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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PCBP2-CCT5 (FusionGDB2 ID:63102)

Fusion Gene Summary for PCBP2-CCT5

check button Fusion gene summary
Fusion gene informationFusion gene name: PCBP2-CCT5
Fusion gene ID: 63102
HgeneTgene
Gene symbol

PCBP2

CCT5

Gene ID

5094

22948

Gene namepoly(rC) binding protein 2chaperonin containing TCP1 subunit 5
SynonymsHNRNPE2|HNRPE2|hnRNP-E2CCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon
Cytomap

12q13.13

5p15.2

Type of geneprotein-codingprotein-coding
Descriptionpoly(rC)-binding protein 2alpha-CP2epididymis secretory sperm binding proteinheterogeneous nuclear ribonucleoprotein E2heterogenous nuclear ribonucleoprotein E2hnRNP E2T-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69
Modification date2020031320200313
UniProtAcc.

P48643

Ensembl transtripts involved in fusion geneENST00000437231, ENST00000447282, 
ENST00000455667, ENST00000603815, 
ENST00000359282, ENST00000359462, 
ENST00000439930, ENST00000541275, 
ENST00000546463, ENST00000548933, 
ENST00000549863, ENST00000552296, 
ENST00000552819, 		ENST00000280326, 
ENST00000503026, ENST00000506600, 
ENST00000515390, ENST00000515676, 
Fusion gene scores* DoF score34 X 29 X 12=1183258 X 14 X 17=13804
# samples 4561
** MAII scorelog2(45/11832*10)=-4.71662514588203
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(61/13804*10)=-4.50013332598527
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCBP2 [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPCBP2(53873616)-CCT5(10250033), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePCBP2

GO:0039694

viral RNA genome replication

12414943

HgenePCBP2

GO:0075522

IRES-dependent viral translational initiation

12414943


check buttonFusion gene breakpoints across PCBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-BI-A0VS-01APCBP2chr12

53873616

-CCT5chr5

10250033

+


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Fusion Gene ORF analysis for PCBP2-CCT5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000437231ENST00000280326PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-3CDSENST00000447282ENST00000280326PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-3CDSENST00000455667ENST00000280326PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-3CDSENST00000603815ENST00000280326PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000437231ENST00000503026PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000437231ENST00000506600PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000437231ENST00000515390PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000437231ENST00000515676PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000447282ENST00000503026PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000447282ENST00000506600PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000447282ENST00000515390PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000447282ENST00000515676PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000455667ENST00000503026PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000455667ENST00000506600PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000455667ENST00000515390PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000455667ENST00000515676PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000603815ENST00000503026PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000603815ENST00000506600PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000603815ENST00000515390PCBP2chr12

53873616

-CCT5chr5

10250033

+
3UTR-intronENST00000603815ENST00000515676PCBP2chr12

53873616

-CCT5chr5

10250033

+
5CDS-intronENST00000359282ENST00000503026PCBP2chr12

53873616

-CCT5chr5

10250033

+
5CDS-intronENST00000359282ENST00000506600PCBP2chr12

53873616

-CCT5chr5

10250033

+
5CDS-intronENST00000359282ENST00000515390PCBP2chr12

53873616

-CCT5chr5

10250033

+
5CDS-intronENST00000359282ENST00000515676PCBP2chr12

53873616

-CCT5chr5

10250033

+
5CDS-intronENST00000359462ENST00000503026PCBP2chr12

53873616

-CCT5chr5

10250033

+
5CDS-intronENST00000359462ENST00000506600PCBP2chr12

53873616

-CCT5chr5

10250033

+
5CDS-intronENST00000359462ENST00000515390PCBP2chr12

53873616

-CCT5chr5

10250033

+
5CDS-intronENST00000359462ENST00000515676PCBP2chr12

53873616

-CCT5chr5

10250033

+
In-frameENST00000359282ENST00000280326PCBP2chr12

53873616

-CCT5chr5

10250033

+
In-frameENST00000359462ENST00000280326PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-3CDSENST00000439930ENST00000280326PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-3CDSENST00000541275ENST00000280326PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-3CDSENST00000546463ENST00000280326PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-3CDSENST00000548933ENST00000280326PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-3CDSENST00000549863ENST00000280326PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-3CDSENST00000552296ENST00000280326PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-3CDSENST00000552819ENST00000280326PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000439930ENST00000503026PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000439930ENST00000506600PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000439930ENST00000515390PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000439930ENST00000515676PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000541275ENST00000503026PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000541275ENST00000506600PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000541275ENST00000515390PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000541275ENST00000515676PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000546463ENST00000503026PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000546463ENST00000506600PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000546463ENST00000515390PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000546463ENST00000515676PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000548933ENST00000503026PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000548933ENST00000506600PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000548933ENST00000515390PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000548933ENST00000515676PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000549863ENST00000503026PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000549863ENST00000506600PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000549863ENST00000515390PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000549863ENST00000515676PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000552296ENST00000503026PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000552296ENST00000506600PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000552296ENST00000515390PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000552296ENST00000515676PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000552819ENST00000503026PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000552819ENST00000506600PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000552819ENST00000515390PCBP2chr12

53873616

-CCT5chr5

10250033

+
intron-intronENST00000552819ENST00000515676PCBP2chr12

53873616

-CCT5chr5

10250033

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359282PCBP2chr1253873616-ENST00000280326CCT5chr510250033+5405173021203775551
ENST00000359462PCBP2chr1253873616-ENST00000280326CCT5chr510250033+5489181422043859551

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359282ENST00000280326PCBP2chr1253873616-CCT5chr510250033+0.0011560170.9988439
ENST00000359462ENST00000280326PCBP2chr1253873616-CCT5chr510250033+0.0010991830.9989008

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Fusion Genomic Features for PCBP2-CCT5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PCBP2-CCT5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:53873616/chr5:10250033)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCT5

P48643

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCBP2chr12:53873616chr5:10250033ENST00000359282-141413_75460332.0DomainKH 1
HgenePCBP2chr12:53873616chr5:10250033ENST00000359282-1414287_351460332.0DomainKH 3
HgenePCBP2chr12:53873616chr5:10250033ENST00000359282-141497_162460332.0DomainKH 2
HgenePCBP2chr12:53873616chr5:10250033ENST00000359462-151513_75497367.0DomainKH 1
HgenePCBP2chr12:53873616chr5:10250033ENST00000359462-1515287_351497367.0DomainKH 3
HgenePCBP2chr12:53873616chr5:10250033ENST00000359462-151597_162497367.0DomainKH 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCBP2chr12:53873616chr5:10250033ENST00000439930-11413_750366.0DomainKH 1
HgenePCBP2chr12:53873616chr5:10250033ENST00000439930-114287_3510366.0DomainKH 3
HgenePCBP2chr12:53873616chr5:10250033ENST00000439930-11497_1620366.0DomainKH 2
HgenePCBP2chr12:53873616chr5:10250033ENST00000447282-11413_750336.0DomainKH 1
HgenePCBP2chr12:53873616chr5:10250033ENST00000447282-114287_3510336.0DomainKH 3
HgenePCBP2chr12:53873616chr5:10250033ENST00000447282-11497_1620336.0DomainKH 2
HgenePCBP2chr12:53873616chr5:10250033ENST00000546463-11513_750363.0DomainKH 1
HgenePCBP2chr12:53873616chr5:10250033ENST00000546463-115287_3510363.0DomainKH 3
HgenePCBP2chr12:53873616chr5:10250033ENST00000546463-11597_1620363.0DomainKH 2
HgenePCBP2chr12:53873616chr5:10250033ENST00000548933-11313_750336.0DomainKH 1
HgenePCBP2chr12:53873616chr5:10250033ENST00000548933-113287_3510336.0DomainKH 3
HgenePCBP2chr12:53873616chr5:10250033ENST00000548933-11397_1620336.0DomainKH 2
HgenePCBP2chr12:53873616chr5:10250033ENST00000552296-11513_750362.0DomainKH 1
HgenePCBP2chr12:53873616chr5:10250033ENST00000552296-115287_3510362.0DomainKH 3
HgenePCBP2chr12:53873616chr5:10250033ENST00000552296-11597_1620362.0DomainKH 2
HgenePCBP2chr12:53873616chr5:10250033ENST00000603815-11513_750366.0DomainKH 1
HgenePCBP2chr12:53873616chr5:10250033ENST00000603815-115287_3510366.0DomainKH 3
HgenePCBP2chr12:53873616chr5:10250033ENST00000603815-11597_1620366.0DomainKH 2


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Fusion Gene Sequence for PCBP2-CCT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63102_63102_1_PCBP2-CCT5_PCBP2_chr12_53873616_ENST00000359282_CCT5_chr5_10250033_ENST00000280326_length(transcript)=5405nt_BP=1730nt
CCCAGACCAGCAGAGGCAGCAGCCGGAGCAGCCGCAGCCTGCGCCCTCTCCCGCCCGCCCGCCCTCCGCCCGCCCGCCCGCCCTCCGCCG
CCCTCCACCCGCCCCGGGGTCTCTTTCCCCCTTCCTCCTCCTCCTCCTCCACCCCCCCTTCCTCCTCCGCCCGCCCGCGGGGCCCCCCTC
GCCTTCCCGCCCGCCCCTATTGTTCCGCCCCCGGCCTCCCGCCCTTCCCCTTCCCGCCCGCTCCCCTTTTCCCCTCAGTCGCCTCGCGCC
TGCAGTTTTTGGCTTTCACCCCCAACCAGTGACCAAAGACTTGACCACTCAAAGTCCAGCTCCCCAGAACACTGCTCGACATGGACACCG
GTGTGATTGAAGGTGGATTAAATGTCACTCTCACCATCCGGCTACTTATGCATGGAAAGGAAGTTGGCAGTATCATCGGAAAGAAAGGAG
AATCAGTTAAGAAGATGCGCGAGGAGAGTGGTGCACGTATCAACATCTCAGAAGGGAATTGTCCTGAGAGAATTATCACTTTGGCTGGAC
CCACTAATGCCATCTTCAAAGCCTTTGCTATGATCATTGACAAACTGGAAGAGGACATAAGCAGCTCTATGACCAATAGCACAGCTGCCA
GTAGACCCCCGGTCACCCTGAGGCTGGTGGTCCCTGCTAGTCAGTGTGGCTCTCTCATTGGAAAAGGTGGATGCAAGATCAAGGAAATAC
GAGAGAGTACAGGGGCTCAGGTCCAGGTGGCAGGGGATATGCTACCCAACTCAACTGAGCGGGCCATCACTATTGCTGGCATTCCACAAT
CCATCATTGAGTGTGTCAAACAGATCTGCGTGGTCATGTTGGAGTCCCCCCCGAAGGGCGTGACCATCCCGTACCGGCCCAAGCCGTCCA
GCTCTCCGGTCATCTTTGCAGGTGGTCAGGCCTATACCATTCAAGGACAGTATGCCATTCCACAGCCAGATTTGACCAAGCTGCACCAGT
TGGCAATGCAACAGTCTCATTTTCCCATGACGCATGGCAACACCGGATTCAGTGGCATTGAATCCAGCTCTCCAGAGGTGAAAGGCTATT
GGGCAGGTTTGGATGCATCTGCTCAGACTACTTCTCATGAACTCACCATTCCAAACGATTTGATTGGCTGCATAATCGGGCGTCAAGGCG
CCAAAATCAATGAGATCCGTCAGATGTCTGGGGCGCAGATCAAAATTGCGAACCCAGTGGAAGGATCTACTGATAGGCAGGTTACCATCA
CTGGATCTGCTGCCAGCATTAGCCTGGCTCAATATCTAATCAATGTCAGGCTTTCCTCGGAGACGGGTGGCATGGGGAGCAGCTAGAACA
ATGCAGATTCATCCATAATCCCTTTCTGCTGTTCACCACCACCCATGATCCATCTGTGTAGTTTCTGAACAGTCAGCGATTCCAGGTTTT
AAATAGTTTGTAAATTTTCAGTTTCTACACACTTTATCATCCACTCGTGATTTTTTAATTAAAGCGTTTTAATTCCTTTCTCTGTTCAGC
TGTTGATGCTGAGATCCATATTTAGTTTTATAAGCTTCTCCCTGGTTTTTTTTTTTTGGCTCATGAATTTTTCTGTTTGTCATGGAAATG
TAAGAGTGGAATATTAATACATTTCAGTTTAGTTCTGTAATGTCAGGAATTTTTCAAAAAAATTAAAAGATGGACTGGAGCTTTTTCTTT
GTGAATAGAAACTGGATGCCAAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATA
GTGCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTC
TTGACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCG
ATTCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGC
CCTCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCA
TGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCC
TCAAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATA
AGGATGGAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAAC
TGTCCAAGTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGC
TAGACCGAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATA
GCGTCCTTGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGAC
AGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCA
AAGTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGG
AAGATGCGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATT
ATAAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGT
GGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTG
CCATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCAT
TTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGA
TCATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGG
CTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACG
CACTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGG
AGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAA
AGCAACAGATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATGACATTCGTAAGCCTGGAGAATCTGAAGAATGAAGAC
ATTGAGAAAACTATGTAGCAAGATCCACTTCTGTGATTAAGTAAATGGATGTCTCGTGATGCATCTACAGTTATTTATTGTTACATCCTT
TTCCAGACACTGTAGATGCTATAATAAAAATAGCTGTTTGGTAACCATAGTTTCACTTGTTCAAAGCTGTGTAATCGTGGGGGTACCATC
TCAACTGCTTTTGTATTCATTGTATTAAAAGAATCTGTTTAAACAACCTTTATCTTCTCTTCGGGTTTAAGAAACGTTTATTGTAACAGT
AATTAAATGCTGCCTTAATTGAAGGGGTTTGGGTGGATTTTTTTTTCTCAAAATAAGCTGTAGGGACTATTTTAACAGCTTAAACAGGAG
CTCTCAAGATGCACTTTCATATTGAGAGGAATATGGGCTTGATCCTCTTCCTATCTAAATGGGTGGGCCATTTGATTGTAGAGGGTCCAC
CACAGAATTATGGGATGCCTTAAGTGCTGTTACTAGGTTGCTCACAGCCTAACCTGGCGTGTTGTTTAGGGCTGATGGAGACCCATGTGA
GCCTTTGCTTTCCTCTGGCCCCGGCCCCACCCTGAACACAGCTCATACACAGAATCAGGACCAGCATGTGCAGAGCTGGCCACCAGCACA
GGCTTAGGGCAGTTCAGAACCCACTTGTTTCCCTATCAGAGGGACACAGTGAAGTGGAGGTTAAAGTAAATTACAGGAAATAAGGGAGAA
ATCTTGCAGTTACCATGTTCAGATAGAGTGACTGAAATTAATTGTACTTACTAAAGTATTAACTAGCTAACAGTGATGGGCCAAGACGCT
CCGAGAACTCTACCGGGATTGTCTGTTCTGACAACCCAGTGAGGCAGATACACTTTCTTACTGCTCACATCTTACAGGTGAGTACTCATA
ATTGGCCAGCATCTCACCACCAGCAAGTAGTAGGGCCAGGTCAATCCCAGGCAGTCTGACCCCAGAGTGGCCCAGCTCATCCCCTACTCT
GTTATTTGCTTGTTAATGATTCTCTAGATTTTCTAAAATAATGTTTCTTAGCATTGTGATGATAAAGCTCATGATGAACTTTATCACTAG
TTATGCCACCTTAACTAGTCAGATTTCCTAGAATTAGGAAATGGTGACTCTTGTCTAAATTTGGTTAAGTGATGAATTTGGGTTACCGTC
TCATGTGAACCTGGAGATTCACCAGTCTTAACTTTTGGGTCATTGTGTTTTCTCTACATTCATGCATTGGATGTTTTGCTAAATAACTCC
TGTGGATTTAGGAATGTGTGCTAATAGCAATCTTCCTAATTTTCATGTTTATATGGAACTATGCAGTTGAGTATTGAAAGCTTTAAACTG
AGTTTATTTACAAGGACTGAGTCTAGCCTACAGAGAACATACAGCAGCCTTCTTTGGACCACAGTCTTATCCGAGGGGTCTGTGGTTGTA
TCAGAAGAGCCACTAAACCAATCCCCCTTTCCAAAATTGAACCTCACAGACGTTCCTGTTTTTTGTGATTGAGAAACTGGTCAATGAACA
GGAAGACTTAGAGATGTTTCACAAGCCTTTGATTTTTGTTTCATTTATTTGTAATAAACCTCTTCCACGTGATGTCTTTTATTTTTCACG

>63102_63102_1_PCBP2-CCT5_PCBP2_chr12_53873616_ENST00000359282_CCT5_chr5_10250033_ENST00000280326_length(amino acids)=551AA_BP=
MGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM
MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAK
TTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKP
KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTA
EKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC
PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKI

--------------------------------------------------------------
>63102_63102_2_PCBP2-CCT5_PCBP2_chr12_53873616_ENST00000359462_CCT5_chr5_10250033_ENST00000280326_length(transcript)=5489nt_BP=1814nt
GCAGCCGCAGCCTGCGCCCTCTCCCGCCCGCCCGCCCTCCGCCCGCCCGCCCGCCCTCCGCCGCCCTCCACCCGCCCCGGGGTCTCTTTC
CCCCTTCCTCCTCCTCCTCCTCCACCCCCCCTTCCTCCTCCGCCCGCCCGCGGGGCCCCCCTCGCCTTCCCGCCCGCCCCTATTGTTCCG
CCCCCGGCCTCCCGCCCTTCCCCTTCCCGCCCGCTCCCCTTTTCCCCTCAGTCGCCTCGCGCCTGCAGTTTTTGGCTTTCACCCCCAACC
AGTGACCAAAGACTTGACCACTCAAAGTCCAGCTCCCCAGAACACTGCTCGACATGGACACCGGTGTGATTGAAGGTGGATTAAATGTCA
CTCTCACCATCCGGCTACTTATGCATGGAAAGGAAGTTGGCAGTATCATCGGAAAGAAAGGAGAATCAGTTAAGAAGATGCGCGAGGAGA
GTGGTGCACGTATCAACATCTCAGAAGGGAATTGTCCTGAGAGAATTATCACTTTGGCTGGACCCACTAATGCCATCTTCAAAGCCTTTG
CTATGATCATTGACAAACTGGAAGAGGACATAAGCAGCTCTATGACCAATAGCACAGCTGCCAGTAGACCCCCGGTCACCCTGAGGCTGG
TGGTCCCTGCTAGTCAGTGTGGCTCTCTCATTGGAAAAGGTGGATGCAAGATCAAGGAAATACGAGAGAGTACAGGGGCTCAGGTCCAGG
TGGCAGGGGATATGCTACCCAACTCAACTGAGCGGGCCATCACTATTGCTGGCATTCCACAATCCATCATTGAGTGTGTCAAACAGATCT
GCGTGGTCATGTTGGAGACTCTCTCCCAGTCCCCCCCGAAGGGCGTGACCATCCCGTACCGGCCCAAGCCGTCCAGCTCTCCGGTCATCT
TTGCAGGTGGTCAGGACAGGTACAGCACAGGCAGCGACAGTGCGAGCTTTCCCCACACCACCCCGTCCATGTGCCTCAACCCTGACCTGG
AGGGACCACCTCTAGAGGCCTATACCATTCAAGGACAGTATGCCATTCCACAGCCAGATTTGACCAAGCTGCACCAGTTGGCAATGCAAC
AGTCTCATTTTCCCATGACGCATGGCAACACCGGATTCAGTGGCATTGAATCCAGCTCTCCAGAGGTGAAAGGCTATTGGGCAGGTTTGG
ATGCATCTGCTCAGACTACTTCTCATGAACTCACCATTCCAAACGATTTGATTGGCTGCATAATCGGGCGTCAAGGCGCCAAAATCAATG
AGATCCGTCAGATGTCTGGGGCGCAGATCAAAATTGCGAACCCAGTGGAAGGATCTACTGATAGGCAGGTTACCATCACTGGATCTGCTG
CCAGCATTAGCCTGGCTCAATATCTAATCAATGTCAGGCTTTCCTCGGAGACGGGTGGCATGGGGAGCAGCTAGAACAATGCAGATTCAT
CCATAATCCCTTTCTGCTGTTCACCACCACCCATGATCCATCTGTGTAGTTTCTGAACAGTCAGCGATTCCAGGTTTTAAATAGTTTGTA
AATTTTCAGTTTCTACACACTTTATCATCCACTCGTGATTTTTTAATTAAAGCGTTTTAATTCCTTTCTCTGTTCAGCTGTTGATGCTGA
GATCCATATTTAGTTTTATAAGCTTCTCCCTGGTTTTTTTTTTTTGGCTCATGAATTTTTCTGTTTGTCATGGAAATGTAAGAGTGGAAT
ATTAATACATTTCAGTTTAGTTCTGTAATGTCAGGAATTTTTCAAAAAAATTAAAAGATGGACTGGAGCTTTTTCTTTGTGAATAGAAAC
TGGATGCCACAGTGAAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTT
TAAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACT
TGTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCA
GAAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCC
GAGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGA
CCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGT
CTCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAGGATG
GAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCA
AGTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACC
GAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCC
TTGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGG
CTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGG
GCGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATG
CGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAG
CCCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCT
TTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCG
CAACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGA
CAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATCATTG
AGGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTG
AGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGG
AGGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGA
ACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAAC
AGATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATGACATTCGTAAGCCTGGAGAATCTGAAGAATGAAGACATTGAG
AAAACTATGTAGCAAGATCCACTTCTGTGATTAAGTAAATGGATGTCTCGTGATGCATCTACAGTTATTTATTGTTACATCCTTTTCCAG
ACACTGTAGATGCTATAATAAAAATAGCTGTTTGGTAACCATAGTTTCACTTGTTCAAAGCTGTGTAATCGTGGGGGTACCATCTCAACT
GCTTTTGTATTCATTGTATTAAAAGAATCTGTTTAAACAACCTTTATCTTCTCTTCGGGTTTAAGAAACGTTTATTGTAACAGTAATTAA
ATGCTGCCTTAATTGAAGGGGTTTGGGTGGATTTTTTTTTCTCAAAATAAGCTGTAGGGACTATTTTAACAGCTTAAACAGGAGCTCTCA
AGATGCACTTTCATATTGAGAGGAATATGGGCTTGATCCTCTTCCTATCTAAATGGGTGGGCCATTTGATTGTAGAGGGTCCACCACAGA
ATTATGGGATGCCTTAAGTGCTGTTACTAGGTTGCTCACAGCCTAACCTGGCGTGTTGTTTAGGGCTGATGGAGACCCATGTGAGCCTTT
GCTTTCCTCTGGCCCCGGCCCCACCCTGAACACAGCTCATACACAGAATCAGGACCAGCATGTGCAGAGCTGGCCACCAGCACAGGCTTA
GGGCAGTTCAGAACCCACTTGTTTCCCTATCAGAGGGACACAGTGAAGTGGAGGTTAAAGTAAATTACAGGAAATAAGGGAGAAATCTTG
CAGTTACCATGTTCAGATAGAGTGACTGAAATTAATTGTACTTACTAAAGTATTAACTAGCTAACAGTGATGGGCCAAGACGCTCCGAGA
ACTCTACCGGGATTGTCTGTTCTGACAACCCAGTGAGGCAGATACACTTTCTTACTGCTCACATCTTACAGGTGAGTACTCATAATTGGC
CAGCATCTCACCACCAGCAAGTAGTAGGGCCAGGTCAATCCCAGGCAGTCTGACCCCAGAGTGGCCCAGCTCATCCCCTACTCTGTTATT
TGCTTGTTAATGATTCTCTAGATTTTCTAAAATAATGTTTCTTAGCATTGTGATGATAAAGCTCATGATGAACTTTATCACTAGTTATGC
CACCTTAACTAGTCAGATTTCCTAGAATTAGGAAATGGTGACTCTTGTCTAAATTTGGTTAAGTGATGAATTTGGGTTACCGTCTCATGT
GAACCTGGAGATTCACCAGTCTTAACTTTTGGGTCATTGTGTTTTCTCTACATTCATGCATTGGATGTTTTGCTAAATAACTCCTGTGGA
TTTAGGAATGTGTGCTAATAGCAATCTTCCTAATTTTCATGTTTATATGGAACTATGCAGTTGAGTATTGAAAGCTTTAAACTGAGTTTA
TTTACAAGGACTGAGTCTAGCCTACAGAGAACATACAGCAGCCTTCTTTGGACCACAGTCTTATCCGAGGGGTCTGTGGTTGTATCAGAA
GAGCCACTAAACCAATCCCCCTTTCCAAAATTGAACCTCACAGACGTTCCTGTTTTTTGTGATTGAGAAACTGGTCAATGAACAGGAAGA

>63102_63102_2_PCBP2-CCT5_PCBP2_chr12_53873616_ENST00000359462_CCT5_chr5_10250033_ENST00000280326_length(amino acids)=551AA_BP=
MGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM
MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAK
TTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKP
KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTA
EKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC
PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PCBP2-CCT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PCBP2-CCT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PCBP2-CCT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource