FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PCTP-BRIP1 (FusionGDB2 ID:63541)

Fusion Gene Summary for PCTP-BRIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PCTP-BRIP1
Fusion gene ID: 63541
HgeneTgene
Gene symbol

PCTP

BRIP1

Gene ID

58488

83990

Gene namephosphatidylcholine transfer proteinBRCA1 interacting protein C-terminal helicase 1
SynonymsPC-TP|STARD2BACH1|FANCJ|OF
Cytomap

17q22

17q23.2

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylcholine transfer proteinSTART domain-containing protein 2StAR-related lipid transfer (START) domain containing 2stAR-related lipid transfer protein 2Fanconi anemia group J proteinATP-dependent RNA helicase BRIP1BRCA1-associated C-terminal helicase 1BRCA1-binding helicase-like protein BACH1BRCA1/BRCA2-associated helicase 1
Modification date2020031320200315
UniProtAcc.

Q9BX63

Ensembl transtripts involved in fusion geneENST00000268896, ENST00000573500, 
ENST00000576183, ENST00000325214, 
ENST00000576221, 		ENST00000583837, 
ENST00000259008, ENST00000577598, 
Fusion gene scores* DoF score6 X 3 X 5=9012 X 15 X 7=1260
# samples 713
** MAII scorelog2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1260*10)=-3.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCTP [Title/Abstract] AND BRIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPCTP(53828605)-BRIP1(59861785), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePCTP

GO:0015914

phospholipid transport

12055623

TgeneBRIP1

GO:0006357

regulation of transcription by RNA polymerase II

14504288


check buttonFusion gene breakpoints across PCTP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-IE-A3OV-01APCTPchr17

53828605

+BRIP1chr17

59861785

-


Top

Fusion Gene ORF analysis for PCTP-BRIP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000268896ENST00000583837PCTPchr17

53828605

+BRIP1chr17

59861785

-
5CDS-intronENST00000573500ENST00000583837PCTPchr17

53828605

+BRIP1chr17

59861785

-
5CDS-intronENST00000576183ENST00000583837PCTPchr17

53828605

+BRIP1chr17

59861785

-
In-frameENST00000268896ENST00000259008PCTPchr17

53828605

+BRIP1chr17

59861785

-
In-frameENST00000268896ENST00000577598PCTPchr17

53828605

+BRIP1chr17

59861785

-
In-frameENST00000573500ENST00000259008PCTPchr17

53828605

+BRIP1chr17

59861785

-
In-frameENST00000573500ENST00000577598PCTPchr17

53828605

+BRIP1chr17

59861785

-
In-frameENST00000576183ENST00000259008PCTPchr17

53828605

+BRIP1chr17

59861785

-
In-frameENST00000576183ENST00000577598PCTPchr17

53828605

+BRIP1chr17

59861785

-
intron-3CDSENST00000325214ENST00000259008PCTPchr17

53828605

+BRIP1chr17

59861785

-
intron-3CDSENST00000325214ENST00000577598PCTPchr17

53828605

+BRIP1chr17

59861785

-
intron-3CDSENST00000576221ENST00000259008PCTPchr17

53828605

+BRIP1chr17

59861785

-
intron-3CDSENST00000576221ENST00000577598PCTPchr17

53828605

+BRIP1chr17

59861785

-
intron-intronENST00000325214ENST00000583837PCTPchr17

53828605

+BRIP1chr17

59861785

-
intron-intronENST00000576221ENST00000583837PCTPchr17

53828605

+BRIP1chr17

59861785

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000573500PCTPchr1753828605+ENST00000259008BRIP1chr1759861785-4458151102427805
ENST00000573500PCTPchr1753828605+ENST00000577598BRIP1chr1759861785-2647151101662550
ENST00000268896PCTPchr1753828605+ENST00000259008BRIP1chr1759861785-4573266892542817
ENST00000268896PCTPchr1753828605+ENST00000577598BRIP1chr1759861785-2762266891777562
ENST00000576183PCTPchr1753828605+ENST00000259008BRIP1chr1759861785-449118472460817
ENST00000576183PCTPchr1753828605+ENST00000577598BRIP1chr1759861785-268018471695562

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000573500ENST00000259008PCTPchr1753828605+BRIP1chr1759861785-0.0004583020.99954176
ENST00000573500ENST00000577598PCTPchr1753828605+BRIP1chr1759861785-0.0005651950.99943477
ENST00000268896ENST00000259008PCTPchr1753828605+BRIP1chr1759861785-0.0004621820.9995378
ENST00000268896ENST00000577598PCTPchr1753828605+BRIP1chr1759861785-0.0005896870.9994103
ENST00000576183ENST00000259008PCTPchr1753828605+BRIP1chr1759861785-0.0004669560.99953306
ENST00000576183ENST00000577598PCTPchr1753828605+BRIP1chr1759861785-0.000596270.9994037

Top

Fusion Genomic Features for PCTP-BRIP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PCTP-BRIP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:53828605/chr17:59861785)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BRIP1

Q9BX63

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCTPchr17:53828605chr17:59861785ENST00000268896+161_21247215.0DomainSTART
HgenePCTPchr17:53828605chr17:59861785ENST00000325214+161_2120143.0DomainSTART
TgeneBRIP1chr17:53828605chr17:59861785ENST0000025900892011_4424911250.0DomainHelicase ATP-binding
TgeneBRIP1chr17:53828605chr17:59861785ENST00000259008920158_1754911250.0MotifNuclear localization signal
TgeneBRIP1chr17:53828605chr17:59861785ENST00000259008920393_3964911250.0MotifNote=DEAH box
TgeneBRIP1chr17:53828605chr17:59861785ENST00000259008920185_1924911250.0Nucleotide bindingATP


Top

Fusion Gene Sequence for PCTP-BRIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63541_63541_1_PCTP-BRIP1_PCTP_chr17_53828605_ENST00000268896_BRIP1_chr17_59861785_ENST00000259008_length(transcript)=4573nt_BP=266nt
AGTTTCCTGCCAATGACGCTGGGGCAGCCGGGGCAGCCGGGGCAGCCCGGTCACCCCGCCCCCAGGCCCACACTAAGGGTGTCCGCGGCC
TGCCCTCCAGGCGGAGGAGCCCGGACTGCGGAAGGATGGAGCTGGCCGCCGGAAGCTTCTCGGAGGAGCAGTTCTGGGAGGCCTGCGCCG
AGCTCCAGCAGCCCGCTCTGGCCGGGGCCGACTGGCAGCTCCTAGTGGAGACCTCGGGCATCAGCATCTACCGGCTGCTGGACAAGGGAC
ATTTTTCTGCTGTTCTTCAAAAAGAGGAAAAAATCTCACCAATTTATGGTAAAGAGGAGGCAAGAGAAGTACCTGTTATTAGTGCATCAA
CTCAAATAATGCTTAAAGGACTTTTTATGGTACTTGACTATCTTTTTAGGCAAAATAGCAGATTTGCAGATGATTATAAAATTGCGATTC
AACAGACTTACTCCTGGACAAATCAGATTGATATTTCAGACAAAAATGGGTTGTTGGTTCTACCAAAAAATAAGAAACGTTCACGACAGA
AAACTGCAGTTCATGTGCTAAACTTTTGGTGCTTAAATCCAGCTGTGGCCTTTTCAGATATTAATGGCAAAGTTCAGACCATTGTTTTGA
CATCTGGTACATTATCACCAATGAAATCCTTTTCGTCAGAACTTGGTGTTACATTTACTATCCAGCTGGAGGCTAATCATATCATTAAAA
ATTCACAGGTTTGGGTTGGTACCATTGGGTCAGGCCCCAAGGGTCGGAATCTCTGTGCTACCTTCCAGAATACTGAAACATTTGAGTTCC
AAGATGAAGTGGGAGCACTTTTGTTATCTGTGTGCCAGACTGTGAGCCAAGGAATTTTGTGTTTCTTGCCATCTTACAAGTTATTAGAAA
AATTAAAAGAACGTTGGCTCTCTACTGGTTTATGGCATAATCTGGAGTTGGTGAAGACAGTCATTGTAGAACCACAGGGAGGAGAAAAAA
CAAATTTTGATGAATTACTGCAGGTGTACTATGACGCAATCAAATACAAAGGAGAGAAAGATGGAGCTCTCCTGGTAGCAGTTTGTCGTG
GTAAAGTGAGTGAGGGTCTGGATTTCTCAGATGACAATGCCCGTGCTGTCATAACAATAGGAATTCCTTTTCCAAATGTGAAAGATCTAC
AGGTTGAACTAAAACGACAATACAATGACCACCATTCAAAATTGAGAGGTCTTCTACCTGGCCGTCAGTGGTATGAAATTCAAGCATACA
GGGCCTTAAACCAGGCCCTTGGTAGATGTATTAGACACAGAAATGATTGGGGAGCTCTTATTCTAGTGGATGATCGCTTTAGGAATAACC
CAAGTCGCTATATATCTGGACTTTCTAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTGGAATCCTTGGCTG
AATTTTCCAAAAAGCATCAAAAAGTTCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACACTTGAAGTGACCT
CTTTAAAGTACAGTACCTCACCTTATTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAAGCAAAGATATGTG
TCCAGGAACTACAGTGTCCTAAAATTATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAAAATGATCCAGTAT
TCCTGGAAGAAGCAGGGAAAGCAGAAAAAATTGTGATTTCCAGATCCACAAGCCCAACTTTCAACAAACAAACAAAGAGAGTTAGCTGGT
CAAGCTTTAATTCTTTGGGACAGTATTTTACTGGTAAAATACCGAAGGCAACACCTGAGCTCGGGTCATCAGAGAATAGTGCCTCTAGTC
CTCCCCGTTTCAAAACAGAGAAGATGGAAAGTAAAACTGTTTTGCCCTTCACTGATAAATGTGAATCCTCAAATCTGACAGTAAACACAT
CGTTTGGATCATGCCCTCAATCAGAAACCATTATTTCATCATTAAAGATTGATGCCACCCTTACTAGAAAAAATCATTCTGAACATCCGC
TCTGTTCTGAAGAAGCCCTGGATCCAGACATTGAATTGTCTCTAGTAAGTGAAGAAGATAAACAGTCCACTTCAAATAGAGATTTTGAAA
CAGAAGCAGAAGATGAATCTATCTATTTTACACCTGAACTTTATGATCCTGAAGATACAGATGAAGAAAAAAATGACCTAGCTGAAACTG
ATAGAGGAAATAGATTGGCTAACAATTCAGATTGCATTTTAGCTAAAGACCTTTTTGAAATTAGAACTATAAAAGAAGTAGATTCAGCCA
GAGAAGTGAAAGCTGAGGATTGCATAGATACAAAGTTGAATGGAATTCTGCATATTGAAGAAAGTAAAATTGATGACATTGATGGTAATG
TAAAAACAACTTGGATAAATGAACTGGAACTGGGAAAAACTCATGAAATAGAAATAAAGAACTTTAAACCATCTCCTTCCAAAAATAAAG
GCATGTTTCCTGGTTTTAAGTAATAATACTTAACTCTCAAGCTAAGTAAAAATATGTCATCATGCTTATGTTAAACTCTGTTGTAAGTAA
TAATTTGTAAATTGAATAAGTGGCATACTTTTTAAAAAACTATTTTATGTTCAGAAATGTAAATGTTATTATTCTTGAGTTTTTGGGTTT
TTTTTTTTGAGACAGAGTCTTGGTCTGTTGCCCAGGCTGGAATGCAGTGGTGTGCTCTGGGCTCACTGCAACCTTCACCTCCAGGTTCAA
GTGATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTACAGGTGTGCACCACCATGCCCAGCTAGTTTTTGTATTTTTAGTAGAGATGG
GGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCGTGATCTGCCCTTCTCTGCCTCCCTAAGTTGCTGGGATTACAGGTGT
GAGCCACAGTGCCTGGCCCATTCTTGAGTTTTGATAAAGTAATTCATACAAAGTACTGTCCTCAAATAAGTCTTCCTTAGCTAAATGCAA
TTTAAAATTATTCAAAGATCCTAGGGCACTTCTAGTTTCACGTAAATATTCATATTAGGTGGTTCTCTTCATCCATTTGTTTTCACACTG
ATACATAAAAATTAACAGCAGTCTAATCTAGTGACACCTCAGTCATATTTCGCTATAGATTTTACCTCAAATCAGTCCAAGACTTTTTCA
GAGATCACCATTTGTCTTGAAAGGTTTATTTCGTTATTAAACTGCCTACTTATAAGTAATTAAGAGAAATTAAGAAAGTAGTATGCATTT
TTAATTGAAATTGTTTTACATTCTTTGTATAATAAACCTAAAACCAAACATGTCATAAACAAATTGACGTAAAGATATAAAATGCCAAAT
GAAGTATTCCAAATTTTCTATTCTAATTATTTAGCTTCACCATCATTGTGGAAAAAAATACTAGATCCTGCTTAGTATTATATATTTTTC
CTAGTGGATCAGTGAGTAATAAGTACCAAACACTAGACTAGAAGGTAATTTCTACATTGTTTAGAAAGGGTGAAACAATTTATCCCCTCT
GGTATTGTTCTAGCATAAGCTTTAGTTATACAATGATTAAGATAGAAAACTTCATATATAAATTTGATAAGCAAACCCACATTTATAGCT
GCAGCTAAAATATGTTTCCTTAGGGCACAGTAATCCTTTCTGTGAATTTTGACCTTGTTTGTGTTTTTGTGAATGAAGCTATATGTCTAA
TCAAAAATGATTATAAAAGAGGCTCATCTCTGACATCATTCCAAAAATACATTCATTGATCTCTTTTTAAGAAACATCTGTTATTCACTG
GGCATTGGGACTTTTTGTGAGTAATTTGAATTGAAATTTTATGAGCTATCCAAGAATTCTGTATGGTCTATTATTTTCAAGTCAAAATTT
CCAGTAAGGATTTACTTTACATTTCATTTGGATAAATGAATCATTATATAGGTATGTCTTTGCTTCCATTTTGAGACATTTAGATTTTTA
CAGCCTGTTTCTATAGCATTTGATGTTACAACTCTAAGCGTAGTTCAAAGACATTTAAATTGACAAGTTACCAGTTAAAGAATTTAGAAT
ATATTAGATCCCATCTAGTATTATATATTTTTTCTAGTTGATCATTGAGCAGTAAATACCAAATACTCGATTAGAAGGTAATTTTTACAT
TGTTTTGAAAGGGTGAAACAATTTATCTCCTCTGGTATTATTCTTAAACCACAGATAGGGATAGTAGGGTAGTGAAACGAATAAATACCT
GGTAGAAGACAAGAGACTTGGGCTCTACACCTGGCTCTGCCACTGATTTGCTAAGTCATATTGGCAATCACCACACCCTTCAGGGAATTA
GTTTCATCTGTAAAATGCAGCGGTTAGTACTATAAAATCATACAAATTTCTTTGTGCTTTGAGAATCTATAAAGGAATGTCTGTTGATAT

>63541_63541_1_PCTP-BRIP1_PCTP_chr17_53828605_ENST00000268896_BRIP1_chr17_59861785_ENST00000259008_length(amino acids)=817AA_BP=59
MPSRRRSPDCGRMELAAGSFSEEQFWEACAELQQPALAGADWQLLVETSGISIYRLLDKGHFSAVLQKEEKISPIYGKEEAREVPVISAS
TQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVL
TSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLE
KLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDL
QVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLA
EFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPV
FLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNT
SFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAET
DRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILHIEESKIDDIDGNVKTTWINELELGKTHEIEIKNFKPSPSKNK

--------------------------------------------------------------
>63541_63541_2_PCTP-BRIP1_PCTP_chr17_53828605_ENST00000268896_BRIP1_chr17_59861785_ENST00000577598_length(transcript)=2762nt_BP=266nt
AGTTTCCTGCCAATGACGCTGGGGCAGCCGGGGCAGCCGGGGCAGCCCGGTCACCCCGCCCCCAGGCCCACACTAAGGGTGTCCGCGGCC
TGCCCTCCAGGCGGAGGAGCCCGGACTGCGGAAGGATGGAGCTGGCCGCCGGAAGCTTCTCGGAGGAGCAGTTCTGGGAGGCCTGCGCCG
AGCTCCAGCAGCCCGCTCTGGCCGGGGCCGACTGGCAGCTCCTAGTGGAGACCTCGGGCATCAGCATCTACCGGCTGCTGGACAAGGGAC
ATTTTTCTGCTGTTCTTCAAAAAGAGGAAAAAATCTCACCAATTTATGGTAAAGAGGAGGCAAGAGAAGTACCTGTTATTAGTGCATCAA
CTCAAATAATGCTTAAAGGACTTTTTATGGTACTTGACTATCTTTTTAGGCAAAATAGCAGATTTGCAGATGATTATAAAATTGCGATTC
AACAGACTTACTCCTGGACAAATCAGATTGATATTTCAGACAAAAATGGGTTGTTGGTTCTACCAAAAAATAAGAAACGTTCACGACAGA
AAACTGCAGTTCATGTGCTAAACTTTTGGTGCTTAAATCCAGCTGTGGCCTTTTCAGATATTAATGGCAAAGTTCAGACCATTGTTTTGA
CATCTGGTACATTATCACCAATGAAATCCTTTTCGTCAGAACTTGGTGTTACATTTACTATCCAGCTGGAGGCTAATCATATCATTAAAA
ATTCACAGGTTTGGGTTGGTACCATTGGGTCAGGCCCCAAGGGTCGGAATCTCTGTGCTACCTTCCAGAATACTGAAACATTTGAGTTCC
AAGATGAAGTGGGAGCACTTTTGTTATCTGTGTGCCAGACTGTGAGCCAAGGAATTTTGTGTTTCTTGCCATCTTACAAGTTATTAGAAA
AATTAAAAGAACGTTGGCTCTCTACTGGTTTATGGCATAATCTGGAGTTGGTGAAGACAGTCATTGTAGAACCACAGGGAGGAGAAAAAA
CAAATTTTGATGAATTACTGCAGGTGTACTATGACGCAATCAAATACAAAGGAGAGAAAGATGGAGCTCTCCTGGTAGCAGTTTGTCGTG
GTAAAGTGAGTGAGGGTCTGGATTTCTCAGATGACAATGCCCGTGCTGTCATAACAATAGGAATTCCTTTTCCAAATGTGAAAGATCTAC
AGGTTGAACTAAAACGACAATACAATGACCACCATTCAAAATTGAGAGGTCTTCTACCTGGCCGTCAGTGGTATGAAATTCAAGCATACA
GGGCCTTAAACCAGGCCCTTGGTAGATGTATTAGACACAGAAATGATTGGGGAGCTCTTATTCTAGTGGATGATCGCTTTAGGAATAACC
CAAGTCGCTATATATCTGGACTTTCTAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTGGAATCCTTGGCTG
AATTTTCCAAAAAGCATCAAAAAGTTCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACACTTGAAGTGACCT
CTTTAAAGTACAGTACCTCACCTTATTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAAGCAAAGATATGTG
TCCAGGAACTACAGTGTCCTAAAATTATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAAAGTATGAAAAGTT
CTTCCCATTTACCTTTGATAGAGAAGTCTTTCATTATATTTAGTGAAATGATATTTATTTGGGTATAGATTAATTCCTTAAATATGGTGG
TTTGTAATATAAGGTGTTATCATAAAATAGTGAAACAGTATGGTGTACTGTAATGGGAACAAACTTTTGTCAGGAGACCAGAGCATATTT
TCTGGTTTTCCACTAACTGGCTTTGCCACTTACTAGCTTTGTGATCATGAGCAAGTCATTTGTCCTTTTTGAGTCGTAATAGGAAAAAAA
AAATGCCTGCCTAGCTATCCCTTCAGGTTGGGTTGTAAAGGTCAAAATTATAAATATCACAGCATTGTAAAGTACCATGTAAGTGGTAGA
TGTTATTCTAAAGGCTATATAAAAATTTGGCCTAATTTTTATGTAGATACTTCTATATGAACTACTTTTCCTATATAGATAGTTCTTATG
AACTTATTTTTAGGAGGTGAGAGACATTTATTTTAAGTGATGAAAAATAATATTTTAAAATATTTTGAAATAATCATCTGTATCAGATTG
GCAAACTGTGGCCCATGGGCCAAATTTGGCCTGCTGCCTGTTTTTGTAAATAAAGTTTAATGAAATGTAGTCATGCCCATTTATTTACAT
TTTAGAAACAACAGCAGAGTTGAGTATTTGTGTGTATTGCACTAGAACAGCATAATTGAGTAGTCGCAACAGATACATTATGCTCCACAA
AGCCTAAATATTACTATCTGGCCTATGACAGAAAAGGTTTGCCAAACTCTGGTCTATTCCATTGGATATAATTTCAGTTGTTTTAATTCA
TATATCCAAGGCGGGTGGATCATCCGAGGTCAGGAGTCCGAGACCAGCCTGACCAGTGTGGTGAAACACCGTCTCTACTAAAAAAATACA
AAAATTAGCTGGGTGTGGAGGCAGCTGTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACTGGGAGGTGGAGGT

>63541_63541_2_PCTP-BRIP1_PCTP_chr17_53828605_ENST00000268896_BRIP1_chr17_59861785_ENST00000577598_length(amino acids)=562AA_BP=59
MPSRRRSPDCGRMELAAGSFSEEQFWEACAELQQPALAGADWQLLVETSGISIYRLLDKGHFSAVLQKEEKISPIYGKEEAREVPVISAS
TQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVL
TSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLE
KLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDL
QVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLA
EFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKSMKS

--------------------------------------------------------------
>63541_63541_3_PCTP-BRIP1_PCTP_chr17_53828605_ENST00000573500_BRIP1_chr17_59861785_ENST00000259008_length(transcript)=4458nt_BP=151nt
CTGCGGAAGGATGGAGCTGGCCGCCGGAAGCTTCTCGGAGGAGCAGTTCTGGGAGGCCTGCGCCGAGCTCCAGCAGCCCGCTCTGGCCGG
GGCCGACTGGCAGCTCCTAGTGGAGACCTCGGGCATCAGCATCTACCGGCTGCTGGACAAGGGACATTTTTCTGCTGTTCTTCAAAAAGA
GGAAAAAATCTCACCAATTTATGGTAAAGAGGAGGCAAGAGAAGTACCTGTTATTAGTGCATCAACTCAAATAATGCTTAAAGGACTTTT
TATGGTACTTGACTATCTTTTTAGGCAAAATAGCAGATTTGCAGATGATTATAAAATTGCGATTCAACAGACTTACTCCTGGACAAATCA
GATTGATATTTCAGACAAAAATGGGTTGTTGGTTCTACCAAAAAATAAGAAACGTTCACGACAGAAAACTGCAGTTCATGTGCTAAACTT
TTGGTGCTTAAATCCAGCTGTGGCCTTTTCAGATATTAATGGCAAAGTTCAGACCATTGTTTTGACATCTGGTACATTATCACCAATGAA
ATCCTTTTCGTCAGAACTTGGTGTTACATTTACTATCCAGCTGGAGGCTAATCATATCATTAAAAATTCACAGGTTTGGGTTGGTACCAT
TGGGTCAGGCCCCAAGGGTCGGAATCTCTGTGCTACCTTCCAGAATACTGAAACATTTGAGTTCCAAGATGAAGTGGGAGCACTTTTGTT
ATCTGTGTGCCAGACTGTGAGCCAAGGAATTTTGTGTTTCTTGCCATCTTACAAGTTATTAGAAAAATTAAAAGAACGTTGGCTCTCTAC
TGGTTTATGGCATAATCTGGAGTTGGTGAAGACAGTCATTGTAGAACCACAGGGAGGAGAAAAAACAAATTTTGATGAATTACTGCAGGT
GTACTATGACGCAATCAAATACAAAGGAGAGAAAGATGGAGCTCTCCTGGTAGCAGTTTGTCGTGGTAAAGTGAGTGAGGGTCTGGATTT
CTCAGATGACAATGCCCGTGCTGTCATAACAATAGGAATTCCTTTTCCAAATGTGAAAGATCTACAGGTTGAACTAAAACGACAATACAA
TGACCACCATTCAAAATTGAGAGGTCTTCTACCTGGCCGTCAGTGGTATGAAATTCAAGCATACAGGGCCTTAAACCAGGCCCTTGGTAG
ATGTATTAGACACAGAAATGATTGGGGAGCTCTTATTCTAGTGGATGATCGCTTTAGGAATAACCCAAGTCGCTATATATCTGGACTTTC
TAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTGGAATCCTTGGCTGAATTTTCCAAAAAGCATCAAAAAGT
TCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACACTTGAAGTGACCTCTTTAAAGTACAGTACCTCACCTTA
TTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAAGCAAAGATATGTGTCCAGGAACTACAGTGTCCTAAAAT
TATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAAAATGATCCAGTATTCCTGGAAGAAGCAGGGAAAGCAGA
AAAAATTGTGATTTCCAGATCCACAAGCCCAACTTTCAACAAACAAACAAAGAGAGTTAGCTGGTCAAGCTTTAATTCTTTGGGACAGTA
TTTTACTGGTAAAATACCGAAGGCAACACCTGAGCTCGGGTCATCAGAGAATAGTGCCTCTAGTCCTCCCCGTTTCAAAACAGAGAAGAT
GGAAAGTAAAACTGTTTTGCCCTTCACTGATAAATGTGAATCCTCAAATCTGACAGTAAACACATCGTTTGGATCATGCCCTCAATCAGA
AACCATTATTTCATCATTAAAGATTGATGCCACCCTTACTAGAAAAAATCATTCTGAACATCCGCTCTGTTCTGAAGAAGCCCTGGATCC
AGACATTGAATTGTCTCTAGTAAGTGAAGAAGATAAACAGTCCACTTCAAATAGAGATTTTGAAACAGAAGCAGAAGATGAATCTATCTA
TTTTACACCTGAACTTTATGATCCTGAAGATACAGATGAAGAAAAAAATGACCTAGCTGAAACTGATAGAGGAAATAGATTGGCTAACAA
TTCAGATTGCATTTTAGCTAAAGACCTTTTTGAAATTAGAACTATAAAAGAAGTAGATTCAGCCAGAGAAGTGAAAGCTGAGGATTGCAT
AGATACAAAGTTGAATGGAATTCTGCATATTGAAGAAAGTAAAATTGATGACATTGATGGTAATGTAAAAACAACTTGGATAAATGAACT
GGAACTGGGAAAAACTCATGAAATAGAAATAAAGAACTTTAAACCATCTCCTTCCAAAAATAAAGGCATGTTTCCTGGTTTTAAGTAATA
ATACTTAACTCTCAAGCTAAGTAAAAATATGTCATCATGCTTATGTTAAACTCTGTTGTAAGTAATAATTTGTAAATTGAATAAGTGGCA
TACTTTTTAAAAAACTATTTTATGTTCAGAAATGTAAATGTTATTATTCTTGAGTTTTTGGGTTTTTTTTTTTGAGACAGAGTCTTGGTC
TGTTGCCCAGGCTGGAATGCAGTGGTGTGCTCTGGGCTCACTGCAACCTTCACCTCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTTCTG
AGTAGCTGGGACTACAGGTGTGCACCACCATGCCCAGCTAGTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGG
TCTCGAACTCCTGGCCTCGTGATCTGCCCTTCTCTGCCTCCCTAAGTTGCTGGGATTACAGGTGTGAGCCACAGTGCCTGGCCCATTCTT
GAGTTTTGATAAAGTAATTCATACAAAGTACTGTCCTCAAATAAGTCTTCCTTAGCTAAATGCAATTTAAAATTATTCAAAGATCCTAGG
GCACTTCTAGTTTCACGTAAATATTCATATTAGGTGGTTCTCTTCATCCATTTGTTTTCACACTGATACATAAAAATTAACAGCAGTCTA
ATCTAGTGACACCTCAGTCATATTTCGCTATAGATTTTACCTCAAATCAGTCCAAGACTTTTTCAGAGATCACCATTTGTCTTGAAAGGT
TTATTTCGTTATTAAACTGCCTACTTATAAGTAATTAAGAGAAATTAAGAAAGTAGTATGCATTTTTAATTGAAATTGTTTTACATTCTT
TGTATAATAAACCTAAAACCAAACATGTCATAAACAAATTGACGTAAAGATATAAAATGCCAAATGAAGTATTCCAAATTTTCTATTCTA
ATTATTTAGCTTCACCATCATTGTGGAAAAAAATACTAGATCCTGCTTAGTATTATATATTTTTCCTAGTGGATCAGTGAGTAATAAGTA
CCAAACACTAGACTAGAAGGTAATTTCTACATTGTTTAGAAAGGGTGAAACAATTTATCCCCTCTGGTATTGTTCTAGCATAAGCTTTAG
TTATACAATGATTAAGATAGAAAACTTCATATATAAATTTGATAAGCAAACCCACATTTATAGCTGCAGCTAAAATATGTTTCCTTAGGG
CACAGTAATCCTTTCTGTGAATTTTGACCTTGTTTGTGTTTTTGTGAATGAAGCTATATGTCTAATCAAAAATGATTATAAAAGAGGCTC
ATCTCTGACATCATTCCAAAAATACATTCATTGATCTCTTTTTAAGAAACATCTGTTATTCACTGGGCATTGGGACTTTTTGTGAGTAAT
TTGAATTGAAATTTTATGAGCTATCCAAGAATTCTGTATGGTCTATTATTTTCAAGTCAAAATTTCCAGTAAGGATTTACTTTACATTTC
ATTTGGATAAATGAATCATTATATAGGTATGTCTTTGCTTCCATTTTGAGACATTTAGATTTTTACAGCCTGTTTCTATAGCATTTGATG
TTACAACTCTAAGCGTAGTTCAAAGACATTTAAATTGACAAGTTACCAGTTAAAGAATTTAGAATATATTAGATCCCATCTAGTATTATA
TATTTTTTCTAGTTGATCATTGAGCAGTAAATACCAAATACTCGATTAGAAGGTAATTTTTACATTGTTTTGAAAGGGTGAAACAATTTA
TCTCCTCTGGTATTATTCTTAAACCACAGATAGGGATAGTAGGGTAGTGAAACGAATAAATACCTGGTAGAAGACAAGAGACTTGGGCTC
TACACCTGGCTCTGCCACTGATTTGCTAAGTCATATTGGCAATCACCACACCCTTCAGGGAATTAGTTTCATCTGTAAAATGCAGCGGTT
AGTACTATAAAATCATACAAATTTCTTTGTGCTTTGAGAATCTATAAAGGAATGTCTGTTGATATTCTGAGTCGATTTTCATTTGCTTTT

>63541_63541_3_PCTP-BRIP1_PCTP_chr17_53828605_ENST00000573500_BRIP1_chr17_59861785_ENST00000259008_length(amino acids)=805AA_BP=47
MELAAGSFSEEQFWEACAELQQPALAGADWQLLVETSGISIYRLLDKGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVL
DYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFS
SELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLW
HNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHH
SKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNV
SIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIV
ISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETII
SSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDC

--------------------------------------------------------------
>63541_63541_4_PCTP-BRIP1_PCTP_chr17_53828605_ENST00000573500_BRIP1_chr17_59861785_ENST00000577598_length(transcript)=2647nt_BP=151nt
CTGCGGAAGGATGGAGCTGGCCGCCGGAAGCTTCTCGGAGGAGCAGTTCTGGGAGGCCTGCGCCGAGCTCCAGCAGCCCGCTCTGGCCGG
GGCCGACTGGCAGCTCCTAGTGGAGACCTCGGGCATCAGCATCTACCGGCTGCTGGACAAGGGACATTTTTCTGCTGTTCTTCAAAAAGA
GGAAAAAATCTCACCAATTTATGGTAAAGAGGAGGCAAGAGAAGTACCTGTTATTAGTGCATCAACTCAAATAATGCTTAAAGGACTTTT
TATGGTACTTGACTATCTTTTTAGGCAAAATAGCAGATTTGCAGATGATTATAAAATTGCGATTCAACAGACTTACTCCTGGACAAATCA
GATTGATATTTCAGACAAAAATGGGTTGTTGGTTCTACCAAAAAATAAGAAACGTTCACGACAGAAAACTGCAGTTCATGTGCTAAACTT
TTGGTGCTTAAATCCAGCTGTGGCCTTTTCAGATATTAATGGCAAAGTTCAGACCATTGTTTTGACATCTGGTACATTATCACCAATGAA
ATCCTTTTCGTCAGAACTTGGTGTTACATTTACTATCCAGCTGGAGGCTAATCATATCATTAAAAATTCACAGGTTTGGGTTGGTACCAT
TGGGTCAGGCCCCAAGGGTCGGAATCTCTGTGCTACCTTCCAGAATACTGAAACATTTGAGTTCCAAGATGAAGTGGGAGCACTTTTGTT
ATCTGTGTGCCAGACTGTGAGCCAAGGAATTTTGTGTTTCTTGCCATCTTACAAGTTATTAGAAAAATTAAAAGAACGTTGGCTCTCTAC
TGGTTTATGGCATAATCTGGAGTTGGTGAAGACAGTCATTGTAGAACCACAGGGAGGAGAAAAAACAAATTTTGATGAATTACTGCAGGT
GTACTATGACGCAATCAAATACAAAGGAGAGAAAGATGGAGCTCTCCTGGTAGCAGTTTGTCGTGGTAAAGTGAGTGAGGGTCTGGATTT
CTCAGATGACAATGCCCGTGCTGTCATAACAATAGGAATTCCTTTTCCAAATGTGAAAGATCTACAGGTTGAACTAAAACGACAATACAA
TGACCACCATTCAAAATTGAGAGGTCTTCTACCTGGCCGTCAGTGGTATGAAATTCAAGCATACAGGGCCTTAAACCAGGCCCTTGGTAG
ATGTATTAGACACAGAAATGATTGGGGAGCTCTTATTCTAGTGGATGATCGCTTTAGGAATAACCCAAGTCGCTATATATCTGGACTTTC
TAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTGGAATCCTTGGCTGAATTTTCCAAAAAGCATCAAAAAGT
TCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACACTTGAAGTGACCTCTTTAAAGTACAGTACCTCACCTTA
TTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAAGCAAAGATATGTGTCCAGGAACTACAGTGTCCTAAAAT
TATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAAAGTATGAAAAGTTCTTCCCATTTACCTTTGATAGAGAA
GTCTTTCATTATATTTAGTGAAATGATATTTATTTGGGTATAGATTAATTCCTTAAATATGGTGGTTTGTAATATAAGGTGTTATCATAA
AATAGTGAAACAGTATGGTGTACTGTAATGGGAACAAACTTTTGTCAGGAGACCAGAGCATATTTTCTGGTTTTCCACTAACTGGCTTTG
CCACTTACTAGCTTTGTGATCATGAGCAAGTCATTTGTCCTTTTTGAGTCGTAATAGGAAAAAAAAAATGCCTGCCTAGCTATCCCTTCA
GGTTGGGTTGTAAAGGTCAAAATTATAAATATCACAGCATTGTAAAGTACCATGTAAGTGGTAGATGTTATTCTAAAGGCTATATAAAAA
TTTGGCCTAATTTTTATGTAGATACTTCTATATGAACTACTTTTCCTATATAGATAGTTCTTATGAACTTATTTTTAGGAGGTGAGAGAC
ATTTATTTTAAGTGATGAAAAATAATATTTTAAAATATTTTGAAATAATCATCTGTATCAGATTGGCAAACTGTGGCCCATGGGCCAAAT
TTGGCCTGCTGCCTGTTTTTGTAAATAAAGTTTAATGAAATGTAGTCATGCCCATTTATTTACATTTTAGAAACAACAGCAGAGTTGAGT
ATTTGTGTGTATTGCACTAGAACAGCATAATTGAGTAGTCGCAACAGATACATTATGCTCCACAAAGCCTAAATATTACTATCTGGCCTA
TGACAGAAAAGGTTTGCCAAACTCTGGTCTATTCCATTGGATATAATTTCAGTTGTTTTAATTCATATATCCAAGGCGGGTGGATCATCC
GAGGTCAGGAGTCCGAGACCAGCCTGACCAGTGTGGTGAAACACCGTCTCTACTAAAAAAATACAAAAATTAGCTGGGTGTGGAGGCAGC
TGTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACTGGGAGGTGGAGGTTGCAGTGAGCCAGGATTGCGCCATT

>63541_63541_4_PCTP-BRIP1_PCTP_chr17_53828605_ENST00000573500_BRIP1_chr17_59861785_ENST00000577598_length(amino acids)=550AA_BP=47
MELAAGSFSEEQFWEACAELQQPALAGADWQLLVETSGISIYRLLDKGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVL
DYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFS
SELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLW
HNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHH
SKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNV
SIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKSMKSSSHLPLIEKSFI

--------------------------------------------------------------
>63541_63541_5_PCTP-BRIP1_PCTP_chr17_53828605_ENST00000576183_BRIP1_chr17_59861785_ENST00000259008_length(transcript)=4491nt_BP=184nt
CCGCGGCCTGCCCTCCAGGCGGAGGAGCCCGGACTGCGGAAGGATGGAGCTGGCCGCCGGAAGCTTCTCGGAGGAGCAGTTCTGGGAGGC
CTGCGCCGAGCTCCAGCAGCCCGCTCTGGCCGGGGCCGACTGGCAGCTCCTAGTGGAGACCTCGGGCATCAGCATCTACCGGCTGCTGGA
CAAGGGACATTTTTCTGCTGTTCTTCAAAAAGAGGAAAAAATCTCACCAATTTATGGTAAAGAGGAGGCAAGAGAAGTACCTGTTATTAG
TGCATCAACTCAAATAATGCTTAAAGGACTTTTTATGGTACTTGACTATCTTTTTAGGCAAAATAGCAGATTTGCAGATGATTATAAAAT
TGCGATTCAACAGACTTACTCCTGGACAAATCAGATTGATATTTCAGACAAAAATGGGTTGTTGGTTCTACCAAAAAATAAGAAACGTTC
ACGACAGAAAACTGCAGTTCATGTGCTAAACTTTTGGTGCTTAAATCCAGCTGTGGCCTTTTCAGATATTAATGGCAAAGTTCAGACCAT
TGTTTTGACATCTGGTACATTATCACCAATGAAATCCTTTTCGTCAGAACTTGGTGTTACATTTACTATCCAGCTGGAGGCTAATCATAT
CATTAAAAATTCACAGGTTTGGGTTGGTACCATTGGGTCAGGCCCCAAGGGTCGGAATCTCTGTGCTACCTTCCAGAATACTGAAACATT
TGAGTTCCAAGATGAAGTGGGAGCACTTTTGTTATCTGTGTGCCAGACTGTGAGCCAAGGAATTTTGTGTTTCTTGCCATCTTACAAGTT
ATTAGAAAAATTAAAAGAACGTTGGCTCTCTACTGGTTTATGGCATAATCTGGAGTTGGTGAAGACAGTCATTGTAGAACCACAGGGAGG
AGAAAAAACAAATTTTGATGAATTACTGCAGGTGTACTATGACGCAATCAAATACAAAGGAGAGAAAGATGGAGCTCTCCTGGTAGCAGT
TTGTCGTGGTAAAGTGAGTGAGGGTCTGGATTTCTCAGATGACAATGCCCGTGCTGTCATAACAATAGGAATTCCTTTTCCAAATGTGAA
AGATCTACAGGTTGAACTAAAACGACAATACAATGACCACCATTCAAAATTGAGAGGTCTTCTACCTGGCCGTCAGTGGTATGAAATTCA
AGCATACAGGGCCTTAAACCAGGCCCTTGGTAGATGTATTAGACACAGAAATGATTGGGGAGCTCTTATTCTAGTGGATGATCGCTTTAG
GAATAACCCAAGTCGCTATATATCTGGACTTTCTAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTGGAATC
CTTGGCTGAATTTTCCAAAAAGCATCAAAAAGTTCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACACTTGA
AGTGACCTCTTTAAAGTACAGTACCTCACCTTATTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAAGCAAA
GATATGTGTCCAGGAACTACAGTGTCCTAAAATTATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAAAATGA
TCCAGTATTCCTGGAAGAAGCAGGGAAAGCAGAAAAAATTGTGATTTCCAGATCCACAAGCCCAACTTTCAACAAACAAACAAAGAGAGT
TAGCTGGTCAAGCTTTAATTCTTTGGGACAGTATTTTACTGGTAAAATACCGAAGGCAACACCTGAGCTCGGGTCATCAGAGAATAGTGC
CTCTAGTCCTCCCCGTTTCAAAACAGAGAAGATGGAAAGTAAAACTGTTTTGCCCTTCACTGATAAATGTGAATCCTCAAATCTGACAGT
AAACACATCGTTTGGATCATGCCCTCAATCAGAAACCATTATTTCATCATTAAAGATTGATGCCACCCTTACTAGAAAAAATCATTCTGA
ACATCCGCTCTGTTCTGAAGAAGCCCTGGATCCAGACATTGAATTGTCTCTAGTAAGTGAAGAAGATAAACAGTCCACTTCAAATAGAGA
TTTTGAAACAGAAGCAGAAGATGAATCTATCTATTTTACACCTGAACTTTATGATCCTGAAGATACAGATGAAGAAAAAAATGACCTAGC
TGAAACTGATAGAGGAAATAGATTGGCTAACAATTCAGATTGCATTTTAGCTAAAGACCTTTTTGAAATTAGAACTATAAAAGAAGTAGA
TTCAGCCAGAGAAGTGAAAGCTGAGGATTGCATAGATACAAAGTTGAATGGAATTCTGCATATTGAAGAAAGTAAAATTGATGACATTGA
TGGTAATGTAAAAACAACTTGGATAAATGAACTGGAACTGGGAAAAACTCATGAAATAGAAATAAAGAACTTTAAACCATCTCCTTCCAA
AAATAAAGGCATGTTTCCTGGTTTTAAGTAATAATACTTAACTCTCAAGCTAAGTAAAAATATGTCATCATGCTTATGTTAAACTCTGTT
GTAAGTAATAATTTGTAAATTGAATAAGTGGCATACTTTTTAAAAAACTATTTTATGTTCAGAAATGTAAATGTTATTATTCTTGAGTTT
TTGGGTTTTTTTTTTTGAGACAGAGTCTTGGTCTGTTGCCCAGGCTGGAATGCAGTGGTGTGCTCTGGGCTCACTGCAACCTTCACCTCC
AGGTTCAAGTGATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTACAGGTGTGCACCACCATGCCCAGCTAGTTTTTGTATTTTTAGT
AGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCGTGATCTGCCCTTCTCTGCCTCCCTAAGTTGCTGGGATT
ACAGGTGTGAGCCACAGTGCCTGGCCCATTCTTGAGTTTTGATAAAGTAATTCATACAAAGTACTGTCCTCAAATAAGTCTTCCTTAGCT
AAATGCAATTTAAAATTATTCAAAGATCCTAGGGCACTTCTAGTTTCACGTAAATATTCATATTAGGTGGTTCTCTTCATCCATTTGTTT
TCACACTGATACATAAAAATTAACAGCAGTCTAATCTAGTGACACCTCAGTCATATTTCGCTATAGATTTTACCTCAAATCAGTCCAAGA
CTTTTTCAGAGATCACCATTTGTCTTGAAAGGTTTATTTCGTTATTAAACTGCCTACTTATAAGTAATTAAGAGAAATTAAGAAAGTAGT
ATGCATTTTTAATTGAAATTGTTTTACATTCTTTGTATAATAAACCTAAAACCAAACATGTCATAAACAAATTGACGTAAAGATATAAAA
TGCCAAATGAAGTATTCCAAATTTTCTATTCTAATTATTTAGCTTCACCATCATTGTGGAAAAAAATACTAGATCCTGCTTAGTATTATA
TATTTTTCCTAGTGGATCAGTGAGTAATAAGTACCAAACACTAGACTAGAAGGTAATTTCTACATTGTTTAGAAAGGGTGAAACAATTTA
TCCCCTCTGGTATTGTTCTAGCATAAGCTTTAGTTATACAATGATTAAGATAGAAAACTTCATATATAAATTTGATAAGCAAACCCACAT
TTATAGCTGCAGCTAAAATATGTTTCCTTAGGGCACAGTAATCCTTTCTGTGAATTTTGACCTTGTTTGTGTTTTTGTGAATGAAGCTAT
ATGTCTAATCAAAAATGATTATAAAAGAGGCTCATCTCTGACATCATTCCAAAAATACATTCATTGATCTCTTTTTAAGAAACATCTGTT
ATTCACTGGGCATTGGGACTTTTTGTGAGTAATTTGAATTGAAATTTTATGAGCTATCCAAGAATTCTGTATGGTCTATTATTTTCAAGT
CAAAATTTCCAGTAAGGATTTACTTTACATTTCATTTGGATAAATGAATCATTATATAGGTATGTCTTTGCTTCCATTTTGAGACATTTA
GATTTTTACAGCCTGTTTCTATAGCATTTGATGTTACAACTCTAAGCGTAGTTCAAAGACATTTAAATTGACAAGTTACCAGTTAAAGAA
TTTAGAATATATTAGATCCCATCTAGTATTATATATTTTTTCTAGTTGATCATTGAGCAGTAAATACCAAATACTCGATTAGAAGGTAAT
TTTTACATTGTTTTGAAAGGGTGAAACAATTTATCTCCTCTGGTATTATTCTTAAACCACAGATAGGGATAGTAGGGTAGTGAAACGAAT
AAATACCTGGTAGAAGACAAGAGACTTGGGCTCTACACCTGGCTCTGCCACTGATTTGCTAAGTCATATTGGCAATCACCACACCCTTCA
GGGAATTAGTTTCATCTGTAAAATGCAGCGGTTAGTACTATAAAATCATACAAATTTCTTTGTGCTTTGAGAATCTATAAAGGAATGTCT

>63541_63541_5_PCTP-BRIP1_PCTP_chr17_53828605_ENST00000576183_BRIP1_chr17_59861785_ENST00000259008_length(amino acids)=817AA_BP=59
MPSRRRSPDCGRMELAAGSFSEEQFWEACAELQQPALAGADWQLLVETSGISIYRLLDKGHFSAVLQKEEKISPIYGKEEAREVPVISAS
TQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVL
TSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLE
KLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDL
QVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLA
EFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPV
FLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNT
SFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAET
DRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILHIEESKIDDIDGNVKTTWINELELGKTHEIEIKNFKPSPSKNK

--------------------------------------------------------------
>63541_63541_6_PCTP-BRIP1_PCTP_chr17_53828605_ENST00000576183_BRIP1_chr17_59861785_ENST00000577598_length(transcript)=2680nt_BP=184nt
CCGCGGCCTGCCCTCCAGGCGGAGGAGCCCGGACTGCGGAAGGATGGAGCTGGCCGCCGGAAGCTTCTCGGAGGAGCAGTTCTGGGAGGC
CTGCGCCGAGCTCCAGCAGCCCGCTCTGGCCGGGGCCGACTGGCAGCTCCTAGTGGAGACCTCGGGCATCAGCATCTACCGGCTGCTGGA
CAAGGGACATTTTTCTGCTGTTCTTCAAAAAGAGGAAAAAATCTCACCAATTTATGGTAAAGAGGAGGCAAGAGAAGTACCTGTTATTAG
TGCATCAACTCAAATAATGCTTAAAGGACTTTTTATGGTACTTGACTATCTTTTTAGGCAAAATAGCAGATTTGCAGATGATTATAAAAT
TGCGATTCAACAGACTTACTCCTGGACAAATCAGATTGATATTTCAGACAAAAATGGGTTGTTGGTTCTACCAAAAAATAAGAAACGTTC
ACGACAGAAAACTGCAGTTCATGTGCTAAACTTTTGGTGCTTAAATCCAGCTGTGGCCTTTTCAGATATTAATGGCAAAGTTCAGACCAT
TGTTTTGACATCTGGTACATTATCACCAATGAAATCCTTTTCGTCAGAACTTGGTGTTACATTTACTATCCAGCTGGAGGCTAATCATAT
CATTAAAAATTCACAGGTTTGGGTTGGTACCATTGGGTCAGGCCCCAAGGGTCGGAATCTCTGTGCTACCTTCCAGAATACTGAAACATT
TGAGTTCCAAGATGAAGTGGGAGCACTTTTGTTATCTGTGTGCCAGACTGTGAGCCAAGGAATTTTGTGTTTCTTGCCATCTTACAAGTT
ATTAGAAAAATTAAAAGAACGTTGGCTCTCTACTGGTTTATGGCATAATCTGGAGTTGGTGAAGACAGTCATTGTAGAACCACAGGGAGG
AGAAAAAACAAATTTTGATGAATTACTGCAGGTGTACTATGACGCAATCAAATACAAAGGAGAGAAAGATGGAGCTCTCCTGGTAGCAGT
TTGTCGTGGTAAAGTGAGTGAGGGTCTGGATTTCTCAGATGACAATGCCCGTGCTGTCATAACAATAGGAATTCCTTTTCCAAATGTGAA
AGATCTACAGGTTGAACTAAAACGACAATACAATGACCACCATTCAAAATTGAGAGGTCTTCTACCTGGCCGTCAGTGGTATGAAATTCA
AGCATACAGGGCCTTAAACCAGGCCCTTGGTAGATGTATTAGACACAGAAATGATTGGGGAGCTCTTATTCTAGTGGATGATCGCTTTAG
GAATAACCCAAGTCGCTATATATCTGGACTTTCTAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTGGAATC
CTTGGCTGAATTTTCCAAAAAGCATCAAAAAGTTCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACACTTGA
AGTGACCTCTTTAAAGTACAGTACCTCACCTTATTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAAGCAAA
GATATGTGTCCAGGAACTACAGTGTCCTAAAATTATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAAAGTAT
GAAAAGTTCTTCCCATTTACCTTTGATAGAGAAGTCTTTCATTATATTTAGTGAAATGATATTTATTTGGGTATAGATTAATTCCTTAAA
TATGGTGGTTTGTAATATAAGGTGTTATCATAAAATAGTGAAACAGTATGGTGTACTGTAATGGGAACAAACTTTTGTCAGGAGACCAGA
GCATATTTTCTGGTTTTCCACTAACTGGCTTTGCCACTTACTAGCTTTGTGATCATGAGCAAGTCATTTGTCCTTTTTGAGTCGTAATAG
GAAAAAAAAAATGCCTGCCTAGCTATCCCTTCAGGTTGGGTTGTAAAGGTCAAAATTATAAATATCACAGCATTGTAAAGTACCATGTAA
GTGGTAGATGTTATTCTAAAGGCTATATAAAAATTTGGCCTAATTTTTATGTAGATACTTCTATATGAACTACTTTTCCTATATAGATAG
TTCTTATGAACTTATTTTTAGGAGGTGAGAGACATTTATTTTAAGTGATGAAAAATAATATTTTAAAATATTTTGAAATAATCATCTGTA
TCAGATTGGCAAACTGTGGCCCATGGGCCAAATTTGGCCTGCTGCCTGTTTTTGTAAATAAAGTTTAATGAAATGTAGTCATGCCCATTT
ATTTACATTTTAGAAACAACAGCAGAGTTGAGTATTTGTGTGTATTGCACTAGAACAGCATAATTGAGTAGTCGCAACAGATACATTATG
CTCCACAAAGCCTAAATATTACTATCTGGCCTATGACAGAAAAGGTTTGCCAAACTCTGGTCTATTCCATTGGATATAATTTCAGTTGTT
TTAATTCATATATCCAAGGCGGGTGGATCATCCGAGGTCAGGAGTCCGAGACCAGCCTGACCAGTGTGGTGAAACACCGTCTCTACTAAA
AAAATACAAAAATTAGCTGGGTGTGGAGGCAGCTGTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACTGGGAG

>63541_63541_6_PCTP-BRIP1_PCTP_chr17_53828605_ENST00000576183_BRIP1_chr17_59861785_ENST00000577598_length(amino acids)=562AA_BP=59
MPSRRRSPDCGRMELAAGSFSEEQFWEACAELQQPALAGADWQLLVETSGISIYRLLDKGHFSAVLQKEEKISPIYGKEEAREVPVISAS
TQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVL
TSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLE
KLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDL
QVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLA
EFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKSMKS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PCTP-BRIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneBRIP1chr17:53828605chr17:59861785ENST00000259008920888_1063491.01250.0BRCA1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PCTP-BRIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PCTP-BRIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource