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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGEF7-CRYL1 (FusionGDB2 ID:6344)

Fusion Gene Summary for ARHGEF7-CRYL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF7-CRYL1
Fusion gene ID: 6344
HgeneTgene
Gene symbol

ARHGEF7

CRYL1

Gene ID

8874

51084

Gene nameRho guanine nucleotide exchange factor 7crystallin lambda 1
SynonymsBETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXBGDH|HEL30|gul3DH|lambda-CRY
Cytomap

13q34

13q12.11

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 7PAK-interacting exchange factor betaRho guanine nucleotide exchange factor (GEF) 7SH3 domain-containing proline-rich proteinlambda-crystallin homologL-gulonate 3-dehydrogenasecrystallin, lamda 1epididymis luminal protein 30testicular tissue protein Li 44
Modification date2020032720200313
UniProtAcc

Q14155

Q9Y2S2

Ensembl transtripts involved in fusion geneENST00000317133, ENST00000370623, 
ENST00000375741, ENST00000218789, 
ENST00000375736, ENST00000544132, 
ENST00000375723, ENST00000375737, 
ENST00000375739, ENST00000426073, 
ENST00000478679, ENST00000483189, 
ENST00000480748, ENST00000298248, 
ENST00000382812, 
Fusion gene scores* DoF score25 X 17 X 12=510015 X 9 X 10=1350
# samples 2617
** MAII scorelog2(26/5100*10)=-4.29391371871777
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1350*10)=-2.98935275580049
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGEF7 [Title/Abstract] AND CRYL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF7(111806338)-CRYL1(20987526), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGEF7

GO:0043547

positive regulation of GTPase activity

21048939


check buttonFusion gene breakpoints across ARHGEF7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CRYL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer235NARHGEF7chr13

111806338

+CRYL1chr13

20987526

-


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Fusion Gene ORF analysis for ARHGEF7-CRYL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000317133ENST00000480748ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
5CDS-intronENST00000370623ENST00000480748ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
5CDS-intronENST00000375741ENST00000480748ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
5UTR-3CDSENST00000218789ENST00000298248ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
5UTR-3CDSENST00000218789ENST00000382812ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
5UTR-3CDSENST00000375736ENST00000298248ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
5UTR-3CDSENST00000375736ENST00000382812ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
5UTR-3CDSENST00000544132ENST00000298248ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
5UTR-3CDSENST00000544132ENST00000382812ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
5UTR-intronENST00000218789ENST00000480748ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
5UTR-intronENST00000375736ENST00000480748ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
5UTR-intronENST00000544132ENST00000480748ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
In-frameENST00000317133ENST00000298248ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
In-frameENST00000317133ENST00000382812ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
In-frameENST00000370623ENST00000298248ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
In-frameENST00000370623ENST00000382812ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
In-frameENST00000375741ENST00000298248ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
In-frameENST00000375741ENST00000382812ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-3CDSENST00000375723ENST00000298248ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-3CDSENST00000375723ENST00000382812ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-3CDSENST00000375737ENST00000298248ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-3CDSENST00000375737ENST00000382812ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-3CDSENST00000375739ENST00000298248ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-3CDSENST00000375739ENST00000382812ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-3CDSENST00000426073ENST00000298248ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-3CDSENST00000426073ENST00000382812ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-3CDSENST00000478679ENST00000298248ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-3CDSENST00000478679ENST00000382812ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-3CDSENST00000483189ENST00000298248ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-3CDSENST00000483189ENST00000382812ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-intronENST00000375723ENST00000480748ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-intronENST00000375737ENST00000480748ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-intronENST00000375739ENST00000480748ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-intronENST00000426073ENST00000480748ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-intronENST00000478679ENST00000480748ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-
intron-intronENST00000483189ENST00000480748ARHGEF7chr13

111806338

+CRYL1chr13

20987526

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000317133ARHGEF7chr13111806338+ENST00000298248CRYL1chr1320987526-194911607101486258
ENST00000317133ARHGEF7chr13111806338+ENST00000382812CRYL1chr1320987526-194511607101486258
ENST00000375741ARHGEF7chr13111806338+ENST00000298248CRYL1chr1320987526-129150252828258
ENST00000375741ARHGEF7chr13111806338+ENST00000382812CRYL1chr1320987526-128750252828258
ENST00000370623ARHGEF7chr13111806338+ENST00000298248CRYL1chr1320987526-10412520578192
ENST00000370623ARHGEF7chr13111806338+ENST00000382812CRYL1chr1320987526-10372520578192

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317133ENST00000298248ARHGEF7chr13111806338+CRYL1chr1320987526-0.0113523720.98864764
ENST00000317133ENST00000382812ARHGEF7chr13111806338+CRYL1chr1320987526-0.0111237190.9888763
ENST00000375741ENST00000298248ARHGEF7chr13111806338+CRYL1chr1320987526-0.0078806980.9921193
ENST00000375741ENST00000382812ARHGEF7chr13111806338+CRYL1chr1320987526-0.0078240550.992176
ENST00000370623ENST00000298248ARHGEF7chr13111806338+CRYL1chr1320987526-0.0068802540.9931197
ENST00000370623ENST00000382812ARHGEF7chr13111806338+CRYL1chr1320987526-0.0069097220.99309033

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Fusion Genomic Features for ARHGEF7-CRYL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGEF7-CRYL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:111806338/chr13:20987526)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGEF7

Q14155

CRYL1

Q9Y2S2

FUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000317133+219184_24384783.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000317133+2191_13384783.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000317133+219271_45184783.0DomainDH
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000317133+219473_57884783.0DomainPH
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000370623+219184_24384732.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000370623+2191_13384732.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000370623+219271_45184732.0DomainDH
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000370623+219473_57884732.0DomainPH
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375723+117184_2430626.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375723+1171_1330626.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375723+117271_4510626.0DomainDH
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375723+117473_5780626.0DomainPH
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375736+120184_2430647.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375736+1201_1330647.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375736+120271_4510647.0DomainDH
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375736+120473_5780647.0DomainPH
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375739+118184_2430754.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375739+1181_1330754.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375739+118271_4510754.0DomainDH
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375739+118473_5780754.0DomainPH
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375741+220184_24384804.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375741+2201_13384804.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375741+220271_45184804.0DomainDH
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000375741+220473_57884804.0DomainPH
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000426073+120184_2430647.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000426073+1201_1330647.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000426073+120271_4510647.0DomainDH
HgeneARHGEF7chr13:111806338chr13:20987526ENST00000426073+120473_5780647.0DomainPH
TgeneCRYL1chr13:111806338chr13:20987526ENST000002982484816_17211320.0Nucleotide bindingNAD
TgeneCRYL1chr13:111806338chr13:20987526ENST000003828125916_17189298.0Nucleotide bindingNAD


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Fusion Gene Sequence for ARHGEF7-CRYL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6344_6344_1_ARHGEF7-CRYL1_ARHGEF7_chr13_111806338_ENST00000317133_CRYL1_chr13_20987526_ENST00000298248_length(transcript)=1949nt_BP=1160nt
CCCCGAGACGCAGCCAGGCGCCCGGCCCGGCCCGGCCCGGCCCTCTGCACAGCCCCACTTCAGGCCACGCCGTTTCCTTGACCTTCCCCC
GGCAGGGTCTGAAGCGTCACCGTCCGTCTAGAGCAGAGTCGCGCAGGCCCCTGCCCTGCCGGTGAGGTCGGCGCCGCGCTCCGGAGAGTC
GGTTCCTCCCGATTCAGACCCATATGGCTTCAGATGGAACCATCATTTCTGTTCCGTCATGACCGGCTTGCAAGGTAGCAAAGCGAAACA
AACGTCTCGTTTTCAGCCTGTCCCCGCCACCTTGAAATAAAACCGGCAAAAATAAAAAGAGCATTCTGGGAAGTACTTCATCATTTCAAC
GCTCACGAATTCAAAACATAAACAAAGGCTTCCGAGTGCCCCGGCCAGGGGCGCGGGGCGCACGGCGGGCCCGGGGCAGGTAAGCGCAGG
TGCGCGCCCGCCCCCACCCCCGGCTCCCTCCCCATCCGCTCCCCGCTCCCCTTCCCCTTTCCCTTCCCCGCCCGCTCCCAGCCGCCGCCG
CCGCCCCGCGCACGGCCTGGAGCGGAGGCTGCGCAGGGCGCGGGGCGGCGCGGGCCGGGCGCGGGCCGGGCGGACGGCCGCGTCTTTCTT
CTCCTGGCGGTGATGTCATTGGGCGACGGCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGC
GCCTGACAGCGGGCCGGGGCGCACGGAGAAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGAT
GGGCGAGGCGGCGGCGGCGGCGGCGGGGGCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGG
CCGCAGCGATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGG
AGGGCTTTCTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACC
CCGAGCCCCGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAAGGAATCG
TGTCTCCTAGTGACCTGGACCTTGTCATGTCAGAAGGGTTGGGCATGCGGTATGCATTCATTGGACCCCTGGAAACCATGCATCTCAATG
CAGAAGGTATGTTAAGCTACTGCGACAGATACAGCGAAGGCATAAAACATGTCCTACAGACTTTTGGACCCATTCCAGAGTTTTCCAGGG
CCACTGCTGAGAAGGTTAACCAGGACATGTGCATGAAGGTCCCTGATGACCCGGAGCACTTAGCTGCCAGGAGGCAGTGGAGGGACGAGT
GCCTCATGAGACTCGCCAAGTTGAAGAGTCAAGTGCAGCCCCAGTGAATTTCTTGTAATGCAGCTTCCACTCCTCTCATTGGAGGCCCTA
TTTGGGAACACTGCAAGCCCTTAATCAGCCCTCTGTGACATAGGTAGCAGCCCACGGAGATCCTAAGCTGGCTGTCTTGTGTGCAGCCTG
AGTGGGGTGGTGCAGGCCGGTAGTCTGCCCGTCACTTTGGATCATAGCCCTGGGCCTGGCGGCACAGCAGCACTTGCGTTCTCGGGGCTG
TCGATTTCCTGCCACCTGGGCAGATAACCTGGAGATTTTCACCTTTTCTTTTCAGCTTGATTGCATTTGACTATATTTTACAGCCAGTGA
TTGTAGTTTCATGTTAATATGTGGCAAAATATTTTTGTAATTATTTTCTAATCCCTTTCTGAGTACTCTGGGGCCCTGCATTTATGAGGC

>6344_6344_1_ARHGEF7-CRYL1_ARHGEF7_chr13_111806338_ENST00000317133_CRYL1_chr13_20987526_ENST00000298248_length(amino acids)=258AA_BP=145
MRRRLTAGRGARRSGPGRTCWAAPSQSPAPAARWARRRRRRRGPRAGPPLRGEGARPSPPASRAAAMNSAEQTVTWLITLGVLESPKKTI
SDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLEEGIVSPSDLDLVMSEGLGMRYAFIGPLETM

--------------------------------------------------------------
>6344_6344_2_ARHGEF7-CRYL1_ARHGEF7_chr13_111806338_ENST00000317133_CRYL1_chr13_20987526_ENST00000382812_length(transcript)=1945nt_BP=1160nt
CCCCGAGACGCAGCCAGGCGCCCGGCCCGGCCCGGCCCGGCCCTCTGCACAGCCCCACTTCAGGCCACGCCGTTTCCTTGACCTTCCCCC
GGCAGGGTCTGAAGCGTCACCGTCCGTCTAGAGCAGAGTCGCGCAGGCCCCTGCCCTGCCGGTGAGGTCGGCGCCGCGCTCCGGAGAGTC
GGTTCCTCCCGATTCAGACCCATATGGCTTCAGATGGAACCATCATTTCTGTTCCGTCATGACCGGCTTGCAAGGTAGCAAAGCGAAACA
AACGTCTCGTTTTCAGCCTGTCCCCGCCACCTTGAAATAAAACCGGCAAAAATAAAAAGAGCATTCTGGGAAGTACTTCATCATTTCAAC
GCTCACGAATTCAAAACATAAACAAAGGCTTCCGAGTGCCCCGGCCAGGGGCGCGGGGCGCACGGCGGGCCCGGGGCAGGTAAGCGCAGG
TGCGCGCCCGCCCCCACCCCCGGCTCCCTCCCCATCCGCTCCCCGCTCCCCTTCCCCTTTCCCTTCCCCGCCCGCTCCCAGCCGCCGCCG
CCGCCCCGCGCACGGCCTGGAGCGGAGGCTGCGCAGGGCGCGGGGCGGCGCGGGCCGGGCGCGGGCCGGGCGGACGGCCGCGTCTTTCTT
CTCCTGGCGGTGATGTCATTGGGCGACGGCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGC
GCCTGACAGCGGGCCGGGGCGCACGGAGAAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGAT
GGGCGAGGCGGCGGCGGCGGCGGCGGGGGCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGG
CCGCAGCGATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGG
AGGGCTTTCTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACC
CCGAGCCCCGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAAGGAATCG
TGTCTCCTAGTGACCTGGACCTTGTCATGTCAGAAGGGTTGGGCATGCGGTATGCATTCATTGGACCCCTGGAAACCATGCATCTCAATG
CAGAAGGTATGTTAAGCTACTGCGACAGATACAGCGAAGGCATAAAACATGTCCTACAGACTTTTGGACCCATTCCAGAGTTTTCCAGGG
CCACTGCTGAGAAGGTTAACCAGGACATGTGCATGAAGGTCCCTGATGACCCGGAGCACTTAGCTGCCAGGAGGCAGTGGAGGGACGAGT
GCCTCATGAGACTCGCCAAGTTGAAGAGTCAAGTGCAGCCCCAGTGAATTTCTTGTAATGCAGCTTCCACTCCTCTCATTGGAGGCCCTA
TTTGGGAACACTGCAAGCCCTTAATCAGCCCTCTGTGACATAGGTAGCAGCCCACGGAGATCCTAAGCTGGCTGTCTTGTGTGCAGCCTG
AGTGGGGTGGTGCAGGCCGGTAGTCTGCCCGTCACTTTGGATCATAGCCCTGGGCCTGGCGGCACAGCAGCACTTGCGTTCTCGGGGCTG
TCGATTTCCTGCCACCTGGGCAGATAACCTGGAGATTTTCACCTTTTCTTTTCAGCTTGATTGCATTTGACTATATTTTACAGCCAGTGA
TTGTAGTTTCATGTTAATATGTGGCAAAATATTTTTGTAATTATTTTCTAATCCCTTTCTGAGTACTCTGGGGCCCTGCATTTATGAGGC

>6344_6344_2_ARHGEF7-CRYL1_ARHGEF7_chr13_111806338_ENST00000317133_CRYL1_chr13_20987526_ENST00000382812_length(amino acids)=258AA_BP=145
MRRRLTAGRGARRSGPGRTCWAAPSQSPAPAARWARRRRRRRGPRAGPPLRGEGARPSPPASRAAAMNSAEQTVTWLITLGVLESPKKTI
SDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLEEGIVSPSDLDLVMSEGLGMRYAFIGPLETM

--------------------------------------------------------------
>6344_6344_3_ARHGEF7-CRYL1_ARHGEF7_chr13_111806338_ENST00000370623_CRYL1_chr13_20987526_ENST00000298248_length(transcript)=1041nt_BP=252nt
ATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTT
CTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACCCCGAGCCC
CGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAAGGAATCGTGTCTCCT
AGTGACCTGGACCTTGTCATGTCAGAAGGGTTGGGCATGCGGTATGCATTCATTGGACCCCTGGAAACCATGCATCTCAATGCAGAAGGT
ATGTTAAGCTACTGCGACAGATACAGCGAAGGCATAAAACATGTCCTACAGACTTTTGGACCCATTCCAGAGTTTTCCAGGGCCACTGCT
GAGAAGGTTAACCAGGACATGTGCATGAAGGTCCCTGATGACCCGGAGCACTTAGCTGCCAGGAGGCAGTGGAGGGACGAGTGCCTCATG
AGACTCGCCAAGTTGAAGAGTCAAGTGCAGCCCCAGTGAATTTCTTGTAATGCAGCTTCCACTCCTCTCATTGGAGGCCCTATTTGGGAA
CACTGCAAGCCCTTAATCAGCCCTCTGTGACATAGGTAGCAGCCCACGGAGATCCTAAGCTGGCTGTCTTGTGTGCAGCCTGAGTGGGGT
GGTGCAGGCCGGTAGTCTGCCCGTCACTTTGGATCATAGCCCTGGGCCTGGCGGCACAGCAGCACTTGCGTTCTCGGGGCTGTCGATTTC
CTGCCACCTGGGCAGATAACCTGGAGATTTTCACCTTTTCTTTTCAGCTTGATTGCATTTGACTATATTTTACAGCCAGTGATTGTAGTT
TCATGTTAATATGTGGCAAAATATTTTTGTAATTATTTTCTAATCCCTTTCTGAGTACTCTGGGGCCCTGCATTTATGAGGCACCTACCT

>6344_6344_3_ARHGEF7-CRYL1_ARHGEF7_chr13_111806338_ENST00000370623_CRYL1_chr13_20987526_ENST00000298248_length(amino acids)=192AA_BP=79
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLEEGIVSP
SDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLM

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>6344_6344_4_ARHGEF7-CRYL1_ARHGEF7_chr13_111806338_ENST00000370623_CRYL1_chr13_20987526_ENST00000382812_length(transcript)=1037nt_BP=252nt
ATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTT
CTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACCCCGAGCCC
CGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAAGGAATCGTGTCTCCT
AGTGACCTGGACCTTGTCATGTCAGAAGGGTTGGGCATGCGGTATGCATTCATTGGACCCCTGGAAACCATGCATCTCAATGCAGAAGGT
ATGTTAAGCTACTGCGACAGATACAGCGAAGGCATAAAACATGTCCTACAGACTTTTGGACCCATTCCAGAGTTTTCCAGGGCCACTGCT
GAGAAGGTTAACCAGGACATGTGCATGAAGGTCCCTGATGACCCGGAGCACTTAGCTGCCAGGAGGCAGTGGAGGGACGAGTGCCTCATG
AGACTCGCCAAGTTGAAGAGTCAAGTGCAGCCCCAGTGAATTTCTTGTAATGCAGCTTCCACTCCTCTCATTGGAGGCCCTATTTGGGAA
CACTGCAAGCCCTTAATCAGCCCTCTGTGACATAGGTAGCAGCCCACGGAGATCCTAAGCTGGCTGTCTTGTGTGCAGCCTGAGTGGGGT
GGTGCAGGCCGGTAGTCTGCCCGTCACTTTGGATCATAGCCCTGGGCCTGGCGGCACAGCAGCACTTGCGTTCTCGGGGCTGTCGATTTC
CTGCCACCTGGGCAGATAACCTGGAGATTTTCACCTTTTCTTTTCAGCTTGATTGCATTTGACTATATTTTACAGCCAGTGATTGTAGTT
TCATGTTAATATGTGGCAAAATATTTTTGTAATTATTTTCTAATCCCTTTCTGAGTACTCTGGGGCCCTGCATTTATGAGGCACCTACCT

>6344_6344_4_ARHGEF7-CRYL1_ARHGEF7_chr13_111806338_ENST00000370623_CRYL1_chr13_20987526_ENST00000382812_length(amino acids)=192AA_BP=79
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLEEGIVSP
SDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLM

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>6344_6344_5_ARHGEF7-CRYL1_ARHGEF7_chr13_111806338_ENST00000375741_CRYL1_chr13_20987526_ENST00000298248_length(transcript)=1291nt_BP=502nt
GCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGCGCCTGACAGCGGGCCGGGGCGCACGGAG
AAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGATGGGCGAGGCGGCGGCGGCGGCGGCGGGG
GCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGGCCGCAGCGATGAATTCCGCCGAGCAAAC
CGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTTCTGCAGGCGTCGCTGAAGGA
TGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACCCCGAGCCCCGGAGCGAGAGCGAGTGCCT
GAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAAGGAATCGTGTCTCCTAGTGACCTGGACCTTGTCAT
GTCAGAAGGGTTGGGCATGCGGTATGCATTCATTGGACCCCTGGAAACCATGCATCTCAATGCAGAAGGTATGTTAAGCTACTGCGACAG
ATACAGCGAAGGCATAAAACATGTCCTACAGACTTTTGGACCCATTCCAGAGTTTTCCAGGGCCACTGCTGAGAAGGTTAACCAGGACAT
GTGCATGAAGGTCCCTGATGACCCGGAGCACTTAGCTGCCAGGAGGCAGTGGAGGGACGAGTGCCTCATGAGACTCGCCAAGTTGAAGAG
TCAAGTGCAGCCCCAGTGAATTTCTTGTAATGCAGCTTCCACTCCTCTCATTGGAGGCCCTATTTGGGAACACTGCAAGCCCTTAATCAG
CCCTCTGTGACATAGGTAGCAGCCCACGGAGATCCTAAGCTGGCTGTCTTGTGTGCAGCCTGAGTGGGGTGGTGCAGGCCGGTAGTCTGC
CCGTCACTTTGGATCATAGCCCTGGGCCTGGCGGCACAGCAGCACTTGCGTTCTCGGGGCTGTCGATTTCCTGCCACCTGGGCAGATAAC
CTGGAGATTTTCACCTTTTCTTTTCAGCTTGATTGCATTTGACTATATTTTACAGCCAGTGATTGTAGTTTCATGTTAATATGTGGCAAA
ATATTTTTGTAATTATTTTCTAATCCCTTTCTGAGTACTCTGGGGCCCTGCATTTATGAGGCACCTACCTTCATTTTGCTAACGCTTATT

>6344_6344_5_ARHGEF7-CRYL1_ARHGEF7_chr13_111806338_ENST00000375741_CRYL1_chr13_20987526_ENST00000298248_length(amino acids)=258AA_BP=145
MRRRLTAGRGARRSGPGRTCWAAPSQSPAPAARWARRRRRRRGPRAGPPLRGEGARPSPPASRAAAMNSAEQTVTWLITLGVLESPKKTI
SDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLEEGIVSPSDLDLVMSEGLGMRYAFIGPLETM

--------------------------------------------------------------
>6344_6344_6_ARHGEF7-CRYL1_ARHGEF7_chr13_111806338_ENST00000375741_CRYL1_chr13_20987526_ENST00000382812_length(transcript)=1287nt_BP=502nt
GCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGCGCCTGACAGCGGGCCGGGGCGCACGGAG
AAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGATGGGCGAGGCGGCGGCGGCGGCGGCGGGG
GCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGGCCGCAGCGATGAATTCCGCCGAGCAAAC
CGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTTCTGCAGGCGTCGCTGAAGGA
TGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACCCCGAGCCCCGGAGCGAGAGCGAGTGCCT
GAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAAGGAATCGTGTCTCCTAGTGACCTGGACCTTGTCAT
GTCAGAAGGGTTGGGCATGCGGTATGCATTCATTGGACCCCTGGAAACCATGCATCTCAATGCAGAAGGTATGTTAAGCTACTGCGACAG
ATACAGCGAAGGCATAAAACATGTCCTACAGACTTTTGGACCCATTCCAGAGTTTTCCAGGGCCACTGCTGAGAAGGTTAACCAGGACAT
GTGCATGAAGGTCCCTGATGACCCGGAGCACTTAGCTGCCAGGAGGCAGTGGAGGGACGAGTGCCTCATGAGACTCGCCAAGTTGAAGAG
TCAAGTGCAGCCCCAGTGAATTTCTTGTAATGCAGCTTCCACTCCTCTCATTGGAGGCCCTATTTGGGAACACTGCAAGCCCTTAATCAG
CCCTCTGTGACATAGGTAGCAGCCCACGGAGATCCTAAGCTGGCTGTCTTGTGTGCAGCCTGAGTGGGGTGGTGCAGGCCGGTAGTCTGC
CCGTCACTTTGGATCATAGCCCTGGGCCTGGCGGCACAGCAGCACTTGCGTTCTCGGGGCTGTCGATTTCCTGCCACCTGGGCAGATAAC
CTGGAGATTTTCACCTTTTCTTTTCAGCTTGATTGCATTTGACTATATTTTACAGCCAGTGATTGTAGTTTCATGTTAATATGTGGCAAA
ATATTTTTGTAATTATTTTCTAATCCCTTTCTGAGTACTCTGGGGCCCTGCATTTATGAGGCACCTACCTTCATTTTGCTAACGCTTATT

>6344_6344_6_ARHGEF7-CRYL1_ARHGEF7_chr13_111806338_ENST00000375741_CRYL1_chr13_20987526_ENST00000382812_length(amino acids)=258AA_BP=145
MRRRLTAGRGARRSGPGRTCWAAPSQSPAPAARWARRRRRRRGPRAGPPLRGEGARPSPPASRAAAMNSAEQTVTWLITLGVLESPKKTI
SDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLEEGIVSPSDLDLVMSEGLGMRYAFIGPLETM

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Fusion Gene PPI Analysis for ARHGEF7-CRYL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF7-CRYL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF7-CRYL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource