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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PCSK5-RAB3IP (FusionGDB2 ID:63522)

Fusion Gene Summary for PCSK5-RAB3IP

check button Fusion gene summary
Fusion gene informationFusion gene name: PCSK5-RAB3IP
Fusion gene ID: 63522
HgeneTgene
Gene symbol

PCSK5

RAB3IP

Gene ID

5125

117177

Gene nameproprotein convertase subtilisin/kexin type 5RAB3A interacting protein
SynonymsPC5|PC6|PC6A|SPC6RABIN3|RABIN8
Cytomap

9q21.13

12q15

Type of geneprotein-codingprotein-coding
Descriptionproprotein convertase subtilisin/kexin type 5prohormone convertase 5proprotein convertase 6protease PC6subtilasesubtilisin/kexin-like protease PC5rab-3A-interacting proteinSSX2 interacting proteinrab3A-interacting proteinrabin-3
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000376752, ENST00000376767, 
ENST00000545128, 		ENST00000325555, 
ENST00000362025, ENST00000483530, 
ENST00000550536, ENST00000551641, 
ENST00000553099, ENST00000550847, 
ENST00000247833, ENST00000378815, 
Fusion gene scores* DoF score10 X 8 X 8=64020 X 17 X 10=3400
# samples 1229
** MAII scorelog2(12/640*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/3400*10)=-3.55140994101013
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCSK5 [Title/Abstract] AND RAB3IP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPCSK5(78506289)-RAB3IP(70178500), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePCSK5

GO:0006465

signal peptide processing

16912035

HgenePCSK5

GO:0016485

protein processing

8901832|15606899

HgenePCSK5

GO:0016486

peptide hormone processing

8901832

HgenePCSK5

GO:0043043

peptide biosynthetic process

8901832

TgeneRAB3IP

GO:0006612

protein targeting to membrane

23382462


check buttonFusion gene breakpoints across PCSK5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAB3IP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6BE-01APCSK5chr9

78506289

+RAB3IPchr12

70178500

+
ChimerDB4SARCTCGA-WK-A8Y0-01APCSK5chr9

78506289

+RAB3IPchr12

70178500

+
ChimerDB4SARCTCGA-WK-A8Y0-01APCSK5chr9

78506289

+RAB3IPchr12

70188217

+


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Fusion Gene ORF analysis for PCSK5-RAB3IP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000376752ENST00000325555PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000376752ENST00000325555PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000376752ENST00000362025PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000376752ENST00000362025PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000376752ENST00000483530PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000376752ENST00000483530PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000376752ENST00000550536PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000376752ENST00000550536PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000376752ENST00000551641PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000376752ENST00000551641PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000376752ENST00000553099PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000376752ENST00000553099PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000376767ENST00000325555PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000376767ENST00000325555PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000376767ENST00000362025PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000376767ENST00000362025PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000376767ENST00000483530PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000376767ENST00000483530PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000376767ENST00000550536PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000376767ENST00000550536PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000376767ENST00000551641PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000376767ENST00000551641PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000376767ENST00000553099PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000376767ENST00000553099PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000545128ENST00000325555PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000545128ENST00000325555PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000545128ENST00000362025PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000545128ENST00000362025PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000545128ENST00000483530PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000545128ENST00000483530PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000545128ENST00000550536PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000545128ENST00000550536PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000545128ENST00000551641PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000545128ENST00000551641PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-5UTRENST00000545128ENST00000553099PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-5UTRENST00000545128ENST00000553099PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-intronENST00000376752ENST00000550847PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-intronENST00000376752ENST00000550847PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-intronENST00000376767ENST00000550847PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-intronENST00000376767ENST00000550847PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
5CDS-intronENST00000545128ENST00000550847PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
5CDS-intronENST00000545128ENST00000550847PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
In-frameENST00000376752ENST00000247833PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
In-frameENST00000376752ENST00000247833PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
In-frameENST00000376752ENST00000378815PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
In-frameENST00000376752ENST00000378815PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
In-frameENST00000376767ENST00000247833PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
In-frameENST00000376767ENST00000247833PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
In-frameENST00000376767ENST00000378815PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
In-frameENST00000376767ENST00000378815PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
In-frameENST00000545128ENST00000247833PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
In-frameENST00000545128ENST00000247833PCSK5chr9

78506289

+RAB3IPchr12

70188217

+
In-frameENST00000545128ENST00000378815PCSK5chr9

78506289

+RAB3IPchr12

70178500

+
In-frameENST00000545128ENST00000378815PCSK5chr9

78506289

+RAB3IPchr12

70188217

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545128PCSK5chr978506289+ENST00000247833RAB3IPchr1270178500+35347304751602375
ENST00000545128PCSK5chr978506289+ENST00000378815RAB3IPchr1270178500+24117304751167230
ENST00000376767PCSK5chr978506289+ENST00000247833RAB3IPchr1270178500+35087044491576375
ENST00000376767PCSK5chr978506289+ENST00000378815RAB3IPchr1270178500+23857044491141230
ENST00000376752PCSK5chr978506289+ENST00000247833RAB3IPchr1270178500+34736694141541375
ENST00000376752PCSK5chr978506289+ENST00000378815RAB3IPchr1270178500+23506694141106230
ENST00000545128PCSK5chr978506289+ENST00000247833RAB3IPchr1270188217+34387304751506343
ENST00000545128PCSK5chr978506289+ENST00000378815RAB3IPchr1270188217+23157304751071198
ENST00000376767PCSK5chr978506289+ENST00000247833RAB3IPchr1270188217+34127044491480343
ENST00000376767PCSK5chr978506289+ENST00000378815RAB3IPchr1270188217+22897044491045198
ENST00000376752PCSK5chr978506289+ENST00000247833RAB3IPchr1270188217+33776694141445343
ENST00000376752PCSK5chr978506289+ENST00000378815RAB3IPchr1270188217+22546694141010198

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545128ENST00000247833PCSK5chr978506289+RAB3IPchr1270178500+0.0001653330.99983466
ENST00000545128ENST00000378815PCSK5chr978506289+RAB3IPchr1270178500+0.0176859520.982314
ENST00000376767ENST00000247833PCSK5chr978506289+RAB3IPchr1270178500+0.0001522170.99984777
ENST00000376767ENST00000378815PCSK5chr978506289+RAB3IPchr1270178500+0.014206810.9857932
ENST00000376752ENST00000247833PCSK5chr978506289+RAB3IPchr1270178500+0.0001427790.9998572
ENST00000376752ENST00000378815PCSK5chr978506289+RAB3IPchr1270178500+0.0126071410.98739284
ENST00000545128ENST00000247833PCSK5chr978506289+RAB3IPchr1270188217+0.000388430.99961156
ENST00000545128ENST00000378815PCSK5chr978506289+RAB3IPchr1270188217+0.096191950.9038081
ENST00000376767ENST00000247833PCSK5chr978506289+RAB3IPchr1270188217+0.000355860.99964416
ENST00000376767ENST00000378815PCSK5chr978506289+RAB3IPchr1270188217+0.077280780.9227192
ENST00000376752ENST00000247833PCSK5chr978506289+RAB3IPchr1270188217+0.0003331730.9996668
ENST00000376752ENST00000378815PCSK5chr978506289+RAB3IPchr1270188217+0.091782320.90821767

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Fusion Genomic Features for PCSK5-RAB3IP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PCSK5chr978506289+RAB3IPchr1270178499+8.21E-050.999918
PCSK5chr978506289+RAB3IPchr1270178499+8.21E-050.999918
PCSK5chr978506289+RAB3IPchr1270188216+5.20E-050.999948
PCSK5chr978506289+RAB3IPchr1270178499+8.21E-050.999918
PCSK5chr978506289+RAB3IPchr1270178499+8.21E-050.999918
PCSK5chr978506289+RAB3IPchr1270188216+5.20E-050.999948

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PCSK5-RAB3IP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:78506289/chr12:70178500)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211812_185364914.0Compositional biasNote=Asp-rich
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371812_1853641861.0Compositional biasNote=Asp-rich
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211812_185364914.0Compositional biasNote=Asp-rich
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371812_1853641861.0Compositional biasNote=Asp-rich
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121134_45364914.0DomainPeptidase S8
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121461_60164914.0DomainP/Homo B
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121869_91364914.0DomainNote=PLAC
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137134_453641861.0DomainPeptidase S8
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137461_601641861.0DomainP/Homo B
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137869_913641861.0DomainNote=PLAC
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121134_45364914.0DomainPeptidase S8
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121461_60164914.0DomainP/Homo B
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121869_91364914.0DomainNote=PLAC
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137134_453641861.0DomainPeptidase S8
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137461_601641861.0DomainP/Homo B
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137869_913641861.0DomainNote=PLAC
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121519_52164914.0MotifCell attachment site
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137519_521641861.0MotifCell attachment site
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121519_52164914.0MotifCell attachment site
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137519_521641861.0MotifCell attachment site
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211807_182664914.0RegionAC 1
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211838_186064914.0RegionAC 2
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121636_172764914.0RegionNote=CRM (Cys-rich motif)
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371807_1826641861.0RegionAC 1
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371838_1860641861.0RegionAC 2
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137636_1727641861.0RegionNote=CRM (Cys-rich motif)
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211807_182664914.0RegionAC 1
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211838_186064914.0RegionAC 2
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121636_172764914.0RegionNote=CRM (Cys-rich motif)
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371807_1826641861.0RegionAC 1
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371838_1860641861.0RegionAC 2
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137636_1727641861.0RegionNote=CRM (Cys-rich motif)
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211032_107764914.0RepeatNote=FU 9
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211079_112164914.0RepeatNote=FU 10
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211125_116864914.0RepeatNote=FU 11
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211177_122164914.0RepeatNote=FU 12
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211225_127264914.0RepeatNote=FU 13
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211274_131864914.0RepeatNote=FU 14
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211320_136364914.0RepeatNote=FU 15
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211365_141164914.0RepeatNote=FU 16
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211415_146164914.0RepeatNote=FU 17
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211465_151064914.0RepeatNote=FU 18
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211514_155964914.0RepeatNote=FU 19
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211563_161064914.0RepeatNote=FU 20
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211614_165964914.0RepeatNote=FU 21
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211665_171264914.0RepeatNote=FU 22
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121630_68064914.0RepeatNote=FU 1
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121683_73064914.0RepeatNote=FU 2
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121734_77764914.0RepeatNote=FU 3
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121779_82464914.0RepeatNote=FU 4
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121832_87964914.0RepeatNote=FU 5
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121882_92764914.0RepeatNote=FU 6
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121929_97964914.0RepeatNote=FU 7
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121982_102864914.0RepeatNote=FU 8
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371032_1077641861.0RepeatNote=FU 9
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371079_1121641861.0RepeatNote=FU 10
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371125_1168641861.0RepeatNote=FU 11
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371177_1221641861.0RepeatNote=FU 12
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371225_1272641861.0RepeatNote=FU 13
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371274_1318641861.0RepeatNote=FU 14
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371320_1363641861.0RepeatNote=FU 15
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371365_1411641861.0RepeatNote=FU 16
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371415_1461641861.0RepeatNote=FU 17
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371465_1510641861.0RepeatNote=FU 18
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371514_1559641861.0RepeatNote=FU 19
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371563_1610641861.0RepeatNote=FU 20
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371614_1659641861.0RepeatNote=FU 21
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371665_1712641861.0RepeatNote=FU 22
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137630_680641861.0RepeatNote=FU 1
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137683_730641861.0RepeatNote=FU 2
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137734_777641861.0RepeatNote=FU 3
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137779_824641861.0RepeatNote=FU 4
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137832_879641861.0RepeatNote=FU 5
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137882_927641861.0RepeatNote=FU 6
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137929_979641861.0RepeatNote=FU 7
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137982_1028641861.0RepeatNote=FU 8
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211032_107764914.0RepeatNote=FU 9
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211079_112164914.0RepeatNote=FU 10
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211125_116864914.0RepeatNote=FU 11
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211177_122164914.0RepeatNote=FU 12
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211225_127264914.0RepeatNote=FU 13
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211274_131864914.0RepeatNote=FU 14
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211320_136364914.0RepeatNote=FU 15
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211365_141164914.0RepeatNote=FU 16
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211415_146164914.0RepeatNote=FU 17
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211465_151064914.0RepeatNote=FU 18
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211514_155964914.0RepeatNote=FU 19
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211563_161064914.0RepeatNote=FU 20
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211614_165964914.0RepeatNote=FU 21
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211665_171264914.0RepeatNote=FU 22
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121630_68064914.0RepeatNote=FU 1
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121683_73064914.0RepeatNote=FU 2
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121734_77764914.0RepeatNote=FU 3
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121779_82464914.0RepeatNote=FU 4
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121832_87964914.0RepeatNote=FU 5
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121882_92764914.0RepeatNote=FU 6
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121929_97964914.0RepeatNote=FU 7
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121982_102864914.0RepeatNote=FU 8
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371032_1077641861.0RepeatNote=FU 9
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371079_1121641861.0RepeatNote=FU 10
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371125_1168641861.0RepeatNote=FU 11
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371177_1221641861.0RepeatNote=FU 12
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371225_1272641861.0RepeatNote=FU 13
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371274_1318641861.0RepeatNote=FU 14
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371320_1363641861.0RepeatNote=FU 15
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371365_1411641861.0RepeatNote=FU 16
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371415_1461641861.0RepeatNote=FU 17
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371465_1510641861.0RepeatNote=FU 18
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371514_1559641861.0RepeatNote=FU 19
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371563_1610641861.0RepeatNote=FU 20
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371614_1659641861.0RepeatNote=FU 21
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371665_1712641861.0RepeatNote=FU 22
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137630_680641861.0RepeatNote=FU 1
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137683_730641861.0RepeatNote=FU 2
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137734_777641861.0RepeatNote=FU 3
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137779_824641861.0RepeatNote=FU 4
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137832_879641861.0RepeatNote=FU 5
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137882_927641861.0RepeatNote=FU 6
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137929_979641861.0RepeatNote=FU 7
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137982_1028641861.0RepeatNote=FU 8
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121115_174364914.0Topological domainExtracellular
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211765_186064914.0Topological domainCytoplasmic
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137115_1743641861.0Topological domainExtracellular
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371765_1860641861.0Topological domainCytoplasmic
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121115_174364914.0Topological domainExtracellular
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211765_186064914.0Topological domainCytoplasmic
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137115_1743641861.0Topological domainExtracellular
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371765_1860641861.0Topological domainCytoplasmic
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211744_176464914.0TransmembraneHelical
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371744_1764641861.0TransmembraneHelical
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211744_176464914.0TransmembraneHelical
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371744_1764641861.0TransmembraneHelical


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Fusion Gene Sequence for PCSK5-RAB3IP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63522_63522_1_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376752_RAB3IP_chr12_70178500_ENST00000247833_length(transcript)=3473nt_BP=669nt
CGGAGGGAGCGCTGGGAGCGAGCAAGCGAGCGTTTGGAGCCCGGGCCAGCAGAGGGGGCGCCCGGTCGCTGCCTGTACCGCTCCCGCTGG
TCATCTCCGCCGCGCTCGGGGGCCCCGGGAGGAGCGAGACCGAGTCGGAGAGTCCGGGAGCCAAGCCGGGCGAAACCCAACTGCGGAGGA
CGCCCGCCCCACTCAGCCTCCTCCTGCGTCCGAGCCGGGGAGCATCGCCGAGCGCCCCACGGGCCGGAGAGCTGGGAGCACAGGTCCCGG
CAGCCCCAGGGATGGTCTAGGAGCCGGCGTAAGGCTCGCTGCTCTGCTCCCTGCCGGGGCTAGCCGCCTCCTGCCGATCGCCCGGGGCTG
CGAGCTGCGGCGGCCCGGGGCTGCTCGCCGGGCGGCGCAGGCCGGAGAAGTTAGTTGTGCGCGCCCTTAGTGCGCGGAACCAGCCAGCGA
GCGAGGGAGCAGCGAGGCGCCGGGACCATGGGCTGGGGGAGCCGCTGCTGCTGCCCGGGACGTTTGGACCTGCTGTGCGTGCTGGCGCTG
CTCGGGGGCTGCCTGCTCCCCGTGTGTCGGACGCGCGTCTACACCAACCACTGGGCAGTCAAAATCGCCGGGGGCTTCCCGGAGGCCAAC
CGTATCGCCAGCAAGTACGGATTCATCAACATAGGACAGGAACTGAAGTTAAAAGATGAAGAATGTGAGAGGCTTTCAAAAGTGCGAGAT
CAACTTGGACAGGAATTGGAAGAACTCACAGCTAGTCTATTTGAGGAAGCTCATAAAATGGTGAGAGAAGCAAATATCAAGCAGGCAACA
GCAGAAAAACAGCTAAAAGAAGCACAAGGAAAAATTGATGTACTTCAAGCTGAAGTAGCTGCATTGAAGACACTTGTATTGTCCAGTTCT
CCAACATCACCTACGCAGGAGCCTTTGCCAGGTGGAAAGACACCTTTTAAAAAGGGGCATACAAGAAATAAAAGCACAAGCAGTGCTATG
AGTGGCAGTCATCAGGACCTCAGTGTGATACAGCCAATTGTAAAAGACTGCAAAGAGGCTGACTTATCCTTGTATAATGAATTCCGATTG
TGGAAGGATGAGCCCACAATGGACAGGACGTGTCCTTTCTTAGACAAAATCTACCAGGAAGATATCTTTCCATGTTTAACATTCTCAAAA
AGTGAGTTGGCTTCAGCTGTTCTGGAGGCTGTGGAAAACAATACTCTAAGCATTGAACCAGTGGGATTACAACCTATCCGGTTTGTGAAA
GCTTCTGCAGTTGAATGCGGAGGACCAAAAAAATGTGCTCTCACTGGCCAGAGTAAGTCCTGTAAACACAGAATTAAATTAGGGGACTCA
AGCAACTATTATTATATTTCTCCTTTTTGCAGATACAGGATCACTTCTGTATGTAACTTTTTTACATACATTCGATACATTCAGCAGGGA
CTCGTGAAACAGCAGGATGTTGATCAGATGTTTTGGGAGGTTATGCAGTTGAGAAAAGAGATGTCATTGGCAAAGCTGGGTTATTTCAAA
GAGGAACTCTGATGCTCTGCGTGGGACCATGCCTGAACTCCCCGAATAACTGAAAAATGGCTGAATATTTTTATGGTTACTTGATATTTA
TTTCCAAGGAGTGAGCCTAAGACTTTTTTCCCCTTTTGCAAATTGCTCTAAGAAGTACCATGATTTCTTTTAAACTGATCTATGCTGTGT
TTGCTTATTCTTTAGTTGAACACACTATGAAGAATTCCAGGTGTACTAGTGAATGTAATTTATAGTTGCCAAAAAAAAAAAAAACCTGAA
ATAAATAAATGTTAGATTGAATGTGTGTACATTTTCTCTTCTAGCTCTGACATGGCATTTAGGGTTAGCAGAATGTATTAAATAGTAATT
TTCAAACTACACAGTAGCTTCCTTCCTTGTGAGAGGCAAGAAAGAAGTCTGAGTGGATAGTACTCACTTTCCAAGGCCCCCACCTCTAGA
ATGGCTTTATTTTTATCTGTTTTCTATATTGGGTTTCAAAAAAGATTTTATTTGAAGAAATACTTCTGCTGCTACAAAGTTTGAAAGTTA
CTATTTTAATTATTCTGCTCTCTGTAACTGAAAGAATCCCTTTATTTTGGTTATTCATTAAAATATAATAGAAGGCAGTCAGATTTTATC
CCAGAGATGTATTCCTGAGTGTCTTGATATAGTGTATTCATGTTTTATATGTGTTGACCACTATATTGTCATTGGAGGGACATAGATGTA
AATGAGTTTGACGTGTGTCAAAGGGGTTTAAAGGGGTGTGGATTGAATGAATGGTACGTGCGAAGTATATGCTGATTATAGAACCACTTG
ATCTCTGCATTCCAAATTGTAAAACTGACTCAACTGGAGAAATTATAACAAAGAGGTTTGTGGTAGACATGTAATAAGTATAGAAAAGCA
AAAAGAAAAGAGAAACTGCTTTAGTTTCTGTTTAGAGAAAGCTGCTGTTAATATTTTTGGATAGTAGCCTTTCAGCTTTCAGATATTTTC
TACTTACATATGCATATTTTTGAAACAAAAAGTAGGCTTTTTTTTTGCTTTTTAAACCTAAACATTAAATATATTTTCCCTTGGGTAAAC
CTACACATCCTAATCCCTGTTTATAGAATTTTAACATAATTTAATTGTGTTTGGAGATGAGGTGGTTTTCAGTTTATTTTTCATATTATA
ATGCTGTGACGAGTATCCTTATCTGTACACTTCTGAACATTGTGGAGTTCTTTCATGTGGATGCCTGGAGATAAAATTGTGTCGAGATAT
ATATGTATTTTTAAATGTTTGATCTGCATTGCTAGATTGCCATCCAGAAAAGTTAATCAATTTGTATTCACAGCAGCAGTGTACAAGAGG
GCTGGTTTTCTGAAGATAACATTTTTTTCAGTCCTGTTCAGAGGTTTGGTCAATCTTACCTGTAGATGACTTCAGCCACCAGGCTGGATG
GGAGCCCACAGACAAAAGGACATTGGTGTATGTTATGGTGAAAACCATCAGTACCATGCCTAGCTCAAGAATGTGAAATTGAACCTGAAA
AAAACTTTGAACCTACAATTTTATGTTCTGAAAATAGTTATTCTAATGTGAGGGCATTAATAAGAATATGTACCATCAAAGCTTCAGAAG
ATTTTCCGTACAAACTAAAATCACTTTTGGAGAAAGTACCTAAATAAAAAGAGAAACAAATCCAGGAGATACTGTACGGTTTGAAAGAAA
GGTAATCAAATACTCAGAAAAAGTTTGTTGATGACTTAAAAAGGATAAATAAAAAGTAAGACTAAAGAAAATCAGTATACCCATTAATAA
TAAATCTTTAGTAATCTATAAGGGGAAGAATGCTTTTCAACCTTATACACTAGAAGCATGCTCTTTAAAATTAATGCAACAGGATGACGA

>63522_63522_1_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376752_RAB3IP_chr12_70178500_ENST00000247833_length(amino acids)=375AA_BP=80
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQELKLK
DEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKK
GHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEADLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSI
EPVGLQPIRFVKASAVECGGPKKCALTGQSKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLR

--------------------------------------------------------------
>63522_63522_2_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376752_RAB3IP_chr12_70178500_ENST00000378815_length(transcript)=2350nt_BP=669nt
CGGAGGGAGCGCTGGGAGCGAGCAAGCGAGCGTTTGGAGCCCGGGCCAGCAGAGGGGGCGCCCGGTCGCTGCCTGTACCGCTCCCGCTGG
TCATCTCCGCCGCGCTCGGGGGCCCCGGGAGGAGCGAGACCGAGTCGGAGAGTCCGGGAGCCAAGCCGGGCGAAACCCAACTGCGGAGGA
CGCCCGCCCCACTCAGCCTCCTCCTGCGTCCGAGCCGGGGAGCATCGCCGAGCGCCCCACGGGCCGGAGAGCTGGGAGCACAGGTCCCGG
CAGCCCCAGGGATGGTCTAGGAGCCGGCGTAAGGCTCGCTGCTCTGCTCCCTGCCGGGGCTAGCCGCCTCCTGCCGATCGCCCGGGGCTG
CGAGCTGCGGCGGCCCGGGGCTGCTCGCCGGGCGGCGCAGGCCGGAGAAGTTAGTTGTGCGCGCCCTTAGTGCGCGGAACCAGCCAGCGA
GCGAGGGAGCAGCGAGGCGCCGGGACCATGGGCTGGGGGAGCCGCTGCTGCTGCCCGGGACGTTTGGACCTGCTGTGCGTGCTGGCGCTG
CTCGGGGGCTGCCTGCTCCCCGTGTGTCGGACGCGCGTCTACACCAACCACTGGGCAGTCAAAATCGCCGGGGGCTTCCCGGAGGCCAAC
CGTATCGCCAGCAAGTACGGATTCATCAACATAGGACAGGAACTGAAGTTAAAAGATGAAGAATGTGAGAGGCTTTCAAAAGTGCGAGAT
CAACTTGGACAGGAATTGGAAGAACTCACAGCTAGTCTATTTGAGGAAGCTCATAAAATGGTGAGAGAAGCAAATATCAAGCAGGCAACA
GCAGAAAAACAGCTAAAAGAAGCACAAGGAAAAATTGATGTACTTCAAGCTGAAGTAGCTGCATTGAAGACACTTGTATTGTCCAGTTCT
CCAACATCACCTACGCAGGAGCCTTTGCCAGGTGGAAAGACACCTTTTAAAAAGGGGCATACAAGAAATAAAAGCACAAGCAGTGCTATG
AGTGGCAGTCATCAGGACCTCAGTGTGATACAGCCAATTGTAAAAGACTGCAAAGAGGTAACTCATCAAGGACTGTCCCCTCTGACTCTG
TTGATACTTGTTAGTTCTCATCACTGAGGTGTCAGTTATCATTTTTGCCAGCAAAATTTTTAGTACAAAATAATGCAGTATTAAGATGGG
GGAGGCTTTATCTAGAGCTGGCTGCTTTCAGGGATTCTTCAGTTCCATTTTCTACCTGGCTGACCTTGGAGTACCTGCTGGAAACTTGGT
AAGTTTCTTAATCTCAGTATTTCATTAAGGGAGGAAACTGTCATGTGTTGTCTAGAGGAGAGTGGGTGGCTTTAATGATCTGGCTAGTCA
AAATTTATTGCTAGAGTGCGCTTACAAAGTATGGATATAAGAAATATGTGAAAATAAGATGATTTTCTTAAAGATCAATACATTGCTTTT
ATTTAAATTCAGAGAGAATTTTATGTCAGCAAGGGAGTCCTAGAGTTAATTTAGATAATTAAGCAACAAAAAAATAGAAATAATGGTAGC
CTTACAATGACATAAGGCTGGAAGACATTTTGCTAAGTGAAATTTCAAGTTATAGTAGAACAATTAGTGTCATTTTTGATCCCAAATTAG
GTTTCACAGTTCAGCCAGTCTGTTATTCAGACACTTACAACTATGTAAGGCCACCATTATCATGTATCCATAACAATTAAAAATTTAAAA
ACGAAATAATGGGCCGGGCATGGTGGCTCATGCCTGTAATCTCAGCACTTTGGGAGGCCAAGGCCGGAGGATCACCTGAGGTTGGGAGTT
CGAGACCAGCCTGACCAACATGGAGAAACCCTATCTGTACTAAAAATATAAAATTAGCTGGGCATGGTATCTCATGCTTATAATCCCAGC
TACTCAGGAGGCTGAGGCAGGAGAATCCCTTGAACCTGGGAGGCGGAGGTTGCGGTCAGCTGAGATTGCGCCATCACACTCCAGCCTGGG
CAACAAGAGCGAAACTCTGTCTCAAAATCATAATAATAATAATAGTCTTATTTTAAAAGATATGTTACAAAGATAACTGAAATAATATAT
AAATATTTTGAGCTGTTTAGAGTAAAAATTTTTAATCATTGTATACTGTGAGAATGCATTTCTAAGAGGATTGATCAATAATTTATGAAG
CTTTCCCATTTCTTCTTAGAAGCCATCTTTTACATTGTTAAATTCAAGTCCATCATTAATCTTGAAGAAATGTGTGTGCTTGTTAAATTT
TTGTATGGAAGCCAGGAGTTTATTAAATGGAATAACCAATGTTAACCTGTTTTAATTGAATTGCATTTTGACGAATTATCAATAAAAATG

>63522_63522_2_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376752_RAB3IP_chr12_70178500_ENST00000378815_length(amino acids)=230AA_BP=80
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQELKLK
DEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKK

--------------------------------------------------------------
>63522_63522_3_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376752_RAB3IP_chr12_70188217_ENST00000247833_length(transcript)=3377nt_BP=669nt
CGGAGGGAGCGCTGGGAGCGAGCAAGCGAGCGTTTGGAGCCCGGGCCAGCAGAGGGGGCGCCCGGTCGCTGCCTGTACCGCTCCCGCTGG
TCATCTCCGCCGCGCTCGGGGGCCCCGGGAGGAGCGAGACCGAGTCGGAGAGTCCGGGAGCCAAGCCGGGCGAAACCCAACTGCGGAGGA
CGCCCGCCCCACTCAGCCTCCTCCTGCGTCCGAGCCGGGGAGCATCGCCGAGCGCCCCACGGGCCGGAGAGCTGGGAGCACAGGTCCCGG
CAGCCCCAGGGATGGTCTAGGAGCCGGCGTAAGGCTCGCTGCTCTGCTCCCTGCCGGGGCTAGCCGCCTCCTGCCGATCGCCCGGGGCTG
CGAGCTGCGGCGGCCCGGGGCTGCTCGCCGGGCGGCGCAGGCCGGAGAAGTTAGTTGTGCGCGCCCTTAGTGCGCGGAACCAGCCAGCGA
GCGAGGGAGCAGCGAGGCGCCGGGACCATGGGCTGGGGGAGCCGCTGCTGCTGCCCGGGACGTTTGGACCTGCTGTGCGTGCTGGCGCTG
CTCGGGGGCTGCCTGCTCCCCGTGTGTCGGACGCGCGTCTACACCAACCACTGGGCAGTCAAAATCGCCGGGGGCTTCCCGGAGGCCAAC
CGTATCGCCAGCAAGTACGGATTCATCAACATAGGACAGGAAGCTCATAAAATGGTGAGAGAAGCAAATATCAAGCAGGCAACAGCAGAA
AAACAGCTAAAAGAAGCACAAGGAAAAATTGATGTACTTCAAGCTGAAGTAGCTGCATTGAAGACACTTGTATTGTCCAGTTCTCCAACA
TCACCTACGCAGGAGCCTTTGCCAGGTGGAAAGACACCTTTTAAAAAGGGGCATACAAGAAATAAAAGCACAAGCAGTGCTATGAGTGGC
AGTCATCAGGACCTCAGTGTGATACAGCCAATTGTAAAAGACTGCAAAGAGGCTGACTTATCCTTGTATAATGAATTCCGATTGTGGAAG
GATGAGCCCACAATGGACAGGACGTGTCCTTTCTTAGACAAAATCTACCAGGAAGATATCTTTCCATGTTTAACATTCTCAAAAAGTGAG
TTGGCTTCAGCTGTTCTGGAGGCTGTGGAAAACAATACTCTAAGCATTGAACCAGTGGGATTACAACCTATCCGGTTTGTGAAAGCTTCT
GCAGTTGAATGCGGAGGACCAAAAAAATGTGCTCTCACTGGCCAGAGTAAGTCCTGTAAACACAGAATTAAATTAGGGGACTCAAGCAAC
TATTATTATATTTCTCCTTTTTGCAGATACAGGATCACTTCTGTATGTAACTTTTTTACATACATTCGATACATTCAGCAGGGACTCGTG
AAACAGCAGGATGTTGATCAGATGTTTTGGGAGGTTATGCAGTTGAGAAAAGAGATGTCATTGGCAAAGCTGGGTTATTTCAAAGAGGAA
CTCTGATGCTCTGCGTGGGACCATGCCTGAACTCCCCGAATAACTGAAAAATGGCTGAATATTTTTATGGTTACTTGATATTTATTTCCA
AGGAGTGAGCCTAAGACTTTTTTCCCCTTTTGCAAATTGCTCTAAGAAGTACCATGATTTCTTTTAAACTGATCTATGCTGTGTTTGCTT
ATTCTTTAGTTGAACACACTATGAAGAATTCCAGGTGTACTAGTGAATGTAATTTATAGTTGCCAAAAAAAAAAAAAACCTGAAATAAAT
AAATGTTAGATTGAATGTGTGTACATTTTCTCTTCTAGCTCTGACATGGCATTTAGGGTTAGCAGAATGTATTAAATAGTAATTTTCAAA
CTACACAGTAGCTTCCTTCCTTGTGAGAGGCAAGAAAGAAGTCTGAGTGGATAGTACTCACTTTCCAAGGCCCCCACCTCTAGAATGGCT
TTATTTTTATCTGTTTTCTATATTGGGTTTCAAAAAAGATTTTATTTGAAGAAATACTTCTGCTGCTACAAAGTTTGAAAGTTACTATTT
TAATTATTCTGCTCTCTGTAACTGAAAGAATCCCTTTATTTTGGTTATTCATTAAAATATAATAGAAGGCAGTCAGATTTTATCCCAGAG
ATGTATTCCTGAGTGTCTTGATATAGTGTATTCATGTTTTATATGTGTTGACCACTATATTGTCATTGGAGGGACATAGATGTAAATGAG
TTTGACGTGTGTCAAAGGGGTTTAAAGGGGTGTGGATTGAATGAATGGTACGTGCGAAGTATATGCTGATTATAGAACCACTTGATCTCT
GCATTCCAAATTGTAAAACTGACTCAACTGGAGAAATTATAACAAAGAGGTTTGTGGTAGACATGTAATAAGTATAGAAAAGCAAAAAGA
AAAGAGAAACTGCTTTAGTTTCTGTTTAGAGAAAGCTGCTGTTAATATTTTTGGATAGTAGCCTTTCAGCTTTCAGATATTTTCTACTTA
CATATGCATATTTTTGAAACAAAAAGTAGGCTTTTTTTTTGCTTTTTAAACCTAAACATTAAATATATTTTCCCTTGGGTAAACCTACAC
ATCCTAATCCCTGTTTATAGAATTTTAACATAATTTAATTGTGTTTGGAGATGAGGTGGTTTTCAGTTTATTTTTCATATTATAATGCTG
TGACGAGTATCCTTATCTGTACACTTCTGAACATTGTGGAGTTCTTTCATGTGGATGCCTGGAGATAAAATTGTGTCGAGATATATATGT
ATTTTTAAATGTTTGATCTGCATTGCTAGATTGCCATCCAGAAAAGTTAATCAATTTGTATTCACAGCAGCAGTGTACAAGAGGGCTGGT
TTTCTGAAGATAACATTTTTTTCAGTCCTGTTCAGAGGTTTGGTCAATCTTACCTGTAGATGACTTCAGCCACCAGGCTGGATGGGAGCC
CACAGACAAAAGGACATTGGTGTATGTTATGGTGAAAACCATCAGTACCATGCCTAGCTCAAGAATGTGAAATTGAACCTGAAAAAAACT
TTGAACCTACAATTTTATGTTCTGAAAATAGTTATTCTAATGTGAGGGCATTAATAAGAATATGTACCATCAAAGCTTCAGAAGATTTTC
CGTACAAACTAAAATCACTTTTGGAGAAAGTACCTAAATAAAAAGAGAAACAAATCCAGGAGATACTGTACGGTTTGAAAGAAAGGTAAT
CAAATACTCAGAAAAAGTTTGTTGATGACTTAAAAAGGATAAATAAAAAGTAAGACTAAAGAAAATCAGTATACCCATTAATAATAAATC
TTTAGTAATCTATAAGGGGAAGAATGCTTTTCAACCTTATACACTAGAAGCATGCTCTTTAAAATTAATGCAACAGGATGACGACTTGAT

>63522_63522_3_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376752_RAB3IP_chr12_70188217_ENST00000247833_length(amino acids)=343AA_BP=84
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQEAHKM
VREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEA
DLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKS

--------------------------------------------------------------
>63522_63522_4_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376752_RAB3IP_chr12_70188217_ENST00000378815_length(transcript)=2254nt_BP=669nt
CGGAGGGAGCGCTGGGAGCGAGCAAGCGAGCGTTTGGAGCCCGGGCCAGCAGAGGGGGCGCCCGGTCGCTGCCTGTACCGCTCCCGCTGG
TCATCTCCGCCGCGCTCGGGGGCCCCGGGAGGAGCGAGACCGAGTCGGAGAGTCCGGGAGCCAAGCCGGGCGAAACCCAACTGCGGAGGA
CGCCCGCCCCACTCAGCCTCCTCCTGCGTCCGAGCCGGGGAGCATCGCCGAGCGCCCCACGGGCCGGAGAGCTGGGAGCACAGGTCCCGG
CAGCCCCAGGGATGGTCTAGGAGCCGGCGTAAGGCTCGCTGCTCTGCTCCCTGCCGGGGCTAGCCGCCTCCTGCCGATCGCCCGGGGCTG
CGAGCTGCGGCGGCCCGGGGCTGCTCGCCGGGCGGCGCAGGCCGGAGAAGTTAGTTGTGCGCGCCCTTAGTGCGCGGAACCAGCCAGCGA
GCGAGGGAGCAGCGAGGCGCCGGGACCATGGGCTGGGGGAGCCGCTGCTGCTGCCCGGGACGTTTGGACCTGCTGTGCGTGCTGGCGCTG
CTCGGGGGCTGCCTGCTCCCCGTGTGTCGGACGCGCGTCTACACCAACCACTGGGCAGTCAAAATCGCCGGGGGCTTCCCGGAGGCCAAC
CGTATCGCCAGCAAGTACGGATTCATCAACATAGGACAGGAAGCTCATAAAATGGTGAGAGAAGCAAATATCAAGCAGGCAACAGCAGAA
AAACAGCTAAAAGAAGCACAAGGAAAAATTGATGTACTTCAAGCTGAAGTAGCTGCATTGAAGACACTTGTATTGTCCAGTTCTCCAACA
TCACCTACGCAGGAGCCTTTGCCAGGTGGAAAGACACCTTTTAAAAAGGGGCATACAAGAAATAAAAGCACAAGCAGTGCTATGAGTGGC
AGTCATCAGGACCTCAGTGTGATACAGCCAATTGTAAAAGACTGCAAAGAGGTAACTCATCAAGGACTGTCCCCTCTGACTCTGTTGATA
CTTGTTAGTTCTCATCACTGAGGTGTCAGTTATCATTTTTGCCAGCAAAATTTTTAGTACAAAATAATGCAGTATTAAGATGGGGGAGGC
TTTATCTAGAGCTGGCTGCTTTCAGGGATTCTTCAGTTCCATTTTCTACCTGGCTGACCTTGGAGTACCTGCTGGAAACTTGGTAAGTTT
CTTAATCTCAGTATTTCATTAAGGGAGGAAACTGTCATGTGTTGTCTAGAGGAGAGTGGGTGGCTTTAATGATCTGGCTAGTCAAAATTT
ATTGCTAGAGTGCGCTTACAAAGTATGGATATAAGAAATATGTGAAAATAAGATGATTTTCTTAAAGATCAATACATTGCTTTTATTTAA
ATTCAGAGAGAATTTTATGTCAGCAAGGGAGTCCTAGAGTTAATTTAGATAATTAAGCAACAAAAAAATAGAAATAATGGTAGCCTTACA
ATGACATAAGGCTGGAAGACATTTTGCTAAGTGAAATTTCAAGTTATAGTAGAACAATTAGTGTCATTTTTGATCCCAAATTAGGTTTCA
CAGTTCAGCCAGTCTGTTATTCAGACACTTACAACTATGTAAGGCCACCATTATCATGTATCCATAACAATTAAAAATTTAAAAACGAAA
TAATGGGCCGGGCATGGTGGCTCATGCCTGTAATCTCAGCACTTTGGGAGGCCAAGGCCGGAGGATCACCTGAGGTTGGGAGTTCGAGAC
CAGCCTGACCAACATGGAGAAACCCTATCTGTACTAAAAATATAAAATTAGCTGGGCATGGTATCTCATGCTTATAATCCCAGCTACTCA
GGAGGCTGAGGCAGGAGAATCCCTTGAACCTGGGAGGCGGAGGTTGCGGTCAGCTGAGATTGCGCCATCACACTCCAGCCTGGGCAACAA
GAGCGAAACTCTGTCTCAAAATCATAATAATAATAATAGTCTTATTTTAAAAGATATGTTACAAAGATAACTGAAATAATATATAAATAT
TTTGAGCTGTTTAGAGTAAAAATTTTTAATCATTGTATACTGTGAGAATGCATTTCTAAGAGGATTGATCAATAATTTATGAAGCTTTCC
CATTTCTTCTTAGAAGCCATCTTTTACATTGTTAAATTCAAGTCCATCATTAATCTTGAAGAAATGTGTGTGCTTGTTAAATTTTTGTAT
GGAAGCCAGGAGTTTATTAAATGGAATAACCAATGTTAACCTGTTTTAATTGAATTGCATTTTGACGAATTATCAATAAAAATGATGCTG

>63522_63522_4_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376752_RAB3IP_chr12_70188217_ENST00000378815_length(amino acids)=198AA_BP=84
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQEAHKM
VREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEV

--------------------------------------------------------------
>63522_63522_5_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376767_RAB3IP_chr12_70178500_ENST00000247833_length(transcript)=3508nt_BP=704nt
ATTGCCACTCAGAATCCTCGCGCGCTGCTCGGAGCCGGAGGGAGCGCTGGGAGCGAGCAAGCGAGCGTTTGGAGCCCGGGCCAGCAGAGG
GGGCGCCCGGTCGCTGCCTGTACCGCTCCCGCTGGTCATCTCCGCCGCGCTCGGGGGCCCCGGGAGGAGCGAGACCGAGTCGGAGAGTCC
GGGAGCCAAGCCGGGCGAAACCCAACTGCGGAGGACGCCCGCCCCACTCAGCCTCCTCCTGCGTCCGAGCCGGGGAGCATCGCCGAGCGC
CCCACGGGCCGGAGAGCTGGGAGCACAGGTCCCGGCAGCCCCAGGGATGGTCTAGGAGCCGGCGTAAGGCTCGCTGCTCTGCTCCCTGCC
GGGGCTAGCCGCCTCCTGCCGATCGCCCGGGGCTGCGAGCTGCGGCGGCCCGGGGCTGCTCGCCGGGCGGCGCAGGCCGGAGAAGTTAGT
TGTGCGCGCCCTTAGTGCGCGGAACCAGCCAGCGAGCGAGGGAGCAGCGAGGCGCCGGGACCATGGGCTGGGGGAGCCGCTGCTGCTGCC
CGGGACGTTTGGACCTGCTGTGCGTGCTGGCGCTGCTCGGGGGCTGCCTGCTCCCCGTGTGTCGGACGCGCGTCTACACCAACCACTGGG
CAGTCAAAATCGCCGGGGGCTTCCCGGAGGCCAACCGTATCGCCAGCAAGTACGGATTCATCAACATAGGACAGGAACTGAAGTTAAAAG
ATGAAGAATGTGAGAGGCTTTCAAAAGTGCGAGATCAACTTGGACAGGAATTGGAAGAACTCACAGCTAGTCTATTTGAGGAAGCTCATA
AAATGGTGAGAGAAGCAAATATCAAGCAGGCAACAGCAGAAAAACAGCTAAAAGAAGCACAAGGAAAAATTGATGTACTTCAAGCTGAAG
TAGCTGCATTGAAGACACTTGTATTGTCCAGTTCTCCAACATCACCTACGCAGGAGCCTTTGCCAGGTGGAAAGACACCTTTTAAAAAGG
GGCATACAAGAAATAAAAGCACAAGCAGTGCTATGAGTGGCAGTCATCAGGACCTCAGTGTGATACAGCCAATTGTAAAAGACTGCAAAG
AGGCTGACTTATCCTTGTATAATGAATTCCGATTGTGGAAGGATGAGCCCACAATGGACAGGACGTGTCCTTTCTTAGACAAAATCTACC
AGGAAGATATCTTTCCATGTTTAACATTCTCAAAAAGTGAGTTGGCTTCAGCTGTTCTGGAGGCTGTGGAAAACAATACTCTAAGCATTG
AACCAGTGGGATTACAACCTATCCGGTTTGTGAAAGCTTCTGCAGTTGAATGCGGAGGACCAAAAAAATGTGCTCTCACTGGCCAGAGTA
AGTCCTGTAAACACAGAATTAAATTAGGGGACTCAAGCAACTATTATTATATTTCTCCTTTTTGCAGATACAGGATCACTTCTGTATGTA
ACTTTTTTACATACATTCGATACATTCAGCAGGGACTCGTGAAACAGCAGGATGTTGATCAGATGTTTTGGGAGGTTATGCAGTTGAGAA
AAGAGATGTCATTGGCAAAGCTGGGTTATTTCAAAGAGGAACTCTGATGCTCTGCGTGGGACCATGCCTGAACTCCCCGAATAACTGAAA
AATGGCTGAATATTTTTATGGTTACTTGATATTTATTTCCAAGGAGTGAGCCTAAGACTTTTTTCCCCTTTTGCAAATTGCTCTAAGAAG
TACCATGATTTCTTTTAAACTGATCTATGCTGTGTTTGCTTATTCTTTAGTTGAACACACTATGAAGAATTCCAGGTGTACTAGTGAATG
TAATTTATAGTTGCCAAAAAAAAAAAAAACCTGAAATAAATAAATGTTAGATTGAATGTGTGTACATTTTCTCTTCTAGCTCTGACATGG
CATTTAGGGTTAGCAGAATGTATTAAATAGTAATTTTCAAACTACACAGTAGCTTCCTTCCTTGTGAGAGGCAAGAAAGAAGTCTGAGTG
GATAGTACTCACTTTCCAAGGCCCCCACCTCTAGAATGGCTTTATTTTTATCTGTTTTCTATATTGGGTTTCAAAAAAGATTTTATTTGA
AGAAATACTTCTGCTGCTACAAAGTTTGAAAGTTACTATTTTAATTATTCTGCTCTCTGTAACTGAAAGAATCCCTTTATTTTGGTTATT
CATTAAAATATAATAGAAGGCAGTCAGATTTTATCCCAGAGATGTATTCCTGAGTGTCTTGATATAGTGTATTCATGTTTTATATGTGTT
GACCACTATATTGTCATTGGAGGGACATAGATGTAAATGAGTTTGACGTGTGTCAAAGGGGTTTAAAGGGGTGTGGATTGAATGAATGGT
ACGTGCGAAGTATATGCTGATTATAGAACCACTTGATCTCTGCATTCCAAATTGTAAAACTGACTCAACTGGAGAAATTATAACAAAGAG
GTTTGTGGTAGACATGTAATAAGTATAGAAAAGCAAAAAGAAAAGAGAAACTGCTTTAGTTTCTGTTTAGAGAAAGCTGCTGTTAATATT
TTTGGATAGTAGCCTTTCAGCTTTCAGATATTTTCTACTTACATATGCATATTTTTGAAACAAAAAGTAGGCTTTTTTTTTGCTTTTTAA
ACCTAAACATTAAATATATTTTCCCTTGGGTAAACCTACACATCCTAATCCCTGTTTATAGAATTTTAACATAATTTAATTGTGTTTGGA
GATGAGGTGGTTTTCAGTTTATTTTTCATATTATAATGCTGTGACGAGTATCCTTATCTGTACACTTCTGAACATTGTGGAGTTCTTTCA
TGTGGATGCCTGGAGATAAAATTGTGTCGAGATATATATGTATTTTTAAATGTTTGATCTGCATTGCTAGATTGCCATCCAGAAAAGTTA
ATCAATTTGTATTCACAGCAGCAGTGTACAAGAGGGCTGGTTTTCTGAAGATAACATTTTTTTCAGTCCTGTTCAGAGGTTTGGTCAATC
TTACCTGTAGATGACTTCAGCCACCAGGCTGGATGGGAGCCCACAGACAAAAGGACATTGGTGTATGTTATGGTGAAAACCATCAGTACC
ATGCCTAGCTCAAGAATGTGAAATTGAACCTGAAAAAAACTTTGAACCTACAATTTTATGTTCTGAAAATAGTTATTCTAATGTGAGGGC
ATTAATAAGAATATGTACCATCAAAGCTTCAGAAGATTTTCCGTACAAACTAAAATCACTTTTGGAGAAAGTACCTAAATAAAAAGAGAA
ACAAATCCAGGAGATACTGTACGGTTTGAAAGAAAGGTAATCAAATACTCAGAAAAAGTTTGTTGATGACTTAAAAAGGATAAATAAAAA
GTAAGACTAAAGAAAATCAGTATACCCATTAATAATAAATCTTTAGTAATCTATAAGGGGAAGAATGCTTTTCAACCTTATACACTAGAA

>63522_63522_5_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376767_RAB3IP_chr12_70178500_ENST00000247833_length(amino acids)=375AA_BP=80
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQELKLK
DEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKK
GHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEADLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSI
EPVGLQPIRFVKASAVECGGPKKCALTGQSKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLR

--------------------------------------------------------------
>63522_63522_6_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376767_RAB3IP_chr12_70178500_ENST00000378815_length(transcript)=2385nt_BP=704nt
ATTGCCACTCAGAATCCTCGCGCGCTGCTCGGAGCCGGAGGGAGCGCTGGGAGCGAGCAAGCGAGCGTTTGGAGCCCGGGCCAGCAGAGG
GGGCGCCCGGTCGCTGCCTGTACCGCTCCCGCTGGTCATCTCCGCCGCGCTCGGGGGCCCCGGGAGGAGCGAGACCGAGTCGGAGAGTCC
GGGAGCCAAGCCGGGCGAAACCCAACTGCGGAGGACGCCCGCCCCACTCAGCCTCCTCCTGCGTCCGAGCCGGGGAGCATCGCCGAGCGC
CCCACGGGCCGGAGAGCTGGGAGCACAGGTCCCGGCAGCCCCAGGGATGGTCTAGGAGCCGGCGTAAGGCTCGCTGCTCTGCTCCCTGCC
GGGGCTAGCCGCCTCCTGCCGATCGCCCGGGGCTGCGAGCTGCGGCGGCCCGGGGCTGCTCGCCGGGCGGCGCAGGCCGGAGAAGTTAGT
TGTGCGCGCCCTTAGTGCGCGGAACCAGCCAGCGAGCGAGGGAGCAGCGAGGCGCCGGGACCATGGGCTGGGGGAGCCGCTGCTGCTGCC
CGGGACGTTTGGACCTGCTGTGCGTGCTGGCGCTGCTCGGGGGCTGCCTGCTCCCCGTGTGTCGGACGCGCGTCTACACCAACCACTGGG
CAGTCAAAATCGCCGGGGGCTTCCCGGAGGCCAACCGTATCGCCAGCAAGTACGGATTCATCAACATAGGACAGGAACTGAAGTTAAAAG
ATGAAGAATGTGAGAGGCTTTCAAAAGTGCGAGATCAACTTGGACAGGAATTGGAAGAACTCACAGCTAGTCTATTTGAGGAAGCTCATA
AAATGGTGAGAGAAGCAAATATCAAGCAGGCAACAGCAGAAAAACAGCTAAAAGAAGCACAAGGAAAAATTGATGTACTTCAAGCTGAAG
TAGCTGCATTGAAGACACTTGTATTGTCCAGTTCTCCAACATCACCTACGCAGGAGCCTTTGCCAGGTGGAAAGACACCTTTTAAAAAGG
GGCATACAAGAAATAAAAGCACAAGCAGTGCTATGAGTGGCAGTCATCAGGACCTCAGTGTGATACAGCCAATTGTAAAAGACTGCAAAG
AGGTAACTCATCAAGGACTGTCCCCTCTGACTCTGTTGATACTTGTTAGTTCTCATCACTGAGGTGTCAGTTATCATTTTTGCCAGCAAA
ATTTTTAGTACAAAATAATGCAGTATTAAGATGGGGGAGGCTTTATCTAGAGCTGGCTGCTTTCAGGGATTCTTCAGTTCCATTTTCTAC
CTGGCTGACCTTGGAGTACCTGCTGGAAACTTGGTAAGTTTCTTAATCTCAGTATTTCATTAAGGGAGGAAACTGTCATGTGTTGTCTAG
AGGAGAGTGGGTGGCTTTAATGATCTGGCTAGTCAAAATTTATTGCTAGAGTGCGCTTACAAAGTATGGATATAAGAAATATGTGAAAAT
AAGATGATTTTCTTAAAGATCAATACATTGCTTTTATTTAAATTCAGAGAGAATTTTATGTCAGCAAGGGAGTCCTAGAGTTAATTTAGA
TAATTAAGCAACAAAAAAATAGAAATAATGGTAGCCTTACAATGACATAAGGCTGGAAGACATTTTGCTAAGTGAAATTTCAAGTTATAG
TAGAACAATTAGTGTCATTTTTGATCCCAAATTAGGTTTCACAGTTCAGCCAGTCTGTTATTCAGACACTTACAACTATGTAAGGCCACC
ATTATCATGTATCCATAACAATTAAAAATTTAAAAACGAAATAATGGGCCGGGCATGGTGGCTCATGCCTGTAATCTCAGCACTTTGGGA
GGCCAAGGCCGGAGGATCACCTGAGGTTGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCTATCTGTACTAAAAATATAAAATT
AGCTGGGCATGGTATCTCATGCTTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCCCTTGAACCTGGGAGGCGGAGGTTGCGG
TCAGCTGAGATTGCGCCATCACACTCCAGCCTGGGCAACAAGAGCGAAACTCTGTCTCAAAATCATAATAATAATAATAGTCTTATTTTA
AAAGATATGTTACAAAGATAACTGAAATAATATATAAATATTTTGAGCTGTTTAGAGTAAAAATTTTTAATCATTGTATACTGTGAGAAT
GCATTTCTAAGAGGATTGATCAATAATTTATGAAGCTTTCCCATTTCTTCTTAGAAGCCATCTTTTACATTGTTAAATTCAAGTCCATCA
TTAATCTTGAAGAAATGTGTGTGCTTGTTAAATTTTTGTATGGAAGCCAGGAGTTTATTAAATGGAATAACCAATGTTAACCTGTTTTAA

>63522_63522_6_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376767_RAB3IP_chr12_70178500_ENST00000378815_length(amino acids)=230AA_BP=80
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQELKLK
DEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKK

--------------------------------------------------------------
>63522_63522_7_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376767_RAB3IP_chr12_70188217_ENST00000247833_length(transcript)=3412nt_BP=704nt
ATTGCCACTCAGAATCCTCGCGCGCTGCTCGGAGCCGGAGGGAGCGCTGGGAGCGAGCAAGCGAGCGTTTGGAGCCCGGGCCAGCAGAGG
GGGCGCCCGGTCGCTGCCTGTACCGCTCCCGCTGGTCATCTCCGCCGCGCTCGGGGGCCCCGGGAGGAGCGAGACCGAGTCGGAGAGTCC
GGGAGCCAAGCCGGGCGAAACCCAACTGCGGAGGACGCCCGCCCCACTCAGCCTCCTCCTGCGTCCGAGCCGGGGAGCATCGCCGAGCGC
CCCACGGGCCGGAGAGCTGGGAGCACAGGTCCCGGCAGCCCCAGGGATGGTCTAGGAGCCGGCGTAAGGCTCGCTGCTCTGCTCCCTGCC
GGGGCTAGCCGCCTCCTGCCGATCGCCCGGGGCTGCGAGCTGCGGCGGCCCGGGGCTGCTCGCCGGGCGGCGCAGGCCGGAGAAGTTAGT
TGTGCGCGCCCTTAGTGCGCGGAACCAGCCAGCGAGCGAGGGAGCAGCGAGGCGCCGGGACCATGGGCTGGGGGAGCCGCTGCTGCTGCC
CGGGACGTTTGGACCTGCTGTGCGTGCTGGCGCTGCTCGGGGGCTGCCTGCTCCCCGTGTGTCGGACGCGCGTCTACACCAACCACTGGG
CAGTCAAAATCGCCGGGGGCTTCCCGGAGGCCAACCGTATCGCCAGCAAGTACGGATTCATCAACATAGGACAGGAAGCTCATAAAATGG
TGAGAGAAGCAAATATCAAGCAGGCAACAGCAGAAAAACAGCTAAAAGAAGCACAAGGAAAAATTGATGTACTTCAAGCTGAAGTAGCTG
CATTGAAGACACTTGTATTGTCCAGTTCTCCAACATCACCTACGCAGGAGCCTTTGCCAGGTGGAAAGACACCTTTTAAAAAGGGGCATA
CAAGAAATAAAAGCACAAGCAGTGCTATGAGTGGCAGTCATCAGGACCTCAGTGTGATACAGCCAATTGTAAAAGACTGCAAAGAGGCTG
ACTTATCCTTGTATAATGAATTCCGATTGTGGAAGGATGAGCCCACAATGGACAGGACGTGTCCTTTCTTAGACAAAATCTACCAGGAAG
ATATCTTTCCATGTTTAACATTCTCAAAAAGTGAGTTGGCTTCAGCTGTTCTGGAGGCTGTGGAAAACAATACTCTAAGCATTGAACCAG
TGGGATTACAACCTATCCGGTTTGTGAAAGCTTCTGCAGTTGAATGCGGAGGACCAAAAAAATGTGCTCTCACTGGCCAGAGTAAGTCCT
GTAAACACAGAATTAAATTAGGGGACTCAAGCAACTATTATTATATTTCTCCTTTTTGCAGATACAGGATCACTTCTGTATGTAACTTTT
TTACATACATTCGATACATTCAGCAGGGACTCGTGAAACAGCAGGATGTTGATCAGATGTTTTGGGAGGTTATGCAGTTGAGAAAAGAGA
TGTCATTGGCAAAGCTGGGTTATTTCAAAGAGGAACTCTGATGCTCTGCGTGGGACCATGCCTGAACTCCCCGAATAACTGAAAAATGGC
TGAATATTTTTATGGTTACTTGATATTTATTTCCAAGGAGTGAGCCTAAGACTTTTTTCCCCTTTTGCAAATTGCTCTAAGAAGTACCAT
GATTTCTTTTAAACTGATCTATGCTGTGTTTGCTTATTCTTTAGTTGAACACACTATGAAGAATTCCAGGTGTACTAGTGAATGTAATTT
ATAGTTGCCAAAAAAAAAAAAAACCTGAAATAAATAAATGTTAGATTGAATGTGTGTACATTTTCTCTTCTAGCTCTGACATGGCATTTA
GGGTTAGCAGAATGTATTAAATAGTAATTTTCAAACTACACAGTAGCTTCCTTCCTTGTGAGAGGCAAGAAAGAAGTCTGAGTGGATAGT
ACTCACTTTCCAAGGCCCCCACCTCTAGAATGGCTTTATTTTTATCTGTTTTCTATATTGGGTTTCAAAAAAGATTTTATTTGAAGAAAT
ACTTCTGCTGCTACAAAGTTTGAAAGTTACTATTTTAATTATTCTGCTCTCTGTAACTGAAAGAATCCCTTTATTTTGGTTATTCATTAA
AATATAATAGAAGGCAGTCAGATTTTATCCCAGAGATGTATTCCTGAGTGTCTTGATATAGTGTATTCATGTTTTATATGTGTTGACCAC
TATATTGTCATTGGAGGGACATAGATGTAAATGAGTTTGACGTGTGTCAAAGGGGTTTAAAGGGGTGTGGATTGAATGAATGGTACGTGC
GAAGTATATGCTGATTATAGAACCACTTGATCTCTGCATTCCAAATTGTAAAACTGACTCAACTGGAGAAATTATAACAAAGAGGTTTGT
GGTAGACATGTAATAAGTATAGAAAAGCAAAAAGAAAAGAGAAACTGCTTTAGTTTCTGTTTAGAGAAAGCTGCTGTTAATATTTTTGGA
TAGTAGCCTTTCAGCTTTCAGATATTTTCTACTTACATATGCATATTTTTGAAACAAAAAGTAGGCTTTTTTTTTGCTTTTTAAACCTAA
ACATTAAATATATTTTCCCTTGGGTAAACCTACACATCCTAATCCCTGTTTATAGAATTTTAACATAATTTAATTGTGTTTGGAGATGAG
GTGGTTTTCAGTTTATTTTTCATATTATAATGCTGTGACGAGTATCCTTATCTGTACACTTCTGAACATTGTGGAGTTCTTTCATGTGGA
TGCCTGGAGATAAAATTGTGTCGAGATATATATGTATTTTTAAATGTTTGATCTGCATTGCTAGATTGCCATCCAGAAAAGTTAATCAAT
TTGTATTCACAGCAGCAGTGTACAAGAGGGCTGGTTTTCTGAAGATAACATTTTTTTCAGTCCTGTTCAGAGGTTTGGTCAATCTTACCT
GTAGATGACTTCAGCCACCAGGCTGGATGGGAGCCCACAGACAAAAGGACATTGGTGTATGTTATGGTGAAAACCATCAGTACCATGCCT
AGCTCAAGAATGTGAAATTGAACCTGAAAAAAACTTTGAACCTACAATTTTATGTTCTGAAAATAGTTATTCTAATGTGAGGGCATTAAT
AAGAATATGTACCATCAAAGCTTCAGAAGATTTTCCGTACAAACTAAAATCACTTTTGGAGAAAGTACCTAAATAAAAAGAGAAACAAAT
CCAGGAGATACTGTACGGTTTGAAAGAAAGGTAATCAAATACTCAGAAAAAGTTTGTTGATGACTTAAAAAGGATAAATAAAAAGTAAGA
CTAAAGAAAATCAGTATACCCATTAATAATAAATCTTTAGTAATCTATAAGGGGAAGAATGCTTTTCAACCTTATACACTAGAAGCATGC

>63522_63522_7_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376767_RAB3IP_chr12_70188217_ENST00000247833_length(amino acids)=343AA_BP=84
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQEAHKM
VREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEA
DLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKS

--------------------------------------------------------------
>63522_63522_8_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376767_RAB3IP_chr12_70188217_ENST00000378815_length(transcript)=2289nt_BP=704nt
ATTGCCACTCAGAATCCTCGCGCGCTGCTCGGAGCCGGAGGGAGCGCTGGGAGCGAGCAAGCGAGCGTTTGGAGCCCGGGCCAGCAGAGG
GGGCGCCCGGTCGCTGCCTGTACCGCTCCCGCTGGTCATCTCCGCCGCGCTCGGGGGCCCCGGGAGGAGCGAGACCGAGTCGGAGAGTCC
GGGAGCCAAGCCGGGCGAAACCCAACTGCGGAGGACGCCCGCCCCACTCAGCCTCCTCCTGCGTCCGAGCCGGGGAGCATCGCCGAGCGC
CCCACGGGCCGGAGAGCTGGGAGCACAGGTCCCGGCAGCCCCAGGGATGGTCTAGGAGCCGGCGTAAGGCTCGCTGCTCTGCTCCCTGCC
GGGGCTAGCCGCCTCCTGCCGATCGCCCGGGGCTGCGAGCTGCGGCGGCCCGGGGCTGCTCGCCGGGCGGCGCAGGCCGGAGAAGTTAGT
TGTGCGCGCCCTTAGTGCGCGGAACCAGCCAGCGAGCGAGGGAGCAGCGAGGCGCCGGGACCATGGGCTGGGGGAGCCGCTGCTGCTGCC
CGGGACGTTTGGACCTGCTGTGCGTGCTGGCGCTGCTCGGGGGCTGCCTGCTCCCCGTGTGTCGGACGCGCGTCTACACCAACCACTGGG
CAGTCAAAATCGCCGGGGGCTTCCCGGAGGCCAACCGTATCGCCAGCAAGTACGGATTCATCAACATAGGACAGGAAGCTCATAAAATGG
TGAGAGAAGCAAATATCAAGCAGGCAACAGCAGAAAAACAGCTAAAAGAAGCACAAGGAAAAATTGATGTACTTCAAGCTGAAGTAGCTG
CATTGAAGACACTTGTATTGTCCAGTTCTCCAACATCACCTACGCAGGAGCCTTTGCCAGGTGGAAAGACACCTTTTAAAAAGGGGCATA
CAAGAAATAAAAGCACAAGCAGTGCTATGAGTGGCAGTCATCAGGACCTCAGTGTGATACAGCCAATTGTAAAAGACTGCAAAGAGGTAA
CTCATCAAGGACTGTCCCCTCTGACTCTGTTGATACTTGTTAGTTCTCATCACTGAGGTGTCAGTTATCATTTTTGCCAGCAAAATTTTT
AGTACAAAATAATGCAGTATTAAGATGGGGGAGGCTTTATCTAGAGCTGGCTGCTTTCAGGGATTCTTCAGTTCCATTTTCTACCTGGCT
GACCTTGGAGTACCTGCTGGAAACTTGGTAAGTTTCTTAATCTCAGTATTTCATTAAGGGAGGAAACTGTCATGTGTTGTCTAGAGGAGA
GTGGGTGGCTTTAATGATCTGGCTAGTCAAAATTTATTGCTAGAGTGCGCTTACAAAGTATGGATATAAGAAATATGTGAAAATAAGATG
ATTTTCTTAAAGATCAATACATTGCTTTTATTTAAATTCAGAGAGAATTTTATGTCAGCAAGGGAGTCCTAGAGTTAATTTAGATAATTA
AGCAACAAAAAAATAGAAATAATGGTAGCCTTACAATGACATAAGGCTGGAAGACATTTTGCTAAGTGAAATTTCAAGTTATAGTAGAAC
AATTAGTGTCATTTTTGATCCCAAATTAGGTTTCACAGTTCAGCCAGTCTGTTATTCAGACACTTACAACTATGTAAGGCCACCATTATC
ATGTATCCATAACAATTAAAAATTTAAAAACGAAATAATGGGCCGGGCATGGTGGCTCATGCCTGTAATCTCAGCACTTTGGGAGGCCAA
GGCCGGAGGATCACCTGAGGTTGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCTATCTGTACTAAAAATATAAAATTAGCTGG
GCATGGTATCTCATGCTTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCCCTTGAACCTGGGAGGCGGAGGTTGCGGTCAGCT
GAGATTGCGCCATCACACTCCAGCCTGGGCAACAAGAGCGAAACTCTGTCTCAAAATCATAATAATAATAATAGTCTTATTTTAAAAGAT
ATGTTACAAAGATAACTGAAATAATATATAAATATTTTGAGCTGTTTAGAGTAAAAATTTTTAATCATTGTATACTGTGAGAATGCATTT
CTAAGAGGATTGATCAATAATTTATGAAGCTTTCCCATTTCTTCTTAGAAGCCATCTTTTACATTGTTAAATTCAAGTCCATCATTAATC
TTGAAGAAATGTGTGTGCTTGTTAAATTTTTGTATGGAAGCCAGGAGTTTATTAAATGGAATAACCAATGTTAACCTGTTTTAATTGAAT

>63522_63522_8_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376767_RAB3IP_chr12_70188217_ENST00000378815_length(amino acids)=198AA_BP=84
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQEAHKM
VREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEV

--------------------------------------------------------------
>63522_63522_9_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000545128_RAB3IP_chr12_70178500_ENST00000247833_length(transcript)=3534nt_BP=730nt
ATTTATGCAGAGCAGGAGCTGCTGCCATTGCCACTCAGAATCCTCGCGCGCTGCTCGGAGCCGGAGGGAGCGCTGGGAGCGAGCAAGCGA
GCGTTTGGAGCCCGGGCCAGCAGAGGGGGCGCCCGGTCGCTGCCTGTACCGCTCCCGCTGGTCATCTCCGCCGCGCTCGGGGGCCCCGGG
AGGAGCGAGACCGAGTCGGAGAGTCCGGGAGCCAAGCCGGGCGAAACCCAACTGCGGAGGACGCCCGCCCCACTCAGCCTCCTCCTGCGT
CCGAGCCGGGGAGCATCGCCGAGCGCCCCACGGGCCGGAGAGCTGGGAGCACAGGTCCCGGCAGCCCCAGGGATGGTCTAGGAGCCGGCG
TAAGGCTCGCTGCTCTGCTCCCTGCCGGGGCTAGCCGCCTCCTGCCGATCGCCCGGGGCTGCGAGCTGCGGCGGCCCGGGGCTGCTCGCC
GGGCGGCGCAGGCCGGAGAAGTTAGTTGTGCGCGCCCTTAGTGCGCGGAACCAGCCAGCGAGCGAGGGAGCAGCGAGGCGCCGGGACCAT
GGGCTGGGGGAGCCGCTGCTGCTGCCCGGGACGTTTGGACCTGCTGTGCGTGCTGGCGCTGCTCGGGGGCTGCCTGCTCCCCGTGTGTCG
GACGCGCGTCTACACCAACCACTGGGCAGTCAAAATCGCCGGGGGCTTCCCGGAGGCCAACCGTATCGCCAGCAAGTACGGATTCATCAA
CATAGGACAGGAACTGAAGTTAAAAGATGAAGAATGTGAGAGGCTTTCAAAAGTGCGAGATCAACTTGGACAGGAATTGGAAGAACTCAC
AGCTAGTCTATTTGAGGAAGCTCATAAAATGGTGAGAGAAGCAAATATCAAGCAGGCAACAGCAGAAAAACAGCTAAAAGAAGCACAAGG
AAAAATTGATGTACTTCAAGCTGAAGTAGCTGCATTGAAGACACTTGTATTGTCCAGTTCTCCAACATCACCTACGCAGGAGCCTTTGCC
AGGTGGAAAGACACCTTTTAAAAAGGGGCATACAAGAAATAAAAGCACAAGCAGTGCTATGAGTGGCAGTCATCAGGACCTCAGTGTGAT
ACAGCCAATTGTAAAAGACTGCAAAGAGGCTGACTTATCCTTGTATAATGAATTCCGATTGTGGAAGGATGAGCCCACAATGGACAGGAC
GTGTCCTTTCTTAGACAAAATCTACCAGGAAGATATCTTTCCATGTTTAACATTCTCAAAAAGTGAGTTGGCTTCAGCTGTTCTGGAGGC
TGTGGAAAACAATACTCTAAGCATTGAACCAGTGGGATTACAACCTATCCGGTTTGTGAAAGCTTCTGCAGTTGAATGCGGAGGACCAAA
AAAATGTGCTCTCACTGGCCAGAGTAAGTCCTGTAAACACAGAATTAAATTAGGGGACTCAAGCAACTATTATTATATTTCTCCTTTTTG
CAGATACAGGATCACTTCTGTATGTAACTTTTTTACATACATTCGATACATTCAGCAGGGACTCGTGAAACAGCAGGATGTTGATCAGAT
GTTTTGGGAGGTTATGCAGTTGAGAAAAGAGATGTCATTGGCAAAGCTGGGTTATTTCAAAGAGGAACTCTGATGCTCTGCGTGGGACCA
TGCCTGAACTCCCCGAATAACTGAAAAATGGCTGAATATTTTTATGGTTACTTGATATTTATTTCCAAGGAGTGAGCCTAAGACTTTTTT
CCCCTTTTGCAAATTGCTCTAAGAAGTACCATGATTTCTTTTAAACTGATCTATGCTGTGTTTGCTTATTCTTTAGTTGAACACACTATG
AAGAATTCCAGGTGTACTAGTGAATGTAATTTATAGTTGCCAAAAAAAAAAAAAACCTGAAATAAATAAATGTTAGATTGAATGTGTGTA
CATTTTCTCTTCTAGCTCTGACATGGCATTTAGGGTTAGCAGAATGTATTAAATAGTAATTTTCAAACTACACAGTAGCTTCCTTCCTTG
TGAGAGGCAAGAAAGAAGTCTGAGTGGATAGTACTCACTTTCCAAGGCCCCCACCTCTAGAATGGCTTTATTTTTATCTGTTTTCTATAT
TGGGTTTCAAAAAAGATTTTATTTGAAGAAATACTTCTGCTGCTACAAAGTTTGAAAGTTACTATTTTAATTATTCTGCTCTCTGTAACT
GAAAGAATCCCTTTATTTTGGTTATTCATTAAAATATAATAGAAGGCAGTCAGATTTTATCCCAGAGATGTATTCCTGAGTGTCTTGATA
TAGTGTATTCATGTTTTATATGTGTTGACCACTATATTGTCATTGGAGGGACATAGATGTAAATGAGTTTGACGTGTGTCAAAGGGGTTT
AAAGGGGTGTGGATTGAATGAATGGTACGTGCGAAGTATATGCTGATTATAGAACCACTTGATCTCTGCATTCCAAATTGTAAAACTGAC
TCAACTGGAGAAATTATAACAAAGAGGTTTGTGGTAGACATGTAATAAGTATAGAAAAGCAAAAAGAAAAGAGAAACTGCTTTAGTTTCT
GTTTAGAGAAAGCTGCTGTTAATATTTTTGGATAGTAGCCTTTCAGCTTTCAGATATTTTCTACTTACATATGCATATTTTTGAAACAAA
AAGTAGGCTTTTTTTTTGCTTTTTAAACCTAAACATTAAATATATTTTCCCTTGGGTAAACCTACACATCCTAATCCCTGTTTATAGAAT
TTTAACATAATTTAATTGTGTTTGGAGATGAGGTGGTTTTCAGTTTATTTTTCATATTATAATGCTGTGACGAGTATCCTTATCTGTACA
CTTCTGAACATTGTGGAGTTCTTTCATGTGGATGCCTGGAGATAAAATTGTGTCGAGATATATATGTATTTTTAAATGTTTGATCTGCAT
TGCTAGATTGCCATCCAGAAAAGTTAATCAATTTGTATTCACAGCAGCAGTGTACAAGAGGGCTGGTTTTCTGAAGATAACATTTTTTTC
AGTCCTGTTCAGAGGTTTGGTCAATCTTACCTGTAGATGACTTCAGCCACCAGGCTGGATGGGAGCCCACAGACAAAAGGACATTGGTGT
ATGTTATGGTGAAAACCATCAGTACCATGCCTAGCTCAAGAATGTGAAATTGAACCTGAAAAAAACTTTGAACCTACAATTTTATGTTCT
GAAAATAGTTATTCTAATGTGAGGGCATTAATAAGAATATGTACCATCAAAGCTTCAGAAGATTTTCCGTACAAACTAAAATCACTTTTG
GAGAAAGTACCTAAATAAAAAGAGAAACAAATCCAGGAGATACTGTACGGTTTGAAAGAAAGGTAATCAAATACTCAGAAAAAGTTTGTT
GATGACTTAAAAAGGATAAATAAAAAGTAAGACTAAAGAAAATCAGTATACCCATTAATAATAAATCTTTAGTAATCTATAAGGGGAAGA
ATGCTTTTCAACCTTATACACTAGAAGCATGCTCTTTAAAATTAATGCAACAGGATGACGACTTGATGTAGAAACTATATGTGGAATTAT

>63522_63522_9_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000545128_RAB3IP_chr12_70178500_ENST00000247833_length(amino acids)=375AA_BP=80
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQELKLK
DEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKK
GHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEADLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSI
EPVGLQPIRFVKASAVECGGPKKCALTGQSKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLR

--------------------------------------------------------------
>63522_63522_10_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000545128_RAB3IP_chr12_70178500_ENST00000378815_length(transcript)=2411nt_BP=730nt
ATTTATGCAGAGCAGGAGCTGCTGCCATTGCCACTCAGAATCCTCGCGCGCTGCTCGGAGCCGGAGGGAGCGCTGGGAGCGAGCAAGCGA
GCGTTTGGAGCCCGGGCCAGCAGAGGGGGCGCCCGGTCGCTGCCTGTACCGCTCCCGCTGGTCATCTCCGCCGCGCTCGGGGGCCCCGGG
AGGAGCGAGACCGAGTCGGAGAGTCCGGGAGCCAAGCCGGGCGAAACCCAACTGCGGAGGACGCCCGCCCCACTCAGCCTCCTCCTGCGT
CCGAGCCGGGGAGCATCGCCGAGCGCCCCACGGGCCGGAGAGCTGGGAGCACAGGTCCCGGCAGCCCCAGGGATGGTCTAGGAGCCGGCG
TAAGGCTCGCTGCTCTGCTCCCTGCCGGGGCTAGCCGCCTCCTGCCGATCGCCCGGGGCTGCGAGCTGCGGCGGCCCGGGGCTGCTCGCC
GGGCGGCGCAGGCCGGAGAAGTTAGTTGTGCGCGCCCTTAGTGCGCGGAACCAGCCAGCGAGCGAGGGAGCAGCGAGGCGCCGGGACCAT
GGGCTGGGGGAGCCGCTGCTGCTGCCCGGGACGTTTGGACCTGCTGTGCGTGCTGGCGCTGCTCGGGGGCTGCCTGCTCCCCGTGTGTCG
GACGCGCGTCTACACCAACCACTGGGCAGTCAAAATCGCCGGGGGCTTCCCGGAGGCCAACCGTATCGCCAGCAAGTACGGATTCATCAA
CATAGGACAGGAACTGAAGTTAAAAGATGAAGAATGTGAGAGGCTTTCAAAAGTGCGAGATCAACTTGGACAGGAATTGGAAGAACTCAC
AGCTAGTCTATTTGAGGAAGCTCATAAAATGGTGAGAGAAGCAAATATCAAGCAGGCAACAGCAGAAAAACAGCTAAAAGAAGCACAAGG
AAAAATTGATGTACTTCAAGCTGAAGTAGCTGCATTGAAGACACTTGTATTGTCCAGTTCTCCAACATCACCTACGCAGGAGCCTTTGCC
AGGTGGAAAGACACCTTTTAAAAAGGGGCATACAAGAAATAAAAGCACAAGCAGTGCTATGAGTGGCAGTCATCAGGACCTCAGTGTGAT
ACAGCCAATTGTAAAAGACTGCAAAGAGGTAACTCATCAAGGACTGTCCCCTCTGACTCTGTTGATACTTGTTAGTTCTCATCACTGAGG
TGTCAGTTATCATTTTTGCCAGCAAAATTTTTAGTACAAAATAATGCAGTATTAAGATGGGGGAGGCTTTATCTAGAGCTGGCTGCTTTC
AGGGATTCTTCAGTTCCATTTTCTACCTGGCTGACCTTGGAGTACCTGCTGGAAACTTGGTAAGTTTCTTAATCTCAGTATTTCATTAAG
GGAGGAAACTGTCATGTGTTGTCTAGAGGAGAGTGGGTGGCTTTAATGATCTGGCTAGTCAAAATTTATTGCTAGAGTGCGCTTACAAAG
TATGGATATAAGAAATATGTGAAAATAAGATGATTTTCTTAAAGATCAATACATTGCTTTTATTTAAATTCAGAGAGAATTTTATGTCAG
CAAGGGAGTCCTAGAGTTAATTTAGATAATTAAGCAACAAAAAAATAGAAATAATGGTAGCCTTACAATGACATAAGGCTGGAAGACATT
TTGCTAAGTGAAATTTCAAGTTATAGTAGAACAATTAGTGTCATTTTTGATCCCAAATTAGGTTTCACAGTTCAGCCAGTCTGTTATTCA
GACACTTACAACTATGTAAGGCCACCATTATCATGTATCCATAACAATTAAAAATTTAAAAACGAAATAATGGGCCGGGCATGGTGGCTC
ATGCCTGTAATCTCAGCACTTTGGGAGGCCAAGGCCGGAGGATCACCTGAGGTTGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAAC
CCTATCTGTACTAAAAATATAAAATTAGCTGGGCATGGTATCTCATGCTTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCCC
TTGAACCTGGGAGGCGGAGGTTGCGGTCAGCTGAGATTGCGCCATCACACTCCAGCCTGGGCAACAAGAGCGAAACTCTGTCTCAAAATC
ATAATAATAATAATAGTCTTATTTTAAAAGATATGTTACAAAGATAACTGAAATAATATATAAATATTTTGAGCTGTTTAGAGTAAAAAT
TTTTAATCATTGTATACTGTGAGAATGCATTTCTAAGAGGATTGATCAATAATTTATGAAGCTTTCCCATTTCTTCTTAGAAGCCATCTT
TTACATTGTTAAATTCAAGTCCATCATTAATCTTGAAGAAATGTGTGTGCTTGTTAAATTTTTGTATGGAAGCCAGGAGTTTATTAAATG

>63522_63522_10_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000545128_RAB3IP_chr12_70178500_ENST00000378815_length(amino acids)=230AA_BP=80
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQELKLK
DEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKK

--------------------------------------------------------------
>63522_63522_11_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000545128_RAB3IP_chr12_70188217_ENST00000247833_length(transcript)=3438nt_BP=730nt
ATTTATGCAGAGCAGGAGCTGCTGCCATTGCCACTCAGAATCCTCGCGCGCTGCTCGGAGCCGGAGGGAGCGCTGGGAGCGAGCAAGCGA
GCGTTTGGAGCCCGGGCCAGCAGAGGGGGCGCCCGGTCGCTGCCTGTACCGCTCCCGCTGGTCATCTCCGCCGCGCTCGGGGGCCCCGGG
AGGAGCGAGACCGAGTCGGAGAGTCCGGGAGCCAAGCCGGGCGAAACCCAACTGCGGAGGACGCCCGCCCCACTCAGCCTCCTCCTGCGT
CCGAGCCGGGGAGCATCGCCGAGCGCCCCACGGGCCGGAGAGCTGGGAGCACAGGTCCCGGCAGCCCCAGGGATGGTCTAGGAGCCGGCG
TAAGGCTCGCTGCTCTGCTCCCTGCCGGGGCTAGCCGCCTCCTGCCGATCGCCCGGGGCTGCGAGCTGCGGCGGCCCGGGGCTGCTCGCC
GGGCGGCGCAGGCCGGAGAAGTTAGTTGTGCGCGCCCTTAGTGCGCGGAACCAGCCAGCGAGCGAGGGAGCAGCGAGGCGCCGGGACCAT
GGGCTGGGGGAGCCGCTGCTGCTGCCCGGGACGTTTGGACCTGCTGTGCGTGCTGGCGCTGCTCGGGGGCTGCCTGCTCCCCGTGTGTCG
GACGCGCGTCTACACCAACCACTGGGCAGTCAAAATCGCCGGGGGCTTCCCGGAGGCCAACCGTATCGCCAGCAAGTACGGATTCATCAA
CATAGGACAGGAAGCTCATAAAATGGTGAGAGAAGCAAATATCAAGCAGGCAACAGCAGAAAAACAGCTAAAAGAAGCACAAGGAAAAAT
TGATGTACTTCAAGCTGAAGTAGCTGCATTGAAGACACTTGTATTGTCCAGTTCTCCAACATCACCTACGCAGGAGCCTTTGCCAGGTGG
AAAGACACCTTTTAAAAAGGGGCATACAAGAAATAAAAGCACAAGCAGTGCTATGAGTGGCAGTCATCAGGACCTCAGTGTGATACAGCC
AATTGTAAAAGACTGCAAAGAGGCTGACTTATCCTTGTATAATGAATTCCGATTGTGGAAGGATGAGCCCACAATGGACAGGACGTGTCC
TTTCTTAGACAAAATCTACCAGGAAGATATCTTTCCATGTTTAACATTCTCAAAAAGTGAGTTGGCTTCAGCTGTTCTGGAGGCTGTGGA
AAACAATACTCTAAGCATTGAACCAGTGGGATTACAACCTATCCGGTTTGTGAAAGCTTCTGCAGTTGAATGCGGAGGACCAAAAAAATG
TGCTCTCACTGGCCAGAGTAAGTCCTGTAAACACAGAATTAAATTAGGGGACTCAAGCAACTATTATTATATTTCTCCTTTTTGCAGATA
CAGGATCACTTCTGTATGTAACTTTTTTACATACATTCGATACATTCAGCAGGGACTCGTGAAACAGCAGGATGTTGATCAGATGTTTTG
GGAGGTTATGCAGTTGAGAAAAGAGATGTCATTGGCAAAGCTGGGTTATTTCAAAGAGGAACTCTGATGCTCTGCGTGGGACCATGCCTG
AACTCCCCGAATAACTGAAAAATGGCTGAATATTTTTATGGTTACTTGATATTTATTTCCAAGGAGTGAGCCTAAGACTTTTTTCCCCTT
TTGCAAATTGCTCTAAGAAGTACCATGATTTCTTTTAAACTGATCTATGCTGTGTTTGCTTATTCTTTAGTTGAACACACTATGAAGAAT
TCCAGGTGTACTAGTGAATGTAATTTATAGTTGCCAAAAAAAAAAAAAACCTGAAATAAATAAATGTTAGATTGAATGTGTGTACATTTT
CTCTTCTAGCTCTGACATGGCATTTAGGGTTAGCAGAATGTATTAAATAGTAATTTTCAAACTACACAGTAGCTTCCTTCCTTGTGAGAG
GCAAGAAAGAAGTCTGAGTGGATAGTACTCACTTTCCAAGGCCCCCACCTCTAGAATGGCTTTATTTTTATCTGTTTTCTATATTGGGTT
TCAAAAAAGATTTTATTTGAAGAAATACTTCTGCTGCTACAAAGTTTGAAAGTTACTATTTTAATTATTCTGCTCTCTGTAACTGAAAGA
ATCCCTTTATTTTGGTTATTCATTAAAATATAATAGAAGGCAGTCAGATTTTATCCCAGAGATGTATTCCTGAGTGTCTTGATATAGTGT
ATTCATGTTTTATATGTGTTGACCACTATATTGTCATTGGAGGGACATAGATGTAAATGAGTTTGACGTGTGTCAAAGGGGTTTAAAGGG
GTGTGGATTGAATGAATGGTACGTGCGAAGTATATGCTGATTATAGAACCACTTGATCTCTGCATTCCAAATTGTAAAACTGACTCAACT
GGAGAAATTATAACAAAGAGGTTTGTGGTAGACATGTAATAAGTATAGAAAAGCAAAAAGAAAAGAGAAACTGCTTTAGTTTCTGTTTAG
AGAAAGCTGCTGTTAATATTTTTGGATAGTAGCCTTTCAGCTTTCAGATATTTTCTACTTACATATGCATATTTTTGAAACAAAAAGTAG
GCTTTTTTTTTGCTTTTTAAACCTAAACATTAAATATATTTTCCCTTGGGTAAACCTACACATCCTAATCCCTGTTTATAGAATTTTAAC
ATAATTTAATTGTGTTTGGAGATGAGGTGGTTTTCAGTTTATTTTTCATATTATAATGCTGTGACGAGTATCCTTATCTGTACACTTCTG
AACATTGTGGAGTTCTTTCATGTGGATGCCTGGAGATAAAATTGTGTCGAGATATATATGTATTTTTAAATGTTTGATCTGCATTGCTAG
ATTGCCATCCAGAAAAGTTAATCAATTTGTATTCACAGCAGCAGTGTACAAGAGGGCTGGTTTTCTGAAGATAACATTTTTTTCAGTCCT
GTTCAGAGGTTTGGTCAATCTTACCTGTAGATGACTTCAGCCACCAGGCTGGATGGGAGCCCACAGACAAAAGGACATTGGTGTATGTTA
TGGTGAAAACCATCAGTACCATGCCTAGCTCAAGAATGTGAAATTGAACCTGAAAAAAACTTTGAACCTACAATTTTATGTTCTGAAAAT
AGTTATTCTAATGTGAGGGCATTAATAAGAATATGTACCATCAAAGCTTCAGAAGATTTTCCGTACAAACTAAAATCACTTTTGGAGAAA
GTACCTAAATAAAAAGAGAAACAAATCCAGGAGATACTGTACGGTTTGAAAGAAAGGTAATCAAATACTCAGAAAAAGTTTGTTGATGAC
TTAAAAAGGATAAATAAAAAGTAAGACTAAAGAAAATCAGTATACCCATTAATAATAAATCTTTAGTAATCTATAAGGGGAAGAATGCTT
TTCAACCTTATACACTAGAAGCATGCTCTTTAAAATTAATGCAACAGGATGACGACTTGATGTAGAAACTATATGTGGAATTATAGATTA

>63522_63522_11_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000545128_RAB3IP_chr12_70188217_ENST00000247833_length(amino acids)=343AA_BP=84
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQEAHKM
VREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEA
DLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKS

--------------------------------------------------------------
>63522_63522_12_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000545128_RAB3IP_chr12_70188217_ENST00000378815_length(transcript)=2315nt_BP=730nt
ATTTATGCAGAGCAGGAGCTGCTGCCATTGCCACTCAGAATCCTCGCGCGCTGCTCGGAGCCGGAGGGAGCGCTGGGAGCGAGCAAGCGA
GCGTTTGGAGCCCGGGCCAGCAGAGGGGGCGCCCGGTCGCTGCCTGTACCGCTCCCGCTGGTCATCTCCGCCGCGCTCGGGGGCCCCGGG
AGGAGCGAGACCGAGTCGGAGAGTCCGGGAGCCAAGCCGGGCGAAACCCAACTGCGGAGGACGCCCGCCCCACTCAGCCTCCTCCTGCGT
CCGAGCCGGGGAGCATCGCCGAGCGCCCCACGGGCCGGAGAGCTGGGAGCACAGGTCCCGGCAGCCCCAGGGATGGTCTAGGAGCCGGCG
TAAGGCTCGCTGCTCTGCTCCCTGCCGGGGCTAGCCGCCTCCTGCCGATCGCCCGGGGCTGCGAGCTGCGGCGGCCCGGGGCTGCTCGCC
GGGCGGCGCAGGCCGGAGAAGTTAGTTGTGCGCGCCCTTAGTGCGCGGAACCAGCCAGCGAGCGAGGGAGCAGCGAGGCGCCGGGACCAT
GGGCTGGGGGAGCCGCTGCTGCTGCCCGGGACGTTTGGACCTGCTGTGCGTGCTGGCGCTGCTCGGGGGCTGCCTGCTCCCCGTGTGTCG
GACGCGCGTCTACACCAACCACTGGGCAGTCAAAATCGCCGGGGGCTTCCCGGAGGCCAACCGTATCGCCAGCAAGTACGGATTCATCAA
CATAGGACAGGAAGCTCATAAAATGGTGAGAGAAGCAAATATCAAGCAGGCAACAGCAGAAAAACAGCTAAAAGAAGCACAAGGAAAAAT
TGATGTACTTCAAGCTGAAGTAGCTGCATTGAAGACACTTGTATTGTCCAGTTCTCCAACATCACCTACGCAGGAGCCTTTGCCAGGTGG
AAAGACACCTTTTAAAAAGGGGCATACAAGAAATAAAAGCACAAGCAGTGCTATGAGTGGCAGTCATCAGGACCTCAGTGTGATACAGCC
AATTGTAAAAGACTGCAAAGAGGTAACTCATCAAGGACTGTCCCCTCTGACTCTGTTGATACTTGTTAGTTCTCATCACTGAGGTGTCAG
TTATCATTTTTGCCAGCAAAATTTTTAGTACAAAATAATGCAGTATTAAGATGGGGGAGGCTTTATCTAGAGCTGGCTGCTTTCAGGGAT
TCTTCAGTTCCATTTTCTACCTGGCTGACCTTGGAGTACCTGCTGGAAACTTGGTAAGTTTCTTAATCTCAGTATTTCATTAAGGGAGGA
AACTGTCATGTGTTGTCTAGAGGAGAGTGGGTGGCTTTAATGATCTGGCTAGTCAAAATTTATTGCTAGAGTGCGCTTACAAAGTATGGA
TATAAGAAATATGTGAAAATAAGATGATTTTCTTAAAGATCAATACATTGCTTTTATTTAAATTCAGAGAGAATTTTATGTCAGCAAGGG
AGTCCTAGAGTTAATTTAGATAATTAAGCAACAAAAAAATAGAAATAATGGTAGCCTTACAATGACATAAGGCTGGAAGACATTTTGCTA
AGTGAAATTTCAAGTTATAGTAGAACAATTAGTGTCATTTTTGATCCCAAATTAGGTTTCACAGTTCAGCCAGTCTGTTATTCAGACACT
TACAACTATGTAAGGCCACCATTATCATGTATCCATAACAATTAAAAATTTAAAAACGAAATAATGGGCCGGGCATGGTGGCTCATGCCT
GTAATCTCAGCACTTTGGGAGGCCAAGGCCGGAGGATCACCTGAGGTTGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCTATC
TGTACTAAAAATATAAAATTAGCTGGGCATGGTATCTCATGCTTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCCCTTGAAC
CTGGGAGGCGGAGGTTGCGGTCAGCTGAGATTGCGCCATCACACTCCAGCCTGGGCAACAAGAGCGAAACTCTGTCTCAAAATCATAATA
ATAATAATAGTCTTATTTTAAAAGATATGTTACAAAGATAACTGAAATAATATATAAATATTTTGAGCTGTTTAGAGTAAAAATTTTTAA
TCATTGTATACTGTGAGAATGCATTTCTAAGAGGATTGATCAATAATTTATGAAGCTTTCCCATTTCTTCTTAGAAGCCATCTTTTACAT
TGTTAAATTCAAGTCCATCATTAATCTTGAAGAAATGTGTGTGCTTGTTAAATTTTTGTATGGAAGCCAGGAGTTTATTAAATGGAATAA

>63522_63522_12_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000545128_RAB3IP_chr12_70188217_ENST00000378815_length(amino acids)=198AA_BP=84
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQEAHKM
VREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PCSK5-RAB3IP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PCSK5-RAB3IP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PCSK5-RAB3IP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource