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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDCD10-ARHGAP15 (FusionGDB2 ID:63577)

Fusion Gene Summary for PDCD10-ARHGAP15

check button Fusion gene summary
Fusion gene informationFusion gene name: PDCD10-ARHGAP15
Fusion gene ID: 63577
HgeneTgene
Gene symbol

PDCD10

ARHGAP15

Gene ID

11235

55843

Gene nameprogrammed cell death 10Rho GTPase activating protein 15
SynonymsCCM3|TFAR15BM046
Cytomap

3q26.1

2q22.2-q22.3

Type of geneprotein-codingprotein-coding
Descriptionprogrammed cell death protein 10TF-1 cell apoptosis-related protein 15apoptosis-related protein 15cerebral cavernous malformations 3 proteinrho GTPase-activating protein 15rho-type GTPase-activating protein 15
Modification date2020031320200313
UniProtAcc.

Q53QZ3

Ensembl transtripts involved in fusion geneENST00000392750, ENST00000461494, 
ENST00000470131, ENST00000471885, 
ENST00000473645, ENST00000487947, 
ENST00000497056, ENST00000487678, 
ENST00000492396, 		ENST00000473426, 
ENST00000295095, ENST00000409869, 
Fusion gene scores* DoF score4 X 4 X 3=4813 X 10 X 9=1170
# samples 515
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/1170*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDCD10 [Title/Abstract] AND ARHGAP15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDCD10(167437849)-ARHGAP15(143986148), # samples:1
Anticipated loss of major functional domain due to fusion event.PDCD10-ARHGAP15 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PDCD10-ARHGAP15 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDCD10

GO:0008284

positive regulation of cell proliferation

17360971|23541896

HgenePDCD10

GO:0030335

positive regulation of cell migration

23541896

HgenePDCD10

GO:0032874

positive regulation of stress-activated MAPK cascade

22652780

HgenePDCD10

GO:0042542

response to hydrogen peroxide

22291017

HgenePDCD10

GO:0043066

negative regulation of apoptotic process

17360971

HgenePDCD10

GO:0043406

positive regulation of MAP kinase activity

17360971

TgeneARHGAP15

GO:0008360

regulation of cell shape

12650940


check buttonFusion gene breakpoints across PDCD10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGAP15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAV760860PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+


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Fusion Gene ORF analysis for PDCD10-ARHGAP15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000392750ENST00000473426PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
5CDS-intronENST00000461494ENST00000473426PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
5CDS-intronENST00000470131ENST00000473426PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
5CDS-intronENST00000471885ENST00000473426PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
5CDS-intronENST00000473645ENST00000473426PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
5CDS-intronENST00000487947ENST00000473426PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
5CDS-intronENST00000497056ENST00000473426PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
Frame-shiftENST00000470131ENST00000295095PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
Frame-shiftENST00000470131ENST00000409869PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
Frame-shiftENST00000471885ENST00000295095PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
Frame-shiftENST00000471885ENST00000409869PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
Frame-shiftENST00000473645ENST00000295095PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
Frame-shiftENST00000473645ENST00000409869PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
Frame-shiftENST00000497056ENST00000295095PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
Frame-shiftENST00000497056ENST00000409869PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
In-frameENST00000392750ENST00000295095PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
In-frameENST00000392750ENST00000409869PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
In-frameENST00000461494ENST00000295095PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
In-frameENST00000461494ENST00000409869PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
In-frameENST00000487947ENST00000295095PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
In-frameENST00000487947ENST00000409869PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
intron-3CDSENST00000487678ENST00000295095PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
intron-3CDSENST00000487678ENST00000409869PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
intron-3CDSENST00000492396ENST00000295095PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
intron-3CDSENST00000492396ENST00000409869PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
intron-intronENST00000487678ENST00000473426PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+
intron-intronENST00000492396ENST00000473426PDCD10chr3

167437849

-ARHGAP15chr2

143986148

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392750PDCD10chr3167437849-ENST00000409869ARHGAP15chr2143986148+300951460784077
ENST00000392750PDCD10chr3167437849-ENST00000295095ARHGAP15chr2143986148+18265144461645399
ENST00000461494PDCD10chr3167437849-ENST00000409869ARHGAP15chr2143986148+282032541865177
ENST00000461494PDCD10chr3167437849-ENST00000295095ARHGAP15chr2143986148+16373252571456399
ENST00000487947PDCD10chr3167437849-ENST00000409869ARHGAP15chr2143986148+273123632956277
ENST00000487947PDCD10chr3167437849-ENST00000295095ARHGAP15chr2143986148+15482361681367399

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392750ENST00000409869PDCD10chr3167437849-ARHGAP15chr2143986148+0.573737260.42626277
ENST00000392750ENST00000295095PDCD10chr3167437849-ARHGAP15chr2143986148+0.0012437210.9987563
ENST00000461494ENST00000409869PDCD10chr3167437849-ARHGAP15chr2143986148+0.68967070.31032935
ENST00000461494ENST00000295095PDCD10chr3167437849-ARHGAP15chr2143986148+0.0014278390.9985721
ENST00000487947ENST00000409869PDCD10chr3167437849-ARHGAP15chr2143986148+0.9438340.05616599
ENST00000487947ENST00000295095PDCD10chr3167437849-ARHGAP15chr2143986148+0.0019194610.9980805

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Fusion Genomic Features for PDCD10-ARHGAP15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PDCD10chr3167437849-ARHGAP15chr2143986149+1.97E-070.99999976
PDCD10chr3167437849-ARHGAP15chr2143986149+1.97E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PDCD10-ARHGAP15


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:167437849/chr2:143986148)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARHGAP15

Q53QZ3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGAP15chr3:167437849chr2:143986148ENST00000295095314281_47098476.0DomainRho-GAP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGAP15chr3:167437849chr2:143986148ENST0000029509531479_18998476.0DomainPH


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Fusion Gene Sequence for PDCD10-ARHGAP15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63577_63577_1_PDCD10-ARHGAP15_PDCD10_chr3_167437849_ENST00000392750_ARHGAP15_chr2_143986148_ENST00000295095_length(transcript)=1826nt_BP=514nt
AAGTCAGTGCCTCAGTTGCTGGTAAGGTGTAGCTGTTCTGTCCCAGTCCCCGTAGCTCTGCACCGAGCAGAAGAGGTCTAGGGTCACGCA
GGGGCCATGGCTGAGGCACTTGGGCTTGGTTCTGGCAGGCGGAGCGGACGGGGCTGAGAGCGGGGCCCTACGGGCGGAAGAGGAGCACTG
GAAGAAGGAAGAGACAAATGTTGGGGTCTACGGATTCAGTTCCAGTTTAATGATGTGGCCCTCTAAGGAGATAATTTTGCCTTAAACAGA
AAGACTTGACCCTCTTAGGTGTCATACCTAAGATCAGTGTGTTTTTTGTGTCCAATTCTTTTATCACCAAAAAAGAGAAGAAATATTGCA
GTGAATGAAGATTCCTCTGCATTTTAGCACTGCTTTTTCAACTGTAGTTGGCTTTTGAATGAGGATGACAATGGAAGAGATGAAGAATGA
AGCTGAGACCACATCCATGGTTTCTATGCCCCTCTATGCAGTCATGTATCCTGTGTTTAATGAGGAAAAACTGGTCTACTTCCTGGATTG
TTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTCTGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGG
ATTTGTGTGGAGCACACATTGAATGGGCCAAGGAAAAATCGAGCAGAAAGAATGTCTTTCAGATCACAACAGTATCAGGAAATGAGTTCC
TTCTACAGTCAGATATTGACTTCATCATATTGGATTGGTTCCACGCTATCAAAAATGCAATTGACAGATTGCCAAAGGATTCAAGTTGTC
CATCAAGAAACCTGGAATTATTCAAAATCCAAAGATCCTCTAGCACTGAATTGCTAAGTCACTACGACAGTGATATAAAAGAACAGAAAC
CAGAGCACAGAAAATCTTTAATGTTCAGACTGCATCACAGTGCTTCCGATACAAGCGACAAAAATCGAGTTAAAAGCAGATTAAAGAAGT
TTATTACCCGAAGACCTTCCCTGAAAACTCTGCAAGAAAAAGGACTTATTAAAGATCAAATTTTTGGCTCTCATCTGCACAAAGTGTGTG
AACGTGAAAATTCCACAGTTCCGTGGTTTGTAAAGCAATGCATTGAAGCTGTTGAGAAAAGAGGTCTAGATGTTGATGGAATATATCGAG
TTAGTGGCAATCTGGCAACAATACAGAAGTTAAGATTTATTGTCAACCAAGAAGAGAAGCTGAATTTGGACGACAGCCAGTGGGAGGACA
TCCACGTTGTCACCGGAGCACTGAAGATGTTTTTCCGGGAGCTGCCTGAGCCGCTCTTCCCTTACAGTTTCTTTGAGCAGTTTGTGGAAG
CGATCAAAAAGCAAGACAACAACACAAGAATTGAAGCTGTAAAATCTCTTGTACAAAAACTCCCTCCGCCAAATCGTGACACCATGAAAG
TCCTCTTTGGACATCTAACTAAGATAGTGGCCAAAGCCTCCAAGAACCTCATGTCCACGCAAAGCTTGGGGATTGTATTTGGACCTACCC
TTCTGCGAGCTGAAAATGAAACAGGAAACATGGCGATCCACATGGTCTACCAGAACCAGATAGCTGAGCTCATGCTGAGTGAGTACAGTA
AGATCTTCGGCTCAGAGGAAGACTGACAGACAAGACAAGCTACTGAATACGTTCACATCTGTCTTGATGCCTAATATTTTTACATTTCTG
TAAACATATTTCTGAAATATTTTTTGCCTTTCAAGCGACAGATGCCTCATTTTGTGAAAACTTAATGATGATTTTGTGTTTAAGTTCCAA

>63577_63577_1_PDCD10-ARHGAP15_PDCD10_chr3_167437849_ENST00000392750_ARHGAP15_chr2_143986148_ENST00000295095_length(amino acids)=399AA_BP=22
MKLRPHPWFLCPSMQSCILCLMRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNE
FLLQSDIDFIILDWFHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLK
KFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWE
DIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGP

--------------------------------------------------------------
>63577_63577_2_PDCD10-ARHGAP15_PDCD10_chr3_167437849_ENST00000392750_ARHGAP15_chr2_143986148_ENST00000409869_length(transcript)=3009nt_BP=514nt
AAGTCAGTGCCTCAGTTGCTGGTAAGGTGTAGCTGTTCTGTCCCAGTCCCCGTAGCTCTGCACCGAGCAGAAGAGGTCTAGGGTCACGCA
GGGGCCATGGCTGAGGCACTTGGGCTTGGTTCTGGCAGGCGGAGCGGACGGGGCTGAGAGCGGGGCCCTACGGGCGGAAGAGGAGCACTG
GAAGAAGGAAGAGACAAATGTTGGGGTCTACGGATTCAGTTCCAGTTTAATGATGTGGCCCTCTAAGGAGATAATTTTGCCTTAAACAGA
AAGACTTGACCCTCTTAGGTGTCATACCTAAGATCAGTGTGTTTTTTGTGTCCAATTCTTTTATCACCAAAAAAGAGAAGAAATATTGCA
GTGAATGAAGATTCCTCTGCATTTTAGCACTGCTTTTTCAACTGTAGTTGGCTTTTGAATGAGGATGACAATGGAAGAGATGAAGAATGA
AGCTGAGACCACATCCATGGTTTCTATGCCCCTCTATGCAGTCATGTATCCTGTGTTTAATGAGGAAAAACTGGTCTACTTCCTGGATTG
TTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTCTGTCCAATATGAGCTTCTGCTTGATGTGTTCAGGAGGCA
CCTGACCATGTTCATGGGATTTGGCAAATCTCCATTTTTGGTTAAACAAAACCCATTTGATGGATTGCATCATAGAGAAGAAGCTCTGCA
ATTTAGAACATCCATTCATTTATTCTCTCAACAGTTAACAACTCCTACCAGGTGTCATATAATTTTTTTCTTTTTGTTTTGTTTTGTTTT
TACATTAGGGGCAACAGAAATATTCAAATGAATAGTATATGATCCCTGCTCTTAAAGTACTCACAATATGGTAAAAGAGACATAATTTTG
TATAGGTTTATTATAATAAAACCATGACTAAAGTGTTAAAAAATATTAGACAACATGCCATGGAACCATAGATTTAGCTATAGGTAGTCT
TTTTCCAGAGAAACTATTGTTGCAAGTCATGTTCAGCTTAGGTATCTCTCCTTTTGTTCAAATATTACTGTTTGATATTATTATATCAAA
TATTATTGAGCATCTCTTATGTTTAAGTCACTACGATAGGTGTTCTGAAAGATAAAAAATGAACCAGACTGAAACAAATAGAAAGTATGG
CCTTAGATTGAGTATAGTGAAGAAATGGATGTTGGTAGTTGTCCTAAAATGGCATGAACAGAGACATGGCGTCGTTTTATGATAACTCAA
GAGAAGAGTGTGATTGCTTCCATTTGGACAGGATTTGAAATATATTCATGGAGGAAGTGACATTTGAGCACATTTCTGAAGGATGTATAG
GATTTTGATGTAAAAGGGGGCAAAAGATATTTTATGTACTAATAAGAGAGTAATTAATAGTGAACTATGGAAAATTCTTTTTTTGTTGTT
TATTTTACAGATGTATATTGATCTCTTGCCTTCTTCCATGCACTGTGTACTAGTCACTGTTCTTGAAATGTTTGAATGGGGGTTCCCTGA
GGCCTGGAGTGAATATTTCCTAGTCCAGAGTATTTTGTGTTTCTTCTCTAAGTTGCCTGGGAGTGAGGAACAGCTTTAGACTAAGTTGCG
GAACAGCATTGTGGAACAGCAAACAGTGTAATTTGGTTAGAAAGTCAGTGTGGAACCGGTTTAGGAAAGACTTTGAACAGGATTGGGAGA
AGAGATCATTTCATTCTGTAGGTAATGTGGGGTTTTTGTAACCAATATGAAATATTCTCAAATTAAGAGAGACTCAGAGTTTTCAGAGAC
ATGTTTAGGGAACTGATATATATATCAGTTGTCTATAAAATTAAGTCTCTCTTAATTTTGTGTATATATAACTTAAAAACACATGCAGGA
CTTGGTAAATTATCCGAGAGACATGTTCTAAAAATTTATGCAAATAGATGTGAGCAATAAGGCCTGAGCTCTTACGACAGAGAAAATTGT
AAAACGGCTGTGTGTCATCATTTTGGCTCAATGCATTTAGTAAATCACAGGACATCTTTTCACTGACAAAATATTTTGATATTCTCATAT
GTCTCTGACCTCCAACAGTATGGCCATTTCTAAAGACGTTCTAGTGCAAAGAGAACAAGCAGAGCTATCCATCTAAGGAGAGCGAAAAAC
ATGCTGTCCCAAGAACTAGGTGTGTCACCATCTCAGTGAGCACCCGTTGCAAACCTACTGGTGCTTCCATCTGACTCCAGAACATCTGTT
TAGTGTCACACCCTACTTAAACAAATGCATTGTGTGAAGTCTTTCCACCAACAATCAGACGCTGTGGAACTCATTGTCACCAATTGGGTG
GATGAGAGCCACCGTTTCTATTATATTCATCACACACTGCTCAGAAAATTTAGTGTCACTTTTGATATAAATTCAAAAACATTGTAAACA
TTTTAGGGAATATTTTCCCCCTAAAATGGTGTGGTTCTAAAGCCAGTATATTCAGTAGAAAGCCTATATGTTGGTTGTGTAAGGGACTTT
TTTGTTACTCTTATGTTTTTTATTTTACATTGTACTAATATGTATTTTTAATCAGAGCCAACAACTGGCAATTTTTACTTTTTAAAAATT
ATATTTTTGGGTTTTACATTTAAGTCTTTAATCCATCTTGAGTTAATTTTTGTATATGGTGTAAGGAAGGGGTCCAGTTTCAATTTTCTG
CATATGGTTACCCAGTTCCCCACATTTATTAAATAAACTATAAAAACTCTAGAATGAAATCTAGGCAATACCATTCAGGACATAGGCACA
GACAAAGATTTTATGATGAAAATGCCAAAAGCAATTGTAATAAAAGCAAATGGTGACAAATGGGGTCTAATTAAACTAAAGAGCTTCCGC
ACAGCAAAAGTAACTATCATCAGAGTGAACAGACAACTTTCAGAATGGGAGACAATTTTTGCAATCTATTCAGCTGACAAAATTCTAATA

>63577_63577_2_PDCD10-ARHGAP15_PDCD10_chr3_167437849_ENST00000392750_ARHGAP15_chr2_143986148_ENST00000409869_length(amino acids)=77AA_BP=

--------------------------------------------------------------
>63577_63577_3_PDCD10-ARHGAP15_PDCD10_chr3_167437849_ENST00000461494_ARHGAP15_chr2_143986148_ENST00000295095_length(transcript)=1637nt_BP=325nt
AGGTTGGCCCCTGGTGCCCCGGGAGAGGGGACAGGGCGGATGTGCCTGGGGTGGGGTCCTTTGAAGGTGTGGCTTCGGACCGAGAGGTGA
GGCTGCTGTTTTCCCCCTGCTTTATCAGTGTGTTTTTTGTGTCCAATTCTTTTATCACCAAAAAAGAGAAGAAATATTGCAGTGAATGAA
GATTCCTCTGCATTTTAGCACTGCTTTTTCAACTGTAGTTGGCTTTTGAATGAGGATGACAATGGAAGAGATGAAGAATGAAGCTGAGAC
CACATCCATGGTTTCTATGCCCCTCTATGCAGTCATGTATCCTGTGTTTAATGAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTA
GTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTCTGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGTG
GAGCACACATTGAATGGGCCAAGGAAAAATCGAGCAGAAAGAATGTCTTTCAGATCACAACAGTATCAGGAAATGAGTTCCTTCTACAGT
CAGATATTGACTTCATCATATTGGATTGGTTCCACGCTATCAAAAATGCAATTGACAGATTGCCAAAGGATTCAAGTTGTCCATCAAGAA
ACCTGGAATTATTCAAAATCCAAAGATCCTCTAGCACTGAATTGCTAAGTCACTACGACAGTGATATAAAAGAACAGAAACCAGAGCACA
GAAAATCTTTAATGTTCAGACTGCATCACAGTGCTTCCGATACAAGCGACAAAAATCGAGTTAAAAGCAGATTAAAGAAGTTTATTACCC
GAAGACCTTCCCTGAAAACTCTGCAAGAAAAAGGACTTATTAAAGATCAAATTTTTGGCTCTCATCTGCACAAAGTGTGTGAACGTGAAA
ATTCCACAGTTCCGTGGTTTGTAAAGCAATGCATTGAAGCTGTTGAGAAAAGAGGTCTAGATGTTGATGGAATATATCGAGTTAGTGGCA
ATCTGGCAACAATACAGAAGTTAAGATTTATTGTCAACCAAGAAGAGAAGCTGAATTTGGACGACAGCCAGTGGGAGGACATCCACGTTG
TCACCGGAGCACTGAAGATGTTTTTCCGGGAGCTGCCTGAGCCGCTCTTCCCTTACAGTTTCTTTGAGCAGTTTGTGGAAGCGATCAAAA
AGCAAGACAACAACACAAGAATTGAAGCTGTAAAATCTCTTGTACAAAAACTCCCTCCGCCAAATCGTGACACCATGAAAGTCCTCTTTG
GACATCTAACTAAGATAGTGGCCAAAGCCTCCAAGAACCTCATGTCCACGCAAAGCTTGGGGATTGTATTTGGACCTACCCTTCTGCGAG
CTGAAAATGAAACAGGAAACATGGCGATCCACATGGTCTACCAGAACCAGATAGCTGAGCTCATGCTGAGTGAGTACAGTAAGATCTTCG
GCTCAGAGGAAGACTGACAGACAAGACAAGCTACTGAATACGTTCACATCTGTCTTGATGCCTAATATTTTTACATTTCTGTAAACATAT
TTCTGAAATATTTTTTGCCTTTCAAGCGACAGATGCCTCATTTTGTGAAAACTTAATGATGATTTTGTGTTTAAGTTCCAAACATTTGAA

>63577_63577_3_PDCD10-ARHGAP15_PDCD10_chr3_167437849_ENST00000461494_ARHGAP15_chr2_143986148_ENST00000295095_length(amino acids)=399AA_BP=22
MKLRPHPWFLCPSMQSCILCLMRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNE
FLLQSDIDFIILDWFHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLK
KFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWE
DIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGP

--------------------------------------------------------------
>63577_63577_4_PDCD10-ARHGAP15_PDCD10_chr3_167437849_ENST00000461494_ARHGAP15_chr2_143986148_ENST00000409869_length(transcript)=2820nt_BP=325nt
AGGTTGGCCCCTGGTGCCCCGGGAGAGGGGACAGGGCGGATGTGCCTGGGGTGGGGTCCTTTGAAGGTGTGGCTTCGGACCGAGAGGTGA
GGCTGCTGTTTTCCCCCTGCTTTATCAGTGTGTTTTTTGTGTCCAATTCTTTTATCACCAAAAAAGAGAAGAAATATTGCAGTGAATGAA
GATTCCTCTGCATTTTAGCACTGCTTTTTCAACTGTAGTTGGCTTTTGAATGAGGATGACAATGGAAGAGATGAAGAATGAAGCTGAGAC
CACATCCATGGTTTCTATGCCCCTCTATGCAGTCATGTATCCTGTGTTTAATGAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTA
GTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTCTGTCCAATATGAGCTTCTGCTTGATGTGTTCAGGAGGCACCTGACCAT
GTTCATGGGATTTGGCAAATCTCCATTTTTGGTTAAACAAAACCCATTTGATGGATTGCATCATAGAGAAGAAGCTCTGCAATTTAGAAC
ATCCATTCATTTATTCTCTCAACAGTTAACAACTCCTACCAGGTGTCATATAATTTTTTTCTTTTTGTTTTGTTTTGTTTTTACATTAGG
GGCAACAGAAATATTCAAATGAATAGTATATGATCCCTGCTCTTAAAGTACTCACAATATGGTAAAAGAGACATAATTTTGTATAGGTTT
ATTATAATAAAACCATGACTAAAGTGTTAAAAAATATTAGACAACATGCCATGGAACCATAGATTTAGCTATAGGTAGTCTTTTTCCAGA
GAAACTATTGTTGCAAGTCATGTTCAGCTTAGGTATCTCTCCTTTTGTTCAAATATTACTGTTTGATATTATTATATCAAATATTATTGA
GCATCTCTTATGTTTAAGTCACTACGATAGGTGTTCTGAAAGATAAAAAATGAACCAGACTGAAACAAATAGAAAGTATGGCCTTAGATT
GAGTATAGTGAAGAAATGGATGTTGGTAGTTGTCCTAAAATGGCATGAACAGAGACATGGCGTCGTTTTATGATAACTCAAGAGAAGAGT
GTGATTGCTTCCATTTGGACAGGATTTGAAATATATTCATGGAGGAAGTGACATTTGAGCACATTTCTGAAGGATGTATAGGATTTTGAT
GTAAAAGGGGGCAAAAGATATTTTATGTACTAATAAGAGAGTAATTAATAGTGAACTATGGAAAATTCTTTTTTTGTTGTTTATTTTACA
GATGTATATTGATCTCTTGCCTTCTTCCATGCACTGTGTACTAGTCACTGTTCTTGAAATGTTTGAATGGGGGTTCCCTGAGGCCTGGAG
TGAATATTTCCTAGTCCAGAGTATTTTGTGTTTCTTCTCTAAGTTGCCTGGGAGTGAGGAACAGCTTTAGACTAAGTTGCGGAACAGCAT
TGTGGAACAGCAAACAGTGTAATTTGGTTAGAAAGTCAGTGTGGAACCGGTTTAGGAAAGACTTTGAACAGGATTGGGAGAAGAGATCAT
TTCATTCTGTAGGTAATGTGGGGTTTTTGTAACCAATATGAAATATTCTCAAATTAAGAGAGACTCAGAGTTTTCAGAGACATGTTTAGG
GAACTGATATATATATCAGTTGTCTATAAAATTAAGTCTCTCTTAATTTTGTGTATATATAACTTAAAAACACATGCAGGACTTGGTAAA
TTATCCGAGAGACATGTTCTAAAAATTTATGCAAATAGATGTGAGCAATAAGGCCTGAGCTCTTACGACAGAGAAAATTGTAAAACGGCT
GTGTGTCATCATTTTGGCTCAATGCATTTAGTAAATCACAGGACATCTTTTCACTGACAAAATATTTTGATATTCTCATATGTCTCTGAC
CTCCAACAGTATGGCCATTTCTAAAGACGTTCTAGTGCAAAGAGAACAAGCAGAGCTATCCATCTAAGGAGAGCGAAAAACATGCTGTCC
CAAGAACTAGGTGTGTCACCATCTCAGTGAGCACCCGTTGCAAACCTACTGGTGCTTCCATCTGACTCCAGAACATCTGTTTAGTGTCAC
ACCCTACTTAAACAAATGCATTGTGTGAAGTCTTTCCACCAACAATCAGACGCTGTGGAACTCATTGTCACCAATTGGGTGGATGAGAGC
CACCGTTTCTATTATATTCATCACACACTGCTCAGAAAATTTAGTGTCACTTTTGATATAAATTCAAAAACATTGTAAACATTTTAGGGA
ATATTTTCCCCCTAAAATGGTGTGGTTCTAAAGCCAGTATATTCAGTAGAAAGCCTATATGTTGGTTGTGTAAGGGACTTTTTTGTTACT
CTTATGTTTTTTATTTTACATTGTACTAATATGTATTTTTAATCAGAGCCAACAACTGGCAATTTTTACTTTTTAAAAATTATATTTTTG
GGTTTTACATTTAAGTCTTTAATCCATCTTGAGTTAATTTTTGTATATGGTGTAAGGAAGGGGTCCAGTTTCAATTTTCTGCATATGGTT
ACCCAGTTCCCCACATTTATTAAATAAACTATAAAAACTCTAGAATGAAATCTAGGCAATACCATTCAGGACATAGGCACAGACAAAGAT
TTTATGATGAAAATGCCAAAAGCAATTGTAATAAAAGCAAATGGTGACAAATGGGGTCTAATTAAACTAAAGAGCTTCCGCACAGCAAAA
GTAACTATCATCAGAGTGAACAGACAACTTTCAGAATGGGAGACAATTTTTGCAATCTATTCAGCTGACAAAATTCTAATATCCAGAGTC

>63577_63577_4_PDCD10-ARHGAP15_PDCD10_chr3_167437849_ENST00000461494_ARHGAP15_chr2_143986148_ENST00000409869_length(amino acids)=77AA_BP=

--------------------------------------------------------------
>63577_63577_5_PDCD10-ARHGAP15_PDCD10_chr3_167437849_ENST00000487947_ARHGAP15_chr2_143986148_ENST00000295095_length(transcript)=1548nt_BP=236nt
GAAGGTGTGGCTTCGGACCGAGAGATCAGTGTGTTTTTTGTGTCCAATTCTTTTATCACCAAAAAAGAGAAGAAATATTGCAGTGAATGA
AGATTCCTCTGCATTTTAGCACTGCTTTTTCAACTGTAGTTGGCTTTTGAATGAGGATGACAATGGAAGAGATGAAGAATGAAGCTGAGA
CCACATCCATGGTTTCTATGCCCCTCTATGCAGTCATGTATCCTGTGTTTAATGAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCT
AGTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTCTGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGT
GGAGCACACATTGAATGGGCCAAGGAAAAATCGAGCAGAAAGAATGTCTTTCAGATCACAACAGTATCAGGAAATGAGTTCCTTCTACAG
TCAGATATTGACTTCATCATATTGGATTGGTTCCACGCTATCAAAAATGCAATTGACAGATTGCCAAAGGATTCAAGTTGTCCATCAAGA
AACCTGGAATTATTCAAAATCCAAAGATCCTCTAGCACTGAATTGCTAAGTCACTACGACAGTGATATAAAAGAACAGAAACCAGAGCAC
AGAAAATCTTTAATGTTCAGACTGCATCACAGTGCTTCCGATACAAGCGACAAAAATCGAGTTAAAAGCAGATTAAAGAAGTTTATTACC
CGAAGACCTTCCCTGAAAACTCTGCAAGAAAAAGGACTTATTAAAGATCAAATTTTTGGCTCTCATCTGCACAAAGTGTGTGAACGTGAA
AATTCCACAGTTCCGTGGTTTGTAAAGCAATGCATTGAAGCTGTTGAGAAAAGAGGTCTAGATGTTGATGGAATATATCGAGTTAGTGGC
AATCTGGCAACAATACAGAAGTTAAGATTTATTGTCAACCAAGAAGAGAAGCTGAATTTGGACGACAGCCAGTGGGAGGACATCCACGTT
GTCACCGGAGCACTGAAGATGTTTTTCCGGGAGCTGCCTGAGCCGCTCTTCCCTTACAGTTTCTTTGAGCAGTTTGTGGAAGCGATCAAA
AAGCAAGACAACAACACAAGAATTGAAGCTGTAAAATCTCTTGTACAAAAACTCCCTCCGCCAAATCGTGACACCATGAAAGTCCTCTTT
GGACATCTAACTAAGATAGTGGCCAAAGCCTCCAAGAACCTCATGTCCACGCAAAGCTTGGGGATTGTATTTGGACCTACCCTTCTGCGA
GCTGAAAATGAAACAGGAAACATGGCGATCCACATGGTCTACCAGAACCAGATAGCTGAGCTCATGCTGAGTGAGTACAGTAAGATCTTC
GGCTCAGAGGAAGACTGACAGACAAGACAAGCTACTGAATACGTTCACATCTGTCTTGATGCCTAATATTTTTACATTTCTGTAAACATA
TTTCTGAAATATTTTTTGCCTTTCAAGCGACAGATGCCTCATTTTGTGAAAACTTAATGATGATTTTGTGTTTAAGTTCCAAACATTTGA

>63577_63577_5_PDCD10-ARHGAP15_PDCD10_chr3_167437849_ENST00000487947_ARHGAP15_chr2_143986148_ENST00000295095_length(amino acids)=399AA_BP=22
MKLRPHPWFLCPSMQSCILCLMRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNE
FLLQSDIDFIILDWFHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLK
KFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWE
DIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGP

--------------------------------------------------------------
>63577_63577_6_PDCD10-ARHGAP15_PDCD10_chr3_167437849_ENST00000487947_ARHGAP15_chr2_143986148_ENST00000409869_length(transcript)=2731nt_BP=236nt
GAAGGTGTGGCTTCGGACCGAGAGATCAGTGTGTTTTTTGTGTCCAATTCTTTTATCACCAAAAAAGAGAAGAAATATTGCAGTGAATGA
AGATTCCTCTGCATTTTAGCACTGCTTTTTCAACTGTAGTTGGCTTTTGAATGAGGATGACAATGGAAGAGATGAAGAATGAAGCTGAGA
CCACATCCATGGTTTCTATGCCCCTCTATGCAGTCATGTATCCTGTGTTTAATGAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCT
AGTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTCTGTCCAATATGAGCTTCTGCTTGATGTGTTCAGGAGGCACCTGACCA
TGTTCATGGGATTTGGCAAATCTCCATTTTTGGTTAAACAAAACCCATTTGATGGATTGCATCATAGAGAAGAAGCTCTGCAATTTAGAA
CATCCATTCATTTATTCTCTCAACAGTTAACAACTCCTACCAGGTGTCATATAATTTTTTTCTTTTTGTTTTGTTTTGTTTTTACATTAG
GGGCAACAGAAATATTCAAATGAATAGTATATGATCCCTGCTCTTAAAGTACTCACAATATGGTAAAAGAGACATAATTTTGTATAGGTT
TATTATAATAAAACCATGACTAAAGTGTTAAAAAATATTAGACAACATGCCATGGAACCATAGATTTAGCTATAGGTAGTCTTTTTCCAG
AGAAACTATTGTTGCAAGTCATGTTCAGCTTAGGTATCTCTCCTTTTGTTCAAATATTACTGTTTGATATTATTATATCAAATATTATTG
AGCATCTCTTATGTTTAAGTCACTACGATAGGTGTTCTGAAAGATAAAAAATGAACCAGACTGAAACAAATAGAAAGTATGGCCTTAGAT
TGAGTATAGTGAAGAAATGGATGTTGGTAGTTGTCCTAAAATGGCATGAACAGAGACATGGCGTCGTTTTATGATAACTCAAGAGAAGAG
TGTGATTGCTTCCATTTGGACAGGATTTGAAATATATTCATGGAGGAAGTGACATTTGAGCACATTTCTGAAGGATGTATAGGATTTTGA
TGTAAAAGGGGGCAAAAGATATTTTATGTACTAATAAGAGAGTAATTAATAGTGAACTATGGAAAATTCTTTTTTTGTTGTTTATTTTAC
AGATGTATATTGATCTCTTGCCTTCTTCCATGCACTGTGTACTAGTCACTGTTCTTGAAATGTTTGAATGGGGGTTCCCTGAGGCCTGGA
GTGAATATTTCCTAGTCCAGAGTATTTTGTGTTTCTTCTCTAAGTTGCCTGGGAGTGAGGAACAGCTTTAGACTAAGTTGCGGAACAGCA
TTGTGGAACAGCAAACAGTGTAATTTGGTTAGAAAGTCAGTGTGGAACCGGTTTAGGAAAGACTTTGAACAGGATTGGGAGAAGAGATCA
TTTCATTCTGTAGGTAATGTGGGGTTTTTGTAACCAATATGAAATATTCTCAAATTAAGAGAGACTCAGAGTTTTCAGAGACATGTTTAG
GGAACTGATATATATATCAGTTGTCTATAAAATTAAGTCTCTCTTAATTTTGTGTATATATAACTTAAAAACACATGCAGGACTTGGTAA
ATTATCCGAGAGACATGTTCTAAAAATTTATGCAAATAGATGTGAGCAATAAGGCCTGAGCTCTTACGACAGAGAAAATTGTAAAACGGC
TGTGTGTCATCATTTTGGCTCAATGCATTTAGTAAATCACAGGACATCTTTTCACTGACAAAATATTTTGATATTCTCATATGTCTCTGA
CCTCCAACAGTATGGCCATTTCTAAAGACGTTCTAGTGCAAAGAGAACAAGCAGAGCTATCCATCTAAGGAGAGCGAAAAACATGCTGTC
CCAAGAACTAGGTGTGTCACCATCTCAGTGAGCACCCGTTGCAAACCTACTGGTGCTTCCATCTGACTCCAGAACATCTGTTTAGTGTCA
CACCCTACTTAAACAAATGCATTGTGTGAAGTCTTTCCACCAACAATCAGACGCTGTGGAACTCATTGTCACCAATTGGGTGGATGAGAG
CCACCGTTTCTATTATATTCATCACACACTGCTCAGAAAATTTAGTGTCACTTTTGATATAAATTCAAAAACATTGTAAACATTTTAGGG
AATATTTTCCCCCTAAAATGGTGTGGTTCTAAAGCCAGTATATTCAGTAGAAAGCCTATATGTTGGTTGTGTAAGGGACTTTTTTGTTAC
TCTTATGTTTTTTATTTTACATTGTACTAATATGTATTTTTAATCAGAGCCAACAACTGGCAATTTTTACTTTTTAAAAATTATATTTTT
GGGTTTTACATTTAAGTCTTTAATCCATCTTGAGTTAATTTTTGTATATGGTGTAAGGAAGGGGTCCAGTTTCAATTTTCTGCATATGGT
TACCCAGTTCCCCACATTTATTAAATAAACTATAAAAACTCTAGAATGAAATCTAGGCAATACCATTCAGGACATAGGCACAGACAAAGA
TTTTATGATGAAAATGCCAAAAGCAATTGTAATAAAAGCAAATGGTGACAAATGGGGTCTAATTAAACTAAAGAGCTTCCGCACAGCAAA
AGTAACTATCATCAGAGTGAACAGACAACTTTCAGAATGGGAGACAATTTTTGCAATCTATTCAGCTGACAAAATTCTAATATCCAGAGT

>63577_63577_6_PDCD10-ARHGAP15_PDCD10_chr3_167437849_ENST00000487947_ARHGAP15_chr2_143986148_ENST00000409869_length(amino acids)=77AA_BP=

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PDCD10-ARHGAP15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDCD10-ARHGAP15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDCD10-ARHGAP15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource