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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PCCA-GRM3 (FusionGDB2 ID:63154)

Fusion Gene Summary for PCCA-GRM3

check button Fusion gene summary
Fusion gene informationFusion gene name: PCCA-GRM3
Fusion gene ID: 63154
HgeneTgene
Gene symbol

PCCA

GRM3

Gene ID

5095

2913

Gene namepropionyl-CoA carboxylase subunit alphaglutamate metabotropic receptor 3
Synonyms-GLUR3|GPRC1C|MGLUR3|mGlu3
Cytomap

13q32.3

7q21.11-q21.12

Type of geneprotein-codingprotein-coding
Descriptionpropionyl-CoA carboxylase alpha chain, mitochondrialPCCase alpha subunitpccA complementation grouppropanoyl-CoA:carbon dioxide ligase alpha subunitpropionyl CoA carboxylase, alpha polypeptidepropionyl Coenzyme A carboxylase, alpha polypeptidepropionmetabotropic glutamate receptor 3glutamate receptor, metabotropic 3
Modification date2020031320200313
UniProtAcc.

Q14832

Ensembl transtripts involved in fusion geneENST00000376285, ENST00000376286, 
ENST00000376279, ENST00000485946, 
ENST00000394720, ENST00000439827, 
ENST00000536043, ENST00000546348, 
ENST00000361669, 
Fusion gene scores* DoF score20 X 16 X 12=38406 X 6 X 3=108
# samples 256
** MAII scorelog2(25/3840*10)=-3.94110631094643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCCA [Title/Abstract] AND GRM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPCCA(101167821)-GRM3(86415576), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PCCA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-SI-A71OPCCAchr13

101167821

+GRM3chr7

86415576

+


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Fusion Gene ORF analysis for PCCA-GRM3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000376285ENST00000394720PCCAchr13

101167821

+GRM3chr7

86415576

+
5CDS-intronENST00000376285ENST00000439827PCCAchr13

101167821

+GRM3chr7

86415576

+
5CDS-intronENST00000376285ENST00000536043PCCAchr13

101167821

+GRM3chr7

86415576

+
5CDS-intronENST00000376285ENST00000546348PCCAchr13

101167821

+GRM3chr7

86415576

+
5CDS-intronENST00000376286ENST00000394720PCCAchr13

101167821

+GRM3chr7

86415576

+
5CDS-intronENST00000376286ENST00000439827PCCAchr13

101167821

+GRM3chr7

86415576

+
5CDS-intronENST00000376286ENST00000536043PCCAchr13

101167821

+GRM3chr7

86415576

+
5CDS-intronENST00000376286ENST00000546348PCCAchr13

101167821

+GRM3chr7

86415576

+
In-frameENST00000376285ENST00000361669PCCAchr13

101167821

+GRM3chr7

86415576

+
In-frameENST00000376286ENST00000361669PCCAchr13

101167821

+GRM3chr7

86415576

+
intron-3CDSENST00000376279ENST00000361669PCCAchr13

101167821

+GRM3chr7

86415576

+
intron-3CDSENST00000485946ENST00000361669PCCAchr13

101167821

+GRM3chr7

86415576

+
intron-intronENST00000376279ENST00000394720PCCAchr13

101167821

+GRM3chr7

86415576

+
intron-intronENST00000376279ENST00000439827PCCAchr13

101167821

+GRM3chr7

86415576

+
intron-intronENST00000376279ENST00000536043PCCAchr13

101167821

+GRM3chr7

86415576

+
intron-intronENST00000376279ENST00000546348PCCAchr13

101167821

+GRM3chr7

86415576

+
intron-intronENST00000485946ENST00000394720PCCAchr13

101167821

+GRM3chr7

86415576

+
intron-intronENST00000485946ENST00000439827PCCAchr13

101167821

+GRM3chr7

86415576

+
intron-intronENST00000485946ENST00000536043PCCAchr13

101167821

+GRM3chr7

86415576

+
intron-intronENST00000485946ENST00000546348PCCAchr13

101167821

+GRM3chr7

86415576

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376286PCCAchr13101167821+ENST00000361669GRM3chr786415576+476920686442391391
ENST00000376285PCCAchr13101167821+ENST00000361669GRM3chr786415576+477920783842491403

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376286ENST00000361669PCCAchr13101167821+GRM3chr786415576+0.0004606480.9995394
ENST00000376285ENST00000361669PCCAchr13101167821+GRM3chr786415576+0.0003511250.9996489

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Fusion Genomic Features for PCCA-GRM3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PCCAchr13101167821+GRM3chr786415576+0.001497310.99850273
PCCAchr13101167821+GRM3chr786415576+0.001497310.99850273

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PCCA-GRM3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:101167821/chr7:86415576)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GRM3

Q14832

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:8840013}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCCAchr13:101167821chr7:86415576ENST00000376285+2224181_378680729.0DomainATP-grasp
HgenePCCAchr13:101167821chr7:86415576ENST00000376285+222462_509680729.0DomainBiotin carboxylation
HgenePCCAchr13:101167821chr7:86415576ENST00000376286+2123181_378654703.0DomainATP-grasp
HgenePCCAchr13:101167821chr7:86415576ENST00000376286+212362_509654703.0DomainBiotin carboxylation
HgenePCCAchr13:101167821chr7:86415576ENST00000376285+2224209_270680729.0Nucleotide bindingATP
HgenePCCAchr13:101167821chr7:86415576ENST00000376286+2123209_270654703.0Nucleotide bindingATP
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916172_174156880.0RegionGlutamate binding
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015172_174154536.0RegionGlutamate binding
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715172_174156538.0RegionGlutamate binding
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916600_613156880.0Topological domainCytoplasmic
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916635_645156880.0Topological domainExtracellular
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916665_688156880.0Topological domainCytoplasmic
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916710_734156880.0Topological domainExtracellular
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916757_769156880.0Topological domainCytoplasmic
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916793_802156880.0Topological domainExtracellular
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916829_879156880.0Topological domainCytoplasmic
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015600_613154536.0Topological domainCytoplasmic
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015635_645154536.0Topological domainExtracellular
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015665_688154536.0Topological domainCytoplasmic
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015710_734154536.0Topological domainExtracellular
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015757_769154536.0Topological domainCytoplasmic
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015793_802154536.0Topological domainExtracellular
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015829_879154536.0Topological domainCytoplasmic
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715600_613156538.0Topological domainCytoplasmic
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715635_645156538.0Topological domainExtracellular
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715665_688156538.0Topological domainCytoplasmic
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715710_734156538.0Topological domainExtracellular
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715757_769156538.0Topological domainCytoplasmic
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715793_802156538.0Topological domainExtracellular
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715829_879156538.0Topological domainCytoplasmic
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916577_599156880.0TransmembraneHelical%3B Name%3D1
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916614_634156880.0TransmembraneHelical%3B Name%3D2
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916646_664156880.0TransmembraneHelical%3B Name%3D3
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916689_709156880.0TransmembraneHelical%3B Name%3D4
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916735_756156880.0TransmembraneHelical%3B Name%3D5
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916770_792156880.0TransmembraneHelical%3B Name%3D6
TgeneGRM3chr13:101167821chr7:86415576ENST0000036166916803_828156880.0TransmembraneHelical%3B Name%3D7
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015577_599154536.0TransmembraneHelical%3B Name%3D1
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015614_634154536.0TransmembraneHelical%3B Name%3D2
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015646_664154536.0TransmembraneHelical%3B Name%3D3
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015689_709154536.0TransmembraneHelical%3B Name%3D4
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015735_756154536.0TransmembraneHelical%3B Name%3D5
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015770_792154536.0TransmembraneHelical%3B Name%3D6
TgeneGRM3chr13:101167821chr7:86415576ENST0000039472015803_828154536.0TransmembraneHelical%3B Name%3D7
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715577_599156538.0TransmembraneHelical%3B Name%3D1
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715614_634156538.0TransmembraneHelical%3B Name%3D2
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715646_664156538.0TransmembraneHelical%3B Name%3D3
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715689_709156538.0TransmembraneHelical%3B Name%3D4
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715735_756156538.0TransmembraneHelical%3B Name%3D5
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715770_792156538.0TransmembraneHelical%3B Name%3D6
TgeneGRM3chr13:101167821chr7:86415576ENST0000043982715803_828156538.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCCAchr13:101167821chr7:86415576ENST00000376279+123181_3780682.0DomainATP-grasp
HgenePCCAchr13:101167821chr7:86415576ENST00000376279+12362_5090682.0DomainBiotin carboxylation
HgenePCCAchr13:101167821chr7:86415576ENST00000376279+123653_7280682.0DomainBiotinyl-binding
HgenePCCAchr13:101167821chr7:86415576ENST00000376285+2224653_728680729.0DomainBiotinyl-binding
HgenePCCAchr13:101167821chr7:86415576ENST00000376286+2123653_728654703.0DomainBiotinyl-binding
HgenePCCAchr13:101167821chr7:86415576ENST00000376279+123209_2700682.0Nucleotide bindingATP
TgeneGRM3chr13:101167821chr7:86415576ENST000003616691623_576156880.0Topological domainExtracellular
TgeneGRM3chr13:101167821chr7:86415576ENST000003947201523_576154536.0Topological domainExtracellular
TgeneGRM3chr13:101167821chr7:86415576ENST000004398271523_576156538.0Topological domainExtracellular


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Fusion Gene Sequence for PCCA-GRM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63154_63154_1_PCCA-GRM3_PCCA_chr13_101167821_ENST00000376285_GRM3_chr7_86415576_ENST00000361669_length(transcript)=4779nt_BP=2078nt
GTGAGAGGTCAGCAGAGGGGCGGTCTGCGGGGACAACAATGGCGGGGTTCTGGGTCGGGACAGCACCGCTGGTCGCTGCCGGACGGCGTG
GGCGGTGGCCGCCGCAGCAGCTGATGCTGAGCGCGGCGCTGCGGACCCTGAAGCATGTTCTGTACTATTCAAGACAGTGCTTAATGGTGT
CCCGTAATCTTGGTTCAGTGGGATATGATCCTAATGAAAAAACTTTTGATAAAATTCTTGTTGCTAATAGAGGAGAAATTGCATGTCGGG
TTATTAGAACTTGCAAGAAGATGGGCATTAAGACAGTTGCCATCCACAGTGATGTTGATGCTAGTTCTGTTCATGTGAAAATGGCGGATG
AGGCTGTCTGTGTTGGCCCAGCTCCCACCAGTAAAAGCTACCTCAACATGGATGCCATCATGGAAGCCATTAAGAAAACCAGGGCCCAAG
CTGTACATCCAGGTTATGGATTCCTTTCAGAAAACAAAGAATTTGCCAGATGTTTGGCAGCAGAAGATGTCGTTTTCATTGGACCTGACA
CACATGCTATTCAAGCCATGGGCGACAAGATTGAAAGCAAATTATTAGCTAAGAAAGCAGAGGTTAATACAATCCCTGGCTTTGATGGAG
TAGTCAAGGATGCAGAAGAAGCTGTCAGAATTGCAAGGGAAATTGGCTACCCTGTCATGATCAAGGCCTCAGCAGGTGGTGGTGGGAAAG
GCATGCGCATTGCTTGGGATGATGAAGAGACCAGGGATGGTTTTAGATTGTCATCTCAAGAAGCTGCTTCTAGTTTTGGCGATGATAGAC
TACTAATAGAAAAATTTATTGATAATCCTCGTCATATAGAAATCCAGGTTCTAGGTGATAAACATGGGAATGCTTTATGGCTTAATGAAA
GAGAGTGCTCAATTCAGAGAAGAAATCAGAAGGTGGTGGAGGAAGCACCAAGCATTTTTTTGGATGCGGAGACTCGAAGAGCGATGGGAG
AACAAGCTGTAGCTCTTGCCAGAGCAGTAAAATATTCCTCTGCTGGGACCGTGGAGTTCCTTGTGGACTCTAAGAAGAATTTTTATTTCT
TGGAAATGAATACAAGACTCCAGGTTGAGCATCCTGTCACAGAATGCATTACTGGCCTGGACCTAGTCCAGGAAATGATCCGTGTTGCTA
AGGGCTACCCTCTCAGGCACAAACAAGCTGATATTCGCATCAACGGCTGGGCAGTTGAATGTCGGGTTTATGCTGAGGACCCCTACAAGT
CTTTTGGTTTACCATCTATTGGGAGATTGTCTCAGTACCAAGAACCGTTACATCTACCTGGTGTCCGAGTGGACAGTGGCATCCAACCAG
GAAGTGATATTAGCATTTATTATGATCCTATGATTTCAAAACTAATCACATATGGCTCTGATAGAACTGAGGCACTGAAGAGAATGGCAG
ATGCACTGGATAACTATGTTATTCGAGGTGTTACACATAATATTGCATTACTTCGAGAGGTGATAATCAACTCACGCTTTGTAAAAGGAG
ACATCAGCACTAAATTTCTCTCCGATGTGTATCCTGATGGCTTCAAAGGACACATGCTAACCAAGAGTGAGAAGAACCAGTTATTGGCAA
TAGCATCATCATTGTTTGTGGCATTCCAGTTAAGAGCACAACATTTTCAAGAAAATTCAAGAATGCCTGTTATTAAACCAGACATAGCCA
ACTGGGAGCTCTCAGTAAAATTGCATGATAAAGTTCATACCGTAGTAGCATCAAACAATGGGTCAGTGTTCTCGGTGGAAGTTGATGGGT
CGAAACTAAATGTGACCAGCACGTGGAACCTGGCTTCGCCCTTATTGTCTGTCAGCGTTGATGGCACTCAGAGGACTGTCCAGTGTCTTT
CTCGAGAAGCAGGTGGAAACATGAGCATTCAGTTTCTTGGTACAGTGTACAAGGTGAATATCTTAACCAGACTTGCCGCAGAATTGAACA
AATTTATGCTGGAAAAAGTGACTGAGGACACAAGCAGTGTTCTGCGTTCCCCGATGCCCGGAGTGGTGGTGGCCGTCTCTGTCAAGCCTG
GAGACGCGGTGGCAAACCTGCTGCGGCTCTTCCAGATCCCTCAGATCAGCTACGCATCCACCAGCGCCAAACTCAGTGATAAGTCGCGCT
ATGATTACTTTGCCAGGACCGTGCCCCCCGACTTCTACCAGGCCAAAGCCATGGCTGAGATCTTGCGCTTCTTCAACTGGACCTACGTGT
CCACAGTAGCCTCCGAGGGTGATTACGGGGAGACAGGGATCGAGGCCTTCGAGCAGGAAGCCCGCCTGCGCAACATCTGCATCGCTACGG
CGGAGAAGGTGGGCCGCTCCAACATCCGCAAGTCCTACGACAGCGTGATCCGAGAACTGTTGCAGAAGCCCAACGCGCGCGTCGTGGTCC
TCTTCATGCGCAGCGACGACTCGCGGGAGCTCATTGCAGCCGCCAGCCGCGCCAATGCCTCCTTCACCTGGGTGGCCAGCGACGGCTGGG
GCGCGCAGGAGAGCATCATCAAGGGCAGCGAGCATGTGGCCTACGGCGCCATCACCCTGGAGCTGGCCTCCCAGCCTGTCCGCCAGTTCG
ACCGCTACTTCCAGAGCCTCAACCCCTACAACAACCACCGCAACCCCTGGTTCCGGGACTTCTGGGAGCAAAAGTTTCAGTGCAGCCTCC
AGAACAAACGCAACCACAGGCGCGTCTGCGACAAGCACCTGGCCATCGACAGCAGCAACTACGAGCAAGAGTCCAAGATCATGTTTGTGG
TGAACGCGGTGTATGCCATGGCCCACGCTTTGCACAAAATGCAGCGCACCCTCTGTCCCAACACTACCAAGCTTTGTGATGCTATGAAGA
TCCTGGATGGGAAGAAGTTGTACAAGGATTACTTGCTGAAAATCAACTTCACGGCTCCATTCAACCCAAATAAAGATGCAGATAGCATAG
TCAAGTTTGACACTTTTGGAGATGGAATGGGGCGATACAACGTGTTCAATTTCCAAAATGTAGGTGGAAAGTATTCCTACTTGAAAGTTG
GTCACTGGGCAGAAACCTTATCGCTAGATGTCAACTCTATCCACTGGTCCCGGAACTCAGTCCCCACTTCCCAGTGCAGCGACCCCTGTG
CCCCCAATGAAATGAAGAATATGCAACCAGGGGATGTCTGCTGCTGGATTTGCATCCCCTGTGAACCCTACGAATACCTGGCTGATGAGT
TTACCTGTATGGATTGTGGGTCTGGACAGTGGCCCACTGCAGACCTAACTGGATGCTATGACCTTCCTGAGGACTACATCAGGTGGGAAG
ACGCCTGGGCCATTGGCCCAGTCACCATTGCCTGTCTGGGTTTTATGTGTACATGCATGGTTGTAACTGTTTTTATCAAGCACAACAACA
CACCCTTGGTCAAAGCATCGGGCCGAGAACTCTGCTACATCTTATTGTTTGGGGTTGGCCTGTCATACTGCATGACATTCTTCTTCATTG
CCAAGCCATCACCAGTCATCTGTGCATTGCGCCGACTCGGGCTGGGGAGTTCCTTCGCTATCTGTTACTCAGCCCTGCTGACCAAGACAA
ACTGCATTGCCCGCATCTTCGATGGGGTCAAGAATGGCGCTCAGAGGCCAAAATTCATCAGCCCCAGTTCTCAGGTTTTCATCTGCCTGG
GTCTGATCCTGGTGCAAATTGTGATGGTGTCTGTGTGGCTCATCCTGGAGGCCCCAGGCACCAGGAGGTATACCCTTGCAGAGAAGCGGG
AAACAGTCATCCTAAAATGCAATGTCAAAGATTCCAGCATGTTGATCTCTCTTACCTACGATGTGATCCTGGTGATCTTATGCACTGTGT
ACGCCTTCAAAACGCGGAAGTGCCCAGAAAATTTCAACGAAGCTAAGTTCATAGGTTTTACCATGTACACCACGTGCATCATCTGGTTGG
CCTTCCTCCCTATATTTTATGTGACATCAAGTGACTACAGAGTGCAGACGACAACCATGTGCATCTCTGTCAGCCTGAGTGGCTTTGTGG
TCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACACAGACTGCACCTCAACAGGT
TCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAATGGGCGGGAAGTCCTCGACT
CCACCACCTCATCTCTGTGATTGTGAATTGCAGTTCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTGCTCACGTGCAGCTCCAGAAT
ATGGAAACAGAGCAAAAGAACAACCCTAGTACCTTTTTTTAGAAACAGTACGATAAATTATTTTTGAGGACTGTATATAGTGATGTGCTA
GAACTTTCTAGGCTGAGTCTAGTGCCCCTATTATTAACAATTCCCCCAGAACATGGAAATAACCATTGTTTACAGAGCTGAGCATTGGTG
ACAGGGTCTGACATGGTCAGTCTACTAAAAAACAAAAAAAAAAAACAAAAAAAAAAAAACAAAAGAAAAAAATAAAAATACGGTGGCAAT
ATTATGTAACCTTTTTTCCTATGAAGTTTTTTGTAGGTCCTTGTTGTAACTAATTTAGGATGAGTTTCTATGTTGTATATTAAAGTTACA
TTATGTGTAACAGATTGATTTTCTCAGCACAAAATAAAAAGCATCTGTATTAATGTAAAGATACTGAGAATAAAACCTTCAAGGTTTTCC

>63154_63154_1_PCCA-GRM3_PCCA_chr13_101167821_ENST00000376285_GRM3_chr7_86415576_ENST00000361669_length(amino acids)=1403AA_BP=680
MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLKHVLYYSRQCLMVSRNLGSVGYDPNEKTFDKILVANRGEIACRVIRTCKKMGIKTV
AIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIES
KLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKFIDNPRHI
EIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPV
TECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSDISIYYDPMIS
KLITYGSDRTEALKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRA
QHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFL
GTVYKVNILTRLAAELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFY
QAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIA
AASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKH
LAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRY
NVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPT
ADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRL
GLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSS
MLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHII

--------------------------------------------------------------
>63154_63154_2_PCCA-GRM3_PCCA_chr13_101167821_ENST00000376286_GRM3_chr7_86415576_ENST00000361669_length(transcript)=4769nt_BP=2068nt
GGCATCGGGTTTCTGGCTCGTGATTTGCCGGAGCTCCTGCGCTCCCCTTCTCCACCCCCTCCGGCTGTGTGAGAGGTCAGCAGAGGGGCG
GTCTGCGGGGACAACAATGGCGGGGTTCTGGGTCGGGACAGCACCGCTGGTCGCTGCCGGACGGCGTGGGCGGTGGCCGCCGCAGCAGCT
GATGCTGAGCGCGGCGCTGCGGACCCTGAAGACTTTTGATAAAATTCTTGTTGCTAATAGAGGAGAAATTGCATGTCGGGTTATTAGAAC
TTGCAAGAAGATGGGCATTAAGACAGTTGCCATCCACAGTGATGTTGATGCTAGTTCTGTTCATGTGAAAATGGCGGATGAGGCTGTCTG
TGTTGGCCCAGCTCCCACCAGTAAAAGCTACCTCAACATGGATGCCATCATGGAAGCCATTAAGAAAACCAGGGCCCAAGCTGTACATCC
AGGTTATGGATTCCTTTCAGAAAACAAAGAATTTGCCAGATGTTTGGCAGCAGAAGATGTCGTTTTCATTGGACCTGACACACATGCTAT
TCAAGCCATGGGCGACAAGATTGAAAGCAAATTATTAGCTAAGAAAGCAGAGGTTAATACAATCCCTGGCTTTGATGGAGTAGTCAAGGA
TGCAGAAGAAGCTGTCAGAATTGCAAGGGAAATTGGCTACCCTGTCATGATCAAGGCCTCAGCAGGTGGTGGTGGGAAAGGCATGCGCAT
TGCTTGGGATGATGAAGAGACCAGGGATGGTTTTAGATTGTCATCTCAAGAAGCTGCTTCTAGTTTTGGCGATGATAGACTACTAATAGA
AAAATTTATTGATAATCCTCGTCATATAGAAATCCAGGTTCTAGGTGATAAACATGGGAATGCTTTATGGCTTAATGAAAGAGAGTGCTC
AATTCAGAGAAGAAATCAGAAGGTGGTGGAGGAAGCACCAAGCATTTTTTTGGATGCGGAGACTCGAAGAGCGATGGGAGAACAAGCTGT
AGCTCTTGCCAGAGCAGTAAAATATTCCTCTGCTGGGACCGTGGAGTTCCTTGTGGACTCTAAGAAGAATTTTTATTTCTTGGAAATGAA
TACAAGACTCCAGGTTGAGCATCCTGTCACAGAATGCATTACTGGCCTGGACCTAGTCCAGGAAATGATCCGTGTTGCTAAGGGCTACCC
TCTCAGGCACAAACAAGCTGATATTCGCATCAACGGCTGGGCAGTTGAATGTCGGGTTTATGCTGAGGACCCCTACAAGTCTTTTGGTTT
ACCATCTATTGGGAGATTGTCTCAGTACCAAGAACCGTTACATCTACCTGGTGTCCGAGTGGACAGTGGCATCCAACCAGGAAGTGATAT
TAGCATTTATTATGATCCTATGATTTCAAAACTAATCACATATGGCTCTGATAGAACTGAGGCACTGAAGAGAATGGCAGATGCACTGGA
TAACTATGTTATTCGAGGTGTTACACATAATATTGCATTACTTCGAGAGGTGATAATCAACTCACGCTTTGTAAAAGGAGACATCAGCAC
TAAATTTCTCTCCGATGTGTATCCTGATGGCTTCAAAGGACACATGCTAACCAAGAGTGAGAAGAACCAGTTATTGGCAATAGCATCATC
ATTGTTTGTGGCATTCCAGTTAAGAGCACAACATTTTCAAGAAAATTCAAGAATGCCTGTTATTAAACCAGACATAGCCAACTGGGAGCT
CTCAGTAAAATTGCATGATAAAGTTCATACCGTAGTAGCATCAAACAATGGGTCAGTGTTCTCGGTGGAAGTTGATGGGTCGAAACTAAA
TGTGACCAGCACGTGGAACCTGGCTTCGCCCTTATTGTCTGTCAGCGTTGATGGCACTCAGAGGACTGTCCAGTGTCTTTCTCGAGAAGC
AGGTGGAAACATGAGCATTCAGTTTCTTGGTACAGTGTACAAGGTGAATATCTTAACCAGACTTGCCGCAGAATTGAACAAATTTATGCT
GGAAAAAGTGACTGAGGACACAAGCAGTGTTCTGCGTTCCCCGATGCCCGGAGTGGTGGTGGCCGTCTCTGTCAAGCCTGGAGACGCGGT
GGCAAACCTGCTGCGGCTCTTCCAGATCCCTCAGATCAGCTACGCATCCACCAGCGCCAAACTCAGTGATAAGTCGCGCTATGATTACTT
TGCCAGGACCGTGCCCCCCGACTTCTACCAGGCCAAAGCCATGGCTGAGATCTTGCGCTTCTTCAACTGGACCTACGTGTCCACAGTAGC
CTCCGAGGGTGATTACGGGGAGACAGGGATCGAGGCCTTCGAGCAGGAAGCCCGCCTGCGCAACATCTGCATCGCTACGGCGGAGAAGGT
GGGCCGCTCCAACATCCGCAAGTCCTACGACAGCGTGATCCGAGAACTGTTGCAGAAGCCCAACGCGCGCGTCGTGGTCCTCTTCATGCG
CAGCGACGACTCGCGGGAGCTCATTGCAGCCGCCAGCCGCGCCAATGCCTCCTTCACCTGGGTGGCCAGCGACGGCTGGGGCGCGCAGGA
GAGCATCATCAAGGGCAGCGAGCATGTGGCCTACGGCGCCATCACCCTGGAGCTGGCCTCCCAGCCTGTCCGCCAGTTCGACCGCTACTT
CCAGAGCCTCAACCCCTACAACAACCACCGCAACCCCTGGTTCCGGGACTTCTGGGAGCAAAAGTTTCAGTGCAGCCTCCAGAACAAACG
CAACCACAGGCGCGTCTGCGACAAGCACCTGGCCATCGACAGCAGCAACTACGAGCAAGAGTCCAAGATCATGTTTGTGGTGAACGCGGT
GTATGCCATGGCCCACGCTTTGCACAAAATGCAGCGCACCCTCTGTCCCAACACTACCAAGCTTTGTGATGCTATGAAGATCCTGGATGG
GAAGAAGTTGTACAAGGATTACTTGCTGAAAATCAACTTCACGGCTCCATTCAACCCAAATAAAGATGCAGATAGCATAGTCAAGTTTGA
CACTTTTGGAGATGGAATGGGGCGATACAACGTGTTCAATTTCCAAAATGTAGGTGGAAAGTATTCCTACTTGAAAGTTGGTCACTGGGC
AGAAACCTTATCGCTAGATGTCAACTCTATCCACTGGTCCCGGAACTCAGTCCCCACTTCCCAGTGCAGCGACCCCTGTGCCCCCAATGA
AATGAAGAATATGCAACCAGGGGATGTCTGCTGCTGGATTTGCATCCCCTGTGAACCCTACGAATACCTGGCTGATGAGTTTACCTGTAT
GGATTGTGGGTCTGGACAGTGGCCCACTGCAGACCTAACTGGATGCTATGACCTTCCTGAGGACTACATCAGGTGGGAAGACGCCTGGGC
CATTGGCCCAGTCACCATTGCCTGTCTGGGTTTTATGTGTACATGCATGGTTGTAACTGTTTTTATCAAGCACAACAACACACCCTTGGT
CAAAGCATCGGGCCGAGAACTCTGCTACATCTTATTGTTTGGGGTTGGCCTGTCATACTGCATGACATTCTTCTTCATTGCCAAGCCATC
ACCAGTCATCTGTGCATTGCGCCGACTCGGGCTGGGGAGTTCCTTCGCTATCTGTTACTCAGCCCTGCTGACCAAGACAAACTGCATTGC
CCGCATCTTCGATGGGGTCAAGAATGGCGCTCAGAGGCCAAAATTCATCAGCCCCAGTTCTCAGGTTTTCATCTGCCTGGGTCTGATCCT
GGTGCAAATTGTGATGGTGTCTGTGTGGCTCATCCTGGAGGCCCCAGGCACCAGGAGGTATACCCTTGCAGAGAAGCGGGAAACAGTCAT
CCTAAAATGCAATGTCAAAGATTCCAGCATGTTGATCTCTCTTACCTACGATGTGATCCTGGTGATCTTATGCACTGTGTACGCCTTCAA
AACGCGGAAGTGCCCAGAAAATTTCAACGAAGCTAAGTTCATAGGTTTTACCATGTACACCACGTGCATCATCTGGTTGGCCTTCCTCCC
TATATTTTATGTGACATCAAGTGACTACAGAGTGCAGACGACAACCATGTGCATCTCTGTCAGCCTGAGTGGCTTTGTGGTCTTGGGCTG
TTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACACAGACTGCACCTCAACAGGTTCAGTGTCAG
TGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAATGGGCGGGAAGTCCTCGACTCCACCACCTC
ATCTCTGTGATTGTGAATTGCAGTTCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTGCTCACGTGCAGCTCCAGAATATGGAAACAG
AGCAAAAGAACAACCCTAGTACCTTTTTTTAGAAACAGTACGATAAATTATTTTTGAGGACTGTATATAGTGATGTGCTAGAACTTTCTA
GGCTGAGTCTAGTGCCCCTATTATTAACAATTCCCCCAGAACATGGAAATAACCATTGTTTACAGAGCTGAGCATTGGTGACAGGGTCTG
ACATGGTCAGTCTACTAAAAAACAAAAAAAAAAAACAAAAAAAAAAAAACAAAAGAAAAAAATAAAAATACGGTGGCAATATTATGTAAC
CTTTTTTCCTATGAAGTTTTTTGTAGGTCCTTGTTGTAACTAATTTAGGATGAGTTTCTATGTTGTATATTAAAGTTACATTATGTGTAA

>63154_63154_2_PCCA-GRM3_PCCA_chr13_101167821_ENST00000376286_GRM3_chr7_86415576_ENST00000361669_length(amino acids)=1391AA_BP=668
MCERSAEGRSAGTTMAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLKTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVH
VKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTI
PGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNA
LWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQE
MIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEA
LKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRAQHFQENSRMPVI
KPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRL
AAELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFF
NWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWV
ASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQES
KIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKY
SYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPED
YIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSA
LLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILV
ILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PCCA-GRM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PCCA-GRM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PCCA-GRM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource