FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARHGEF3-ARF4 (FusionGDB2 ID:6310)

Fusion Gene Summary for ARHGEF3-ARF4

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF3-ARF4
Fusion gene ID: 6310
HgeneTgene
Gene symbol

ARHGEF3

ARF4

Gene ID

50650

378

Gene nameRho guanine nucleotide exchange factor 3ADP ribosylation factor 4
SynonymsGEF3|STA3|XPLNARF2
Cytomap

3p14.3

3p14.3

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 359.8 kDA proteinRho guanine nucleotide exchange factor (GEF) 3RhoGEF proteinexchange factor found in platelets and leukemic and neuronal tissues, XPLNADP-ribosylation factor 4ADP-ribosylation factor 2
Modification date2020032720200313
UniProtAcc.

P18085

Ensembl transtripts involved in fusion geneENST00000338458, ENST00000496106, 
ENST00000498517, ENST00000296315, 
ENST00000413728, ENST00000495373, 
ENST00000497267, 		ENST00000493378, 
ENST00000303436, ENST00000489843, 
ENST00000496292, 
Fusion gene scores* DoF score19 X 17 X 8=25847 X 6 X 5=210
# samples 237
** MAII scorelog2(23/2584*10)=-3.48990030374955
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGEF3 [Title/Abstract] AND ARF4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF3(56916320)-ARF4(57558025), # samples:2
Anticipated loss of major functional domain due to fusion event.ARHGEF3-ARF4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARHGEF3-ARF4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARF4

GO:0006471

protein ADP-ribosylation

1899243

TgeneARF4

GO:0016477

cell migration

22004728

TgeneARF4

GO:0031584

activation of phospholipase D activity

12446727

TgeneARF4

GO:0043066

negative regulation of apoptotic process

19041174

TgeneARF4

GO:0045944

positive regulation of transcription by RNA polymerase II

12446727

TgeneARF4

GO:0060996

dendritic spine development

23050017

TgeneARF4

GO:2000377

regulation of reactive oxygen species metabolic process

19041174


check buttonFusion gene breakpoints across ARHGEF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARF4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-HZ-8637-01AARHGEF3chr3

56916320

-ARF4chr3

57558025

-
ChimerDB4PAADTCGA-HZ-8637ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
ChimerDB4PAADTCGA-HZ-8637ARHGEF3chr3

56916320

-ARF4chr3

57558025

-


Top

Fusion Gene ORF analysis for ARHGEF3-ARF4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000338458ENST00000493378ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
5CDS-intronENST00000338458ENST00000493378ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
5CDS-intronENST00000496106ENST00000493378ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
5CDS-intronENST00000496106ENST00000493378ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
5UTR-3CDSENST00000498517ENST00000303436ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
5UTR-3CDSENST00000498517ENST00000303436ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
5UTR-3CDSENST00000498517ENST00000489843ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
5UTR-3CDSENST00000498517ENST00000489843ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
5UTR-3CDSENST00000498517ENST00000496292ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
5UTR-3CDSENST00000498517ENST00000496292ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
5UTR-intronENST00000498517ENST00000493378ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
5UTR-intronENST00000498517ENST00000493378ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
Frame-shiftENST00000338458ENST00000489843ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
Frame-shiftENST00000338458ENST00000489843ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
Frame-shiftENST00000338458ENST00000496292ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
Frame-shiftENST00000338458ENST00000496292ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
Frame-shiftENST00000496106ENST00000489843ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
Frame-shiftENST00000496106ENST00000489843ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
Frame-shiftENST00000496106ENST00000496292ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
Frame-shiftENST00000496106ENST00000496292ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
In-frameENST00000338458ENST00000303436ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
In-frameENST00000338458ENST00000303436ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
In-frameENST00000496106ENST00000303436ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
In-frameENST00000496106ENST00000303436ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-3CDSENST00000296315ENST00000303436ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-3CDSENST00000296315ENST00000303436ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-3CDSENST00000296315ENST00000489843ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-3CDSENST00000296315ENST00000489843ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-3CDSENST00000296315ENST00000496292ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-3CDSENST00000296315ENST00000496292ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-3CDSENST00000413728ENST00000303436ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-3CDSENST00000413728ENST00000303436ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-3CDSENST00000413728ENST00000489843ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-3CDSENST00000413728ENST00000489843ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-3CDSENST00000413728ENST00000496292ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-3CDSENST00000413728ENST00000496292ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-3CDSENST00000495373ENST00000303436ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-3CDSENST00000495373ENST00000303436ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-3CDSENST00000495373ENST00000489843ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-3CDSENST00000495373ENST00000489843ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-3CDSENST00000495373ENST00000496292ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-3CDSENST00000495373ENST00000496292ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-3CDSENST00000497267ENST00000303436ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-3CDSENST00000497267ENST00000303436ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-3CDSENST00000497267ENST00000489843ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-3CDSENST00000497267ENST00000489843ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-3CDSENST00000497267ENST00000496292ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-3CDSENST00000497267ENST00000496292ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-intronENST00000296315ENST00000493378ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-intronENST00000296315ENST00000493378ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-intronENST00000413728ENST00000493378ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-intronENST00000413728ENST00000493378ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-intronENST00000495373ENST00000493378ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-intronENST00000495373ENST00000493378ARHGEF3chr3

56916320

-ARF4chr3

57558025

-
intron-intronENST00000497267ENST00000493378ARHGEF3chr3

56916319

-ARF4chr3

57558025

-
intron-intronENST00000497267ENST00000493378ARHGEF3chr3

56916320

-ARF4chr3

57558025

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338458ARHGEF3chr356916319-ENST00000303436ARF4chr357558025-12383023312110
ENST00000496106ARHGEF3chr356916319-ENST00000303436ARF4chr357558025-11622268231276
ENST00000338458ARHGEF3chr356916320-ENST00000303436ARF4chr357558025-12383023312110
ENST00000496106ARHGEF3chr356916320-ENST00000303436ARF4chr357558025-11622268231276

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338458ENST00000303436ARHGEF3chr356916319-ARF4chr357558025-0.1097270850.8902729
ENST00000496106ENST00000303436ARHGEF3chr356916319-ARF4chr357558025-0.57451160.42548844
ENST00000338458ENST00000303436ARHGEF3chr356916320-ARF4chr357558025-0.1097270850.8902729
ENST00000496106ENST00000303436ARHGEF3chr356916320-ARF4chr357558025-0.57451160.42548844

Top

Fusion Genomic Features for ARHGEF3-ARF4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ARHGEF3-ARF4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:56916320/chr3:57558025)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARF4

P18085

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF3chr3:56916319chr3:57558025ENST00000296315-110122_3040527.0DomainDH
HgeneARHGEF3chr3:56916319chr3:57558025ENST00000296315-110291_4490527.0DomainPH
HgeneARHGEF3chr3:56916319chr3:57558025ENST00000338458-413122_30464559.0DomainDH
HgeneARHGEF3chr3:56916319chr3:57558025ENST00000338458-413291_44964559.0DomainPH
HgeneARHGEF3chr3:56916319chr3:57558025ENST00000413728-110122_3040533.0DomainDH
HgeneARHGEF3chr3:56916319chr3:57558025ENST00000413728-110291_4490533.0DomainPH
HgeneARHGEF3chr3:56916320chr3:57558025ENST00000296315-110122_3040527.0DomainDH
HgeneARHGEF3chr3:56916320chr3:57558025ENST00000296315-110291_4490527.0DomainPH
HgeneARHGEF3chr3:56916320chr3:57558025ENST00000338458-413122_30464559.0DomainDH
HgeneARHGEF3chr3:56916320chr3:57558025ENST00000338458-413291_44964559.0DomainPH
HgeneARHGEF3chr3:56916320chr3:57558025ENST00000413728-110122_3040533.0DomainDH
HgeneARHGEF3chr3:56916320chr3:57558025ENST00000413728-110291_4490533.0DomainPH
TgeneARF4chr3:56916319chr3:57558025ENST0000030343646126_129152181.0Nucleotide bindingNote=GTP
TgeneARF4chr3:56916319chr3:57558025ENST000003034364624_31152181.0Nucleotide bindingNote=GTP
TgeneARF4chr3:56916319chr3:57558025ENST000003034364667_71152181.0Nucleotide bindingNote=GTP
TgeneARF4chr3:56916320chr3:57558025ENST0000030343646126_129152181.0Nucleotide bindingNote=GTP
TgeneARF4chr3:56916320chr3:57558025ENST000003034364624_31152181.0Nucleotide bindingNote=GTP
TgeneARF4chr3:56916320chr3:57558025ENST000003034364667_71152181.0Nucleotide bindingNote=GTP


Top

Fusion Gene Sequence for ARHGEF3-ARF4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6310_6310_1_ARHGEF3-ARF4_ARHGEF3_chr3_56916319_ENST00000338458_ARF4_chr3_57558025_ENST00000303436_length(transcript)=1238nt_BP=302nt
AGCCCAGGGGAGCCGCCGCCGCAGCCGCCGCCGCCGCGGTGAGTTTTCCAGCCTGGAGAGGCCGAACCAGCGCGGGGGTCGAGGAGACCT
GAGCCTGCCATACTGAGTCTATGGACAGTTCCACAGCAATGAATCAATGCAGCTGTAGAGGAATGGAAGAAAACAAGGAAAGGCCTAAAC
GGCAGCGGCAAAACAACTTTCCCATGTTTCCCTCTCCTAAAGCCTGGAATTTCAGAGGGCGAAAACGGAAACAGAGCACCCAAGATGAAG
ATGCTGTTAGCCTTTGCAGTCTCGACATAAGTTGGTATGTTCAAGCCACTTGTGCAACACAAGGAACTGGTCTGTATGAAGGACTTGACT
GGCTGTCAAATGAGCTTTCAAAACGTTAAATGAAATTGGATATCTAACCAAGGACATGTTTGATAAAATTGGTCTAGGCTTGTTACAACA
AAATTAGTTTGTATCTTGGTTATTAAACAGTATCTGGGACTGGTTTGGGCAGAATATTAAACTTATTTTGTTGCCAATTATTGTTTACCG
AGTATAATGTTGCTATTTAGCAATGTGCTTGGTTTTAAAGAAATTCTCCTTGGGAAAAAAGTATCCTCTTTTAATTTTACTTCCCATAAG
CGTAAATGCCTGGACATAGCTCTTGTGCAACCTTTAAATAAATTGTTTTGAGTGTTTTTTGAGCCCCAGACAAATAATGTTTTAAAGTTA
TCCCCTTGCTACTTTACTGATACCTTTATCATTCCTGAGACAGTTTGCTAATTTAAAAATGTAGCATTCCATTTGTATTTATTTCTCTCC
CTTGCCAAAAAGATTTTCTAATACTGCTTGTACCAGCCAGAGAAAGATCCAAAACACTACTCAGCTCTCTTGCACTGAGGAAATTTTTCC
CCCTACATTGACTCCTGGCCTACATCAGCCAAACTTAACCTTGGTGGGGTTTGGATTTGATAGCCAATTAGTTCTGTGCTGGTTGCAAAG
AATTGATATTTAGATGGTTTTTAATACTCAGCAGATTGTCTTCCTTTATATTGTGTCTTTTTTATGTTGCATGTTGCTTTTGTTATCAGC
CTGATTTTTTGCTCAGTATATGATAGTTCTGCTGATGTTTTGTTTATTGGGCAGACATATCTTCATTAAGAGTTTTTGGAAAACTCATCA

>6310_6310_1_ARHGEF3-ARF4_ARHGEF3_chr3_56916319_ENST00000338458_ARF4_chr3_57558025_ENST00000303436_length(amino acids)=110AA_BP=
MCCTSGLNIPTYVETAKANSIFILGALFPFSPSEIPGFRRGKHGKVVLPLPFRPFLVFFHSSTAALIHCCGTVHRLSMAGSGLLDPRAGS

--------------------------------------------------------------
>6310_6310_2_ARHGEF3-ARF4_ARHGEF3_chr3_56916319_ENST00000496106_ARF4_chr3_57558025_ENST00000303436_length(transcript)=1162nt_BP=226nt
ATGCAGCCCAAGTGGCGGGGAGGAGTTCCTTCAGGGAAACTATGCTCAGCCCTGTTCAGAGAATCCTGTGCACAGGGCTCCACTGCAGTT
AGGAGCCGGTGAGTCCGGGTGGATGAGGTCAGAGCGCCCCATGGTGTGGTGCTGCCTCTTTGTCCGTTCGCAGCGAAAACGGAAACAGAG
CACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGTTGGTATGTTCAAGCCACTTGTGCAACACAAGGAACTGGTCTGTA
TGAAGGACTTGACTGGCTGTCAAATGAGCTTTCAAAACGTTAAATGAAATTGGATATCTAACCAAGGACATGTTTGATAAAATTGGTCTA
GGCTTGTTACAACAAAATTAGTTTGTATCTTGGTTATTAAACAGTATCTGGGACTGGTTTGGGCAGAATATTAAACTTATTTTGTTGCCA
ATTATTGTTTACCGAGTATAATGTTGCTATTTAGCAATGTGCTTGGTTTTAAAGAAATTCTCCTTGGGAAAAAAGTATCCTCTTTTAATT
TTACTTCCCATAAGCGTAAATGCCTGGACATAGCTCTTGTGCAACCTTTAAATAAATTGTTTTGAGTGTTTTTTGAGCCCCAGACAAATA
ATGTTTTAAAGTTATCCCCTTGCTACTTTACTGATACCTTTATCATTCCTGAGACAGTTTGCTAATTTAAAAATGTAGCATTCCATTTGT
ATTTATTTCTCTCCCTTGCCAAAAAGATTTTCTAATACTGCTTGTACCAGCCAGAGAAAGATCCAAAACACTACTCAGCTCTCTTGCACT
GAGGAAATTTTTCCCCCTACATTGACTCCTGGCCTACATCAGCCAAACTTAACCTTGGTGGGGTTTGGATTTGATAGCCAATTAGTTCTG
TGCTGGTTGCAAAGAATTGATATTTAGATGGTTTTTAATACTCAGCAGATTGTCTTCCTTTATATTGTGTCTTTTTTATGTTGCATGTTG
CTTTTGTTATCAGCCTGATTTTTTGCTCAGTATATGATAGTTCTGCTGATGTTTTGTTTATTGGGCAGACATATCTTCATTAAGAGTTTT

>6310_6310_2_ARHGEF3-ARF4_ARHGEF3_chr3_56916319_ENST00000496106_ARF4_chr3_57558025_ENST00000303436_length(amino acids)=76AA_BP=48

--------------------------------------------------------------
>6310_6310_3_ARHGEF3-ARF4_ARHGEF3_chr3_56916320_ENST00000338458_ARF4_chr3_57558025_ENST00000303436_length(transcript)=1238nt_BP=302nt
AGCCCAGGGGAGCCGCCGCCGCAGCCGCCGCCGCCGCGGTGAGTTTTCCAGCCTGGAGAGGCCGAACCAGCGCGGGGGTCGAGGAGACCT
GAGCCTGCCATACTGAGTCTATGGACAGTTCCACAGCAATGAATCAATGCAGCTGTAGAGGAATGGAAGAAAACAAGGAAAGGCCTAAAC
GGCAGCGGCAAAACAACTTTCCCATGTTTCCCTCTCCTAAAGCCTGGAATTTCAGAGGGCGAAAACGGAAACAGAGCACCCAAGATGAAG
ATGCTGTTAGCCTTTGCAGTCTCGACATAAGTTGGTATGTTCAAGCCACTTGTGCAACACAAGGAACTGGTCTGTATGAAGGACTTGACT
GGCTGTCAAATGAGCTTTCAAAACGTTAAATGAAATTGGATATCTAACCAAGGACATGTTTGATAAAATTGGTCTAGGCTTGTTACAACA
AAATTAGTTTGTATCTTGGTTATTAAACAGTATCTGGGACTGGTTTGGGCAGAATATTAAACTTATTTTGTTGCCAATTATTGTTTACCG
AGTATAATGTTGCTATTTAGCAATGTGCTTGGTTTTAAAGAAATTCTCCTTGGGAAAAAAGTATCCTCTTTTAATTTTACTTCCCATAAG
CGTAAATGCCTGGACATAGCTCTTGTGCAACCTTTAAATAAATTGTTTTGAGTGTTTTTTGAGCCCCAGACAAATAATGTTTTAAAGTTA
TCCCCTTGCTACTTTACTGATACCTTTATCATTCCTGAGACAGTTTGCTAATTTAAAAATGTAGCATTCCATTTGTATTTATTTCTCTCC
CTTGCCAAAAAGATTTTCTAATACTGCTTGTACCAGCCAGAGAAAGATCCAAAACACTACTCAGCTCTCTTGCACTGAGGAAATTTTTCC
CCCTACATTGACTCCTGGCCTACATCAGCCAAACTTAACCTTGGTGGGGTTTGGATTTGATAGCCAATTAGTTCTGTGCTGGTTGCAAAG
AATTGATATTTAGATGGTTTTTAATACTCAGCAGATTGTCTTCCTTTATATTGTGTCTTTTTTATGTTGCATGTTGCTTTTGTTATCAGC
CTGATTTTTTGCTCAGTATATGATAGTTCTGCTGATGTTTTGTTTATTGGGCAGACATATCTTCATTAAGAGTTTTTGGAAAACTCATCA

>6310_6310_3_ARHGEF3-ARF4_ARHGEF3_chr3_56916320_ENST00000338458_ARF4_chr3_57558025_ENST00000303436_length(amino acids)=110AA_BP=
MCCTSGLNIPTYVETAKANSIFILGALFPFSPSEIPGFRRGKHGKVVLPLPFRPFLVFFHSSTAALIHCCGTVHRLSMAGSGLLDPRAGS

--------------------------------------------------------------
>6310_6310_4_ARHGEF3-ARF4_ARHGEF3_chr3_56916320_ENST00000496106_ARF4_chr3_57558025_ENST00000303436_length(transcript)=1162nt_BP=226nt
ATGCAGCCCAAGTGGCGGGGAGGAGTTCCTTCAGGGAAACTATGCTCAGCCCTGTTCAGAGAATCCTGTGCACAGGGCTCCACTGCAGTT
AGGAGCCGGTGAGTCCGGGTGGATGAGGTCAGAGCGCCCCATGGTGTGGTGCTGCCTCTTTGTCCGTTCGCAGCGAAAACGGAAACAGAG
CACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGTTGGTATGTTCAAGCCACTTGTGCAACACAAGGAACTGGTCTGTA
TGAAGGACTTGACTGGCTGTCAAATGAGCTTTCAAAACGTTAAATGAAATTGGATATCTAACCAAGGACATGTTTGATAAAATTGGTCTA
GGCTTGTTACAACAAAATTAGTTTGTATCTTGGTTATTAAACAGTATCTGGGACTGGTTTGGGCAGAATATTAAACTTATTTTGTTGCCA
ATTATTGTTTACCGAGTATAATGTTGCTATTTAGCAATGTGCTTGGTTTTAAAGAAATTCTCCTTGGGAAAAAAGTATCCTCTTTTAATT
TTACTTCCCATAAGCGTAAATGCCTGGACATAGCTCTTGTGCAACCTTTAAATAAATTGTTTTGAGTGTTTTTTGAGCCCCAGACAAATA
ATGTTTTAAAGTTATCCCCTTGCTACTTTACTGATACCTTTATCATTCCTGAGACAGTTTGCTAATTTAAAAATGTAGCATTCCATTTGT
ATTTATTTCTCTCCCTTGCCAAAAAGATTTTCTAATACTGCTTGTACCAGCCAGAGAAAGATCCAAAACACTACTCAGCTCTCTTGCACT
GAGGAAATTTTTCCCCCTACATTGACTCCTGGCCTACATCAGCCAAACTTAACCTTGGTGGGGTTTGGATTTGATAGCCAATTAGTTCTG
TGCTGGTTGCAAAGAATTGATATTTAGATGGTTTTTAATACTCAGCAGATTGTCTTCCTTTATATTGTGTCTTTTTTATGTTGCATGTTG
CTTTTGTTATCAGCCTGATTTTTTGCTCAGTATATGATAGTTCTGCTGATGTTTTGTTTATTGGGCAGACATATCTTCATTAAGAGTTTT

>6310_6310_4_ARHGEF3-ARF4_ARHGEF3_chr3_56916320_ENST00000496106_ARF4_chr3_57558025_ENST00000303436_length(amino acids)=76AA_BP=48

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARHGEF3-ARF4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARHGEF3-ARF4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARHGEF3-ARF4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource