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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARHGEF4-TCF7L2 (FusionGDB2 ID:6335)

Fusion Gene Summary for ARHGEF4-TCF7L2

Fusion gene summary

Fusion gene information	Fusion gene name: ARHGEF4-TCF7L2
	Fusion gene ID: 6335
		Hgene	Tgene
	Gene symbol	ARHGEF4	TCF7L2
	Gene ID	50649	6934
	Gene name	Rho guanine nucleotide exchange factor 4	transcription factor 7 like 2
	Synonyms	ASEF\|ASEF1\|GEF4\|SMIM39\|STM6	TCF-4\|TCF4
	Cytomap	2q21.1	10q25.2-q25.3
	Type of gene	protein-coding	protein-coding
	Description	rho guanine nucleotide exchange factor 4APC-stimulated guanine nucleotide exchange factor 1Rho guanine nucleotide exchange factor (GEF) 4	transcription factor 7-like 2HMG box transcription factor 4T-cell factor 4T-cell-specific transcription factor 4hTCF-4transcription factor 7-like 2 (T-cell specific, HMG-box)
	Modification date	20200313	20200315
	UniProtAcc	Q9NR80	Q9NQB0
	Ensembl transtripts involved in fusion gene	ENST00000326016, ENST00000355771, ENST00000392953, ENST00000409303, ENST00000409359, ENST00000428230, ENST00000439368, ENST00000525839,	ENST00000349937, ENST00000352065, ENST00000355717, ENST00000355995, ENST00000369395, ENST00000369397, ENST00000534894, ENST00000536810, ENST00000538897, ENST00000543371, ENST00000545257, ENST00000542695, ENST00000369386, ENST00000369389, ENST00000466338,
Fusion gene scores	* DoF score	6 X 7 X 2=84	12 X 11 X 10=1320
	# samples	7	17
	** MAII score	log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/1320*10)=-2.95693127810811 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARHGEF4 [Title/Abstract] AND TCF7L2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARHGEF4(131806489)-TCF7L2(114901011), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TCF7L2	GO:0000122	negative regulation of transcription by RNA polymerase II	12799378
Tgene	TCF7L2	GO:0006357	regulation of transcription by RNA polymerase II	9727977
Tgene	TCF7L2	GO:0032092	positive regulation of protein binding	12799378
Tgene	TCF7L2	GO:0032350	regulation of hormone metabolic process	15525634
Tgene	TCF7L2	GO:0042593	glucose homeostasis	15525634
Tgene	TCF7L2	GO:0043433	negative regulation of DNA-binding transcription factor activity	12799378
Tgene	TCF7L2	GO:0045444	fat cell differentiation	10937998
Tgene	TCF7L2	GO:0045892	negative regulation of transcription, DNA-templated	12799378\|15525634
Tgene	TCF7L2	GO:0045944	positive regulation of transcription by RNA polymerase II	9065401\|19168596
Tgene	TCF7L2	GO:0048625	myoblast fate commitment	10937998

Fusion gene breakpoints across ARHGEF4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TCF7L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BF923603	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+

Top

Fusion Gene ORF analysis for ARHGEF4-TCF7L2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000326016	ENST00000349937	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000326016	ENST00000352065	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000326016	ENST00000355717	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000326016	ENST00000355995	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000326016	ENST00000369395	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000326016	ENST00000369397	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000326016	ENST00000534894	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000326016	ENST00000536810	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000326016	ENST00000538897	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000326016	ENST00000543371	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000326016	ENST00000545257	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000355771	ENST00000349937	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000355771	ENST00000352065	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000355771	ENST00000355717	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000355771	ENST00000355995	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000355771	ENST00000369395	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000355771	ENST00000369397	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000355771	ENST00000534894	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000355771	ENST00000536810	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000355771	ENST00000538897	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000355771	ENST00000543371	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000355771	ENST00000545257	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000392953	ENST00000349937	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000392953	ENST00000352065	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000392953	ENST00000355717	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000392953	ENST00000355995	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000392953	ENST00000369395	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000392953	ENST00000369397	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000392953	ENST00000534894	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000392953	ENST00000536810	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000392953	ENST00000538897	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000392953	ENST00000543371	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000392953	ENST00000545257	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409303	ENST00000349937	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409303	ENST00000352065	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409303	ENST00000355717	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409303	ENST00000355995	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409303	ENST00000369395	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409303	ENST00000369397	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409303	ENST00000534894	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409303	ENST00000536810	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409303	ENST00000538897	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409303	ENST00000543371	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409303	ENST00000545257	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409359	ENST00000349937	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409359	ENST00000352065	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409359	ENST00000355717	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409359	ENST00000355995	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409359	ENST00000369395	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409359	ENST00000369397	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409359	ENST00000534894	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409359	ENST00000536810	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409359	ENST00000538897	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409359	ENST00000543371	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000409359	ENST00000545257	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000428230	ENST00000349937	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000428230	ENST00000352065	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000428230	ENST00000355717	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000428230	ENST00000355995	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000428230	ENST00000369395	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000428230	ENST00000369397	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000428230	ENST00000534894	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000428230	ENST00000536810	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000428230	ENST00000538897	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000428230	ENST00000543371	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000428230	ENST00000545257	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000439368	ENST00000349937	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000439368	ENST00000352065	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000439368	ENST00000355717	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000439368	ENST00000355995	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000439368	ENST00000369395	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000439368	ENST00000369397	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000439368	ENST00000534894	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000439368	ENST00000536810	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000439368	ENST00000538897	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000439368	ENST00000543371	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000439368	ENST00000545257	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000525839	ENST00000349937	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000525839	ENST00000352065	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000525839	ENST00000355717	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000525839	ENST00000355995	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000525839	ENST00000369395	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000525839	ENST00000369397	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000525839	ENST00000534894	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000525839	ENST00000536810	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000525839	ENST00000538897	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000525839	ENST00000543371	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-3CDS	ENST00000525839	ENST00000545257	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-5UTR	ENST00000326016	ENST00000542695	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-5UTR	ENST00000355771	ENST00000542695	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-5UTR	ENST00000392953	ENST00000542695	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-5UTR	ENST00000409303	ENST00000542695	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-5UTR	ENST00000409359	ENST00000542695	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-5UTR	ENST00000428230	ENST00000542695	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-5UTR	ENST00000439368	ENST00000542695	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-5UTR	ENST00000525839	ENST00000542695	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000326016	ENST00000369386	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000326016	ENST00000369389	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000326016	ENST00000466338	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000355771	ENST00000369386	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000355771	ENST00000369389	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000355771	ENST00000466338	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000392953	ENST00000369386	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000392953	ENST00000369389	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000392953	ENST00000466338	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000409303	ENST00000369386	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000409303	ENST00000369389	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000409303	ENST00000466338	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000409359	ENST00000369386	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000409359	ENST00000369389	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000409359	ENST00000466338	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000428230	ENST00000369386	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000428230	ENST00000369389	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000428230	ENST00000466338	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000439368	ENST00000369386	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000439368	ENST00000369389	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000439368	ENST00000466338	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000525839	ENST00000369386	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000525839	ENST00000369389	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+
intron-intron	ENST00000525839	ENST00000466338	ARHGEF4	chr2	131806489	+	TCF7L2	chr10	114901011	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for ARHGEF4-TCF7L2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGEF4-TCF7L2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:131806489/:114901011)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARHGEF4 Q9NR80	TCF7L2 Q9NQB0
FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269\|PubMed:10947987, ECO:0000269\|PubMed:12598901, ECO:0000269\|PubMed:17145773, ECO:0000269\|PubMed:17599059, ECO:0000269\|PubMed:19893577}.	FUNCTION: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269\|PubMed:12408868, ECO:0000269\|PubMed:12727872, ECO:0000269\|PubMed:19443654, ECO:0000269\|PubMed:22699938, ECO:0000269\|PubMed:9727977}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ARHGEF4-TCF7L2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARHGEF4-TCF7L2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ARHGEF4-TCF7L2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ARHGEF4-TCF7L2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source