGACATCTTAACCCCTAGTACAGTAAGTCCTCACTTGATGCTATCAATAGGCTCTTGGAAATGTCG
GCTTTCAGTGAAAGGACATATAGCAGGTCCTTGAATAACATTGTGTTTTGTTCAACATCGTTGCCTTGTAACACTGATGAGCAAAACAGT
TGGTTCTCTAATATGTTGTTTTACTTAAAGCTACAGTTTCCAAGAACCTATCAATGATGTTGAGGACTGAATGTACCTCAGGTGTAATGT
ATTTGGAGATAGGGCCTTTTAAGAGGTAAAGTAAATGAGGTCATATGGGTAGGCTGTAATCCAATATGACTGGAATCCTTATAAGAAGAG
GAAATGAGGACACAGACACAGAGGGAAGATGACTATCTGCAAGTCAAGGAGAGAGGCCTCAGAAGAAACCAATGCTGCTGACACCACGAT
CTTGGACTTCTAGCCTCTAGCACTGTGAGGAAATAAATTTCTGTTGTTTAAGCCACCTAGTCTGTGATACTTTGCTACGGCAGGCCCTAG
CAAATGAATACACTTGTCTTGTCTTTCCCCCGCCCTGTGATATTTATCAGTGCCGGATATTACATATTTGTGTATCTATATGCTTATTTC
CCTGACTAAAATGGAAGCTCCATGAAGGCAGATTTCCTCTTGTTCACTGATGTGTCCCCAGCACCTGGAATAGTGCCTAGTGCATGCCAG
TGCTCAGACACTTGGACATTTGAATGACATATCCCCTCTGTCACTTCTCTCCGGGGCCCAAGGCCACCCTCCTAGGTTACCACAGTGGCT
TCCTAATGGGCCATACCCTCACTTGCTTTCCATCACCCCCTGAGACCTGGCCCCTGCATACCTCTCCAGCTTCACCCCTCACATATCTCC
CTAGCCAGACCTATAGTATGTTTTAAAAAAAAAGGAAATCGCACTCCTCTGGCCTCTTTACCTTGGCACACATTTTTCCATCACCTGACC
CCTGACCCACACTCCCTTTTCCTGTGTAATCCAATTATCTCTAGGCCTCCCGTGTTTCTGTTTGTCCTTCAATAGAAGGTTGTTTGTCTT
GTCTTTTATTGTATTTCTAGAACCAAGTGCAGAGACTGTACAAAGTGGACCTCAGCAAAGATTTACCGAATGAATAAATGAGTTCAGAAC

>6308_6308_4_ARHGEF3-ACP6_ARHGEF3_chr3_56916320_ENST00000496106_ACP6_chr1_147131890_ENST00000369238_length(amino acids)=403AA_BP=48
MQLGAGESGWMRSERPMVWCCLFVRSQRKRKQSTQDEDAVSLCSLDISVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTL
KGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNY
QSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDRE
SLQMAVGPFLHILESNLLKAVDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVP

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Fusion Gene PPI Analysis for ARHGEF3-ACP6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ARHGEF3-ACP6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ARHGEF3-ACP6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source