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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDCD6IP-NGLY1 (FusionGDB2 ID:63615)

Fusion Gene Summary for PDCD6IP-NGLY1

check button Fusion gene summary
Fusion gene informationFusion gene name: PDCD6IP-NGLY1
Fusion gene ID: 63615
HgeneTgene
Gene symbol

PDCD6IP

NGLY1

Gene ID

10015

55768

Gene nameprogrammed cell death 6 interacting proteinN-glycanase 1
SynonymsAIP1|ALIX|DRIP4|HP95CDDG|CDG1V|PNG-1|PNG1|PNGase
Cytomap

3p22.3

3p24.2

Type of geneprotein-codingprotein-coding
Descriptionprogrammed cell death 6-interacting proteinALG-2 interacting protein 1ALG-2-interacting protein XPDCD6-interacting proteinapoptosis-linked gene 2-interacting protein Xdopamine receptor interacting protein 4peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidasehPNGasepeptide:N-glycanase
Modification date2020031320200313
UniProtAcc.

Q96IV0

Ensembl transtripts involved in fusion geneENST00000307296, ENST00000457054, 
ENST00000498147, 		ENST00000422724, 
ENST00000467224, ENST00000280700, 
ENST00000396649, ENST00000417874, 
ENST00000428257, 
Fusion gene scores* DoF score7 X 6 X 4=1686 X 5 X 4=120
# samples 76
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDCD6IP [Title/Abstract] AND NGLY1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDCD6IP(33870461)-NGLY1(25792754), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDCD6IP

GO:0000281

mitotic cytokinesis

18641129

HgenePDCD6IP

GO:0046755

viral budding

18641129

HgenePDCD6IP

GO:0051260

protein homooligomerization

18641129

TgeneNGLY1

GO:0006516

glycoprotein catabolic process

15358861

TgeneNGLY1

GO:0006517

protein deglycosylation

28826503


check buttonFusion gene breakpoints across PDCD6IP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NGLY1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8531-01APDCD6IPchr3

33870461

+NGLY1chr3

25792754

-


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Fusion Gene ORF analysis for PDCD6IP-NGLY1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000307296ENST00000422724PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
5CDS-intronENST00000307296ENST00000467224PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
5CDS-intronENST00000457054ENST00000422724PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
5CDS-intronENST00000457054ENST00000467224PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
In-frameENST00000307296ENST00000280700PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
In-frameENST00000307296ENST00000396649PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
In-frameENST00000307296ENST00000417874PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
In-frameENST00000307296ENST00000428257PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
In-frameENST00000457054ENST00000280700PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
In-frameENST00000457054ENST00000396649PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
In-frameENST00000457054ENST00000417874PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
In-frameENST00000457054ENST00000428257PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
intron-3CDSENST00000498147ENST00000280700PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
intron-3CDSENST00000498147ENST00000396649PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
intron-3CDSENST00000498147ENST00000417874PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
intron-3CDSENST00000498147ENST00000428257PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
intron-intronENST00000498147ENST00000422724PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-
intron-intronENST00000498147ENST00000467224PDCD6IPchr3

33870461

+NGLY1chr3

25792754

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000307296PDCD6IPchr333870461+ENST00000428257NGLY1chr325792754-314512112152629804
ENST00000307296PDCD6IPchr333870461+ENST00000280700NGLY1chr325792754-303112112152683822
ENST00000307296PDCD6IPchr333870461+ENST00000396649NGLY1chr325792754-269512112152395726
ENST00000307296PDCD6IPchr333870461+ENST00000417874NGLY1chr325792754-273312112152683822
ENST00000457054PDCD6IPchr333870461+ENST00000428257NGLY1chr325792754-29381004142422802
ENST00000457054PDCD6IPchr333870461+ENST00000280700NGLY1chr325792754-28241004142476820
ENST00000457054PDCD6IPchr333870461+ENST00000396649NGLY1chr325792754-24881004142188724
ENST00000457054PDCD6IPchr333870461+ENST00000417874NGLY1chr325792754-25261004142476820

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000307296ENST00000428257PDCD6IPchr333870461+NGLY1chr325792754-0.0003427370.9996573
ENST00000307296ENST00000280700PDCD6IPchr333870461+NGLY1chr325792754-0.0005037350.9994962
ENST00000307296ENST00000396649PDCD6IPchr333870461+NGLY1chr325792754-0.0007847990.9992151
ENST00000307296ENST00000417874PDCD6IPchr333870461+NGLY1chr325792754-0.0008285410.9991715
ENST00000457054ENST00000428257PDCD6IPchr333870461+NGLY1chr325792754-0.0003863220.9996137
ENST00000457054ENST00000280700PDCD6IPchr333870461+NGLY1chr325792754-0.0007245940.9992754
ENST00000457054ENST00000396649PDCD6IPchr333870461+NGLY1chr325792754-0.001131530.99886847
ENST00000457054ENST00000417874PDCD6IPchr333870461+NGLY1chr325792754-0.0012349460.9987651

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Fusion Genomic Features for PDCD6IP-NGLY1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDCD6IP-NGLY1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:33870461/chr3:25792754)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NGLY1

Q96IV0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. {ECO:0000269|PubMed:14749736, ECO:0000269|PubMed:15358861}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNGLY1chr3:33870461chr3:25792754ENST00000280700212454_654164655.0DomainPAW
TgeneNGLY1chr3:33870461chr3:25792754ENST00000396649211454_654164559.0DomainPAW
TgeneNGLY1chr3:33870461chr3:25792754ENST00000417874212454_654122613.0DomainPAW
TgeneNGLY1chr3:33870461chr3:25792754ENST00000428257212454_654164637.0DomainPAW

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000307296+718717_860278869.0Compositional biasNote=Pro-rich
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000457054+718717_860283874.0Compositional biasNote=Pro-rich
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000307296+7183_392278869.0DomainBRO1
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000457054+7183_392283874.0DomainBRO1
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000307296+718503_868278869.0RegionNote=Self-association
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000307296+718864_868278869.0RegionNote=Essential to promote virus budding
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000457054+718503_868283874.0RegionNote=Self-association
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000457054+718864_868283874.0RegionNote=Essential to promote virus budding
TgeneNGLY1chr3:33870461chr3:25792754ENST0000028070021230_91164655.0DomainNote=PUB
TgeneNGLY1chr3:33870461chr3:25792754ENST0000039664921130_91164559.0DomainNote=PUB
TgeneNGLY1chr3:33870461chr3:25792754ENST0000041787421230_91122613.0DomainNote=PUB
TgeneNGLY1chr3:33870461chr3:25792754ENST0000042825721230_91164637.0DomainNote=PUB


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Fusion Gene Sequence for PDCD6IP-NGLY1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63615_63615_1_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000307296_NGLY1_chr3_25792754_ENST00000280700_length(transcript)=3031nt_BP=1211nt
AGTACTTCTCCGGGGGGTTGTTCGAGTGGAGGAATACTCTTACGTGAAAGTGCTCAGTACACCACTGCGGCAGGAAGGAGGAAGGGAAGA
ATTCCAGATGGGGAGAAAGTAATATTTTGCAGCACAGTACAGGGTAAACTGGGTCCAGGTGGGCGTAGCCGCCGCGACACCTTCACGTGA
CCGCGGACAGCTTAAGGACCCCGCATCCAGTGCGCCTGCGCTGGAGCTCCCGGAAGTTGCCGGACCCGGAACGCAGGCGGAGCGCAAGTC
TGTCAGCCAGTCAGTCCGCCAGTCCGCCAGCCCAGTACCTCTCTCTCCTCGGCCCTCGTAAGCTGTCCGCGGTCTGTTTGGCCCGAACGG
CGGCGGAGGCGCTGATCATGGCGACATTCATCTCGGTGCAGCTGAAAAAGACCTCAGAGGTGGACCTGGCCAAGCCGCTGGTGAAGTTCA
TCCAGCAGACTTACCCAAGCGGCGGGGAAGAGCAGGCCCAGTACTGCCGCGCGGCGGAGGAGCTCAGCAAGCTGCGCCGCGCCGCAGTCG
GTCGTCCGCTGGACAAGCACGAGGGCGCGCTCGAGACGCTCCTGAGATATTATGATCAGATTTGTTCTATTGAACCCAAATTCCCATTTT
CTGAAAATCAGATCTGCTTGACATTTACCTGGAAGGATGCTTTCGATAAAGGTTCACTTTTTGGAGGCTCTGTAAAACTGGCTCTTGCAA
GCTTAGGATATGAAAAGAGCTGTGTGTTGTTCAATTGTGCAGCCTTAGCTAGCCAAATTGCAGCAGAACAGAACCTGGATAATGATGAAG
GATTGAAAATCGCTGCTAAACATTACCAGTTTGCTAGTGGTGCCTTTTTACATATTAAAGAGACGGTTTTATCTGCCTTAAGTCGAGAGC
CGACCGTGGACATATCTCCAGATACTGTTGGGACCCTCAGTCTTATTATGCTGGCACAGGCTCAAGAAGTATTTTTTTTAAAAGCCACAA
GAGATAAAATGAAAGATGCCATCATAGCTAAATTGGCTAATCAGGCTGCAGATTATTTTGGTGATGCTTTCAAACAGTGTCAATACAAAG
ATACTCTCCCCAAGGAGGTGTTCCCTGTCTTGGCTGCAAAGCACTGTATCATGCAGGCCAATGCTGAGTACCATCAGTCTATCCTGGCAA
AACAGCAGAAGAAATTTGGAGAAGAAATTGCAAGGTTACAGGTTGCTGCTGACTCAGCCATTCTAGAAGTTCTTCAGTCCAACATTCAGC
ATGTGCTGGTCTATGAAAATCCTGCTCTTCAGGAGAAAGCGTTGGCTTGTATTCCGGTCCAAGAACTAAAAAGGAAATCACAAGAAAAGT
TATCGAGAGCTAGAAAATTGGATAAAGGTATCAATATAAGTGATGAGGATTTTCTTTTGCTGGAGCTTTTGCACTGGTTTAAGGAAGAAT
TTTTTCACTGGGTGAATAACGTTTTGTGCAGCAAATGTGGTGGACAGACTAGGTCTAGAGATAGATCATTACTGCCCAGTGATGATGAGC
TGAAGTGGGGTGCAAAGGAAGTGGAAGATCATTACTGTGATGCCTGCCAGTTCAGCAATCGATTCCCAAGATATAATAACCCTGAGAAAC
TTTTGGAAACAAGATGTGGACGGTGTGGCGAGTGGGCCAATTGTTTTACACTGTGCTGCCGAGCTGTAGGGTTTGAAGCTCGCTATGTTT
GGGATTACACAGACCATGTCTGGACAGAAGTCTATTCTCCTTCTCAGCAGCGGTGGCTGCACTGTGATGCATGTGAAGATGTCTGTGACA
AGCCACTCCTTTATGAAATAGGATGGGGCAAGAAGCTTTCCTATGTCATAGCATTTTCAAAAGATGAGGTAGTTGATGTCACTTGGCGAT
ATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATTACTTCGAGACACTATTAATGGGCTTAATAAGCAGA
GGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGTGGAGCTTGTTGAATTTATATCTCCCAAAACCCCTA
AACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGAAATGGGTCTACAGAGAAAAGAAACCTTGT
TTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATATTGTGAAAGATCGTTATGTTCGAGTTTCAAATAACA
ATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAGAAAAGTTGAAACAGACTGGCACATGGTATATTTGG
CCCGAAAGGAAGGATCATCTTTTGCTTATATTTCCTGGAAGTTTGAGTGTGGGTCAGTTGGCCTAAAAGTAGATAGCATTTCTATTAGAA
CAAGTAGTCAAACTTTTCAGACTGGAACAGTAGAATGGAAATTGCGATCTGATACAGCACAAGTAGAACTGACAGGCGATAACAGTCTTC
ACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGGAGATGGTGATGTCGCTTGGCAACACACCC
AGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTATAAAATTCAGTGACCTTTGAGAACCTGAACATTATA
GAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCATGCTTAGTTGGCAGTTACCACCCTGTGCTAGCATATT
TCTTTTGCTAGCTATCCATCATGTAACCCTCATGAAAATTATCTTTATACGTGGACTATAATAAAATATTGAATTAAAACCTTTCTTCCA
TATGTGACTATAATTTGGAGTAAAGTCTTGTTGACTCAATATGGGATTTTAATCTAAAACTGTAAGTATGGTTTTAAAAGTTAAATAATG

>63615_63615_1_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000307296_NGLY1_chr3_25792754_ENST00000280700_length(amino acids)=822AA_BP=332
MRWSSRKLPDPERRRSASLSASQSASPPAQYLSLLGPRKLSAVCLARTAAEALIMATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQ
AQYCRAAEELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFN
CAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKL
ANQAADYFGDAFKQCQYKDTLPKEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQVAADSAILEVLQSNIQHVLVYENPALQE
KALACIPVQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSRDRSLLPSDDELKWGAKEVEDHY
CDACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGFEARYVWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKK
LSYVIAFSKDEVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGS
VAWRVARGEMGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMVYLARKEGSSFAYIS
WKFECGSVGLKVDSISIRTSSQTFQTGTVEWKLRSDTAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEE

--------------------------------------------------------------
>63615_63615_2_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000307296_NGLY1_chr3_25792754_ENST00000396649_length(transcript)=2695nt_BP=1211nt
AGTACTTCTCCGGGGGGTTGTTCGAGTGGAGGAATACTCTTACGTGAAAGTGCTCAGTACACCACTGCGGCAGGAAGGAGGAAGGGAAGA
ATTCCAGATGGGGAGAAAGTAATATTTTGCAGCACAGTACAGGGTAAACTGGGTCCAGGTGGGCGTAGCCGCCGCGACACCTTCACGTGA
CCGCGGACAGCTTAAGGACCCCGCATCCAGTGCGCCTGCGCTGGAGCTCCCGGAAGTTGCCGGACCCGGAACGCAGGCGGAGCGCAAGTC
TGTCAGCCAGTCAGTCCGCCAGTCCGCCAGCCCAGTACCTCTCTCTCCTCGGCCCTCGTAAGCTGTCCGCGGTCTGTTTGGCCCGAACGG
CGGCGGAGGCGCTGATCATGGCGACATTCATCTCGGTGCAGCTGAAAAAGACCTCAGAGGTGGACCTGGCCAAGCCGCTGGTGAAGTTCA
TCCAGCAGACTTACCCAAGCGGCGGGGAAGAGCAGGCCCAGTACTGCCGCGCGGCGGAGGAGCTCAGCAAGCTGCGCCGCGCCGCAGTCG
GTCGTCCGCTGGACAAGCACGAGGGCGCGCTCGAGACGCTCCTGAGATATTATGATCAGATTTGTTCTATTGAACCCAAATTCCCATTTT
CTGAAAATCAGATCTGCTTGACATTTACCTGGAAGGATGCTTTCGATAAAGGTTCACTTTTTGGAGGCTCTGTAAAACTGGCTCTTGCAA
GCTTAGGATATGAAAAGAGCTGTGTGTTGTTCAATTGTGCAGCCTTAGCTAGCCAAATTGCAGCAGAACAGAACCTGGATAATGATGAAG
GATTGAAAATCGCTGCTAAACATTACCAGTTTGCTAGTGGTGCCTTTTTACATATTAAAGAGACGGTTTTATCTGCCTTAAGTCGAGAGC
CGACCGTGGACATATCTCCAGATACTGTTGGGACCCTCAGTCTTATTATGCTGGCACAGGCTCAAGAAGTATTTTTTTTAAAAGCCACAA
GAGATAAAATGAAAGATGCCATCATAGCTAAATTGGCTAATCAGGCTGCAGATTATTTTGGTGATGCTTTCAAACAGTGTCAATACAAAG
ATACTCTCCCCAAGGAGGTGTTCCCTGTCTTGGCTGCAAAGCACTGTATCATGCAGGCCAATGCTGAGTACCATCAGTCTATCCTGGCAA
AACAGCAGAAGAAATTTGGAGAAGAAATTGCAAGGTTACAGGTTGCTGCTGACTCAGCCATTCTAGAAGTTCTTCAGTCCAACATTCAGC
ATGTGCTGGTCTATGAAAATCCTGCTCTTCAGGAGAAAGCGTTGGCTTGTATTCCGGTCCAAGAACTAAAAAGGAAATCACAAGAAAAGT
TATCGAGAGCTAGAAAATTGGATAAAGGTATCAATATAAGTGATGAGGATTTTCTTTTGCTGGAGCTTTTGCACTGGTTTAAGGAAGAAT
TTTTTCACTGGGTGAATAACGTTTTGTGCAGCAAATGTGGTGGACAGACTAGGTCTAGAGATAGATCATTACTGCCCAGTGATGATGAGC
TGAAGTGGGGTGCAAAGGAAGTGGAAGATCATTACTGTGATGCCTGCCAGTTCAGCAATCGATTCCCAAGATATAATAACCCTGAGAAAC
TTTTGGAAACAAGATGTGGACGGTGTGGCGAGTGGGCCAATTGTTTTACACTGTGCTGCCGAGCTGTAGGGTTTGAAGCTCGCTATGTTT
GGGATTACACAGACCATGTCTGGACAGAAGTCTATTCTCCTTCTCAGCAGCGGTGGCTGCACTGTGATGCATGTGAAGATGTCTGTGACA
AGCCACTCCTTTATGAAATAGGATGGGGCAAGAAGCTTTCCTATGTCATAGCATTTTCAAAAGATGAGGTAGTTGATGTCACTTGGCGAT
ATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATTACTTCGAGACACTATTAATGGGCTTAATAAGCAGA
GGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGTGGAGCTTGTTGAATTTATATCTCCCAAAACCCCTA
AACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGAAATGGGTCTACAGAGAAAAGAAACCTTGT
TTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATATTGTGAAAGATCGTTATGTTCGAGTTTCAAATAACA
ATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAGAAAAGTTGAAACAGACTGGCACATGATAACAGTCT
TCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGGAGATGGTGATGTCGCTTGGCAACACAC
CCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTATAAAATTCAGTGACCTTTGAGAACCTGAACATTA
TAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCATGCTTAGTTGGCAGTTACCACCCTGTGCTAGCATA

>63615_63615_2_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000307296_NGLY1_chr3_25792754_ENST00000396649_length(amino acids)=726AA_BP=332
MRWSSRKLPDPERRRSASLSASQSASPPAQYLSLLGPRKLSAVCLARTAAEALIMATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQ
AQYCRAAEELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFN
CAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKL
ANQAADYFGDAFKQCQYKDTLPKEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQVAADSAILEVLQSNIQHVLVYENPALQE
KALACIPVQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSRDRSLLPSDDELKWGAKEVEDHY
CDACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGFEARYVWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKK
LSYVIAFSKDEVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGS
VAWRVARGEMGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMITVFTPMLIFLVPLK

--------------------------------------------------------------
>63615_63615_3_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000307296_NGLY1_chr3_25792754_ENST00000417874_length(transcript)=2733nt_BP=1211nt
AGTACTTCTCCGGGGGGTTGTTCGAGTGGAGGAATACTCTTACGTGAAAGTGCTCAGTACACCACTGCGGCAGGAAGGAGGAAGGGAAGA
ATTCCAGATGGGGAGAAAGTAATATTTTGCAGCACAGTACAGGGTAAACTGGGTCCAGGTGGGCGTAGCCGCCGCGACACCTTCACGTGA
CCGCGGACAGCTTAAGGACCCCGCATCCAGTGCGCCTGCGCTGGAGCTCCCGGAAGTTGCCGGACCCGGAACGCAGGCGGAGCGCAAGTC
TGTCAGCCAGTCAGTCCGCCAGTCCGCCAGCCCAGTACCTCTCTCTCCTCGGCCCTCGTAAGCTGTCCGCGGTCTGTTTGGCCCGAACGG
CGGCGGAGGCGCTGATCATGGCGACATTCATCTCGGTGCAGCTGAAAAAGACCTCAGAGGTGGACCTGGCCAAGCCGCTGGTGAAGTTCA
TCCAGCAGACTTACCCAAGCGGCGGGGAAGAGCAGGCCCAGTACTGCCGCGCGGCGGAGGAGCTCAGCAAGCTGCGCCGCGCCGCAGTCG
GTCGTCCGCTGGACAAGCACGAGGGCGCGCTCGAGACGCTCCTGAGATATTATGATCAGATTTGTTCTATTGAACCCAAATTCCCATTTT
CTGAAAATCAGATCTGCTTGACATTTACCTGGAAGGATGCTTTCGATAAAGGTTCACTTTTTGGAGGCTCTGTAAAACTGGCTCTTGCAA
GCTTAGGATATGAAAAGAGCTGTGTGTTGTTCAATTGTGCAGCCTTAGCTAGCCAAATTGCAGCAGAACAGAACCTGGATAATGATGAAG
GATTGAAAATCGCTGCTAAACATTACCAGTTTGCTAGTGGTGCCTTTTTACATATTAAAGAGACGGTTTTATCTGCCTTAAGTCGAGAGC
CGACCGTGGACATATCTCCAGATACTGTTGGGACCCTCAGTCTTATTATGCTGGCACAGGCTCAAGAAGTATTTTTTTTAAAAGCCACAA
GAGATAAAATGAAAGATGCCATCATAGCTAAATTGGCTAATCAGGCTGCAGATTATTTTGGTGATGCTTTCAAACAGTGTCAATACAAAG
ATACTCTCCCCAAGGAGGTGTTCCCTGTCTTGGCTGCAAAGCACTGTATCATGCAGGCCAATGCTGAGTACCATCAGTCTATCCTGGCAA
AACAGCAGAAGAAATTTGGAGAAGAAATTGCAAGGTTACAGGTTGCTGCTGACTCAGCCATTCTAGAAGTTCTTCAGTCCAACATTCAGC
ATGTGCTGGTCTATGAAAATCCTGCTCTTCAGGAGAAAGCGTTGGCTTGTATTCCGGTCCAAGAACTAAAAAGGAAATCACAAGAAAAGT
TATCGAGAGCTAGAAAATTGGATAAAGGTATCAATATAAGTGATGAGGATTTTCTTTTGCTGGAGCTTTTGCACTGGTTTAAGGAAGAAT
TTTTTCACTGGGTGAATAACGTTTTGTGCAGCAAATGTGGTGGACAGACTAGGTCTAGAGATAGATCATTACTGCCCAGTGATGATGAGC
TGAAGTGGGGTGCAAAGGAAGTGGAAGATCATTACTGTGATGCCTGCCAGTTCAGCAATCGATTCCCAAGATATAATAACCCTGAGAAAC
TTTTGGAAACAAGATGTGGACGGTGTGGCGAGTGGGCCAATTGTTTTACACTGTGCTGCCGAGCTGTAGGGTTTGAAGCTCGCTATGTTT
GGGATTACACAGACCATGTCTGGACAGAAGTCTATTCTCCTTCTCAGCAGCGGTGGCTGCACTGTGATGCATGTGAAGATGTCTGTGACA
AGCCACTCCTTTATGAAATAGGATGGGGCAAGAAGCTTTCCTATGTCATAGCATTTTCAAAAGATGAGGTAGTTGATGTCACTTGGCGAT
ATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATTACTTCGAGACACTATTAATGGGCTTAATAAGCAGA
GGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGTGGAGCTTGTTGAATTTATATCTCCCAAAACCCCTA
AACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGAAATGGGTCTACAGAGAAAAGAAACCTTGT
TTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATATTGTGAAAGATCGTTATGTTCGAGTTTCAAATAACA
ATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAGAAAAGTTGAAACAGACTGGCACATGGTATATTTGG
CCCGAAAGGAAGGATCATCTTTTGCTTATATTTCCTGGAAGTTTGAGTGTGGGTCAGTTGGCCTAAAAGTAGATAGCATTTCTATTAGAA
CAAGTAGTCAAACTTTTCAGACTGGAACAGTAGAATGGAAATTGCGATCTGATACAGCACAAGTAGAACTGACAGGCGATAACAGTCTTC
ACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGGAGATGGTGATGTCGCTTGGCAACACACCC
AGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTATAAAATTCAGTGACCTTTGAGAACCTGAACATTATA

>63615_63615_3_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000307296_NGLY1_chr3_25792754_ENST00000417874_length(amino acids)=822AA_BP=332
MRWSSRKLPDPERRRSASLSASQSASPPAQYLSLLGPRKLSAVCLARTAAEALIMATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQ
AQYCRAAEELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFN
CAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKL
ANQAADYFGDAFKQCQYKDTLPKEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQVAADSAILEVLQSNIQHVLVYENPALQE
KALACIPVQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSRDRSLLPSDDELKWGAKEVEDHY
CDACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGFEARYVWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKK
LSYVIAFSKDEVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGS
VAWRVARGEMGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMVYLARKEGSSFAYIS
WKFECGSVGLKVDSISIRTSSQTFQTGTVEWKLRSDTAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEE

--------------------------------------------------------------
>63615_63615_4_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000307296_NGLY1_chr3_25792754_ENST00000428257_length(transcript)=3145nt_BP=1211nt
AGTACTTCTCCGGGGGGTTGTTCGAGTGGAGGAATACTCTTACGTGAAAGTGCTCAGTACACCACTGCGGCAGGAAGGAGGAAGGGAAGA
ATTCCAGATGGGGAGAAAGTAATATTTTGCAGCACAGTACAGGGTAAACTGGGTCCAGGTGGGCGTAGCCGCCGCGACACCTTCACGTGA
CCGCGGACAGCTTAAGGACCCCGCATCCAGTGCGCCTGCGCTGGAGCTCCCGGAAGTTGCCGGACCCGGAACGCAGGCGGAGCGCAAGTC
TGTCAGCCAGTCAGTCCGCCAGTCCGCCAGCCCAGTACCTCTCTCTCCTCGGCCCTCGTAAGCTGTCCGCGGTCTGTTTGGCCCGAACGG
CGGCGGAGGCGCTGATCATGGCGACATTCATCTCGGTGCAGCTGAAAAAGACCTCAGAGGTGGACCTGGCCAAGCCGCTGGTGAAGTTCA
TCCAGCAGACTTACCCAAGCGGCGGGGAAGAGCAGGCCCAGTACTGCCGCGCGGCGGAGGAGCTCAGCAAGCTGCGCCGCGCCGCAGTCG
GTCGTCCGCTGGACAAGCACGAGGGCGCGCTCGAGACGCTCCTGAGATATTATGATCAGATTTGTTCTATTGAACCCAAATTCCCATTTT
CTGAAAATCAGATCTGCTTGACATTTACCTGGAAGGATGCTTTCGATAAAGGTTCACTTTTTGGAGGCTCTGTAAAACTGGCTCTTGCAA
GCTTAGGATATGAAAAGAGCTGTGTGTTGTTCAATTGTGCAGCCTTAGCTAGCCAAATTGCAGCAGAACAGAACCTGGATAATGATGAAG
GATTGAAAATCGCTGCTAAACATTACCAGTTTGCTAGTGGTGCCTTTTTACATATTAAAGAGACGGTTTTATCTGCCTTAAGTCGAGAGC
CGACCGTGGACATATCTCCAGATACTGTTGGGACCCTCAGTCTTATTATGCTGGCACAGGCTCAAGAAGTATTTTTTTTAAAAGCCACAA
GAGATAAAATGAAAGATGCCATCATAGCTAAATTGGCTAATCAGGCTGCAGATTATTTTGGTGATGCTTTCAAACAGTGTCAATACAAAG
ATACTCTCCCCAAGGAGGTGTTCCCTGTCTTGGCTGCAAAGCACTGTATCATGCAGGCCAATGCTGAGTACCATCAGTCTATCCTGGCAA
AACAGCAGAAGAAATTTGGAGAAGAAATTGCAAGGTTACAGGTTGCTGCTGACTCAGCCATTCTAGAAGTTCTTCAGTCCAACATTCAGC
ATGTGCTGGTCTATGAAAATCCTGCTCTTCAGGAGAAAGCGTTGGCTTGTATTCCGGTCCAAGAACTAAAAAGGAAATCACAAGAAAAGT
TATCGAGAGCTAGAAAATTGGATAAAGGTATCAATATAAGTGATGAGGATTTTCTTTTGCTGGAGCTTTTGCACTGGTTTAAGGAAGAAT
TTTTTCACTGGGTGAATAACGTTTTGTGCAGCAAATGTGGTGGACAGACTAGGTCTAGAGATAGATCATTACTGCCCAGTGATGATGAGC
TGAAGTGGGGTGCAAAGGAAGTGGAAGATCATTACTGTGATGCCTGCCAGTTCAGCAATCGATTCCCAAGATATAATAACCCTGAGAAAC
TTTTGGAAACAAGATGTGGACGGTGTGGCGAGTGGGCCAATTGTTTTACACTGTGCTGCCGAGCTGTAGGGTTTGAAGCTCGCTATGTTT
GGGATTACACAGAGTTACAGCGCACATTAAGCCTAAAACTGACCACGTTAAAGGAGATTGGAAAAACATTTTTAAGGATTTCAAAGAGAC
AGAAATTAATACAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCAT
TACTTCGAGACACTATTAATGGGCTTAATAAGCAGAGGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTG
TGGAGCTTGTTGAATTTATATCTCCCAAAACCCCTAAACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCC
GAGGTGAAATGGGTCTACAGAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATA
TTGTGAAAGATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCA
GAAAAGTTGAAACAGACTGGCACATGGTATATTTGGCCCGAAAGGAAGGATCATCTTTTGCTTATATTTCCTGGAAGTTTGAGTGTGGGT
CAGTTGGCCTAAAAGTAGATAGCATTTCTATTAGAACAAGTAGTCAAACTTTTCAGACTGGAACAGTAGAATGGAAATTGCGATCTGATA
CAGCACAAGTAGAACTGACAGGCGATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAA
GCAGAGGAGATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTA
TAAAATTCAGTGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCAT
GCTTAGTTGGCAGTTACCACCCTGTGCTAGCATATTTCTTTTGCTAGCTATCCATCATGTAACCCTCATGAAAATTATCTTTATACGTGG
ACTATAATAAAATATTGAATTAAAACCTTTCTTCCATATGTGACTATAATTTGGAGTAAAGTCTTGTTGACTCAATATGGGATTTTAATC
TAAAACTGTAAGTATGGTTTTAAAAGTTAAATAATGATATTCATGATTAAATGCTATTCATGATTATGATAAAATCTTGGGCTTATGATA
GTAATTTGACATTTTCTGATCAGCCATTCATTTCTTCAGAAGTGGTTAAATTAGAGTCTCCTAATATTTTTAATTAATGTGAAAGTACAG

>63615_63615_4_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000307296_NGLY1_chr3_25792754_ENST00000428257_length(amino acids)=804AA_BP=332
MRWSSRKLPDPERRRSASLSASQSASPPAQYLSLLGPRKLSAVCLARTAAEALIMATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQ
AQYCRAAEELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFN
CAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKL
ANQAADYFGDAFKQCQYKDTLPKEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQVAADSAILEVLQSNIQHVLVYENPALQE
KALACIPVQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSRDRSLLPSDDELKWGAKEVEDHY
CDACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGFEARYVWDYTELQRTLSLKLTTLKEIGKTFLRISKRQKLIQVVDVTWR
YSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVAWRVARGEMGLQRKETL
FIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMVYLARKEGSSFAYISWKFECGSVGLKVDSISIR

--------------------------------------------------------------
>63615_63615_5_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000457054_NGLY1_chr3_25792754_ENST00000280700_length(transcript)=2824nt_BP=1004nt
GGAGCTCCCGGAAGTTGCCGGACCCGGAACGCAGGCGGAGCGCAAGTCTGTCAGCCAGTCAGTCCGCCAGTCCGCCAGCCCAGTACCTCT
CTCTCCTCGGCCCTCGTAAGCTGTCCGCGGTCTGTTTGGCCCGAACGGCGGCGGAGGCGCTGATCATGGCGACATTCATCTCGGTGCAGC
TGAAAAAGACCTCAGAGGTGGACCTGGCCAAGCCGCTGGTGAAGTTCATCCAGCAGACTTACCCAAGCGGCGGGGAAGAGCAGGCCCAGT
ACTGCCGCGCGGCGGAGGAGCTCAGCAAGCTGCGCCGCGCCGCAGTCGGTCGTCCGCTGGACAAGCACGAGGGCGCGCTCGAGACGCTCC
TGAGATATTATGATCAGATTTGTTCTATTGAACCCAAATTCCCATTTTCTGAAAATCAGATCTGCTTGACATTTACCTGGAAGGATGCTT
TCGATAAAGGTTCACTTTTTGGAGGCTCTGTAAAACTGGCTCTTGCAAGCTTAGGATATGAAAAGAGCTGTGTGTTGTTCAATTGTGCAG
CCTTAGCTAGCCAAATTGCAGCAGAACAGAACCTGGATAATGATGAAGGATTGAAAATCGCTGCTAAACATTACCAGTTTGCTAGTGGTG
CCTTTTTACATATTAAAGAGACGGTTTTATCTGCCTTAAGTCGAGAGCCGACCGTGGACATATCTCCAGATACTGTTGGGACCCTCAGTC
TTATTATGCTGGCACAGGCTCAAGAAGTATTTTTTTTAAAAGCCACAAGAGATAAAATGAAAGATGCCATCATAGCTAAATTGGCTAATC
AGGCTGCAGATTATTTTGGTGATGCTTTCAAACAGTGTCAATACAAAGATACTCTCCCCAAGTATTTTTATTTCCAGGAGGTGTTCCCTG
TCTTGGCTGCAAAGCACTGTATCATGCAGGCCAATGCTGAGTACCATCAGTCTATCCTGGCAAAACAGCAGAAGAAATTTGGAGAAGAAA
TTGCAAGGTTACAGGTTGCTGCTGACTCAGCCATTCTAGAAGTTCTTCAGTCCAACATTCAGCATGTGCTGGTCTATGAAAATCCTGCTC
TTCAGGAGAAAGCGTTGGCTTGTATTCCGGTCCAAGAACTAAAAAGGAAATCACAAGAAAAGTTATCGAGAGCTAGAAAATTGGATAAAG
GTATCAATATAAGTGATGAGGATTTTCTTTTGCTGGAGCTTTTGCACTGGTTTAAGGAAGAATTTTTTCACTGGGTGAATAACGTTTTGT
GCAGCAAATGTGGTGGACAGACTAGGTCTAGAGATAGATCATTACTGCCCAGTGATGATGAGCTGAAGTGGGGTGCAAAGGAAGTGGAAG
ATCATTACTGTGATGCCTGCCAGTTCAGCAATCGATTCCCAAGATATAATAACCCTGAGAAACTTTTGGAAACAAGATGTGGACGGTGTG
GCGAGTGGGCCAATTGTTTTACACTGTGCTGCCGAGCTGTAGGGTTTGAAGCTCGCTATGTTTGGGATTACACAGACCATGTCTGGACAG
AAGTCTATTCTCCTTCTCAGCAGCGGTGGCTGCACTGTGATGCATGTGAAGATGTCTGTGACAAGCCACTCCTTTATGAAATAGGATGGG
GCAAGAAGCTTTCCTATGTCATAGCATTTTCAAAAGATGAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTG
CCAGAAGAACTAAGGTTAAAGAAGCATTACTTCGAGACACTATTAATGGGCTTAATAAGCAGAGGCAACTGTTTTTGTCAGAAAACAGAA
GGAAAGAACTTCTCCAGAGGATAATTGTGGAGCTTGTTGAATTTATATCTCCCAAAACCCCTAAACCTGGAGAACTTGGGGGAAGAATAT
CTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGAAATGGGTCTACAGAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTT
CTAAACAGCTCCACCTTTGTTACAATATTGTGAAAGATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATG
GCGTGTGGAAAATGGAATCTATATTCAGAAAAGTTGAAACAGACTGGCACATGGTATATTTGGCCCGAAAGGAAGGATCATCTTTTGCTT
ATATTTCCTGGAAGTTTGAGTGTGGGTCAGTTGGCCTAAAAGTAGATAGCATTTCTATTAGAACAAGTAGTCAAACTTTTCAGACTGGAA
CAGTAGAATGGAAATTGCGATCTGATACAGCACAAGTAGAACTGACAGGCGATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCA
CTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGGAGATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACC
ATGAAGAAAATTGTTTGGAGATAATTATAAAATTCAGTGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTA
CTGAAGTAGTCTGTTGGTTCAGTGCATGCTTAGTTGGCAGTTACCACCCTGTGCTAGCATATTTCTTTTGCTAGCTATCCATCATGTAAC
CCTCATGAAAATTATCTTTATACGTGGACTATAATAAAATATTGAATTAAAACCTTTCTTCCATATGTGACTATAATTTGGAGTAAAGTC
TTGTTGACTCAATATGGGATTTTAATCTAAAACTGTAAGTATGGTTTTAAAAGTTAAATAATGATATTCATGATTAAATGCTATTCATGA

>63615_63615_5_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000457054_NGLY1_chr3_25792754_ENST00000280700_length(amino acids)=820AA_BP=330
MPDPERRRSASLSASQSASPPAQYLSLLGPRKLSAVCLARTAAEALIMATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAA
EELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQ
IAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADY
FGDAFKQCQYKDTLPKYFYFQEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQVAADSAILEVLQSNIQHVLVYENPALQEKA
LACIPVQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSRDRSLLPSDDELKWGAKEVEDHYCD
ACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGFEARYVWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKKLS
YVIAFSKDEVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVA
WRVARGEMGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMVYLARKEGSSFAYISWK
FECGSVGLKVDSISIRTSSQTFQTGTVEWKLRSDTAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEENC

--------------------------------------------------------------
>63615_63615_6_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000457054_NGLY1_chr3_25792754_ENST00000396649_length(transcript)=2488nt_BP=1004nt
GGAGCTCCCGGAAGTTGCCGGACCCGGAACGCAGGCGGAGCGCAAGTCTGTCAGCCAGTCAGTCCGCCAGTCCGCCAGCCCAGTACCTCT
CTCTCCTCGGCCCTCGTAAGCTGTCCGCGGTCTGTTTGGCCCGAACGGCGGCGGAGGCGCTGATCATGGCGACATTCATCTCGGTGCAGC
TGAAAAAGACCTCAGAGGTGGACCTGGCCAAGCCGCTGGTGAAGTTCATCCAGCAGACTTACCCAAGCGGCGGGGAAGAGCAGGCCCAGT
ACTGCCGCGCGGCGGAGGAGCTCAGCAAGCTGCGCCGCGCCGCAGTCGGTCGTCCGCTGGACAAGCACGAGGGCGCGCTCGAGACGCTCC
TGAGATATTATGATCAGATTTGTTCTATTGAACCCAAATTCCCATTTTCTGAAAATCAGATCTGCTTGACATTTACCTGGAAGGATGCTT
TCGATAAAGGTTCACTTTTTGGAGGCTCTGTAAAACTGGCTCTTGCAAGCTTAGGATATGAAAAGAGCTGTGTGTTGTTCAATTGTGCAG
CCTTAGCTAGCCAAATTGCAGCAGAACAGAACCTGGATAATGATGAAGGATTGAAAATCGCTGCTAAACATTACCAGTTTGCTAGTGGTG
CCTTTTTACATATTAAAGAGACGGTTTTATCTGCCTTAAGTCGAGAGCCGACCGTGGACATATCTCCAGATACTGTTGGGACCCTCAGTC
TTATTATGCTGGCACAGGCTCAAGAAGTATTTTTTTTAAAAGCCACAAGAGATAAAATGAAAGATGCCATCATAGCTAAATTGGCTAATC
AGGCTGCAGATTATTTTGGTGATGCTTTCAAACAGTGTCAATACAAAGATACTCTCCCCAAGTATTTTTATTTCCAGGAGGTGTTCCCTG
TCTTGGCTGCAAAGCACTGTATCATGCAGGCCAATGCTGAGTACCATCAGTCTATCCTGGCAAAACAGCAGAAGAAATTTGGAGAAGAAA
TTGCAAGGTTACAGGTTGCTGCTGACTCAGCCATTCTAGAAGTTCTTCAGTCCAACATTCAGCATGTGCTGGTCTATGAAAATCCTGCTC
TTCAGGAGAAAGCGTTGGCTTGTATTCCGGTCCAAGAACTAAAAAGGAAATCACAAGAAAAGTTATCGAGAGCTAGAAAATTGGATAAAG
GTATCAATATAAGTGATGAGGATTTTCTTTTGCTGGAGCTTTTGCACTGGTTTAAGGAAGAATTTTTTCACTGGGTGAATAACGTTTTGT
GCAGCAAATGTGGTGGACAGACTAGGTCTAGAGATAGATCATTACTGCCCAGTGATGATGAGCTGAAGTGGGGTGCAAAGGAAGTGGAAG
ATCATTACTGTGATGCCTGCCAGTTCAGCAATCGATTCCCAAGATATAATAACCCTGAGAAACTTTTGGAAACAAGATGTGGACGGTGTG
GCGAGTGGGCCAATTGTTTTACACTGTGCTGCCGAGCTGTAGGGTTTGAAGCTCGCTATGTTTGGGATTACACAGACCATGTCTGGACAG
AAGTCTATTCTCCTTCTCAGCAGCGGTGGCTGCACTGTGATGCATGTGAAGATGTCTGTGACAAGCCACTCCTTTATGAAATAGGATGGG
GCAAGAAGCTTTCCTATGTCATAGCATTTTCAAAAGATGAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTG
CCAGAAGAACTAAGGTTAAAGAAGCATTACTTCGAGACACTATTAATGGGCTTAATAAGCAGAGGCAACTGTTTTTGTCAGAAAACAGAA
GGAAAGAACTTCTCCAGAGGATAATTGTGGAGCTTGTTGAATTTATATCTCCCAAAACCCCTAAACCTGGAGAACTTGGGGGAAGAATAT
CTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGAAATGGGTCTACAGAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTT
CTAAACAGCTCCACCTTTGTTACAATATTGTGAAAGATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATG
GCGTGTGGAAAATGGAATCTATATTCAGAAAAGTTGAAACAGACTGGCACATGATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGC
CACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGGAGATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGA
CCATGAAGAAAATTGTTTGGAGATAATTATAAAATTCAGTGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACT
TACTGAAGTAGTCTGTTGGTTCAGTGCATGCTTAGTTGGCAGTTACCACCCTGTGCTAGCATATTTCTTTTGCTAGCTATCCATCATGTA

>63615_63615_6_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000457054_NGLY1_chr3_25792754_ENST00000396649_length(amino acids)=724AA_BP=330
MPDPERRRSASLSASQSASPPAQYLSLLGPRKLSAVCLARTAAEALIMATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAA
EELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQ
IAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADY
FGDAFKQCQYKDTLPKYFYFQEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQVAADSAILEVLQSNIQHVLVYENPALQEKA
LACIPVQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSRDRSLLPSDDELKWGAKEVEDHYCD
ACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGFEARYVWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKKLS
YVIAFSKDEVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVA
WRVARGEMGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMITVFTPMLIFLVPLKLF

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>63615_63615_7_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000457054_NGLY1_chr3_25792754_ENST00000417874_length(transcript)=2526nt_BP=1004nt
GGAGCTCCCGGAAGTTGCCGGACCCGGAACGCAGGCGGAGCGCAAGTCTGTCAGCCAGTCAGTCCGCCAGTCCGCCAGCCCAGTACCTCT
CTCTCCTCGGCCCTCGTAAGCTGTCCGCGGTCTGTTTGGCCCGAACGGCGGCGGAGGCGCTGATCATGGCGACATTCATCTCGGTGCAGC
TGAAAAAGACCTCAGAGGTGGACCTGGCCAAGCCGCTGGTGAAGTTCATCCAGCAGACTTACCCAAGCGGCGGGGAAGAGCAGGCCCAGT
ACTGCCGCGCGGCGGAGGAGCTCAGCAAGCTGCGCCGCGCCGCAGTCGGTCGTCCGCTGGACAAGCACGAGGGCGCGCTCGAGACGCTCC
TGAGATATTATGATCAGATTTGTTCTATTGAACCCAAATTCCCATTTTCTGAAAATCAGATCTGCTTGACATTTACCTGGAAGGATGCTT
TCGATAAAGGTTCACTTTTTGGAGGCTCTGTAAAACTGGCTCTTGCAAGCTTAGGATATGAAAAGAGCTGTGTGTTGTTCAATTGTGCAG
CCTTAGCTAGCCAAATTGCAGCAGAACAGAACCTGGATAATGATGAAGGATTGAAAATCGCTGCTAAACATTACCAGTTTGCTAGTGGTG
CCTTTTTACATATTAAAGAGACGGTTTTATCTGCCTTAAGTCGAGAGCCGACCGTGGACATATCTCCAGATACTGTTGGGACCCTCAGTC
TTATTATGCTGGCACAGGCTCAAGAAGTATTTTTTTTAAAAGCCACAAGAGATAAAATGAAAGATGCCATCATAGCTAAATTGGCTAATC
AGGCTGCAGATTATTTTGGTGATGCTTTCAAACAGTGTCAATACAAAGATACTCTCCCCAAGTATTTTTATTTCCAGGAGGTGTTCCCTG
TCTTGGCTGCAAAGCACTGTATCATGCAGGCCAATGCTGAGTACCATCAGTCTATCCTGGCAAAACAGCAGAAGAAATTTGGAGAAGAAA
TTGCAAGGTTACAGGTTGCTGCTGACTCAGCCATTCTAGAAGTTCTTCAGTCCAACATTCAGCATGTGCTGGTCTATGAAAATCCTGCTC
TTCAGGAGAAAGCGTTGGCTTGTATTCCGGTCCAAGAACTAAAAAGGAAATCACAAGAAAAGTTATCGAGAGCTAGAAAATTGGATAAAG
GTATCAATATAAGTGATGAGGATTTTCTTTTGCTGGAGCTTTTGCACTGGTTTAAGGAAGAATTTTTTCACTGGGTGAATAACGTTTTGT
GCAGCAAATGTGGTGGACAGACTAGGTCTAGAGATAGATCATTACTGCCCAGTGATGATGAGCTGAAGTGGGGTGCAAAGGAAGTGGAAG
ATCATTACTGTGATGCCTGCCAGTTCAGCAATCGATTCCCAAGATATAATAACCCTGAGAAACTTTTGGAAACAAGATGTGGACGGTGTG
GCGAGTGGGCCAATTGTTTTACACTGTGCTGCCGAGCTGTAGGGTTTGAAGCTCGCTATGTTTGGGATTACACAGACCATGTCTGGACAG
AAGTCTATTCTCCTTCTCAGCAGCGGTGGCTGCACTGTGATGCATGTGAAGATGTCTGTGACAAGCCACTCCTTTATGAAATAGGATGGG
GCAAGAAGCTTTCCTATGTCATAGCATTTTCAAAAGATGAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTG
CCAGAAGAACTAAGGTTAAAGAAGCATTACTTCGAGACACTATTAATGGGCTTAATAAGCAGAGGCAACTGTTTTTGTCAGAAAACAGAA
GGAAAGAACTTCTCCAGAGGATAATTGTGGAGCTTGTTGAATTTATATCTCCCAAAACCCCTAAACCTGGAGAACTTGGGGGAAGAATAT
CTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGAAATGGGTCTACAGAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTT
CTAAACAGCTCCACCTTTGTTACAATATTGTGAAAGATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATG
GCGTGTGGAAAATGGAATCTATATTCAGAAAAGTTGAAACAGACTGGCACATGGTATATTTGGCCCGAAAGGAAGGATCATCTTTTGCTT
ATATTTCCTGGAAGTTTGAGTGTGGGTCAGTTGGCCTAAAAGTAGATAGCATTTCTATTAGAACAAGTAGTCAAACTTTTCAGACTGGAA
CAGTAGAATGGAAATTGCGATCTGATACAGCACAAGTAGAACTGACAGGCGATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCA
CTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGGAGATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACC
ATGAAGAAAATTGTTTGGAGATAATTATAAAATTCAGTGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTA

>63615_63615_7_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000457054_NGLY1_chr3_25792754_ENST00000417874_length(amino acids)=820AA_BP=330
MPDPERRRSASLSASQSASPPAQYLSLLGPRKLSAVCLARTAAEALIMATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAA
EELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQ
IAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADY
FGDAFKQCQYKDTLPKYFYFQEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQVAADSAILEVLQSNIQHVLVYENPALQEKA
LACIPVQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSRDRSLLPSDDELKWGAKEVEDHYCD
ACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGFEARYVWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKKLS
YVIAFSKDEVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVA
WRVARGEMGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMVYLARKEGSSFAYISWK
FECGSVGLKVDSISIRTSSQTFQTGTVEWKLRSDTAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEENC

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>63615_63615_8_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000457054_NGLY1_chr3_25792754_ENST00000428257_length(transcript)=2938nt_BP=1004nt
GGAGCTCCCGGAAGTTGCCGGACCCGGAACGCAGGCGGAGCGCAAGTCTGTCAGCCAGTCAGTCCGCCAGTCCGCCAGCCCAGTACCTCT
CTCTCCTCGGCCCTCGTAAGCTGTCCGCGGTCTGTTTGGCCCGAACGGCGGCGGAGGCGCTGATCATGGCGACATTCATCTCGGTGCAGC
TGAAAAAGACCTCAGAGGTGGACCTGGCCAAGCCGCTGGTGAAGTTCATCCAGCAGACTTACCCAAGCGGCGGGGAAGAGCAGGCCCAGT
ACTGCCGCGCGGCGGAGGAGCTCAGCAAGCTGCGCCGCGCCGCAGTCGGTCGTCCGCTGGACAAGCACGAGGGCGCGCTCGAGACGCTCC
TGAGATATTATGATCAGATTTGTTCTATTGAACCCAAATTCCCATTTTCTGAAAATCAGATCTGCTTGACATTTACCTGGAAGGATGCTT
TCGATAAAGGTTCACTTTTTGGAGGCTCTGTAAAACTGGCTCTTGCAAGCTTAGGATATGAAAAGAGCTGTGTGTTGTTCAATTGTGCAG
CCTTAGCTAGCCAAATTGCAGCAGAACAGAACCTGGATAATGATGAAGGATTGAAAATCGCTGCTAAACATTACCAGTTTGCTAGTGGTG
CCTTTTTACATATTAAAGAGACGGTTTTATCTGCCTTAAGTCGAGAGCCGACCGTGGACATATCTCCAGATACTGTTGGGACCCTCAGTC
TTATTATGCTGGCACAGGCTCAAGAAGTATTTTTTTTAAAAGCCACAAGAGATAAAATGAAAGATGCCATCATAGCTAAATTGGCTAATC
AGGCTGCAGATTATTTTGGTGATGCTTTCAAACAGTGTCAATACAAAGATACTCTCCCCAAGTATTTTTATTTCCAGGAGGTGTTCCCTG
TCTTGGCTGCAAAGCACTGTATCATGCAGGCCAATGCTGAGTACCATCAGTCTATCCTGGCAAAACAGCAGAAGAAATTTGGAGAAGAAA
TTGCAAGGTTACAGGTTGCTGCTGACTCAGCCATTCTAGAAGTTCTTCAGTCCAACATTCAGCATGTGCTGGTCTATGAAAATCCTGCTC
TTCAGGAGAAAGCGTTGGCTTGTATTCCGGTCCAAGAACTAAAAAGGAAATCACAAGAAAAGTTATCGAGAGCTAGAAAATTGGATAAAG
GTATCAATATAAGTGATGAGGATTTTCTTTTGCTGGAGCTTTTGCACTGGTTTAAGGAAGAATTTTTTCACTGGGTGAATAACGTTTTGT
GCAGCAAATGTGGTGGACAGACTAGGTCTAGAGATAGATCATTACTGCCCAGTGATGATGAGCTGAAGTGGGGTGCAAAGGAAGTGGAAG
ATCATTACTGTGATGCCTGCCAGTTCAGCAATCGATTCCCAAGATATAATAACCCTGAGAAACTTTTGGAAACAAGATGTGGACGGTGTG
GCGAGTGGGCCAATTGTTTTACACTGTGCTGCCGAGCTGTAGGGTTTGAAGCTCGCTATGTTTGGGATTACACAGAGTTACAGCGCACAT
TAAGCCTAAAACTGACCACGTTAAAGGAGATTGGAAAAACATTTTTAAGGATTTCAAAGAGACAGAAATTAATACAGGTAGTTGATGTCA
CTTGGCGATATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATTACTTCGAGACACTATTAATGGGCTTA
ATAAGCAGAGGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGTGGAGCTTGTTGAATTTATATCTCCCA
AAACCCCTAAACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGAAATGGGTCTACAGAGAAAAG
AAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATATTGTGAAAGATCGTTATGTTCGAGTTT
CAAATAACAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAGAAAAGTTGAAACAGACTGGCACATGG
TATATTTGGCCCGAAAGGAAGGATCATCTTTTGCTTATATTTCCTGGAAGTTTGAGTGTGGGTCAGTTGGCCTAAAAGTAGATAGCATTT
CTATTAGAACAAGTAGTCAAACTTTTCAGACTGGAACAGTAGAATGGAAATTGCGATCTGATACAGCACAAGTAGAACTGACAGGCGATA
ACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGGAGATGGTGATGTCGCTTGGC
AACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTATAAAATTCAGTGACCTTTGAGAACCTG
AACATTATAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCATGCTTAGTTGGCAGTTACCACCCTGTGC
TAGCATATTTCTTTTGCTAGCTATCCATCATGTAACCCTCATGAAAATTATCTTTATACGTGGACTATAATAAAATATTGAATTAAAACC
TTTCTTCCATATGTGACTATAATTTGGAGTAAAGTCTTGTTGACTCAATATGGGATTTTAATCTAAAACTGTAAGTATGGTTTTAAAAGT
TAAATAATGATATTCATGATTAAATGCTATTCATGATTATGATAAAATCTTGGGCTTATGATAGTAATTTGACATTTTCTGATCAGCCAT
TCATTTCTTCAGAAGTGGTTAAATTAGAGTCTCCTAATATTTTTAATTAATGTGAAAGTACAGTAGCTCATAAATTATATAATGCATGAA

>63615_63615_8_PDCD6IP-NGLY1_PDCD6IP_chr3_33870461_ENST00000457054_NGLY1_chr3_25792754_ENST00000428257_length(amino acids)=802AA_BP=330
MPDPERRRSASLSASQSASPPAQYLSLLGPRKLSAVCLARTAAEALIMATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAA
EELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQ
IAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADY
FGDAFKQCQYKDTLPKYFYFQEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQVAADSAILEVLQSNIQHVLVYENPALQEKA
LACIPVQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSRDRSLLPSDDELKWGAKEVEDHYCD
ACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGFEARYVWDYTELQRTLSLKLTTLKEIGKTFLRISKRQKLIQVVDVTWRYS
CKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVAWRVARGEMGLQRKETLFI
PCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMVYLARKEGSSFAYISWKFECGSVGLKVDSISIRTS

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Fusion Gene PPI Analysis for PDCD6IP-NGLY1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000307296+718801_806278.0869.0CEP55
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000457054+718801_806283.0874.0CEP55
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000307296+718176_503278.0869.0CHMP4A%2C CHMP4B and CHMP4C
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000457054+718176_503283.0874.0CHMP4A%2C CHMP4B and CHMP4C
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000307296+718176_868278.0869.0EIAV p9
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000457054+718176_868283.0874.0EIAV p9
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000307296+718418_868278.0869.0SDCBP
HgenePDCD6IPchr3:33870461chr3:25792754ENST00000457054+718418_868283.0874.0SDCBP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDCD6IP-NGLY1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDCD6IP-NGLY1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource