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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PCMT1-TAB2 (FusionGDB2 ID:63354)

Fusion Gene Summary for PCMT1-TAB2

check button Fusion gene summary
Fusion gene informationFusion gene name: PCMT1-TAB2
Fusion gene ID: 63354
HgeneTgene
Gene symbol

PCMT1

TAB2

Gene ID

5110

23118

Gene nameprotein-L-isoaspartate (D-aspartate) O-methyltransferaseTGF-beta activated kinase 1 (MAP3K7) binding protein 2
SynonymsPIMTCHTD2|MAP3K7IP2|TAB-2
Cytomap

6q25.1

6q25.1

Type of geneprotein-codingprotein-coding
Descriptionprotein-L-isoaspartate(D-aspartate) O-methyltransferaseL-isoaspartyl protein carboxyl methyltransferaseepididymis secretory sperm binding proteinprotein L-isoaspartyl/D-aspartyl methyltransferaseprotein-beta-aspartate methyltransferaseTGF-beta-activated kinase 1 and MAP3K7-binding protein 2TAK1-binding protein 2mitogen-activated protein kinase kinase kinase 7-interacting protein 2
Modification date2020031320200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000367378, ENST00000367380, 
ENST00000367384, ENST00000464889, 
ENST00000544496, ENST00000480010, 
ENST00000286332, ENST00000367456, 
ENST00000392282, ENST00000461481, 
ENST00000538427, ENST00000536230, 
Fusion gene scores* DoF score5 X 4 X 4=8010 X 10 X 3=300
# samples 510
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCMT1 [Title/Abstract] AND TAB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTAB2(149639151)-PCMT1(150111090), # samples:2
PCMT1(150071092)-TAB2(149718740), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTAB2

GO:0032496

response to lipopolysaccharide

19193853

TgeneTAB2

GO:0045860

positive regulation of protein kinase activity

11460167


check buttonFusion gene breakpoints across PCMT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TAB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8372-01APCMT1chr6

150071092

+TAB2chr6

149718740

+


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Fusion Gene ORF analysis for PCMT1-TAB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000367378ENST00000286332PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000367378ENST00000367456PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000367378ENST00000392282PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000367378ENST00000461481PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000367378ENST00000538427PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000367380ENST00000286332PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000367380ENST00000367456PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000367380ENST00000392282PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000367380ENST00000461481PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000367380ENST00000538427PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000367384ENST00000286332PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000367384ENST00000367456PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000367384ENST00000392282PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000367384ENST00000461481PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000367384ENST00000538427PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000464889ENST00000286332PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000464889ENST00000367456PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000464889ENST00000392282PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000464889ENST00000461481PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000464889ENST00000538427PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000544496ENST00000286332PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000544496ENST00000367456PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000544496ENST00000392282PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000544496ENST00000461481PCMT1chr6

150071092

+TAB2chr6

149718740

+
5CDS-intronENST00000544496ENST00000538427PCMT1chr6

150071092

+TAB2chr6

149718740

+
In-frameENST00000367378ENST00000536230PCMT1chr6

150071092

+TAB2chr6

149718740

+
In-frameENST00000367380ENST00000536230PCMT1chr6

150071092

+TAB2chr6

149718740

+
In-frameENST00000367384ENST00000536230PCMT1chr6

150071092

+TAB2chr6

149718740

+
In-frameENST00000464889ENST00000536230PCMT1chr6

150071092

+TAB2chr6

149718740

+
In-frameENST00000544496ENST00000536230PCMT1chr6

150071092

+TAB2chr6

149718740

+
intron-3CDSENST00000480010ENST00000536230PCMT1chr6

150071092

+TAB2chr6

149718740

+
intron-intronENST00000480010ENST00000286332PCMT1chr6

150071092

+TAB2chr6

149718740

+
intron-intronENST00000480010ENST00000367456PCMT1chr6

150071092

+TAB2chr6

149718740

+
intron-intronENST00000480010ENST00000392282PCMT1chr6

150071092

+TAB2chr6

149718740

+
intron-intronENST00000480010ENST00000461481PCMT1chr6

150071092

+TAB2chr6

149718740

+
intron-intronENST00000480010ENST00000538427PCMT1chr6

150071092

+TAB2chr6

149718740

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367384PCMT1chr6150071092+ENST00000536230TAB2chr6149718740+1213514156992278
ENST00000367378PCMT1chr6150071092+ENST00000536230TAB2chr6149718740+1212513155991278
ENST00000464889PCMT1chr6150071092+ENST00000536230TAB2chr6149718740+1212513155991278
ENST00000367380PCMT1chr6150071092+ENST00000536230TAB2chr6149718740+96126233740235
ENST00000544496PCMT1chr6150071092+ENST00000536230TAB2chr6149718740+88218359661200

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367384ENST00000536230PCMT1chr6150071092+TAB2chr6149718740+0.0287995990.97120035
ENST00000367378ENST00000536230PCMT1chr6150071092+TAB2chr6149718740+0.027822890.9721771
ENST00000464889ENST00000536230PCMT1chr6150071092+TAB2chr6149718740+0.027822890.9721771
ENST00000367380ENST00000536230PCMT1chr6150071092+TAB2chr6149718740+0.0168851110.9831149
ENST00000544496ENST00000536230PCMT1chr6150071092+TAB2chr6149718740+0.0161721040.98382795

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Fusion Genomic Features for PCMT1-TAB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PCMT1chr6150071092+TAB2chr6149718739+1.46E-060.99999857
PCMT1chr6150071092+TAB2chr6149718739+1.46E-060.99999857

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PCMT1-TAB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:149639151/chr6:150111090)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTAB2chr6:150071092chr6:149718740ENST0000028633216532_619534694.0Coiled coilOntology_term=ECO:0000255
TgeneTAB2chr6:150071092chr6:149718740ENST0000036745638532_619534694.0Coiled coilOntology_term=ECO:0000255
TgeneTAB2chr6:150071092chr6:149718740ENST0000039228204532_6190537.0Coiled coilOntology_term=ECO:0000255
TgeneTAB2chr6:150071092chr6:149718740ENST0000053842738532_619534694.0Coiled coilOntology_term=ECO:0000255
TgeneTAB2chr6:150071092chr6:149718740ENST00000392282048_510537.0DomainCUE
TgeneTAB2chr6:150071092chr6:149718740ENST0000028633216663_693534694.0Zinc fingerRanBP2-type
TgeneTAB2chr6:150071092chr6:149718740ENST0000036745638663_693534694.0Zinc fingerRanBP2-type
TgeneTAB2chr6:150071092chr6:149718740ENST0000039228204663_6930537.0Zinc fingerRanBP2-type
TgeneTAB2chr6:150071092chr6:149718740ENST0000053842738663_693534694.0Zinc fingerRanBP2-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTAB2chr6:150071092chr6:149718740ENST00000286332168_51534694.0DomainCUE
TgeneTAB2chr6:150071092chr6:149718740ENST00000367456388_51534694.0DomainCUE
TgeneTAB2chr6:150071092chr6:149718740ENST00000538427388_51534694.0DomainCUE


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Fusion Gene Sequence for PCMT1-TAB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63354_63354_1_PCMT1-TAB2_PCMT1_chr6_150071092_ENST00000367378_TAB2_chr6_149718740_ENST00000536230_length(transcript)=1212nt_BP=513nt
CCGCCATCCCGCCGTCCCGCTCGGTGACCGGAGACACAGCCGGGAACGCGACTGATCAGGCTACCGAGCCGGGCCGCAGGGCGAAAGCGG
TGCGGTCCGAGGCCTCAGAAAGGGACACGCAGCAGCGGAAGTGGCGCTGACTCAGCCCGGCCTCCCTGCAGTCCCCTGGCAGCGGTAGCA
GCCACAGGGGCGGGCGGCTGGGCCACACGCCTCCCCCGCCCTCGGCCCCACCCGGCCGCACCCTAAGCCGCGCGGCGTCACAGAGCGCAT
GCGTGCCGCGGGGGATGCCGGGAGCGCGCAGTGGCGGCAGCGGCGGCGACGGCAGTAACAGCGGCAGCTACAGCGGGGACGCGAGCGGGG
CGGTGACGGTGTGGGAGGTGGTCTCACTCTTGGGAAAACTGCTGGGCACCGTCGTCGCGCTGAAGGTGGTTCTGTACCTGCTCCGAGTGT
GCTTAGCGATGGCCTGGAAATCCGGCGGCGCCAGCCACTCGGAGCTAATCCACAATCTCCGCACTCTTTTGGTACACCAGAAGGCCAGAA
TGGAACGACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCTGGATAAATTAAAATCTGAGGTTAATGAAATGGAAAATAATCTAACTC
GAAGGCGCCTGAAAAGATCAAATTCTATATCCCAGATACCTTCCCTTGAAGAAATGCAGCAGCTGAGAAGTTGTAATAGACAACTCCAGA
TTGACATTGACTGCTTAACCAAAGAAATTGATCTTTTTCAAGCCCGAGGACCACATTTTAACCCCAGCGCTATTCATAACTTTTATGACA
ATATTGGATTTGTAGGTCCTGTGCCACCAAAACCCAAAGATCAAAGGTCCATCATCAAAACACCAAAGACTCAAGACACAGAAGATGATG
AGGGAGCTCAGTGGAATTGTACCGCCTGTACTTTTTTGAACCATCCAGCCTTAATTCGCTGTGAACAGTGTGAGATGCCAAGGCATTTCT
GAGCCAAATGGCCCTGTATCTTCTCTAAAACCACATCTAAAGTTCAAGAAACTAGTCTGTCATCGGGAAAAAGTTTCACTGCTACATAGG
ATTTTGTCAAATTGAAGGTGTGACAAGATGGTGTTCTGCTAATGTTAAATGTCAGCCCACAGAGCTAATAATACCTCAGTATAATGTCAT

>63354_63354_1_PCMT1-TAB2_PCMT1_chr6_150071092_ENST00000367378_TAB2_chr6_149718740_ENST00000536230_length(amino acids)=278AA_BP=120
MQSPGSGSSHRGGRLGHTPPPPSAPPGRTLSRAASQSACVPRGMPGARSGGSGGDGSNSGSYSGDASGAVTVWEVVSLLGKLLGTVVALK
VVLYLLRVCLAMAWKSGGASHSELIHNLRTLLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQL
RSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTEDDEGAQWNCTACTFLNHPALIRCE

--------------------------------------------------------------
>63354_63354_2_PCMT1-TAB2_PCMT1_chr6_150071092_ENST00000367380_TAB2_chr6_149718740_ENST00000536230_length(transcript)=961nt_BP=262nt
GCGGCGTCACAGAGCGCATGCGTGCCGCGGGGGATGCCGGGAGCGCGCAGTGGCGGCAGCGGCGGCGACGGCAGTAACAGCGGCAGCTAC
AGCGGGGACGCGAGCGGGGCGGTGACGGTGTGGGAGGTGGTCTCACTCTTGGGAAAACTGCTGGGCACCGTCGTCGCGCTGAAGGTGGTT
CTGTACCTGCTCCGAGTGTGCTTAGCGATGGCCTGGAAATCCGGCGGCGCCAGCCACTCGGAGCTAATCCACAATCTCCGCACTCTTTTG
GTACACCAGAAGGCCAGAATGGAACGACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCTGGATAAATTAAAATCTGAGGTTAATGAA
ATGGAAAATAATCTAACTCGAAGGCGCCTGAAAAGATCAAATTCTATATCCCAGATACCTTCCCTTGAAGAAATGCAGCAGCTGAGAAGT
TGTAATAGACAACTCCAGATTGACATTGACTGCTTAACCAAAGAAATTGATCTTTTTCAAGCCCGAGGACCACATTTTAACCCCAGCGCT
ATTCATAACTTTTATGACAATATTGGATTTGTAGGTCCTGTGCCACCAAAACCCAAAGATCAAAGGTCCATCATCAAAACACCAAAGACT
CAAGACACAGAAGATGATGAGGGAGCTCAGTGGAATTGTACCGCCTGTACTTTTTTGAACCATCCAGCCTTAATTCGCTGTGAACAGTGT
GAGATGCCAAGGCATTTCTGAGCCAAATGGCCCTGTATCTTCTCTAAAACCACATCTAAAGTTCAAGAAACTAGTCTGTCATCGGGAAAA
AGTTTCACTGCTACATAGGATTTTGTCAAATTGAAGGTGTGACAAGATGGTGTTCTGCTAATGTTAAATGTCAGCCCACAGAGCTAATAA

>63354_63354_2_PCMT1-TAB2_PCMT1_chr6_150071092_ENST00000367380_TAB2_chr6_149718740_ENST00000536230_length(amino acids)=235AA_BP=77
MPGARSGGSGGDGSNSGSYSGDASGAVTVWEVVSLLGKLLGTVVALKVVLYLLRVCLAMAWKSGGASHSELIHNLRTLLVHQKARMERLQ
RELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFV

--------------------------------------------------------------
>63354_63354_3_PCMT1-TAB2_PCMT1_chr6_150071092_ENST00000367384_TAB2_chr6_149718740_ENST00000536230_length(transcript)=1213nt_BP=514nt
CCCGCCATCCCGCCGTCCCGCTCGGTGACCGGAGACACAGCCGGGAACGCGACTGATCAGGCTACCGAGCCGGGCCGCAGGGCGAAAGCG
GTGCGGTCCGAGGCCTCAGAAAGGGACACGCAGCAGCGGAAGTGGCGCTGACTCAGCCCGGCCTCCCTGCAGTCCCCTGGCAGCGGTAGC
AGCCACAGGGGCGGGCGGCTGGGCCACACGCCTCCCCCGCCCTCGGCCCCACCCGGCCGCACCCTAAGCCGCGCGGCGTCACAGAGCGCA
TGCGTGCCGCGGGGGATGCCGGGAGCGCGCAGTGGCGGCAGCGGCGGCGACGGCAGTAACAGCGGCAGCTACAGCGGGGACGCGAGCGGG
GCGGTGACGGTGTGGGAGGTGGTCTCACTCTTGGGAAAACTGCTGGGCACCGTCGTCGCGCTGAAGGTGGTTCTGTACCTGCTCCGAGTG
TGCTTAGCGATGGCCTGGAAATCCGGCGGCGCCAGCCACTCGGAGCTAATCCACAATCTCCGCACTCTTTTGGTACACCAGAAGGCCAGA
ATGGAACGACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCTGGATAAATTAAAATCTGAGGTTAATGAAATGGAAAATAATCTAACT
CGAAGGCGCCTGAAAAGATCAAATTCTATATCCCAGATACCTTCCCTTGAAGAAATGCAGCAGCTGAGAAGTTGTAATAGACAACTCCAG
ATTGACATTGACTGCTTAACCAAAGAAATTGATCTTTTTCAAGCCCGAGGACCACATTTTAACCCCAGCGCTATTCATAACTTTTATGAC
AATATTGGATTTGTAGGTCCTGTGCCACCAAAACCCAAAGATCAAAGGTCCATCATCAAAACACCAAAGACTCAAGACACAGAAGATGAT
GAGGGAGCTCAGTGGAATTGTACCGCCTGTACTTTTTTGAACCATCCAGCCTTAATTCGCTGTGAACAGTGTGAGATGCCAAGGCATTTC
TGAGCCAAATGGCCCTGTATCTTCTCTAAAACCACATCTAAAGTTCAAGAAACTAGTCTGTCATCGGGAAAAAGTTTCACTGCTACATAG
GATTTTGTCAAATTGAAGGTGTGACAAGATGGTGTTCTGCTAATGTTAAATGTCAGCCCACAGAGCTAATAATACCTCAGTATAATGTCA

>63354_63354_3_PCMT1-TAB2_PCMT1_chr6_150071092_ENST00000367384_TAB2_chr6_149718740_ENST00000536230_length(amino acids)=278AA_BP=120
MQSPGSGSSHRGGRLGHTPPPPSAPPGRTLSRAASQSACVPRGMPGARSGGSGGDGSNSGSYSGDASGAVTVWEVVSLLGKLLGTVVALK
VVLYLLRVCLAMAWKSGGASHSELIHNLRTLLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQL
RSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTEDDEGAQWNCTACTFLNHPALIRCE

--------------------------------------------------------------
>63354_63354_4_PCMT1-TAB2_PCMT1_chr6_150071092_ENST00000464889_TAB2_chr6_149718740_ENST00000536230_length(transcript)=1212nt_BP=513nt
CCGCCATCCCGCCGTCCCGCTCGGTGACCGGAGACACAGCCGGGAACGCGACTGATCAGGCTACCGAGCCGGGCCGCAGGGCGAAAGCGG
TGCGGTCCGAGGCCTCAGAAAGGGACACGCAGCAGCGGAAGTGGCGCTGACTCAGCCCGGCCTCCCTGCAGTCCCCTGGCAGCGGTAGCA
GCCACAGGGGCGGGCGGCTGGGCCACACGCCTCCCCCGCCCTCGGCCCCACCCGGCCGCACCCTAAGCCGCGCGGCGTCACAGAGCGCAT
GCGTGCCGCGGGGGATGCCGGGAGCGCGCAGTGGCGGCAGCGGCGGCGACGGCAGTAACAGCGGCAGCTACAGCGGGGACGCGAGCGGGG
CGGTGACGGTGTGGGAGGTGGTCTCACTCTTGGGAAAACTGCTGGGCACCGTCGTCGCGCTGAAGGTGGTTCTGTACCTGCTCCGAGTGT
GCTTAGCGATGGCCTGGAAATCCGGCGGCGCCAGCCACTCGGAGCTAATCCACAATCTCCGCACTCTTTTGGTACACCAGAAGGCCAGAA
TGGAACGACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCTGGATAAATTAAAATCTGAGGTTAATGAAATGGAAAATAATCTAACTC
GAAGGCGCCTGAAAAGATCAAATTCTATATCCCAGATACCTTCCCTTGAAGAAATGCAGCAGCTGAGAAGTTGTAATAGACAACTCCAGA
TTGACATTGACTGCTTAACCAAAGAAATTGATCTTTTTCAAGCCCGAGGACCACATTTTAACCCCAGCGCTATTCATAACTTTTATGACA
ATATTGGATTTGTAGGTCCTGTGCCACCAAAACCCAAAGATCAAAGGTCCATCATCAAAACACCAAAGACTCAAGACACAGAAGATGATG
AGGGAGCTCAGTGGAATTGTACCGCCTGTACTTTTTTGAACCATCCAGCCTTAATTCGCTGTGAACAGTGTGAGATGCCAAGGCATTTCT
GAGCCAAATGGCCCTGTATCTTCTCTAAAACCACATCTAAAGTTCAAGAAACTAGTCTGTCATCGGGAAAAAGTTTCACTGCTACATAGG
ATTTTGTCAAATTGAAGGTGTGACAAGATGGTGTTCTGCTAATGTTAAATGTCAGCCCACAGAGCTAATAATACCTCAGTATAATGTCAT

>63354_63354_4_PCMT1-TAB2_PCMT1_chr6_150071092_ENST00000464889_TAB2_chr6_149718740_ENST00000536230_length(amino acids)=278AA_BP=120
MQSPGSGSSHRGGRLGHTPPPPSAPPGRTLSRAASQSACVPRGMPGARSGGSGGDGSNSGSYSGDASGAVTVWEVVSLLGKLLGTVVALK
VVLYLLRVCLAMAWKSGGASHSELIHNLRTLLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQL
RSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTEDDEGAQWNCTACTFLNHPALIRCE

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>63354_63354_5_PCMT1-TAB2_PCMT1_chr6_150071092_ENST00000544496_TAB2_chr6_149718740_ENST00000536230_length(transcript)=882nt_BP=183nt
GCGGCAGCTACAGCGGGGACGCGAGCGGGGCGGTGACGGTGTGGGAGGTGGTCTCACTCTTGGGAAAACTGCTGGGCACCGTCGTCGCGC
TGAAGGTGGTTCTGTACCTGCTCCGAGTGTGCTTAGCGATGGCCTGGAAATCCGGCGGCGCCAGCCACTCGGAGCTAATCCACAATCTCC
GCACTCTTTTGGTACACCAGAAGGCCAGAATGGAACGACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCTGGATAAATTAAAATCTG
AGGTTAATGAAATGGAAAATAATCTAACTCGAAGGCGCCTGAAAAGATCAAATTCTATATCCCAGATACCTTCCCTTGAAGAAATGCAGC
AGCTGAGAAGTTGTAATAGACAACTCCAGATTGACATTGACTGCTTAACCAAAGAAATTGATCTTTTTCAAGCCCGAGGACCACATTTTA
ACCCCAGCGCTATTCATAACTTTTATGACAATATTGGATTTGTAGGTCCTGTGCCACCAAAACCCAAAGATCAAAGGTCCATCATCAAAA
CACCAAAGACTCAAGACACAGAAGATGATGAGGGAGCTCAGTGGAATTGTACCGCCTGTACTTTTTTGAACCATCCAGCCTTAATTCGCT
GTGAACAGTGTGAGATGCCAAGGCATTTCTGAGCCAAATGGCCCTGTATCTTCTCTAAAACCACATCTAAAGTTCAAGAAACTAGTCTGT
CATCGGGAAAAAGTTTCACTGCTACATAGGATTTTGTCAAATTGAAGGTGTGACAAGATGGTGTTCTGCTAATGTTAAATGTCAGCCCAC

>63354_63354_5_PCMT1-TAB2_PCMT1_chr6_150071092_ENST00000544496_TAB2_chr6_149718740_ENST00000536230_length(amino acids)=200AA_BP=42
MGKLLGTVVALKVVLYLLRVCLAMAWKSGGASHSELIHNLRTLLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSI
SQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTEDDEGAQWNCTAC

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Fusion Gene PPI Analysis for PCMT1-TAB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTAB2chr6:150071092chr6:149718740ENST0000028633216675_685534.3333333333334694.0polyubiquitin
TgeneTAB2chr6:150071092chr6:149718740ENST0000036745638675_685534.3333333333334694.0polyubiquitin
TgeneTAB2chr6:150071092chr6:149718740ENST0000039228204675_6850537.0polyubiquitin
TgeneTAB2chr6:150071092chr6:149718740ENST0000053842738675_685534.3333333333334694.0polyubiquitin


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PCMT1-TAB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PCMT1-TAB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource