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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PCMTD2-MACROD2 (FusionGDB2 ID:63392)

Fusion Gene Summary for PCMTD2-MACROD2

check button Fusion gene summary
Fusion gene informationFusion gene name: PCMTD2-MACROD2
Fusion gene ID: 63392
HgeneTgene
Gene symbol

PCMTD2

MACROD2

Gene ID

55251

140733

Gene nameprotein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2mono-ADP ribosylhydrolase 2
SynonymsC20orf36C20orf133|C2orf133
Cytomap

20q13.33

20p12.1

Type of geneprotein-codingprotein-coding
Descriptionprotein-L-isoaspartate O-methyltransferase domain-containing protein 2ADP-ribose glycohydrolase MACROD2MACRO domain containing 2MACRO domain-containing protein 2O-acetyl-ADP-ribose deacetylase MACROD2[Protein ADP-ribosylaspartate] hydrolase MACROD2[Protein ADP-ribosylglutamate] hydrolase[Protein ADP-ribosylglutamate]
Modification date2020031320200313
UniProtAcc.

A1Z1Q3

Ensembl transtripts involved in fusion geneENST00000299468, ENST00000308824, 
ENST00000369758, ENST00000266078, 
ENST00000609372, 		ENST00000402914, 
ENST00000378058, ENST00000407045, 
ENST00000464883, ENST00000217246, 
ENST00000310348, 
Fusion gene scores* DoF score9 X 5 X 7=31537 X 34 X 11=13838
# samples 941
** MAII scorelog2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/13838*10)=-5.07686772601114
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCMTD2 [Title/Abstract] AND MACROD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPCMTD2(62891625)-MACROD2(15210586), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMACROD2

GO:0042278

purine nucleoside metabolic process

21257746

TgeneMACROD2

GO:0051725

protein de-ADP-ribosylation

23474712


check buttonFusion gene breakpoints across PCMTD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MACROD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-7080-01APCMTD2chr20

62891625

-MACROD2chr20

15210586

+
ChimerDB4PRADTCGA-HC-7080-01APCMTD2chr20

62891625

+MACROD2chr20

15210586

+
ChimerDB4PRADTCGA-HC-7080PCMTD2chr20

62891625

+MACROD2chr20

15210586

+


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Fusion Gene ORF analysis for PCMTD2-MACROD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000299468ENST00000402914PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
5CDS-5UTRENST00000308824ENST00000402914PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
5CDS-5UTRENST00000369758ENST00000402914PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
5CDS-intronENST00000299468ENST00000378058PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
5CDS-intronENST00000299468ENST00000407045PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
5CDS-intronENST00000299468ENST00000464883PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
5CDS-intronENST00000308824ENST00000378058PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
5CDS-intronENST00000308824ENST00000407045PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
5CDS-intronENST00000308824ENST00000464883PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
5CDS-intronENST00000369758ENST00000378058PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
5CDS-intronENST00000369758ENST00000407045PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
5CDS-intronENST00000369758ENST00000464883PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
In-frameENST00000299468ENST00000217246PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
In-frameENST00000299468ENST00000310348PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
In-frameENST00000308824ENST00000217246PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
In-frameENST00000308824ENST00000310348PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
In-frameENST00000369758ENST00000217246PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
In-frameENST00000369758ENST00000310348PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
intron-3CDSENST00000266078ENST00000217246PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
intron-3CDSENST00000266078ENST00000310348PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
intron-3CDSENST00000609372ENST00000217246PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
intron-3CDSENST00000609372ENST00000310348PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
intron-5UTRENST00000266078ENST00000402914PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
intron-5UTRENST00000609372ENST00000402914PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
intron-intronENST00000266078ENST00000378058PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
intron-intronENST00000266078ENST00000407045PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
intron-intronENST00000266078ENST00000464883PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
intron-intronENST00000609372ENST00000378058PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
intron-intronENST00000609372ENST00000407045PCMTD2chr20

62891625

+MACROD2chr20

15210586

+
intron-intronENST00000609372ENST00000464883PCMTD2chr20

62891625

+MACROD2chr20

15210586

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000299468PCMTD2chr2062891625+ENST00000217246MACROD2chr2015210586+4639458251317430
ENST00000299468PCMTD2chr2062891625+ENST00000310348MACROD2chr2015210586+1387458251386454
ENST00000369758PCMTD2chr2062891625+ENST00000217246MACROD2chr2015210586+4642461281320430
ENST00000369758PCMTD2chr2062891625+ENST00000310348MACROD2chr2015210586+1390461281389454
ENST00000308824PCMTD2chr2062891625+ENST00000217246MACROD2chr2015210586+461543411293430
ENST00000308824PCMTD2chr2062891625+ENST00000310348MACROD2chr2015210586+136343411362454

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000299468ENST00000217246PCMTD2chr2062891625+MACROD2chr2015210586+8.47E-050.99991524
ENST00000299468ENST00000310348PCMTD2chr2062891625+MACROD2chr2015210586+0.001069080.9989309
ENST00000369758ENST00000217246PCMTD2chr2062891625+MACROD2chr2015210586+8.46E-050.99991536
ENST00000369758ENST00000310348PCMTD2chr2062891625+MACROD2chr2015210586+0.0010802510.9989197
ENST00000308824ENST00000217246PCMTD2chr2062891625+MACROD2chr2015210586+8.75E-050.9999125
ENST00000308824ENST00000310348PCMTD2chr2062891625+MACROD2chr2015210586+0.0011571370.99884284

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Fusion Genomic Features for PCMTD2-MACROD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PCMTD2chr2062891625+MACROD2chr2015210585+3.16E-060.9999968
PCMTD2chr2062891625+MACROD2chr2015210585+3.16E-060.9999968
PCMTD2chr2062891625+MACROD2chr2015210585+3.16E-060.9999968
PCMTD2chr2062891625+MACROD2chr2015210585+3.16E-060.9999968

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PCMTD2-MACROD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:62891625/chr20:15210586)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MACROD2

A1Z1Q3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). {ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712, ECO:0000269|PubMed:23474714}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMACROD2chr20:62891625chr20:15210586ENST00000217246417247_388139426.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:62891625chr20:15210586ENST00000310348418247_388139449.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:62891625chr20:15210586ENST00000378058010247_3880214.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:62891625chr20:15210586ENST000003780580106_90214.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:62891625chr20:15210586ENST00000402914014247_3880214.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:62891625chr20:15210586ENST000004029140146_90214.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:62891625chr20:15210586ENST0000040704506247_388099.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:62891625chr20:15210586ENST00000407045066_9099.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:62891625chr20:15210586ENST0000037805801059_2400214.0DomainMacro
TgeneMACROD2chr20:62891625chr20:15210586ENST0000040291401459_2400214.0DomainMacro
TgeneMACROD2chr20:62891625chr20:15210586ENST000004070450659_240099.0DomainMacro
TgeneMACROD2chr20:62891625chr20:15210586ENST00000217246417185_191139426.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST00000310348418185_191139449.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST00000378058010185_1910214.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST0000037805801077_790214.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST0000037805801090_920214.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST0000037805801097_1020214.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST00000402914014185_1910214.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST0000040291401477_790214.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST0000040291401490_920214.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST0000040291401497_1020214.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST0000040704506185_191099.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST000004070450677_79099.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST000004070450690_92099.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST000004070450697_102099.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCMTD2chr20:62891625chr20:15210586ENST00000308824+26279_286102362.0Compositional biasNote=Poly-Arg
HgenePCMTD2chr20:62891625chr20:15210586ENST00000369758+26279_286102335.0Compositional biasNote=Poly-Arg
TgeneMACROD2chr20:62891625chr20:15210586ENST000002172464176_9139426.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:62891625chr20:15210586ENST000003103484186_9139449.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:62891625chr20:15210586ENST0000021724641759_240139426.0DomainMacro
TgeneMACROD2chr20:62891625chr20:15210586ENST0000031034841859_240139449.0DomainMacro
TgeneMACROD2chr20:62891625chr20:15210586ENST0000021724641777_79139426.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST0000021724641790_92139426.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST0000021724641797_102139426.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST0000031034841877_79139449.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST0000031034841890_92139449.0RegionSubstrate binding
TgeneMACROD2chr20:62891625chr20:15210586ENST0000031034841897_102139449.0RegionSubstrate binding


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Fusion Gene Sequence for PCMTD2-MACROD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63392_63392_1_PCMTD2-MACROD2_PCMTD2_chr20_62891625_ENST00000299468_MACROD2_chr20_15210586_ENST00000217246_length(transcript)=4639nt_BP=458nt
CGGCGGATGTTTACGGCGGCCGAGGTTGGAGCGGCGCTGCTCGGCCGCGGACACACGAGGGACGCGCCCGAGGAGCTGCAGGTGGCAGCC
CAGGCGGTCCGAACCCGTCGGCCGGCCGAGCCTGGAGTATTGCCTAAGTGTAATCTTGAACATGGGCGGTGCTGTGAGTGCTGGTGAAGA
CAATGATGAGCTGATAGATAATTTGAAAGAAGCACAGTATATCCGGACTGAGCTGGTAGAGCAGGCTTTCAGAGCTATCGATCGTGCAGA
CTATTATCTTGAAGAATTTAAAGAAAATGCTTATAAAGACTTGGCATGGAAGCATGGAAACATTCACCTCTCAGCCCCGTGCATCTACTC
GGAGGTGATGGAAGCCCTAGATCTGCAGCCTGGACTCTCGTTTCTGAACCTGGGCAGTGGCACTGGGTATCTCAGCTCCATGGTGGGCCT
CATTCTAGATGTCATCCATACTGTAGGGCCAATAGCCAGGGGCCATATTAATGGTTCCCACAAGGAAGACCTTGCAAATTGCTATAAATC
ATCTCTGAAGCTCGTGAAAGAAAATAACATCCGATCAGTTGCATTTCCCTGCATCTCAACAGGCATTTATGGCTTTCCCAACGAGCCTGC
TGCAGTCATTGCCCTCAACACCATTAAGGAATGGCTTGCCAAGAATCACCATGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGT
TGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGA
TTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGT
GCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGAC
AGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAG
CTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCA
AGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCC
AGGTCCTGATGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAATGACAATCCTCAGCATCGCAAGGCCTCTCCTGGCT
CTGGGGGAGCTCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTGGGGGTGGGGGGAAGGCAAGTCCCATGGAAGGACGGGGAATCCTT
TACTCTAATTTCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAAAAGAAAGAAAAAAAAGAAAAAAAAAGTTTCCTTTAATTTGGTGG
AGGGACCCATGTTGACGCATCTTTCAGGCATTATCCTTGTAATTTCTGTCTTTTCTCTTACAACTTTGCCCCAGGGTCACAGTGGCTTGA
TTGAACACTCACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTTATTTCACAAAGCTGGTCACACAGTGGTTTATTCAAAGGAAGGGG
AGGAAGACAGTGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCAATGAGCCCAGCAGCAGTATAATCCCCAGACAGAGGAGGCAGGAT
AGAAAATGGGCAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGACAATGAGGTGAAAATATTTTCTTCAGGGTTCCCAAGGCACAATTT
GTTCCAAGTGGCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGAGCAGAGTGCAGAGGCATAACAGAAGGGTGGGCCCTGGCAGCCAT
CTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTTGACACTGACTTTCAGCAGAGCTTACTTGGTTCATGAGGTCTTCA
CATGGAGACTACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAAAGGATGGCCCTTTGCTAGGTGTTACAGTTAAAAGCTAAGAAAAG
GGGCAGTGCATTTAGGACCCAAACATATGCCTATGAATATCAAAAGCTCCTCCTGAAATTGCTGTGAGTTTTCCATAAAAGAATATCCTG
TCTTCACCCAAGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAATTACAGGAAATTAGAGCTTTTGCTTGCAGTTCTGCCTTCCTGGCC
TGTGTTTAAATGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATTCAATGGTTGGTCCCCTCACCCAGAAAACCCTGAAGGGGAGGATA
CAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTGGTATAGTGGGCACAAGGGATGGCGACCATGAGGATGCCAGGCAT
CATCACCAATATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTACTTCCCACAGCCTCCCCGGGTTCCAAAGTCATGTCATTGTTTTCA
GTGGAAACATATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCTTGTAAGGGCTTTAGAACTAAAACTTACTTATATTGTTTTTCCTT
AACAGAGGGAGAAAAATAGTGGATTATTATTTCTAAAATAAAAGGATGTTCTGCTTTCTAAATATCCCATCAAAATCTTCAGTTTTGCAC
TTTTTTGATGGAAAATTCATCTTATCTTCCTATGACTTTGGTTTTAGCCTTTCTGAATTTGTTACCCCTTCTGGATGGCTTATTTGATAT
ACTGGAATAGTTAACAAGCTATACTTCAGCATATGCACTATATTCTAACAAATTTTTTTTAATAAAATCAAGACATCAGCAAGAATGACA
TTTACGTGACCTCATAATGTGGGATTATGGCCTTCTGTTGCTATTCCAGTTTGATATGGAAGCATCTATATCCTCTATTGCCGTTAGATG
TTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATCCAAGAAACGATGTCATCCAAATATTGACAGTTTCTACATTTCAT
GCCATCTTTATAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGTATTTGACAAGTGCAATCTGCTAGAAGCTCGTTTTTCTTGTGACT
CCCAAATGTTAGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAAAAAAACATGAGGGAAACAGAGGGACAGAGATTTTCTAATGAACA
ATGATGGAAGAGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGAAATTATCCAGCCCTGGCATTCTCCTTATCATCAATGACAGTCAT
TTTATTCATTTATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGGGAATTCTCTCTGCCTAAAAATTCTAGAAGAATGAAAGTAATCTT
TGTATCCAGGAAACTAAGAGAATGAGGAATAAATATCTTCAGCCCGACTCCTGAATTTGTTTATTCTTCCATCTATAATTAGATTGTGTT
TTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACAGTTTTATGCTTTAAAACAAATGATAAAGTTAATTTCCAATTCAA
TAGTGAAATATTAACAATCTAACTATAGCCAGATCAAAGACACCTGAACACAGAAAACCTTTATTTGCTGGTGCTGCCATTGCACAGGCT
GTACAATGAAATAGATTTGAAAAGCTGATTGATTTTCCCGCACATAAATTCTGGATGTCAATTTCCAACCAAACTCCAATACAGCTATGT
GGCATGAAGAGTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTAGTCATGTTTGCATACAGAGGATCAAAGTAGGCCTTCACCATAAT
AGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTTTTCCTCTAGCTGGTAACTATTCAGATGATGGACAAGTCTTCTTT
CATAAAAGATTACAAAGAAGGCATCCGAATCACTGTCTGTGATACTGGGTCACATATTAATCACTGCAGCTAATTGTAAATCTTTCTATG
AAACACTGAAAAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATGCACTTGATTTGAAAAGACATTTCTCTGTATGTGGCGCATGTCGG
CTTTGCTTTGAAAAATAACAAAGTTAGCAGAATATGTTCAATATATTTTCTTGGGGAATAGGGTTTTTATTACATGATTCATTAAGGATT
TGCCTTACCCTGACATTTGTGATATAAAGGAAAATCAGAAAAAAAGTAATTTTCTTGATCAAGATATGTTTTTACTTAATGCAAATAAAT
GTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGGTATAAACTGCTAAATAGGATAATACGTGCCTCTTTTGTTAAACC
GGCATTTAAATGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCATCTGTGCCATACACTAAAAAACAACTGTTGCCTTCATACTATAT

>63392_63392_1_PCMTD2-MACROD2_PCMTD2_chr20_62891625_ENST00000299468_MACROD2_chr20_15210586_ENST00000217246_length(amino acids)=430AA_BP=144
MERRCSAADTRGTRPRSCRWQPRRSEPVGRPSLEYCLSVILNMGGAVSAGEDNDELIDNLKEAQYIRTELVEQAFRAIDRADYYLEEFKE
NAYKDLAWKHGNIHLSAPCIYSEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILDVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKEN
NIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEE
KQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEEL

--------------------------------------------------------------
>63392_63392_2_PCMTD2-MACROD2_PCMTD2_chr20_62891625_ENST00000299468_MACROD2_chr20_15210586_ENST00000310348_length(transcript)=1387nt_BP=458nt
CGGCGGATGTTTACGGCGGCCGAGGTTGGAGCGGCGCTGCTCGGCCGCGGACACACGAGGGACGCGCCCGAGGAGCTGCAGGTGGCAGCC
CAGGCGGTCCGAACCCGTCGGCCGGCCGAGCCTGGAGTATTGCCTAAGTGTAATCTTGAACATGGGCGGTGCTGTGAGTGCTGGTGAAGA
CAATGATGAGCTGATAGATAATTTGAAAGAAGCACAGTATATCCGGACTGAGCTGGTAGAGCAGGCTTTCAGAGCTATCGATCGTGCAGA
CTATTATCTTGAAGAATTTAAAGAAAATGCTTATAAAGACTTGGCATGGAAGCATGGAAACATTCACCTCTCAGCCCCGTGCATCTACTC
GGAGGTGATGGAAGCCCTAGATCTGCAGCCTGGACTCTCGTTTCTGAACCTGGGCAGTGGCACTGGGTATCTCAGCTCCATGGTGGGCCT
CATTCTAGATGTCATCCATACTGTAGGGCCAATAGCCAGGGGCCATATTAATGGTTCCCACAAGGAAGACCTTGCAAATTGCTATAAATC
ATCTCTGAAGCTCGTGAAAGAAAATAACATCCGATCAGTTGCATTTCCCTGCATCTCAACAGGCATTTATGGCTTTCCCAACGAGCCTGC
TGCAGTCATTGCCCTCAACACCATTAAGGAATGGCTTGCCAAGAATCACCATGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGT
TGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGA
TTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGT
GCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGAC
AGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAG
CTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCA
AGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCC
AGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGCACA

>63392_63392_2_PCMTD2-MACROD2_PCMTD2_chr20_62891625_ENST00000299468_MACROD2_chr20_15210586_ENST00000310348_length(amino acids)=454AA_BP=144
MERRCSAADTRGTRPRSCRWQPRRSEPVGRPSLEYCLSVILNMGGAVSAGEDNDELIDNLKEAQYIRTELVEQAFRAIDRADYYLEEFKE
NAYKDLAWKHGNIHLSAPCIYSEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILDVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKEN
NIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEE
KQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEEL
SSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDVEMNSQVDKVNDPTESQQEDQLIAGAQDEAKEQRN

--------------------------------------------------------------
>63392_63392_3_PCMTD2-MACROD2_PCMTD2_chr20_62891625_ENST00000308824_MACROD2_chr20_15210586_ENST00000217246_length(transcript)=4615nt_BP=434nt
GTTGGAGCGGCGCTGCTCGGCCGCGGACACACGAGGGACGCGCCCGAGGAGCTGCAGGTGGCAGCCCAGGCGGTCCGAACCCGTCGGCCG
GCCGAGCCTGGAGTATTGCCTAAGTGTAATCTTGAACATGGGCGGTGCTGTGAGTGCTGGTGAAGACAATGATGAGCTGATAGATAATTT
GAAAGAAGCACAGTATATCCGGACTGAGCTGGTAGAGCAGGCTTTCAGAGCTATCGATCGTGCAGACTATTATCTTGAAGAATTTAAAGA
AAATGCTTATAAAGACTTGGCATGGAAGCATGGAAACATTCACCTCTCAGCCCCGTGCATCTACTCGGAGGTGATGGAAGCCCTAGATCT
GCAGCCTGGACTCTCGTTTCTGAACCTGGGCAGTGGCACTGGGTATCTCAGCTCCATGGTGGGCCTCATTCTAGATGTCATCCATACTGT
AGGGCCAATAGCCAGGGGCCATATTAATGGTTCCCACAAGGAAGACCTTGCAAATTGCTATAAATCATCTCTGAAGCTCGTGAAAGAAAA
TAACATCCGATCAGTTGCATTTCCCTGCATCTCAACAGGCATTTATGGCTTTCCCAACGAGCCTGCTGCAGTCATTGCCCTCAACACCAT
TAAGGAATGGCTTGCCAAGAATCACCATGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAA
AATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGA
GAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGC
AGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGA
TCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACT
TTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGC
TCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAGA
TGAAGCGAAGGAACAAAGAAATGGAACTAAATGACAATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGCTCGGGAAGATAGCA
GCACACGCTGTGGAGGAGGGTGGGGGTGGGGGGAAGGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATTTCTCCAGCTGCATT
TTGTTCCGTTTATCTGCAGAAAAAGAAAGAAAAAAAAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCATGTTGACGCATCTTT
CAGGCATTATCCTTGTAATTTCTGTCTTTTCTCTTACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTCACATGTGTATCCTG
GCCCCTGTCTGCTTTCTTGGTTATTTCACAAAGCTGGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAGTGGTTTGATAAGCT
GCAGGATAAATTTTAGGAATCAATGAGCCCAGCAGCAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGGCAAAAGCCTCGGAA
ACCACTTGGAAAAGGTCTGGACAATGAGGTGAAAATATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTGGCTAATGAGAAATA
TGGAAGCTGAATTTTTTCCAGAGCAGAGTGCAGAGGCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCTTCCTTCCTAACCAT
GGTGGCAGGTGCATCCTTCTTTGACACTGACTTTCAGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACTACCAGCAAGAGGTG
ACTCTCTGCTGCATAACTGTAAAGGATGGCCCTTTGCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCATTTAGGACCCAAAC
ATATGCCTATGAATATCAAAAGCTCCTCCTGAAATTGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCAAGGCTTGACAGCCC
ACAGAGTGGTCTCATTTGAAATTACAGGAAATTAGAGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAATGCTGTCACTTGTT
TATGCCAAGTTCAAGGCTGATTCAATGGTTGGTCCCCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAAGGGGGGCAGCAGTA
CTAAAAACCCAAGATGCCAGTGGTATAGTGGGCACAAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAATATCTATCCTAGAGC
CAGTATAAGGCCAGATGCCTACTTCCCACAGCCTCCCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACATATCGTTTGTTGCAT
ATCTTCTTAAATCCATCTTCCTTGTAAGGGCTTTAGAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGAGAAAAATAGTGGAT
TATTATTTCTAAAATAAAAGGATGTTCTGCTTTCTAAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATGGAAAATTCATCTTA
TCTTCCTATGACTTTGGTTTTAGCCTTTCTGAATTTGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAGTTAACAAGCTATAC
TTCAGCATATGCACTATATTCTAACAAATTTTTTTTAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGACCTCATAATGTGGGA
TTATGGCCTTCTGTTGCTATTCCAGTTTGATATGGAAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTTTCAGAAAAGTAACG
AAAAGGCTCATTTTAAAGAATCCAAGAAACGATGTCATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTATAACTCAATTGAAA
GTTGCCGTCATTCTTGTGAAGTATTTGACAAGTGCAATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTTAGTGCTACTTAGCC
TCAGTAATGAGTTACAGTTGAAAAAAACATGAGGGAAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAGAGACCTAATGTCCT
TGCTAGAAACAGCCAGGATGGAAATTATCCAGCCCTGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATTTATTTCAAATGTGG
GTGGGCTAGAAGTGGAAGGAGGGAATTCTCTCTGCCTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGGAAACTAAGAGAATG
AGGAATAAATATCTTCAGCCCGACTCCTGAATTTGTTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTGCTTTGTCATGCTTT
TTGGTTGTTATTTGGCTATACAGTTTTATGCTTTAAAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATATTAACAATCTAACT
ATAGCCAGATCAAAGACACCTGAACACAGAAAACCTTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAAATAGATTTGAAAAG
CTGATTGATTTTCCCGCACATAAATTCTGGATGTCAATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGAGTTACAGGAGGGAG
GGAGGAAAATAGCCCTATGTTAGTCATGTTTGCATACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATTAAAATGGTCCTCGC
TGTAGGAGAGACAAAGGGGCTTTTCCTCTAGCTGGTAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGATTACAAAGAAGGCAT
CCGAATCACTGTCTGTGATACTGGGTCACATATTAATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAAAAGCCTCTTTGTGA
ATTAATACAGTTCTGCTTGATGCACTTGATTTGAAAAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTGAAAAATAACAAAGT
TAGCAGAATATGTTCAATATATTTTCTTGGGGAATAGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCCTGACATTTGTGATA
TAAAGGAAAATCAGAAAAAAAGTAATTTTCTTGATCAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTTGCTTGCAAGGAAAA
AAAAATGGCTTCTGATATCTGGTATAAACTGCTAAATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAATGCTGGACTGCTTC
TAAATCTGTTTGTTTCTTTTCATCTGTGCCATACACTAAAAAACAACTGTTGCCTTCATACTATATTTGTTAGAGCAGAATACAAATAAA

>63392_63392_3_PCMTD2-MACROD2_PCMTD2_chr20_62891625_ENST00000308824_MACROD2_chr20_15210586_ENST00000217246_length(amino acids)=430AA_BP=144
LERRCSAADTRGTRPRSCRWQPRRSEPVGRPSLEYCLSVILNMGGAVSAGEDNDELIDNLKEAQYIRTELVEQAFRAIDRADYYLEEFKE
NAYKDLAWKHGNIHLSAPCIYSEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILDVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKEN
NIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEE
KQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEEL

--------------------------------------------------------------
>63392_63392_4_PCMTD2-MACROD2_PCMTD2_chr20_62891625_ENST00000308824_MACROD2_chr20_15210586_ENST00000310348_length(transcript)=1363nt_BP=434nt
GTTGGAGCGGCGCTGCTCGGCCGCGGACACACGAGGGACGCGCCCGAGGAGCTGCAGGTGGCAGCCCAGGCGGTCCGAACCCGTCGGCCG
GCCGAGCCTGGAGTATTGCCTAAGTGTAATCTTGAACATGGGCGGTGCTGTGAGTGCTGGTGAAGACAATGATGAGCTGATAGATAATTT
GAAAGAAGCACAGTATATCCGGACTGAGCTGGTAGAGCAGGCTTTCAGAGCTATCGATCGTGCAGACTATTATCTTGAAGAATTTAAAGA
AAATGCTTATAAAGACTTGGCATGGAAGCATGGAAACATTCACCTCTCAGCCCCGTGCATCTACTCGGAGGTGATGGAAGCCCTAGATCT
GCAGCCTGGACTCTCGTTTCTGAACCTGGGCAGTGGCACTGGGTATCTCAGCTCCATGGTGGGCCTCATTCTAGATGTCATCCATACTGT
AGGGCCAATAGCCAGGGGCCATATTAATGGTTCCCACAAGGAAGACCTTGCAAATTGCTATAAATCATCTCTGAAGCTCGTGAAAGAAAA
TAACATCCGATCAGTTGCATTTCCCTGCATCTCAACAGGCATTTATGGCTTTCCCAACGAGCCTGCTGCAGTCATTGCCCTCAACACCAT
TAAGGAATGGCTTGCCAAGAATCACCATGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAA
AATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGA
GAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGC
AGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGA
TCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACT
TTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGC
TCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAG
TCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAA

>63392_63392_4_PCMTD2-MACROD2_PCMTD2_chr20_62891625_ENST00000308824_MACROD2_chr20_15210586_ENST00000310348_length(amino acids)=454AA_BP=144
LERRCSAADTRGTRPRSCRWQPRRSEPVGRPSLEYCLSVILNMGGAVSAGEDNDELIDNLKEAQYIRTELVEQAFRAIDRADYYLEEFKE
NAYKDLAWKHGNIHLSAPCIYSEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILDVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKEN
NIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEE
KQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEEL
SSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDVEMNSQVDKVNDPTESQQEDQLIAGAQDEAKEQRN

--------------------------------------------------------------
>63392_63392_5_PCMTD2-MACROD2_PCMTD2_chr20_62891625_ENST00000369758_MACROD2_chr20_15210586_ENST00000217246_length(transcript)=4642nt_BP=461nt
CGGCGGCGGATGTTTACGGCGGCCGAGGTTGGAGCGGCGCTGCTCGGCCGCGGACACACGAGGGACGCGCCCGAGGAGCTGCAGGTGGCA
GCCCAGGCGGTCCGAACCCGTCGGCCGGCCGAGCCTGGAGTATTGCCTAAGTGTAATCTTGAACATGGGCGGTGCTGTGAGTGCTGGTGA
AGACAATGATGAGCTGATAGATAATTTGAAAGAAGCACAGTATATCCGGACTGAGCTGGTAGAGCAGGCTTTCAGAGCTATCGATCGTGC
AGACTATTATCTTGAAGAATTTAAAGAAAATGCTTATAAAGACTTGGCATGGAAGCATGGAAACATTCACCTCTCAGCCCCGTGCATCTA
CTCGGAGGTGATGGAAGCCCTAGATCTGCAGCCTGGACTCTCGTTTCTGAACCTGGGCAGTGGCACTGGGTATCTCAGCTCCATGGTGGG
CCTCATTCTAGATGTCATCCATACTGTAGGGCCAATAGCCAGGGGCCATATTAATGGTTCCCACAAGGAAGACCTTGCAAATTGCTATAA
ATCATCTCTGAAGCTCGTGAAAGAAAATAACATCCGATCAGTTGCATTTCCCTGCATCTCAACAGGCATTTATGGCTTTCCCAACGAGCC
TGCTGCAGTCATTGCCCTCAACACCATTAAGGAATGGCTTGCCAAGAATCACCATGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGA
AGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGA
AGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCAC
TGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGT
GACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCA
GAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGA
CCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATAC
TCCAGGTCCTGATGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAATGACAATCCTCAGCATCGCAAGGCCTCTCCTG
GCTCTGGGGGAGCTCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTGGGGGTGGGGGGAAGGCAAGTCCCATGGAAGGACGGGGAATC
CTTTACTCTAATTTCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAAAAGAAAGAAAAAAAAGAAAAAAAAAGTTTCCTTTAATTTGG
TGGAGGGACCCATGTTGACGCATCTTTCAGGCATTATCCTTGTAATTTCTGTCTTTTCTCTTACAACTTTGCCCCAGGGTCACAGTGGCT
TGATTGAACACTCACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTTATTTCACAAAGCTGGTCACACAGTGGTTTATTCAAAGGAAG
GGGAGGAAGACAGTGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCAATGAGCCCAGCAGCAGTATAATCCCCAGACAGAGGAGGCAG
GATAGAAAATGGGCAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGACAATGAGGTGAAAATATTTTCTTCAGGGTTCCCAAGGCACAA
TTTGTTCCAAGTGGCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGAGCAGAGTGCAGAGGCATAACAGAAGGGTGGGCCCTGGCAGC
CATCTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTTGACACTGACTTTCAGCAGAGCTTACTTGGTTCATGAGGTCT
TCACATGGAGACTACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAAAGGATGGCCCTTTGCTAGGTGTTACAGTTAAAAGCTAAGAA
AAGGGGCAGTGCATTTAGGACCCAAACATATGCCTATGAATATCAAAAGCTCCTCCTGAAATTGCTGTGAGTTTTCCATAAAAGAATATC
CTGTCTTCACCCAAGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAATTACAGGAAATTAGAGCTTTTGCTTGCAGTTCTGCCTTCCTG
GCCTGTGTTTAAATGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATTCAATGGTTGGTCCCCTCACCCAGAAAACCCTGAAGGGGAGG
ATACAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTGGTATAGTGGGCACAAGGGATGGCGACCATGAGGATGCCAGG
CATCATCACCAATATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTACTTCCCACAGCCTCCCCGGGTTCCAAAGTCATGTCATTGTTT
TCAGTGGAAACATATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCTTGTAAGGGCTTTAGAACTAAAACTTACTTATATTGTTTTTC
CTTAACAGAGGGAGAAAAATAGTGGATTATTATTTCTAAAATAAAAGGATGTTCTGCTTTCTAAATATCCCATCAAAATCTTCAGTTTTG
CACTTTTTTGATGGAAAATTCATCTTATCTTCCTATGACTTTGGTTTTAGCCTTTCTGAATTTGTTACCCCTTCTGGATGGCTTATTTGA
TATACTGGAATAGTTAACAAGCTATACTTCAGCATATGCACTATATTCTAACAAATTTTTTTTAATAAAATCAAGACATCAGCAAGAATG
ACATTTACGTGACCTCATAATGTGGGATTATGGCCTTCTGTTGCTATTCCAGTTTGATATGGAAGCATCTATATCCTCTATTGCCGTTAG
ATGTTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATCCAAGAAACGATGTCATCCAAATATTGACAGTTTCTACATTT
CATGCCATCTTTATAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGTATTTGACAAGTGCAATCTGCTAGAAGCTCGTTTTTCTTGTG
ACTCCCAAATGTTAGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAAAAAAACATGAGGGAAACAGAGGGACAGAGATTTTCTAATGA
ACAATGATGGAAGAGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGAAATTATCCAGCCCTGGCATTCTCCTTATCATCAATGACAGT
CATTTTATTCATTTATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGGGAATTCTCTCTGCCTAAAAATTCTAGAAGAATGAAAGTAAT
CTTTGTATCCAGGAAACTAAGAGAATGAGGAATAAATATCTTCAGCCCGACTCCTGAATTTGTTTATTCTTCCATCTATAATTAGATTGT
GTTTTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACAGTTTTATGCTTTAAAACAAATGATAAAGTTAATTTCCAATT
CAATAGTGAAATATTAACAATCTAACTATAGCCAGATCAAAGACACCTGAACACAGAAAACCTTTATTTGCTGGTGCTGCCATTGCACAG
GCTGTACAATGAAATAGATTTGAAAAGCTGATTGATTTTCCCGCACATAAATTCTGGATGTCAATTTCCAACCAAACTCCAATACAGCTA
TGTGGCATGAAGAGTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTAGTCATGTTTGCATACAGAGGATCAAAGTAGGCCTTCACCAT
AATAGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTTTTCCTCTAGCTGGTAACTATTCAGATGATGGACAAGTCTTC
TTTCATAAAAGATTACAAAGAAGGCATCCGAATCACTGTCTGTGATACTGGGTCACATATTAATCACTGCAGCTAATTGTAAATCTTTCT
ATGAAACACTGAAAAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATGCACTTGATTTGAAAAGACATTTCTCTGTATGTGGCGCATGT
CGGCTTTGCTTTGAAAAATAACAAAGTTAGCAGAATATGTTCAATATATTTTCTTGGGGAATAGGGTTTTTATTACATGATTCATTAAGG
ATTTGCCTTACCCTGACATTTGTGATATAAAGGAAAATCAGAAAAAAAGTAATTTTCTTGATCAAGATATGTTTTTACTTAATGCAAATA
AATGTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGGTATAAACTGCTAAATAGGATAATACGTGCCTCTTTTGTTAA
ACCGGCATTTAAATGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCATCTGTGCCATACACTAAAAAACAACTGTTGCCTTCATACTA

>63392_63392_5_PCMTD2-MACROD2_PCMTD2_chr20_62891625_ENST00000369758_MACROD2_chr20_15210586_ENST00000217246_length(amino acids)=430AA_BP=144
MERRCSAADTRGTRPRSCRWQPRRSEPVGRPSLEYCLSVILNMGGAVSAGEDNDELIDNLKEAQYIRTELVEQAFRAIDRADYYLEEFKE
NAYKDLAWKHGNIHLSAPCIYSEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILDVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKEN
NIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEE
KQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEEL

--------------------------------------------------------------
>63392_63392_6_PCMTD2-MACROD2_PCMTD2_chr20_62891625_ENST00000369758_MACROD2_chr20_15210586_ENST00000310348_length(transcript)=1390nt_BP=461nt
CGGCGGCGGATGTTTACGGCGGCCGAGGTTGGAGCGGCGCTGCTCGGCCGCGGACACACGAGGGACGCGCCCGAGGAGCTGCAGGTGGCA
GCCCAGGCGGTCCGAACCCGTCGGCCGGCCGAGCCTGGAGTATTGCCTAAGTGTAATCTTGAACATGGGCGGTGCTGTGAGTGCTGGTGA
AGACAATGATGAGCTGATAGATAATTTGAAAGAAGCACAGTATATCCGGACTGAGCTGGTAGAGCAGGCTTTCAGAGCTATCGATCGTGC
AGACTATTATCTTGAAGAATTTAAAGAAAATGCTTATAAAGACTTGGCATGGAAGCATGGAAACATTCACCTCTCAGCCCCGTGCATCTA
CTCGGAGGTGATGGAAGCCCTAGATCTGCAGCCTGGACTCTCGTTTCTGAACCTGGGCAGTGGCACTGGGTATCTCAGCTCCATGGTGGG
CCTCATTCTAGATGTCATCCATACTGTAGGGCCAATAGCCAGGGGCCATATTAATGGTTCCCACAAGGAAGACCTTGCAAATTGCTATAA
ATCATCTCTGAAGCTCGTGAAAGAAAATAACATCCGATCAGTTGCATTTCCCTGCATCTCAACAGGCATTTATGGCTTTCCCAACGAGCC
TGCTGCAGTCATTGCCCTCAACACCATTAAGGAATGGCTTGCCAAGAATCACCATGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGA
AGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGA
AGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCAC
TGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGT
GACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCA
GAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGA
CCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATAC
TCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGC

>63392_63392_6_PCMTD2-MACROD2_PCMTD2_chr20_62891625_ENST00000369758_MACROD2_chr20_15210586_ENST00000310348_length(amino acids)=454AA_BP=144
MERRCSAADTRGTRPRSCRWQPRRSEPVGRPSLEYCLSVILNMGGAVSAGEDNDELIDNLKEAQYIRTELVEQAFRAIDRADYYLEEFKE
NAYKDLAWKHGNIHLSAPCIYSEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILDVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKEN
NIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEE
KQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEEL
SSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDVEMNSQVDKVNDPTESQQEDQLIAGAQDEAKEQRN

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Fusion Gene PPI Analysis for PCMTD2-MACROD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PCMTD2-MACROD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PCMTD2-MACROD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource