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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PCDHGA4-JMJD1C (FusionGDB2 ID:63253) |
Fusion Gene Summary for PCDHGA4-JMJD1C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PCDHGA4-JMJD1C | Fusion gene ID: 63253 | Hgene | Tgene | Gene symbol | PCDHGA4 | JMJD1C | Gene ID | 56111 | 221037 |
| Gene name | protocadherin gamma subfamily A, 4 | jumonji domain containing 1C | |
| Synonyms | PCDH-GAMMA-A4 | KDM3C|TRIP-8|TRIP8 | |
| Cytomap | 5q31.3 | 10q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protocadherin gamma-A4 | probable JmjC domain-containing histone demethylation protein 2CTR-interacting protein 8thyroid hormone receptor interactor 8thyroid receptor-interacting protein 8 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q15652 | |
| Ensembl transtripts involved in fusion gene | ENST00000571252, | ENST00000399251, ENST00000489372, ENST00000542921, ENST00000402544, ENST00000399262, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 19 X 16 X 5=1520 |
| # samples | 1 | 17 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(17/1520*10)=-3.16046467219325 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PCDHGA4 [Title/Abstract] AND JMJD1C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PCDHGA4(140737188)-JMJD1C(65024524), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across PCDHGA4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across JMJD1C (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-EE-A20I-06A | PCDHGA4 | chr5 | 140737188 | + | JMJD1C | chr10 | 65024524 | - |
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Fusion Gene ORF analysis for PCDHGA4-JMJD1C |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000571252 | ENST00000399251 | PCDHGA4 | chr5 | 140737188 | + | JMJD1C | chr10 | 65024524 | - |
| 5CDS-5UTR | ENST00000571252 | ENST00000489372 | PCDHGA4 | chr5 | 140737188 | + | JMJD1C | chr10 | 65024524 | - |
| 5CDS-5UTR | ENST00000571252 | ENST00000542921 | PCDHGA4 | chr5 | 140737188 | + | JMJD1C | chr10 | 65024524 | - |
| 5CDS-intron | ENST00000571252 | ENST00000402544 | PCDHGA4 | chr5 | 140737188 | + | JMJD1C | chr10 | 65024524 | - |
| In-frame | ENST00000571252 | ENST00000399262 | PCDHGA4 | chr5 | 140737188 | + | JMJD1C | chr10 | 65024524 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000571252 | PCDHGA4 | chr5 | 140737188 | + | ENST00000399262 | JMJD1C | chr10 | 65024524 | - | 10535 | 2421 | 0 | 9710 | 3236 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000571252 | ENST00000399262 | PCDHGA4 | chr5 | 140737188 | + | JMJD1C | chr10 | 65024524 | - | 0.000232052 | 0.99976796 |
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Fusion Genomic Features for PCDHGA4-JMJD1C |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PCDHGA4-JMJD1C |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:140737188/chr10:65024524) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | JMJD1C |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PCDHGA4 | chr5:140737188 | chr10:65024524 | ENST00000571252 | + | 1 | 4 | 165_273 | 807 | 932.0 | Domain | Cadherin 2 |
| Hgene | PCDHGA4 | chr5:140737188 | chr10:65024524 | ENST00000571252 | + | 1 | 4 | 274_378 | 807 | 932.0 | Domain | Cadherin 3 |
| Hgene | PCDHGA4 | chr5:140737188 | chr10:65024524 | ENST00000571252 | + | 1 | 4 | 379_483 | 807 | 932.0 | Domain | Cadherin 4 |
| Hgene | PCDHGA4 | chr5:140737188 | chr10:65024524 | ENST00000571252 | + | 1 | 4 | 484_598 | 807 | 932.0 | Domain | Cadherin 5 |
| Hgene | PCDHGA4 | chr5:140737188 | chr10:65024524 | ENST00000571252 | + | 1 | 4 | 601_713 | 807 | 932.0 | Domain | Cadherin 6 |
| Hgene | PCDHGA4 | chr5:140737188 | chr10:65024524 | ENST00000571252 | + | 1 | 4 | 60_164 | 807 | 932.0 | Domain | Cadherin 1 |
| Hgene | PCDHGA4 | chr5:140737188 | chr10:65024524 | ENST00000571252 | + | 1 | 4 | 60_723 | 807 | 932.0 | Topological domain | Extracellular |
| Hgene | PCDHGA4 | chr5:140737188 | chr10:65024524 | ENST00000571252 | + | 1 | 4 | 724_744 | 807 | 932.0 | Transmembrane | Helical |
| Tgene | JMJD1C | chr5:140737188 | chr10:65024524 | ENST00000399251 | 1 | 25 | 2274_2498 | 0 | 477.0 | Domain | JmjC | |
| Tgene | JMJD1C | chr5:140737188 | chr10:65024524 | ENST00000399262 | 1 | 26 | 2274_2498 | 111 | 2541.0 | Domain | JmjC | |
| Tgene | JMJD1C | chr5:140737188 | chr10:65024524 | ENST00000542921 | 0 | 25 | 2274_2498 | 0 | 2359.0 | Domain | JmjC | |
| Tgene | JMJD1C | chr5:140737188 | chr10:65024524 | ENST00000399251 | 1 | 25 | 2066_2070 | 0 | 477.0 | Motif | Note=LXXLL motif | |
| Tgene | JMJD1C | chr5:140737188 | chr10:65024524 | ENST00000399262 | 1 | 26 | 2066_2070 | 111 | 2541.0 | Motif | Note=LXXLL motif | |
| Tgene | JMJD1C | chr5:140737188 | chr10:65024524 | ENST00000542921 | 0 | 25 | 2066_2070 | 0 | 2359.0 | Motif | Note=LXXLL motif | |
| Tgene | JMJD1C | chr5:140737188 | chr10:65024524 | ENST00000399251 | 1 | 25 | 1846_1871 | 0 | 477.0 | Zinc finger | C6-type | |
| Tgene | JMJD1C | chr5:140737188 | chr10:65024524 | ENST00000399262 | 1 | 26 | 1846_1871 | 111 | 2541.0 | Zinc finger | C6-type | |
| Tgene | JMJD1C | chr5:140737188 | chr10:65024524 | ENST00000542921 | 0 | 25 | 1846_1871 | 0 | 2359.0 | Zinc finger | C6-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PCDHGA4 | chr5:140737188 | chr10:65024524 | ENST00000571252 | + | 1 | 4 | 745_962 | 807 | 932.0 | Topological domain | Cytoplasmic |
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Fusion Gene Sequence for PCDHGA4-JMJD1C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >63253_63253_1_PCDHGA4-JMJD1C_PCDHGA4_chr5_140737188_ENST00000571252_JMJD1C_chr10_65024524_ENST00000399262_length(transcript)=10535nt_BP=2421nt ATGGCGGCGCCTCCTGCTCGCCCAGACCACACCCGGCTGCTCCAGATCTGCCTTCTCCTGGGGGTTCTGGTGGAAATCAGGGCCGAACAG ATTCTCTACTCGGTGTTTGAGGAGCAGGAAGAAGGCTCAGTGGTGGGCAACATCGCCAAGGACCTGGGGTTGGCGCCCCGGGAGCTGGCG GAGCGCGGAGTCCGCATCGTCTCCAGAGGTAGGACGCAGCTTTTCGCCCTGAACCCGCGCAGCGGCACCTTGGTCACCGCGGGTAGGATA GACAGGGAGGAGCTCTGCGACAGATCTCCAAACTGTGTGACAAACCTGGAGATTCTTCTAGAAGATACAGTGAAGATTTTGCGGGTAGAG GTGGAAATAATCGATGTTAATGATAACCCACCCAGTTTTGGGACAGAACAGAGGGAAATAAAAGTTGCTGAAAATGAAAATCCTGGGGCA AGATTTCCTCTTCCTGAAGCTTTTGATCCGGATGTAGGTGTAAACTCCCTGCAGGGTTACCAGCTCAACTCAAACGGTTACTTTTCCCTG GACGTGCAAAGTGGGGCCGATGGGATTAAGTACCCAGAGCTGGTGCTGGAACGCGCTCTAGATCGCGAGGAAGAGGCGGTTCACCACCTC GTTCTCACGGCCTTCGATGGAGGTGACCCGGTTCGCTCTGGCACTGCCAGGATTCTCATAATACTTGTGGATACCAACGATAATGCTCCC GTGTTCACTCAGCCCGAGTACCACGTAAGTGTTCGTGAGAACGTTCCTGTAGGCACTCGGCTACTCACCGTAAAAGCCACTGATCCAGAT GAAGGAGCCAATGGAGACGTGACGTATTCTTTCCGGAAAGTAAGAGACAAAATATCACAGCTATTTCAGTTGAATTCTCTGAGTGGGGAT ATAACAATATTGGGGGGTCTAGATTATGAGGACTCTGGATTCTATGACATAGATGTAGAAGCCCATGATGGGCCTGGTCTCCGAGCTAGA AGCAAGGTACTGGTGACAGTTCTGGATGAAAATGACAACGCACCAGAAGTCACAGTTACATCTCTCACCAGCTCAGTCCAGGAATCTTCT TCCCCGGGTACAGTAATTGCACTTTTCAACGTGCATGACAGTGACTCAGGAGGAAATGGCCTAGTCACATGTTCTATTCCAGATAATCTG CCATTCACACTTGAAAAGACCTATGGAAATTATTATCGGTTGTTGACACACAGAACACTGGACAGGGAAGAAGTCTCAGAATATAACATC ACTGTAACTGCCACTGACCAGGGAACTCCTCCACTGTCTACAGAAACTCATATTTCACTGCAAGTGATGGACATCAATGACAACCCACCC ACTTTCCCTCATGCTTCCTACTCTGCTTACATTCCTGAAAACAACCCCAGAGGAGCCTCCATCTTATCTATGACTGCTCAAGACCCTGAC AGTGGTGACAATGCCCGAATCACTTACTCCCTGGCCGAAGACACCTTCCAGGGTGCACCTCTGTCCTCCTATGTCTCCATCAACTCCAAT ACAGGGATCCTATATGCTCTTTGCTCCTTCGACTATGAGCAGTTTAGAGACCTGCAGCTGCTGATGACAGCCAGTGACAGTGGAGACCCT CCACTCAGCAGCAATGTGTCACTGAGCCTCTTTGTGCTGGACCAGAACGACAATGTCCCTGAGATCCTGTACCCCACCTTCCCTACTGAT GGCTCCACTGGTGTGGAGCTGGCACCCCGCTCCGCAGATTCCGGCTACCTGGTGACCAAAGTGGTGGCAGTGGACAGAGACTCAGGTCAG AATGCCTGGCTGTCCTACAGCCTACTCAAGTCCAGCGAGCCGGGACTATTTGCAGTGGGGCTGCACACAGGCGAGGTGCGCACCGCACGG GCCCTGCTGGACAGAGACGCGCTCAAGCAGAGGCTTGTAGTGGTCGTCCAGGACCATGGCCAGCCCCCTCTCTCGGCCACCGTCACACTC ACTGTGGCTGTGGCCGACAGCATCCCAGATGTCCTGGCTGACTTGGGCAGCCTCAAGCCTTCAGCAGACCCAGACGACTCGGGCCTCACA CTCTATCTCGTGGTGGCAGTGGCCGCTGTCTCCTGCGTCTTCCTGGCTTTTGTCACGGTGCTGCTAGCACTCAAGCTGAGACGCTGGCAC AAGTCACGCCTGCTTCACGCTGAAGGCAGCAGGTTGGCAGGTGTGCCTGCCTCGCACTTTGTGGGCGTGGACGGGGTTCGGGCTTTCCTG CAGACCTATTCCCACGAGGTCTCCCTCACCGCGGACTCGCGGAAGAGTCACCTGATCTTCTCCCAACCCAGCTATGCAGACACGCTCATC AGCCGGGAGAGTTGTGAGAAAAGCGAGCCTCTTCTGATAACTCAGGATTTACTTGAAACAAAAGGAGACCCTAATCTTCAGACTTTCAAA CCTCTGGTTGAAAGAAATATACCCAGTTCAGTCACTGCAGTAGAATTCCTTGTAGATAAGCAACTGGATTTTTTAACTGAAGATAGTGCC TTTCAGCCCTACCAGGACGACATAGACAGCCTAAACCCAGTTCTCAGGGACAACCCGCAGCTTCATGAGGAAGTGAAAGTCTGGGTAAAG GAACAAAAGGTTCAGGAGATTTTTATGCAAGGTCCTTATTCCTTAAATGGATACAGAGTGAGAGTATATAGACAAGACTCTGCCACCCAG TGGTTTACTGGCATAATTACTCATCATGATCTCTTCACCCGCACCATGATCGTTATGAATGATCAGGTACTAGAACCACAGAATGTCGAT CCTTCTATGGTTCAAATGACCTTTCTAGATGATGTTGTTCACTCTTTGTTAAAAGGTGAAAATATTGGCATTACATCACGACGCAGGTCT CGTGCCAATCAAAACGTCAACGCTGTTCACAGCCATTATACACGTGCCCAAGCAAATAGTCCCAGACCAGCAATGAACTCCCAAGCTGCT GTACCAAAACAGAATACACACCAGCAACAGCAACAAAGAAGTATCCGTCCAAATAAGAGGAAGGGCTCAGATAGCAGTATACCAGATGAA GAGAAGATGAAGGAGGAAAAATATGATTATATATCACGAGGAGAAAATCCTAAAGGTAAAAACAAACACTTGATGAATAAAAGAAGGAAA CCTGAGGAGGATGAAAAGAAACTAAATATGAAAAGACTTCGAACTGACAATGTTTCAGACTTTTCTGAGAGCAGTGACTCAGAAAATTCA AATAAGAGAATAATAGATAATTCCTCAGAACAGAAGCCAGAGAATGAATTGAAAAATAAAAATACTTCAAAAATAAATGGAGAAGAAGGA AAACCCCATAATAATGAGAAGGCAGGAGAAGAGACCCTAAAAAATAGCCAGCCTCCCTGGGATCAAATACAGGAAGATAAAAAACATGAA GAAGCAGAGAAGCGGAAGTCTGTTGACACTCAGCTTCAAGAAGATATGATTATTCATTCGTCAGAACAGTCCACAGTTTCTGATCATAAT TCTAATGATTTACTTCCTCAGGAATGCAATATGGATAAAACACATACCATGGAATTGCTACCAAAGGAGAAGTTTGTATCCAGACCACCC ACACCAAAATGTGTTATTGATATTACAAATGACACTAATTTAGAAAAGGTGGCTCAGGAAAACTCAAGTACCTTTGGCCTTCAGACACTT CAGAAAATGGATCCTAATGTTAGTGATTCAAAACACTCTATTGCAAATGCAAAATTCTTGGAAACAGCAAAAAAAGATTCTGACCAGAGC TGGGTCAGTGATGTAGTTAAAGTGGATCTAACCCAATCAAGTGTTACAAATGCTTCTTCAGGAAATGATCACTTGAACATGGAAAAAGAG AAGTATGTCTCTTACATTTCTCCTTTAAGTGCAGTTTCTGTCATGGAAGATAAGCTGCATAAGCGAAGTCCACCTCCAGAGACTATAAAA TCTAAACTTAATACTTCAGTAGATACTCACAAGATAAAATCCAGCCCATCACCTGAAGTTGTTAAACCCAAAATAACTCATTCTCCTGAT TCTGTAAAGTCTAAGGCCACTTATGTGAACAGCCAAGCTACTGGTGAAAGAAGATTGGCAAATAAGATAGAACATGAGCTATCAAGATGC AGTTTTCATCCAATTCCTACTCGAAGCAGTACATTAGAAACTACAAAGAGTCCTCTTATCATTGATAAAAATGAGCATTTTACAGTTTAC AGAGATCCTGCACTTATTGGGTCAGAAACAGGAGCTAATCATATTTCACCTTTCCTAAGCCAGCATCCTTTTCCTCTTCACTCCTCATCT CATAGAACCTGTTTAAATCCAGGTACCCATCATCCTGCCTTAACTCCTGCACCCCATTTACTAGCCGGATCATCTAGTCAAACTCCATTA CCTACCATTAACACTCATCCTCTGACTAGTGGTCCACACCATGCTGTTCATCACCCTCATTTACTTCCCACTGTGTTACCTGGAGTGCCT ACTGCCTCCTTACTTGGTGGCCACCCACGACTAGAGAGTGCTCATGCCAGCAGCTTGAGCCACTTAGCGCTAGCACACCAGCAACAACAA CAGTTGTTACAGCACCAGTCACCTCATCTTCTTGGACAAGCCCATCCTTCTGCTTCATATAATCAGCTTGGACTTTATCCAATTATTTGG CAGTATCCAAATGGAACACATGCATACTCAGGACTTGGTTTGCCTTCTTCTAAGTGGGTTCACCCAGAAAATGCAGTTAATGCTGAAGCT TCATTAAGGAGGAATTCTCCCAGTCCTTGGCTACATCAGCCCACCCCTGTGACCTCAGCAGATGGTATTGGATTACTTAGTCACATTCCT GTCAGACCTTCCAGTGCAGAGCCTCATCGGCCTCTTAAAATTACAGCCCATTCCAGTCCACCATTGACAAAAACTTTAGTAGATCATCAT AAGGAAGAATTAGAAAGAAAAGCTTTTATGGAACCATTACGGTCTGTTGCATCCACATCAGCCAAAAATGACCTGGATCTAAATAGGTCA CAGACTGGAAAAGATTGTCACTTACATAGGCATTTTGTGGATCCAGTATTAAATCAGTTACAGAGGCCACCCCAGGAGACTGGAGAGAGG TTAAACAAATACAAAGAGGAACACCGTCGAATTCTTCAAGAAAGTATTGATGTTGCTCCCTTTACAACTAAAATCAAGGGACTTGAGGGT GAGAGAGAGAATTATTCCAGAGTGGCATCATCATCTTCCAGTCCTAAAAGCCATATCATCAAACAAGATATGGATGTAGAACGCTCAGTA TCAGATCTTTATAAAATGAAGCACTCAGTGCCTCAGAGTTTACCCCAAAGTAACTATTTCACTACATTGTCTAATAGTGTGGTCAATGAA CCACCAAGATCATACCCATCCAAAGAAGTTTCAAATATTTACGGTGATAAACAGAGTAATGCCCTTGCAGCGGCAGCAGCTAATCCTCAA ACTCTGACTTCATTTATAACATCTCTTTCAAAGCCTCCACCTTTGATTAAACACCAACCAGAAAGTGAAGGTTTAGTAGGCAAGATACCA GAACATCTTCCACATCAGATTGCATCTCACTCAGTAACAACCTTCAGAAATGATTGTAGGAGTCCTACCCATTTGACAGTTTCTTCTACA AATACACTCCGCAGTATGCCTGCATTACATAGAGCACCAGTATTTCACCCACCAATCCATCACAGCCTGGAAAGAAAGGAAGGCAGCTAT AGTAGTCTTTCCCCTCCAACTTTAACTCCGGTGATGCCAGTAAATGCTGGTGGTAAAGTTCAAGAATCACAGAAGCCTCCAACTCTAATA CCCGAACCAAAAGACTCCCAGGCAAATTTTAAGAGTTCTTCAGAACAGAGTTTGACGGAGATGTGGAGACCTAATAATAACCTCAGCAAA GAGAAAACTGAATGGCATGTGGAGAAAAGCAGCGGAAAGTTACAGGCTGCTATGGCATCTGTCATTGTGCGTCCATCTTCTAGTACAAAA ACTGATAGTATGCCAGCAATGCAGTTAGCTTCTAAAGATCGTGTTAGTGAAAGATCTTCAGCTGGGGCACATAAAACAGATTGCCTCAAA CTAGCAGAAGCCGGAGAAACTGGAAGAATCATTTTGCCAAATGTGAATTCAGACAGTGTTCACACAAAATCTGAAAAAAACTTTCAGGCT GTCTCACAGGGCAGTGTTCCCAGTTCAGTCATGTCTGCTGTAAATACGATGTGTAATACCAAAACGGATGTAATCACATCTGCTGCCGAT ACTACCAGTGTTTCCAGCTGGGGTGGTTCAGAAGTAATTTCCTCTTTATCAAATACCATTTTGGCCTCTACATCATCAGAATGTGTATCT TCAAAAAGTGTCAGTCAGCCAGTGGCTCAAAAACAAGAATGCAAGGTCAGCACCACAGCACCAGTTACATTAGCCAGTAGTAAGACAGGA AGTGTTGTTCAACCCAGTTCTGGGTTCTCAGGCACAACTGATTTTATCCATTTAAAAAAGCACAAGGCAGCATTGGCTGCAGCTCAGTAT AAAAGTAGTAATGCCAGTGAGACTGAACCTAATGCTATAAAAAATCAGACACTTTCAGCCTCCCTTCCTCTGGATAGCACTGTAATCTGT AGTACAATTAACAAAGCAAACTCTGTAGGAAATGGGCAAGCTTCCCAGACAAGTCAACCAAACTACCATACTAAACTGAAAAAGGCCTGG CTCACCAGACACTCAGAAGAAGATAAAAATACTAATAAAATGGAAAATTCAGGGAATTCTGTATCAGAAATTATTAAGCCATGTTCTGTC AACTTAATAGCCTCTACATCTAGTGATATACAAAATAGTGTAGATAGTAAGATCATAGTTGATAAATATGTAAAAGATGATAAAGTCAAC AGGAGAAAAGCCAAAAGAACTTATGAATCTGGCTCTGAAAGTGGAGACTCAGATGAAAGTGAAAGCAAGTCAGAGCAAAGGACTAAAAGA CAACCTAAGCCAACTTACAAAAAGAAGCAAAATGATTTGCAAAAGAGAAAAGGTGAAATAGAAGAAGATTTGAAACCCAATGGAGTTCTC AGCAGGAGTGCCAAAGAAAGAAGTAAACTGAAGTTGCAAAGCAACAGTAATACTGGCATTCCTCGTTCAGTATTGAAAGATTGGCGTAAA GTCAAGAAGCTGAAGCAAACTGGGGAATCCTTTTTACAGGATGACTCCTGCTGTGAGATAGGGCCTAATTTACAAAAGTGTCGAGAATGT AGACTTATTCGCAGTAAAAAAGGAGAAGAACCAGCTCACTCACCAGTATTTTGTAGATTTTACTACTTTAGACGGTTGTCATTTAGTAAA AACGGAGTAGTTAGAATAGATGGTTTCTCTTCTCCTGACCAATATGATGATGAAGCTATGAGTTTGTGGACACATGAAAATTTTGAAGAT GATGAACTAGATATAGAGACTTCTAAATATATCTTGGATATAATAGGTGATAAGTTCTGTCAATTAGTAACATCTGAAAAAACAGCTTTG TCCTGGGTGAAAAAGGATGCCAAAATTGCCTGGAAAAGAGCAGTGAGAGGAGTCCGGGAGATGTGTGATGCATGTGAAGCAACATTGTTT AACATTCACTGGGTCTGCCAAAAATGTGGATTTGTGGTCTGCTTAGATTGTTACAAGGCAAAGGAAAGGAAGAGTTCTAGAGATAAAGAA CTATATGCTTGGATGAAGTGTGTGAAGGGACAGCCTCATGATCACAAACATTTAATGCCAACCCAAATTATACCTGGTTCTGTTTTGACA GATCTTCTAGATGCCATGCACACTCTTAGGGAAAAATATGGTATTAAATCCCATTGTCATTGTACTAACAAACAGAATTTACAAGTTGGA AATTTTCCTACAATGAATGGTGTATCTCAAGTTTTACAGAATGTTCTTAATCACAGTAATAAAATTTCTCTGTGCATGCCTGAGTCTCAG CAGCAAAATACTCCTCCGAAGTCTGAGAAAAATGGTGGCAGCAGCCCAGAGAGTGATGTAGGCACAGATAACAAGTTAACTCCTCCAGAA TCCCAGTCACCACTGCACTGGTTAGCAGATCTTGCAGAGCAAAAAGCCAGAGAGGAAAAAAAAGAAAACAAAGAACTTACCCTTGAAAAC CAAATTAAAGAAGAAAGAGAACAAGACAACTCTGAATCTCCAAATGGCAGAACATCACCTCTTGTGTCCCAGAATAATGAACAAGGCTCA ACCTTACGGGATTTGCTGACTACAACAGCTGGAAAGCTACGTGTGGGGTCTACAGATGCTGGCATTGCCTTTGCCCCAGTATATTCAATG GGAGCCCCAAGTAGCAAAAGTGGACGGACTATGCCTAACATTCTTGATGACATAATTGCTTCAGTTGTTGAAAACAAAATTCCACCAAGT AAAACCTCCAAGATAAATGTAAAACCAGAGCTTAAAGAAGAGCCTGAAGAAAGCATAATATCTGCAGTGGATGAAAATAATAAATTATAC AGTGATATACCACATTCTTGGATCTGTGAGAAGCATATTTTATGGCTTAAGGATTATAAGAATAGCAGTAATTGGAAGCTTTTCAAAGAA TGTTGGAAACAAGGACAGCCTGCAGTGGTTTCTGGTGTGCATAAGAAAATGAACATTAGCCTATGGAAGGCGGAATCAATTAGTCTTGAT TTTGGAGACCACCAAGCTGATCTCCTGAACTGCAAAGATAGCATCATTTCAAATGCCAATGTTAAGGAATTCTGGGATGGTTTTGAAGAA GTTTCAAAACGGCAGAAAAACAAGAGTGGAGAAACAGTTGTTTTAAAATTGAAAGACTGGCCTTCAGGAGAAGACTTCAAGACTATGATG CCAGCAAGATACGAAGATCTTTTAAAAAGTCTGCCATTGCCAGAATATTGTAATCCAGAAGGAAAATTCAATTTGGCCTCTCATTTGCCA GGATTTTTTGTACGTCCTGATCTAGGACCCAGGTTGTGCAGTGCCTATGGTGTAGTTGCTGCTAAAGATCATGATATAGGAACAACAAAT CTCCATATTGAAGTTTCTGATGTTGTAAATATACTAGTTTATGTTGGCATAGCAAAAGGAAATGGCATTCTCTCAAAAGCAGGAATTCTC AAGAAATTTGAGGAAGAAGATTTGGATGACATTTTAAGGAAAAGATTGAAGGACTCAAGTGAAATACCTGGTGCTCTGTGGCATATTTAT GCTGGGAAAGATGTTGACAAGATAAGGGAATTTCTTCAAAAGATTTCAAAAGAACAAGGCCTTGAAGTTCTACCAGAACATGATCCAATA CGTGACCAAAGTTGGTATGTGAACAAAAAGCTCCGTCAAAGGCTGCTTGAAGAATATGGAGTCAGAACCTGTACTCTTATTCAGTTCCTT GGTGATGCTATTGTTTTGCCAGCGGGAGCACTTCATCAGGTTCAGAATTTTCACAGCTGTATTCAGGTAACTGAAGATTTTGTGTCTCCA GAACATCTTGTAGAGTCATTTCATTTAACACAGGAACTGAGACTTTTGAAGGAAGAAATCAATTATGATGATAAACTACAGGTTAAAAAT ATTTTGTATCATGCAGTCAAAGAAATGGTGAGAGCCTTGAAGATACACGAGGATGAAGTAGAGGATATGGAAGAAAATTAAGTGTGATCC AGTTTGATATTTTTAGGTTGTTGAACTGGGATTACTTAACCTTGAATGATGATATGTATGCACACTGACTTTAAGCTTCATAAAACCATC AGTGCCAAGAAATTCTCTTTGTAGTAATTACTTGTTACTGACACCACAGCAGTATAGCATATGTCACAGCTCCTGTGATTCAATGTTATA AAACAAGCAGAATTTTAAAAGCAGCACTATATAGCTGTTTTGTATTATAGTGTATATGATGTTTGTGAAAATGCCAGATTTAAAATGATG TATTTATTTTTGGTAAAAAATAAAAAATTCTATGCTATATTGTTGATCAAGTGTAAATGTGACCTTGTACAGTTTACTAAAATTACTGAT ATTTTTCACTACATTGAGACAGTTACTGTGAGAATAGGACACAAACACCAGCTATTGCCTGCATCTGGGAAATTGCTGAATCGCACAGCA GTCATGTCATAATCAGAAAATTACTGCCAAATAATTGTAAAATTTGTAAAGTATAAAGTATATAAAGTAGATACTAAATACAGACACTTC AATATTTTGTTGAAGCTATTGACTGTACAATTAAACATTTTCAAAAGGTGTAATTTATTTAAAATTGTCTCATTTTGGTAAAATTTATGT GAACTTTTAAAGCTAAATATTAAACTTAATATGCTATGTAAATATATACATATATACATTTAATGATGTATTTTTTTAAAACATTGGCTT GCTTTTGTTAAAGTGCAAGTGTTACATATGGCTTTGTACATTAAAGTTGAAAGGGGTTTTACATTTTCCATTAAAAGGACTTTATCAAAA >63253_63253_1_PCDHGA4-JMJD1C_PCDHGA4_chr5_140737188_ENST00000571252_JMJD1C_chr10_65024524_ENST00000399262_length(amino acids)=3236AA_BP=806 MAAPPARPDHTRLLQICLLLGVLVEIRAEQILYSVFEEQEEGSVVGNIAKDLGLAPRELAERGVRIVSRGRTQLFALNPRSGTLVTAGRI DREELCDRSPNCVTNLEILLEDTVKILRVEVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYFSL DVQSGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSVRENVPVGTRLLTVKATDPD EGANGDVTYSFRKVRDKISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQESS SPGTVIALFNVHDSDSGGNGLVTCSIPDNLPFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDINDNPP TFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGDP PLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLKSSEPGLFAVGLHTGEVRTAR ALLDRDALKQRLVVVVQDHGQPPLSATVTLTVAVADSIPDVLADLGSLKPSADPDDSGLTLYLVVAVAAVSCVFLAFVTVLLALKLRRWH KSRLLHAEGSRLAGVPASHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFSQPSYADTLISRESCEKSEPLLITQDLLETKGDPNLQTFK PLVERNIPSSVTAVEFLVDKQLDFLTEDSAFQPYQDDIDSLNPVLRDNPQLHEEVKVWVKEQKVQEIFMQGPYSLNGYRVRVYRQDSATQ WFTGIITHHDLFTRTMIVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRANQNVNAVHSHYTRAQANSPRPAMNSQAA VPKQNTHQQQQQRSIRPNKRKGSDSSIPDEEKMKEEKYDYISRGENPKGKNKHLMNKRRKPEEDEKKLNMKRLRTDNVSDFSESSDSENS NKRIIDNSSEQKPENELKNKNTSKINGEEGKPHNNEKAGEETLKNSQPPWDQIQEDKKHEEAEKRKSVDTQLQEDMIIHSSEQSTVSDHN SNDLLPQECNMDKTHTMELLPKEKFVSRPPTPKCVIDITNDTNLEKVAQENSSTFGLQTLQKMDPNVSDSKHSIANAKFLETAKKDSDQS WVSDVVKVDLTQSSVTNASSGNDHLNMEKEKYVSYISPLSAVSVMEDKLHKRSPPPETIKSKLNTSVDTHKIKSSPSPEVVKPKITHSPD SVKSKATYVNSQATGERRLANKIEHELSRCSFHPIPTRSSTLETTKSPLIIDKNEHFTVYRDPALIGSETGANHISPFLSQHPFPLHSSS HRTCLNPGTHHPALTPAPHLLAGSSSQTPLPTINTHPLTSGPHHAVHHPHLLPTVLPGVPTASLLGGHPRLESAHASSLSHLALAHQQQQ QLLQHQSPHLLGQAHPSASYNQLGLYPIIWQYPNGTHAYSGLGLPSSKWVHPENAVNAEASLRRNSPSPWLHQPTPVTSADGIGLLSHIP VRPSSAEPHRPLKITAHSSPPLTKTLVDHHKEELERKAFMEPLRSVASTSAKNDLDLNRSQTGKDCHLHRHFVDPVLNQLQRPPQETGER LNKYKEEHRRILQESIDVAPFTTKIKGLEGERENYSRVASSSSSPKSHIIKQDMDVERSVSDLYKMKHSVPQSLPQSNYFTTLSNSVVNE PPRSYPSKEVSNIYGDKQSNALAAAAANPQTLTSFITSLSKPPPLIKHQPESEGLVGKIPEHLPHQIASHSVTTFRNDCRSPTHLTVSST NTLRSMPALHRAPVFHPPIHHSLERKEGSYSSLSPPTLTPVMPVNAGGKVQESQKPPTLIPEPKDSQANFKSSSEQSLTEMWRPNNNLSK EKTEWHVEKSSGKLQAAMASVIVRPSSSTKTDSMPAMQLASKDRVSERSSAGAHKTDCLKLAEAGETGRIILPNVNSDSVHTKSEKNFQA VSQGSVPSSVMSAVNTMCNTKTDVITSAADTTSVSSWGGSEVISSLSNTILASTSSECVSSKSVSQPVAQKQECKVSTTAPVTLASSKTG SVVQPSSGFSGTTDFIHLKKHKAALAAAQYKSSNASETEPNAIKNQTLSASLPLDSTVICSTINKANSVGNGQASQTSQPNYHTKLKKAW LTRHSEEDKNTNKMENSGNSVSEIIKPCSVNLIASTSSDIQNSVDSKIIVDKYVKDDKVNRRKAKRTYESGSESGDSDESESKSEQRTKR QPKPTYKKKQNDLQKRKGEIEEDLKPNGVLSRSAKERSKLKLQSNSNTGIPRSVLKDWRKVKKLKQTGESFLQDDSCCEIGPNLQKCREC RLIRSKKGEEPAHSPVFCRFYYFRRLSFSKNGVVRIDGFSSPDQYDDEAMSLWTHENFEDDELDIETSKYILDIIGDKFCQLVTSEKTAL SWVKKDAKIAWKRAVRGVREMCDACEATLFNIHWVCQKCGFVVCLDCYKAKERKSSRDKELYAWMKCVKGQPHDHKHLMPTQIIPGSVLT DLLDAMHTLREKYGIKSHCHCTNKQNLQVGNFPTMNGVSQVLQNVLNHSNKISLCMPESQQQNTPPKSEKNGGSSPESDVGTDNKLTPPE SQSPLHWLADLAEQKAREEKKENKELTLENQIKEEREQDNSESPNGRTSPLVSQNNEQGSTLRDLLTTTAGKLRVGSTDAGIAFAPVYSM GAPSSKSGRTMPNILDDIIASVVENKIPPSKTSKINVKPELKEEPEESIISAVDENNKLYSDIPHSWICEKHILWLKDYKNSSNWKLFKE CWKQGQPAVVSGVHKKMNISLWKAESISLDFGDHQADLLNCKDSIISNANVKEFWDGFEEVSKRQKNKSGETVVLKLKDWPSGEDFKTMM PARYEDLLKSLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRLCSAYGVVAAKDHDIGTTNLHIEVSDVVNILVYVGIAKGNGILSKAGIL KKFEEEDLDDILRKRLKDSSEIPGALWHIYAGKDVDKIREFLQKISKEQGLEVLPEHDPIRDQSWYVNKKLRQRLLEEYGVRTCTLIQFL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PCDHGA4-JMJD1C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PCDHGA4-JMJD1C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PCDHGA4-JMJD1C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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